Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.45 2.41404
2G.S1.01 4.735416
3G.S1.02 6.04254105
4G.H1.01 5.80167659
5G.S2.01 5.29125419
6G.S2.05 6.40875413
7G.S2.08 8.0355105
8G.S3.03 8.3945107
9G.S3.04 5.575416
10G.S3.06 7.8325615
11G.S3.07 4.5775459
12G.s3h2.03 4.88417619
13G.H2.03 4.95419
14G.H2.04 5.023519
15G.H2.06 5.69687819
16G.H2.07 5.14571719
17G.h2s4.01 6.663519
18G.s4h3.03 6.4675438
19G.s4h3.04 9.039538
20G.H3.09 6.48167639
21G.H3.13 4.665435
22G.H3.14 5.685408
23G.H3.17 8.549515
24G.H3.18 6.0975409
25G.S5.05 5.45375459
26G.S5.07 5.895459
27G.HG.04 6.38539
28G.HG.15 6.0625407
29G.hgh4.02 7.28714737
30G.hgh4.05 9.042537
31G.H4.03 7.30417634
32G.H4.10 12.9825436
33G.S6.01 4.86625435
34G.S6.02 7.725167
35G.S6.05 6.23434
36G.H5.03 5.152558
37G.H5.08 5.4775108
38b.1x10 3.696254178
39b.h2x1 5.05625405
40b.h2x5 5.596254115
41b.lhb1x3 4.5185112
42b.lhb1x6 5.543754113
43b.b1x4 5.51625447
44b.l1x3 8.54917649
45b.b2x1 9.668518
46b.b2x3 4.91375446
47b.b2x5 6.85917647
48b.b3x2 6.37125445
49b.l3x2 5.63549
50b.b4x4 9.15625448
51b.b4x6 9.88357749
52b.l4x2 13.65444
53b.b5x2 5.7375407
54b.b5x3 6.81333649
55b.b5x5 5.6125405
56b.b5x7 5.92625407
57b.l5x1 4.6125498
58b.l5x5 7.96143719
59b.b6x5 4.07667696
60b.l6x5 6.94134
61b.b7x1 7.0675134
62b.b7x2 4.56498
63b.b7x4 3.7575498
64b.l7x2 4.82125419
65b.b8x1 4.135418
66b.b8x3 4.8535136
67b.b8x4 5.41696
68b.b9x3 4.9525496
69b.l9x3 7.259519
70b.l9x6 6.20611918
71b.b10x2 3.94486
72b.b10x5 5.5325609
73b.b11x4 5.61417619
74b.b11x5 4.78125486
75b.l11x2 8.31875419
76b.b12x3 4.235488
77b.b12x5 5.32375486
78b.b12x6 9.34071718
79b.b13x7 9.298587
80b.l13x3 9.435589
81b.l13x6 5.74125419
82b.l13x7 4.8975489
83b.b14x3 4.8775485
84b.b15x1 7.415589
85b.l15x1 5.26517
86b.b16x4 10.193586
87b.b16x5 4.8725405
88b.b16x6 10.356588
89b.b17x5 8.49125467
90b.b17x7 8.84468
91b.l17x3 10.3825669
92b.b18x3 5.6725468
93b.l18x1 6.7655146
94b.l18x2 6.18254147
95b.b19x2 7.789566
96b.b19x4 7.17125468
97b.l19x1 6.8475419
98b.l19x2 6.86375469
99b.b20x4 10.1908668
100b.b20x6 8.944566
101b.b20x7 5.70875409
102b.b21x1 9.774567
103b.b21x2 3.098506
104b.b21x5 6.61625404
105b.b21x7 6.94505
106b.l21x2 5.51875414
107b.l21x5 4.96125414
108b.l22x5 7.53756119
109b.b23x1 4.948505
110b.b23x2 4.79125406
111b.b23x6 7.23071717
112b.l23x1 7.9275416
113b.b24x4 7.395416
114b.b24x6 6.5675418
115b.l24x2 6.2885116
116b.l24x3 6.91405
117b.b25x3 6.858515
118b.l25x3 10.007579
119b.l25x6 12.4575418
120b.l27x1 11.3136719
121b.l27x2 8.7375479
122b.b28x2 7.995474
123b.b28x3 5.03875447
124b.b28x4 7.166576
125b.b28x6 8.99333679
126g.h1x8 3.88375407
127g.h2x9 3.624114
128g.h2x11 12.47254146
129g.ctx3 7.93875409
130g.ctx6 5.98125406
131g.ctx14 6.3225449
132g.ctx15 7.845449
133g.ctx16 5.23948
1341x43 5.50375427
1351x60 5.93214775
1362x42 5.56786708
1372x46 4.48375429
1382x50 6.834529
1392x52 4.8675407
1402x54 5.097526
1412x57 6.971507
1422x63 5.57525
143E1x50 5.27833627
1443x28 8.467524
1453x29 8.426524
1463x30 6.99375406
1473x43 4.75375408
1483x50 9.38754129
1493x51 7.125608
1504x38 3.4375407
1514x50 5.606509
152E2 18.15541224
1535x39 4.58625425
1545x47 6.9425408
1555x58 7.231509
1566x44 7.03529
1576x48 6.68417628
1586x51 6.65526
1596x55 11.4925426
1606x62 7.00125421
1617x34 6.69875424
1627x38 8.345425
1637x41 6.742527
1647x42 10.339527
1657x53 5.5075129
1668x50 7.589508
167Lig 8.64952020
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l26x5 g.ctx15 14.4555.87NoYes059
2b.l26x5 g.ctx4 28.87935.03NoNo057
3g.ctx3 g.ctx4 30.0594.025YesNo097
4b.l22x1 g.ctx3 14.16799.57NoYes099
5b.b23x1 b.l22x1 14.37484.5YesNo059
6b.b23x1 b.b24x5 32.77715.96YesNo055
7b.b23x3 b.b24x5 32.99855.96NoNo075
8b.b23x3 b.b26x3 33.11453.46NoNo076
9b.b22x2 b.b26x3 33.24736.01NoNo086
10b.b22x1 b.b22x2 33.42383.2NoNo088
11b.b22x1 b.l25x6 33.43613.88NoYes188
12b.l25x6 b.l27x1 63.743322.99YesYes189
13b.b2x1 b.l27x1 98.88299.645YesYes189
14b.b2x1 b.l3x1 99.775918.035YesNo189
15b.l3x1 b.l5x5 1005.475NoYes199
16G.h2s4.01 b.l5x5 43.42711.525YesYes199
17G.H2.07 G.h2s4.01 43.99744.01YesYes199
18G.H2.07 b.l9x6 31.3945.305YesYes198
19b.b10x1 b.l9x6 25.79054.455NoYes098
20b.b10x1 b.b11x5 25.53314.075NoYes096
21b.b10x2 b.b11x5 14.75763.44YesYes866
22b.b10x2 b.b10x4 14.28684.18YesNo066
23b.b10x4 b.b2x4 13.535720.31NoNo066
24b.b2x4 b.b6x5 13.26493.27NoYes066
25g.ctx3 g.ctx6 16.736911.535YesYes096
26b.b23x1 g.ctx6 15.81744.845YesYes056
27b.l5x5 b.l7x2 55.38735.695YesYes199
28G.H2.07 b.l7x2 43.19573.99YesYes199
29G.s3h2.03 b.l7x2 12.2865.32YesYes199
30G.s3h2.03 b.l9x6 11.83636.765YesYes198
313x51 3x55 12.76859.41YesNo087
323x55 5x64 13.27654.04NoNo075
335x64 5x68 13.78436.805NoNo055
345x68 G.H5.13 15.30646.55NoNo058
35G.H5.13 G.S6.02 16.31669.195NoYes087
36G.H5.10 G.S6.02 19.35636.005NoYes067
37G.H5.10 G.S5.03 19.86164.06NoNo068
38G.S4.03 G.S5.03 20.87152.94NoNo078
39G.S1.04 G.S4.03 21.88064.995NoNo077
40G.S1.04 G.S3.03 22.38494.26NoYes077
41G.S2.06 G.S3.03 32.425516.075NoYes097
42G.H1.08 G.S2.06 33.42516.17NoNo089
43G.H1.07 G.H1.08 33.92444.08NoNo098
44G.H1.07 G.s6h5.05 34.423610.195NoNo099
45G.H5.03 G.s6h5.05 34.92265.26YesNo089
46G.H5.03 G.s6h5.01 37.75915.85YesNo589
47G.S5.07 G.s6h5.01 39.759510.24YesNo599
48G.S5.07 G.s1h1.06 50.65185.94YesNo099
49G.s1h1.05 G.s1h1.06 51.14262.785NoNo099
50G.s1h1.05 G.s5hg.01 51.63323.06NoNo099
51G.S4.07 G.s5hg.01 34.64764.015NoNo089
52G.S4.07 G.s4h3.03 34.97074.635NoYes088
53G.H3.02 G.s4h3.03 35.94773.465NoYes388
54G.H3.02 G.hgh4.02 36.25024.19NoYes387
55G.H3.06 G.hgh4.02 43.83065.385NoYes067
56G.H3.06 G.H4.15 22.05015.6NoNo068
57G.H3.09 G.H4.15 22.95475.895YesNo098
58G.H3.09 G.S4.04 48.297913.93YesNo099
59G.H3.08 G.S4.04 70.06676.09NoNo099
60G.H2.04 G.H3.08 70.00264.86YesNo199
61G.H2.04 G.H2.07 70.18875YesYes199
62G.H3.06 G.h4s6.01 22.09875.655NoNo064
63G.H3.09 G.h4s6.01 22.2836.09YesNo094
64G.s4h3.02 G.s5hg.01 17.4848.415NoNo099
65G.HG.07 G.s4h3.02 17.6224.59NoNo399
66G.HG.07 G.s4h3.04 18.1285.975NoYes398
67G.HG.04 G.s4h3.04 19.09247.22YesYes398
68G.HG.04 G.s4h3.01 19.42979.135YesNo397
69G.S5.06 G.s4h3.01 19.76047.61NoNo087
70G.S5.04 G.S5.06 21.07033.46NoNo098
71G.S4.04 G.S5.04 21.69823.65NoNo099
722x43 7x53 40.19685.86NoYes1289
732x43 7x54 48.25225.495NoNo087
747x54 8x50 48.41820.935NoYes078
751x56 8x50 49.90152.52NoYes088
761x56 1x60 50.22882.62NoYes085
771x60 8x56 57.68134.28YesNo053
788x56 b.b24x1 57.83378.55NoNo034
79b.b24x1 b.l25x5 57.98874.225NoNo047
80b.l25x5 b.l27x1 58.14186.78NoYes079
81b.b20x7 b.b21x4 21.3179.5YesNo095
82b.b20x7 b.l20x3 19.02684.63YesNo097
83b.b21x2 b.l20x3 18.82483.035YesNo067
84b.1x18 b.b21x2 18.01442.92NoYes066
85b.1x18 b.b21x1 12.24767.745NoYes067
86b.b2x5 b.b3x2 10.117310.25YesYes475
87b.b2x5 b.l26x1 12.064811.525YesNo477
88b.l26x1 b.l26x3 12.44237.95NoNo477
89b.l26x3 b.l26x5 14.05386.235NoNo075
90b.l11x1 b.l9x6 12.76949.415NoYes198
91b.b11x6 b.l11x1 12.53383.71NoNo199
92b.b11x6 b.l9x3 10.920213.95NoYes199
93b.b20x5 b.b21x4 18.88884.155NoNo075
94b.b21x7 b.b24x6 27.208610.61YesYes058
95b.b23x6 b.b24x6 27.19246.27YesYes178
96b.l21x7 b.l23x1 30.14885.445NoYes156
976x51 Lig 18.02765.56YesYes260
986x48 6x51 18.66285.51YesYes286
996x44 6x48 22.754416.035YesYes298
1003x43 6x44 27.51895.65YesYes089
1013x43 7x53 31.63945.44YesYes089
102b.l23x1 b.l25x6 30.346918.46YesYes168
103b.b23x6 b.l21x7 29.18494.03YesNo175
104b.b20x5 b.b21x7 19.04125.86NoYes075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x322x644.8450NoNo5421
2x603x289.5552NoYes6422
2x607x387.1652NoYes6521
2x607x424.62NoYes6722
2x632x675.662YesNo5312
2x63E1x5052YesYes5712
2x633x284.2752YesYes5412
2x633x294.092YesYes5411
2x647x387.3052NoYes4511
2x64Lig8.6952NoYes4010
E1E24.2052NoYes4411
E1Lig8.422NoYes4010
3x28E1x504.012YesYes4722
E1x50E23.4052YesYes7421
E1x51E26.680NoYes3421
3x22E27.6252NoYes4421
3x25E24.5252NoYes9421
3x283x2911.712YesYes4421
3x294x614.122YesNo4412
3x294x6512.1752YesNo4412
3x29Lig10.0352YesYes4010
3x333x3712.912NoNo4612
3x336x5512.7952NoYes4611
3x33Lig8.2252NoYes4010
3x375x436.360NoNo6622
4x605x397.550NoYes7521
4x614x655.3752NoNo4422
4x645x353.460NoNo4422
4x645x393.530NoYes4521
E2E268.892YesYes4411
E2E2x5130.2452YesNo4312
E2Lig4.062YesYes4010
5x35E26.3452NoYes4421
6x62E211.142YesYes1411
5x39Lig4.222YesYes5010
5x436x553.2950NoYes6621
6x486x515.512YesYes8621
6x487x414.012YesYes8722
6x516x524.532YesNo6712
6x516x5513.3652YesYes6611
6x517x414.2852YesYes6712
6x51Lig5.562YesYes6010
6x547x345.090NoYes4421
6x55Lig16.5152YesYes6010
6x586x626.972NoYes4111
6x58Lig15.242NoYes4010
6x616x625.282NoYes2111
6x61Lig5.8452NoYes2010
6x62Lig4.6152YesYes1010
6x63E34.720NoNo1321
7x26E36.1950NoNo1321
7x307x343.7250NoYes4421
7x34Lig152YesYes4010
7x387x4211.8652YesYes5712
7x38Lig7.0452YesYes5010
7x417x4211.352YesYes7722
2x63Lig8.8252YesYes5010
5x395x423.0452YesNo5512
7x347x372.982YesNo4712
7x31Lig2.8752NoYes3010
3x32Lig2.6750NoYes6010
1x287x312.370NoNo4321
E3Lig2.162NoYes3010
5x34E21.8550NoYes2421
7x35Lig1.620NoYes4010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
63.64Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
63.64Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
60.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
56.52Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
56.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
55.56Single6IGLIRL16206IGL-ETB-IRL1620
54.17Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
53.85Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
53.57Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
52.63Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
52.38Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
52.38Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
52.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
51.85Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
51.85Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
51.85Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
50.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
50.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
50.00Single8ZRTET-18ZRT-ETB-ET-1
50.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
50.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
48.28Single5GLHEndothelin-15GLH-ETB-Endothelin-1
48.28Single6IGKEndothelin-36IGK-ETB-Endothelin-3
48.28Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
48.15Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
48.00Consensusangiotensin_onOrthosteric Ligandat1_on
48.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
47.83Single8QJ2pN1628QJ2-MC4-pN162-Gs
47.62Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
47.37Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
46.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
46.67Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
46.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
46.43Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
46.15Single6JODAngiotensin II6JOD-AT2-Angiotensin II
46.15Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
46.15Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
46.15Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
46.15Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
46.15Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.15Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
46.15Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
46.15Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
46.15Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
46.15Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
46.15Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
45.83Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
45.83Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
45.83Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
45.83Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
45.45Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
45.45Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
45.45Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
45.45Consensuslpa_offOrthosteric Ligandlpa1_off
45.45Consensuslpl_offOrthosteric Ligands1p_off lpa_off
45.16Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
45.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
45.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
45.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
44.83Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
44.83Single8IY6Endothelin-18IY6-ETB-Endothelin-1
44.83Consensusendothelin_onOrthosteric Ligandetb_on eta_on
44.83Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
44.44Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
44.44Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
44.44Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
44.44Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
44.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
44.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
44.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
43.48Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
43.48Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
42.86Single5N2RPSB-365N2R-A2A-PSB-36-Na
42.86Single5N2SPSB365N2S-A1-PSB36
42.86Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
42.86Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
42.31Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
42.31Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.31Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
42.11Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
41.94Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
41.94Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
41.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
41.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
41.67Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
41.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
41.67Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
41.67Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
41.67Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
41.67Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
41.38Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
41.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
41.38Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
41.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.38Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
41.18Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
40.91Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
40.91Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
40.91Single6OS1TRV0266OS1-AT1-TRV026
40.91Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
40.91Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
40.91Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
40.91Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
40.91Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
40.91Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusneurotensin_onOrthosteric Ligandnts1_on
40.91Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
40.74Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
40.74Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.74Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
40.74Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
40.74Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
40.74Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
40.00Single7AROLUF58337ARO-A2A-LUF5833-Na
40.00Single7F8XNN90567F8X-CCKA-NN9056
40.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
40.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
40.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
40.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
40.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
40.00Single8XWNCXCL88XWN-CXCR2-CXCL8
40.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
40.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusbradykinin_onOrthosteric Ligandbk2_on
40.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
40.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
40.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
40.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
40.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
40.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
40.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
40.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
39.29Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
39.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
39.29Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
39.29Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
39.29Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
39.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
39.13Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
39.13Single4XEENeurotensin4XEE-NTS1-Neurotensin
39.13Single4XESNeurotensin4XES-NTS1-Neurotensin
39.13Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
39.13Single6OS2TRV0266OS2-AT1-TRV026
39.13Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
39.13Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
39.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
39.13Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
39.13Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
39.13Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
39.13Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
39.13Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
39.13Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
39.13Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.13Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
39.13Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
39.13Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
39.13Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.13Consensusorexin_onOrthosteric Ligandox2_on
38.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
38.71Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
38.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.71Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.71Consensusbombesin_onOrthosteric Ligandbb2_on
38.71Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
38.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Single3QAKUK-4320973QAK-A2A-UK-432097
38.46Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
38.46Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
38.46Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
38.46Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
38.46Single7XNACYN1548067XNA-SST2-CYN154806
38.46Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
38.46Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.46Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
38.46Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.46Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
38.10Single5UIGCmpd-15UIG-A2A-Cmpd-1
38.10Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
38.10Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
38.10Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
38.10Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
38.10Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
38.10Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
38.10Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
37.93Single4XT3Fractalkine4XT3-US28-Fractalkine
37.93Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
37.93Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.93Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
37.93Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
37.93Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
37.93Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
37.50Single4BUONeurotensin4BUO-NTS1-Neurotensin
37.50Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
37.50Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
37.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
37.50Single7EZCUKA7EZC-A2A-UKA
37.50Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
37.50Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
37.50Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
37.50Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
37.50Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
37.50Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
37.50Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
37.50Consensuscck_onOrthosteric Ligandccka_on cckb_on
37.50Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
37.50Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
37.50Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
37.50Consensusprostanoid_offOrthosteric Ligandep_off dp_off
37.04Single3OE0CVX153OE0-CXCR4-CVX15
37.04Single5WF5UK-4320975WF5-A2A-UK-432097
37.04Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.04Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
37.04Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
37.04Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
37.04Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
37.04Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
37.04Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.04Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.04Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.04Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
37.04Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.04Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.04Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
36.84Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
36.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
36.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
36.36Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.36Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.36Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
36.36Single6D26Fevipiprant6D26-DP2-Fevipiprant
36.36Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
36.36Single6S0QZM-2413856S0Q-A2A-ZM-241385
36.36Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
36.36Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
36.36Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
36.36Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
36.36Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
36.36Single8GNEKW-63568GNE-A2A-KW-6356-Na
36.36Single8S4DCMF-0198S4D-Apelin-CMF-019
36.36Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
36.36Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.36Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
36.36Consensusdp_offOrthosteric Liganddp2_off
36.36Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
36.00Single4UG2CGS216804UG2-A2A-CGS21680
36.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
36.00Single5ZTYAM102575ZTY-CB2-AM10257
36.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
36.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
36.00Single7XN9L-054,5227XN9-SST2-L-054,522
36.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
36.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
36.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
36.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
36.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
36.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
35.71Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
35.71Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
35.71Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
35.71Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.00Single3PWHZM-2413853PWH-A2A-ZM-241385
35.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
35.00Single7F8ULintitript7F8U-CCKA-Lintitript
35.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
35.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
35.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
35.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
35.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
34.78Single4BV0Neurotensin4BV0-NTS1-Neurotensin
34.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
34.78Single5XR8AM8415XR8-CB1-AM841
34.78Single5XRAAM115425XRA-CB1-AM11542
34.78Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
34.78Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
34.78Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
34.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
34.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
34.78Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
34.78Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
34.78Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
34.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
34.78Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
34.78Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
34.78Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
34.78Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
34.78Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
34.78Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Consensuslpa_onOrthosteric Ligandlpa1_on
34.78Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
34.78Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
34.62Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.62Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
34.62Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
34.62Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.62Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.62Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
34.62Single8WDTphotoNECA8WDT-A2A-photoNECA
34.62Single8WKYPG-9348WKY-MC4-PG-934
34.62Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.62Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
34.62Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
34.62Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
34.62Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
34.62Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.62Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.62Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
34.62Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
34.62Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.62Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.62Consensussomatostatin_offOrthosteric Ligandsst2_off
34.48Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
34.48Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.48Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
34.48Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
34.48Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.48Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
34.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.38Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
34.38Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Single3REYXAC3REY-A2A-XAC
33.33Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
33.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
33.33Single6MXTSalmeterol6MXT-β2-Salmeterol
33.33Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
33.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7SK3CXCL127SK3-ACKR3-CXCL12
33.33Single7T32ZM-2413857T32-A2A-ZM-241385
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JJLOlodaterol8JJL-β2-Olodaterol
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
33.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Single8JWY2-1188JWY-A2A-2-118
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
33.33Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
33.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
33.33Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
33.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
33.33Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
33.33Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
33.33Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
33.33Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
33.33Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.26Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
32.26Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
32.26Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
32.14Single6PT2KGCHM076PT2-δ-KGCHM07
32.14Single6W25SHU91196W25-MC4-SHU9119-Ca
32.14Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
32.14Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
32.14Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
32.14Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.14Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
32.14Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
32.14Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
32.14Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
32.14Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.14Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
32.14Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
32.14Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
32.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
32.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
32.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
32.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
32.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
32.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
32.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
32.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
32.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
32.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
32.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
32.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
32.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
32.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
32.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
32.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
32.00Consensuschemerin_onOrthosteric Ligandcml1_on
32.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
32.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
32.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single3EMLZM-2413853EML-A2A-ZM-241385
31.82Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.82Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.82Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.82Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.82Single5UENDU1725UEN-A1-DU172
31.82Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.82Single6D27CAY104716D27-DP2-CAY10471
31.82Single6S0LZM-2413856S0L-A2A-ZM-241385
31.82Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
31.82Single7PYRPSB-21157PYR-A2A-PSB-2115
31.82Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
31.82Single7V3ZCP559407V3Z-CB1-CP55940
31.82Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
31.82Single8CU6LJ-45178CU6-A2A-LJ-4517
31.82Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
31.82Single8RLNLUF58348RLN-A2A-LUF5834
31.82Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
31.82Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
31.82Consensusa3_onOrthosteric Liganda3a_on
31.82Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
31.82Consensuscck_offOrthosteric Ligandccka_off
31.82Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
31.82Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
31.82Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
31.58Single4XNWMRS25004XNW-P2Y1-MRS2500
31.58Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.58Consensus5ht2_onOrthosteric Ligand5ht2b_on
31.58Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
31.25Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
31.03Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.03Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.03Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
31.03Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
30.77Single5WF6UK-4320975WF6-A2A-UK-432097
30.77Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
30.77Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.77Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
30.77Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.77Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
30.77Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.77Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
30.77Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.77Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.77Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8XQJJN2418XQJ-Apelin-JN241
30.77Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
30.77Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
30.77Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
30.77Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
30.77Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.77Consensuskisspeptin_onOrthosteric Ligandkiss1_on
30.77Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
30.77Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
30.77Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.77Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Single5XPRBosentan5XPR-ETB-Bosentan
30.43Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
30.43Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
30.43Single7C61Ergotamine7C61-5-HT1B-Ergotamine
30.43Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
30.43Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
30.43Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
30.43Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
30.43Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
30.43Single7W41PD1762527W41-BB2-PD176252
30.43Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.43Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
30.43Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
30.43Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.43Single8TF5Oleic acid8TF5-GPR6-Oleic acid
30.43Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
30.43Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
30.43Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
30.43Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
30.43Consensusa3_on_gpOrthosteric Liganda3a_on_gp
30.43Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.43Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.43Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.43Consensusbombesin_offOrthosteric Ligandbb2_off
30.43Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.43Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.43Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
30.43Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
30.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
30.43Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
30.43Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.43Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.43Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
30.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
30.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
30.00Single5L7IVismodegib5L7I-SMO-Vismodegib
30.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
30.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
30.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
30.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
30.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
30.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
30.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
30.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
30.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
29.63Single4XT1Fractalkine4XT1-US28-Fractalkine
29.63Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.63Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
29.63Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
29.63Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
29.63Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
29.63Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
29.63Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
29.63Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
29.63Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
29.63Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single3P0GBI1671073P0G-β2-BI167107
29.17Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
29.17Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
29.17Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
29.17Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
29.17Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
29.17Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.17Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
29.17Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.17Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
29.17Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
29.17Single7B6WCyclazosin7B6W-α1b-Cyclazosin
29.17Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
29.17Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
29.17Single7FEECP559407FEE-CB1-CP55940-ZCZ011
29.17Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
29.17Single7PX4PSB-21137PX4-A2A-PSB-2113
29.17Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
29.17Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
29.17Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
29.17Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
29.17Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
29.17Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
29.17Single8E0GBU728E0G-μ-BU72
29.17Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
29.17Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
29.17Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
29.17Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
29.17Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
29.17Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
29.17Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Single8XVLZibotentan8XVL-ETA-Zibotentan
29.17Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
29.17Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
29.17Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
29.17Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
29.17Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
29.17Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
29.17Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
29.17Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.17Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
29.03Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.03Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
28.57Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
28.57Single4BWBNeurotensin4BWB-NTS1-Neurotensin
28.57Single4QINSAG1.54QIN-SMO-SAG1.5
28.57Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
28.57Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
28.57Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
28.57Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7F8YDevazepide7F8Y-CCKA-Devazepide
28.57Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
28.57Single7SK5CXCL127SK5-ACKR3-CXCL12
28.57Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
28.57Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
28.57Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.57Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
28.57Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
28.57Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
28.57Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
28.57Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
28.57Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.57Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
28.57Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
28.57Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
28.57Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
28.57Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
28.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.00Single4LDEBI1671074LDE-β2-BI167107
28.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
28.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
28.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
28.00Single6KQICP559406KQI-CB1-CP55940-Org27569
28.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
28.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
28.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
28.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
28.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
28.00Single7YITNalfurafine7YIT-κ-Nalfurafine
28.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
28.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
28.00Single8JJ8Formoterol8JJ8-β2-Formoterol
28.00Single8JWZAB9288JWZ-A2A-AB928-Na
28.00Single8XWACXCL18XWA-CXCR2-CXCL1
28.00Single8XWMCXCL68XWM-CXCR2-CXCL6
28.00Single8XWSCXCL58XWS-CXCR2-CXCL5
28.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
28.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
28.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
28.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
28.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
28.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
28.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
28.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
28.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
27.59Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
27.59Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
27.59Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
27.27Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.27Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.27Single5JTBZM-2413855JTB-A2A-ZM-241385
27.27Single5UVIZM-2413855UVI-A2A-ZM-241385
27.27Single6AQFZM-2413856AQF-A2A-ZM-241385
27.27Single6IQLL7458706IQL-D4-L745870
27.27Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.27Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
27.27Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.27Single6ZINSR486926ZIN-NTS1-SR48692
27.27Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
27.27Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.27Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
27.27Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
27.27Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.27Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
27.27Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
27.27Single8K5CAcipimox8K5C-HCA2-Acipimox
27.27Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
27.27Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
27.27Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
27.27Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
27.27Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.27Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
27.27Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
27.27Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
27.27Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
27.27Consensusa2_offOrthosteric Liganda2a_off
27.27Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
27.27Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
27.27Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.27Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Consensusgrh_offOrthosteric Ligandgnrh1_off
26.92Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
26.92Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.92Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
26.92Single6H7LDobutamine6H7L-β1-Dobutamine
26.92Single6IBLArformoterol6IBL-β1-Arformoterol
26.92Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
26.92Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
26.92Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
26.92Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.92Single7UM4AS26747237UM4-5-HT5A-AS2674723
26.92Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
26.92Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
26.92Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
26.92Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
26.92Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
26.92Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8XVUCXCL28XVU-CXCR2-CXCL2
26.92Single8XWFCXCL38XWF-CXCR2-CXCL3
26.92Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
26.92Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.92Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.92Consensusendothelin_offOrthosteric Ligandetb_off
26.92Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
26.92Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
26.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.67Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
26.32Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Consensusp2y_offOrthosteric Ligandp2y1_off
26.09Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.09Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.09Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
26.09Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.09Single4QIMANTA XV4QIM-SMO-ANTA XV
26.09Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
26.09Single5T04Neurotensin5T04-NTS1-Neurotensin
26.09Single6DRXLisuride6DRX-5-HT2B-Lisuride
26.09Single6PS1Timolol6PS1-β2-Timolol
26.09Single6TOTLemborexant6TOT-OX1-Lemborexant
26.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.09Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.09Single7BU7BI1671077BU7-β1-BI167107
26.09Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.09Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
26.09Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
26.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.09Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
26.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
26.09Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
26.09Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
26.09Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
26.09Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.09Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.09Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.09Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
26.09Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
26.09Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
26.09Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
26.09Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
26.09Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Single8K5DGSK2560738K5D-HCA2-GSK256073
26.09Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
26.09Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
26.09Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
26.09Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.09Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
26.09Single9CHXS-Carazolol9CHX-β2-S-Carazolol
26.09Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
26.09Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
26.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.09Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.09Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
26.09Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
26.09Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
26.09Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
26.09Consensushca_on_gpOrthosteric Ligandhca2_on_gp
25.93Single3NY9ICI118-5513NY9-β2-ICI118-551
25.93Single6KNMJN241-96KNM-Apelin-JN241-9
25.93Single6PT3DPI-2876PT3-δ-DPI-287
25.93Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.93Single7SK9CCX6627SK9-ACKR3-CCX662
25.93Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.93Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
25.93Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.93Single8X5YAstemizole8X5Y-H1-Astemizole
25.93Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.93Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.81Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.81Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.81Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
25.00Single2Y00Dobutamine2Y00-β1-Dobutamine
25.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single5C1MBU725C1M-μ-BU72
25.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
25.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00Single6Z4SSR486926Z4S-NTS1-SR48692
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
25.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
25.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
25.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
25.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JXSPF-61428JXS-D1-PF-6142
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
25.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
24.32Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
24.24Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
24.14Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.14Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
24.14Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
24.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.00Single2YDVNECA2YDV-A2A-NECA
24.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
24.00Single4UHRCGS216804UHR-A2A-CGS21680
24.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
24.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
24.00Single5G53NECA5G53-A2A-NECA-Gs
24.00Single5V56TC1145V56-SMO-TC114
24.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
24.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
24.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
24.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
24.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
24.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
24.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
24.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
24.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
24.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
24.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
24.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
24.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
24.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
24.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
24.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
24.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
24.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
24.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
24.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
24.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
24.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
24.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
24.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
24.00Consensusa2_onOrthosteric Liganda2b_on
24.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
24.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
24.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
24.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
24.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
24.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
24.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
24.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
24.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
24.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
24.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
24.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
24.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
24.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
24.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
24.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
24.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.81Single3OE9IT1t3OE9-CXCR4-IT1t
23.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.81Single7SRQLSD7SRQ-5-HT2B-LSD
23.81Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
23.81Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
23.81Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
23.81Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
23.81Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
23.81Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
23.81Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.81Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
23.81Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.81Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
23.81Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
23.81Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.53Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
23.53Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
23.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
23.33Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.33Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
23.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.33Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.33Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.33Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Single3D4STimolol3D4S-β2-Timolol
23.08Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
23.08Single6A93Risperidone6A93-5-HT2A-Risperidone
23.08Single6CM4Risperidone6CM4-D2-Risperidone
23.08Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
23.08Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.08Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
23.08Single6ZG4HTL00099366ZG4-M1-HTL0009936
23.08Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
23.08Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
23.08Single7K15MKD0467K15-BLT1-MKD046-Na
23.08Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.08Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
23.08Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8XQJJN2418XQJ-Apelin-JN241
23.08Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
23.08Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.08Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.08Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.86Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.73Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
22.73Single3ODUIT1t3ODU-CXCR4-IT1t
22.73Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
22.73Single4S0VSuvorexant4S0V-OX2-Suvorexant
22.73Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
22.73Single5WS3EMPA5WS3-OX2-EMPA
22.73Single6AKXA4R6AKX-CCR5-A4R
22.73Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
22.73Single6TODEMPA6TOD-OX1-EMPA-Na
22.73Single6TPJSuvorexant6TPJ-OX2-Suvorexant
22.73Single7BR3Elagolix7BR3-GnRH1-Elagolix
22.73Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
22.73Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
22.73Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
22.73Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
22.73Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.73Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
22.73Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
22.73Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
22.73Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.73Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.73Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
22.73Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.73Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
22.73Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
22.73Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
22.73Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
22.73Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
22.73Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
22.73Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
22.73Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.73Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
22.73Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
22.73Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.73Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
22.73Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
22.73Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
22.73Consensusalpha2_offOrthosteric Ligandalpha2c_off
22.73Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
22.73Consensusorexin_offOrthosteric Ligandox2_off ox1_off
22.73Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
22.73Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
22.73Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
22.73Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.58Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.58Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.58Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
22.58Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.58Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.58Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
22.58Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.58Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.58Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.58Consensusvasop-oxy_onOrthosteric Ligandv2_on
22.58Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
22.22Single5X93K-87945X93-ETB-K-8794
22.22Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
22.22Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
22.22Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.22Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
22.22Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
22.22Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
22.22Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
22.22Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
22.22Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
22.22Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
22.22Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
22.22Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
21.88Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.88Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.88Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.88Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
21.88Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.74Single2YDOAdenosine2YDO-A2A-Adenosine
21.74Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
21.74Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
21.74Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.74Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.74Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.74Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.74Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
21.74Single6PS0S-Carazolol6PS0-β2-S-Carazolol
21.74Single6PS4ICI118-5516PS4-β2-ICI118-551
21.74Single6PS5S-Propranolol6PS5-β2-S-Propranolol
21.74Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.74Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.74Single6TPGEMPA6TPG-OX2-EMPA
21.74Single6TPNHTL66416TPN-OX2-HTL6641
21.74Single6V9SGTPL114036V9S-OX1-GTPL11403
21.74Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.74Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
21.74Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.74Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
21.74Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
21.74Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
21.74Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
21.74Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
21.74Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
21.74Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
21.74Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.74Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
21.74Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
21.74Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
21.74Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
21.74Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
21.74Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
21.74Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
21.74Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.74Single8IHKAcifran8IHK-HCA3-Acifran
21.74Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.74Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.74Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.74Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
21.74Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.74Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
21.74Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
21.74Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.74Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
21.74Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
21.74Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
21.74Consensusalpha1_onOrthosteric Ligandalpha1a_on
21.74Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
21.74Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.74Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.74Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.74Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.74Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.74Consensushca_onOrthosteric Ligandhca2_on
21.74Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
21.43Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
21.43Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
21.43Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.21Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
21.21Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
21.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
21.05Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
21.05Single8PWNTheophylline8PWN-A2A-Theophylline
21.05Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single2Y01Dobutamine2Y01-β1-Dobutamine
20.83Single2Y02Carmoterol2Y02-β1-Carmoterol
20.83Single2Y04Salbutamol2Y04-β1-Salbutamol
20.83Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.83Single3NY8ICI118-5513NY8-β2-ICI118-551
20.83Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
20.83Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.83Single4GBRS-Carazolol4GBR-β2-S-Carazolol
20.83Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.83Single4QKX35V4QKX-β2-35V
20.83Single4YAYZD-71554YAY-AT1-ZD-7155
20.83Single5DHGC-355DHG-NOP-C-35
20.83Single5DHHSB-6121115DHH-NOP-SB-612111
20.83Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.83Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.83Single5TGZAM65385TGZ-CB1-AM6538
20.83Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.83Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.83Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.83Single6GPSMK08126GPS-CCR2-MK0812
20.83Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.83Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.83Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
20.83Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.83Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.83Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.83Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
20.83Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.83Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.83Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
20.83Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.83Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.83Single7UL4Alvimopan7UL4-μ-Alvimopan
20.83Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
20.83Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.83Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.83Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.83Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.83Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
20.83Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
20.83Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
20.83Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
20.83Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
20.83Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
20.83Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
20.83Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.83Single8JJOAlprenolol8JJO-β2-Alprenolol
20.83Single8JXRLSD8JXR-D1-LSD
20.83Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.83Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.83Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.83Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.83Single8X63Mepyramine8X63-H1-Mepyramine
20.83Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
20.83Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.83Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.83Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.83Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
20.83Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
20.83Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.83Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.83Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.83Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
20.83Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.83Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.83Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.83Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.83Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.83Consensusdopamine_offOrthosteric Ligandd2_off d3_off
20.83Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
20.83Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
20.83Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.83Consensushistamine_offOrthosteric Ligandh1_off
20.69Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.69Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.69Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8IEBA1LYA8IEB-GPR156-A1LYA
20.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
20.59Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.59Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.59Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
20.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
20.00Single3OE8IT1t3OE8-CXCR4-IT1t
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single4JKVTaladegib4JKV-SMO-Taladegib
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
20.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
20.00Single5WQCEMPA5WQC-OX2-EMPA
20.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6HLOAprepitant6HLO-NK1-Aprepitant
20.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
20.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
20.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
20.00Single6TP6Filorexant6TP6-OX1-Filorexant
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
20.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.00Single7WC6LSD7WC6-5-HT2A-LSD
20.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
20.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
20.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
20.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
20.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
20.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
20.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
20.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
20.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
20.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
20.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
20.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
20.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
20.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
20.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
20.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
20.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
20.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
20.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
20.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensustrace-amine_onOrthosteric Ligandta1_on
19.51Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.44Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
19.23Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
19.23Single4DJHJDTic4DJH-κ-JDTic
19.23Single5TZRMK86665TZR-FFA1-MK8666
19.23Single5V57TC1145V57-SMO-TC114
19.23Single6E59L-7607356E59-NK1-L-760735
19.23Single6J20Aprepitant6J20-NK1-Aprepitant
19.23Single6J21Aprepitant6J21-NK1-Aprepitant
19.23Single6WGTLSD6WGT-5-HT2A-LSD
19.23Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
19.23Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.23Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
19.23Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
19.23Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
19.23Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
19.23Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
19.23Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.23Single9BJKNAM9BJK-μ-Naloxone-NAM
19.23Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
19.23Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
19.23Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
19.23Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.23Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
19.23Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
19.23Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
19.23Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
19.05Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
19.05Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
19.05Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
19.05Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
19.05Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
19.05Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
19.05Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
19.05Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
19.05Single8JPSCCL78JPS-ACKR1-CCL7
19.05Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
19.05Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
19.05Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
19.05Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
19.05Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
19.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
19.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
19.05Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
19.05Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
19.05Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
19.05Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
18.92Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
18.92Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.75Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.75Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
18.75Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.75Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.75Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
18.52Single4AMIBucindolol4AMI-β1-Bucindolol
18.52Single4N4WSANT-14N4W-SMO-SANT-1
18.52Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.52Single5X33BIIL2605X33-BLT1-BIIL260
18.52Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
18.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.52Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.52Single7DFPSpiperone7DFP-D2-Spiperone
18.52Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.52Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.52Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
18.52Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
18.52Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
18.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
18.52Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.52Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.52Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
18.52Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
18.52Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
18.52Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
18.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.52Single8XYIVUF106618XYI-CXCR3-VUF10661
18.52Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.52Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.52Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
18.42Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.42Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single3PBLEticlopride3PBL-D3-Eticlopride
18.18Single6HLLCP999946HLL-NK1-CP99994
18.18Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
18.18Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.18Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.18Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.18Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
18.18Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
18.18Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
18.18Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
18.18Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
18.18Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.18Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
18.18Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.18Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
18.18Single8K5BNiacin8K5B-HCA2-Niacin
18.18Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.18Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
18.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
18.18Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
18.18Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
18.18Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
18.18Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
18.18Single9B9Y7DY9B9Y-CB1-7DY
18.18Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
18.18Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.95Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.95Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
17.86Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
17.86Single6K1QIRL25006K1Q-ETB-IRL2500
17.86Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.86Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
17.86Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.86Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.86Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
17.86Single8XVJMacitentan8XVJ-ETA-Macitentan
17.86Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.86Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.86Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single6FJ3PTH6FJ3-PTH1-PTH
17.65Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.65Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.65Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.39Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
17.39Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.39Single6AKYMaraviroc6AKY-CCR5-Maraviroc
17.39Single6B73MP11046B73-κ-MP1104
17.39Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
17.39Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
17.39Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.39Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.39Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
17.39Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.39Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.39Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
17.39Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
17.39Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.39Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.39Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.39Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
17.39Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.39Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.39Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
17.39Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
17.39Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
17.39Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
17.39Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
17.39Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
17.39Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
17.39Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
17.39Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
17.39Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.39Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
17.39Single8IWESpermidine8IWE-TA9-Spermidine
17.39Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
17.39Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
17.39Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
17.39Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.39Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
17.39Single8Y0HVUF114188Y0H-CXCR3-VUF11418
17.39Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
17.39Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
17.39Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.39Single9BA0A1AKN9BA0-CB1-A1AKN
17.39Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
17.39Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
17.39Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.39Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.39Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
17.39Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
17.39Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
17.39Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.39Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.39Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.24Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
17.24Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
17.24Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.24Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
17.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.14Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
17.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
17.14Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
17.14Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.67Single3RZECidoxepin3RZE-H1-Cidoxepin
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6KUXRS-799486KUX-α2a-RS-79948
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
16.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.67Single6VI4JDTic6VI4-κ-JDTic
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
16.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.67Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
16.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
16.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.67Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
16.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
16.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
16.67Single7UL3Famotidine7UL3-H2-Famotidine
16.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
16.67Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
16.67Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
16.67Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
16.67Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
16.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
16.67Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
16.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
16.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
16.67Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensussensory_offOrthosteric Ligandopsins_off
16.67Consensusvasop-oxy_offOrthosteric Ligandot_off
16.13Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.13Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.13Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.13Single8IEBA1LYA8IEB-GPR156-A1LYA
16.00Single4DAJTiotropium4DAJ-M3-Tiotropium
16.00Single4MQSIperoxo4MQS-M2-Iperoxo
16.00Single4U14Tiotropium4U14-M3-Tiotropium
16.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
16.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
16.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
16.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
16.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
16.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.00Single6H7MSalbutamol6H7M-β1-Salbutamol
16.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
16.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
16.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
16.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
16.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
16.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
16.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
16.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
16.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
16.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
16.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.00Single8T1WCVN4248T1W-GPR6-CVN424
16.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
16.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
16.00Single8X64Desloratadine8X64-H1-Desloratadine
16.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
16.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
16.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
16.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
16.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
16.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
16.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
16.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
16.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
16.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.00Consensusblt_onOrthosteric Ligandblt1_on
16.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
16.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
16.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
16.00Consensusleukotriene_onOrthosteric Ligandblt_on
16.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
16.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
16.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
16.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.79Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.79Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.79Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.79Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
15.79Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.38Single5WIUNemonapride5WIU-D4-Nemonapride
15.38Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.38Single6HLPNetupitant6HLP-NK1-Netupitant
15.38Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.38Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
15.38Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.38Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.38Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
15.38Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.38Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.38Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.38Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.38Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
15.38Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
15.38Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
15.38Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
15.38Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.38Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.38Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.38Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.38Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.38Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
15.15Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
15.15Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
15.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
15.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
15.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.81Single4U15Tiotropium4U15-M3-Tiotropium
14.81Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.81Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.81Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.81Single6OL9Tiotropium6OL9-M5-Tiotropium
14.81Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
14.81Single7R0CAVP7R0C-V2-AVP-Arrestin2
14.81Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.81Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
14.81Single8EA0Iperoxo8EA0-M3-Iperoxo
14.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.81Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.81Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.81Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
14.81Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.81Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.81Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.81Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
14.81Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.81Consensustachykinin_offOrthosteric Ligandnk1_off
14.71Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single5CXVTiotropium5CXV-M1-Tiotropium
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.29Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.29Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
14.29Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.29Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
14.29Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
14.29Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.29Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
14.29Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.89Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.89Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
13.89Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.89Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.89Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.89Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
13.79Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.79Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.79Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.79Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
13.79Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
13.64Single3UZAGTPL92363UZA-A2A-GTPL9236
13.64Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
13.64Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.64Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.64Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.64Single6ME5Agomelatine6ME5-MT1-Agomelatine
13.64Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.64Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
13.64Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.64Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.64Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.64Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
13.64Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.64Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.51Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.51Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single5EE7MK08935EE7-Glucagon-MK0893
13.33Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.33Single8IEIA1LYA8IEI-GPR156-A1LYA
13.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.16Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
13.04Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
13.04Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
13.04Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
13.04Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
13.04Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
13.04Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.04Single6LI0C176LI0-GPR52-C17
13.04Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.04Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.04Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.04Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
13.04Single7UL2SR486927UL2-NTS1-SR48692-Na
13.04Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
13.04Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.04Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
13.04Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.04Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.04Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.04Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.04Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.04Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
13.04Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Consensusneurotensin_offOrthosteric Ligandnts1_off
13.04Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.90Single8IEIA1LYA8IEI-GPR156-A1LYA
12.90Single8IEPA1LYA8IEP-GPR156-A1LYA
12.90Single8IEPA1LYA8IEP-GPR156-A1LYA
12.90Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.82Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
12.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
12.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.50Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
12.50Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
12.50Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
12.50Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
12.50Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.50Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
12.50Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
12.50Consensusangiotensin_offOrthosteric Ligandat1_off
12.50Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
12.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
12.20Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.20Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.20Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
12.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
12.00Single6A94Zotepine6A94-5-HT2A-Zotepine
12.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
12.00Single7VV6C48/807VV6-MRGPRX2-C48/80
12.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
12.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
12.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
12.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
12.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
12.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
12.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.76Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.76Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.76Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
11.54Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
11.54Single5DSGTiotropium5DSG-M4-Tiotropium
11.54Single6IIVDaltroban6IIV-TP-Daltroban
11.54Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
11.54Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
11.54Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
11.54Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.43Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.43Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.43Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.11Single5CGCHTL142425CGC-mGlu5-HTL14242
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
11.11Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
11.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single8ZMFA1L108ZMF-5-HT2C-A1L10
11.11Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.87Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.81Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.81Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.71Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.71Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.71Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
10.71Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.71Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.53Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.34Single6IIURamatroban6IIU-TP-Ramatroban
10.34Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
10.00Single5CGDHTL142425CGD-mGlu5-HTL14242
10.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
10.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
10.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
10.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.52Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
9.52Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
9.52Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.52Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
9.52Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.09Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
9.09Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
9.09Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
9.09Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
9.09Consensussensory_onOrthosteric Ligandopsins_on
8.70Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
8.70Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.70Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.70Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.70Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
8.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.70Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.70Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.70Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.70Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
8.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
8.57Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
8.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
8.33Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
8.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
8.33Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
8.33Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
8.33Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
8.33Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
8.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.69Single7VODCariprazine7VOD-5-HT2A-Cariprazine
7.69Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.41Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.32Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
7.14Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
6.90Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.90Single7P2L4YI7P2L-mGlu5-4YI
6.90Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.90Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
6.90Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
5.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
4.76Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.76Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.76Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.55Single8HS2Fab0468HS2-GPR20-Fab046
4.55Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.35Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
4.17Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.17Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.17Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
4.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.85Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
3.85Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
3.85Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.85Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.70Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single8IYXYL-3658IYX-GPR34-YL-365
3.57Single6FFHFenobam6FFH-mGlu5-Fenobam
3.57Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
3.45Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
3.45Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.33Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.86Single7SHEPI; PE7SHE-GPR158-PI; PE

Consensus Members
Id Members
7NA7 7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
7NA8 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
Net Summary
Imin 3.11
Number of Linked Nodes 850
Number of Links 1064
Number of Hubs 167
Number of Links mediated by Hubs 643
Number of Communities 17
Number of Nodes involved in Communities 277
Number of Links involved in Communities 418
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 1307677
Length Of Smallest Path 3
Average Path Length 31.1052
Length of Longest Path 69
Minimum Path Strength 0.6525
Average Path Strength 7.0167
Maximum Path Strength 23.39
Minimum Path Correlation 0.7
Average Path Correlation 0.978699
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 41.2125
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2575
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_peptidegi_cck
gi_apelin
gi_compl-pept
gi_endothelin
gi_formylpeptide
gi_galanin
gi_ghrelin
gi_npy
gi_neurotensin
gi_opioid
gi_orexin
gi_relaxin
gi_somatostatin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_ghrelin.zip



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