psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M23	R:R:M27	4.33	No	No	0	5	4
2	R:R:I25	R:R:T28	3.04	No	No	0	4	5
3	R:R:I80	R:R:L29	5.71	No	No	1	6	6
4	R:R:L29	R:R:W331	21.64	No	Yes	1	6	6
5	R:R:M76	R:R:T33	9.03	Yes	No	0	7	6
6	R:R:L35	R:R:L39	8.3	No	No	0	4	8
7	R:R:L338	R:R:L35	6.92	No	No	0	6	4
8	R:R:N40	R:R:T36	4.39	Yes	No	0	9	8
9	R:R:L338	R:R:T36	10.32	No	No	0	6	8
10	R:R:L69	R:R:T37	4.42	No	No	5	7	6
11	R:R:T37	R:R:V73	3.17	No	No	5	6	4
12	R:R:D68	R:R:N40	6.73	Yes	Yes	0	9	9
13	R:R:L69	R:R:N40	6.87	No	Yes	0	7	9
14	R:R:N40	R:R:P341	6.52	Yes	No	0	9	9
15	R:R:L41	R:R:M45	4.24	No	No	0	5	4
16	R:R:I47	R:R:V43	3.07	Yes	No	0	7	9
17	R:R:A65	R:R:V43	3.39	No	No	0	9	9
18	R:R:T345	R:R:V43	3.17	Yes	No	0	7	9
19	R:R:C62	R:R:I44	3.27	No	No	0	6	7
20	R:R:I44	R:R:V66	3.07	No	No	0	7	6
21	R:R:L358	R:R:M45	4.24	No	No	0	6	4
22	R:R:I47	R:R:L53	4.28	Yes	Yes	3	7	8
23	R:R:C62	R:R:I47	8.18	No	Yes	0	6	7
24	R:R:F351	R:R:I47	6.28	Yes	Yes	3	8	7
25	R:R:L53	R:R:T50	5.9	Yes	No	3	8	7
26	R:R:A354	R:R:T50	3.36	No	No	3	8	7
27	R:R:H54	R:R:K51	3.93	No	No	0	8	7
28	R:R:D350	R:R:K52	11.06	No	No	0	7	6
29	R:R:L53	R:R:N58	6.87	Yes	No	3	8	9
30	R:R:F351	R:R:L53	9.74	Yes	Yes	3	8	8
31	R:R:A354	R:R:L53	3.15	No	Yes	3	8	8
32	R:R:H54	R:R:Y59	4.36	No	No	0	8	5
33	R:R:P56	R:R:Q55	3.16	No	No	0	6	7
34	R:R:N58	R:R:Q55	6.6	No	No	0	9	7
35	R:R:A57	R:R:R134	4.15	No	Yes	0	8	7
36	R:R:F351	R:R:N58	4.83	Yes	No	3	8	9
37	R:R:D119	R:R:L60	4.07	No	No	0	9	8
38	R:R:A139	R:R:L60	3.15	No	No	0	7	8
39	R:R:L60	R:R:M142	4.24	No	No	0	8	7
40	R:R:F351	R:R:I61	5.02	Yes	No	0	8	8
41	R:R:H112	R:R:S63	9.76	Yes	No	2	8	9
42	R:R:I143	R:R:S63	10.84	No	No	2	7	9
43	R:R:D68	R:R:L64	4.07	Yes	Yes	2	9	9
44	R:R:H112	R:R:L64	6.43	Yes	Yes	2	8	9
45	R:R:I116	R:R:L64	4.28	No	Yes	2	9	9
46	R:R:L64	R:R:N340	5.49	Yes	Yes	2	9	9
47	R:R:C108	R:R:T67	5.07	Yes	No	2	8	8
48	R:R:H112	R:R:T67	4.11	Yes	No	2	8	8
49	R:R:D68	R:R:S337	10.31	Yes	No	0	9	9
50	R:R:D68	R:R:N340	4.04	Yes	Yes	2	9	9
51	R:R:L69	R:R:V73	2.98	No	No	5	7	4
52	R:R:V71	R:R:V75	4.81	No	Yes	0	8	7
53	R:R:C105	R:R:V71	5.12	No	No	0	6	8
54	R:R:S337	R:R:V71	3.23	No	No	0	9	8
55	R:R:A72	R:R:M76	3.22	No	Yes	0	7	7
56	R:R:L74	R:R:V73	2.98	No	No	0	5	4
57	R:R:V75	R:R:W98	6.13	Yes	Yes	0	7	5
58	R:R:D102	R:R:V75	11.69	No	Yes	1	8	7
59	R:R:V75	R:R:Y334	6.31	Yes	Yes	1	7	7
60	R:R:M76	R:R:W331	3.49	Yes	Yes	0	7	6
61	R:R:L78	R:R:W98	10.25	No	Yes	0	5	5
62	R:R:S79	R:R:W331	6.18	No	Yes	1	6	6
63	R:R:S79	R:R:Y334	5.09	No	Yes	1	6	7
64	R:R:I80	R:R:W331	4.7	No	Yes	1	6	6
65	R:R:W88	R:R:Y82	4.82	Yes	No	0	8	5
66	R:R:Q172	R:R:Y82	4.51	No	No	0	4	5
67	R:R:T174	R:R:Y82	3.75	No	No	0	3	5
68	R:R:D327	R:R:I83	5.6	No	No	0	5	5
69	R:R:I83	R:R:W331	3.52	No	Yes	0	5	6
70	R:R:K89	R:R:R87	22.28	No	No	0	4	3
71	R:R:Q172	R:R:R87	3.5	No	No	0	4	3
72	R:R:L90	R:R:W88	9.11	No	Yes	0	6	8
73	R:R:C95	R:R:W88	6.53	No	Yes	0	9	8
74	R:R:W88	R:R:W98	6.56	Yes	Yes	0	8	5
75	R:R:L90	R:R:L94	8.3	No	No	0	6	4
76	R:R:F93	R:R:V97	6.55	No	No	0	3	4
77	R:R:C95	R:R:L99	3.17	No	No	0	9	5
78	R:R:C173	R:R:C95	7.28	No	No	0	9	9
79	R:R:L99	R:R:W98	4.56	No	Yes	0	5	5
80	R:R:L158	R:R:S100	7.51	No	No	0	6	6
81	R:R:D102	R:R:Y334	10.34	No	Yes	1	8	7
82	L:L:?1	R:R:D102	13.02	Yes	No	1	0	8
83	R:R:M103	R:R:S154	7.67	No	No	0	7	7
84	L:L:?1	R:R:M103	8.63	Yes	No	0	0	7
85	R:R:S150	R:R:T104	6.4	No	No	0	8	6
86	R:R:S154	R:R:T104	7.99	No	No	0	7	6
87	R:R:C106	R:R:W304	5.22	No	Yes	1	7	8
88	L:L:?1	R:R:C106	9.69	Yes	No	1	0	7
89	R:R:S150	R:R:T107	6.4	No	No	0	8	7
90	R:R:I153	R:R:T107	4.56	No	No	0	6	7
91	R:R:C108	R:R:H112	4.42	Yes	Yes	2	8	8
92	R:R:C108	R:R:V146	3.42	Yes	Yes	2	8	7
93	R:R:C108	R:R:W147	15.67	Yes	No	0	8	9
94	R:R:C108	R:R:S150	3.44	Yes	No	0	8	8
95	R:R:I110	R:R:P194	3.39	No	No	0	8	9
96	R:R:I110	R:R:W304	5.87	No	Yes	0	8	8
97	R:R:C114	R:R:W111	3.92	No	No	0	7	5
98	R:R:V146	R:R:W111	3.68	Yes	No	0	7	5
99	R:R:I149	R:R:W111	10.57	No	No	0	5	5
100	R:R:H112	R:R:I143	5.3	Yes	No	2	8	7
101	R:R:H112	R:R:V146	6.92	Yes	Yes	2	8	7
102	R:R:L113	R:R:N340	12.36	No	Yes	2	8	9
103	R:R:L113	R:R:Y344	7.03	No	Yes	2	8	9
104	R:R:C114	R:R:P194	3.77	No	No	0	7	9
105	R:R:C114	R:R:L197	4.76	No	No	0	7	6
106	R:R:V115	R:R:V146	4.81	No	Yes	0	7	7
107	R:R:I116	R:R:R120	5.01	No	No	2	9	9
108	R:R:I116	R:R:Y344	6.04	No	Yes	2	9	9
109	R:R:A117	R:R:L201	3.15	No	No	0	8	5
110	R:R:A117	R:R:Y202	4	No	Yes	0	8	9
111	R:R:L118	R:R:W122	17.08	No	Yes	0	5	4
112	R:R:L118	R:R:L201	6.92	No	No	0	5	5
113	R:R:D119	R:R:Y130	9.2	No	Yes	4	9	7
114	R:R:D119	R:R:R134	5.96	No	Yes	4	9	7
115	R:R:R120	R:R:Y344	10.29	No	Yes	2	9	9
116	R:R:W122	R:R:Y121	4.82	Yes	Yes	0	4	8
117	R:R:T125	R:R:Y121	9.99	No	Yes	0	7	8
118	R:R:L201	R:R:Y121	7.03	No	Yes	0	5	8
119	R:R:R204	R:R:Y121	12.35	No	Yes	0	6	8
120	R:R:I205	R:R:Y121	3.63	No	Yes	0	9	8
121	R:R:W122	R:R:Y130	17.36	Yes	Yes	4	4	7
122	R:R:R138	R:R:W122	3	Yes	Yes	4	5	4
123	R:R:M142	R:R:W122	3.49	No	Yes	0	7	4
124	R:R:I124	R:R:I205	5.89	No	No	0	8	9
125	R:R:E129	R:R:N126	6.57	No	No	0	5	6
126	R:R:I128	R:R:R132	5.01	No	No	0	7	4
127	R:R:K133	R:R:Y130	3.58	No	Yes	4	5	7
128	R:R:R134	R:R:Y130	12.35	Yes	Yes	4	7	7
129	R:R:R138	R:R:Y130	6.17	Yes	Yes	4	5	7
130	R:R:K133	R:R:R138	19.8	No	Yes	4	5	5
131	R:R:I149	R:R:T145	3.04	No	No	0	5	1
132	R:R:F152	R:R:T148	5.19	No	No	0	4	4
133	R:R:I153	R:R:S186	3.1	No	Yes	0	6	7
134	R:R:M155	R:R:P156	5.03	No	No	0	5	6
135	R:R:P156	R:R:P157	5.84	No	No	6	6	7
136	R:R:P156	R:R:Y182	6.95	No	Yes	6	6	7
137	R:R:P157	R:R:Y182	9.74	No	Yes	6	7	7
138	R:R:E311	R:R:H177	12.31	No	No	0	6	5
139	R:R:H177	R:R:V314	6.92	No	No	0	5	2
140	R:R:G315	R:R:H177	4.77	No	No	0	5	5
141	R:R:D178	R:R:H179	18.91	No	No	0	6	6
142	R:R:S186	R:R:Y182	3.82	Yes	Yes	0	7	7
143	R:R:S186	R:R:T183	3.2	Yes	No	0	7	6
144	R:R:I184	R:R:L316	4.28	No	No	0	5	3
145	L:L:?1	R:R:S186	6.55	Yes	Yes	0	0	7
146	R:R:T187	R:R:Y192	6.24	No	No	1	7	5
147	R:R:F308	R:R:T187	6.49	Yes	No	1	7	7
148	R:R:L312	R:R:T187	4.42	No	No	1	5	7
149	R:R:G189	R:R:I193	3.53	No	No	0	4	6
150	L:L:?1	R:R:A190	4.12	Yes	No	0	0	6
151	R:R:F191	R:R:Y192	3.09	Yes	No	1	8	5
152	R:R:F191	R:R:L195	7.31	Yes	No	1	8	6
153	R:R:F191	R:R:F300	7.5	Yes	No	1	8	9
154	R:R:F191	R:R:W304	4.01	Yes	Yes	1	8	8
155	R:R:F191	R:R:L305	7.31	Yes	Yes	0	8	6
156	R:R:F191	R:R:F308	25.72	Yes	Yes	1	8	7
157	R:R:L312	R:R:Y192	5.86	No	No	1	5	5
158	R:R:I193	R:R:P194	6.77	No	No	0	6	9
159	R:R:L195	R:R:L199	5.54	No	No	0	6	5
160	R:R:F300	R:R:L195	3.65	No	No	1	9	6
161	R:R:I200	R:R:T196	3.04	No	No	0	5	3
162	R:R:I198	R:R:Y202	3.63	No	Yes	0	8	9
163	R:R:I200	R:R:R204	6.26	No	No	0	5	6
164	R:R:I296	R:R:Y202	4.84	No	Yes	0	8	9
165	R:R:L297	R:R:Y202	7.03	No	Yes	0	7	9
166	R:R:Y202	R:R:Y344	2.98	Yes	Yes	0	9	9
167	R:R:E286	R:R:Y206	7.86	No	No	0	8	5
168	R:R:A290	R:R:Y206	5.34	No	No	0	7	5
169	R:R:L293	R:R:Y206	3.52	No	No	0	8	5
170	R:R:H207	R:R:K210	6.55	No	No	0	5	5
171	R:R:S282	R:R:T284	3.2	No	No	0	5	4
172	R:R:R287	R:R:R291	9.6	No	No	0	5	8
173	R:R:K288	R:R:R291	4.95	No	No	0	8	8
174	R:R:I292	R:R:K288	7.27	No	No	0	8	8
175	R:R:F347	R:R:I292	11.3	No	No	0	7	8
176	R:R:L295	R:R:L343	4.15	No	No	0	8	8
177	R:R:I296	R:R:L343	4.28	No	No	0	8	8
178	R:R:F300	R:R:W304	7.02	No	Yes	1	9	8
179	R:R:I301	R:R:L305	4.28	No	Yes	0	6	6
180	R:R:N336	R:R:S303	7.45	No	No	0	9	7
181	R:R:F308	R:R:W304	8.02	Yes	Yes	1	7	8
182	R:R:G333	R:R:W304	8.44	No	Yes	0	6	8
183	R:R:N336	R:R:W304	14.69	No	Yes	0	9	8
184	L:L:?1	R:R:W304	3.97	Yes	Yes	1	0	8
185	R:R:L305	R:R:P306	3.28	Yes	No	0	6	9
186	R:R:I309	R:R:L305	7.14	No	Yes	0	7	6
187	R:R:L329	R:R:P306	3.28	No	No	0	4	9
188	R:R:F307	R:R:F308	3.22	Yes	Yes	1	7	7
189	R:R:F307	R:R:K310	8.69	Yes	No	0	7	5
190	R:R:F307	R:R:T330	7.78	Yes	No	0	7	4
191	L:L:?1	R:R:F307	14.87	Yes	Yes	1	0	7
192	L:L:?1	R:R:F308	8.5	Yes	Yes	1	0	7
193	R:R:K310	R:R:V321	4.55	No	Yes	0	5	3
194	R:R:A326	R:R:K310	3.21	No	No	0	4	5
195	L:L:?1	R:R:E311	15.02	Yes	No	0	0	6
196	R:R:V314	R:R:V321	3.21	No	Yes	0	2	3
197	R:R:I318	R:R:L316	5.71	No	No	0	5	3
198	R:R:V321	R:R:V325	3.21	Yes	No	0	3	4
199	R:R:S322	R:R:V325	4.85	No	No	0	5	4
200	R:R:F328	R:R:L329	4.87	No	No	0	4	4
201	R:R:T330	R:R:Y334	6.24	No	Yes	0	4	7
202	R:R:W331	R:R:Y334	8.68	Yes	Yes	1	6	7
203	L:L:?1	R:R:Y334	9.2	Yes	Yes	1	0	7
204	R:R:N336	R:R:N340	12.26	No	Yes	0	9	9
205	R:R:I339	R:R:L343	4.28	No	No	0	6	8
206	R:R:N340	R:R:Y344	4.65	Yes	Yes	2	9	9
207	R:R:L342	R:R:S346	3	No	No	0	7	5
208	R:R:F351	R:R:T345	14.27	Yes	Yes	3	8	7
209	R:R:F355	R:R:T345	6.49	No	Yes	3	7	7
210	R:R:E349	R:R:N348	7.89	No	No	3	5	9
211	R:R:D350	R:R:N348	12.12	No	No	3	7	9
212	R:R:F351	R:R:N348	7.25	Yes	No	3	8	9
213	R:R:D350	R:R:E349	9.09	No	No	3	7	5
214	R:R:F351	R:R:F355	6.43	Yes	No	3	8	7
215	R:R:L24	R:R:T20	2.95	No	No	0	5	2
216	R:R:L29	R:R:T28	2.95	No	No	0	6	5
217	R:R:D327	R:R:S323	2.94	No	No	0	5	1
218	R:R:P56	R:R:R134	2.88	No	Yes	0	6	7
219	R:R:I175	R:R:L99	2.85	No	No	0	5	5
220	R:R:I184	R:R:L188	2.85	No	No	0	5	5
221	R:R:A46	R:R:F355	2.77	No	No	0	8	7
222	R:R:L70	R:R:L74	2.77	No	No	0	7	5
223	R:R:A131	R:R:R132	2.77	No	No	0	5	4
224	R:R:E129	R:R:I128	2.73	No	No	0	5	7
225	R:R:A136	R:R:Y59	2.67	No	No	0	2	5
226	R:R:A139	R:R:Y59	2.67	No	No	0	7	5
227	R:R:A123	R:R:Y130	2.67	No	Yes	0	8	7
228	R:R:E96	R:R:L158	2.65	No	No	0	6	6
229	R:R:T320	R:R:Y319	2.5	No	No	0	3	7
230	R:R:F152	R:R:M155	2.49	No	No	0	4	5
231	R:R:I81	R:R:W88	2.35	No	Yes	0	5	8
232	R:R:L293	R:R:Y202	2.34	No	Yes	0	8	9
233	R:R:G48	R:R:I47	1.76	No	Yes	0	3	7
234	R:R:C26	R:R:V30	1.71	No	No	0	4	3
235	R:R:G91	R:R:L94	1.71	No	No	0	7	4
236	R:R:C105	R:R:V101	1.71	No	No	0	6	4
237	R:R:G189	R:R:L188	1.71	No	No	0	4	5
238	R:R:G294	R:R:L293	1.71	No	No	0	7	8
239	R:R:G298	R:R:L297	1.71	No	No	0	5	7
240	R:R:M76	R:R:P77	1.68	Yes	No	0	7	9
241	R:R:L332	R:R:P306	1.64	No	No	0	8	9
242	R:R:S100	R:R:S154	1.63	No	No	0	6	7
243	R:R:A208	R:R:I124	1.62	No	No	0	6	8
244	R:R:A127	R:R:I128	1.62	No	No	0	8	7
245	R:R:A299	R:R:I339	1.62	No	No	0	5	6
246	R:R:S303	R:R:V335	1.62	No	No	0	7	4
247	R:R:S109	R:R:T67	1.6	No	No	0	9	8
248	R:R:S346	R:R:T345	1.6	No	Yes	0	5	7
249	R:R:T34	R:R:V30	1.59	Yes	No	0	5	3
250	R:R:T34	R:R:V31	1.59	Yes	No	0	5	5
251	R:R:A140	R:R:L144	1.58	No	No	0	3	4
252	R:R:T33	R:R:T34	1.57	No	Yes	0	6	5
253	R:R:I32	R:R:V31	1.54	No	No	0	7	5
254	R:R:I32	R:R:V335	1.54	No	No	0	7	4
255	R:R:I80	R:R:V84	1.54	No	No	0	6	5
256	R:R:I184	R:R:V180	1.54	No	No	0	5	3
257	R:R:I313	R:R:V321	1.54	No	Yes	0	5	3
258	R:R:M85	R:R:V84	1.52	No	No	0	4	5
259	R:R:I151	R:R:T104	1.52	No	No	0	5	6
260	R:R:I151	R:R:T148	1.52	No	No	0	5	4
261	R:R:K357	R:R:T49	1.5	No	No	0	6	4
262	R:R:K137	R:R:T135	1.5	No	No	0	5	8
263	R:R:L38	R:R:T34	1.47	No	Yes	0	4	5
264	R:R:L38	R:R:T37	1.47	No	No	0	4	6
265	R:R:I292	R:R:I296	1.47	No	No	0	8	8
266	R:R:K22	R:R:M23	1.44	No	No	0	3	5
267	R:R:I44	R:R:L41	1.43	No	No	0	7	5
268	R:R:Q176	R:R:T174	1.42	No	No	0	6	3
269	R:R:L24	R:R:M27	1.41	No	No	0	5	4
270	R:R:D86	R:R:M85	1.39	No	No	0	4	4
271	R:R:L302	R:R:L332	1.38	No	No	0	4	8
272	R:R:E286	R:R:K210	1.35	No	No	0	8	5
273	R:R:R138	R:R:T135	1.29	Yes	No	0	5	8
274	R:R:I313	R:R:Y319	1.21	No	No	0	5	7
275	R:R:E96	R:R:F93	1.17	No	No	0	6	3
276	R:R:N126	R:R:Y130	1.16	No	Yes	0	6	7
277	R:R:H179	R:R:Y182	1.09	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T34	1.555	4	0	5
2	R:R:N40	6.1275	4	0	9
3	R:R:I47	4.714	5	3	7
4	R:R:L53	5.988	5	3	8
5	R:R:L64	5.0675	4	2	9
6	R:R:D68	6.2875	4	2	9
7	R:R:V75	7.235	4	1	7
8	R:R:M76	4.355	4	0	7
9	R:R:W88	5.874	5	0	8
10	R:R:W98	6.875	4	0	5
11	R:R:C108	6.404	5	2	8
12	R:R:H112	6.15667	6	2	8
13	R:R:Y121	7.564	5	0	8
14	R:R:W122	9.15	5	4	4
15	R:R:Y130	7.49857	7	4	7
16	R:R:R134	6.335	4	4	7
17	R:R:R138	7.565	4	4	5
18	R:R:V146	4.7075	4	2	7
19	R:R:Y182	5.4	4	6	7
20	R:R:S186	4.1675	4	0	7
21	R:R:F191	9.15667	6	1	8
22	R:R:Y202	4.13667	6	0	9
23	R:R:W304	7.155	8	1	8
24	R:R:L305	5.5025	4	0	6
25	R:R:F307	8.64	4	1	7
26	R:R:F308	10.39	5	1	7
27	R:R:V321	3.1275	4	0	3
28	R:R:W331	8.035	6	1	6
29	R:R:Y334	7.64333	6	1	7
30	R:R:N340	7.76	5	2	9
31	R:R:Y344	6.198	5	2	9
32	R:R:T345	6.3825	4	3	7
33	R:R:F351	7.68857	7	3	8
34	L:L:?1	9.357	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W331	R:R:Y334	17.6552	8.68	Yes	Yes	1	6	7
2	R:R:V75	R:R:Y334	10.1874	6.31	Yes	Yes	1	7	7
3	R:R:V71	R:R:V75	15.7849	4.81	No	Yes	0	8	7
4	R:R:S337	R:R:V71	15.6231	3.23	No	No	0	9	8
5	R:R:D68	R:R:S337	16.0106	10.31	Yes	No	0	9	9
6	R:R:D68	R:R:N40	14.2852	6.73	Yes	Yes	0	9	9
7	L:L:?1	R:R:Y334	23.8121	9.2	Yes	Yes	1	0	7
8	L:L:?1	R:R:W304	41.4235	3.97	Yes	Yes	1	0	8
9	R:R:N336	R:R:W304	58.1688	14.69	No	Yes	0	9	8
10	R:R:N336	R:R:N340	61.0433	12.26	No	Yes	0	9	9
11	R:R:N340	R:R:Y344	88.0906	4.65	Yes	Yes	2	9	9
12	R:R:Y202	R:R:Y344	100	2.98	Yes	Yes	0	9	9
13	R:R:A117	R:R:Y202	96.3133	4	No	Yes	0	8	9
14	R:R:A117	R:R:L201	96.0538	3.15	No	No	0	8	5
15	R:R:L118	R:R:L201	45.3832	6.92	No	No	0	5	5
16	R:R:L118	R:R:W122	44.8709	17.08	No	Yes	0	5	4
17	R:R:W122	R:R:Y130	74.4254	17.36	Yes	Yes	4	4	7
18	R:R:R134	R:R:Y130	61.2253	12.35	Yes	Yes	4	7	7
19	R:R:P56	R:R:R134	59.6852	2.88	No	Yes	0	6	7
20	R:R:P56	R:R:Q55	58.4923	3.16	No	No	0	6	7
21	R:R:N58	R:R:Q55	57.0533	6.6	No	No	0	9	7
22	R:R:L53	R:R:N58	20.1793	6.87	Yes	No	3	8	9
23	R:R:I47	R:R:L53	15.5692	4.28	Yes	Yes	3	7	8
24	R:R:C62	R:R:I47	19.0166	8.18	No	Yes	0	6	7
25	R:R:C62	R:R:I44	15.8354	3.27	No	No	0	6	7
26	R:R:L201	R:R:Y121	50.4549	7.03	No	Yes	0	5	8
27	R:R:W122	R:R:Y121	46.3571	4.82	Yes	Yes	0	4	8
28	R:R:F351	R:R:N58	35.4115	4.83	Yes	No	3	8	9
29	R:R:F351	R:R:I47	15.7849	6.28	Yes	Yes	3	8	7
30	R:R:M142	R:R:W122	10.1402	3.49	No	Yes	0	7	4
31	R:R:H112	R:R:L64	26.6092	6.43	Yes	Yes	2	8	9
32	R:R:L64	R:R:N340	13.8674	5.49	Yes	Yes	2	9	9
33	R:R:I116	R:R:L64	11.9128	4.28	No	Yes	2	9	9
34	R:R:I116	R:R:Y344	11.9296	6.04	No	Yes	2	9	9
35	L:L:?1	R:R:M103	10.0795	8.63	Yes	No	0	0	7
36	L:L:?1	R:R:S186	12.0745	6.55	Yes	Yes	0	0	7
37	R:R:V75	R:R:W98	25.2814	6.13	Yes	Yes	0	7	5
38	R:R:W88	R:R:W98	17.5473	6.56	Yes	Yes	0	8	5
39	R:R:I110	R:R:W304	13.5944	5.87	No	Yes	0	8	8
40	R:R:I110	R:R:P194	12.5564	3.39	No	No	0	8	9
41	R:R:N126	R:R:Y130	10.0054	1.16	No	Yes	0	6	7
42	R:R:F191	R:R:W304	13.2709	4.01	Yes	Yes	1	8	8
43	R:R:F191	R:R:L305	11.5893	7.31	Yes	Yes	0	8	6
44	R:R:I296	R:R:Y202	11.1613	4.84	No	Yes	0	8	9
45	R:R:F307	R:R:K310	15.458	8.69	Yes	No	0	7	5
46	R:R:K310	R:R:V321	11.7847	4.55	No	Yes	0	5	3
47	R:R:D68	R:R:N340	25.2174	4.04	Yes	Yes	2	9	9
48	R:R:C108	R:R:H112	10.0829	4.42	Yes	Yes	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D102	R:R:V75	11.69	1	No	Yes	8	7	1	2
R:R:V75	R:R:Y334	6.31	1	Yes	Yes	7	7	2	1
R:R:S79	R:R:W331	6.18	1	No	Yes	6	6	2	2
R:R:S79	R:R:Y334	5.09	1	No	Yes	6	7	2	1
R:R:D102	R:R:Y334	10.34	1	No	Yes	8	7	1	1
L:L:?1	R:R:D102	13.02	1	Yes	No	0	8	0	1
R:R:M103	R:R:S154	7.67	0	No	No	7	7	1	2
L:L:?1	R:R:M103	8.63	1	Yes	No	0	7	0	1
R:R:C106	R:R:W304	5.22	1	No	Yes	7	8	1	1
L:L:?1	R:R:C106	9.69	1	Yes	No	0	7	0	1
R:R:I110	R:R:W304	5.87	0	No	Yes	8	8	2	1
R:R:I153	R:R:S186	3.1	0	No	Yes	6	7	2	1
R:R:E311	R:R:H177	12.31	0	No	No	6	5	1	2
R:R:S186	R:R:Y182	3.82	0	Yes	Yes	7	7	1	2
R:R:S186	R:R:T183	3.2	0	Yes	No	7	6	1	2
L:L:?1	R:R:S186	6.55	1	Yes	Yes	0	7	0	1
R:R:F308	R:R:T187	6.49	1	Yes	No	7	7	1	2
L:L:?1	R:R:A190	4.12	1	Yes	No	0	6	0	1
R:R:F191	R:R:F300	7.5	1	Yes	No	8	9	2	2
R:R:F191	R:R:W304	4.01	1	Yes	Yes	8	8	2	1
R:R:F191	R:R:F308	25.72	1	Yes	Yes	8	7	2	1
R:R:F300	R:R:W304	7.02	1	No	Yes	9	8	2	1
R:R:F308	R:R:W304	8.02	1	Yes	Yes	7	8	1	1
R:R:G333	R:R:W304	8.44	0	No	Yes	6	8	2	1
R:R:N336	R:R:W304	14.69	0	No	Yes	9	8	2	1
L:L:?1	R:R:W304	3.97	1	Yes	Yes	0	8	0	1
R:R:F307	R:R:F308	3.22	1	Yes	Yes	7	7	1	1
R:R:F307	R:R:K310	8.69	1	Yes	No	7	5	1	2
R:R:F307	R:R:T330	7.78	1	Yes	No	7	4	1	2
L:L:?1	R:R:F307	14.87	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F308	8.5	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:E311	15.02	1	Yes	No	0	6	0	1
R:R:T330	R:R:Y334	6.24	0	No	Yes	4	7	2	1
R:R:W331	R:R:Y334	8.68	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y334	9.2	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7E33_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	240
Number of Links	277
Number of Hubs	34
Number of Links mediated by Hubs	136
Number of Communities	6
Number of Nodes involved in Communities	54
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	49
Number Of Links MetaPath	48
Number of Shortest Paths	51339
Length Of Smallest Path	3
Average Path Length	13.8125
Length of Longest Path	29
Minimum Path Strength	1.375
Average Path Strength	6.3885
Maximum Path Strength	17.22
Minimum Path Correlation	0.7
Average Path Correlation	0.910368
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	40.694
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0719
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • periplasmic space • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HVU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HVU
Name	3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
Synonyms
Identifier
Formula	C14 H18 N2 O
Molecular Weight	230.306
SMILES
PubChem	2438
Formal Charge	0
Total Atoms	35
Total Chiral Atoms	0
Total Bonds	37
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28566
Sequence	>7E33_nogp_Chain_R T E K M L I C M T L V V I T T L T T L L N L A V I M A I G T T K K L H Q P A N Y L I C S L A V T D L L V A V L V M P L S I I Y I V M D R W K L G Y F L C E V W L S V D M T C C T C S I W H L C V I A L D R Y W A I T N A I E Y A R K R T A K R A A L M I L T V W T I S I F I S M P P L Q C T I Q H D H V I Y T I Y S T L G A F Y I P L T L I L I L Y Y R I Y H A A K S L S S T R E R K A A R I L G L I L G A F I L S W L P F F I K E L I V G L S I Y T V S S E V A D F L T W L G Y V N S L I N P L L Y T S F N E D F K L A F K K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E33	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	BRL-54443	-	Gi1/β1/γ2	2.9	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E33 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	BRL-54443	-		2.9	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8UGY	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Mianserin	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UGY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Mianserin	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855

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