Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8C9W | A | Nucleotide | Adenosine | A2A | Homo Sapiens | Etrumadenant | - | - | 2.11 | 2023-07-12 | 10.1038/s42004-023-00894-6 |
![](/psngpcr/ligands/U30/U30_8C9W_L_L_1.png)
A 2D representation of the interactions of U30 in 8C9W colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 17.96 | 1 | Yes | Yes | 6 | 5 | 2 | 1 | R:R:S67 | R:R:Y9 | 3.82 | 1 | No | Yes | 3 | 5 | 1 | 1 | R:R:Y271 | R:R:Y9 | 9.93 | 0 | Yes | Yes | 3 | 5 | 2 | 1 | L:L:?1 | R:R:Y9 | 6.31 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E13 | R:R:H278 | 13.54 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:A59 | R:R:V84 | 3.39 | 0 | No | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:S67 | 7.28 | 1 | Yes | No | 0 | 3 | 0 | 1 | L:L:?1 | R:R:V84 | 3.21 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:L85 | R:R:Y176 | 3.52 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:L85 | R:R:M177 | 4.24 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:L85 | R:R:N181 | 4.12 | 1 | Yes | No | 4 | 5 | 1 | 2 | L:L:?1 | R:R:L85 | 6.71 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T88 | R:R:W246 | 7.28 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:T88 | 4.76 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F168 | R:R:V172 | 13.11 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 6.22 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 27.55 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M174 | R:R:N253 | 8.41 | 0 | Yes | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 10.47 | 1 | No | Yes | 5 | 6 | 2 | 2 | R:R:M177 | R:R:N253 | 4.21 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:M177 | 6.09 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 29.41 | 1 | Yes | No | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 1 | No | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 11.02 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:S277 | R:R:W246 | 14.83 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 13.5 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:A273 | R:R:L249 | 4.73 | 0 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:L249 | 11.18 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 6.23 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 9.62 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 2 | 1 | L:L:?1 | R:R:I274 | 14.61 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H278 | R:R:S277 | 4.18 | 1 | Yes | No | 6 | 7 | 2 | 2 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.75 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 33.00 |
| ![](/psngpcr/ligands/U30/U30_8C9W_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/U30/U30_8C9W_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8CIC | A | Nucleotide | Adenosine | A2A | Homo sapiens | Etrumadenant | Na | - | 2.1 | 2023-05-31 | 10.1038/s42004-023-00894-6 |
![](/psngpcr/ligands/U30/U30_8CIC_L_L_1.png)
A 2D representation of the interactions of U30 in 8CIC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E13 | R:R:Y9 | 17.96 | 1 | Yes | Yes | 6 | 5 | 2 | 1 | R:R:S67 | R:R:Y9 | 5.09 | 1 | No | Yes | 3 | 5 | 1 | 1 | R:R:Y271 | R:R:Y9 | 14.89 | 0 | No | Yes | 3 | 5 | 2 | 1 | L:L:?1 | R:R:Y9 | 6.95 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E13 | R:R:H278 | 13.54 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:A59 | R:R:V84 | 3.39 | 0 | No | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:S67 | 5.66 | 1 | Yes | No | 0 | 3 | 0 | 1 | L:L:?1 | R:R:V84 | 4.01 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:G136 | R:R:L85 | 3.42 | 0 | No | Yes | 6 | 4 | 2 | 1 | R:R:L85 | R:R:Y176 | 3.52 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:L85 | R:R:M177 | 4.24 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:L85 | R:R:N181 | 6.87 | 1 | Yes | No | 4 | 5 | 1 | 2 | L:L:?1 | R:R:L85 | 5.96 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:F168 | R:R:V172 | 14.42 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 7.46 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 26.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M174 | R:R:N253 | 9.82 | 0 | No | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 8.14 | 1 | No | Yes | 5 | 6 | 2 | 2 | L:L:?1 | R:R:M177 | 6.09 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H250 | R:R:N181 | 3.83 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:F182 | R:R:V186 | 3.93 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:F182 | R:R:H250 | 26.02 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 6.92 | 1 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 17.04 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F242 | R:R:N280 | 9.67 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:S277 | R:R:W246 | 12.36 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N280 | R:R:W246 | 4.52 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 8.59 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:A273 | R:R:L249 | 4.73 | 0 | No | No | 6 | 5 | 2 | 1 | R:R:I274 | R:R:L249 | 4.28 | 1 | No | No | 4 | 5 | 1 | 1 | L:L:?1 | R:R:L249 | 11.93 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 6.23 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 10.36 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 2 | 1 | L:L:?1 | R:R:I274 | 16.15 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H278 | R:R:S277 | 4.18 | 1 | Yes | No | 6 | 7 | 2 | 2 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:A88 | R:R:W246 | 2.59 | 0 | No | Yes | 6 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 9.89 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 39.00 | Average Links Mediated by Hubs In Shell | 35.00 |
| ![](/psngpcr/ligands/U30/U30_8CIC_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/U30/U30_8CIC_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JWZ | A | Nucleotide | Adenosine | A2A | Homo Sapiens | AB928 | Na | - | 2.37 | 2023-08-16 | 10.1007/s11427-023-2459-8 |
![](/psngpcr/ligands/U30/U30_8JWZ_L_L_1.png)
A 2D representation of the interactions of U30 in 8JWZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I10 | R:R:Y9 | 3.63 | 0 | No | Yes | 6 | 5 | 2 | 1 | R:R:E13 | R:R:Y9 | 14.59 | 1 | Yes | Yes | 6 | 5 | 2 | 1 | R:R:I64 | R:R:Y9 | 3.63 | 1 | No | Yes | 6 | 5 | 2 | 1 | R:R:S67 | R:R:Y9 | 3.82 | 1 | No | Yes | 3 | 5 | 1 | 1 | R:R:Y271 | R:R:Y9 | 11.91 | 1 | No | Yes | 3 | 5 | 1 | 1 | L:L:?1 | R:R:Y9 | 4.42 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E13 | R:R:I64 | 5.47 | 1 | Yes | No | 6 | 6 | 2 | 2 | R:R:E13 | R:R:H278 | 13.54 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | L:L:?1 | R:R:A63 | 3.39 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:I66 | 5.38 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S67 | 5.66 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:C82 | R:R:L85 | 3.17 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:L85 | R:R:Y176 | 8.21 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:L85 | R:R:M177 | 4.24 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:L85 | R:R:N181 | 4.12 | 1 | Yes | No | 4 | 5 | 1 | 2 | L:L:?1 | R:R:L85 | 6.71 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T88 | R:R:W246 | 10.92 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:T88 | 4.76 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F168 | R:R:V172 | 14.42 | 1 | Yes | No | 4 | 3 | 1 | 2 | R:R:F168 | R:R:M177 | 6.22 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F168 | 26.24 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:M174 | R:R:M177 | 4.33 | 1 | Yes | Yes | 4 | 6 | 2 | 1 | R:R:M174 | R:R:N253 | 9.82 | 1 | Yes | No | 4 | 5 | 2 | 1 | R:R:M177 | R:R:Y176 | 3.59 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:N181 | R:R:Y176 | 5.81 | 1 | No | Yes | 5 | 6 | 2 | 2 | R:R:M177 | R:R:N253 | 4.21 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:M177 | 6.85 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:H250 | R:R:N181 | 3.83 | 0 | Yes | No | 6 | 5 | 1 | 2 | R:R:F182 | R:R:H250 | 24.89 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:H250 | R:R:V186 | 9.69 | 0 | Yes | No | 6 | 7 | 1 | 2 | R:R:F242 | R:R:W246 | 12.03 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:S277 | R:R:W246 | 12.36 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W246 | 11.04 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:I274 | R:R:L249 | 4.28 | 1 | No | No | 4 | 5 | 1 | 1 | L:L:?1 | R:R:L249 | 15.66 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:H250 | 6.23 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:N253 | 9.62 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y271 | 5.68 | 1 | Yes | No | 0 | 3 | 0 | 1 | R:R:H278 | R:R:I274 | 3.98 | 1 | Yes | No | 6 | 4 | 2 | 1 | L:L:?1 | R:R:I274 | 16.91 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H278 | R:R:S277 | 4.18 | 1 | Yes | No | 6 | 7 | 2 | 2 | R:R:A81 | R:R:F168 | 2.77 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:L267 | R:R:Y271 | 2.34 | 0 | No | No | 3 | 3 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 9.18 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/U30/U30_8JWZ_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/U30/U30_8JWZ_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|