psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L99	3.24	Yes	No	0	0	5
2	L:L:?1	R:R:D102	12.69	Yes	Yes	1	0	8
3	L:L:?1	R:R:M103	28.64	Yes	No	0	0	7
4	L:L:?1	R:R:C106	4.95	Yes	No	1	0	7
5	L:L:?1	R:R:T107	3.45	Yes	No	0	0	7
6	L:L:?1	R:R:I175	14.46	Yes	No	0	0	5
7	L:L:?1	R:R:W304	3.55	Yes	Yes	1	0	8
8	L:L:?1	R:R:F307	18.03	Yes	No	1	0	7
9	L:L:?1	R:R:F308	5.69	Yes	Yes	1	0	7
10	L:L:?1	R:R:E311	8.26	Yes	No	1	0	6
11	L:L:?1	R:R:T330	5.74	Yes	No	0	0	4
12	R:R:I80	R:R:L29	8.56	No	Yes	1	6	6
13	R:R:L29	R:R:W331	21.64	Yes	Yes	1	6	6
14	R:R:I32	R:R:W331	3.52	No	Yes	0	7	6
15	R:R:I32	R:R:L338	4.28	No	No	0	7	6
16	R:R:M76	R:R:T33	9.03	Yes	No	0	7	6
17	R:R:A72	R:R:T36	3.36	No	No	0	7	8
18	R:R:M76	R:R:T36	9.03	Yes	No	0	7	8
19	R:R:L338	R:R:T36	4.42	No	No	0	6	8
20	R:R:T37	R:R:V73	4.76	No	No	0	6	4
21	R:R:L342	R:R:L39	5.54	No	No	0	7	8
22	R:R:D68	R:R:N40	12.12	No	No	0	9	9
23	R:R:L69	R:R:N40	6.87	No	No	0	7	9
24	R:R:N40	R:R:P341	6.52	No	No	0	9	9
25	R:R:A65	R:R:V43	3.39	No	Yes	0	9	9
26	R:R:C62	R:R:I47	4.91	No	No	0	6	7
27	R:R:F351	R:R:I47	6.28	Yes	No	0	8	7
28	R:R:L358	R:R:T49	5.9	No	No	0	6	4
29	R:R:L53	R:R:T50	10.32	Yes	No	0	8	7
30	R:R:A354	R:R:T50	5.03	No	No	0	8	7
31	R:R:H54	R:R:K51	5.24	No	No	0	8	7
32	R:R:D350	R:R:K52	13.83	No	No	0	7	6
33	R:R:L53	R:R:N58	8.24	Yes	No	4	8	9
34	R:R:D350	R:R:L53	8.14	No	Yes	0	7	8
35	R:R:F351	R:R:L53	10.96	Yes	Yes	4	8	8
36	R:R:H54	R:R:Y59	5.44	No	No	0	8	5
37	R:R:N58	R:R:Q55	9.24	No	No	0	9	7
38	R:R:P56	R:R:R134	7.21	No	Yes	0	6	7
39	R:R:F351	R:R:N58	8.46	Yes	No	4	8	9
40	R:R:D119	R:R:L60	4.07	Yes	No	0	9	8
41	R:R:H112	R:R:S63	9.76	Yes	No	2	8	9
42	R:R:I143	R:R:S63	10.84	No	No	2	7	9
43	R:R:H112	R:R:L64	7.71	Yes	No	2	8	9
44	R:R:L113	R:R:L64	4.15	No	No	2	8	9
45	R:R:L64	R:R:N340	9.61	No	No	2	9	9
46	R:R:C105	R:R:T67	3.38	No	Yes	0	6	8
47	R:R:C108	R:R:T67	8.45	Yes	Yes	2	8	8
48	R:R:H112	R:R:T67	4.11	Yes	Yes	2	8	8
49	R:R:T67	R:R:W147	4.85	Yes	No	2	8	9
50	R:R:D68	R:R:S337	7.36	No	No	0	9	9
51	R:R:C105	R:R:V71	5.12	No	No	0	6	8
52	R:R:S337	R:R:V71	3.23	No	No	0	9	8
53	R:R:L74	R:R:V101	4.47	No	No	0	5	4
54	R:R:V75	R:R:W98	7.36	Yes	Yes	1	7	5
55	R:R:D102	R:R:V75	10.22	Yes	Yes	1	8	7
56	R:R:V75	R:R:Y334	3.79	Yes	Yes	1	7	7
57	R:R:M76	R:R:W331	5.82	Yes	Yes	1	7	6
58	R:R:M76	R:R:Y334	8.38	Yes	Yes	1	7	7
59	R:R:L78	R:R:W98	14.81	No	Yes	0	5	5
60	R:R:S79	R:R:W331	8.65	No	Yes	0	6	6
61	R:R:I80	R:R:W331	4.7	No	Yes	1	6	6
62	R:R:Q172	R:R:Y82	6.76	No	No	0	4	5
63	R:R:D327	R:R:I83	4.2	No	No	0	5	5
64	R:R:M85	R:R:V84	6.09	No	No	0	4	5
65	R:R:M85	R:R:R87	8.69	No	No	0	4	3
66	R:R:D86	R:R:Q172	3.92	No	No	0	4	4
67	R:R:K89	R:R:R87	4.95	No	No	0	4	3
68	R:R:L90	R:R:W88	7.97	No	Yes	0	6	8
69	R:R:L94	R:R:W88	3.42	No	Yes	0	4	8
70	R:R:C95	R:R:W88	7.84	No	Yes	1	9	8
71	R:R:W88	R:R:W98	9.37	Yes	Yes	1	8	5
72	R:R:C173	R:R:W88	5.22	No	Yes	1	9	8
73	R:R:E96	R:R:Y92	11.22	No	No	3	6	4
74	R:R:Q176	R:R:Y92	5.64	No	No	3	6	4
75	R:R:F93	R:R:V97	3.93	No	No	0	3	4
76	R:R:C173	R:R:C95	7.28	No	No	1	9	9
77	R:R:E96	R:R:R161	5.82	No	Yes	3	6	5
78	R:R:E96	R:R:Q176	5.1	No	No	3	6	6
79	R:R:L99	R:R:W98	3.42	No	Yes	0	5	5
80	R:R:D102	R:R:W98	3.35	Yes	Yes	1	8	5
81	R:R:C106	R:R:D102	4.67	No	Yes	1	7	8
82	R:R:D102	R:R:Y334	5.75	Yes	Yes	1	8	7
83	R:R:M103	R:R:Y182	3.59	No	Yes	0	7	7
84	R:R:S154	R:R:T104	7.99	Yes	No	0	7	6
85	R:R:C106	R:R:W304	6.53	No	Yes	1	7	8
86	R:R:S150	R:R:T107	6.4	No	No	0	8	7
87	R:R:A190	R:R:T107	5.03	No	No	0	6	7
88	R:R:C108	R:R:H112	5.9	Yes	Yes	2	8	8
89	R:R:C108	R:R:W147	16.98	Yes	No	2	8	9
90	R:R:C108	R:R:S150	3.44	Yes	No	0	8	8
91	R:R:I110	R:R:P194	3.39	No	No	0	8	9
92	R:R:I110	R:R:W304	10.57	No	Yes	0	8	8
93	R:R:C114	R:R:W111	3.92	No	Yes	0	7	5
94	R:R:I149	R:R:W111	9.4	No	Yes	0	5	5
95	R:R:I193	R:R:W111	3.52	No	Yes	6	6	5
96	R:R:P194	R:R:W111	14.86	No	Yes	6	9	5
97	R:R:H112	R:R:I143	5.3	Yes	No	2	8	7
98	R:R:H112	R:R:V146	6.92	Yes	No	0	8	7
99	R:R:L113	R:R:N340	6.87	No	No	2	8	9
100	R:R:L113	R:R:Y344	4.69	No	Yes	2	8	9
101	R:R:C114	R:R:L197	4.76	No	No	0	7	6
102	R:R:C114	R:R:I198	3.27	No	No	0	7	8
103	R:R:M142	R:R:V115	4.56	No	No	0	7	7
104	R:R:V115	R:R:V146	4.81	No	No	0	7	7
105	R:R:I116	R:R:R120	3.76	No	No	2	9	9
106	R:R:I116	R:R:Y344	6.04	No	Yes	2	9	9
107	R:R:A117	R:R:Y202	5.34	No	Yes	0	8	9
108	R:R:L118	R:R:W122	9.11	No	No	0	5	4
109	R:R:L118	R:R:L201	4.15	No	No	0	5	5
110	R:R:D119	R:R:Y130	10.34	Yes	No	5	9	7
111	R:R:D119	R:R:R134	9.53	Yes	Yes	5	9	7
112	R:R:R120	R:R:Y202	7.2	No	Yes	2	9	9
113	R:R:R120	R:R:Y344	8.23	No	Yes	2	9	9
114	R:R:W122	R:R:Y121	6.75	No	Yes	0	4	8
115	R:R:T125	R:R:Y121	11.24	No	Yes	0	7	8
116	R:R:L201	R:R:Y121	7.03	No	Yes	0	5	8
117	R:R:R204	R:R:Y121	6.17	No	Yes	0	6	8
118	R:R:I205	R:R:Y121	3.63	No	Yes	0	9	8
119	R:R:W122	R:R:Y130	14.47	No	No	0	4	7
120	R:R:A123	R:R:R134	4.15	No	Yes	0	8	7
121	R:R:E129	R:R:N126	15.77	No	No	0	5	6
122	R:R:E129	R:R:I128	5.47	No	No	0	5	7
123	R:R:E129	R:R:K133	4.05	No	No	0	5	5
124	R:R:R134	R:R:Y130	22.64	Yes	No	5	7	7
125	R:R:K133	R:R:R138	6.19	No	No	0	5	5
126	R:R:K137	R:R:T135	4.5	No	No	0	5	8
127	R:R:I151	R:R:M155	4.37	No	No	0	5	5
128	R:R:A190	R:R:I153	3.25	No	No	0	6	6
129	R:R:P156	R:R:P157	5.84	No	No	0	6	7
130	R:R:P157	R:R:R161	10.09	No	Yes	0	7	5
131	R:R:P157	R:R:Y182	12.52	No	Yes	0	7	7
132	R:R:F159	R:R:L158	3.65	No	No	0	5	6
133	R:R:R161	R:R:W160	6	Yes	Yes	0	5	7
134	R:R:D178	R:R:W160	7.82	No	Yes	0	6	7
135	R:R:H179	R:R:W160	10.58	No	Yes	0	6	7
136	R:R:W160	R:R:Y182	3.86	Yes	Yes	0	7	7
137	R:R:Q176	R:R:R161	12.85	No	Yes	3	6	5
138	R:R:H177	R:R:I175	6.63	Yes	No	0	5	5
139	R:R:H177	R:R:V314	5.54	Yes	No	0	5	2
140	R:R:G315	R:R:H177	4.77	No	Yes	0	5	5
141	R:R:H179	R:R:I181	3.98	No	No	0	6	4
142	R:R:S186	R:R:Y182	3.82	No	Yes	0	7	7
143	R:R:I184	R:R:L188	4.28	No	No	0	5	5
144	R:R:T187	R:R:Y192	3.75	No	Yes	1	7	5
145	R:R:F308	R:R:T187	7.78	Yes	No	1	7	7
146	R:R:L312	R:R:T187	4.42	No	No	1	5	7
147	R:R:L188	R:R:Y192	7.03	No	Yes	0	5	5
148	R:R:G189	R:R:I193	3.53	No	No	0	4	6
149	R:R:F191	R:R:Y192	6.19	Yes	Yes	1	8	5
150	R:R:F191	R:R:L195	8.53	Yes	Yes	1	8	6
151	R:R:F191	R:R:F300	4.29	Yes	No	1	8	9
152	R:R:F191	R:R:L305	6.09	Yes	Yes	0	8	6
153	R:R:F191	R:R:F308	21.43	Yes	Yes	1	8	7
154	R:R:L312	R:R:Y192	5.86	No	Yes	1	5	5
155	R:R:I193	R:R:P194	3.39	No	No	6	6	9
156	R:R:L195	R:R:L199	4.15	Yes	No	0	6	5
157	R:R:F300	R:R:L195	4.87	No	Yes	1	9	6
158	R:R:I301	R:R:L195	4.28	No	Yes	0	6	6
159	R:R:F300	R:R:I198	10.05	No	No	0	9	8
160	R:R:L199	R:R:L297	4.15	No	No	0	5	7
161	R:R:L293	R:R:Y202	4.69	No	Yes	0	8	9
162	R:R:I296	R:R:Y202	8.46	No	Yes	0	8	9
163	R:R:L297	R:R:Y202	5.86	No	Yes	0	7	9
164	R:R:Y202	R:R:Y344	4.96	Yes	Yes	2	9	9
165	R:R:R204	R:R:Y203	4.12	No	No	0	6	3
166	R:R:K210	R:R:Y206	13.14	No	No	0	5	5
167	R:R:A290	R:R:Y206	4	No	No	0	7	5
168	R:R:L293	R:R:Y206	3.52	No	No	0	8	5
169	R:R:Q214	R:R:Y213	3.38	No	Yes	0	5	4
170	R:R:A289	R:R:Y213	4	No	Yes	0	8	4
171	R:R:E286	R:R:R285	3.49	No	No	0	8	7
172	R:R:R285	R:R:R287	6.4	No	No	0	7	5
173	R:R:I292	R:R:K288	5.82	No	No	0	8	8
174	R:R:F347	R:R:I292	15.07	No	No	0	7	8
175	R:R:L295	R:R:L343	4.15	No	No	0	8	8
176	R:R:I296	R:R:L343	7.14	No	No	0	8	8
177	R:R:I301	R:R:L305	8.56	No	Yes	0	6	6
178	R:R:S303	R:R:W304	6.18	No	Yes	1	7	8
179	R:R:L332	R:R:S303	4.5	No	No	0	8	7
180	R:R:N336	R:R:S303	8.94	No	No	1	9	7
181	R:R:F308	R:R:W304	6.01	Yes	Yes	1	7	8
182	R:R:G333	R:R:W304	9.85	No	Yes	0	6	8
183	R:R:N336	R:R:W304	9.04	No	Yes	1	9	8
184	R:R:L305	R:R:P306	3.28	Yes	No	0	6	9
185	R:R:L329	R:R:P306	3.28	No	No	0	4	9
186	R:R:L332	R:R:P306	4.93	No	No	0	8	9
187	R:R:F307	R:R:K310	6.2	No	No	0	7	5
188	R:R:E311	R:R:F307	8.16	No	No	1	6	7
189	R:R:K310	R:R:L329	8.46	No	No	0	5	4
190	R:R:I318	R:R:Y319	4.84	No	No	0	5	7
191	R:R:S322	R:R:V325	6.46	No	No	0	5	4
192	R:R:F328	R:R:L329	3.65	No	No	0	4	4
193	R:R:T330	R:R:Y334	3.75	No	Yes	0	4	7
194	R:R:W331	R:R:Y334	20.26	Yes	Yes	1	6	7
195	R:R:N340	R:R:Y344	5.81	No	Yes	2	9	9
196	R:R:F347	R:R:L343	3.65	No	No	0	7	8
197	R:R:F351	R:R:T345	7.78	Yes	No	0	8	7
198	R:R:F347	R:R:S346	6.61	No	No	0	7	5
199	R:R:F351	R:R:N348	8.46	Yes	No	0	8	9
200	R:R:E349	R:R:K352	16.2	No	No	0	5	8
201	R:R:D350	R:R:L353	4.07	No	No	0	7	4
202	R:R:I359	R:R:K356	4.36	No	No	0	6	5
203	R:R:K357	R:R:L358	5.64	No	No	0	6	6
204	R:R:V314	R:R:V321	3.21	No	No	0	2	3
205	R:R:S109	R:R:T67	3.2	No	Yes	0	9	8
206	R:R:C105	R:R:L70	3.17	No	No	0	6	7
207	R:R:A46	R:R:L358	3.15	No	No	0	8	6
208	R:R:A117	R:R:L201	3.15	No	No	0	8	5
209	R:R:I80	R:R:V30	3.07	No	No	0	6	3
210	R:R:I47	R:R:V43	3.07	No	Yes	0	7	9
211	R:R:I44	R:R:V66	3.07	No	No	0	7	6
212	R:R:M103	R:R:S154	3.07	No	Yes	0	7	7
213	R:R:M155	R:R:S154	3.07	No	Yes	0	5	7
214	R:R:L141	R:R:T145	2.95	No	No	0	3	1
215	R:R:W88	R:R:Y82	2.89	Yes	No	0	8	5
216	R:R:I25	R:R:L29	2.85	No	Yes	0	4	6
217	R:R:I83	R:R:L29	2.85	No	Yes	0	5	6
218	R:R:I309	R:R:L305	2.85	No	Yes	0	7	6
219	R:R:I318	R:R:L316	2.85	No	No	0	5	3
220	R:R:I339	R:R:N336	2.83	No	No	0	6	9
221	R:R:G91	R:R:W88	2.81	No	Yes	0	7	8
222	R:R:A46	R:R:F355	2.77	No	No	0	8	7
223	R:R:H177	R:R:T183	2.74	Yes	No	0	5	6
224	R:R:A136	R:R:Y59	2.67	No	No	0	2	5
225	R:R:A209	R:R:Y213	2.67	No	Yes	0	8	4
226	R:R:F355	R:R:V43	2.62	No	Yes	0	7	9
227	R:R:F351	R:R:I61	2.51	Yes	No	0	8	8
228	R:R:M142	R:R:R138	2.48	No	No	0	7	5
229	R:R:K288	R:R:R291	2.48	No	No	0	8	8
230	R:R:E286	R:R:Y213	2.24	No	Yes	0	8	4
231	R:R:A139	R:R:P56	1.87	No	No	0	7	6
232	R:R:P341	R:R:V43	1.77	No	Yes	0	9	9
233	R:R:G298	R:R:I301	1.76	No	No	0	5	6
234	R:R:P77	R:R:T33	1.75	No	No	0	9	6
235	R:R:C26	R:R:V30	1.71	No	No	0	4	3
236	R:R:C62	R:R:V66	1.71	No	No	0	6	6
237	R:R:A72	R:R:V73	1.7	No	No	0	7	4
238	R:R:A326	R:R:V321	1.7	No	No	0	4	3
239	R:R:S100	R:R:S154	1.63	No	Yes	0	6	7
240	R:R:A208	R:R:I124	1.62	No	No	0	6	8
241	R:R:A299	R:R:I339	1.62	No	No	0	5	6
242	R:R:V321	R:R:V325	1.6	No	No	0	3	4
243	R:R:T34	R:R:V30	1.59	No	No	0	5	3
244	R:R:T34	R:R:V31	1.59	No	No	0	5	5
245	R:R:A57	R:R:D119	1.54	No	Yes	0	8	9
246	R:R:I313	R:R:V314	1.54	No	No	0	5	2
247	R:R:I32	R:R:T28	1.52	No	No	0	7	5
248	R:R:I200	R:R:T196	1.52	No	No	0	5	3
249	R:R:G217	R:R:R216	1.5	No	No	0	3	5
250	R:R:L35	R:R:V31	1.49	No	No	0	4	5
251	R:R:L74	R:R:V75	1.49	No	Yes	0	5	7
252	R:R:L24	R:R:T28	1.47	No	No	0	5	5
253	R:R:I313	R:R:I318	1.47	No	No	0	5	5
254	R:R:D327	R:R:S323	1.47	No	No	0	5	1
255	R:R:I19	R:R:M23	1.46	No	No	0	3	5
256	R:R:K22	R:R:M23	1.44	No	No	0	3	5
257	R:R:Q172	R:R:S171	1.44	No	No	0	4	2
258	R:R:E324	R:R:S322	1.44	No	No	0	1	5
259	R:R:L41	R:R:M45	1.41	No	No	0	5	4
260	R:R:E21	R:R:K22	1.35	No	No	0	4	3
261	R:R:A139	R:R:Y59	1.33	No	No	0	7	5
262	R:R:R138	R:R:T135	1.29	No	No	0	5	8
263	R:R:T174	R:R:Y82	1.25	No	No	0	3	5
264	R:R:I200	R:R:R204	1.25	No	No	0	5	6
265	R:R:I153	R:R:Y185	1.21	No	No	0	6	5
266	R:R:K210	R:R:Y213	1.19	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.88182	11	1	0
2	R:R:L29	8.975	4	1	6
3	R:R:V43	2.7125	4	0	9
4	R:R:L53	9.415	4	4	8
5	R:R:T67	4.798	5	2	8
6	R:R:V75	5.715	4	1	7
7	R:R:M76	8.065	4	1	7
8	R:R:W88	5.64571	7	1	8
9	R:R:W98	7.662	5	1	5
10	R:R:D102	7.336	5	1	8
11	R:R:C108	8.6925	4	2	8
12	R:R:W111	7.925	4	6	5
13	R:R:H112	6.61667	6	2	8
14	R:R:D119	6.37	4	5	9
15	R:R:Y121	6.964	5	0	8
16	R:R:R134	10.8825	4	5	7
17	R:R:S154	3.94	4	0	7
18	R:R:W160	7.065	4	0	7
19	R:R:R161	8.69	4	3	5
20	R:R:H177	4.92	4	0	5
21	R:R:Y182	5.9475	4	0	7
22	R:R:F191	9.306	5	1	8
23	R:R:Y192	5.7075	4	1	5
24	R:R:L195	5.4575	4	1	6
25	R:R:Y202	6.085	6	2	9
26	R:R:Y213	2.696	5	0	4
27	R:R:W304	7.39	7	1	8
28	R:R:L305	5.195	4	0	6
29	R:R:F308	10.2275	4	1	7
30	R:R:W331	10.765	6	1	6
31	R:R:Y334	8.386	5	1	7
32	R:R:Y344	5.946	5	2	9
33	R:R:F351	7.40833	6	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D102	73.2959	12.69	Yes	Yes	1	0	8
2	R:R:D102	R:R:Y334	51.4108	5.75	Yes	Yes	1	8	7
3	R:R:W331	R:R:Y334	64.5419	20.26	Yes	Yes	1	6	7
4	R:R:I80	R:R:W331	23.7379	4.7	No	Yes	1	6	6
5	L:L:?1	R:R:T330	46.5494	5.74	Yes	No	0	0	4
6	R:R:T330	R:R:Y334	45.0365	3.75	No	Yes	0	4	7
7	R:R:L29	R:R:W331	18.8509	21.64	Yes	Yes	1	6	6
8	R:R:I32	R:R:W331	16.2502	3.52	No	Yes	0	7	6
9	R:R:M76	R:R:Y334	31.472	8.38	Yes	Yes	1	7	7
10	R:R:M76	R:R:T36	20.2363	9.03	Yes	No	0	7	8
11	R:R:A72	R:R:T36	12.3321	3.36	No	No	0	7	8
12	L:L:?1	R:R:T107	84.7187	3.45	Yes	No	0	0	7
13	R:R:S150	R:R:T107	82.8149	6.4	No	No	0	8	7
14	R:R:C108	R:R:S150	82.7894	3.44	Yes	No	0	8	8
15	R:R:C108	R:R:T67	48.1812	8.45	Yes	Yes	2	8	8
16	R:R:C105	R:R:T67	81.829	3.38	No	Yes	0	6	8
17	R:R:C105	R:R:V71	76.9675	5.12	No	No	0	6	8
18	R:R:S337	R:R:V71	74.5113	3.23	No	No	0	9	8
19	R:R:D68	R:R:S337	72.0381	7.36	No	No	0	9	9
20	R:R:D68	R:R:N40	69.5479	12.12	No	No	0	9	9
21	R:R:N40	R:R:P341	64.5164	6.52	No	No	0	9	9
22	R:R:P341	R:R:V43	61.9752	1.77	No	Yes	0	9	9
23	R:R:I47	R:R:V43	44.0932	3.07	No	Yes	0	7	9
24	R:R:F351	R:R:I47	33.2653	6.28	Yes	No	0	8	7
25	R:R:F355	R:R:V43	14.083	2.62	No	Yes	0	7	9
26	R:R:A46	R:R:F355	11.6182	2.77	No	No	0	8	7
27	R:R:F351	R:R:L53	17.2276	10.96	Yes	Yes	4	8	8
28	L:L:?1	R:R:F308	100	5.69	Yes	Yes	1	0	7
29	R:R:F191	R:R:F308	97.8327	21.43	Yes	Yes	1	8	7
30	R:R:F191	R:R:L195	84.2087	8.53	Yes	Yes	1	8	6
31	R:R:L195	R:R:L199	90.2941	4.15	Yes	No	0	6	5
32	R:R:L199	R:R:L297	90.1751	4.15	No	No	0	5	7
33	R:R:L297	R:R:Y202	90.0051	5.86	No	Yes	0	7	9
34	R:R:A117	R:R:Y202	93.3367	5.34	No	Yes	0	8	9
35	R:R:A117	R:R:L201	90.9825	3.15	No	No	0	8	5
36	R:R:L118	R:R:L201	36.189	4.15	No	No	0	5	5
37	R:R:L118	R:R:W122	33.6223	9.11	No	No	0	5	4
38	R:R:W122	R:R:Y130	63.1651	14.47	No	No	0	4	7
39	R:R:R134	R:R:Y130	42.7333	22.64	Yes	No	5	7	7
40	R:R:P56	R:R:R134	32.1265	7.21	No	Yes	0	6	7
41	R:R:A139	R:R:P56	27.3585	1.87	No	No	0	7	6
42	R:R:A139	R:R:Y59	21.9191	1.33	No	No	0	7	5
43	R:R:H54	R:R:Y59	10.9893	5.44	No	No	0	8	5
44	R:R:L201	R:R:Y121	52.5327	7.03	No	Yes	0	5	8
45	R:R:W122	R:R:Y121	34.6252	6.75	No	Yes	0	4	8
46	R:R:D119	R:R:Y130	15.0858	10.34	Yes	No	5	9	7
47	R:R:C108	R:R:H112	34.2682	5.9	Yes	Yes	2	8	8
48	R:R:H112	R:R:L64	65.0943	7.71	Yes	No	2	8	9
49	R:R:L113	R:R:L64	32.2285	4.15	No	No	2	8	9
50	R:R:L64	R:R:N340	32.4069	9.61	No	No	2	9	9
51	L:L:?1	R:R:L99	24.2563	3.24	Yes	No	0	0	5
52	R:R:L99	R:R:W98	22.9475	3.42	No	Yes	0	5	5
53	R:R:W88	R:R:W98	45.351	9.37	Yes	Yes	1	8	5
54	R:R:W88	R:R:Y82	20.6187	2.89	Yes	No	0	8	5
55	R:R:Q172	R:R:Y82	12.6891	6.76	No	No	0	4	5
56	R:R:D102	R:R:W98	27.2055	3.35	Yes	Yes	1	8	5
57	R:R:I83	R:R:L29	11.4992	2.85	No	Yes	0	5	6
58	L:L:?1	R:R:M103	52.6007	28.64	Yes	No	0	0	7
59	R:R:M103	R:R:Y182	40.1496	3.59	No	Yes	0	7	7
60	R:R:P157	R:R:Y182	15.7913	12.52	No	Yes	0	7	7
61	R:R:P157	R:R:R161	11.2188	10.09	No	Yes	0	7	5
62	R:R:W160	R:R:Y182	20.4487	3.86	Yes	Yes	0	7	7
63	R:R:R161	R:R:W160	11.3038	6	Yes	Yes	0	5	7
64	R:R:M103	R:R:S154	11.7882	3.07	No	Yes	0	7	7
65	R:R:A190	R:R:T107	10.1139	5.03	No	No	0	6	7
66	L:L:?1	R:R:W304	24.7408	3.55	Yes	Yes	1	0	8
67	R:R:I110	R:R:W304	17.6101	10.57	No	Yes	0	8	8
68	R:R:I110	R:R:P194	14.9754	3.39	No	No	0	8	9
69	R:R:H112	R:R:V146	28.7948	6.92	Yes	No	0	8	7
70	R:R:L113	R:R:Y344	31.2766	4.69	No	Yes	2	8	9
71	R:R:N340	R:R:Y344	31.5145	5.81	No	Yes	2	9	9
72	R:R:Y202	R:R:Y344	59.434	4.96	Yes	Yes	2	9	9
73	R:R:V115	R:R:V146	25.9561	4.81	No	No	0	7	7
74	R:R:M142	R:R:V115	23.1005	4.56	No	No	0	7	7
75	R:R:R204	R:R:Y121	11.2783	6.17	No	Yes	0	6	8
76	R:R:M142	R:R:R138	20.2278	2.48	No	No	0	7	5
77	R:R:K133	R:R:R138	11.5077	6.19	No	No	0	5	5
78	L:L:?1	R:R:I175	32.152	14.46	Yes	No	0	0	5
79	R:R:H177	R:R:I175	30.2482	6.63	Yes	No	0	5	5
80	R:R:H177	R:R:V314	23.4404	5.54	Yes	No	0	5	2
81	R:R:F191	R:R:L305	12.7146	6.09	Yes	Yes	0	8	6
82	R:R:L293	R:R:Y202	30.6901	4.69	No	Yes	0	8	9
83	R:R:I296	R:R:Y202	22.2845	8.46	No	Yes	0	8	9
84	R:R:L293	R:R:Y206	28.2849	3.52	No	No	0	8	5
85	R:R:K210	R:R:Y206	22.6755	13.14	No	No	0	5	5
86	R:R:K210	R:R:Y213	19.8453	1.19	No	Yes	0	5	4
87	R:R:I296	R:R:L343	19.5903	7.14	No	No	0	8	8
88	R:R:F347	R:R:L343	14.1934	3.65	No	No	0	7	8
89	R:R:V314	R:R:V321	11.7542	3.21	No	No	0	2	3
90	R:R:I80	R:R:V30	20.4742	3.07	No	No	0	6	3
91	R:R:T34	R:R:V30	12.3321	1.59	No	No	0	5	3
92	R:R:H112	R:R:T67	39.3252	4.11	Yes	Yes	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L99	3.24	1	Yes	No	0	5	0	1
L:L:?1	R:R:D102	12.69	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M103	28.64	1	Yes	No	0	7	0	1
L:L:?1	R:R:C106	4.95	1	Yes	No	0	7	0	1
L:L:?1	R:R:T107	3.45	1	Yes	No	0	7	0	1
L:L:?1	R:R:I175	14.46	1	Yes	No	0	5	0	1
L:L:?1	R:R:W304	3.55	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F307	18.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:F308	5.69	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:E311	8.26	1	Yes	No	0	6	0	1
L:L:?1	R:R:T330	5.74	1	Yes	No	0	4	0	1
R:R:V75	R:R:W98	7.36	1	Yes	Yes	7	5	2	2
R:R:D102	R:R:V75	10.22	1	Yes	Yes	8	7	1	2
R:R:V75	R:R:Y334	3.79	1	Yes	Yes	7	7	2	2
R:R:L99	R:R:W98	3.42	0	No	Yes	5	5	1	2
R:R:D102	R:R:W98	3.35	1	Yes	Yes	8	5	1	2
R:R:C106	R:R:D102	4.67	1	No	Yes	7	8	1	1
R:R:D102	R:R:Y334	5.75	1	Yes	Yes	8	7	1	2
R:R:M103	R:R:Y182	3.59	0	No	Yes	7	7	1	2
R:R:C106	R:R:W304	6.53	1	No	Yes	7	8	1	1
R:R:S150	R:R:T107	6.4	0	No	No	8	7	2	1
R:R:A190	R:R:T107	5.03	0	No	No	6	7	2	1
R:R:I110	R:R:W304	10.57	0	No	Yes	8	8	2	1
R:R:H177	R:R:I175	6.63	0	Yes	No	5	5	2	1
R:R:F308	R:R:T187	7.78	1	Yes	No	7	7	1	2
R:R:F191	R:R:F308	21.43	1	Yes	Yes	8	7	2	1
R:R:S303	R:R:W304	6.18	1	No	Yes	7	8	2	1
R:R:N336	R:R:S303	8.94	1	No	No	9	7	2	2
R:R:F308	R:R:W304	6.01	1	Yes	Yes	7	8	1	1
R:R:G333	R:R:W304	9.85	0	No	Yes	6	8	2	1
R:R:N336	R:R:W304	9.04	1	No	Yes	9	8	2	1
R:R:F307	R:R:K310	6.2	1	No	No	7	5	1	2
R:R:E311	R:R:F307	8.16	1	No	No	6	7	1	1
R:R:T330	R:R:Y334	3.75	0	No	Yes	4	7	1	2
R:R:M103	R:R:S154	3.07	0	No	Yes	7	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UH3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	243
Number of Links	266
Number of Hubs	33
Number of Links mediated by Hubs	135
Number of Communities	6
Number of Nodes involved in Communities	51
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	42043
Length Of Smallest Path	3
Average Path Length	12.93
Length of Longest Path	29
Minimum Path Strength	1.385
Average Path Strength	7.05964
Maximum Path Strength	23.335
Minimum Path Correlation	0.7
Average Path Correlation	0.914324
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	50.4851
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.4994
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • serotonin binding • amine binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WOQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WOQ
Name	Setiptiline
Synonyms	[4a(13b)M,13aM]-2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine; Tecipul; delta(13b,4a),4a-Carba-mianserin; MO-8282; ORG-8282
Identifier
Formula	C19 H19 N
Molecular Weight	261.361
SMILES
PubChem	5205
Formal Charge	0
Total Atoms	39
Total Chiral Atoms	0
Total Bonds	42
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28566
Sequence	>8UH3_nogp_Chain_R I T E K M L I C M T L V V I T T L T T L L N L A V I M A I G T T K K L H Q P A N Y L I C S L A V T D L L V A V L V M P L S I I Y I V M D R W K L G Y F L C E V W L S V D M T C C T C S I W H L C V I A L D R Y W A I T N A I E Y A R K R T A K R A A L M I L T V W T I S I F I S M P P L F W R S P S Q C T I Q H D H V I Y T I Y S T L G A F Y I P L T L I L I L Y Y R I Y H A A K S L Y Q K R G R E R K A A R I L G L I L G A F I L S W L P F F I K E L I V G L S I Y T V S S E V A D F L T W L G Y V N S L I N P L L Y T S F N E D F K L A F K K L I R C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E33	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	BRL-54443	-	Gi1/β1/γ2	2.9	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E33 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	BRL-54443	-		2.9	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8UGY	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Mianserin	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UGY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Mianserin	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855

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