Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.1875402
2A:A:V34 5.4075485
3A:A:L37 8.082519
4A:A:S44 4.165419
5A:A:K46 4.94429719
6A:A:I49 4.8125417
7A:A:F191 10.425485
8A:A:L194 6.295484
9A:A:F196 8.922587
10A:A:K197 7.945406
11A:A:F199 8.814515
12A:A:V201 4.362519
13A:A:S206 6.6325418
14A:A:E207 7.616519
15A:A:K210 6.57429719
16A:A:W211 5.835619
17A:A:I212 4.416518
18A:A:H213 6.705418
19A:A:C214 4.74417
20A:A:F215 8.11714719
21A:A:V218 3.6275419
22A:A:I221 5.584518
23A:A:F223 8.085419
24A:A:C224 3.665417
25A:A:S228 4.895409
26A:A:Y230 9.735148
27A:A:H244 5.9075404
28A:A:M247 6.8425416
29A:A:F250 7.524519
30A:A:I253 3.9618
31A:A:W258 6.995615
32A:A:F259 6.34419
33A:A:I264 3.585416
34A:A:I265 3.6725408
35A:A:L266 6.406519
36A:A:F267 5.635209
37A:A:L268 7.5025418
38A:A:F274 5.98509
39A:A:S281 5.41254147
40A:A:P282 5.08754145
41A:A:Y287 8.68417
42A:A:Y290 7.76407
43A:A:Q306 6.9925415
44A:A:F307 5.93518
45A:A:I319 5.795415
46A:A:Y320 6.163336137
47A:A:Q333 7.665485
48A:A:F336 6.23667688
49A:A:V342 2.91754137
50A:A:K345 7.10254135
51A:A:F354 12.38405
52G:G:R27 4.165438
53G:G:D48 6.644529
54G:G:P49 3.0325407
55G:G:L51 2.865406
56G:G:V54 3.955406
57G:G:P60 9.4154179
58G:G:F61 5.808577178
59R:R:T34 1.555405
60R:R:N40 6.1275409
61R:R:I47 4.7145107
62R:R:L53 5.9885108
63R:R:L64 5.0675479
64R:R:D68 6.2875479
65R:R:V75 7.235447
66R:R:M76 4.355407
67R:R:W88 5.874508
68R:R:W98 6.875405
69R:R:C108 6.404578
70R:R:H112 6.15667678
71R:R:Y121 7.564508
72R:R:W122 9.155154
73R:R:I128 4.8825487
74R:R:Y130 8.5556157
75R:R:R132 3.856584
76R:R:R134 6.3354157
77R:R:R138 7.5654155
78R:R:V146 4.7075477
79R:R:Y182 5.44237
80R:R:S186 4.1675407
81R:R:F191 9.15667648
82R:R:Y202 4.496509
83R:R:W304 7.155848
84R:R:L305 5.5025406
85R:R:F307 8.64447
86R:R:F308 10.39547
87R:R:V321 3.1275403
88R:R:W331 8.035646
89R:R:Y334 7.64333647
90R:R:N340 7.76579
91R:R:Y344 6.198579
92R:R:T345 6.38254107
93R:R:F351 7.688577108
94L:L:?1 9.3571040
95B:B:E10 4.64408
96B:B:L14 3.4025408
97B:B:I18 3.7475407
98B:B:R22 7.9475436
99B:B:V40 6.04523
100B:B:L51 6.866599
101B:B:H54 9.88599
102B:B:Y59 11.0917618
103B:B:M61 4.02406
104B:B:W63 7.448507
105B:B:V71 3.915408
106B:B:D76 5.7625499
107B:B:I80 10.205498
108B:B:I81 4.695457
109B:B:W82 11.5233699
110B:B:N88 6.295407
111B:B:K89 7.485699
112B:B:H91 5.835455
113B:B:I93 6.81457
114B:B:L95 5.108558
115B:B:W99 11.85619
116B:B:Y105 4.935406
117B:B:N110 6.90254164
118B:B:Y111 6.385164
119B:B:I120 5.7525456
120B:B:C121 5.0454128
121B:B:I123 4.1025166
122B:B:Y124 5.64556
123B:B:T128 4.174253
124B:B:E130 6.1754253
125B:B:V133 6.57454
126B:B:E138 6.5925456
127B:B:H142 8.3954129
128B:B:Y145 5.78718
129B:B:C149 5.08254128
130B:B:R150 6.945406
131B:B:F151 5.72167609
132B:B:L152 4.554263
133B:B:Q156 6.935405
134B:B:T159 6.4354129
135B:B:G162 3.8419
136B:B:L168 5.99466
137B:B:W169 12.555128
138B:B:D170 6.9875409
139B:B:Q176 7.534124
140B:B:F180 6.794567
141B:B:T181 3.15402
142B:B:H183 9.32167669
143B:B:D186 4.952519
144B:B:V187 4.685469
145B:B:M188 6.1175418
146B:B:V200 7.706536
147B:B:S201 4.6075469
148B:B:C204 5.4875417
149B:B:D205 5.508569
150B:B:K209 11.032566
151B:B:L210 6.216505
152B:B:W211 8.69333668
153B:B:R219 8.35754185
154B:B:Q220 8.685437
155B:B:F222 10.215438
156B:B:H225 9.56429739
157B:B:D228 6.55167619
158B:B:I232 4.696538
159B:B:F234 6.92535
160B:B:F235 7.64875826
161B:B:P236 6.03427
162B:B:N237 7.15525
163B:B:F241 7.52143736
164B:B:D246 6.205419
165B:B:D247 7.6025439
166B:B:T249 6.5325406
167B:B:R251 9.488538
168B:B:F253 6.70833636
169B:B:D254 4.4775409
170B:B:R256 7.3125219
171B:B:D258 9.78537
172B:B:M262 6.465404
173B:B:Y264 7.746525
174B:B:I269 3.31424
175B:B:F278 5.71714727
176B:B:R283 8.962529
177B:B:L284 4.4125425
178B:B:L285 7.045426
179B:B:Y289 7.25167627
180B:B:N295 5.79526
181B:B:W297 6.02528
182B:B:V307 3.9475423
183B:B:H311 7.956119
184B:B:R314 12.5825418
185B:B:L318 4.1025406
186B:B:V327 4.985406
187B:B:W332 12.9586719
188B:B:D333 5.85119
189B:B:F335 7.2675404
190B:B:L336 4.698507
191B:B:K337 9.0954116
192B:B:W339 8.553336119
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I19 B:B:K89 48.5118.72NoYes099
2A:A:I19 A:A:R15 48.39653.76NoNo095
3A:A:R15 B:B:H91 48.45365.64NoYes055
4A:A:D20 A:A:R24 33.16512.38NoNo063
5A:A:E28 A:A:R24 32.91891.16NoNo043
6A:A:E28 A:A:R32 32.84131.16NoNo044
7A:A:R32 R:R:R132 32.7674.26NoYes044
8B:B:H91 B:B:V133 24.68224.15YesYes554
9A:A:F196 A:A:L194 32.6989.74YesYes874
10A:A:L194 R:R:R132 32.22344.86YesYes844
11A:A:F196 A:A:V34 29.73179.18YesYes875
12A:A:T219 A:A:V34 29.85923.17NoYes075
13B:B:K89 B:B:W82 38.582812.76YesYes999
14B:B:L51 B:B:W82 24.720815.94YesYes999
15B:B:L70 B:B:W82 12.59926.83NoYes959
16B:B:L70 B:B:W63 12.54710.25NoYes057
17A:A:I212 A:A:I253 36.22782.94YesYes188
18A:A:I212 A:A:N256 19.1695.66YesNo088
19A:A:N256 A:A:W258 19.04814.52NoYes085
20A:A:I212 A:A:W211 66.26474.7YesYes189
21A:A:K46 A:A:L38 49.59738.46YesNo198
22A:A:L38 A:A:M198 49.4698.48NoNo087
23A:A:I222 A:A:M198 48.76722.92NoNo077
24A:A:G40 A:A:K46 52.98893.49NoYes199
25A:A:F223 A:A:G40 56.20383.01YesNo199
26A:A:F223 A:A:L249 77.38678.53YesNo199
27A:A:L249 A:A:R208 35.96737.29NoNo199
28A:A:I212 A:A:R208 36.03413.76YesNo189
29A:A:I253 A:A:L249 41.61234.28YesNo189
30B:B:G162 B:B:Y145 61.98314.35YesYes198
31A:A:W211 B:B:Y145 64.29553.86YesYes198
32A:A:T219 A:A:V342 29.73583.17NoYes077
33A:A:I222 A:A:I265 47.78034.42NoYes078
34A:A:F223 A:A:L266 25.25673.65YesYes199
35A:A:F307 A:A:L266 15.00634.87YesYes189
36A:A:F307 A:A:I303 10.41026.28YesNo087
37A:A:V342 A:A:Y320 29.47893.79YesYes1377
38A:A:A338 A:A:I265 46.29493.25NoYes068
39A:A:K345 A:A:Y320 73.8454.78YesYes1357
40A:A:F354 A:A:K345 73.72619.93YesYes055
41A:A:F354 A:A:L348 72.791912.18YesNo059
42A:A:L348 R:R:I124 70.44547.14NoNo098
43R:R:I124 R:R:I205 69.97425.89NoNo089
44R:R:I205 R:R:Y121 69.73833.63NoYes098
45R:R:W122 R:R:Y121 15.07024.82YesYes048
46R:R:W122 R:R:Y130 13.394417.36YesYes1547
47R:R:Y202 R:R:Y344 51.66512.98YesYes099
48R:R:A117 R:R:Y202 55.43424NoYes089
49R:R:A117 R:R:L201 55.68423.15NoNo085
50R:R:L201 R:R:Y121 55.27867.03NoYes058
51B:B:H91 B:B:I81 23.83286.63YesYes557
52B:B:I81 B:B:V71 23.91573.07YesYes078
53B:B:V112 B:B:V71 24.53113.21NoYes088
54B:B:V112 B:B:Y105 48.08863.79NoYes086
55B:B:H62 B:B:Y105 47.57744.36NoYes066
56B:B:H62 B:B:R150 47.490315.8NoYes066
57B:B:C148 B:B:R150 45.64525.57NoYes066
58B:B:C148 B:B:L190 1006.35NoNo065
59B:B:L190 B:B:S160 99.733910.51NoNo056
60B:B:S160 B:B:V187 99.20374.85NoYes069
61B:B:H183 B:B:V187 66.11415.54YesYes699
62B:B:H183 B:B:K209 32.515523.58YesYes696
63B:B:C218 B:B:K209 30.83174.85NoYes656
64B:B:C218 G:G:Q18 91.61447.63NoNo059
65G:G:M21 G:G:Q18 90.74164.08NoNo019
66B:B:M217 G:G:M21 89.86872.89NoNo031
67B:B:M217 B:B:R219 86.35224.96NoYes1835
68B:B:L210 B:B:R219 83.73116.07YesYes055
69B:B:L210 B:B:Q220 36.15465.32YesYes057
70B:B:D258 B:B:Q220 22.048318.27YesYes377
71B:B:D258 B:B:R22 18.57213.1YesYes376
72B:B:I18 B:B:R22 15.92747.52YesYes076
73B:B:I18 G:G:L19 11.50832.85YesNo079
74B:B:L126 B:B:V133 23.8482.98NoYes054
75B:B:L126 B:B:V112 23.73617.45NoNo058
76B:B:H183 B:B:W211 31.34927.41YesYes698
77B:B:C218 B:B:W211 61.65523.92NoYes658
78B:B:S201 B:B:V187 31.59323.23YesYes699
79B:B:S201 B:B:W211 31.31966.18YesYes698
80B:B:M325 G:G:P60 11.365710.06NoYes059
81B:B:M325 G:G:P49 22.3143.35NoYes057
82G:G:D48 G:G:P49 32.83293.22YesYes097
83G:G:D48 G:G:L51 35.25665.43YesYes096
84B:B:V40 G:G:L51 34.04352.98YesYes036
85B:B:R283 B:B:V40 30.56067.85YesYes293
86B:B:R283 G:G:C41 23.20845.57YesNo297
87B:B:F235 G:G:C41 22.87454.19YesNo267
88B:B:L30 B:B:T34 11.26822.95NoNo055
89B:B:L30 B:B:M262 10.56835.65NoYes054
90G:G:N59 G:G:V54 11.57965.91NoYes096
91G:G:F61 G:G:N59 11.6884.83YesNo1789
92B:B:I338 B:B:L51 23.48424.28NoYes059
93R:R:N340 R:R:Y344 44.74784.65YesYes799
94R:R:N336 R:R:N340 28.023112.26NoYes099
95R:R:N336 R:R:W304 25.657714.69NoYes098
96L:L:?1 R:R:W304 14.28033.97YesYes408
97R:R:D68 R:R:N340 11.06844.04YesYes799
98R:R:R134 R:R:Y130 11.961212.35YesYes1577
99R:R:P56 R:R:R134 11.39622.88NoYes067
100R:R:P56 R:R:Q55 11.1073.16NoNo067
101R:R:N58 R:R:Q55 10.81776.6NoNo097
102R:R:H112 R:R:L64 10.83496.43YesYes789
103B:B:L318 B:B:V327 10.06612.98YesYes066
104B:B:T321 B:B:W63 11.513212.13NoYes077
105B:B:D323 B:B:T321 11.26617.23NoNo2477
106B:B:D323 B:B:M325 11.16596.93NoNo075
107B:B:C148 B:B:T102 57.16965.07NoNo068
108B:B:L146 B:B:T102 57.32162.95NoNo078
109B:B:C121 B:B:L146 28.8653.17YesNo1287
110B:B:C149 B:B:L146 28.61824.76YesNo1287
111B:B:C121 B:B:T159 28.57993.38YesYes1289
112B:B:C149 B:B:T159 30.26443.38YesYes1289
113B:B:H142 B:B:T159 58.21736.85YesYes1299
114B:B:G162 B:B:S161 62.16653.71YesNo099
115B:B:H142 B:B:S161 62.110215.34YesNo099
116B:B:L210 B:B:V200 27.33564.47YesYes056
117B:B:L210 B:B:L255 18.516911.07YesNo056
118B:B:F241 B:B:V200 13.230314.42YesYes366
119B:B:F241 B:B:L255 13.22793.65YesNo366
120B:B:F241 B:B:F253 22.93478.57YesYes366
121B:B:F253 B:B:H225 15.88843.39YesYes369
122B:B:F222 B:B:Q220 12.34647.03YesYes387
123B:B:F222 B:B:F253 11.493113.93YesYes386
124B:B:F253 B:B:R251 10.59453.21YesYes368
125B:B:F235 B:B:F278 14.14748.57YesYes267
126B:B:F278 B:B:L285 11.687313.4YesYes276
127B:B:R314 B:B:T274 10.47286.47YesNo088
128B:B:S275 B:B:T274 10.32373.2NoNo088
129B:B:L318 B:B:S275 10.17996.01YesNo068
130A:A:D20 B:B:K89 32.45211.06NoYes969
131B:B:I338 G:G:F61 23.30148.79NoYes058
132G:G:P49 G:G:V54 11.2273.53YesYes076
133G:G:F61 G:G:P60 11.2815.78YesYes1789
134A:A:A338 A:A:Y320 46.08244NoYes067
135A:A:W258 B:B:R314 10.37494YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D102 R:R:V75 11.69 4 No Yes 8 7 1 2
R:R:V75 R:R:Y334 6.31 4 Yes Yes 7 7 2 1
R:R:S79 R:R:W331 6.18 4 No Yes 6 6 2 2
R:R:S79 R:R:Y334 5.09 4 No Yes 6 7 2 1
R:R:D102 R:R:Y334 10.34 4 No Yes 8 7 1 1
L:L:?1 R:R:D102 13.02 4 Yes No 0 8 0 1
R:R:M103 R:R:S154 7.67 0 No No 7 7 1 2
L:L:?1 R:R:M103 8.63 4 Yes No 0 7 0 1
R:R:C106 R:R:W304 5.22 4 No Yes 7 8 1 1
L:L:?1 R:R:C106 9.69 4 Yes No 0 7 0 1
R:R:I110 R:R:W304 5.87 0 No Yes 8 8 2 1
R:R:I153 R:R:S186 3.1 0 No Yes 6 7 2 1
R:R:E311 R:R:H177 12.31 0 No No 6 5 1 2
R:R:S186 R:R:Y182 3.82 0 Yes Yes 7 7 1 2
R:R:S186 R:R:T183 3.2 0 Yes No 7 6 1 2
L:L:?1 R:R:S186 6.55 4 Yes Yes 0 7 0 1
R:R:F308 R:R:T187 6.49 4 Yes No 7 7 1 2
L:L:?1 R:R:A190 4.12 4 Yes No 0 6 0 1
R:R:F191 R:R:F300 7.5 4 Yes No 8 9 2 2
R:R:F191 R:R:W304 4.01 4 Yes Yes 8 8 2 1
R:R:F191 R:R:F308 25.72 4 Yes Yes 8 7 2 1
R:R:F300 R:R:W304 7.02 4 No Yes 9 8 2 1
R:R:F308 R:R:W304 8.02 4 Yes Yes 7 8 1 1
R:R:G333 R:R:W304 8.44 0 No Yes 6 8 2 1
R:R:N336 R:R:W304 14.69 0 No Yes 9 8 2 1
L:L:?1 R:R:W304 3.97 4 Yes Yes 0 8 0 1
R:R:F307 R:R:F308 3.22 4 Yes Yes 7 7 1 1
R:R:F307 R:R:K310 8.69 4 Yes No 7 5 1 2
R:R:F307 R:R:T330 7.78 4 Yes No 7 4 1 2
L:L:?1 R:R:F307 14.87 4 Yes Yes 0 7 0 1
L:L:?1 R:R:F308 8.5 4 Yes Yes 0 7 0 1
L:L:?1 R:R:E311 15.02 4 Yes No 0 6 0 1
R:R:T330 R:R:Y334 6.24 0 No Yes 4 7 2 1
R:R:W331 R:R:Y334 8.68 4 Yes Yes 6 7 2 1
L:L:?1 R:R:Y334 9.2 4 Yes Yes 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
90.91Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
90.91Single8X64Desloratadine8X64-H1-Desloratadine
90.91Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
90.91Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
90.91Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
90.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
83.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
83.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
83.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
83.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
83.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
81.82Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
81.82Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
81.82Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
81.82Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
81.82Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
81.82Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
81.82Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
80.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
80.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
80.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
76.92Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
76.92Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
76.92Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
76.92Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
76.92Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
76.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
76.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
76.92Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
76.92Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
76.92Consensushistamine_offOrthosteric Ligandh1_off
75.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
75.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
75.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
75.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
75.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
75.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
75.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
75.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
75.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
75.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
75.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
75.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
75.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
75.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
75.00Single8GGNEpinephrine8GGN-β2-Epinephrine
75.00Single8GGOEpinephrine8GGO-β2-Epinephrine
75.00Single8GGUEpinephrine8GGU-β2-Epinephrine
75.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
75.00Single8JJOAlprenolol8JJO-β2-Alprenolol
75.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
75.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
75.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
75.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
75.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
75.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
75.00Consensustar_onOrthosteric Ligandta1_on
72.73Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
72.73Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
72.73Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
72.73Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
72.73Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
72.73Consensusalpha1_onOrthosteric Ligandalpha1a_on
72.73Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
71.43Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
71.43Single4AMIBucindolol4AMI-β1-Bucindolol
71.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
71.43Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
70.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
69.23Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
69.23Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
69.23Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
69.23Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
69.23Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
69.23Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
69.23Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
69.23Single7WC6LSD7WC6-5-HT2A-LSD
69.23Single7XKAEpinephrine7XKA-β2-Epinephrine
69.23Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
69.23Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
69.23Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
69.23Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
69.23Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
69.23Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
66.67Single3RZECidoxepin3RZE-H1-Cidoxepin
66.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
66.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
66.67Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
66.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
66.67Single6A94Zotepine6A94-5-HT2A-Zotepine
66.67Single6PS4ICI 118-5516PS4-β2-ICI 118-551
66.67Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
66.67Single6TPNHTL66416TPN-OX2-HTL6641
66.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
66.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
66.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
66.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
66.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
66.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
66.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
66.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
66.67Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GGIEpinephrine8GGI-β2-Epinephrine
66.67Single8GGKEpinephrine8GGK-β2-Epinephrine
66.67Single8GGLEpinephrine8GGL-β2-Epinephrine
66.67Single8GGMEpinephrine8GGM-β2-Epinephrine
66.67Single8GGPEpinephrine8GGP-β2-Epinephrine
66.67Single8GGQEpinephrine8GGQ-β2-Epinephrine
66.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
66.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
66.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
66.67Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
64.29Single2YDVNECA2YDV-A2A-NECA
64.29Single4U15Tiotropium4U15-M3-Tiotropium
64.29Single4UHRCGS216804UHR-A2A-CGS21680
64.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
64.29Single5G53NECA5G53-A2A-NECA-Gs
64.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
64.29Single6H7JIsoprenaline6H7J-β1-Isoprenaline
64.29Single6J21Aprepitant6J21-NK1-Aprepitant
64.29Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
64.29Single6OL9Tiotropium6OL9-M5-Tiotropium
64.29Single6TQ7SB-3348676TQ7-OX1-SB-334867
64.29Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
64.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
64.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
64.29Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.29Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
64.29Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
64.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
64.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
64.29Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
63.64Single3PBLEticlopride3PBL-D3-Eticlopride
63.64Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
63.64Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
63.64Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
63.64Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
63.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
63.64Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
63.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
62.50Single3NY9PubChem 9131033NY9-β2-PubChem 913103
62.50Single8X5YAstemizole8X5Y-H1-Astemizole
61.54Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
61.54Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
61.54Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
61.54Single4EJ4Naltrindole4EJ4-δ-Naltrindole
61.54Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
61.54Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
61.54Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
61.54Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
61.54Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
61.54Single6H7MSalbutamol6H7M-β1-Salbutamol
61.54Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
61.54Single6PS1Timolol6PS1-β2-Timolol
61.54Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
61.54Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
61.54Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7WC7Lisuride7WC7-5-HT2A-Lisuride
61.54Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
61.54Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
61.54Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
61.54Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8X63Mepyramine8X63-H1-Mepyramine
61.54Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
61.54Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
61.54Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
61.54Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
61.54Consensushistamine_onOrthosteric Ligandh1_on h4_on
61.54Consensustachykinin_offOrthosteric Ligandnk1_off
60.00Single4LDEBI1671074LDE-β2-BI167107
60.00Single5CXVTiotropium5CXV-M1-Tiotropium
60.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
60.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
60.00Single6HLPNetupitant6HLP-NK1-Netupitant
60.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
60.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
60.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
60.00Single7YITNalfurafine7YIT-κ-Nalfurafine
60.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
60.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8JJ8Formoterol8JJ8-β2-Formoterol
60.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
60.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
60.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
58.82Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
58.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
58.33Single6B73PubChem 1319551386B73-κ-PubChem 131955138
58.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
58.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
58.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
58.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
58.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
58.33Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGVEpinephrine8GGV-β2-Epinephrine
58.33Single8GGWEpinephrine8GGW-β2-Epinephrine
58.33Single8GGXEpinephrine8GGX-β2-Epinephrine
58.33Single8GH0Epinephrine8GH0-β2-Epinephrine
58.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
58.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single2Y03Isoprenaline2Y03-β1-Isoprenaline
57.14Single5C1MBU725C1M-μ-BU72
57.14Single5WIUNemonapride5WIU-D4-Nemonapride
57.14Single5WIVNemonapride5WIV-D4-Nemonapride-Na
57.14Single6E67BI1671076E67-β2-BI167107-Gs (fused)
57.14Single6PS6Timolol6PS6-β2-Timolol
57.14Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
57.14Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
57.14Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
57.14Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
57.14Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
57.14Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
57.14Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
57.14Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
57.14Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
57.14Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
57.14Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
56.25Single6H7LDobutamine6H7L-β1-Dobutamine
56.25Single6IBLArformoterol6IBL-β1-Arformoterol
56.25Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
56.25Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
56.25Consensusendothelin_offOrthosteric Ligandetb_off
56.25Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
54.55Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
53.85Single6TPGEMPA6TPG-OX2-EMPA
53.85Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
53.85Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
53.85Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
53.85Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
53.85Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGTEpinephrine8GGT-β2-Epinephrine
53.85Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
53.85Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.85Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
53.85Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
53.33Single3P0GBI1671073P0G-β2-BI167107
53.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
53.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
53.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
53.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
53.33Single5X93K-87945X93-ETB-K-8794
53.33Single6E59L-7607356E59-NK1-L-760735
53.33Single6J20Aprepitant6J20-NK1-Aprepitant
53.33Single6WGTLSD6WGT-5-HT2A-LSD
53.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
53.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
53.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
53.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
53.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
53.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
53.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
53.33Single8E0GBU728E0G-μ-BU72
53.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
53.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
53.33Consensus5ht5_offOrthosteric Ligand5ht5a_off
53.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
53.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
52.94Single4UG2CGS216804UG2-A2A-CGS21680
52.94Single6PT3DPI-2876PT3-δ-DPI-287
52.94Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
50.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
50.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
50.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
50.00Single2Y02Carmoterol2Y02-β1-Carmoterol
50.00Single2Y04Salbutamol2Y04-β1-Salbutamol
50.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
50.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
50.00Single4DAJTiotropium4DAJ-M3-Tiotropium
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
50.00Single4MQSIperoxo4MQS-M2-Iperoxo
50.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
50.00Single4U14Tiotropium4U14-M3-Tiotropium
50.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
50.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
50.00Single5DSGTiotropium5DSG-M4-Tiotropium
50.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
50.00Single6CM4Risperidone6CM4-D2-Risperidone
50.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
50.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
50.00Single6MXTSalmeterol6MXT-β2-Salmeterol
50.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
50.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7BU7BI1671077BU7-β1-BI167107
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
50.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
50.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
50.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGSEpinephrine8GGS-β2-Epinephrine
50.00Single8GGYEpinephrine8GGY-β2-Epinephrine
50.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
50.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
47.37Single6HLOAprepitant6HLO-NK1-Aprepitant
47.37Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
47.06Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.06Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
47.06Single7UM4AS26747237UM4-5-HT5A-AS2674723
47.06Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
47.06Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.06Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
47.06Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single5TVNLSD5TVN-5-HT2B-LSD
46.67Single5WQCEMPA5WQC-OX2-EMPA
46.67Single5XPRBosentan5XPR-ETB-Bosentan
46.67Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
46.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
46.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
46.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
46.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
46.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
46.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
46.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Single8EA0Iperoxo8EA0-M3-Iperoxo
46.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
46.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
46.67Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.15Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
46.15Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
46.15Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
46.15Single5DHHSB-6121115DHH-NOP-SB-612111
46.15Single6AKXA4R6AKX-CCR5-A4R
46.15Single6KUXRS-799486KUX-α2a-RS-79948
46.15Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
46.15Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
46.15Single6TODEMPA6TOD-OX1-EMPA-Na
46.15Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.15Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
46.15Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
46.15Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.15Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.15Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.15Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.15Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
46.15Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
46.15Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
46.15Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
46.15Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.15Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
46.15Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
45.45Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.45Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
45.45Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensussensory_onOrthosteric Ligandopsin_on
45.00Single6PT2KGCHM076PT2-δ-KGCHM07
44.44Single7SK9CCX6627SK9-ACKR3-CCX662
43.75Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
43.75Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
43.75Single4DJHJDTic4DJH-κ-JDTic
43.75Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
43.75Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
43.75Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
43.75Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
43.75Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
43.75Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
43.75Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
43.75Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
43.75Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
43.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
43.75Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
43.75Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
43.75Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
43.75Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
43.75Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
43.75Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
43.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
43.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.75Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
43.75Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
43.75Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
42.86Single2YDOAdenosine2YDO-A2A-Adenosine
42.86Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
42.86Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
42.86Single4MBSMaraviroc4MBS-CCR5-Maraviroc
42.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
42.86Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
42.86Single6IQLL7458706IQL-D4-L745870
42.86Single6VI4JDTic6VI4-κ-JDTic
42.86Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.86Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
42.86Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
42.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
42.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
42.86Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
42.86Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
42.86Consensussensory_offOrthosteric Ligandopsin_off
42.11Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
41.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
41.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
41.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
41.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
41.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
41.67Single8GGREpinephrine8GGR-β2-Epinephrine
41.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
41.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.18Single6A93Risperidone6A93-5-HT2A-Risperidone
41.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
41.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
41.18Single7DFPSpiperone7DFP-D2-Spiperone
41.18Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
41.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.18Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8JJLOlodaterol8JJL-β2-Olodaterol
41.18Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
40.91Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Single2Y01Dobutamine2Y01-β1-Dobutamine
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
40.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
40.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
40.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
40.00Single6TOTLemborexant6TOT-OX1-Lemborexant
40.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
40.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
40.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.00Single7UL4Alvimopan7UL4-μ-Alvimopan
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
40.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
40.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
40.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
40.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
40.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.89Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.89Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.89Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.89Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
38.89Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
38.89Single7EZCUKA7EZC-A2A-UKA
38.89Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
38.89Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.89Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
38.89Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
38.89Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
38.89Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
38.46Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
38.46Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
38.46Single6HLLCP999946HLL-NK1-CP99994
38.46Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
38.46Single6TP4ACT-4622066TP4-OX1-ACT-462206
38.46Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
38.46Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
38.46Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GH1Epinephrine8GH1-β2-Epinephrine
38.46Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
38.46Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
38.46Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
38.10Single5WF5UK-4320975WF5-A2A-UK-432097
38.10Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
37.50Single2Y00Dobutamine2Y00-β1-Dobutamine
37.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
37.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
37.50Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
37.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
37.50Single6TP6Filorexant6TP6-OX1-Filorexant
37.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
37.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
37.50Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
37.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
37.50Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
37.50Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
37.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
37.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Single5WF6UK-4320975WF6-A2A-UK-432097
36.84Single5ZTYAM102575ZTY-CB2-AM10257
36.84Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.84Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.36Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.71Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
35.71Single5WS3EMPA5WS3-OX2-EMPA
35.71Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single6ME2Ramelteon6ME2-MT1-Ramelteon
35.71Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.71Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
35.71Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
35.71Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
35.71Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
35.71Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8IWESpermidine8IWE-TAAR9-Spermidine
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensusgt_class-aOrthosteric Ligandgt_opsin
35.71Consensusgt_opsinOrthosteric Ligandgt_sensory
35.71Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.29Single7EPENAM5637EPE-mGlu-NAM563
35.29Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.29Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
35.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
35.29Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
35.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
35.29Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
35.29Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
33.33Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6TPKRetosiban6TPK-OT-Retosiban
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
33.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusgi_class-fOther Ligandgi_frizzled
33.33Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
33.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusvasopressin-ot_offOrthosteric Ligandot_off
32.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
31.82Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
31.82Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
31.58Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.58Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
31.58Single6K1QIRL25006K1Q-ETB-IRL2500
31.58Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
31.58Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
31.58Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusorexin_onOrthosteric Ligandox2_on
31.58Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.25Single6DRXLisuride6DRX-5-HT2B-Lisuride
31.25Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
31.25Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
31.25Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
31.25Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
31.25Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.25Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.25Single8CU6LJ-45178CU6-A2A-LJ-4517
31.25Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.25Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
31.25Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
31.25Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.25Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusblt_onOrthosteric Ligandblt1_on
31.25Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusleuko_onOrthosteric Ligandblt_on
30.77Single3UZAGTPL92363UZA-A2A-GTPL9236
30.77Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
30.77Single7WC5Psilocin7WC5-5-HT2A-Psilocin
30.77Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
30.77Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.77Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
30.77Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
30.77Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
30.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.00Single7XN9L-054,5227XN9-SST2-L-054,522
30.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
30.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
30.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
29.41Single5CGCHTL142425CGC-mGlu5-HTL14242
29.41Single5NM2ZM2413855NM2-A2A-ZM241385-Na
29.41Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
29.41Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
29.41Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
29.41Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8QOTNanobody E8QOT-μ-Nanobody E
29.17Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
28.57Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
28.57Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
28.57Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.57Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
28.57Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
27.78Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.78Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
27.78Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.78Single7B6WCyclazosin7B6W-α1b-Cyclazosin
27.78Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.78Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
27.78Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
27.78Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.78Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
27.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.78Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
27.78Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
27.78Consensuslpa_offOrthosteric Ligandlpa1_off
27.78Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.92Consensusendothelin_onOrthosteric Ligandetb_on eta_on
26.92Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
26.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
26.67Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
26.67Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single7F8ULintitript7F8U-CCKA-Lintitript
26.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.67Single7XRRLemborexant7XRR-OX2-Lemborexant
26.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
26.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
26.67Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
26.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.32Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
26.32Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.32Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
26.32Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
26.32Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
26.32Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single8WU1KCA8WU1-CB1-KCA-Arrestin1
26.32Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.32Consensusgs_steroidOrthosteric Ligandgs_bileacid
26.32Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.09Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.93Single6IGLIRL16206IGL-ETB-IRL1620
25.93Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
25.93Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single5CGDHTL142425CGD-mGlu5-HTL14242
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5JTBZM2413855JTB-A2A-ZM241385
25.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
25.00Single5UVIZM2413855UVI-A2A-ZM241385
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
25.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6V9SGTPL114036V9S-OX1-GTPL11403
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7T32ZM2413857T32-A2A-ZM241385
25.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
25.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
25.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
25.00Consensussteroid_onOrthosteric Ligandbileacid_on
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
24.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
23.81Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
23.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
23.81Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
23.81Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.53Single3EMLZM2413853EML-A2A-ZM241385
23.53Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.53Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.53Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.53Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.53Single5TGZAM65385TGZ-CB1-AM6538
23.53Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
23.53Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.53Single6FFHFenobam6FFH-mGlu5-Fenobam
23.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
23.53Single6S0LZM2413856S0L-A2A-ZM241385
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
23.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
23.53Single7PYRPSB-21157PYR-A2A-PSB-2115
23.53Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.53Consensusa2_offOrthosteric Liganda2a_off
23.53Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.53Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.53Consensuscck_offOrthosteric Ligandccka_off
23.53Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
23.53Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.53Consensusgi_hcarOrthosteric Ligandgi_hca
23.53Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
23.08Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.08Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.08Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
23.08Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.73Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.73Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7F8XNN90567F8X-CCKA-NN9056
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
22.73Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
22.73Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
22.73Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Consensusclass-d_offOrthosteric Ligandste2_off
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.22Single4NTJAZD12834NTJ-P2Y12-AZD1283
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single6S0QZM2413856S0Q-A2A-ZM241385
22.22Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
22.22Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
22.22Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.22Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.22Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.22Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
21.74Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
21.74Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
21.74Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.74Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
21.43Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
21.43Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
21.43Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.43Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.43Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.43Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.43Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.43Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
21.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
21.05Single5XR8AM8415XR8-CB1-AM841
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
21.05Single7P2L4YI7P2L-mGlu5-4YI
21.05Single7PX4PSB-21137PX4-A2A-PSB-2113
21.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
21.05Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.05Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.05Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.05Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
21.05Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
21.05Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.05Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.05Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.83Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
20.83Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
20.83Consensusangiotensin_onOrthosteric Ligandat1_on
20.83Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.83Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.69Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.69Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
20.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
20.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
20.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
20.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
20.00Consensusclass-d_onOrthosteric Ligandste2_on
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
20.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
20.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
19.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.23Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
19.23Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
19.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
19.05Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
19.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
19.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.75Single5K2DZM2413855K2D-A2A-ZM241385
18.75Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
18.75Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.75Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
18.75Single6JZHZM2413856JZH-A2A-ZM241385-Na
18.75Single6PS7ZM2413856PS7-A2A-ZM241385-Na
18.75Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.75Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
18.75Single8GNGIstradefylline8GNG-A2A-Istradefylline
18.75Single8IHKAcifran8IHK-HCA3-Acifran
18.75Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.75Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.75Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
18.18Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusgo_class-b1Orthosteric Ligandgo_crf
17.86Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.65Single3REYPubChem 56973REY-A2A-PubChem 5697
17.65Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.65Single5IU4ZM2413855IU4-A2A-ZM241385-Na
17.65Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.65Single5K2CZM2413855K2C-A2A-ZM241385-Na
17.65Single5NLXZM2413855NLX-A2A-ZM241385-Na
17.65Single5NM4ZM2413855NM4-A2A-ZM241385-Na
17.65Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
17.65Single6MH8ZM2413856MH8-A2A-ZM241385
17.65Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
17.65Single7AROLUF58337ARO-A2A-LUF5833-Na
17.65Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.65Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
17.65Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.65Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
17.65Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
17.65Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
17.65Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
17.65Single8K5CAcipimox8K5C-HCA2-Acipimox
17.65Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.65Consensusgnrh_offOrthosteric Ligandgnrh1_off
17.65Consensushca_onOrthosteric Ligandhca2_on hca3_on
17.65Consensushcar_onOrthosteric Ligandhca_on
17.65Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
17.65Consensuss1p_offOrthosteric Ligands1p1_off
17.39Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.39Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.39Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
17.39Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.24Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.24Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
16.67Single4YAYZD-71554YAY-AT1-ZD-7155
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single5UENDU1725UEN-A1-DU172
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.67Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
16.67Single6LPJZM2413856LPJ-A2A-ZM241385-Na
16.67Single6LPKZM2413856LPK-A2A-ZM241385-Na
16.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.67Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
16.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.67Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
16.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8K5DGSK2560738K5D-HCA2-GSK256073
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
16.67Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
16.67Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
16.13Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.00Single6W25SHU91196W25-MC4-SHU9119-Ca
16.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
15.79Single6D26Fevipiprant6D26-DP2-Fevipiprant
15.79Single6GPXMK08126GPX-CCR2-MK0812
15.79Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.79Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
15.79Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.79Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.79Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.79Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.79Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8PWNTheophylline8PWN-A2A-Theophylline
15.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
15.38Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.38Consensusclass-c_onOther Ligandgabab_on mglu_on
15.15Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
15.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
15.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
15.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
15.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.81Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.81Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
14.81Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.81Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
14.81Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.29Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
14.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
14.29Single8A2OTheophylline8A2O-A2A-Theophylline-Na
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
14.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.29Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.29Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
14.29Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.29Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
14.29Consensusdp_offOrthosteric Liganddp2_off
14.29Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.29Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
14.29Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.29Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.79Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.79Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.64Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.64Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
13.64Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.64Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.64Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.64Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.64Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
13.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
13.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.33Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
13.33Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.33Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single5EE7MK08935EE7-Glucagon-MK0893
13.04Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.04Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
13.04Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.04Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.04Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.04Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
13.04Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
13.04Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.04Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.04Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.90Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.82Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
12.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.50Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.50Consensusclass-t_onOrthosteric Ligandtaste2_on
12.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
12.50Consensusgs_class-tOrthosteric Ligandgs_taste
12.50Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.50Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.12Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
11.76Single3PWHZM2413853PWH-A2A-ZM241385
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.76Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.76Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
11.76Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.54Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.54Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.54Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
11.43Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.43Consensuspth_onOrthosteric Ligandpth1_on pth2_on
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.11Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.11Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
11.11Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
11.11Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.11Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.81Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
10.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.71Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.71Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
10.71Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.71Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single6D27CAY104716D27-DP2-CAY10471
10.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.53Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensushcar_offOrthosteric Ligandsuccinate_off
10.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
10.53Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.53Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.34Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
10.34Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.00Consensusclass-c_offOther Ligandgabab_off mglu_off
10.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.00Consensusep_offOrthosteric Ligandep4_off
10.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
10.00Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.68Single6LMLGlucagon6LML-Glucagon-Glucagon
9.68Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
9.68Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.68Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
9.52Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.52Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.52Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
9.52Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.52Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.52Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.52Consensuschemerin_onOrthosteric Ligandcml1_on
9.52Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Consensusrelaxin_onOrthosteric Ligandrxfp4_on
9.52Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.38Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
9.09Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
9.09Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
9.09Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
9.09Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.09Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
9.09Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
9.09Consensusglp_onOrthosteric Ligandglp1_on glp2_on
8.82Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.82Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.82Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.70Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
8.70Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
8.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
8.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
8.33Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.33Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
8.00Single4XT1Fractalkine4XT1-US28-Fractalkine
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
7.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
7.69Consensussst_offOrthosteric Ligandsst2_off
7.50Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.41Single3OE0CVX153OE0-CXCR4-CVX15
7.41Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
7.41Single7XNACYN1548067XNA-SST2-CYN154806
7.41Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.14Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.14Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
7.14Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.14Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.14Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
6.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
6.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
6.90Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.90Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
6.90Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.67Single4XT3Fractalkine4XT3-US28-Fractalkine
6.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.67Single6FJ3PTH6FJ3-PTH1-PTH
6.67Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.67Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
6.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
6.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
6.67Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.67Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.67Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.67Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.45Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
6.45Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
6.45Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
6.45Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.45Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.45Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.25Single3OE6IT1t3OE6-CXCR4-IT1t
6.25Single3OE8IT1t3OE8-CXCR4-IT1t
6.25Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.25Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.25Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.25Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.25Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.25Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.25Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.25Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.88Single3OE9IT1t3OE9-CXCR4-IT1t
5.88Single5L7IVismodegib5L7I-SMO-Vismodegib
5.88Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.88Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.88Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.71Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.71Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single3ODUIT1t3ODU-CXCR4-IT1t
5.56Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.56Single5U09Taranabant5U09-CB1-Taranabant
5.56Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.56Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.56Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.56Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.56Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.56Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.41Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.26Single6ZINSR486926ZIN-NTS1-SR48692
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7VV6C48/807VV6-MRGPRX2-C48/80
5.26Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8K2WAMG4878K2W-CXCR3-AMG487
5.26Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.26Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
5.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
5.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.76Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single6Z4SSR486926Z4S-NTS1-SR48692
4.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.76Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.55Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.55Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.55Single5V56TC1145V56-SMO-TC114
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.55Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.55Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.55Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.35Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.35Single4XESNeurotensin4XES-NTS1-Neurotensin
4.35Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
4.35Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.35Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.35Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Consensusnts_offOrthosteric Ligandnts1_off
4.35Consensusnts_onOrthosteric Ligandnts1_on
4.17Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.17Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
4.17Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.17Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.17Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.17Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
3.85Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.85Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.70Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.70Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.70Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single7SK5CXCL127SK5-ACKR3-CXCL12
3.70Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
3.57Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
3.57Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.45Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.23Single7SK3CXCL127SK3-ACKR3-CXCL12
3.23Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.23Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.12Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.12Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.03Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.03Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.03Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.03Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.94Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.94Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.94Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
2.94Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.86Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.78Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.78Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.70Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.70Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.38Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.38Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7E33
Class A
SubFamily Amine
Type 5-Hydroxytryptamine
SubType 5-HT1E
Species Homo sapiens
Ligand BRL-54443
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.9
Date 2021-04-14
D.O.I. 10.1038/s41586-021-03376-8
Net Summary
Imin 2.92
Number of Linked Nodes 821
Number of Links 1050
Number of Hubs 192
Number of Links mediated by Hubs 696
Number of Communities 26
Number of Nodes involved in Communities 282
Number of Links involved in Communities 427
Path Summary
Number Of Nodes in MetaPath 136
Number Of Links MetaPath 135
Number of Shortest Paths 2141231
Length Of Smallest Path 3
Average Path Length 35.2958
Length of Longest Path 63
Minimum Path Strength 1.16
Average Path Strength 6.10554
Maximum Path Strength 23.76
Minimum Path Correlation 0.7
Average Path Correlation 0.982215
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 36.6459
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.9624
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeHVU
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeHVU
Name3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
Synonyms
Identifier3-(1-methylpiperidin-4-yl)-1~{H}-indol-5-ol
FormulaC14 H18 N2 O
Molecular Weight230.306
SMILESCN1CCC(CC1)c2c[nH]c3c2cc(cc3)O
PubChem2438
Formal Charge0
Total Atoms35
Total Chiral Atoms0
Total Bonds37
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7E33_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKTGI VETHFTFKD LHFKMFDVG AQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVNRMHA SMKLFDSIC NNKWFTDTS IILFLNKKD 
LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE DLNKRKDTK 
EIYTHFTCS TDTKNVQFV FDAVTDVII KNNLKDCGL F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7E33_Chain_G
RKLVEQLKM EANIDRIKV SKAAADLMA YCEAHAKED PLLTPVPAS 
ENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP28566
Sequence
>7E33_Chain_R
TEKMLICMT LVVITTLTT LLNLAVIMA IGTTKKLHQ PANYLICSL 
AVTDLLVAV LVMPLSIIY IVMDRWKLG YFLCEVWLS VDMTCCTCS 
IWHLCVIAL DRYWAITNA IEYARKRTA KRAALMILT VWTISIFIS 
MPPLQCTIQ HDHVIYTIY STLGAFYIP LTLILILYY RIYHAAKSL 
SSTRERKAA RILGLILGA FILSWLPFF IKELIVGLS IYTVSSEVA 
DFLTWLGYV NSLINPLLY TSFNEDFKL AFKKL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7E33_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
5ht1e_on7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
gi_5ht7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI




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