Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y9 7615
2R:R:E13 8.954516
3R:R:N24 7.76409
4R:R:N34 7.905426
5R:R:L37 7.8025428
6R:R:N42 7.385428
7R:R:F44 5.285407
8R:R:V55 5.1775406
9R:R:I60 5.05833616
10R:R:F62 7.085445
11R:R:F70 4.405407
12R:R:C74 4.1375453
13R:R:L78 4.835456
14R:R:F83 7.515445
15R:R:L85 5.29514
16R:R:Q89 7.106515
17R:R:I92 4.97407
18R:R:D101 8.815439
19R:R:R102 7.0325439
20R:R:Y103 7.475488
21R:R:I104 3.53435
22R:R:Y112 8.038537
23R:R:V116 6.086537
24R:R:I135 5.0125414
25R:R:W143 8.8625415
26R:R:N144 4.218554
27R:R:C146 5.376551
28R:R:F168 12.4125414
29R:R:P173 6.645414
30R:R:M174 5.485414
31R:R:Y176 7.78857716
32R:R:M177 4.90667616
33R:R:F182 8.7825415
34R:R:F183 3.816514
35R:R:Y197 4.00833609
36R:R:I200 3.385489
37R:R:F242 8.2025409
38R:R:W246 11.5875418
39R:R:L247 1.7725406
40R:R:H250 11.16406
41R:R:F257 8.2875413
42R:R:F258 5.8125416
43R:R:H278 8.0775416
44R:R:Y288 5.434529
45R:R:E294 6.5725426
46R:R:F295 7.49628
47R:R:H306 5.0975464
48L:L:?1 9.182141410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E13 R:R:Y9 38.966514.59YesYes165
2L:L:?1 R:R:Y9 39.09114.42YesYes105
3R:R:E13 R:R:I60 38.55445.47YesYes166
4R:R:I60 R:R:V55 1003.07YesYes066
5R:R:S281 R:R:V55 90.83638.08NoYes096
6R:R:F83 R:R:L87 12.87710.96YesNo057
7R:R:L87 R:R:V55 14.95654.47NoYes076
8R:R:N24 R:R:P285 43.106311.4YesNo099
9R:R:D52 R:R:N24 86.179112.12NoYes099
10R:R:D52 R:R:S281 88.011810.31NoNo099
11R:R:A49 R:R:N24 41.23284.69NoYes099
12R:R:F295 R:R:F299 23.15716.43YesNo086
13R:R:F295 R:R:Y288 57.9675.16YesYes289
14R:R:V27 R:R:Y288 78.10793.79NoYes099
15R:R:A49 R:R:V27 39.71873.39NoNo099
16R:R:P285 R:R:V27 40.07813.53NoNo099
17R:R:F299 R:R:L26 19.553913.4NoNo066
18R:R:I302 R:R:L26 12.58954.28NoNo066
19R:R:F295 R:R:L37 21.817912.18YesYes288
20R:R:E294 R:R:L37 12.79325.3YesYes268
21L:L:?1 R:R:W246 16.199911.04YesYes108
22R:R:F242 R:R:W246 43.645312.03YesYes098
23R:R:F242 R:R:L95 37.83816.09YesNo098
24R:R:L95 R:R:V239 37.21522.98NoNo088
25R:R:M193 R:R:V239 22.00714.56NoNo088
26R:R:L96 R:R:M193 21.26935.65NoNo078
27R:R:I100 R:R:L96 19.77914.28NoNo067
28R:R:I100 R:R:I104 19.02692.94NoYes065
29R:R:F242 R:R:I92 17.69485.02YesYes097
30R:R:I92 R:R:Q89 15.42376.86YesYes075
31R:R:Q89 R:R:S132 16.28855.78YesNo057
32R:R:S132 R:R:S90 15.30634.89NoNo076
33R:R:S90 R:R:W129 14.319318.53NoNo069
34R:R:S47 R:R:W129 12.33086.18NoNo099
35R:R:I125 R:R:S47 10.32326.19NoNo089
36L:L:?1 R:R:H250 22.67086.23YesYes006
37R:R:C166 R:R:F70 15.37826.98NoYes097
38R:R:C166 R:R:C77 16.62877.28NoNo099
39R:R:C77 R:R:V171 17.87215.12NoNo094
40R:R:C146 R:R:V171 19.11313.42YesNo014
41R:R:C146 R:R:L78 21.28364.76YesYes516
42R:R:C82 R:R:L78 28.5693.17NoYes056
43R:R:C82 R:R:L85 27.25383.17NoYes054
44L:L:?1 R:R:L85 29.9256.71YesYes104
45R:R:F70 R:R:T68 11.59773.89YesNo075
46R:R:G69 R:R:T68 10.3281.82NoNo045
47L:L:?1 R:R:M177 20.50266.85YesYes106
48R:R:F180 R:R:Y176 13.79948.25NoYes146
49R:R:V239 R:R:Y197 17.42892.52NoYes089
50R:R:I200 R:R:Y197 12.92492.42YesYes099
51R:R:E169 R:R:M174 17.83864.06NoYes134
52R:R:M174 R:R:M177 15.81664.33YesYes146
53R:R:M174 R:R:N253 13.31079.82YesNo145
54L:L:?1 R:R:N253 14.23549.62YesNo105
55R:R:E169 R:R:H264 14.00069.85NoNo132
56R:R:F257 R:R:M174 11.69353.73YesYes134
57R:R:F182 R:R:H250 20.842824.89YesYes056
58R:R:I238 R:R:Y288 11.01794.84NoYes289
59R:R:H278 R:R:S277 28.28634.18YesNo067
60R:R:S277 R:R:W246 28.444512.36NoYes078
61L:L:?1 R:R:I274 36.302416.91YesNo104
62R:R:H264 R:R:M270 12.13675.25NoNo024
63R:R:I252 R:R:M270 10.22745.83NoNo054
64R:R:H278 R:R:I274 36.40783.98YesNo164
65R:R:H278 R:R:I60 63.874810.61YesYes166
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I10 R:R:Y9 3.63 0 No Yes 6 5 2 1
R:R:E13 R:R:Y9 14.59 1 Yes Yes 6 5 2 1
R:R:I64 R:R:Y9 3.63 1 No Yes 6 5 2 1
R:R:S67 R:R:Y9 3.82 1 No Yes 3 5 1 1
R:R:Y271 R:R:Y9 11.91 1 No Yes 3 5 1 1
L:L:?1 R:R:Y9 4.42 1 Yes Yes 0 5 0 1
R:R:E13 R:R:I64 5.47 1 Yes No 6 6 2 2
R:R:E13 R:R:H278 13.54 1 Yes Yes 6 6 2 2
L:L:?1 R:R:A63 3.39 1 Yes No 0 5 0 1
L:L:?1 R:R:I66 5.38 1 Yes No 0 4 0 1
L:L:?1 R:R:S67 5.66 1 Yes No 0 3 0 1
R:R:C82 R:R:L85 3.17 0 No Yes 5 4 2 1
R:R:L85 R:R:Y176 8.21 1 Yes Yes 4 6 1 2
R:R:L85 R:R:M177 4.24 1 Yes Yes 4 6 1 1
R:R:L85 R:R:N181 4.12 1 Yes No 4 5 1 2
L:L:?1 R:R:L85 6.71 1 Yes Yes 0 4 0 1
R:R:T88 R:R:W246 10.92 1 No Yes 6 8 1 1
L:L:?1 R:R:T88 4.76 1 Yes No 0 6 0 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 26.24 1 Yes Yes 0 4 0 1
R:R:M174 R:R:M177 4.33 1 Yes Yes 4 6 2 1
R:R:M174 R:R:N253 9.82 1 Yes No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 5.81 1 No Yes 5 6 2 2
R:R:M177 R:R:N253 4.21 1 Yes No 6 5 1 1
L:L:?1 R:R:M177 6.85 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes No 6 5 1 2
R:R:F182 R:R:H250 24.89 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 9.69 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 12.03 0 Yes Yes 9 8 2 1
R:R:S277 R:R:W246 12.36 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 11.04 1 Yes Yes 0 8 0 1
R:R:I274 R:R:L249 4.28 1 No No 4 5 1 1
L:L:?1 R:R:L249 15.66 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 6.23 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 9.62 1 Yes No 0 5 0 1
L:L:?1 R:R:Y271 5.68 1 Yes No 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 16.91 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:L267 R:R:Y271 2.34 0 No No 3 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
86.67Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
73.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
66.67Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
66.67Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
60.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
58.82Single7TUYGSK682753A7TUY-GPR183-GSK682753A
58.82Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
57.14Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
55.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
53.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
52.94Single5NM2ZM2413855NM2-A2A-ZM241385-Na
52.94Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
52.94Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
50.00Single3REYPubChem 56973REY-A2A-PubChem 5697
50.00Single6AQFZM2413856AQF-A2A-ZM241385
50.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
50.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
50.00Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
50.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
47.62Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
47.37Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
47.37Single7YITNalfurafine7YIT-κ-Nalfurafine
47.37Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
47.37Single8JJLOlodaterol8JJL-β2-Olodaterol
47.37Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
47.37Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
47.06Single3NY8ICI 118-5513NY8-β2-ICI 118-551
47.06Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
47.06Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
47.06Single4EIYZM2413854EIY-A2A-ZM241385-Na
47.06Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
47.06Single5IU8Q274563475IU8-A2A-Q27456347-Na
47.06Single5OLGZM2413855OLG-A2A-ZM241385-Na
47.06Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
47.06Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
47.06Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
47.06Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
47.06Single7PYRPSB-21157PYR-A2A-PSB-2115
47.06Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
47.06Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
47.06Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
47.06Single8CU6LJ-45178CU6-A2A-LJ-4517
47.06Single8JJOAlprenolol8JJO-β2-Alprenolol
47.06Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
47.06Consensusa2_offOrthosteric Liganda2a_off
47.06Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
46.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
45.45Single3QAKUK-4320973QAK-A2A-UK-432097
45.45Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
45.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
45.00Single6H7LDobutamine6H7L-β1-Dobutamine
45.00Single7EZCUKA7EZC-A2A-UKA
45.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
45.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
45.00Consensusendothelin_offOrthosteric Ligandetb_off
45.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
44.44Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
44.44Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
44.44Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
44.44Single5IUAQ274563485IUA-A2A-Q27456348-Na
44.44Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
44.44Single6E67BI1671076E67-β2-BI167107-Gs (fused)
44.44Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
44.44Single6LPLZM2413856LPL-A2A-ZM241385-Na
44.44Single6PS6Timolol6PS6-β2-Timolol
44.44Single6S0QZM2413856S0Q-A2A-ZM241385
44.44Single6WQAZM2413856WQA-A2A-ZM241385-Na
44.44Single7RM5ZM2413857RM5-A2A-ZM241385-Na
44.44Single8FYNZM2413858FYN-A2A-ZM241385-Na
44.44Single8GNEKW-63568GNE-A2A-KW-6356-Na
44.44Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
44.44Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
44.44Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
44.44Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
44.44Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
44.44Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
43.75Single3PWHZM2413853PWH-A2A-ZM241385
43.75Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
43.75Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
43.75Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
43.75Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
43.48Single6PT2KGCHM076PT2-δ-KGCHM07
42.86Single3NY9PubChem 9131033NY9-β2-PubChem 913103
42.86Single4UG2CGS216804UG2-A2A-CGS21680
42.86Single7SK9CCX6627SK9-ACKR3-CCX662
42.86Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
42.86Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
42.86Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
42.11Single2YDVNECA2YDV-A2A-NECA
42.11Single3P0GBI1671073P0G-β2-BI167107
42.11Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
42.11Single4UHRCGS216804UHR-A2A-CGS21680
42.11Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
42.11Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
42.11Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
42.11Single5G53NECA5G53-A2A-NECA-Gs
42.11Single6J20Aprepitant6J20-NK1-Aprepitant
42.11Single6J21Aprepitant6J21-NK1-Aprepitant
42.11Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
42.11Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
42.11Single6TQ7SB-3348676TQ7-OX1-SB-334867
42.11Single7PX4PSB-21137PX4-A2A-PSB-2113
42.11Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
42.11Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
42.11Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
42.11Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
42.11Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
42.11Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
42.11Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
42.11Consensusa2_onOrthosteric Liganda2a_on a2b_on
42.11Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
42.11Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
42.11Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
41.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
41.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
41.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
41.18Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
41.18Single5IU4ZM2413855IU4-A2A-ZM241385-Na
41.18Single5IU7Q274563465IU7-A2A-Q27456346-Na
41.18Single5IUBQ274563445IUB-A2A-Q27456344-Na
41.18Single5JTBZM2413855JTB-A2A-ZM241385
41.18Single5K2CZM2413855K2C-A2A-ZM241385-Na
41.18Single5NM4ZM2413855NM4-A2A-ZM241385-Na
41.18Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
41.18Single6PS4ICI 118-5516PS4-β2-ICI 118-551
41.18Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
41.18Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
41.18Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
41.18Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
41.18Single7T32ZM2413857T32-A2A-ZM241385
41.18Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGKEpinephrine8GGK-β2-Epinephrine
41.18Single8GGMEpinephrine8GGM-β2-Epinephrine
41.18Single8GGPEpinephrine8GGP-β2-Epinephrine
41.18Single8GGQEpinephrine8GGQ-β2-Epinephrine
41.18Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
41.18Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
41.18Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
41.18Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
41.18Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
40.91Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
40.91Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.74Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
40.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
40.00Single3UZAGTPL92363UZA-A2A-GTPL9236
40.00Single4AMIBucindolol4AMI-β1-Bucindolol
40.00Single4LDEBI1671074LDE-β2-BI167107
40.00Single6A93Risperidone6A93-5-HT2A-Risperidone
40.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
40.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
40.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
40.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8JJ8Formoterol8JJ8-β2-Formoterol
40.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
40.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
40.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
40.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
40.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
39.29Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.29Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.13Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
39.13Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
39.13Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
39.13Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
38.89Single3EMLZM2413853EML-A2A-ZM241385
38.89Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
38.89Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
38.89Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.89Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
38.89Single5K2AZM2413855K2A-A2A-ZM241385-Na
38.89Single5UENDU1725UEN-A1-DU172
38.89Single5VRAZM2413855VRA-A2A-ZM241385-Na
38.89Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
38.89Single6LPJZM2413856LPJ-A2A-ZM241385-Na
38.89Single6LPKZM2413856LPK-A2A-ZM241385-Na
38.89Single6PS1Timolol6PS1-β2-Timolol
38.89Single6S0LZM2413856S0L-A2A-ZM241385
38.89Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
38.89Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
38.89Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
38.89Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
38.89Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
38.89Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
38.89Single7WC7Lisuride7WC7-5-HT2A-Lisuride
38.89Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
38.89Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGJEpinephrine8GGJ-β2-Epinephrine
38.89Single8GGNEpinephrine8GGN-β2-Epinephrine
38.89Single8GGOEpinephrine8GGO-β2-Epinephrine
38.89Single8GGUEpinephrine8GGU-β2-Epinephrine
38.89Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
38.89Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
38.89Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
38.89Single8X63Mepyramine8X63-H1-Mepyramine
38.89Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
38.89Consensusadenosine_onOrthosteric Liganda1_on a2_on
38.89Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
38.89Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
38.89Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
38.89Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
38.89Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
38.89Consensusblt_onOrthosteric Ligandblt1_on
38.89Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.89Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
38.89Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
38.89Consensusleuko_onOrthosteric Ligandblt_on
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.89Consensustachykinin_offOrthosteric Ligandnk1_off
38.10Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
38.10Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
38.10Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.10Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.10Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.10Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.10Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.10Single6IBLArformoterol6IBL-β1-Arformoterol
38.10Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.10Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
38.10Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.10Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
38.10Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
38.10Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
38.10Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
38.10Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
38.10Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.10Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.10Consensussteroid_onOrthosteric Ligandbileacid_on
37.50Single5WF5UK-4320975WF5-A2A-UK-432097
37.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
37.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
37.50Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8GGSEpinephrine8GGS-β2-Epinephrine
37.50Single8GGYEpinephrine8GGY-β2-Epinephrine
37.50Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
37.50Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
36.84Single2Y00Dobutamine2Y00-β1-Dobutamine
36.84Single5C1MBU725C1M-μ-BU72
36.84Single5N2SPSB365N2S-A1-PSB36
36.84Single5TVNLSD5TVN-5-HT2B-LSD
36.84Single5WIUNemonapride5WIU-D4-Nemonapride
36.84Single5WIVNemonapride5WIV-D4-Nemonapride-Na
36.84Single6D26Fevipiprant6D26-DP2-Fevipiprant
36.84Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
36.84Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
36.84Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
36.84Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
36.84Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
36.84Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
36.84Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
36.84Single7WC6LSD7WC6-5-HT2A-LSD
36.84Single7XKAEpinephrine7XKA-β2-Epinephrine
36.84Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
36.84Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
36.84Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
36.84Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
36.84Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
36.84Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
36.84Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
36.84Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
36.84Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
36.84Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
36.84Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
36.84Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
36.84Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
36.84Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
36.84Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
36.84Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single5WF6UK-4320975WF6-A2A-UK-432097
36.36Single5ZTYAM102575ZTY-CB2-AM10257
36.36Single6PT3DPI-2876PT3-δ-DPI-287
36.36Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
36.36Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.36Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.36Consensuslpl_offOrthosteric Ligands1p_off lpa_off
36.36Consensuslpl_onOrthosteric Ligands1p_on lpa_on
36.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
35.29Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
35.29Single5DHHSB-6121115DHH-NOP-SB-612111
35.29Single5K2DZM2413855K2D-A2A-ZM241385
35.29Single6AKXA4R6AKX-CCR5-A4R
35.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
35.29Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
35.29Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
35.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
35.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.29Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
35.29Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
35.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGVEpinephrine8GGV-β2-Epinephrine
35.29Single8GGXEpinephrine8GGX-β2-Epinephrine
35.29Single8GH0Epinephrine8GH0-β2-Epinephrine
35.29Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
35.29Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
35.29Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
35.29Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
35.29Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
35.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
35.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
35.00Single5X93K-87945X93-ETB-K-8794
35.00Single6E59L-7607356E59-NK1-L-760735
35.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
35.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.00Single6WGTLSD6WGT-5-HT2A-LSD
35.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
35.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
35.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
35.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
35.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
35.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
35.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
35.00Single8E0GBU728E0G-μ-BU72
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
35.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
35.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
35.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
35.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
35.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
35.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
35.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
35.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
35.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
35.00Consensushistamine_offOrthosteric Ligandh1_off
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
34.78Single4IARErgotamine4IAR-5-HT1B-Ergotamine
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
34.78Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
34.78Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.62Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
33.33Single2YDOAdenosine2YDO-A2A-Adenosine
33.33Single3RFMCaffeine3RFM-A2A-Caffeine
33.33Single3RZECidoxepin3RZE-H1-Cidoxepin
33.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
33.33Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single5K2BZM2413855K2B-A2A-ZM241385-Na
33.33Single5NLXZM2413855NLX-A2A-ZM241385-Na
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single5UVIZM2413855UVI-A2A-ZM241385
33.33Single6A94Zotepine6A94-5-HT2A-Zotepine
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6HLOAprepitant6HLO-NK1-Aprepitant
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6MH8ZM2413856MH8-A2A-ZM241385
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single6TPNHTL66416TPN-OX2-HTL6641
33.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
33.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7K15MKD0467K15-BLT1-MKD046-Na
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
33.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGIEpinephrine8GGI-β2-Epinephrine
33.33Single8GGLEpinephrine8GGL-β2-Epinephrine
33.33Single8GGTEpinephrine8GGT-β2-Epinephrine
33.33Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
33.33Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
33.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
33.33Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
33.33Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
33.33Consensusblt_offOrthosteric Ligandblt1_off
33.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
33.33Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
33.33Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
33.33Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
33.33Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
33.33Consensuss1p_offOrthosteric Ligands1p1_off
33.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
32.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
32.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
32.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
32.00Consensusangiotensin_onOrthosteric Ligandat1_on
32.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
31.82Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
31.82Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
31.82Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.82Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
31.82Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
31.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.82Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
31.82Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.82Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
31.82Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.82Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
31.82Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
31.82Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
31.82Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
31.82Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
31.82Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
31.82Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusorexin_onOrthosteric Ligandox2_on
31.58Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
31.58Single2Y01Dobutamine2Y01-β1-Dobutamine
31.58Single2Y02Carmoterol2Y02-β1-Carmoterol
31.58Single2Y04Salbutamol2Y04-β1-Salbutamol
31.58Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
31.58Single4DAJTiotropium4DAJ-M3-Tiotropium
31.58Single4MQSIperoxo4MQS-M2-Iperoxo
31.58Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
31.58Single4U14Tiotropium4U14-M3-Tiotropium
31.58Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
31.58Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
31.58Single5DSGTiotropium5DSG-M4-Tiotropium
31.58Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.58Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
31.58Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
31.58Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
31.58Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
31.58Single6H7MSalbutamol6H7M-β1-Salbutamol
31.58Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
31.58Single7BU7BI1671077BU7-β1-BI167107
31.58Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
31.58Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.58Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
31.58Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.58Single7UL4Alvimopan7UL4-μ-Alvimopan
31.58Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
31.58Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
31.58Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.58Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8K5DGSK2560738K5D-HCA2-GSK256073
31.58Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Single8X64Desloratadine8X64-H1-Desloratadine
31.58Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
31.58Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
31.58Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
31.58Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Consensusgi_hcarOrthosteric Ligandgi_hca
31.58Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
31.58Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Consensushistamine_onOrthosteric Ligandh1_on h4_on
31.58Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
31.58Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
31.58Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
31.58Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.58Consensustar_onOrthosteric Ligandta1_on
31.25Single8GGREpinephrine8GGR-β2-Epinephrine
31.25Single8GGZEpinephrine8GGZ-β2-Epinephrine
31.25Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
31.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single6IGLIRL16206IGL-ETB-IRL1620
31.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
31.03Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
30.77Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.77Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
30.77Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.43Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.43Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
30.43Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
30.43Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
30.43Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.00Single5WQCEMPA5WQC-OX2-EMPA
30.00Single5XPRBosentan5XPR-ETB-Bosentan
30.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
30.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Single7C4SS1P7C4S-S1P3-S1P
30.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
30.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
30.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
30.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
30.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
30.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8EA0Iperoxo8EA0-M3-Iperoxo
30.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.00Single8QOTNanobody E8QOT-μ-Nanobody E
30.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
30.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
30.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
30.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
29.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
29.63Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
29.41Single3PBLEticlopride3PBL-D3-Eticlopride
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single6HLLCP999946HLL-NK1-CP99994
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7SRQLSD7SRQ-5-HT2B-LSD
29.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
29.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
29.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
29.41Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GH1Epinephrine8GH1-β2-Epinephrine
29.41Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
29.41Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8K5BNiacin8K5B-HCA2-Niacin
29.41Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
29.41Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
29.17Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
29.17Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
29.17Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
29.17Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
29.03Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
29.03Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
28.57Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
28.57Single4DJHJDTic4DJH-κ-JDTic
28.57Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
28.57Single4RWADIPP-NH24RWA-δ-DIPP-NH2
28.57Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
28.57Single4U15Tiotropium4U15-M3-Tiotropium
28.57Single5MZPCaffeine5MZP-A2A-Caffeine-Na
28.57Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
28.57Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
28.57Single6OL9Tiotropium6OL9-M5-Tiotropium
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
28.57Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
28.57Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
28.57Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
28.57Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
28.57Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
28.57Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single7W41PD1762527W41-BB2-PD176252
28.57Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
28.57Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.57Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
28.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
28.57Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
28.57Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.57Consensusbombesin_offOrthosteric Ligandbb2_off
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.57Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
28.57Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
28.57Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
28.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
28.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
28.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
27.78Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
27.78Single6AKYMaraviroc6AKY-CCR5-Maraviroc
27.78Single6B73PubChem 1319551386B73-κ-PubChem 131955138
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single6KUXRS-799486KUX-α2a-RS-79948
27.78Single6ME2Ramelteon6ME2-MT1-Ramelteon
27.78Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
27.78Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
27.78Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
27.78Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.78Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.78Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
27.78Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
27.78Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGWEpinephrine8GGW-β2-Epinephrine
27.78Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8IWESpermidine8IWE-TAAR9-Spermidine
27.78Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
27.78Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
27.78Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
27.78Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
27.78Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
27.78Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusmglu_onOther Ligandmglu2_on mglu4_on
27.78Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.59Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
27.59Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single4N4WSANT-14N4W-SMO-SANT-1
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single5CXVTiotropium5CXV-M1-Tiotropium
27.27Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6HLPNetupitant6HLP-NK1-Netupitant
27.27Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
27.27Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.27Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.27Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.27Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
27.27Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.27Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
27.27Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.27Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
27.27Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.27Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
27.27Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
27.27Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
27.27Consensusclass-b2_onOrthosteric Ligandadgrg_on
27.27Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.27Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
26.92Single6W25SHU91196W25-MC4-SHU9119-Ca
26.92Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.92Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
26.92Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.92Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single4ZJCSB-6740424ZJC-OX1-SB-674042
26.32Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.32Single6TPKRetosiban6TPK-OT-Retosiban
26.32Single6V9SGTPL114036V9S-OX1-GTPL11403
26.32Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.32Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.32Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.32Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.32Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
26.32Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.32Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
26.32Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.32Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
26.32Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
26.32Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.32Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.32Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.32Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.32Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.32Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.32Consensushcar_onOrthosteric Ligandhca_on
26.32Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.32Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
26.32Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.09Single6K1QIRL25006K1Q-ETB-IRL2500
26.09Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
26.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
26.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
26.09Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
26.09Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
26.09Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
26.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
25.93Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
25.93Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.93Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.93Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.93Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
25.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
25.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
25.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
25.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
25.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
24.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.14Single4XT3Fractalkine4XT3-US28-Fractalkine
24.14Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
24.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
24.14Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.14Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
24.14Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
24.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
24.00Single4XT1Fractalkine4XT1-US28-Fractalkine
24.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
24.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
24.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
24.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
23.81Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.81Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.81Single6GPXMK08126GPX-CCR2-MK0812
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.81Single6TP6Filorexant6TP6-OX1-Filorexant
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.81Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
23.81Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.81Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.81Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.53Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.53Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
23.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
23.08Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.08Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.08Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
23.08Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
22.73Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.73Single5V56TC1145V56-SMO-TC114
22.73Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.73Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
22.73Single7EPENAM5637EPE-mGlu-NAM563
22.73Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.73Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
22.73Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
22.73Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.73Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.73Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.73Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.73Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.73Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
22.73Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
22.73Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
22.73Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.73Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
22.73Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.73Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.73Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.58Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
22.58Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
22.58Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.58Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.22Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.22Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
22.22Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.22Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
22.22Single3OE9IT1t3OE9-CXCR4-IT1t
22.22Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
22.22Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.22Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
22.22Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
22.22Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
22.22Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.22Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
22.22Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
21.88Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
21.88Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.74Single5X33BIIL2605X33-BLT1-BIIL260
21.74Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.74Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.74Single6OS2TRV0266OS2-AT1-TRV026
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.74Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
21.74Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.74Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.74Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.74Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.74Consensusgi_class-fOther Ligandgi_frizzled
21.74Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.74Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.74Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
21.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
21.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
21.21Consensusglp_onOrthosteric Ligandglp1_on glp2_on
21.05Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.05Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.05Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single5WS3EMPA5WS3-OX2-EMPA
21.05Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.05Single6TODEMPA6TOD-OX1-EMPA-Na
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8IHKAcifran8IHK-HCA3-Acifran
21.05Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.05Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.05Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.05Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
20.83Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.83Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.83Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.83Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.83Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.83Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.69Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
20.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
20.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
20.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
20.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
20.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
20.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensussensory_offOrthosteric Ligandopsin_off
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.44Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
19.35Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
19.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
19.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
19.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
19.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.35Consensusgo_class-b1Orthosteric Ligandgo_crf
19.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
19.23Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
19.23Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.23Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.23Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.23Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.23Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.05Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.05Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.05Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
19.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
19.05Single6IIVDaltroban6IIV-TP-Daltroban
19.05Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
19.05Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
19.05Single7F83PF-051904577F83-Ghrelin-PF-05190457
19.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
19.05Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
19.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
19.05Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
19.05Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
19.05Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
19.05Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
19.05Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.75Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.75Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.75Consensusclass-c_onOther Ligandgabab_on mglu_on
18.75Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.75Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.52Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
18.52Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.52Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.52Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.52Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
18.18Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
18.18Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.18Single5CGCHTL142425CGC-mGlu5-HTL14242
18.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.18Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.18Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
18.18Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
18.18Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.18Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
18.18Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
18.18Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
18.18Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
18.18Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
18.18Consensusep_offOrthosteric Ligandep4_off
17.86Single3OE0CVX153OE0-CXCR4-CVX15
17.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.86Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.86Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
17.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.65Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.65Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.65Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.65Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
17.65Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
17.65Consensussensory_onOrthosteric Ligandopsin_on
17.39Single5V57TC1145V57-SMO-TC114
17.39Single5XR8AM8415XR8-CB1-AM841
17.39Single5XRAAM115425XRA-CB1-AM11542
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.39Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
17.39Single7P2L4YI7P2L-mGlu5-4YI
17.39Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
17.39Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.39Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
17.39Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.39Consensuschemerin_onOrthosteric Ligandcml1_on
17.39Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.39Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.39Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.24Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
17.24Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.14Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
17.14Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.14Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.14Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
17.07Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
16.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
16.67Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
16.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
16.67Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.67Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.13Single6FJ3PTH6FJ3-PTH1-PTH
16.13Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.13Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.13Consensusclass-d_onOrthosteric Ligandste2_on
16.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.00Single5CGDHTL142425CGD-mGlu5-HTL14242
16.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.79Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.79Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.62Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
15.62Consensusgi_class-dOrthosteric Ligandgi_ste
15.62Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
15.38Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
15.38Consensusclass-d_offOrthosteric Ligandste2_off
15.38Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.38Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
15.38Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single6LMLGlucagon6LML-Glucagon-Glucagon
15.15Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.15Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.15Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
15.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
15.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
15.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
15.00Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.00Consensusgt_class-aOrthosteric Ligandgt_opsin
15.00Consensusgt_opsinOrthosteric Ligandgt_sensory
15.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.81Single7QA8Peptide7QA8-STE2-Peptide
14.81Single7QA8Peptide7QA8-STE2-Peptide
14.81Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.81Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.81Consensusclass-d_offOrthosteric Ligandste2_off
14.71Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single6FFIMMPEP6FFI-mGlu5-MMPEP
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.29Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
14.29Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
14.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgnrh_offOrthosteric Ligandgnrh1_off
14.29Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
14.29Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensussst_offOrthosteric Ligandsst2_off
13.89Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.79Single7XNACYN1548067XNA-SST2-CYN154806
13.79Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.79Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
13.79Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.79Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
13.79Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.64Single5TGZAM65385TGZ-CB1-AM6538
13.64Single6FFHFenobam6FFH-mGlu5-Fenobam
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.64Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
13.64Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.64Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.64Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.64Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.64Consensushcar_offOrthosteric Ligandsuccinate_off
13.64Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.33Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Consensusclass-d_onOrthosteric Ligandste2_on
13.33Consensusgi_class-dOrthosteric Ligandgi_ste
13.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.33Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.16Consensuspth_onOrthosteric Ligandpth1_on pth2_on
13.04Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.04Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.04Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
13.04Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.04Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.04Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.90Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.90Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
12.90Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.90Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.90Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single5TZR-5TZR-FFA1 (GPR40)-MK8666
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7SK3CXCL127SK3-ACKR3-CXCL12
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
12.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.50Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.12Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.12Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.00Single4XESNeurotensin4XES-NTS1-Neurotensin
12.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.00Consensuschemokine_offOrthosteric Ligandcxcr_off
12.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
12.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusnts_offOrthosteric Ligandnts1_off
12.00Consensusnts_onOrthosteric Ligandnts1_on
12.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
11.76Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
11.76Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
11.76Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.76Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.54Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.54Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.54Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
11.54Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.54Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
11.54Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.54Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.54Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.54Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.54Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.43Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.43Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.11Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.11Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
11.11Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.11Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
10.71Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.71Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.53Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.53Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.53Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
10.53Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
10.53Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.53Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.53Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
10.34Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.34Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.34Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.26Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
9.68Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.52Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.52Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.52Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
9.52Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
9.52Consensusclass-f_offOrthosteric Ligandsmo_off
9.52Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.52Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.30Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.09Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.09Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.09Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09Single7VV6C48/807VV6-MRGPRX2-C48/80
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.09Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
9.09Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.82Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
8.82Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.57Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
8.57Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
8.57Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
8.57Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
8.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.69Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.69Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.69Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.41Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.45Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single6W25Ca6W25-MC4-SHU9119-Ca
5.88Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
5.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.41Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.26Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.26Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7UL2SR486927UL2-NTS1-SR48692-Na
4.76Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.76Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.76Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusclass-t_onOrthosteric Ligandtaste2_on
4.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
4.76Consensusgs_class-tOrthosteric Ligandgs_taste
4.76Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.76Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.76Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single5U09Taranabant5U09-CB1-Taranabant
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.55Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6ZINSR486926ZIN-NTS1-SR48692
4.35Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8IYXYL-3658IYX-GPR34-YL-365
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.35Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single5T04Neurotensin5T04-NTS1-Neurotensin
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.17Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single6KNMJN241-96KNM-Apelin-JN241-9
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.23Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.08Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8JWZ
Class A
SubFamily Nucleotide
Type Adenosine
SubType A2A
Species Homo Sapiens
Ligand AB928
Other Ligand(s) Na
Protein Partners -
PDB Resolution 2.37
Date 2023-08-16
D.O.I. 10.1007/s11427-023-2459-8
Net Summary
Imin 3.07
Number of Linked Nodes 265
Number of Links 312
Number of Hubs 48
Number of Links mediated by Hubs 173
Number of Communities 10
Number of Nodes involved in Communities 75
Number of Links involved in Communities 105
Path Summary
Number Of Nodes in MetaPath 66
Number Of Links MetaPath 65
Number of Shortest Paths 71117
Length Of Smallest Path 3
Average Path Length 15.4233
Length of Longest Path 36
Minimum Path Strength 1.415
Average Path Strength 6.7695
Maximum Path Strength 21.575
Minimum Path Correlation 0.7
Average Path Correlation 0.928485
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 43.6715
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.1067
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNA
PDB ResiduesI:I:?1
Environment DetailsOpen EMBL-EBI Page
CodeNA
NameSODIUM ION
Synonyms
Identifiersodium(+1) cation
FormulaNa
Molecular Weight22.99
SMILES[Na+]
PubChem
Formal Charge1
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodeU30
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeU30
NameEtrumadenant
SynonymsEtrumadenant
Identifier3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile
FormulaC23 H22 N8 O
Molecular Weight426.474
SMILESCc1c(cccc1c2cc(nc(n2)N)c3cn(nn3)Cc4cccc(n4)C(C)(C)O)C#N
PubChem135242184
Formal Charge0
Total Atoms54
Total Chiral Atoms0
Total Bonds57
Total Aromatic Bonds23

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP29274
Sequence
>8JWZ_Chain_R
IMGSSVYIT VELAIAVLA ILGNVLVCW AVWLNSNLQ NVTNYFVVS 
LAAADIAVG VLAIPFAIT ISTGFCAAC HGCLFIACF VLVLTQSSI 
FSLLAIAID RYIAIRIPL RYNGLVTGT RAKGIIAIC WVLSFAIGL 
TPMLGWNNC GQPKSQGCG EGQVACLFE DVVPMNYMV YFNFFACVL 
VPLLLMLGV YLRIFLAAR RQLRSTLQK EVHAAKSLA IIVGLFALC 
WLPLHIINC FTFFCPDCS HAPLWLMYL AIVLSHTNS VVNPFIYAY 
RIREFRQTF RKIIRSHVL RQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
a2a_off_allo6ZDR-A2A-HMS1413f12-Na
6GT3-A2A-Imaradenant-Na
8CU7-A2A-LJ-4517-Na
5OLV-A2A-LUAA41063-Na
5N2R-A2A-PubChem 92460631; psb36-Na
5MZJ-A2A-Theophylline-Na
5OLO-A2A-Tozadenant-Na
5OLH-A2A-Vipadenant-Na
5NM4-A2A-ZM241385-Na
8GNE-A2A-KW-6356-Na
8JWZ-A2A-AB928-Na
5MZP-A2A-Caffeine-Na
8CIC-A2A-Etrumadenant-Na

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2YDOANucleotideAdenosineA2AHomo sapiensAdenosine--32011-05-1810.1038/nature10136
2YDVANucleotideAdenosineA2AHomo sapiensNECA--2.62011-05-1810.1038/nature10136
3EMLANucleotideAdenosineA2AHomo sapiensZM241385--2.62008-10-1410.1126/science.1164772
3PWHANucleotideAdenosineA2AHomo sapiensZM241385--3.32011-09-0710.1016/j.str.2011.06.014
3QAKANucleotideAdenosineA2AHomo sapiensUK-432097--2.712011-03-0910.1126/science.1202793
3REYANucleotideAdenosineA2AHomo sapiensPubChem 5697--3.312011-09-0710.1016/j.str.2011.06.014
3RFMANucleotideAdenosineA2AHomo sapiensCaffeine--3.62011-09-0710.1016/j.str.2011.06.014
3UZAANucleotideAdenosineA2AHomo sapiensGTPL9236--3.272012-03-2110.1021/jm201376w
3UZCANucleotideAdenosineA2AHomo sapiensPubChem 135566609--3.342012-03-2110.1021/jm201376w
3VG9ANucleotideAdenosineA2AHomo sapiensZM241385Antibody-2.72012-02-0110.1038/nature10750
3VGAANucleotideAdenosineA2AHomo sapiensZM241385Antibody-3.12012-02-0110.1038/nature10750
4EIYANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82012-07-2510.1126/science.1219218
4UG2ANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
4UHRANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
5G53ANucleotideAdenosineA2AHomo sapiensNECA-Gs3.42016-08-0310.1038/nature18966
5IU4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.722016-06-2910.1021/acs.jmedchem.6b00653
5IU7ANucleotideAdenosineA2AHomo sapiensQ27456346Na-1.92016-06-2910.1021/acs.jmedchem.6b00653
5IU8ANucleotideAdenosineA2AHomo sapiensQ27456347Na-22016-06-2910.1021/acs.jmedchem.6b00653
5IUAANucleotideAdenosineA2AHomo sapiensQ27456348Na-2.22016-06-2910.1021/acs.jmedchem.6b00653
5IUBANucleotideAdenosineA2AHomo sapiensQ27456344Na-2.12016-06-2910.1021/acs.jmedchem.6b00653
5JTBANucleotideAdenosineA2AHomo sapiensZM241385--2.82017-05-3110.1126/sciadv.1602952
5K2AANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2BANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2CANucleotideAdenosineA2AHomo sapiensZM241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2DANucleotideAdenosineA2AHomo sapiensZM241385--1.92016-09-2110.1126/sciadv.1600292
5MZJANucleotideAdenosineA2AHomo sapiensTheophyllineNa-22017-07-2610.1016/j.str.2017.06.012
5MZPANucleotideAdenosineA2AHomo sapiensCaffeineNa-2.12017-07-2610.1016/j.str.2017.06.012
5N2RANucleotideAdenosineA2AHomo sapiensPubChem 92460631; psb36Na-2.82017-07-2610.1016/j.str.2017.06.012
5NLXANucleotideAdenosineA2AHomo sapiensZM241385Na-2.142017-09-2710.1038/s41467-017-00630-4
5NM2ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.952017-09-2710.1038/s41467-017-00630-4
5NM4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5OLGANucleotideAdenosineA2AHomo sapiensZM241385Na-1.872018-01-1710.1038/s41598-017-18570-w
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5OLOANucleotideAdenosineA2AHomo sapiensTozadenantNa-3.12018-01-1710.1038/s41598-017-18570-w
5OLVANucleotideAdenosineA2AHomo sapiensLUAA41063Na-22018-01-1710.1038/s41598-017-18570-w
5OLZANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-1.92018-01-1710.1038/s41598-017-18570-w
5OM1ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-2.12018-01-1710.1038/s41598-017-18570-w
5OM4ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-22018-01-1710.1038/s41598-017-18570-w
5UIGANucleotideAdenosineA2AHomo sapiensJ3.651.884G--3.52017-02-0810.1073/pnas.1621423114
5UVIANucleotideAdenosineA2AHomo sapiensZM241385--3.22017-05-2410.1107/S205225251700570X
5VRAANucleotideAdenosineA2AHomo sapiensZM241385Na-2.352017-12-1310.1038/nprot.2017.135
5WF5ANucleotideAdenosineA2AHomo sapiensUK-432097--2.62018-02-2110.1016/j.str.2017.12.013
5WF6ANucleotideAdenosineA2AHomo sapiensUK-432097--2.92018-02-2110.1016/j.str.2017.12.013
6AQFANucleotideAdenosineA2AHomo sapiensZM241385--2.512018-01-1010.1016/j.cell.2017.12.004
6GDGANucleotideAdenosineA2AHomo sapiensNECA-Gs/&β;1/&γ;14.112018-05-1610.7554/eLife.35946
6GT3ANucleotideAdenosineA2AHomo sapiensImaradenantNa-22019-06-2610.1136/jitc-2019-000417
6JZHANucleotideAdenosineA2AHomo sapiensZM241385Na-2.252019-10-3010.1107/S1600576719012846
6LPJANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPKANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPLANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-2510.1038/s41598-020-76277-x
6MH8ANucleotideAdenosineA2AHomo sapiensZM241385--4.22019-04-2410.1107/S205225251900263X
6PS7ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.852019-11-1310.1107/S2052252519013137
6S0LANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6S0QANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6WQAANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-1810.1107/S2052252520012701
6ZDRANucleotideAdenosineA2AHomo sapiensHMS1413f12Na-1.922020-09-1610.1002/anie.202003788
6ZDVANucleotideAdenosineA2AHomo sapiensPubChem 984073Na-2.132020-09-1610.1002/anie.202003788
7AROANucleotideAdenosineA2AHomo sapiensLUF5833Na-3.122021-04-0710.1021/acs.jmedchem.0c01856
7EZCANucleotideAdenosineA2AHomo sapiensUKA--3.82022-04-1310.1107/S2052252522001907
7PX4ANucleotideAdenosineA2AHomo sapiensPSB-2113--2.252022-03-0210.1002/anie.202115545
7PYRANucleotideAdenosineA2AHomo sapiensPSB-2115--2.62022-03-0210.1002/anie.202115545
7RM5ANucleotideAdenosineA2AHomo sapiensZM241385Na-2.792021-09-0810.1073/pnas.2106041118
7T32ANucleotideAdenosineA2AHomo sapiensZM241385--3.42022-08-1010.1038/s41467-022-32125-2
8A2OANucleotideAdenosineA2AHomo sapiensTheophyllineNa-3.452023-08-3010.1107/S1600576723006428
8A2PANucleotideAdenosineA2AHomo sapiensLUAA47070Na-3.52023-08-3010.1107/S1600576723006428
8C9WANucleotideAdenosineA2AHomo sapiensEtrumadenant--2.112023-07-1210.1038/s42004-023-00894-6
8CICANucleotideAdenosineA2AHomo sapiensEtrumadenantNa-2.12023-05-3110.1038/s42004-023-00894-6
8CU6ANucleotideAdenosineA2AHomo sapiensLJ-4517--2.82022-08-3110.1021/acs.jmedchem.2c00462
8CU7ANucleotideAdenosineA2AHomo sapiensLJ-4517Na-2.052022-08-3110.1021/acs.jmedchem.2c00462
8DU3ANucleotideAdenosineA2AHomo sapiensPubChem 105526064--2.52022-08-1010.1016/j.ejmech.2022.114620
8FYNANucleotideAdenosineA2AHomo sapiensZM241385Na-22023-03-0810.1038/s41467-023-36733-4
8GNEANucleotideAdenosineA2AHomo sapiensKW-6356Na-2.32023-03-2210.1124/molpharm.122.000633
8GNGANucleotideAdenosineA2AHomo sapiensIstradefylline--3.22023-03-2210.1124/molpharm.122.000633
8JWYANucleotideAdenosineA2AHomo sapiensPubChem 168451710--2.332023-08-1610.1007/s11427-023-2459-8
8PWNANucleotideAdenosineA2AHomo sapiensTheophylline--2.752023-10-2510.1038/s42004-023-01014-0




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