psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L99	5.56	Yes	No	0	0	5
2	L:L:?1	R:R:D102	17.44	Yes	Yes	1	0	8
3	L:L:?1	R:R:M103	15.9	Yes	No	0	0	7
4	L:L:?1	R:R:C106	5.1	Yes	No	1	0	7
5	L:L:?1	R:R:T107	3.55	Yes	No	0	0	7
6	L:L:?1	R:R:I175	14.9	Yes	No	0	0	5
7	L:L:?1	R:R:S186	3.62	Yes	No	0	0	7
8	L:L:?1	R:R:F307	13.69	Yes	Yes	1	0	7
9	L:L:?1	R:R:F308	8.8	Yes	Yes	1	0	7
10	L:L:?1	R:R:E311	12.77	Yes	No	1	0	6
11	L:L:?1	R:R:Y334	4.71	Yes	Yes	1	0	7
12	R:R:C26	R:R:V84	6.83	No	No	0	4	5
13	R:R:I80	R:R:L29	5.71	No	Yes	1	6	6
14	R:R:I83	R:R:L29	4.28	No	Yes	1	5	6
15	R:R:L29	R:R:W331	13.67	Yes	Yes	1	6	6
16	R:R:I32	R:R:W331	3.52	No	Yes	0	7	6
17	R:R:M76	R:R:T33	9.03	Yes	No	0	7	6
18	R:R:L338	R:R:L35	4.15	No	No	0	6	4
19	R:R:N40	R:R:T36	4.39	Yes	Yes	0	9	8
20	R:R:M76	R:R:T36	4.52	Yes	Yes	0	7	8
21	R:R:L338	R:R:T36	5.9	No	Yes	0	6	8
22	R:R:L69	R:R:T37	4.42	No	No	0	7	6
23	R:R:L342	R:R:L39	4.15	No	No	0	7	8
24	R:R:D68	R:R:N40	6.73	Yes	Yes	0	9	9
25	R:R:L69	R:R:N40	9.61	No	Yes	0	7	9
26	R:R:N40	R:R:P341	6.52	Yes	No	0	9	9
27	R:R:L41	R:R:L69	4.15	No	No	0	5	7
28	R:R:P341	R:R:V43	3.53	No	No	0	9	9
29	R:R:T345	R:R:V43	4.76	Yes	No	0	7	9
30	R:R:I44	R:R:V66	4.61	No	No	0	7	6
31	R:R:G48	R:R:I47	3.53	No	No	0	3	7
32	R:R:C62	R:R:I47	6.55	No	No	0	6	7
33	R:R:F351	R:R:I47	5.02	Yes	No	0	8	7
34	R:R:L53	R:R:T50	5.9	No	No	0	8	7
35	R:R:K357	R:R:T50	6.01	No	No	0	6	7
36	R:R:D350	R:R:K52	4.15	No	No	0	7	6
37	R:R:L53	R:R:N58	6.87	No	No	2	8	9
38	R:R:F351	R:R:L53	7.31	Yes	No	2	8	8
39	R:R:H54	R:R:Y59	8.71	No	No	0	8	5
40	R:R:N58	R:R:Q55	6.6	No	No	0	9	7
41	R:R:A57	R:R:R134	4.15	No	Yes	0	8	7
42	R:R:F351	R:R:N58	8.46	Yes	No	2	8	9
43	R:R:D119	R:R:L60	4.07	No	No	0	9	8
44	R:R:L60	R:R:M142	4.24	No	No	0	8	7
45	R:R:F351	R:R:I61	3.77	Yes	No	0	8	8
46	R:R:H112	R:R:S63	8.37	Yes	No	1	8	9
47	R:R:I143	R:R:S63	10.84	No	No	1	7	9
48	R:R:D68	R:R:L64	8.14	Yes	No	1	9	9
49	R:R:H112	R:R:L64	7.71	Yes	No	1	8	9
50	R:R:L64	R:R:N340	5.49	No	Yes	1	9	9
51	R:R:C108	R:R:T67	5.07	Yes	No	1	8	8
52	R:R:H112	R:R:T67	6.85	Yes	No	1	8	8
53	R:R:T67	R:R:W147	4.85	No	No	1	8	9
54	R:R:D68	R:R:S337	8.83	Yes	No	0	9	9
55	R:R:D68	R:R:N340	8.08	Yes	Yes	1	9	9
56	R:R:V71	R:R:V75	4.81	No	Yes	0	8	7
57	R:R:C105	R:R:V71	5.12	No	No	0	6	8
58	R:R:V75	R:R:W98	3.68	Yes	No	0	7	5
59	R:R:D102	R:R:V75	13.15	Yes	Yes	1	8	7
60	R:R:V75	R:R:Y334	5.05	Yes	Yes	1	7	7
61	R:R:M76	R:R:W331	9.31	Yes	Yes	1	7	6
62	R:R:M76	R:R:Y334	3.59	Yes	Yes	1	7	7
63	R:R:L78	R:R:W98	10.25	No	No	0	5	5
64	R:R:S79	R:R:W331	8.65	No	Yes	1	6	6
65	R:R:S79	R:R:Y334	3.82	No	Yes	1	6	7
66	R:R:I80	R:R:W331	3.52	No	Yes	1	6	6
67	R:R:I81	R:R:W88	3.52	No	Yes	0	5	8
68	R:R:W88	R:R:Y82	12.54	Yes	No	3	8	5
69	R:R:Q172	R:R:Y82	9.02	No	No	0	4	5
70	R:R:C173	R:R:Y82	6.72	Yes	No	3	9	5
71	R:R:D327	R:R:I83	11.2	No	No	0	5	5
72	R:R:I83	R:R:W331	3.52	No	Yes	1	5	6
73	R:R:K89	R:R:R87	22.28	No	No	0	4	3
74	R:R:R87	R:R:S171	5.27	No	No	0	3	2
75	R:R:L90	R:R:W88	17.08	No	Yes	3	6	8
76	R:R:L94	R:R:W88	4.56	No	Yes	3	4	8
77	R:R:C95	R:R:W88	5.22	No	Yes	3	9	8
78	R:R:C173	R:R:W88	7.84	Yes	Yes	3	9	8
79	R:R:L90	R:R:L94	4.15	No	No	3	6	4
80	R:R:P170	R:R:Y92	4.17	No	No	0	3	4
81	R:R:F93	R:R:V97	3.93	No	No	0	3	4
82	R:R:C173	R:R:C95	5.46	Yes	No	3	9	9
83	R:R:E96	R:R:S100	4.31	No	No	5	6	6
84	R:R:E96	R:R:L158	5.3	No	No	5	6	6
85	R:R:C173	R:R:W98	3.92	Yes	No	0	9	5
86	R:R:L158	R:R:S100	4.5	No	No	5	6	6
87	R:R:C106	R:R:D102	4.67	No	Yes	1	7	8
88	R:R:D102	R:R:Y334	10.34	Yes	Yes	1	8	7
89	R:R:M103	R:R:S154	6.13	No	Yes	0	7	7
90	R:R:M103	R:R:Y182	3.59	No	Yes	0	7	7
91	R:R:S154	R:R:T104	6.4	Yes	No	0	7	6
92	R:R:C106	R:R:W304	5.22	No	Yes	1	7	8
93	R:R:S150	R:R:T107	4.8	No	No	0	8	7
94	R:R:A190	R:R:T107	5.03	No	No	0	6	7
95	R:R:C108	R:R:H112	7.37	Yes	Yes	1	8	8
96	R:R:C108	R:R:W147	15.67	Yes	No	1	8	9
97	R:R:C108	R:R:S150	5.16	Yes	No	0	8	8
98	R:R:F300	R:R:I110	5.02	Yes	No	0	9	8
99	R:R:I110	R:R:W304	9.4	No	Yes	0	8	8
100	R:R:C114	R:R:W111	5.22	No	Yes	0	7	5
101	R:R:V146	R:R:W111	3.68	No	Yes	0	7	5
102	R:R:I149	R:R:W111	15.27	No	Yes	0	5	5
103	R:R:P194	R:R:W111	13.51	No	Yes	0	9	5
104	R:R:H112	R:R:I143	5.3	Yes	No	1	8	7
105	R:R:H112	R:R:V146	6.92	Yes	No	0	8	7
106	R:R:F300	R:R:L113	3.65	Yes	No	0	9	8
107	R:R:L113	R:R:N340	10.98	No	Yes	0	8	9
108	R:R:L113	R:R:Y344	7.03	No	Yes	0	8	9
109	R:R:C114	R:R:L197	4.76	No	No	0	7	6
110	R:R:V115	R:R:V146	4.81	No	No	0	7	7
111	R:R:I116	R:R:R120	7.52	No	No	7	9	9
112	R:R:I116	R:R:Y344	6.04	No	Yes	7	9	9
113	R:R:A117	R:R:Y202	5.34	No	Yes	0	8	9
114	R:R:L118	R:R:L201	6.92	No	No	0	5	5
115	R:R:D119	R:R:Y130	8.05	No	Yes	4	9	7
116	R:R:D119	R:R:R134	13.1	No	Yes	4	9	7
117	R:R:R120	R:R:Y202	8.23	No	Yes	0	9	9
118	R:R:R120	R:R:Y344	7.2	No	Yes	7	9	9
119	R:R:W122	R:R:Y121	4.82	No	Yes	0	4	8
120	R:R:T125	R:R:Y121	12.48	No	Yes	0	7	8
121	R:R:L201	R:R:Y121	7.03	No	Yes	0	5	8
122	R:R:R204	R:R:Y121	11.32	No	Yes	0	6	8
123	R:R:I205	R:R:Y121	3.63	No	Yes	0	9	8
124	R:R:W122	R:R:Y130	17.36	No	Yes	0	4	7
125	R:R:N126	R:R:T125	5.85	No	No	0	6	7
126	R:R:K133	R:R:Y130	3.58	No	Yes	4	5	7
127	R:R:R134	R:R:Y130	12.35	Yes	Yes	4	7	7
128	R:R:R138	R:R:Y130	6.17	No	Yes	4	5	7
129	R:R:K133	R:R:R138	8.66	No	No	4	5	5
130	R:R:I151	R:R:M155	4.37	No	No	0	5	5
131	R:R:P156	R:R:P157	5.84	No	No	6	6	7
132	R:R:P156	R:R:Y182	4.17	No	Yes	6	6	7
133	R:R:P157	R:R:Y182	15.3	No	Yes	6	7	7
134	R:R:H179	R:R:W160	29.62	No	No	0	6	7
135	R:R:H177	R:R:I175	9.28	No	No	0	5	5
136	R:R:D178	R:R:Q176	7.83	No	No	0	6	6
137	R:R:H177	R:R:V314	5.54	No	No	0	5	2
138	R:R:G315	R:R:H177	4.77	No	No	0	5	5
139	R:R:D178	R:R:H179	3.78	No	No	0	6	6
140	R:R:Y182	R:R:Y185	4.96	Yes	No	0	7	5
141	R:R:S186	R:R:Y182	11.45	No	Yes	0	7	7
142	R:R:G315	R:R:T183	3.64	No	No	0	5	6
143	R:R:T187	R:R:Y192	7.49	No	Yes	0	7	5
144	R:R:F308	R:R:T187	6.49	Yes	No	0	7	7
145	R:R:L188	R:R:Y192	5.86	No	Yes	0	5	5
146	R:R:F191	R:R:Y192	6.19	Yes	Yes	0	8	5
147	R:R:F191	R:R:F300	5.36	Yes	Yes	0	8	9
148	R:R:F191	R:R:W304	4.01	Yes	Yes	1	8	8
149	R:R:F191	R:R:L305	6.09	Yes	No	0	8	6
150	R:R:F191	R:R:F308	22.51	Yes	Yes	1	8	7
151	R:R:L195	R:R:L199	4.15	No	No	0	6	5
152	R:R:F300	R:R:L195	3.65	Yes	No	0	9	6
153	R:R:F300	R:R:I198	5.02	Yes	No	0	9	8
154	R:R:I200	R:R:R204	6.26	No	No	0	5	6
155	R:R:L293	R:R:Y202	3.52	No	Yes	0	8	9
156	R:R:I296	R:R:Y202	4.84	No	Yes	0	8	9
157	R:R:L297	R:R:Y202	7.03	No	Yes	0	7	9
158	R:R:H207	R:R:Y203	17.42	No	No	0	5	3
159	R:R:E286	R:R:Y206	4.49	No	No	0	8	5
160	R:R:L293	R:R:Y206	3.52	No	No	0	8	5
161	R:R:H207	R:R:K210	3.93	No	No	0	5	5
162	R:R:K210	R:R:Q214	4.07	No	No	0	5	5
163	R:R:E286	R:R:K210	6.75	No	No	0	8	5
164	R:R:L212	R:R:R216	3.64	No	No	0	7	5
165	R:R:R285	R:R:Y213	12.35	No	Yes	0	7	4
166	R:R:E286	R:R:Y213	14.59	No	Yes	0	8	4
167	R:R:A289	R:R:Y213	4	No	Yes	0	8	4
168	R:R:K215	R:R:R216	9.9	No	No	0	4	5
169	R:R:R216	R:R:R285	6.4	No	No	0	5	7
170	R:R:K288	R:R:R287	6.19	No	No	0	8	5
171	R:R:R287	R:R:R291	11.73	No	No	0	5	8
172	R:R:I292	R:R:K288	5.82	No	No	0	8	8
173	R:R:F347	R:R:I292	13.82	No	No	0	7	8
174	R:R:G298	R:R:I301	3.53	No	No	0	5	6
175	R:R:S303	R:R:W304	3.71	No	Yes	1	7	8
176	R:R:N336	R:R:S303	8.94	No	No	1	9	7
177	R:R:F308	R:R:W304	8.02	Yes	Yes	1	7	8
178	R:R:G333	R:R:W304	8.44	No	Yes	0	6	8
179	R:R:N336	R:R:W304	9.04	No	Yes	1	9	8
180	R:R:L329	R:R:P306	4.93	No	No	0	4	9
181	R:R:F307	R:R:K310	4.96	Yes	Yes	0	7	5
182	R:R:E311	R:R:F307	13.99	No	Yes	1	6	7
183	R:R:F307	R:R:T330	3.89	Yes	No	0	7	4
184	R:R:E311	R:R:F308	4.66	No	Yes	1	6	7
185	R:R:K310	R:R:V321	6.07	Yes	No	0	5	3
186	R:R:K310	R:R:L329	8.46	Yes	No	0	5	4
187	R:R:L312	R:R:L316	4.15	No	No	0	5	3
188	R:R:I313	R:R:I318	5.89	No	No	0	5	5
189	R:R:I318	R:R:Y319	3.63	No	No	0	5	7
190	R:R:E324	R:R:S322	8.62	No	No	0	1	5
191	R:R:F328	R:R:L329	3.65	No	No	0	4	4
192	R:R:T330	R:R:Y334	4.99	No	Yes	0	4	7
193	R:R:W331	R:R:Y334	15.43	Yes	Yes	1	6	7
194	R:R:N336	R:R:N340	13.62	No	Yes	1	9	9
195	R:R:I339	R:R:L343	4.28	No	No	0	6	8
196	R:R:F351	R:R:T345	11.67	Yes	Yes	0	8	7
197	R:R:F355	R:R:T345	6.49	No	Yes	0	7	7
198	R:R:E349	R:R:N348	5.26	No	No	2	5	9
199	R:R:D350	R:R:N348	6.73	No	No	2	7	9
200	R:R:F351	R:R:N348	9.67	Yes	No	2	8	9
201	R:R:D350	R:R:E349	3.9	No	No	2	7	5
202	R:R:A65	R:R:V43	3.39	No	No	0	9	9
203	R:R:I193	R:R:P194	3.39	No	No	0	6	9
204	R:R:A72	R:R:T36	3.36	No	Yes	0	7	8
205	R:R:A354	R:R:T50	3.36	No	No	0	8	7
206	R:R:S100	R:R:S154	3.26	No	Yes	0	6	7
207	R:R:A65	R:R:I44	3.25	No	No	0	9	7
208	R:R:A190	R:R:I153	3.25	No	No	0	6	6
209	R:R:S322	R:R:V325	3.23	No	No	0	5	4
210	R:R:A326	R:R:K310	3.21	No	Yes	0	4	5
211	R:R:V321	R:R:V325	3.21	No	No	0	3	4
212	R:R:T37	R:R:V73	3.17	No	No	0	6	4
213	R:R:P56	R:R:Q55	3.16	No	No	0	6	7
214	R:R:A117	R:R:L201	3.15	No	No	0	8	5
215	R:R:I32	R:R:V335	3.07	No	No	0	7	4
216	R:R:M155	R:R:S154	3.07	No	Yes	0	5	7
217	R:R:I32	R:R:T28	3.04	No	No	0	7	5
218	R:R:K137	R:R:T135	3	No	No	0	5	8
219	R:R:L74	R:R:V73	2.98	No	No	0	5	4
220	R:R:L38	R:R:T34	2.95	No	No	0	4	5
221	R:R:D68	R:R:S109	2.94	Yes	No	0	9	9
222	R:R:W160	R:R:Y182	2.89	No	Yes	0	7	7
223	R:R:Q214	R:R:S211	2.89	No	No	0	5	5
224	R:R:I25	R:R:L29	2.85	No	Yes	0	4	6
225	R:R:I184	R:R:L188	2.85	No	No	0	5	5
226	R:R:I301	R:R:L305	2.85	No	No	0	6	6
227	R:R:L338	R:R:L39	2.77	No	No	0	6	8
228	R:R:A46	R:R:F355	2.77	No	No	0	8	7
229	R:R:L70	R:R:L74	2.77	No	No	0	7	5
230	R:R:A123	R:R:R134	2.77	No	Yes	0	8	7
231	R:R:L295	R:R:L343	2.77	No	No	0	8	8
232	R:R:E129	R:R:I128	2.73	No	No	0	5	7
233	R:R:A136	R:R:Y59	2.67	No	No	0	2	5
234	R:R:A209	R:R:Y213	2.67	No	Yes	0	8	4
235	R:R:E129	R:R:N126	2.63	No	No	0	5	6
236	R:R:F347	R:R:L295	2.44	No	No	0	7	8
237	R:R:L312	R:R:Y192	2.34	No	Yes	0	5	5
238	R:R:L343	R:R:Y344	2.34	No	Yes	0	8	9
239	R:R:A139	R:R:P56	1.87	No	No	0	7	6
240	R:R:G189	R:R:I153	1.76	No	No	0	4	6
241	R:R:G189	R:R:I193	1.76	No	No	0	4	6
242	R:R:P77	R:R:T33	1.75	No	No	0	9	6
243	R:R:C105	R:R:V101	1.71	No	No	0	6	4
244	R:R:A208	R:R:T125	1.68	No	No	0	6	7
245	R:R:C26	R:R:I80	1.64	No	No	0	4	6
246	R:R:L332	R:R:P306	1.64	No	No	0	8	9
247	R:R:A123	R:R:I124	1.62	No	No	0	8	8
248	R:R:A208	R:R:I124	1.62	No	No	0	6	8
249	R:R:A299	R:R:I339	1.62	No	No	0	5	6
250	R:R:V30	R:R:V31	1.6	No	No	0	3	5
251	R:R:S346	R:R:T345	1.6	No	Yes	0	5	7
252	R:R:T33	R:R:V30	1.59	No	No	0	6	3
253	R:R:T34	R:R:T37	1.57	No	No	0	5	6
254	R:R:I184	R:R:V180	1.54	No	No	0	5	3
255	R:R:L197	R:R:T196	1.47	No	No	0	6	3
256	R:R:K22	R:R:M23	1.44	No	No	0	3	5
257	R:R:K89	R:R:M85	1.44	No	No	0	4	4
258	R:R:Q172	R:R:T174	1.42	No	No	0	4	3
259	R:R:Q176	R:R:T174	1.42	No	No	0	6	3
260	R:R:K52	R:R:L353	1.41	No	No	0	6	4
261	R:R:E21	R:R:I25	1.37	No	No	0	4	4
262	R:R:A139	R:R:Y59	1.33	No	No	0	7	5
263	R:R:H179	R:R:I181	1.33	No	No	0	6	4
264	R:R:A290	R:R:Y206	1.33	No	No	0	7	5
265	R:R:H54	R:R:K51	1.31	No	No	0	8	7
266	R:R:R138	R:R:T135	1.29	No	No	0	5	8
267	R:R:F152	R:R:I151	1.26	No	No	0	4	5
268	R:R:I309	R:R:Y192	1.21	No	Yes	0	7	5
269	R:R:Q172	R:R:R87	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.64	11	1	0
2	R:R:L29	6.6275	4	1	6
3	R:R:T36	4.5425	4	0	8
4	R:R:N40	6.8125	4	0	9
5	R:R:D68	6.944	5	1	9
6	R:R:V75	6.6725	4	1	7
7	R:R:M76	6.6125	4	1	7
8	R:R:W88	8.46	6	3	8
9	R:R:D102	11.4	4	1	8
10	R:R:C108	8.3175	4	1	8
11	R:R:W111	9.42	4	0	5
12	R:R:H112	7.08667	6	1	8
13	R:R:Y121	7.856	5	0	8
14	R:R:Y130	9.502	5	4	7
15	R:R:R134	8.0925	4	4	7
16	R:R:S154	4.715	4	0	7
17	R:R:C173	5.985	4	3	9
18	R:R:Y182	7.06	6	6	7
19	R:R:F191	8.832	5	1	8
20	R:R:Y192	4.618	5	0	5
21	R:R:Y202	5.792	5	0	9
22	R:R:Y213	8.4025	4	0	4
23	R:R:F300	4.54	5	0	9
24	R:R:W304	6.83429	7	1	8
25	R:R:F307	9.1325	4	1	7
26	R:R:F308	10.096	5	1	7
27	R:R:K310	5.675	4	0	5
28	R:R:W331	8.23143	7	1	6
29	R:R:Y334	6.84714	7	1	7
30	R:R:N340	9.5425	4	1	9
31	R:R:Y344	5.6525	4	7	9
32	R:R:T345	6.13	4	0	7
33	R:R:F351	7.65	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y334	48.5384	4.71	Yes	Yes	1	0	7
2	R:R:W331	R:R:Y334	13.514	15.43	Yes	Yes	1	6	7
3	R:R:M76	R:R:Y334	31.8331	3.59	Yes	Yes	1	7	7
4	R:R:M76	R:R:T36	40.2984	4.52	Yes	Yes	0	7	8
5	R:R:N40	R:R:T36	40.0061	4.39	Yes	Yes	0	9	8
6	R:R:L69	R:R:N40	12.7588	9.61	No	Yes	0	7	9
7	R:R:C106	R:R:W304	29.6407	5.22	No	Yes	1	7	8
8	R:R:N336	R:R:W304	18.7881	9.04	No	Yes	1	9	8
9	R:R:N336	R:R:N340	19.0195	13.62	No	Yes	1	9	9
10	R:R:D68	R:R:N340	34.9513	8.08	Yes	Yes	1	9	9
11	L:L:?1	R:R:F308	57.9476	8.8	Yes	Yes	1	0	7
12	R:R:D68	R:R:N40	40.5542	6.73	Yes	Yes	0	9	9
13	R:R:N40	R:R:P341	44.8965	6.52	Yes	No	0	9	9
14	R:R:P341	R:R:V43	43.6236	3.53	No	No	0	9	9
15	R:R:T345	R:R:V43	38.3922	4.76	Yes	No	0	7	9
16	R:R:F351	R:R:T345	32.9842	11.67	Yes	Yes	0	8	7
17	R:R:F351	R:R:N58	12.3264	8.46	Yes	No	2	8	9
18	R:R:N58	R:R:Q55	11.2058	6.6	No	No	0	9	7
19	R:R:F191	R:R:F308	53.4531	22.51	Yes	Yes	1	8	7
20	R:R:F191	R:R:F300	60.8831	5.36	Yes	Yes	0	8	9
21	R:R:F300	R:R:L113	68.6602	3.65	Yes	No	0	9	8
22	R:R:L113	R:R:Y344	100	7.03	No	Yes	0	8	9
23	R:R:R120	R:R:Y344	83.313	7.2	No	Yes	7	9	9
24	R:R:R120	R:R:Y202	82.2046	8.23	No	Yes	0	9	9
25	R:R:A117	R:R:Y202	50.9135	5.34	No	Yes	0	8	9
26	R:R:A117	R:R:L201	49.0682	3.15	No	No	0	8	5
27	R:R:L201	R:R:Y121	45.341	7.03	No	Yes	0	5	8
28	R:R:W122	R:R:Y121	24.0743	4.82	No	Yes	0	4	8
29	R:R:W122	R:R:Y130	22.0706	17.36	No	Yes	0	4	7
30	L:L:?1	R:R:T107	17.9233	3.55	Yes	No	0	0	7
31	R:R:S150	R:R:T107	10.4568	4.8	No	No	0	8	7
32	R:R:C108	R:R:S150	10.2314	5.16	Yes	No	0	8	8
33	R:R:L64	R:R:N340	10.5542	5.49	No	Yes	1	9	9
34	R:R:H112	R:R:L64	16.084	7.71	Yes	No	1	8	9
35	L:L:?1	R:R:D102	16.4251	17.44	Yes	Yes	1	0	8
36	R:R:D102	R:R:V75	38.0694	13.15	Yes	Yes	1	8	7
37	R:R:V71	R:R:V75	10.8648	4.81	No	Yes	0	8	7
38	R:R:V75	R:R:Y334	25.0853	5.05	Yes	Yes	1	7	7
39	R:R:V75	R:R:W98	49.4884	3.68	Yes	No	0	7	5
40	R:R:C173	R:R:W98	43.1912	3.92	Yes	No	0	9	5
41	R:R:C173	R:R:W88	13.8307	7.84	Yes	Yes	3	9	8
42	R:R:C173	R:R:Y82	23.1121	6.72	Yes	No	3	9	5
43	R:R:Q172	R:R:Y82	20.5847	9.02	No	No	0	4	5
44	R:R:Q172	R:R:R87	14.123	1.17	No	No	0	4	3
45	L:L:?1	R:R:M103	26.3155	15.9	Yes	No	0	0	7
46	R:R:M103	R:R:S154	12.6614	6.13	No	Yes	0	7	7
47	R:R:M103	R:R:Y182	13.7089	3.59	No	Yes	0	7	7
48	L:L:?1	R:R:S186	14.5128	3.62	Yes	No	0	0	7
49	R:R:S186	R:R:Y182	13.2278	11.45	No	Yes	0	7	7
50	R:R:I110	R:R:W304	10.3167	9.4	No	Yes	0	8	8
51	R:R:H112	R:R:V146	14.1474	6.92	Yes	No	0	8	7
52	R:R:V146	R:R:W111	10.8709	3.68	No	Yes	0	7	5
53	R:R:T125	R:R:Y121	14.2692	12.48	No	Yes	0	7	8
54	R:R:W160	R:R:Y182	15.4019	2.89	No	Yes	0	7	7
55	R:R:H179	R:R:W160	13.0207	29.62	No	No	0	6	7
56	R:R:F191	R:R:Y192	14.9147	6.19	Yes	Yes	0	8	5
57	R:R:L293	R:R:Y202	31.6078	3.52	No	Yes	0	8	9
58	R:R:L293	R:R:Y206	29.9695	3.52	No	No	0	8	5
59	R:R:E286	R:R:Y206	26.3155	4.49	No	No	0	8	5
60	R:R:E286	R:R:K210	10.609	6.75	No	No	0	8	5
61	R:R:E286	R:R:Y213	14.4336	14.59	No	Yes	0	8	4
62	R:R:L343	R:R:Y344	18.5627	2.34	No	Yes	0	8	9
63	R:R:L295	R:R:L343	12.363	2.77	No	No	0	8	8
64	R:R:F347	R:R:L295	10.609	2.44	No	No	0	7	8
65	L:L:?1	R:R:F307	18.4348	13.69	Yes	Yes	1	0	7
66	R:R:F307	R:R:K310	27.0767	4.96	Yes	Yes	0	7	5
67	R:R:K310	R:R:L329	11.0962	8.46	Yes	No	0	5	4
68	R:R:K310	R:R:V321	11.1023	6.07	Yes	No	0	5	3
69	R:R:C106	R:R:D102	24.8051	4.67	No	Yes	1	7	8
70	R:R:F191	R:R:W304	13.9647	4.01	Yes	Yes	1	8	8
71	R:R:L113	R:R:N340	44.5798	10.98	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L99	5.56	1	Yes	No	0	5	0	1
L:L:?1	R:R:D102	17.44	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M103	15.9	1	Yes	No	0	7	0	1
L:L:?1	R:R:C106	5.1	1	Yes	No	0	7	0	1
L:L:?1	R:R:T107	3.55	1	Yes	No	0	7	0	1
L:L:?1	R:R:I175	14.9	1	Yes	No	0	5	0	1
L:L:?1	R:R:S186	3.62	1	Yes	No	0	7	0	1
L:L:?1	R:R:F307	13.69	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F308	8.8	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:E311	12.77	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y334	4.71	1	Yes	Yes	0	7	0	1
R:R:D102	R:R:V75	13.15	1	Yes	Yes	8	7	1	2
R:R:V75	R:R:Y334	5.05	1	Yes	Yes	7	7	2	1
R:R:M76	R:R:W331	9.31	1	Yes	Yes	7	6	2	2
R:R:M76	R:R:Y334	3.59	1	Yes	Yes	7	7	2	1
R:R:S79	R:R:W331	8.65	1	No	Yes	6	6	2	2
R:R:S79	R:R:Y334	3.82	1	No	Yes	6	7	2	1
R:R:C106	R:R:D102	4.67	1	No	Yes	7	8	1	1
R:R:D102	R:R:Y334	10.34	1	Yes	Yes	8	7	1	1
R:R:M103	R:R:S154	6.13	0	No	Yes	7	7	1	2
R:R:M103	R:R:Y182	3.59	0	No	Yes	7	7	1	2
R:R:C106	R:R:W304	5.22	1	No	Yes	7	8	1	2
R:R:S150	R:R:T107	4.8	0	No	No	8	7	2	1
R:R:A190	R:R:T107	5.03	0	No	No	6	7	2	1
R:R:H177	R:R:I175	9.28	0	No	No	5	5	2	1
R:R:S186	R:R:Y182	11.45	0	No	Yes	7	7	1	2
R:R:F308	R:R:T187	6.49	1	Yes	No	7	7	1	2
R:R:F191	R:R:W304	4.01	1	Yes	Yes	8	8	2	2
R:R:F191	R:R:F308	22.51	1	Yes	Yes	8	7	2	1
R:R:F308	R:R:W304	8.02	1	Yes	Yes	7	8	1	2
R:R:F307	R:R:K310	4.96	1	Yes	Yes	7	5	1	2
R:R:E311	R:R:F307	13.99	1	No	Yes	6	7	1	1
R:R:F307	R:R:T330	3.89	1	Yes	No	7	4	1	2
R:R:E311	R:R:F308	4.66	1	No	Yes	6	7	1	1
R:R:T330	R:R:Y334	4.99	0	No	Yes	4	7	2	1
R:R:W331	R:R:Y334	15.43	1	Yes	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UGY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	238
Number of Links	269
Number of Hubs	33
Number of Links mediated by Hubs	139
Number of Communities	7
Number of Nodes involved in Communities	53
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	40205
Length Of Smallest Path	3
Average Path Length	11.9521
Length of Longest Path	26
Minimum Path Strength	1.295
Average Path Strength	6.89595
Maximum Path Strength	16.7
Minimum Path Correlation	0.7
Average Path Correlation	0.912189
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	48.1994
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.3975
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WRU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WRU
Name	Mianserin
Synonyms
Identifier
Formula	C18 H20 N2
Molecular Weight	264.365
SMILES
PubChem	154315
Formal Charge	0
Total Atoms	40
Total Chiral Atoms	1
Total Bonds	43
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28566
Sequence	>8UGY_nogp_Chain_R T E K M L I C M T L V V I T T L T T L L N L A V I M A I G T T K K L H Q P A N Y L I C S L A V T D L L V A V L V M P L S I I Y I V M D R W K L G Y F L C E V W L S V D M T C C T C S I W H L C V I A L D R Y W A I T N A I E Y A R K R T A K R A A L M I L T V W T I S I F I S M P P L F W P S Q C T I Q H D H V I Y T I Y S T L G A F Y I P L T L I L I L Y Y R I Y H A A K S L Y Q K R S T R E R K A A R I L G L I L G A F I L S W L P F F I K E L I V G L S I Y T V S S E V A D F L T W L G Y V N S L I N P L L Y T S F N E D F K L A F K K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	10.1126/sciadv.adk4855
	8UGY	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Mianserin	-	Gi1/β1/γ1	3.31	2024-05-01	10.1126/sciadv.adk4855
	8UGY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Mianserin	-		3.31	2024-05-01	10.1126/sciadv.adk4855
	7E33	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	BRL-54443	-	Gi1/β1/γ2	2.9	2021-04-14	10.1038/s41586-021-03376-8
	7E33 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	BRL-54443	-		2.9	2021-04-14	10.1038/s41586-021-03376-8

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