CodeHVU
Name3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
Synonyms
Identifier3-(1-methylpiperidin-4-yl)-1~{H}-indol-5-ol
FormulaC14 H18 N2 O
Molecular Weight230.306
SMILESCN1CCC(CC1)c2c[nH]c3c2cc(cc3)O
PubChem2438
Formal Charge0
Total Atoms35
Total Chiral Atoms0
Total Bonds37
Total Aromatic Bonds10
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E33 A Amine 5-Hydroxytryptamine 5-HT1E Homo sapiens BRL-54443 - Gi1/Beta1/Gamma2 2.9 2021-04-14 10.1038/s41586-021-03376-8

A 2D representation of the interactions of HVU in 7E33
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D102 R:R:V75 11.69 4 No Yes 8 7 1 2
R:R:V75 R:R:Y334 6.31 4 Yes Yes 7 7 2 1
R:R:S79 R:R:W331 6.18 4 No Yes 6 6 2 2
R:R:S79 R:R:Y334 5.09 4 No Yes 6 7 2 1
R:R:D102 R:R:Y334 10.34 4 No Yes 8 7 1 1
L:L:?1 R:R:D102 13.02 4 Yes No 0 8 0 1
R:R:M103 R:R:S154 7.67 0 No No 7 7 1 2
L:L:?1 R:R:M103 8.63 4 Yes No 0 7 0 1
R:R:C106 R:R:W304 5.22 4 No Yes 7 8 1 1
L:L:?1 R:R:C106 9.69 4 Yes No 0 7 0 1
R:R:I110 R:R:W304 5.87 0 No Yes 8 8 2 1
R:R:I153 R:R:S186 3.1 0 No Yes 6 7 2 1
R:R:E311 R:R:H177 12.31 0 No No 6 5 1 2
R:R:S186 R:R:Y182 3.82 0 Yes Yes 7 7 1 2
R:R:S186 R:R:T183 3.2 0 Yes No 7 6 1 2
L:L:?1 R:R:S186 6.55 4 Yes Yes 0 7 0 1
R:R:F308 R:R:T187 6.49 4 Yes No 7 7 1 2
L:L:?1 R:R:A190 4.12 4 Yes No 0 6 0 1
R:R:F191 R:R:F300 7.5 4 Yes No 8 9 2 2
R:R:F191 R:R:W304 4.01 4 Yes Yes 8 8 2 1
R:R:F191 R:R:F308 25.72 4 Yes Yes 8 7 2 1
R:R:F300 R:R:W304 7.02 4 No Yes 9 8 2 1
R:R:F308 R:R:W304 8.02 4 Yes Yes 7 8 1 1
R:R:G333 R:R:W304 8.44 0 No Yes 6 8 2 1
R:R:N336 R:R:W304 14.69 0 No Yes 9 8 2 1
L:L:?1 R:R:W304 3.97 4 Yes Yes 0 8 0 1
R:R:F307 R:R:F308 3.22 4 Yes Yes 7 7 1 1
R:R:F307 R:R:K310 8.69 4 Yes No 7 5 1 2
R:R:F307 R:R:T330 7.78 4 Yes No 7 4 1 2
L:L:?1 R:R:F307 14.87 4 Yes Yes 0 7 0 1
L:L:?1 R:R:F308 8.5 4 Yes Yes 0 7 0 1
L:L:?1 R:R:E311 15.02 4 Yes No 0 6 0 1
R:R:T330 R:R:Y334 6.24 0 No Yes 4 7 2 1
R:R:W331 R:R:Y334 8.68 4 Yes Yes 6 7 2 1
L:L:?1 R:R:Y334 9.2 4 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.36
Average Nodes In Shell27.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.36
Average Nodes In Shell27.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)