Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x39 5.7925408
22x40 4.9425408
32x42 5.005607
42x43 3.61408
52x50 7.186509
62x53 5.185408
72x54 3.95406
82x61 2.91447
9E1.Y103 7.172514
10E1x50 9.00333639
11E1x52 10.2825438
123x30 7.812565
133x37 5.2775407
143x51 4.275478
154x50 6.38409
164x65 10.59405
17E2x51 8.4175413
18E2.F193 8.724505
195x35 3.76404
205x36 9.536514
215x43 4.2775415
225x47 5.116529
235x58 7.2725409
246x48 6.96629
256x49 4.8575426
267x30 3.7515
277x53 6.154559
287x55 7.725406
29Lig 12.441510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1E1.Y103 Lig 24.856212.38YesYes140
25x43 Lig 71.78823.95YesYes150
33x37 5x43 89.93324.28YesYes075
43x36 3x37 92.3316.22NoYes087
53x36 6x48 92.64694.65NoYes089
63x40 6x48 97.74523.68NoYes079
73x40 5x50 97.91483.53NoNo079
83x44 5x50 97.72863.5NoNo079
93x44 5x54 98.66313.04NoNo078
103x47 5x54 98.79284.64NoNo098
113x47 5x58 1006.36NoYes099
123x50 5x58 53.70318.23NoYes099
133x50 7x53 43.55656.17NoYes599
143x43 7x53 63.52398.21NoYes089
153x43 7x49 62.32334.12NoNo089
162x50 7x49 61.09616.73YesNo099
172x50 7x46 37.49385.89YesNo099
182x54 7x46 36.07375.96YesNo069
192x53 2x54 30.32693.62YesYes086
202x53 7x42 24.47373.77YesNo087
212x57 7x42 18.51414.28NoNo087
222x57 2x61 13.91474.28NoYes487
235x58 6x40 45.76816.04YesNo098
246x40 7x53 44.48778.46NoYes089
251x50 2x50 24.473713.46NoYes099
261x50 7x50 22.99389.77NoNo099
272x43 7x53 33.59613.09YesYes089
282x40 2x43 26.5292.49YesYes088
292x40 8x49 19.29234.16YesNo086
301x56 8x49 17.96534.2NoNo076
311x56 1x60 16.63842.91NoNo074
321x59 1x60 12.1827.44NoNo054
332x42 3x46 12.3054.7YesNo079
343x33 5x43 18.71036.26NoYes045
353x33 4x57 17.66273.1NoNo047
362x63 E1.Y103 17.416611.91NoYes054
372x63 E1x50 32.345611.58NoYes059
38E1x50 E1x52 13.894723.05YesYes398
392x60 2x63 16.97436.53NoNo065
402x60 Lig 17.84239.05NoYes160
41E1x51 E1x52 10.0077.87NoYes038
423x25 E2.T180 11.82283.38NoNo094
43E2x52 Lig 10.645512.33NoYes150
443x47 5x57 20.60935.16NoNo097
453x51 5x57 11.1517.28YesNo087
465x58 6x37 12.15878.46YesNo098
475x62 6x37 11.15433.07NoNo058
485x62 6x34 10.06023.93NoNo057
497x50 7x55 12.4484.33NoYes096
505x39 5x43 10.82842.62NoYes055
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x602x636.531NoNo6512
2x60Lig9.051NoYes6010
2x63E1.Y10311.910NoYes5421
2x64E1.Y1035.340NoYes5421
2x67E1.Y1033.450NoYes4421
E1.Y103Lig12.381YesYes4010
3x335x436.260NoYes4521
3x375x434.280YesYes7521
4x65E2x528.440YesNo5521
E2.S188E2x513.960NoYes4321
E2.N192E2x516.040NoYes2321
E2x51Lig20.91YesYes3010
E2.F193E2x523.620YesNo5521
E2x52Lig12.331NoYes5010
5x36E2.F19318.11YesYes4512
5x365x406.851YesNo4612
5x366x587.391YesNo4411
5x366x597.711YesNo4512
5x36Lig7.631YesYes4010
5x43Lig3.951YesYes5010
6x516x5510.471NoNo6512
6x51Lig10.131NoYes6010
6x547x344.150NoNo4421
6x577x303.650NoYes5521
6x587x303.51NoYes4511
6x58Lig5.841NoYes4010
6x61E3.T2874.111NoNo2112
6x61Lig7.631NoYes2010
7x30Lig7.221YesYes5010
7x31Lig5.280NoYes4010
7x34Lig4.371NoYes4010
7x38Lig5.570NoYes6010
7x35E1.Y1032.780NoYes3421
E2.A181E2x512.770NoYes2321
5x39E2.F1932.620NoYes5522
5x395x432.620NoYes5521
7x297x302.620NoYes1521
7x277x301.510NoYes2521
6x517x411.331NoNo6812

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuschemerin_onOrthosteric Ligandcml1_on
72.22Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
68.42Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
58.82Single6OS2TRV0266OS2-AT1-TRV026
56.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
55.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
54.55Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
52.63Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
52.38Consensusangiotensin_onOrthosteric Ligandat1_on
52.38Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
50.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
50.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
50.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
48.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
47.83Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
47.83Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.62Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
47.62Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
47.37Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
47.37Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
45.45Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
45.45Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
44.44Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
44.44Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
43.48Single6JODAngiotensin II6JOD-AT2-Angiotensin II
43.48Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
42.86Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
42.11Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
41.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
41.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
40.91Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
40.91Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
40.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
40.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
40.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
40.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
40.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
40.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
39.13Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
39.13Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
38.46Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensusendothelin_onOrthosteric Ligandetb_on eta_on
38.10Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
38.10Single7XN9L-054,5227XN9-SST2-L-054,522
38.10Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
38.10Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
38.10Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
37.50Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
37.50Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
37.04Single8IY6Endothelin-18IY6-ETB-Endothelin-1
37.04Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
37.04Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.04Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
36.84Single6OS1TRV0266OS1-AT1-TRV026
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
36.36Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.36Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.36Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.36Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
36.36Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
36.36Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
36.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
36.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
36.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
35.71Single5GLHEndothelin-15GLH-ETB-Endothelin-1
35.71Single6IGKEndothelin-36IGK-ETB-Endothelin-3
35.71Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
35.29Single6MH8ZM2413856MH8-A2A-ZM241385
35.29Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
35.00Single6MXTSalmeterol6MXT-β2-Salmeterol
35.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
35.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
35.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
35.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
35.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
35.00Consensusdp_offOrthosteric Liganddp2_off
35.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
35.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
35.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
35.00Consensusnts_offOrthosteric Ligandnts1_off
34.78Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.78Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Consensussst_offOrthosteric Ligandsst2_off
34.78Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
34.62Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
34.48Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single6D27CAY104716D27-DP2-CAY10471
33.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
33.33Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
33.33Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
33.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
33.33Single7XNACYN1548067XNA-SST2-CYN154806
33.33Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
33.33Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
33.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
32.26Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
32.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
32.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Single5WF6UK-4320975WF6-A2A-UK-432097
31.82Single6KNMJN241-96KNM-Apelin-JN241-9
31.82Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
31.82Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.82Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
31.82Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
31.82Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
31.58Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.58Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
31.58Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.25Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
31.25Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
30.77Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
30.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
30.43Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
30.43Consensussst_onOrthosteric Ligandsst2_on sst4_on
30.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
30.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
30.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
30.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
30.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
30.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.63Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.63Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.41Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
29.41Single6AKYMaraviroc6AKY-CCR5-Maraviroc
29.41Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
29.41Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
29.41Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
29.41Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.41Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.17Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
29.17Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
29.17Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Single4XEENeurotensin4XEE-NTS1-Neurotensin
28.57Single4XESNeurotensin4XES-NTS1-Neurotensin
28.57Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
28.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
28.57Single6YVRNTS8-136YVR-NTS1-NTS8-13
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.57Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
28.57Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
28.57Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
28.57Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
28.00Single3OE0CVX153OE0-CXCR4-CVX15
28.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
28.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
27.78Single3REYPubChem 56973REY-A2A-PubChem 5697
27.78Single4MBSMaraviroc4MBS-CCR5-Maraviroc
27.78Single5K2BZM2413855K2B-A2A-ZM241385-Na
27.78Single5NLXZM2413855NLX-A2A-ZM241385-Na
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
27.78Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
27.78Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
27.78Single7AROLUF58337ARO-A2A-LUF5833-Na
27.78Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
27.78Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
27.78Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.78Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.78Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGTEpinephrine8GGT-β2-Epinephrine
27.78Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
27.78Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.78Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
27.59Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.59Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.59Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
27.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
27.27Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.27Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
27.27Single6IBLArformoterol6IBL-β1-Arformoterol
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
27.27Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.27Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
27.27Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
27.27Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusorexin_onOrthosteric Ligandox2_on
26.92Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.92Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.92Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.92Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single3EMLZM2413853EML-A2A-ZM241385
26.32Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.32Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6LPJZM2413856LPJ-A2A-ZM241385-Na
26.32Single6LPKZM2413856LPK-A2A-ZM241385-Na
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6S0LZM2413856S0L-A2A-ZM241385
26.32Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
26.32Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
26.32Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
26.32Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
26.32Single7UL4Alvimopan7UL4-μ-Alvimopan
26.32Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
26.32Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.32Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.32Single8K5DGSK2560738K5D-HCA2-GSK256073
26.32Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.32Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
26.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.09Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
26.09Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
26.09Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.09Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.09Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single4XT3Fractalkine4XT3-US28-Fractalkine
25.00Single5C1MBU725C1M-μ-BU72
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single6Z4SSR486926Z4S-NTS1-SR48692
25.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7F8XNN90567F8X-CCKA-NN9056
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7XKAEpinephrine7XKA-β2-Epinephrine
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8GGREpinephrine8GGR-β2-Epinephrine
25.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
25.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
25.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
24.14Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
24.14Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
24.00Single3QAKUK-4320973QAK-A2A-UK-432097
24.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
24.00Single7SK5CXCL127SK5-ACKR3-CXCL12
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
24.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Single3P0GBI1671073P0G-β2-BI167107
23.81Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
23.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.81Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.81Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
23.81Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
23.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.81Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.81Single7F1TMIP-1a7F1T-CCR5-MIP-1a
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.81Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
23.81Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.81Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.81Single7PX4PSB-21137PX4-A2A-PSB-2113
23.81Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.81Single8E0GBU728E0G-μ-BU72
23.81Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
23.81Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.81Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
23.81Consensusa2_onOrthosteric Liganda2a_on a2b_on
23.81Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
23.81Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
23.81Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.81Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.81Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.81Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Consensuslpa_offOrthosteric Ligandlpa1_off
23.81Consensuslpa_onOrthosteric Ligandlpa1_on
23.81Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.81Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.53Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGSEpinephrine8GGS-β2-Epinephrine
23.53Single8GGYEpinephrine8GGY-β2-Epinephrine
23.53Single8GH1Epinephrine8GH1-β2-Epinephrine
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.08Single5WF5UK-4320975WF5-A2A-UK-432097
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6PT2KGCHM076PT2-δ-KGCHM07
23.08Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
23.08Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
23.08Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
22.73Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
22.73Single4AMIBucindolol4AMI-β1-Bucindolol
22.73Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
22.73Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
22.73Single6A93Risperidone6A93-5-HT2A-Risperidone
22.73Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.73Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
22.73Single7K15MKD0467K15-BLT1-MKD046-Na
22.73Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
22.73Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.73Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.73Single7YITNalfurafine7YIT-κ-Nalfurafine
22.73Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.73Single8JJ8Formoterol8JJ8-β2-Formoterol
22.73Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
22.73Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
22.73Consensusblt_offOrthosteric Ligandblt1_off
22.73Consensuschemokine_offOrthosteric Ligandcxcr_off
22.73Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
22.73Consensuscxcr_offOrthosteric Ligandcxcr4_off
22.73Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
22.73Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
22.73Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.73Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
22.73Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
22.22Single3PWHZM2413853PWH-A2A-ZM241385
22.22Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
22.22Single4BWBNeurotensin4BWB-NTS1-Neurotensin
22.22Single5K2DZM2413855K2D-A2A-ZM241385
22.22Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
22.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.22Single5WS3EMPA5WS3-OX2-EMPA
22.22Single6AKXA4R6AKX-CCR5-A4R
22.22Single6JZHZM2413856JZH-A2A-ZM241385-Na
22.22Single6KUXRS-799486KUX-α2a-RS-79948
22.22Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
22.22Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Single6PS7ZM2413856PS7-A2A-ZM241385-Na
22.22Single7BR3Elagolix7BR3-GnRH1-Elagolix
22.22Single7F8ULintitript7F8U-CCKA-Lintitript
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
22.22Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.22Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGVEpinephrine8GGV-β2-Epinephrine
22.22Single8GGWEpinephrine8GGW-β2-Epinephrine
22.22Single8GGXEpinephrine8GGX-β2-Epinephrine
22.22Single8GH0Epinephrine8GH0-β2-Epinephrine
22.22Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
22.22Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
22.22Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
22.22Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
22.22Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.22Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
22.22Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
22.22Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
22.22Consensusorexin_offOrthosteric Ligandox2_off ox1_off
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
21.74Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
21.74Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.74Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.74Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
21.74Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.74Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.74Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.74Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
21.74Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.43Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
21.43Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
21.43Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.21Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.05Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.05Single5IU4ZM2413855IU4-A2A-ZM241385-Na
21.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
21.05Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.05Single5JTBZM2413855JTB-A2A-ZM241385
21.05Single5K2CZM2413855K2C-A2A-ZM241385-Na
21.05Single5NM4ZM2413855NM4-A2A-ZM241385-Na
21.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.05Single5UVIZM2413855UVI-A2A-ZM241385
21.05Single6AQFZM2413856AQF-A2A-ZM241385
21.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.05Single6PS4ICI 118-5516PS4-β2-ICI 118-551
21.05Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
21.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
21.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.05Single6TPGEMPA6TPG-OX2-EMPA
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
21.05Single6ZINSR486926ZIN-NTS1-SR48692
21.05Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.05Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Single7T32ZM2413857T32-A2A-ZM241385
21.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGIEpinephrine8GGI-β2-Epinephrine
21.05Single8GGKEpinephrine8GGK-β2-Epinephrine
21.05Single8GGMEpinephrine8GGM-β2-Epinephrine
21.05Single8GGPEpinephrine8GGP-β2-Epinephrine
21.05Single8GGQEpinephrine8GGQ-β2-Epinephrine
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
21.05Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Consensusgnrh_offOrthosteric Ligandgnrh1_off
21.05Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
21.05Consensushca_onOrthosteric Ligandhca2_on hca3_on
21.05Consensushcar_onOrthosteric Ligandhca_on
21.05Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
21.05Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
20.83Single3NY9PubChem 9131033NY9-β2-PubChem 913103
20.83Single4UG2CGS216804UG2-A2A-CGS21680
20.83Single6PT3DPI-2876PT3-δ-DPI-287
20.83Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7SK9CCX6627SK9-ACKR3-CCX662
20.83Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.83Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
20.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
20.83Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.83Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.69Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
20.69Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7SK3CXCL127SK3-ACKR3-CXCL12
20.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single2Y04Salbutamol2Y04-β1-Salbutamol
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
20.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
20.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
20.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
20.00Single4XT1Fractalkine4XT1-US28-Fractalkine
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
20.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5UENDU1725UEN-A1-DU172
20.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
20.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
20.00Single6PS1Timolol6PS1-β2-Timolol
20.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7BU7BI1671077BU7-β1-BI167107
20.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
20.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7PYRPSB-21157PYR-A2A-PSB-2115
20.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
20.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
20.00Single8GGNEpinephrine8GGN-β2-Epinephrine
20.00Single8GGOEpinephrine8GGO-β2-Epinephrine
20.00Single8GGUEpinephrine8GGU-β2-Epinephrine
20.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
20.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
20.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
20.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
20.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
20.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
20.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Consensusgi_hcarOrthosteric Ligandgi_hca
20.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
19.23Single6HLOAprepitant6HLO-NK1-Aprepitant
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
19.23Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
19.05Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
19.05Single2Y00Dobutamine2Y00-β1-Dobutamine
19.05Single2Y03Isoprenaline2Y03-β1-Isoprenaline
19.05Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
19.05Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
19.05Single5NM2ZM2413855NM2-A2A-ZM241385-Na
19.05Single5TVNLSD5TVN-5-HT2B-LSD
19.05Single5WIUNemonapride5WIU-D4-Nemonapride
19.05Single5WIVNemonapride5WIV-D4-Nemonapride-Na
19.05Single5WQCEMPA5WQC-OX2-EMPA
19.05Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
19.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
19.05Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
19.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.05Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
19.05Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
19.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
19.05Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.05Single6TP6Filorexant6TP6-OX1-Filorexant
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
19.05Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
19.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.05Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
19.05Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
19.05Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
19.05Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
19.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
19.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
19.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
19.05Single8QOTNanobody E8QOT-μ-Nanobody E
19.05Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
19.05Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
19.05Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
19.05Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
19.05Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
19.05Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
19.05Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
19.05Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
19.05Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
19.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.05Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
19.05Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
19.05Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
19.05Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
19.05Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
19.05Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
19.05Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.75Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.75Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
18.75Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
18.75Consensussensory_onOrthosteric Ligandopsin_on
18.52Single6W25SHU91196W25-MC4-SHU9119-Ca
18.52Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
18.52Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
18.18Single2YDVNECA2YDV-A2A-NECA
18.18Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
18.18Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.18Single4UHRCGS216804UHR-A2A-CGS21680
18.18Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
18.18Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
18.18Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
18.18Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
18.18Single5G53NECA5G53-A2A-NECA-Gs
18.18Single5X93K-87945X93-ETB-K-8794
18.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.18Single6J21Aprepitant6J21-NK1-Aprepitant
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.18Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
18.18Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
18.18Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
18.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
18.18Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
18.18Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
18.18Single7TUYGSK682753A7TUY-GPR183-GSK682753A
18.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
18.18Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
18.18Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
18.18Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
18.18Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
18.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
18.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
18.18Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
18.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
18.18Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
18.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
18.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
18.18Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
18.18Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
18.18Consensus5ht5_offOrthosteric Ligand5ht5a_off
18.18Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
18.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
18.18Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
18.18Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
18.18Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.18Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
18.18Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
18.18Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
18.18Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.86Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.86Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
17.86Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single4XNWMRS25004XNW-P2Y1-MRS2500
17.65Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
17.65Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
17.65Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.65Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.65Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.39Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
17.39Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
17.39Single4LDEBI1671074LDE-β2-BI167107
17.39Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.39Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
17.39Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.39Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
17.39Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
17.39Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Single7DFPSpiperone7DFP-D2-Spiperone
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.39Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.39Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
17.39Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
17.39Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Single8JWZAB9288JWZ-A2A-AB928-Na
17.39Single8WU1KCA8WU1-CB1-KCA-Arrestin1
17.39Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
17.39Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
17.39Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
17.39Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
17.39Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
17.39Consensusgi_class-fOther Ligandgi_frizzled
17.39Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
17.39Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
17.39Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
17.39Consensusnts_onOrthosteric Ligandnts1_on
17.39Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
17.39Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
17.39Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.24Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.24Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
17.14Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
17.14Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6FJ3PTH6FJ3-PTH1-PTH
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
16.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
16.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
16.67Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.67Single7UL2SR486927UL2-NTS1-SR48692-Na
16.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
16.67Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
16.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
16.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
16.67Single8K5BNiacin8K5B-HCA2-Niacin
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
16.67Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
16.67Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusclass-t_onOrthosteric Ligandtaste2_on
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusendothelin_offOrthosteric Ligandetb_off
16.67Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
16.67Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Consensusgs_class-tOrthosteric Ligandgs_taste
16.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.13Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
16.13Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.13Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.00Single5EE7MK08935EE7-Glucagon-MK0893
16.00Single5ZTYAM102575ZTY-CB2-AM10257
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8X5YAstemizole8X5Y-H1-Astemizole
16.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6ME2Ramelteon6ME2-MT1-Ramelteon
15.79Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.79Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
15.79Single6TODEMPA6TOD-OX1-EMPA-Na
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
15.79Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.79Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.79Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.79Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
15.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.79Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
15.79Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
15.79Single8IHKAcifran8IHK-HCA3-Acifran
15.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8IWESpermidine8IWE-TAAR9-Spermidine
15.79Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.79Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
15.79Consensusalpha1_onOrthosteric Ligandalpha1a_on
15.79Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.79Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.79Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
15.79Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.79Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.79Consensusgt_class-aOrthosteric Ligandgt_opsin
15.79Consensusgt_opsinOrthosteric Ligandgt_sensory
15.79Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.79Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
15.79Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
15.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon
15.62Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.62Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.62Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.62Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
15.38Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.38Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.15Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.15Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.00Single2YDOAdenosine2YDO-A2A-Adenosine
15.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
15.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
15.00Single6A94Zotepine6A94-5-HT2A-Zotepine
15.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
15.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
15.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single8GGLEpinephrine8GGL-β2-Epinephrine
15.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
15.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
15.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
15.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
15.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
15.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
15.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
15.00Single8K2WAMG4878K2W-CXCR3-AMG487
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.00Single8K5CAcipimox8K5C-HCA2-Acipimox
15.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
15.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
15.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
15.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.71Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
14.29Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
14.29Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
14.29Single4YAYZD-71554YAY-AT1-ZD-7155
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
14.29Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
14.29Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.29Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
14.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
14.29Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
14.29Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
14.29Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
14.29Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
14.29Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.29Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
14.29Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
14.29Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
14.29Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
14.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8JJOAlprenolol8JJO-β2-Alprenolol
14.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
14.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
14.29Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
14.29Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
14.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
14.29Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Consensusblt_onOrthosteric Ligandblt1_on
14.29Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
14.29Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.29Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
14.29Consensusleuko_onOrthosteric Ligandblt_on
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
14.29Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.29Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
14.29Consensustar_onOrthosteric Ligandta1_on
14.29Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
13.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
13.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.89Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.89Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.79Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.64Single5XPRBosentan5XPR-ETB-Bosentan
13.64Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.64Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.64Single6PS6Timolol6PS6-β2-Timolol
13.64Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.64Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
13.64Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.64Single7WC6LSD7WC6-5-HT2A-LSD
13.64Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
13.64Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
13.64Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.64Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
13.64Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.64Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.51Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single4DJHJDTic4DJH-κ-JDTic
13.04Single4U15Tiotropium4U15-M3-Tiotropium
13.04Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.04Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.04Single5XR8AM8415XR8-CB1-AM841
13.04Single5XRAAM115425XRA-CB1-AM11542
13.04Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.04Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.04Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.04Single6J20Aprepitant6J20-NK1-Aprepitant
13.04Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.04Single6OL9Tiotropium6OL9-M5-Tiotropium
13.04Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.04Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
13.04Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
13.04Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
13.04Single7W41PD1762527W41-BB2-PD176252
13.04Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
13.04Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
13.04Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
13.04Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
13.04Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
13.04Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
13.04Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.04Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.04Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.04Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.04Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.04Consensusbombesin_offOrthosteric Ligandbb2_off
13.04Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.04Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
13.04Consensushistamine_offOrthosteric Ligandh1_off
13.04Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
13.04Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
13.04Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.04Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.90Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
12.50Single4N4WSANT-14N4W-SMO-SANT-1
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
12.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.50Single6CM4Risperidone6CM4-D2-Risperidone
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single6ZG4HTL00099366ZG4-M1-HTL0009936
12.50Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
12.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
12.50Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
12.50Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
12.50Consensusclass-b2_onOrthosteric Ligandadgrg_on
12.50Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.20Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.12Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
12.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
12.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
12.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
12.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
12.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
12.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
11.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
11.54Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
11.54Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.11Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.11Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
11.11Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.11Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
11.11Single7WC5Psilocin7WC5-5-HT2A-Psilocin
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
11.11Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.11Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
11.11Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.53Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
10.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
10.53Single7SRQLSD7SRQ-5-HT2B-LSD
10.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.53Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
10.53Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
10.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
10.53Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.53Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.34Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.34Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.26Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
10.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.00Single4QINSAG1.54QIN-SMO-SAG1.5
10.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
10.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
10.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
10.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
10.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
10.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
10.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
10.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
10.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.68Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.68Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.52Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.52Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.52Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.52Single6IQLL7458706IQL-D4-L745870
9.52Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
9.52Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.52Single6TPNHTL66416TPN-OX2-HTL6641
9.52Single6VI4JDTic6VI4-κ-JDTic
9.52Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.52Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.52Single6ZG9GSK10347026ZG9-M1-GSK1034702
9.52Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
9.52Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
9.52Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
9.52Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
9.52Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
9.52Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
9.52Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
9.52Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
9.52Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.52Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.52Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.52Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.52Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
9.52Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
9.52Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
9.52Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
9.52Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
9.52Consensusgi_class-fOrthosteric Ligandgi_frizzled
9.52Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.52Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
9.52Consensuss1p_offOrthosteric Ligands1p1_off
9.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.09Single4DAJTiotropium4DAJ-M3-Tiotropium
9.09Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.09Single4MQSIperoxo4MQS-M2-Iperoxo
9.09Single4U14Tiotropium4U14-M3-Tiotropium
9.09Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
9.09Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
9.09Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
9.09Single6GPSMK08126GPS-CCR2-MK0812
9.09Single6IIVDaltroban6IIV-TP-Daltroban
9.09Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
9.09Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
9.09Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
9.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.09Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
9.09Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
9.09Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8X63Mepyramine8X63-H1-Mepyramine
9.09Single8X64Desloratadine8X64-H1-Desloratadine
9.09Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
9.09Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.09Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.09Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Consensushcar_offOrthosteric Ligandsuccinate_off
9.09Consensushistamine_onOrthosteric Ligandh1_on h4_on
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.09Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.09Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.09Consensustachykinin_offOrthosteric Ligandnk1_off
9.09Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
8.82Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
8.82Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.70Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
8.70Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
8.70Single5CGCHTL142425CGC-mGlu5-HTL14242
8.70Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.70Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.70Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.70Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
8.70Single6GPXMK08126GPX-CCR2-MK0812
8.70Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.70Single7C4SS1P7C4S-S1P3-S1P
8.70Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.70Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
8.70Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.70Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.70Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8EA0Iperoxo8EA0-M3-Iperoxo
8.70Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
8.70Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
8.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
8.70Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.70Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.70Consensusep_offOrthosteric Ligandep4_off
8.70Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
8.70Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.57Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
8.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.33Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
8.33Single5V56TC1145V56-SMO-TC114
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6E59L-7607356E59-NK1-L-760735
8.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.33Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.33Single7EPENAM5637EPE-mGlu-NAM563
8.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
8.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.33Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.33Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
8.33Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
8.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.33Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
8.33Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
8.11Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
8.11Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.00Single5X33BIIL2605X33-BLT1-BIIL260
8.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.00Single6HLPNetupitant6HLP-NK1-Netupitant
8.00Single6IIURamatroban6IIU-TP-Ramatroban
8.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
8.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
8.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
8.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
7.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69Single5CGDHTL142425CGD-mGlu5-HTL14242
7.69Single6K1QIRL25006K1Q-ETB-IRL2500
7.69Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
7.69Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.41Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusclass-d_offOrthosteric Ligandste2_off
7.41Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensusgs_class-b2Orthosteric Ligandgs_adgr
7.41Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
7.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.14Single7QA8Peptide7QA8-STE2-Peptide
7.14Single7QA8Peptide7QA8-STE2-Peptide
7.14Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.14Consensusclass-d_offOrthosteric Ligandste2_off
7.14Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
6.98Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.98Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.90Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.67Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.45Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.45Consensusclass-d_onOrthosteric Ligandste2_on
6.45Consensusgi_class-dOrthosteric Ligandgi_ste
6.45Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.25Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
6.06Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.06Consensusclass-d_onOrthosteric Ligandste2_on
5.88Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
5.88Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.88Consensusgi_class-dOrthosteric Ligandgi_ste
5.88Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
5.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.56Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.56Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.26Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.26Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.26Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.26Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
5.26Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.26Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.26Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.13Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
5.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
5.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
5.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
5.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76Single5DHHSB-6121115DHH-NOP-SB-612111
4.76Single5U09Taranabant5U09-CB1-Taranabant
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.76Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
4.76Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
4.76Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
4.76Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Consensusclass-f_offOrthosteric Ligandsmo_off
4.76Consensusmglu_onOther Ligandmglu2_on mglu4_on
4.76Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.55Single3RZECidoxepin3RZE-H1-Cidoxepin
4.55Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.55Single6TPKRetosiban6TPK-OT-Retosiban
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.55Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.55Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.55Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
4.55Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
4.55Consensussensory_offOrthosteric Ligandopsin_off
4.55Consensusvasopressin-ot_offOrthosteric Ligandot_off
4.35Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
4.35Single6FFHFenobam6FFH-mGlu5-Fenobam
4.35Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.17Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
4.17Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.00Single7P2L4YI7P2L-mGlu5-4YI
4.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
4.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.85Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.85Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.85Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
3.85Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
3.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.70Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
3.57Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2

Consensus Members
Id Members
8SG1 8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
Net Summary
Imin 3.04
Number of Linked Nodes 265
Number of Links 280
Number of Hubs 29
Number of Links mediated by Hubs 125
Number of Communities 7
Number of Nodes involved in Communities 38
Number of Links involved in Communities 44
Path Summary
Number Of Nodes in MetaPath 51
Number Of Links MetaPath 50
Number of Shortest Paths 50855
Length Of Smallest Path 3
Average Path Length 16.3586
Length of Longest Path 33
Minimum Path Strength 1.39
Average Path Strength 5.67429
Maximum Path Strength 17.315
Minimum Path Correlation 0.7
Average Path Correlation 0.928031
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 45.7494
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.2114
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
chemerin_oncml1_on



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