Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L38 7.0525468
2A:A:K46 6.9075469
3A:A:M53 10.445448
4A:A:L195 4.2475444
5A:A:H196 5.5025413
6A:A:F197 8.57547
7A:A:R198 13.155416
8A:A:F200 11.358516
9A:A:K211 6.59714719
10A:A:W212 8.722519
11A:A:F216 9.26519
12A:A:F224 6.514509
13A:A:F251 7.046676149
14A:A:F259 7.026584
15A:A:L267 4.35754149
16A:A:F268 6.51569
17A:A:I279 4.455407
18A:A:F288 4.6156158
19A:A:Y291 11.58406
20A:A:Y297 6.77403
21A:A:Y303 14.0654156
22A:A:F308 7.00754148
23A:A:S314 4.63405
24A:A:K317 5.1975408
25A:A:Y320 11.165408
26A:A:T324 7.8975469
27A:A:D328 8.8469
28A:A:Q333 4.855445
29A:A:F336 5.42333648
30A:A:Y354 4.534505
31B:B:Q17 5.155404
32B:B:L30 6.025405
33B:B:V40 6.11254183
34B:B:L51 10.085409
35B:B:H54 8.45199
36B:B:Y59 8.37688
37B:B:W63 6.98286727
38B:B:W82 15.0675409
39B:B:D83 8.78754138
40B:B:Y85 13.445424
41B:B:N88 6.8425137
42B:B:K89 9.3575409
43B:B:H91 5.62405
44B:B:I93 7.3407
45B:B:W99 9.798519
46B:B:Y105 4.68506
47B:B:C114 4.7575408
48B:B:I123 4.6765206
49B:B:Y124 6.428506
50B:B:T128 4.50254213
51B:B:E138 5.7375406
52B:B:H142 7.7875499
53B:B:Y145 5.70857718
54B:B:F151 5.05167609
55B:B:I157 6.3525407
56B:B:D163 7.78599
57B:B:C166 3.815438
58B:B:W169 8.81833698
59B:B:F180 7.96537
60B:B:H183 8.20429739
61B:B:D186 6.1425419
62B:B:M188 5.5975418
63B:B:F199 7.004539
64B:B:C204 7.095417
65B:B:D205 7.234539
66B:B:K209 11.835436
67B:B:L210 7.624515
68B:B:W211 9.462538
69B:B:Q220 9.265417
70B:B:F222 10.8925418
71B:B:H225 10.51619
72B:B:D228 12.55419
73B:B:I232 5.8425408
74B:B:F235 8.268577106
75B:B:P236 6.0154107
76B:B:F241 9.328516
77B:B:T243 6.2625418
78B:B:D246 8.4875419
79B:B:D247 8.636519
80B:B:R251 12.7717618
81B:B:F253 9.752516
82B:B:D254 4.6125409
83B:B:D258 8.33417
84B:B:Q259 4.3406
85B:B:E260 6.54416
86B:B:Y264 5.67605
87B:B:F278 5.9954107
88B:B:R283 9.76254189
89B:B:L285 5.5925406
90B:B:Y289 6.785607
91B:B:D290 9.07406
92B:B:N295 7.1354126
93B:B:V296 2.375405
94B:B:V307 3.2645123
95B:B:H311 8.23429
96B:B:T321 5.8575407
97B:B:M325 7.748505
98B:B:W332 14.15689
99B:B:K337 8.085426
100B:B:I338 4.7525425
101B:B:W339 7.10167629
102B:B:N340 6.038529
103G:G:Y40 10.734106
104G:G:D48 5.656509
105G:G:N59 4.836529
106G:G:P60 9.5725429
107G:G:F61 6.59625828
108L:L:Y690 16.46754115
109L:L:V695 9.03754111
110L:L:C698 4.64119
111L:L:N707 5.41473
112L:L:F728 4.256509
113L:L:L738 6.2725403
114R:R:P35 3.7675474
115R:R:D37 6.9625474
116R:R:Y44 5.8445258
117R:R:F48 5.86407
118R:R:T62 4.4125407
119R:R:W74 6.338507
120R:R:Y101 7.6625405
121R:R:W102 9.8845269
122R:R:R134 7.4525409
123R:R:P141 5.1075408
124R:R:I142 5.795445
125R:R:W143 5.3725405
126R:R:R148 9.8554177
127R:R:W161 3.944509
128R:R:R175 6.735404
129R:R:K179 5.735403
130R:R:F181 8.115231
131R:R:Y182 11.3254243
132R:R:H185 7.56754241
133R:R:Y192 8.5175406
134R:R:V210 3.74404
135R:R:F212 8.8725458
136R:R:L216 7.0825456
137R:R:Y223 9.374559
138R:R:F252 8.716559
139R:R:W256 9.33658
140R:R:T262 4.3425405
141R:R:I266 4.6925474
142R:R:L276 8.0475471
143R:R:E280 7.29473
144R:R:Y291 5.266676257
145R:R:N293 7.3325459
146R:R:F308 7.055408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Y85 G:G:F61 43.232612.38YesYes248
2B:B:R68 B:B:Y85 84.55922.64NoYes054
3B:B:D83 B:B:R68 44.568715.48YesNo085
4B:B:S84 B:B:Y85 41.17897.63NoYes254
5B:B:S84 B:B:W63 41.40944.94NoYes257
6B:B:M61 B:B:W63 99.01815.82NoYes067
7B:B:C317 B:B:M61 99.41076.48NoNo076
8B:B:C317 B:B:S316 99.80333.44NoNo079
9B:B:S316 B:B:W332 1004.94NoYes099
10B:B:W63 G:G:F61 47.68225.01YesYes278
11A:A:D26 B:B:K78 12.200111.06NoNo058
12B:B:K78 B:B:P94 14.23285.02NoNo085
13B:B:I93 B:B:P94 16.26523.39YesNo075
14B:B:L79 B:B:V71 17.25364.47NoNo078
15B:B:V71 B:B:Y105 38.55745.05NoYes086
16B:B:L69 B:B:Y105 77.08724.69NoYes056
17B:B:D83 B:B:L69 39.08944.07YesNo085
18B:B:L126 B:B:V133 14.20874.47NoNo054
19B:B:L126 B:B:Y105 35.51353.52NoYes056
20B:B:Q75 B:B:W99 15.56477.67NoYes099
21B:B:Q75 B:B:Y59 15.59514.65NoYes098
22B:B:W332 B:B:Y59 49.81110.61YesYes898
23A:A:F216 B:B:W99 13.34085.01YesYes199
24A:A:H214 B:B:W332 27.66937.41NoYes889
25A:A:F259 A:A:H214 27.84026.79YesNo848
26A:A:F259 A:A:N257 61.66254.83YesNo848
27A:A:I213 A:A:N257 61.77454.25NoNo088
28A:A:I213 A:A:W212 42.94953.52NoYes089
29A:A:R209 A:A:W212 66.214511NoYes099
30A:A:L39 A:A:R209 33.03284.86NoNo099
31A:A:F224 A:A:L39 32.44636.09YesNo099
32A:A:F224 A:A:V226 38.32233.93YesNo097
33A:A:S247 A:A:V226 27.26496.46NoNo097
34A:A:A41 A:A:S247 15.17011.71NoNo079
35A:A:A41 A:A:S44 14.60831.71NoNo079
36A:A:K46 A:A:S44 13.48484.59YesNo099
37B:B:R314 B:B:W332 34.622716.99NoYes089
38A:A:F259 B:B:R314 33.94925.34YesNo048
39A:A:F216 A:A:W212 17.46296.01YesYes199
40B:B:M101 B:B:Y59 34.83714.79NoYes098
41B:B:M101 B:B:Y145 34.98225.99NoYes098
42A:A:Q205 B:B:Y145 38.259911.27NoYes198
43A:A:Q205 A:A:W212 38.309312.05NoYes199
44A:A:L250 A:A:R209 33.03388.5NoNo099
45A:A:F224 A:A:L250 32.44637.31YesNo099
46A:A:K46 A:A:L38 10.67589.87YesYes698
47A:A:D227 A:A:D230 10.04486.65NoNo088
48A:A:D230 A:A:E246 10.9997.8NoNo089
49A:A:E246 A:A:S247 11.55474.31NoNo099
50B:B:G162 B:B:Y145 13.8495.79NoYes098
51B:B:G162 B:B:S161 13.69923.71NoNo099
52A:A:K211 B:B:Y145 37.9823.58YesYes198
53A:A:K211 B:B:D246 37.52286.91YesYes199
54A:A:F260 A:A:I213 47.44285.02NoNo098
55A:A:F260 A:A:I222 47.19938.79NoNo097
56A:A:I222 A:A:I265 47.09867.36NoNo076
57A:A:F224 A:A:F251 28.953210.72YesYes099
58A:A:F308 A:A:V226 13.94710.49YesNo087
59A:A:F251 A:A:F308 14.76435.36YesYes1498
60A:A:F251 A:A:L267 12.08373.65YesYes1499
61A:A:L267 A:A:L269 10.60434.15YesNo098
62A:A:F288 A:A:L248 23.4234.87YesNo087
63A:A:F308 A:A:L248 24.43527.31YesNo087
64A:A:I265 A:A:K317 46.99894.36NoYes068
65A:A:K317 A:A:S314 52.03024.59YesYes085
66A:A:D262 A:A:N316 51.48878.08NoNo043
67A:A:N316 A:A:S314 51.62445.96NoYes035
68A:A:D262 A:A:R349 51.35283.57NoNo044
69A:A:F288 A:A:Y303 10.21246.19YesYes1586
70A:A:R349 A:A:Y354 51.21664.12NoYes045
71A:A:L348 A:A:Y354 50.39535.86NoYes085
72A:A:L348 A:A:L353 50.25766.92NoNo086
73A:A:L353 R:R:R134 47.95876.07NoYes069
74B:B:D246 B:B:S227 37.55732.94YesNo196
75B:B:S227 B:B:S245 13.32344.89NoNo169
76B:B:H225 B:B:S245 13.194111.16YesNo199
77B:B:H225 B:B:T243 25.2866.85YesYes198
78B:B:F253 B:B:T243 19.12149.08YesYes168
79B:B:F222 B:B:F253 19.865318.22YesYes186
80B:B:D258 B:B:F222 14.41559.55YesYes178
81B:B:D258 B:B:R22 12.80073.57YesNo076
82B:B:I18 B:B:R22 10.25626.26NoNo076
83B:B:D247 B:B:S227 24.12257.36YesNo196
84B:B:D247 B:B:H225 13.19496.3YesYes199
85B:B:D247 B:B:R251 10.52734.76YesYes198
86B:B:E260 B:B:R251 10.131511.63YesYes168
87B:B:D290 B:B:R314 13.204523.82YesNo068
88B:B:C271 B:B:D290 12.77116.22NoYes056
89B:B:C271 B:B:D291 12.62776.22NoNo058
90B:B:H142 B:B:S161 12.273815.34YesNo999
91B:B:H142 B:B:W169 11.70735.29YesYes998
92B:B:D66 B:B:R68 39.50423.57NoNo085
93B:B:D66 B:B:L69 39.00615.43NoNo085
94B:B:V112 B:B:V71 20.29716.41NoNo088
95B:B:L126 B:B:V112 20.29674.47NoNo058
96B:B:V112 B:B:Y124 38.5633.79NoYes086
97B:B:S122 B:B:Y124 16.25848.9NoYes086
98B:B:E138 B:B:S122 14.22687.19YesNo068
99B:B:E138 B:B:R96 12.19564.65YesNo066
100B:B:V135 B:B:Y124 16.25845.05NoYes046
101B:B:E138 B:B:V135 14.22684.28YesNo064
102B:B:E138 B:B:I120 12.19566.83YesNo066
103B:B:F241 B:B:V200 12.701917.04YesNo066
104R:R:R134 R:R:Y223 41.85269.26YesYes099
105R:R:L219 R:R:Y223 39.08724.69NoYes589
106R:R:F252 R:R:L219 39.21437.31YesNo598
107R:R:F252 R:R:W256 35.797515.03YesYes598
108R:R:W256 R:R:Y259 23.11677.72YesNo087
109R:R:Y121 R:R:Y259 23.13215.96NoNo077
110R:R:R207 R:R:Y121 24.261112.35NoNo057
111L:L:G750 R:R:R207 23.11124.5NoNo065
112L:L:G750 L:L:M747 22.91888.73NoNo064
113L:L:M747 R:R:I266 13.02255.83NoYes044
114L:L:M747 R:R:I190 10.36117.29NoNo044
115R:R:M120 R:R:W256 12.83783.49NoYes088
116R:R:M120 R:R:Y291 12.76835.99NoYes087
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Q680 R:R:F181 12.88 0 No Yes 1 1 0 1
L:L:I683 R:R:F181 11.3 23 No Yes 6 1 0 1
L:L:Y700 R:R:F181 8.25 0 No Yes 4 1 0 1
L:L:A703 R:R:F181 6.93 23 No Yes 7 1 0 1
L:L:C704 R:R:Y182 16.13 0 No Yes 1 3 0 1
L:L:N707 R:R:E280 5.26 7 Yes Yes 3 3 0 1
L:L:N707 R:R:K281 4.2 7 Yes No 3 3 0 1
L:L:D708 R:R:R33 10.72 0 No No 3 2 0 1
L:L:D708 R:R:K277 5.53 0 No No 3 2 0 1
L:L:E709 R:R:S273 4.31 0 No No 5 2 0 1
L:L:E709 R:R:K277 6.75 0 No No 5 2 0 1
L:L:R714 R:R:L30 6.07 0 No No 7 1 0 1
L:L:H744 R:R:V187 4.15 0 No No 3 1 0 1
L:L:K745 R:R:Y192 3.58 0 No Yes 4 6 0 1
L:L:D746 R:R:E280 6.5 7 No Yes 1 3 0 1
L:L:M747 R:R:I190 7.29 0 No No 4 4 0 1
L:L:M747 R:R:I266 5.83 0 No Yes 4 4 0 1
L:L:Q748 R:R:N100 14.52 0 No No 5 3 0 1
L:L:L749 R:R:L117 6.92 0 No No 8 4 0 1
L:L:L749 R:R:M120 5.65 0 No No 8 8 0 1
L:L:L749 R:R:V287 8.94 0 No No 8 5 0 1
L:L:G750 R:R:R207 4.5 0 No No 6 5 0 1
R:R:D37 R:R:P35 6.44 7 Yes Yes 4 4 2 2
R:R:K281 R:R:P35 5.02 7 No Yes 3 4 1 2
R:R:D37 R:R:K281 9.68 7 Yes No 4 3 2 1
R:R:V287 R:R:Y44 3.79 25 No Yes 5 8 1 2
R:R:Y291 R:R:Y44 4.96 25 Yes Yes 7 8 2 2
R:R:L92 R:R:Y291 4.69 0 No Yes 6 7 2 2
R:R:L117 R:R:Y121 7.03 0 No No 4 7 1 2
R:R:M120 R:R:W256 3.49 0 No Yes 8 8 1 2
R:R:M120 R:R:Y291 5.99 0 No Yes 8 7 1 2
R:R:R207 R:R:Y121 12.35 0 No No 5 7 1 2
R:R:P170 R:R:R207 4.32 0 No No 7 5 2 1
R:R:I190 R:R:R175 8.77 0 No Yes 4 4 1 2
R:R:K179 R:R:Y182 4.78 0 Yes Yes 3 3 1 1
R:R:K179 R:R:T186 4.5 0 Yes No 3 5 1 2
R:R:K179 R:R:V187 10.62 0 Yes No 3 1 1 1
R:R:E184 R:R:Y182 14.59 24 No Yes 5 3 2 1
R:R:H185 R:R:Y182 9.8 24 Yes Yes 1 3 2 1
R:R:E184 R:R:H185 7.39 24 No Yes 5 1 2 2
R:R:I190 R:R:Y192 13.3 0 No Yes 4 6 1 1
R:R:K199 R:R:Y192 5.97 0 No Yes 1 6 2 1
R:R:E200 R:R:Y192 11.22 0 No Yes 5 6 2 1
R:R:I266 R:R:L276 5.71 7 Yes Yes 4 1 1 2
R:R:E280 R:R:I266 5.47 7 Yes Yes 3 4 1 1
R:R:L276 R:R:S273 9.01 7 Yes No 1 2 2 1
R:R:E280 R:R:L276 11.93 7 Yes Yes 3 1 1 2
R:R:V287 R:R:Y291 6.31 25 No Yes 5 7 1 2
L:L:H744 R:R:G189 3.18 0 No No 3 2 0 1
L:L:V705 R:R:K179 3.04 0 No Yes 4 3 0 1
R:R:L92 R:R:T95 2.95 0 No No 6 5 2 1
L:L:D746 R:R:V187 2.92 7 No No 1 1 0 1
R:R:K277 R:R:R278 2.48 0 No No 2 1 1 2
R:R:P270 R:R:P271 1.95 0 No No 3 1 2 1
L:L:S743 R:R:P271 1.78 0 No No 3 1 0 1
R:R:G263 R:R:I266 1.76 0 No Yes 6 4 2 1
R:R:L30 R:R:P31 1.64 0 No No 1 3 1 2
L:L:Q748 R:R:T95 1.42 0 No No 5 5 0 1
R:R:D180 R:R:F181 1.19 0 No Yes 1 1 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
57.89Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
57.14Single9UYJChemerin-99UYJ-CML2-Chemerin-9-Arrestin2
56.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
52.17Consensusangiotensin_onOrthosteric Ligandat1_on
52.17Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
52.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
50.00Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
50.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
50.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
50.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
50.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
50.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
50.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
47.83Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
47.83Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
47.83Single8WSSMCH8WSS-MCH1-MCH-Gi1/β1/γ1
47.83Single9ME1CXCL129ME1-CXCR4-CXCL12
47.62Single9UYHChemerin-99UYH-CML2-Chemerin-9-Arrestin2
45.83Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
45.45Single8XQJJN2418XQJ-Apelin; Apelin-JN241
45.45Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
45.45Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
45.45Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
44.44Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.44Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.44Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
44.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
43.48Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
43.48Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
43.48Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
43.48Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.86Single6IGLIRL16206IGL-ETB-IRL1620
42.86Single6OS2TRV0266OS2-AT1-TRV026
42.86Single8XQJJN2418XQJ-Apelin; Apelin-JN241
42.86Single9L3WChemerin9L3W-CML1-Chemerin-Gi1/β1/γ2
42.31Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
41.67Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
41.67Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
41.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
41.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
40.91Consensuschemerin_onOrthosteric Ligandcml1_on
40.74Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
40.74Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
40.74Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
40.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
40.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
40.00Single9MEUCXCL129MEU-CXCR4-CXCL12
40.00Single9UYIChemerin-99UYI-CML2-Chemerin-9-Arrestin2
39.29Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
39.29Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
39.13Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
38.89Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
38.89Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
38.71Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
38.46Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
38.46Single8X8LCortistatin-148X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.46Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
38.10Single6OS1TRV0266OS1-AT1-TRV026
38.10Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
38.10Single8UGWCGS216808UGW-A2A-CGS21680
38.10Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
38.10Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
38.10Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
38.10Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
38.10Consensusrelaxin_onOrthosteric Ligandrxfp4_on
38.10Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
37.93Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
37.50Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
37.50Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
37.50Single9UMRC5a-pep9UMR-C5a1-C5a-pep-Go/β1/γ2
37.50Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
37.50Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.50Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.04Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
37.04Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
37.04Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
37.04Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
37.04Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
37.04Single8ZRTEndothelin-18ZRT-ETB-Endothelin-1
37.04Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.04Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
36.84Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
36.84Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
36.84Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
36.84Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.84Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
36.84Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
36.84Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
36.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
36.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
36.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
36.36Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
36.36Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
36.36Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
36.36Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
36.36Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
36.36Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
36.36Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
36.36Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
36.36Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
36.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
36.00Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
36.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
36.00Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
36.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
36.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.71Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
35.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.71Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
35.48Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
35.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
35.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
35.00Single7VGZRamelteon7VGZ-MT1-Ramelteon-Gi1/β1/γ2
35.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
35.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
34.78Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.78Single7EZCUK-4320977EZC-A2A-UK-432097
34.78Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
34.78Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
34.78Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
34.78Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.78Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
34.78Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
34.62Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
34.62Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.62Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.62Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
34.62Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
34.62Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.62Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
34.62Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
34.48Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
34.48Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
34.48Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6KNMJN241-96KNM-Apelin-JN241-9
33.33Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
33.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7XN9L-0545227XN9-SST2-L-054522
33.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
33.33Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
33.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
33.33Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
33.33Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
33.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
33.33Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
33.33Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
33.33Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
33.33Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
33.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusbradykinin_onOrthosteric Ligandbk2_on
33.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
33.33Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
33.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
33.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
33.33Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
33.33Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
33.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.26Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
32.26Single8ZJETAK4488ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
32.26Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
32.26Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.14Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.14Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.14Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
32.14Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
32.14Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
32.14Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
32.14Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
32.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
32.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
32.00Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
32.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
32.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
32.00Single8WDTphotoNECA8WDT-A2A-photoNECA
32.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
32.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
32.00Single8ZJDKisspeptin-18ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
32.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
32.00Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
32.00Single9MEJGp1209MEJ-CXCR4-Gp120
32.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
32.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
32.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
32.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
32.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
31.82Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
31.82Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single7XOWSulfated Gastrin-(10-17)7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
31.82Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
31.82Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
31.82Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
31.82Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
31.58Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
31.58Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.25Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
31.25Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
31.25Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.03Single4XT3CX3CL14XT3-US28-CX3CL1
31.03Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
31.03Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
31.03Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
31.03Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
31.03Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
31.03Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
30.77Single3QAKUK-4320973QAK-A2A-UK-432097
30.77Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
30.77Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
30.77Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
30.77Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
30.77Single8K6ONeuropeptide-Y8K6O-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.77Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
30.77Single9E82CXCL12 (fragment)9E82-ACKR3-CXCL12 (fragment)-Arrestin2
30.77Single9KV6TLQP219KV6-C3aB-TLQP21-Go/β1/γ2
30.77Single9L60Dynorphin9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
30.77Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.77Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
30.77Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
30.77Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.77Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.43Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
30.43Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
30.43Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
30.43Single6DRYMethylergometrine6DRY-5-HT2B-Methylergometrine
30.43Single6MXTSalmeterol6MXT-β2-Salmeterol
30.43Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
30.43Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
30.43Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8HK2C3a8HK2-C3aB-C3a-Gi1/β1/γ2
30.43Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8JJLOlodaterol8JJL-β2-Olodaterol
30.43Single8JJPChemerin-98JJP-CML2-Chemerin-9-Gi1/β1/γ2
30.43Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
30.43Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.43Single9WXMGPR15L(CT)9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
30.43Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
30.43Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
30.43Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.43Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.43Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.43Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
30.43Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
30.43Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
30.43Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
30.43Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
30.43Consensusorexin_onOrthosteric Ligandox2_on
30.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
30.00Single7EIBKallidin-des-Arg107EIB-BK1-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7F61PF-036547467F61-H3-PF-03654746
30.00Single7UL3Famotidine7UL3-H2-Famotidine
30.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
30.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
30.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
30.00Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
30.00Single9KDFRES-701-39KDF-ETB-RES-701-3
30.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.63Single3OE0CVX153OE0-CXCR4-CVX15
29.63Single5WF5UK-4320975WF5-A2A-UK-432097
29.63Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
29.63Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
29.63Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.63Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
29.63Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.63Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.63Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
29.63Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
29.17Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
29.17Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
29.17Single6IBLArformoterol6IBL-β1-Arformoterol
29.17Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.17Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
29.17Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.17Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
29.17Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
29.17Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
29.17Single7Y65C5a (C-terminal peptide)7Y65-C5a1-C5a (C-terminal peptide)-Gi1/β1/γ2
29.17Single8E0GBU728E0G-μ-BU72
29.17Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
29.17Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
29.17Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
29.17Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
29.17Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
29.17Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
29.17Single8XVUCXCL28XVU-CXCR2-CXCL2
29.17Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
29.17Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
29.17Single9KT8Acifran9KT8-HCA2-Acifran-Gi1/β1/γ2
29.17Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.17Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
29.17Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.03Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
28.57Single6D27CAY104716D27-DP2-CAY10471
28.57Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
28.57Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
28.57Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
28.57Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
28.57Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
28.57Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
28.57Single8J6PNiacin8J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
28.57Single8JHNMonomethyl fumarate8JHN-HCA2-Monomethyl fumarate-Go/β1/γ2
28.57Single8K5DGSK2560738K5D-HCA2-GSK256073
28.57Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
28.57Single8WSTMCH8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
28.57Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
28.57Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
28.57Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
28.57Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
28.57Single9CHXCarazolol9CHX-β2-Carazolol
28.57Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
28.57Single9METGp120; CD49MET-CXCR4-Gp120; CD4
28.57Consensusa3_onOrthosteric Liganda3a_on
28.57Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.57Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.57Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.57Consensushca_on_gpOrthosteric Ligandhca2_on_gp
28.57Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
28.57Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.57Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.12Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.12Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.12Consensusbombesin_onOrthosteric Ligandbb2_on
28.12Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
28.12Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
28.12Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.00Single4UG2CGS216804UG2-A2A-CGS21680
28.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
28.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
28.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
28.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
28.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
28.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
28.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
28.00Single9KZ2EP679KZ2-C3aB-EP67-Go/β1/γ2
28.00Single9KZ8EP679KZ8-C3aB-EP67-Go/β1/γ2
28.00Single9M0RNeuropeptide-VF9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
28.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
28.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
27.78Single4XNWMRS25004XNW-P2Y1-MRS2500
27.78Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.78Single6ME5Agomelatine6ME5-MT1-Agomelatine
27.78Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
27.78Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
27.78Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
27.78Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
27.59Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
27.59Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
27.59Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
27.59Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
27.59Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
27.59Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
27.59Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
27.59Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
27.59Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
27.59Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
27.59Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
27.59Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
27.59Consensuspac_onOrthosteric Ligandpac1_on
27.27Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.27Single5N2SPSB365N2S-A1-PSB36
27.27Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.27Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.27Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
27.27Single7VFXfMIFL7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
27.27Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.27Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
27.27Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
27.27Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
27.27Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
27.27Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
27.27Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.27Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
27.27Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
27.27Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.27Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
27.27Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
27.27Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
27.27Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
27.27Consensustrace-amine_onOrthosteric Ligandta1_on
26.92Single4AMJCarvedilol4AMJ-β1-Carvedilol
26.92Single4XT1CX3CL14XT1-US28-CX3CL1
26.92Single7F8XNN90567F8X-CCKA-NN9056
26.92Single7NA7Ghrelin7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
26.92Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
26.92Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
26.92Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
26.92Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
26.92Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single8XWNCXCL88XWN-CXCR2-CXCL8
26.92Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
26.92Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
26.92Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
26.92Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
26.92Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.92Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
26.92Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
26.92Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
26.67Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
26.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
26.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
26.67Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.67Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
26.67Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
26.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
26.67Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
26.47Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
26.32Single3OE9IT1t3OE9-CXCR4-IT1t
26.32Single4O9RCyclopamine4O9R-SMO-Cyclopamine
26.32Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
26.32Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
26.32Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.32Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.32Consensusgq_nucleotideOrthosteric Ligandgq_p2y
26.32Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.09Single2YDVNECA2YDV-A2A-NECA
26.09Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
26.09Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
26.09Single4UHRCGS216804UHR-A2A-CGS21680
26.09Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.09Single5G53NECA5G53-A2A-NECA-Gs
26.09Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
26.09Single6WGTLSD6WGT-5-HT2A-LSD
26.09Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.09Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
26.09Single7F1TCCL37F1T-CCR5-CCL3
26.09Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
26.09Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
26.09Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
26.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
26.09Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.09Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
26.09Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.09Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
26.09Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.09Single8HPTC5a (C-terminal peptide)8HPT-C5a1-C5a (C-terminal peptide)-Go/β1/γ2
26.09Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
26.09Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
26.09Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.09Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
26.09Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.09Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
26.09Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
26.09Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.09Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9KVPSB2901579KVP-C3aB-SB290157-Go/β1/γ2
26.09Single9L16CCL219L16-CCR7-CCL21
26.09Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.09Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.09Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.09Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.09Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
26.09Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.09Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.09Consensuslpa_onOrthosteric Ligandlpa1_on
26.09Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
26.09Consensusneurotensin_onOrthosteric Ligandnts1_on
26.09Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
26.09Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
26.09Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
25.93Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
25.93Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
25.93Single7SK5CXCL127SK5-ACKR3-CXCL12
25.93Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
25.93Single7XNACYN1548067XNA-SST2-CYN154806
25.93Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.93Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
25.93Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
25.93Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
25.93Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
25.93Single9KT7MK68929KT7-HCA2-MK6892-Gi1/β1/γ2
25.93Single9UMXEP549UMX-C5a1-EP54-Go/β1/γ2
25.93Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
25.93Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
25.81Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.81Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
25.81Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
25.71Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
25.00Single4QINSAG1.54QIN-SMO-SAG1.5
25.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
25.00Single6OBAAlprenolol6OBA-β2-Alprenolol-GTPL11074
25.00Single6PT2KGCHM076PT2-δ-KGCHM07
25.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
25.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
25.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.00Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
25.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
25.00Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
25.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
25.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
25.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
25.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
25.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
25.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
25.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.00Single8JWY2-1188JWY-A2A-2-118
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XWACXCL18XWA-CXCR2-CXCL1
25.00Single8XWMCXCL68XWM-CXCR2-CXCL6
25.00Single8XWSCXCL58XWS-CXCR2-CXCL5
25.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
25.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9KZKC3a (fragment)9KZK-C3aB-C3a (fragment)-Go/β1/γ2
25.00Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
25.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.00Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
25.00Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
25.00Single9WSVDAMGO9WSV-μ-DAMGO-Arrestin2
25.00Single9YDQDADLE9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
25.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
25.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
25.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
25.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
25.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
25.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
25.00Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
25.00Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
24.32Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
24.32Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
24.24Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
24.24Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
24.24Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
24.14Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.14Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
24.14Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
24.14Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
24.14Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
24.14Consensusapelin_onOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
24.14Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
24.14Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
24.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
24.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
24.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
24.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
24.00Single6H7LDobutamine6H7L-β1-Dobutamine
24.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
24.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
24.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
24.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
24.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
24.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
24.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
24.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
24.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
24.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
24.00Single8XGSKisspeptin-18XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
24.00Single8XWFCXCL38XWF-CXCR2-CXCL3
24.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
24.00Single8ZPLHF511168ZPL-CXCR4-HF51116
24.00Single9HYIDP819HYI-5-HT1A-DP81-Gi1/β1/γ2
24.00Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
24.00Single9KUGEP679KUG-C5a1-EP67-Go/β1/γ2
24.00Single9KV8TLQP219KV8-C3aB-TLQP21-Go/β1/γ2
24.00Single9M54Neuropeptide-VF9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
24.00Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
24.00Single9VI9RFRP-39VI9-NPFF1-RFRP-3-Gi1/β1/γ2
24.00Single9YDPDADLE9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
24.00Single9YDRDADLE9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
24.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
24.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single4LDOEpinephrine4LDO-β2-Epinephrine
23.81Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
23.81Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
23.81Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
23.81Single6KUXRS799486KUX-α2a-RS79948
23.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.81Single6MH8ZM-2413856MH8-A2A-ZM-241385
23.81Single6PS0Carazolol6PS0-β2-Carazolol
23.81Single6PS4ICI118-5516PS4-β2-ICI118-551
23.81Single6PS5Propranolol6PS5-β2-Propranolol
23.81Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.81Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
23.81Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
23.81Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
23.81Single7T32ZM-2413857T32-A2A-ZM-241385
23.81Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
23.81Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
23.81Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GE5Constrained Epinephrine8GE5-β2-Constrained Epinephrine-Gs/β1/γ1
23.81Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
23.81Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
23.81Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
23.81Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
23.81Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
23.81Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
23.81Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
23.81Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
23.81Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.81Single8GURCP559408GUR-CB2-CP55940-Gi1/β1/γ2
23.81Single8IHKAcifran8IHK-HCA3-Acifran
23.81Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.81Single8JEIPubChem 117155568JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
23.81Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
23.81Single8JIMMonomethyl fumarate8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2
23.81Single8K4NPubChem 1687197658K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
23.81Single8K9KDAMGO8K9K-μ-DAMGO-Gi3/β1/γ1
23.81Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.81Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.81Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
23.81Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
23.81Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
23.81Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
23.81Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
23.81Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
23.81Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
23.81Single9L84Epinephrine9L84-β1-Epinephrine-Atazanavir-Gs/β1/γ2
23.81Single9P1TZM-2413859P1T-A2A-ZM-241385
23.81Single9VNFPindolol9VNF-5-HT1A-Pindolol-Go/β1/γ2
23.81Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
23.81Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
23.81Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Consensushca_onOrthosteric Ligandhca2_on
23.53Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
23.53Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
23.53Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
23.53Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
23.53Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
23.53Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
23.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
23.33Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
23.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
23.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
23.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.33Consensuscalcitonin_onOrthosteric Ligandctlike_on
23.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.33Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
23.33Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
23.08Single3NY9PubChem 9131033NY9-β2-PubChem 913103
23.08Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
23.08Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
23.08Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.08Single8XZFWN5618XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
23.08Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
23.08Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
23.08Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.08Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
23.08Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
23.08Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
22.86Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
22.86Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
22.86Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
22.73Single2Y02Carmoterol2Y02-β1-Carmoterol
22.73Single2Y04Salbutamol2Y04-β1-Salbutamol
22.73Single3EMLZM-2413853EML-A2A-ZM-241385
22.73Single3NY8ICI118-5513NY8-β2-ICI118-551
22.73Single3ZPQPubChem 5945903ZPQ-β1-PubChem 594590-Na
22.73Single4EJ4Naltrindole4EJ4-δ-Naltrindole
22.73Single4GBRCarazolol4GBR-β2-Carazolol
22.73Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
22.73Single4QIMANTA XV4QIM-SMO-ANTA XV
22.73Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
22.73Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
22.73Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
22.73Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
22.73Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
22.73Single6H7MSalbutamol6H7M-β1-Salbutamol
22.73Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
22.73Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
22.73Single6PS2Alprenolol6PS2-β2-Alprenolol
22.73Single6S0LZM-2413856S0L-A2A-ZM-241385
22.73Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
22.73Single7BTSEpinephrine7BTS-β1-Epinephrine
22.73Single7BU6Norepinephrine7BU6-β1-Norepinephrine
22.73Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
22.73Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
22.73Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
22.73Single7JOZPubChem 752020227JOZ-D1-PubChem 75202022-Gs/β1/γ2
22.73Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
22.73Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
22.73Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
22.73Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
22.73Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.73Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.73Single7XJHIsoprenaline7XJH-β3-Isoprenaline-Gs/β1/γ2
22.73Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.73Single8EFQDAMGO8EFQ-μ-DAMGO-Gi1/β1/γ2
22.73Single8GE2Constrained Epinephrine8GE2-β2-Constrained Epinephrine-Gs/β1/γ1
22.73Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
22.73Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
22.73Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
22.73Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
22.73Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
22.73Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
22.73Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.73Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
22.73Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
22.73Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
22.73Single8JIINiacin8JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
22.73Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
22.73Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
22.73Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
22.73Single8ZQEGPR15L(CT)8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
22.73Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
22.73Single9P1SZM-2413859P1S-A2A-ZM-241385
22.73Single9VMYTMU41429VMY-5-HT1A-TMU4142-Go/β1/γ2
22.73Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
22.73Consensus5ht5_onOrthosteric Ligand5ht5a_on
22.73Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.73Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
22.73Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
22.73Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
22.73Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
22.73Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.73Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
22.73Consensusdopamine_offOrthosteric Ligandd2_off d3_off
22.73Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
22.73Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
22.73Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
22.73Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
22.73Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
22.73Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
22.58Single6FJ3PTH6FJ3-PTH1-PTH
22.58Single6P9YPACAP276P9Y-PAC1-PACAP27-Gs/β1/γ2
22.58Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
22.58Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
22.58Single7SK3CXCL127SK3-ACKR3-CXCL12
22.58Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
22.58Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
22.58Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.58Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
22.58Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
22.58Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
22.58Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
22.22Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
22.22Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.22Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
22.22Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
22.22Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
22.22Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
22.22Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
22.22Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
22.22Single8XBHPubChem 1626566368XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
22.22Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
22.22Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
22.22Single9UYLChemerin-99UYL-CML2-Chemerin-9-Arrestin2
22.22Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
22.22Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
22.22Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
22.22Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusp2y_offOrthosteric Ligandp2y1_off
22.22Consensussomatostatin_offOrthosteric Ligandsst2_off
21.88Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
21.88Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
21.88Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.88Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
21.88Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
21.88Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
21.88Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
21.88Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
21.88Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
21.88Consensusglp_onOrthosteric Ligandglp1_on glp2_on
21.88Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
21.74Single2RH1Carazolol2RH1-β2-Carazolol
21.74Single2Y00Dobutamine2Y00-β1-Dobutamine
21.74Single2Y03Isoprenaline2Y03-β1-Isoprenaline
21.74Single2YCWCarazolol2YCW-β1-Carazolol
21.74Single4JKVTaladegib4JKV-SMO-Taladegib
21.74Single5C1MBU725C1M-μ-BU72
21.74Single5D6LCarazolol5D6L-β2-Carazolol
21.74Single5IUAQ274563485IUA-A2A-Q27456348-Na
21.74Single5JQHCarazolol5JQH-β2-Carazolol
21.74Single5N2RPSB365N2R-A2A-PSB36-Na
21.74Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
21.74Single5TVNLSD5TVN-5-HT2B-LSD
21.74Single5WIUNemonapride5WIU-D4-Nemonapride
21.74Single5WIVNemonapride5WIV-D4-Nemonapride-Na
21.74Single5X7DCarazolol5X7D-β2-Carazolol-PubChem 129318963
21.74Single6E67BI1671076E67-β2-BI167107-Gs(CT)
21.74Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
21.74Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
21.74Single6PS3Carvedilol6PS3-β2-Carvedilol
21.74Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.74Single6S0QZM-2413856S0Q-A2A-ZM-241385
21.74Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
21.74Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
21.74Single7BVQCarazolol7BVQ-β1-Carazolol
21.74Single7C61Ergotamine7C61-5-HT1B-Ergotamine
21.74Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
21.74Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
21.74Single7EPFNAM5977EPF-mGlu2-NAM597
21.74Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
21.74Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
21.74Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.74Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
21.74Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
21.74Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
21.74Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
21.74Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
21.74Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
21.74Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
21.74Single8IZ4Lysophosphatidylserine (TJR)8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
21.74Single8QOTNanobody-E8QOT-μ-Nanobody-E
21.74Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
21.74Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
21.74Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
21.74Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
21.74Single9EHSLUF76029EHS-A3A-LUF7602
21.74Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
21.74Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
21.74Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
21.74Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
21.74Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
21.74Single9IYBPGD29IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
21.74Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
21.74Single9KUVCMPD6449KUV-Apelin-CMPD644-Arrestin2
21.74Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
21.74Single9VJFBuspirone9VJF-5-HT1A-Buspirone-Gi3/β1/γ2
21.74Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
21.74Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
21.74Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.74Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
21.74Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
21.74Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
21.74Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
21.74Consensusamine_offonOrthosteric Ligandamine_off amine_on
21.74Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
21.74Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
21.74Consensusbeta2_offOrthosteric Ligand2RH1-β2-Carazolol 6PS3-β2-Carvedilol 6PS5-β2-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-PubChem 913103 6PRZ-β2-Alprenolol
21.74Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
21.74Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.74Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.74Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.74Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.74Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.74Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.74Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.74Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
21.62Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.62Consensuspth_onOrthosteric Ligandpth1_on pth2_on
21.43Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
21.43Single9IK8Pasireotide9IK8-SST1-Pasireotide-Gi1/β1/γ2
21.43Single9JFK(Pen5)-Urotensin II9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.43Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
21.43Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
21.43Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
21.21Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
21.21Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
21.21Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
21.21Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
21.21Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
21.21Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
21.21Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
21.21Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.21Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.21Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
21.05Single3OE6IT1t3OE6-CXCR4-IT1t
21.05Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
21.05Single6PWCNeurotensin-(9-13)6PWC-NTS1-Neurotensin-(9-13)-Arrestin2
21.05Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
21.05Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.05Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
21.05Single8JPSCCL78JPS-ACKR1-CCL7
21.05Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
21.05Single9IJRC179IJR-GPR52-C17-Arrestin2
20.93Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.83Single3P0GBI1671073P0G-β2-BI167107
20.83Single3PDSFAUC503PDS-β2-FAUC50
20.83Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
20.83Single4LDLHydroxybenzyl Isoproterenol4LDL-β2-Hydroxybenzyl Isoproterenol
20.83Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.83Single5D5ACarazolol5D5A-β2-Carazolol
20.83Single5D5BCarazolol5D5B-β2-Carazolol
20.83Single5V56TC1145V56-SMO-TC114
20.83Single5V57TC1145V57-SMO-TC114
20.83Single5XR8AM120335XR8-CB1-AM12033
20.83Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
20.83Single6DDEDAMGO6DDE-μ-DAMGO-Gi1/β1/γ2
20.83Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.83Single6J21Aprepitant6J21-NK1-Aprepitant
20.83Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.83Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
20.83Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.83Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
20.83Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
20.83Single7M8W15r-Methyl-PGD27M8W-DP2-15r-Methyl-PGD2-Na
20.83Single7PX4PSB-21137PX4-A2A-PSB-2113
20.83Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.83Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.83Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
20.83Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
20.83Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
20.83Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
20.83Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
20.83Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
20.83Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
20.83Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.83Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
20.83Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
20.83Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
20.83Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
20.83Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
20.83Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
20.83Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
20.83Single8WU1MDMB-Fubinaca8WU1-CB1-MDMB-Fubinaca-Arrestin2
20.83Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.83Single9B65MDMB-Fubinaca9B65-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.83Single9BS9LSD9BS9-D2-LSD
20.83Single9BSBLSD9BSB-D2-LSD-chim(NtGi1-Go)/β1/γ2
20.83Single9I54PubChem 1764520919I54-D1-PubChem 176452091-Gs/β1/γ2
20.83Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9WSTDAMGO9WST-μ-DAMGO-chim(NtGi1-Gz)/β1/γ2
20.83Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
20.83Consensusa2_onOrthosteric Liganda2b_on
20.83Consensusa2_on_gpOrthosteric Liganda2b_on_gp
20.83Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.83Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.83Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
20.83Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-PubChem 594590-Na 3ZPR-β1-PubChem 598754-Na
20.83Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.83Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.83Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.83Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.83Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
20.83Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.83Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.83Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.69Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
20.69Single6VN7PACAP276VN7-VPAC1-PACAP27-Gs/β1/γ2
20.69Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.69Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.69Single8XZGApelin-138XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
20.69Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
20.69Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.69Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
20.69Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
20.69Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
20.69Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.69Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.51Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
20.51Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
20.51Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
20.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.00Single3D4STimolol3D4S-β2-Timolol
20.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.00Single4LDEBI1671074LDE-β2-BI167107
20.00Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
20.00Single5L7IVismodegib5L7I-SMO-Vismodegib
20.00Single6H7NXamoterol6H7N-β1-Xamoterol
20.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
20.00Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
20.00Single6METGp160; CD46MET-CCR5-Gp160; CD4
20.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
20.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.00Single7EO4Siponimod7EO4-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
20.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
20.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
20.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
20.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
20.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
20.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
20.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
20.00Single8FYTLSD8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8ID9Icosapent8ID9-FFA4-Icosapent-Gi1/β1/γ2
20.00Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
20.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
20.00Single8JJ8Arformoterol8JJ8-β2-Arformoterol
20.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
20.00Single8JWZEtrumadenant8JWZ-A2A-Etrumadenant-Na
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
20.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
20.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.00Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
20.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
20.00Single9DGIZ85267113509DGI-CB1-Z8526711350
20.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
20.00Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
20.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
20.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
20.00Single9KVG5-MeO-DMT9KVG-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
20.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
20.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
20.00Single9U9VMETH9U9V-β2-METH-Gs/β1/γ2
20.00Single9V6ONalfurafine9V6O-κ-Nalfurafine-Gi1/β1/γ2
20.00Single9VJ6F-155999VJ6-5-HT1A-F-15599-Gi3/β1/γ2
20.00Single9WSWEndomorphin9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
20.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
20.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
20.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
20.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
20.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
20.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.00Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
20.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
20.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
20.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.51Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
19.44Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
19.44Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
19.44Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
19.44Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
19.44Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
19.44Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.35Single5YQZNNC17025YQZ-Glucagon-NNC1702
19.35Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
19.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.35Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.35Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
19.23Single6DDFDAMGO6DDF-μ-DAMGO-Gi1/β1/γ2
19.23Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
19.23Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
19.23Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
19.23Single7UM4AS26747237UM4-5-HT5A-AS2674723
19.23Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
19.23Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
19.23Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
19.23Single8GAGZ85267113508GAG-CB1-Z8526711350-Gi1/β1/γ2
19.23Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
19.23Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
19.23Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
19.23Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
19.23Single8XBES3E-Lysophosphatidylserine 8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
19.23Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
19.23Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
19.23Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
19.23Single9J0BUDP-Glucose9J0B-P2Y14-UDP-Glucose-Gi1/β1/γ2
19.23Single9L79AR2314539L79-GPR119-AR231453-chim(NtGi1-Gs)/β1/γ2
19.23Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
19.23Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.23Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
19.23Consensusendothelin_offOrthosteric Ligandetb_off
19.23Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
19.23Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
19.23Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
19.23Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
19.05Single3ODUIT1t3ODU-CXCR4-IT1t
19.05Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
19.05Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
19.05Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
19.05Single5OLVLUAA470705OLV-A2A-LUAA47070-Na
19.05Single6AKXA4R6AKX-CCR5-A4R
19.05Single6AKYMaraviroc6AKY-CCR5-Maraviroc
19.05Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
19.05Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
19.05Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
19.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
19.05Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
19.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
19.05Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
19.05Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
19.05Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
19.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
19.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
19.05Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
19.05Single8FYXBuspirone8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1
19.05Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
19.05Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
19.05Single8IW4Spermidine8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
19.05Single8IWESpermidine8IWE-TAA9-Spermidine
19.05Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
19.05Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
19.05Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
19.05Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8YNFCXCL88YNF-ACKR1-CXCL8
19.05Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
19.05Single8Z87CHBA8Z87-HCA1-CHBA-Gi1/β1/γ2
19.05Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
19.05Single9H2XPubChem 1756706449H2X-A2A-PubChem 175670644-Na
19.05Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
19.05Single9JKXAcifran9JKX-HCA3-Acifran-Gi1/β1/γ2
19.05Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
19.05Single9KO6CCL199KO6-CCR7-CCL19
19.05Single9VJ5Gepirone9VJ5-5-HT1A-Gepirone-Go/β1/γ2
19.05Single9VJEBuspirone9VJE-5-HT1A-Buspirone-Go/β1/γ2
19.05Single9W49U-50488H9W49-κ-U-50488H-Gi1/β1/γ2
19.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
19.05Consensusalpha2_offOrthosteric Ligandalpha2c_off
19.05Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
19.05Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
18.92Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
18.92Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
18.92Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
18.92Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
18.92Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
18.75Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
18.75Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
18.75Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.75Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
18.75Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.60Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
18.52Single5VBLAMG3054 5VBL-Apelin-AMG3054
18.52Single5ZTYAM102575ZTY-CB2-AM10257
18.52Single6PT3DPI-2876PT3-δ-DPI-287
18.52Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
18.52Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
18.52Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.52Single7SK9CCX6627SK9-ACKR3-CCX662
18.52Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
18.52Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
18.52Single8SAILysophosphatidylserine (S12)8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
18.52Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
18.52Single8X5YAstemizole8X5Y-H1-Astemizole
18.52Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
18.52Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
18.52Single9MD1Buspirone9MD1-5-HT1A-Buspirone-PtdIns4P-Gz/β1/γ2
18.52Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.42Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
18.18Single2YDOAdenosine2YDO-A2A-Adenosine
18.18Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.18Single4MBSMaraviroc4MBS-CCR5-Maraviroc
18.18Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
18.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.18Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.18Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.18Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.18Single5JTBZM-2413855JTB-A2A-ZM-241385
18.18Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.18Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.18Single5UVIZM-2413855UVI-A2A-ZM-241385
18.18Single6A94Zotepine6A94-5-HT2A-Zotepine
18.18Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
18.18Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
18.18Single6VI4JDTic6VI4-κ-JDTic
18.18Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.18Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
18.18Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
18.18Single7AROLUF58337ARO-A2A-LUF5833-Na
18.18Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
18.18Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
18.18Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
18.18Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
18.18Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
18.18Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
18.18Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
18.18Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.18Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
18.18Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.18Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
18.18Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
18.18Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
18.18Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
18.18Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
18.18Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
18.18Single8K5CAcipimox8K5C-HCA2-Acipimox
18.18Single8K9LDAMGO8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
18.18Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
18.18Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
18.18Single8THKA-616038THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
18.18Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.18Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
18.18Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
18.18Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
18.18Single8ZPMAMD0708ZPM-CXCR4-AMD070
18.18Single9AS5Mescaline9AS5-5-HT2A-Mescaline
18.18Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
18.18Single9JH3CMF-0199JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
18.18Single9L8LBI1671079L8L-β2-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
18.18Single9LL8Psilocin9LL8-5-HT2A-Psilocin-Gi1/β1/γ2
18.18Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
18.18Single9PXVNaloxone9PXV-μ-Naloxone-Gi1/β1/γ2
18.18Single9VJG8-OH-DPAT9VJG-5-HT1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
18.18Single9W6W5-CT9W6W-5-HT5A-5-CT-Gi1/β1/γ2
18.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
18.18Consensusa2_offOrthosteric Liganda2a_off
18.18Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA47070-Na 5N2R-A2A-PSB36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-Etrumadenant-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-PubChem 984073-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
18.18Consensusalpha1_onOrthosteric Ligandalpha1a_on
18.18Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
18.18Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.18Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
18.18Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
17.86Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.86Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
17.86Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
17.86Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
17.86Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.86Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
17.86Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
17.86Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
17.86Single9M4TSilodosin9M4T-Alpha1A-Silodosin
17.86Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.65Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
17.65Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
17.65Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
17.39Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
17.39Single2Y01Dobutamine2Y01-β1-Dobutamine
17.39Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
17.39Single3NYAAlprenolol3NYA-β2-Alprenolol
17.39Single3ZPRPubChem 5987543ZPR-β1-PubChem 598754-Na
17.39Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
17.39Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.39Single5DHHSB-6121115DHH-NOP-SB-612111
17.39Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.39Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.39Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.39Single5UIGPubChem 1240811965UIG-A2A-PubChem 124081196
17.39Single5ZKPSR274175ZKP-PAF-SR27417
17.39Single6DRXLisuride6DRX-5-HT2B-Lisuride
17.39Single6KPFAM120336KPF-CB2-AM12033-Gi1/β1/γ2
17.39Single6PRZAlprenolol6PRZ-β2-Alprenolol
17.39Single6PS1Timolol6PS1-β2-Timolol
17.39Single6TOTLemborexant6TOT-OX1-Lemborexant
17.39Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
17.39Single7BU7BI1671077BU7-β1-BI167107
17.39Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.39Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
17.39Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.39Single7LJCSKF812977LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
17.39Single7NA8Ibutamoren7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
17.39Single7PYRPSB-21157PYR-A2A-PSB-2115
17.39Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
17.39Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
17.39Single7UL4Alvimopan7UL4-μ-Alvimopan
17.39Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
17.39Single7V3ZCP559407V3Z-CB1-CP55940
17.39Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
17.39Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
17.39Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
17.39Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
17.39Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
17.39Single8CU6LJ-45178CU6-A2A-LJ-4517
17.39Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
17.39Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
17.39Single8JJOAlprenolol8JJO-β2-Alprenolol
17.39Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
17.39Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
17.39Single8JXRLSD8JXR-D1-LSD
17.39Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
17.39Single8T1WCVN4248T1W-GPR6-CVN424
17.39Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
17.39Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
17.39Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
17.39Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
17.39Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
17.39Single8XBGS3E-Lysophosphatidylserine 8XBG-GPR34-S3E-Lysophosphatidylserine
17.39Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
17.39Single8Y71A1D6F8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
17.39Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
17.39Single8ZYYNeurotensin-(8-13)8ZYY-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
17.39Single9AS1DMT9AS1-5-HT2A-DMT
17.39Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
17.39Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
17.39Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
17.39Single9DYFAsenapine9DYF-5-HT1A-Asenapine-PtdIns4P-Gi1/β1/γ2
17.39Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
17.39Single9H37PubChem 1756706469H37-A2A-PubChem 175670646-Na
17.39Single9IYAONO-97105319IYA-GPR55-ONO-9710531
17.39Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
17.39Single9KFTfMLFC9KFT-FPR1-ALX-fMLFC-Gi1/β1/γ2
17.39Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
17.39Single9PLNPubChem 1682595949PLN-α2a-PubChem 168259594
17.39Single9PLOPubChem 1682595949PLO-α2a-PubChem 168259594-Go/β1/γ2
17.39Single9PQDPubChem 1764919279PQD-α2a-PubChem 176491927
17.39Single9UAZAtropine9UAZ-M1-Atropine
17.39Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.39Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.39Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
17.39Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
17.39Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
17.39Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
17.39Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
17.39Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Consensusblt_onOrthosteric Ligandblt1_on
17.39Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
17.39Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Consensusleukotriene_onOrthosteric Ligandblt_on
17.39Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
17.24Single6HLOAprepitant6HLO-NK1-Aprepitant
17.24Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
17.24Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
17.24Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
17.24Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
17.24Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.14Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
17.14Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
17.07Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
16.67Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
16.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
16.67Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
16.67Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
16.67Single6KPCAM120336KPC-CB2-AM12033
16.67Single6PS6Timolol6PS6-β2-Timolol
16.67Single7C4SS1P7C4S-S1P3-S1P
16.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7WC6LSD7WC6-5-HT2A-LSD
16.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
16.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
16.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
16.67Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
16.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
16.67Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
16.67Single8JXSPF-61428JXS-D1-PF-6142
16.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Single8PWNTheophylline8PWN-A2A-Theophylline
16.67Single8S4DCMF-0198S4D-Apelin-CMF-019
16.67Single8TF5Oleic acid8TF5-GPR6-Oleic acid
16.67Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
16.67Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
16.67Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
16.67Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
16.67Single8ZMFPubChem 1719206738ZMF-5-HT2C-PubChem 171920673
16.67Single8ZRKGSK12922638ZRK-GPR119-GSK1292263-Gs/β1/γ2
16.67Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9B54VIP369B54-CB1-VIP36-Gi1/β1/γ2
16.67Single9DYDAsenapine9DYD-5-HT1A-Asenapine-PtdIns4P-Go/β1/γ2
16.67Single9JKSPubChem 442501769JKS-HCA3-PubChem 44250176-Gi1/β1/γ2
16.67Single9KT6Acifran9KT6-HCA3-Acifran-Gi1/β1/γ2
16.67Single9L74S1P d16:19L74-S1P3-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single9PXYNaloxone9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
16.67Single9U81Tolvaptan9U81-V2-Tolvaptan
16.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
16.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
16.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
16.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
16.67Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
16.67Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
16.22Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.13Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
16.13Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
16.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
16.00Single4DJHJDTic4DJH-κ-JDTic
16.00Single4U15Tiotropium4U15-M3-Tiotropium
16.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.00Single5XRAAM115425XRA-CB1-AM11542
16.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
16.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
16.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.00Single6OL9Tiotropium6OL9-M5-Tiotropium
16.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
16.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
16.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
16.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
16.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
16.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
16.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
16.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
16.00Single8XBIPubChem 1626566368XBI-GPR34-PubChem 162656636
16.00Single8XVLZibotentan8XVL-ETA-Zibotentan
16.00Single8XZICMF-0198XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
16.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
16.00Single8ZWFJR14a8ZWF-C3aB-JR14a
16.00Single9BJKNaloxone9BJK-μ-Naloxone-PubChem 171642066
16.00Single9EGOZ85267113509EGO-CB1-Z8526711350-Gi1/β1/γ2
16.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
16.00Single9IK9Lanreotide9IK9-SST1-Lanreotide-Gi1/β1/γ2
16.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
16.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
16.00Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
16.00Single9RHGC4079RHG-FZD7-C407
16.00Single9YDVMRS29059YDV-P2Y14-MRS2905-Gi1/β1/γ2
16.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
16.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-methyl-Scopolamine 5ZHP-M3-PubChem 134828589
16.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
16.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
16.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.79Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.79Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.79Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.79Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
15.79Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.79Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.79Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8IWM2-Phenylethylamine8IWM-TAA9-2-Phenylethylamine
15.79Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
15.79Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
15.79Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8Z8ALactate8Z8A-HCA1-Lactate-Gi1/β1/γ2
15.79Single9CHUNorepinephrine9CHU-β2-Norepinephrine
15.79Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
15.79Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
15.79Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
15.62Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
15.62Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
15.62Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
15.62Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
15.38Single4N4WSANT-14N4W-SMO-SANT-1
15.38Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.38Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.38Single5CXVTiotropium5CXV-M1-Tiotropium
15.38Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
15.38Single6A93Risperidone6A93-5-HT2A-Risperidone
15.38Single6KQICP559406KQI-CB1-CP55940-Org27569
15.38Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.38Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
15.38Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.38Single7DFPSpiperone7DFP-D2-Spiperone
15.38Single7EPENAM5637EPE-mGlu2-NAM563
15.38Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
15.38Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
15.38Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
15.38Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
15.38Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
15.38Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
15.38Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.38Single7YITNalfurafine7YIT-κ-Nalfurafine
15.38Single8WRBLysophosphatidylserine (UBL)8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
15.38Single8XYIVUF106618XYI-CXCR3-VUF10661
15.38Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
15.38Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
15.38Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.38Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.38Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
15.38Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
15.38Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
15.38Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
15.38Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
15.38Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.15Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
15.15Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
15.15Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
15.15Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
15.15Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
15.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
15.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
15.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
15.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
15.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
15.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8IW72-Phenylethylamine8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
15.00Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
15.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
15.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
15.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
15.00Single9KT93,5-DHBA9KT9-HCA1-3,5-DHBA-Gi1/β1/γ2
15.00Single9LRCHistamine9LRC-H4-Histamine
15.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
15.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
15.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
15.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
15.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.81Single5X93K-87945X93-ETB-K-8794
14.81Single6K1QIRL25006K1Q-ETB-IRL2500
14.81Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.81Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
14.81Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.81Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
14.81Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8WRZAM8418WRZ-CB1-AM841-Arrestin2
14.81Single8XVJMacitentan8XVJ-ETA-Macitentan
14.81Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
14.81Single9DYEBuspirone9DYE-5-HT1A-Buspirone-PtdIns4P-Go/β1/γ2
14.81Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
14.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
14.71Single6P9XCorticoliberin-16P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
14.71Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.71Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
14.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
14.71Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
14.71Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
14.71Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
14.29Single3PBLEticlopride3PBL-D3-Eticlopride
14.29Single6HLLCP999946HLL-NK1-CP99994
14.29Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
14.29Single6LI0C176LI0-GPR52-C17
14.29Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
14.29Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
14.29Single7SRQLSD7SRQ-5-HT2B-LSD
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
14.29Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
14.29Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
14.29Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
14.29Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
14.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
14.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
14.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
14.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
14.29Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
14.29Single8KGGLysophosphatidylserine (WJS)8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
14.29Single8W892-Phenylethylamine8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
14.29Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
14.29Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
14.29Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
14.29Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
14.29Single8ZYUNeurotensin-(8-13)8ZYU-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
14.29Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9B9YTaranabant9B9Y-CB1-Taranabant
14.29Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
14.29Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
14.29Single9IPYJR14a9IPY-C3aB-JR14a
14.29Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
14.29Single9JEDHistamine9JED-H4-Histamine-PO4-Gi1/β1/γ2
14.29Single9JEQHistamine9JEQ-H3-Histamine-Gi1/β1/γ2
14.29Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
14.29Single9L42Histamine9L42-H4-Histamine-Gi1/β1/γ2
14.29Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
14.29Single9WSXEndomorphin9WSX-μ-Endomorphin-Arrestin2
14.29Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
14.29Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.29Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
14.29Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.89Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.89Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.79Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
13.79Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
13.79Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
13.79Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
13.79Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
13.79Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
13.79Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
13.79Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
13.64Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.64Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.64Single3PWHZM-2413853PWH-A2A-ZM-241385
13.64Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
13.64Single5U09Taranabant5U09-CB1-Taranabant
13.64Single5ZKQABT-4915ZKQ-PAF-ABT-491
13.64Single6B73MP11046B73-κ-MP1104
13.64Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.64Single6DS0LY2660976DS0-5-HT2B-LY266097
13.64Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.64Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.64Single6TODEMPA6TOD-OX1-EMPA-Na
13.64Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.64Single7EJ0Norepinephrine7EJ0-α2a-Norepinephrine-Go/β1/γ2
13.64Single7F8ULintitript7F8U-CCKA-Lintitript
13.64Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
13.64Single7T6STC-FPR 437T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2
13.64Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.64Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
13.64Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
13.64Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.64Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.64Single7XRRLemborexant7XRR-OX2-Lemborexant
13.64Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
13.64Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.64Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
13.64Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
13.64Single8TZQDopamine8TZQ-D2-Dopamine-Go/β1/γ2
13.64Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
13.64Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
13.64Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
13.64Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
13.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
13.64Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
13.64Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.64Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
13.64Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
13.64Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.64Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
13.64Single9KVHCinobufotenine9KVH-5-HT1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
13.64Single9LL9DOI9LL9-5-HT2A-DOI-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single9LLBDOI-NBOMe9LLB-5-HT2A-DOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
13.64Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
13.64Single9PXUNaloxone9PXU-μ-Naloxone-Na
13.64Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
13.64Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Consensusangiotensin_offOrthosteric Ligandat1_off
13.64Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.64Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.64Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
13.64Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
13.64Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Consensusorexin_offOrthosteric Ligandox2_off ox1_off
13.64Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
13.64Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
13.64Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.64Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
13.64Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
13.64Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.64Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.51Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
13.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.04Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.04Single3REYPubChem 56973REY-A2A-PubChem 5697
13.04Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
13.04Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.04Single4ZJCSB-6740424ZJC-OX1-SB-674042
13.04Single6AQFZM-2413856AQF-A2A-ZM-241385
13.04Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
13.04Single6TPGEMPA6TPG-OX2-EMPA
13.04Single6TPNHTL66416TPN-OX2-HTL6641
13.04Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.04Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.04Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.04Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.04Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
13.04Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
13.04Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.04Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.04Single7VV6C48/807VV6-MRGPRX2-C48/80
13.04Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
13.04Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8PM2DMCHA8PM2-TA7-DMCHA-Gs/β1/γ2
13.04Single8RLNLUF58348RLN-A2A-LUF5834
13.04Single8U02Dopamine8U02-D2-Dopamine-Go/β1/γ2
13.04Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.04Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
13.04Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
13.04Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
13.04Single8ZBWQuin-C18ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
13.04Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
13.04Single8ZPNAMD31008ZPN-CXCR4-AMD3100
13.04Single9ARXSerotonin9ARX-5-HT2A-Serotonin
13.04Single9AS3LSD9AS3-5-HT2A-LSD
13.04Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9AS8Psilocin9AS8-5-HT2A-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single9BA0MRI-18919BA0-CB1-MRI-1891
13.04Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.04Single9JKYAcifran9JKY-HCA2-Acifran-Gi1/β1/γ2
13.04Single9K1DButyric acid9K1D-FFA2-Butyric acid-Gi1/β1/γ2
13.04Single9KPDSalicin9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
13.04Single9KVIBufotenin9KVI-5-HT1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
13.04Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
13.04Single9ODJMitragynine Pseudoindoxyl9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
13.04Single9ODLMitragynine Pseudoindoxyl9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
13.04Single9PXXNaloxone9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
13.04Single9PY2Loperamide9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
13.04Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
13.04Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
13.04Consensusgrh_offOrthosteric Ligandgnrh1_off
13.04Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
12.90Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
12.90Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
12.90Single9B5YLA-PTH Analog9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
12.50Single4DAJTiotropium4DAJ-M3-Tiotropium
12.50Single4MQSIperoxo4MQS-M2-Iperoxo
12.50Single4U14Tiotropium4U14-M3-Tiotropium
12.50Single4U16N-methyl-Scopolamine4U16-M3-N-methyl-Scopolamine
12.50Single4YAYZD-71554YAY-AT1-ZD-7155
12.50Single5DHGC-355DHG-NOP-C-35
12.50Single5DSGTiotropium5DSG-M4-Tiotropium
12.50Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
12.50Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
12.50Single5TGZAM65385TGZ-CB1-AM6538
12.50Single5UENDU1725UEN-A1-DU172
12.50Single5YC8N-methyl-Scopolamine5YC8-M2-N-methyl-Scopolamine
12.50Single5ZK8N-methyl-Scopolamine5ZK8-M2-N-methyl-Scopolamine
12.50Single5ZKCN-methyl-Scopolamine5ZKC-M2-N-methyl-Scopolamine
12.50Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
12.50Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.50Single6NIYCalcitonin-16NIY-CT-Calcitonin-1-Gs/β1/γ2
12.50Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
12.50Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
12.50Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
12.50Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
12.50Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
12.50Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
12.50Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
12.50Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.50Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
12.50Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
12.50Single8X63Mepyramine8X63-H1-Mepyramine
12.50Single8X64Desloratadine8X64-H1-Desloratadine
12.50Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.50Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.50Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
12.50Single9IMATalquetamab9IMA-GPRC5D; GPRC5D-Talquetamab
12.50Single9JEAAtropine9JEA-M1-Atropine
12.50Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
12.50Single9LLAAriadne9LLA-5-HT2A-Ariadne-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single9PXWNaloxone9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
12.50Consensusalpha2_onOrthosteric Ligandalpha2b_on
12.50Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
12.50Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.50Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.50Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.50Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.50Consensushistamine_offOrthosteric Ligandh1_off
12.50Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.50Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.50Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
12.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
12.00Single5WQCEMPA5WQC-OX2-EMPA
12.00Single5XPRBosentan5XPR-ETB-Bosentan
12.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.00Single6TP6Filorexant6TP6-OX1-Filorexant
12.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.00Single7W41PD1762527W41-BB2-PD176252
12.00Single7WIGL-0542647WIG-SST2-L-054264-Gi1/β1/γ2
12.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
12.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
12.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
12.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
12.00Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
12.00Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
12.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
12.00Single9B9ZMRI-18679B9Z-CB1-MRI-1867
12.00Single9HAPTolvaptan9HAP-V2-Tolvaptan
12.00Single9KPFSalicin9KPF-TAS2R16-Salicin-Gi1/β1/γ2
12.00Single9KUTJR14a9KUT-C3aB-JR14a-Go/β1/γ2
12.00Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
12.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
12.00Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
12.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.00Consensusbombesin_offOrthosteric Ligandbb2_off
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
12.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
12.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
11.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
11.54Single5TZRMK86665TZR-FFA1-MK8666
11.54Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.54Single6J20Aprepitant6J20-NK1-Aprepitant
11.54Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.54Single6TQ7SB-3348676TQ7-OX1-SB-334867
11.54Single7EW4CYM-55417EW4-S1P3-CYM-5541-Gi1/β1/γ2
11.54Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
11.54Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
11.54Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
11.54Single7U2LC5-guano7U2L-μ-C5-guano-Gi1/β1/γ2
11.54Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
11.54Single8EA0Iperoxo8EA0-M3-Iperoxo
11.54Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
11.54Single8I9LC3a8I9L-C3aB-C3a-Go/β1/γ2
11.54Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.54Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
11.54Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
11.54Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single9PY3Loperamide9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
11.54Single9PY4Loperamide9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
11.54Single9UCPIperoxo9UCP-M1-Iperoxo-G11(CT)
11.54Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.54Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.54Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.54Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
11.54Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
11.54Consensustachykinin_offOrthosteric Ligandnk1_off
11.43Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
11.43Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
11.11Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.11Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.11Single6CM4Risperidone6CM4-D2-Risperidone
11.11Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.11Single7K15MKD0467K15-BLT1-MKD046-Na
11.11Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
11.11Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.11Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
11.11Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
11.11Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
11.11Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
11.11Single9CM3TUG-13759CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single9EK0Iperoxo9EK0-M5-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9YDUUDP-Glucose9YDU-P2Y14-UDP-Glucose-Gi1/β1/γ2
11.11Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
10.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.71Single7D7MPGE27D7M-EP4-PGE2-Gs/β1/γ1
10.71Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
10.71Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
10.71Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9M1HPGE29M1H-EP1-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
10.71Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
10.71Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7WC4Serotonin7WC4-5-HT2A-Serotonin
10.53Single7XKEDehydroepiandrosterone7XKE-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
10.53Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.53Single9JIDNiacin9JID-HCA3-Niacin-Gi1/β1/γ2
10.34Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
10.34Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.34Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
10.34Single9JF4PD1683689JF4-BB1-PD168368
10.34Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9NS9TUG-13759NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
10.00Single3OE8IT1t3OE8-CXCR4-IT1t
10.00Single3RFMCaffeine3RFM-A2A-Caffeine
10.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
10.00Single8WKYPG-9348WKY-MC4-PG-934
10.00Single9M42A1L8O9M42-GPR139-A1L8O-chim(Gs-CtGq)/β1/γ2
10.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
10.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
10.00Consensussensory_onOrthosteric Ligandopsins_on
9.68Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
9.68Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
9.68Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.52Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.52Single3UZAGTPL92363UZA-A2A-GTPL9236
9.52Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.52Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
9.52Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
9.52Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.52Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
9.52Single7WC5Psilocin7WC5-5-HT2A-Psilocin
9.52Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single8ITFDMCHA8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
9.52Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.52Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
9.52Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
9.52Single9JG1Adriforant9JG1-H4-Adriforant
9.52Single9JKT(2R)-2-hydroxy-3-phenylpropanoic acid9JKT-HCA3-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
9.52Single9LL7DOI9LL7-5-HT2A-DOI-Gi1/β1/γ2
9.52Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
9.52Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.52Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
9.38Single6W25SHU91196W25-MC4-SHU9119-Ca
9.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.38Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
9.09Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.09Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.09Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.09Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
9.09Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
9.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.09Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.09Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.09Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2
9.09Single7UL2SR486927UL2-NTS1-SR48692-Na
9.09Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
9.09Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
9.09Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
9.09Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single9AS7Psilocin9AS7-5-HT2A-Psilocin
9.09Single9EPRAll-trans-Retinal9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
9.09Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
9.09Single9JLCAVE 09919JLC-MAS1-AVE 0991-Gi1/β1/γ2
9.09Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
9.09Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
9.09Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
9.09Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.09Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Consensusneurotensin_offOrthosteric Ligandnts1_off
9.09Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.82Single7XV3Lysophosphatidylserine (WJS)7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
8.70Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
8.70Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.70Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
8.70Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
8.70Single5WS3EMPA5WS3-OX2-EMPA
8.70Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
8.70Single7BR3Elagolix7BR3-GnRH1-Elagolix
8.70Single7F8YDevazepide7F8Y-CCKA-Devazepide
8.70Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
8.70Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
8.70Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
8.70Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.70Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.70Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
8.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
8.70Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
8.70Single8Y0HVUF114188Y0H-CXCR3-VUF11418
8.70Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
8.70Single9K6LSalicin9K6L-TAS2R16-Salicin-Gi2/β1/γ2
8.70Single9KPESalicin9KPE-TAS2R16-Salicin-Gi1/β1/γ2
8.70Single9LKDPL459LKD-OR5V1-PL45
8.70Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
8.70Single9PEEPF-07054894; OXM29PEE-CCR6-PF-07054894; OXM2
8.70Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
8.70Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
8.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.33Single3RZECidoxepin3RZE-H1-Cidoxepin
8.33Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
8.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
8.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
8.33Single6IQLL7458706IQL-D4-L745870
8.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
8.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
8.33Single6V9SGTPL114036V9S-OX1-GTPL11403
8.33Single6ZINSR486926ZIN-NTS1-SR48692
8.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
8.33Single8K2WAMG4878K2W-CXCR3-AMG487
8.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
8.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.33Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9LKBPL459LKB-OR5V1-PL45-chim(NtGi1-Gs)/β1
8.33Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
8.33Single9W33S5A19W33-SST5-S5A1
8.33Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
8.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
8.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
8.33Consensussensory_offOrthosteric Ligandopsins_off
8.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
8.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.00Single6GPSMK08126GPS-CCR2-MK0812
8.00Single6IIVDaltroban6IIV-TXA2-Daltroban
8.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
8.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.00Single8GCML-9026888GCM-EP4-L-902688-Gi1/β1/γ2
8.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
8.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
8.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
8.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
8.00Single9JQZGrapiprant 9JQZ-EP4-Grapiprant
8.00Consensuscck_offOrthosteric Ligandccka_off
8.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
7.69Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
7.69Single5CGCHTL142425CGC-mGlu5-HTL14242
7.69Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
7.69Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
7.69Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
7.69Single6GPXMK08126GPX-CCR2-MK0812
7.69Single6HLPNetupitant6HLP-NK1-Netupitant
7.69Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
7.69Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
7.69Single6Z4SSR486926Z4S-NTS1-SR48692
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
7.69Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
7.69Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.69Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
7.69Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
7.69Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
7.69Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9EKHONO-30302979EKH-DP1-ONO-3030297
7.69Single9HC04YI9HC0-mGlu5-4YI
7.69Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
7.69Consensusblt_offOrthosteric Ligandblt1_off
7.69Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
7.69Consensusep_offOrthosteric Ligandep4_off
7.41Single6E59L-7607356E59-NK1-L-760735
7.41Single7P2L4YI7P2L-mGlu5-4YI
7.41Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.41Single8X0FVU298X0F-mGlu5; mGlu5-Quisqualate-VU29
7.41Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
7.41Single9AS9RS130-1809AS9-5-HT2A-RS130-180
7.41Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9E9SPGD29E9S-DP1-PGD2-Gs/β1/γ1
7.41Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.14Single6AK3PGE26AK3-EP3-PGE2
7.14Single6IIURamatroban6IIU-TXA2-Ramatroban
7.14Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.14Single8DWCBAM8-228DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.14Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
7.14Single9BJKPubChem 1716420669BJK-μ-Naloxone-PubChem 171642066
7.14Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.14Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.90Single5CGDHTL142425CGD-mGlu5-HTL14242
6.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.67Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.45Single8DWGBAM8-228DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.45Single8IZBLysophosphatidylserine (UBL)8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
6.25Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.25Single6D35Cholesterol6D35-SMO-Cholesterol
6.25Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
6.25Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
6.25Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
6.25Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
6.25Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
6.25Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
6.25Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
6.25Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
6.25Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
6.25Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
6.25Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
6.25Single7DTTCa7DTT-CaS; CaS-Ca-Ca
6.25Single7DTTCa7DTT-CaS; CaS-Ca-Ca
6.25Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
6.25Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
6.25Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
6.25Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
6.25Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
6.25Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
6.25Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.25Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.25Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
6.25Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
6.25Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
6.25Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
6.25Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
6.25Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
6.25Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
6.25Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
6.25Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
6.25Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
6.25Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
6.25Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
6.25Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
6.25Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
6.25Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
6.25Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
6.25Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
6.25Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
6.25Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
6.25Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
6.25Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
6.25Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
6.25Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
6.25Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
6.25Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
6.25Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
6.25Single7XW7K1-707XW7-TSH-K1-70
6.25Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.25Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
6.25Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
6.25Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
6.25Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
6.25Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
6.25Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
6.25Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
6.25Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
6.25Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
6.25Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
6.25Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
6.25Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
6.25Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
6.25Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
6.25Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
6.25Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
6.25Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
6.25Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
6.25Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
6.25Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
6.25Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
6.25Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.25Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.25Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
6.25Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.25Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
6.25Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
6.25Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
6.25Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
6.25Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.25Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.25Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
6.25Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
6.25Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
6.25Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
6.25Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
6.25Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
6.25Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
6.25Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
6.25Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
6.25Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
6.25Single8WG9PubChem 1793948WG9-mGlu4; mGlu2-PubChem 179394
6.25Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
6.25Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
6.25Single8WGCLY3792688WGC-mGlu2; mGlu4-LY379268
6.25Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
6.25Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8WVXNorrin8WVX-LGR4-Norrin
6.25Single8WVYNorrin8WVY-LGR4-Norrin
6.25Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
6.25Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
6.25Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
6.25Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
6.25Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
6.25Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
6.25Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
6.25Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
6.25Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
6.25Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
6.25Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
6.25Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
6.25Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
6.25Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
6.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
6.25Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
6.25Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
6.25Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.25Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.25Single9KB7R-spondin-29KB7-LGR4-R-spondin-2
6.25Single9KGKNB189KGK-LGR4-NB18
6.25Single9KHHNorrin9KHH-LGR4-Norrin
6.25Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
6.25Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
6.25Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
6.25Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
6.25Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
6.25Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
6.25Single9S37NB219S37-LGR4-NB21
6.25Single9S38NB219S38-LGR4-NB21
6.25Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.88Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.88Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.88Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.88Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
5.56Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.56Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
5.56Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.26Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
5.26Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
5.26Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.26Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.26Single7UTZTSH7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
5.26Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.26Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.26Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.00Single5L7DCholesterol5L7D-SMO-Cholesterol
5.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.00Single7XKDDehydroepiandrosterone7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
5.00Single8I2GFSH8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.76Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.76Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
4.76Single8Y02All-trans-Retinal8Y02-OPN1SW-All-trans-Retinal-Gi1/β1/γ2
4.76Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.76Single9L0HJR14a9L0H-C3aB-JR14a-Go/β1/γ2
4.55Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.55Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.55Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.55Single8IU2All-trans-Retinal8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
4.55Single8J6QPubChem 251012238J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
4.55Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
4.55Consensusgi_sensoryOrthosteric Ligandgi_opsins
4.55Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
4.55Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
4.35Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.35Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.35Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
4.35Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.35Single6TP4ACT-4622066TP4-OX1-ACT-462206
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
4.35Single7XKFDehydroepiandrosterone7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
4.35Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
4.35Single8J6PPubChem 251012238J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
4.35Single8JHYPubChem 251012238JHY-HCA2-PubChem 25101223-Gi1/β1/γ2
4.35Single8JIIPubChem 251012238JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
4.35Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9MBCAZ122160529MBC-mGlu8; mGlu8-DCPG-AZ12216052
4.35Single9MNIdC2_059MNI-CTLike-dC2_05-RAMP1
4.35Single9YDAAll-trans-Retinal9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
4.17Single4S0VSuvorexant4S0V-OX2-Suvorexant
4.17Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.17Single6TPJSuvorexant6TPJ-OX2-Suvorexant
4.17Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
4.17Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.17Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
4.17Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
4.17Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
4.17Single8DWGML3828DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8T3VDoconexent8T3V-FFA1-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.00Single6FFIMPEP6FFI-mGlu5-MPEP
4.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
4.00Single6TPKRetosiban6TPK-OT-Retosiban
4.00Single8IYXYL-3658IYX-GPR34-YL-365
4.00Single8Y01All-trans-Retinal8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
4.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9KXSEP679KXS-C5a1-EP67-Go/β1/γ2
4.00Single9U80Conivaptan9U80-V2-Conivaptan
4.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
4.00Consensusvasop-oxy_offOrthosteric Ligandot_off
3.85Single6FFHFenobam6FFH-mGlu5-Fenobam
3.85Single7F83PF-051904577F83-Ghrelin-PF-05190457
3.85Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
3.85Single9JROPF-044189489JRO-EP2-PF-04418948
3.85Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
3.85Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
3.70Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
3.70Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.70Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
3.70Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
3.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.70Single9EE5ONO-25502899EE5-DP1-ONO-2550289
3.70Single9JRTTG6-1299JRT-EP2-TG6-129
3.57Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.57Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
3.57Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
3.57Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.57Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.57Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
3.45Single5X33BIIL2605X33-BLT1-BIIL260
3.45Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
3.45Single9W32SSTR5 antagonist 19W32-SST5-SSTR5 antagonist 1
3.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
3.23Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.23Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.12Single8KIGSHU91198KIG-MC3-SHU9119-Ca
3.12Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
3.12Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.12Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
3.03Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
3.03Single9KB8R-spondin-29KB8-LGR4-R-spondin-2-ZNRF3; ZNRF3
3.03Single9KB9R-spondin-29KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
2.94Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.94Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
2.94Single9KB9R-spondin-29KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3

PDB Summary
PDB 9KX6
Class A
SubFamily Peptide
Type Complement Peptide
SubType C5A1
Species Mus Musculus
Ligand C5a-des-Arg
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.11
Date 2025-11-26
D.O.I. 10.1101/2025.05.26.656101
Net Summary
Imin 3.44
Number of Linked Nodes 907
Number of Links 1036
Number of Hubs 146
Number of Links mediated by Hubs 552
Number of Communities 26
Number of Nodes involved in Communities 179
Number of Links involved in Communities 241
Path Summary
Number Of Nodes in MetaPath 117
Number Of Links MetaPath 116
Number of Shortest Paths 1555993
Length Of Smallest Path 3
Average Path Length 28.6598
Length of Longest Path 57
Minimum Path Strength 1.345
Average Path Strength 6.99033
Maximum Path Strength 25.32
Minimum Path Correlation 0.7
Average Path Correlation 0.986615
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 48.2594
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.8225
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Anaphylotoxins (complement system)
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Anaphylotoxins (complement system)
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>9KX6_Chain_A
LSAEERAAL ERSKAIEKN LKEDGISAA KDVKLLLLG ASGKSTIVK 
QMKIGIVET HFTFKNLHF RLFDVGGQR SERKKWIHC FEDVTAIIF 
CVLSMHESL MLFDSICNN KFFIDTSII LFLNKKDLF GEKIKKSPL 
TICFPEYTG PNTYEDAAA YIQAQFESK NRSPNKEIY CHMTCATDT 
NNQVFDAVT DIIIANNLR GCGLYDNDD AI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9KX6_Chain_B
QLRQEAEQL KNQIRDARK ACADATLSQ ITNNIDPVG RIQMRTRRT 
LRGHLAKIY AMHWGTDSR LLVSASQDG KLIIWDSYT TNKVHAIPL 
RSSWVMTCA YAPSGNYVA CGGLDNICS IYNLKTREG NVRVSRELA 
GHTGYLSCC RFLDDNQIV TSSGDTTCA LWDIETGQQ TTTFTGHTG 
DVMSLSLAP DTRLFVSGA CDASAKLWD VREGMCRQT FTGHESDIN 
AICFFPNGN AFATGSDDA TCRLFDLRA DQELMTYSH DNIICGITS 
VSFSKSGRL LLAGYDDFN CNVWDALKA DRAGVLAGH DNRVSCLGV 
TDDGMAVAT GSWDSFLKI WN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9KX6_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinC5a-des-Arg
UniProtP01031
Sequence
>9KX6_Chain_L
TLQKKIEEI AAKYKHSVV KKCCYDGAC VNNDETCEQ RAARISLGP 
RCIKAFTEC CVVASQLRA NISHKDMQL G


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30993
Sequence
>9KX6_Chain_R
PADGIHLPK RQPGDVAAL IIYSVVFLV GVPGNALVV WVTAFEARR 
AVNAIWFLN LAVADLLSC LALPVLFTT VLNHNYWYF DATACIVLP 
SLILLNMYA SILLLATIS ADRFLLVFK PIWCQKVRG TGLAWMACG 
VAWVLALLL TIPSFVYRE AYKDFYSEH TVCGINYGG GSFPKEKAV 
AILRLMVGF VLPLLTLNI CYTFLLLRT WSRKATRST KTLKVVMAV 
VICFFIFWL PYQVTGVMI AWLPPSSPT LKRVEKLNS LCVSLAYIN 
CCVNPIIYV MAGQGFHGR LLRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5O9HAPeptideComplement PeptideC5a1Homo sapiens-NDT9513727-2.72018-01-10doi.org/10.1038/nature25025
6C1QAPeptideComplement PeptideC5a1Homo sapiensPMX53NDT9513727-2.92018-05-30doi.org/10.1038/s41594-018-0067-z
6C1RAPeptideComplement PeptideC5a1Homo sapiensPMX53Avacopan; Na-2.22018-05-30doi.org/10.1038/s41594-018-0067-z
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y64 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-Gi1/β1/γ23.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-3.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensBM213-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC089 peptide-2.82023-03-01doi.org/10.1038/s41422-023-00779-2
8HK5APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ232023-05-10doi.org/10.1038/s41589-023-01339-w
8HK5 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-32023-05-10doi.org/10.1038/s41589-023-01339-w
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-Go/β1/γ23.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HPT (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-3.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQC (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-Go/β1/γ23.312023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZ (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-3.312023-10-18doi.org/10.1016/j.cell.2023.09.020
9KWGAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9KWG (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.152025-11-2610.1101/2025.05.26.656101
9KWXAPeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.132025-11-2610.1101/2025.05.26.656101
9KWX (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.132025-11-2610.1101/2025.05.26.656101
9KX6 (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.112025-11-2610.1101/2025.05.26.656101
9KXSAPeptideComplement PeptideC5a1Mus musculusEP67-Go/β1/γ23.312025-11-2610.1101/2025.05.26.656101
9KXS (No Gprot) APeptideComplement PeptideC5a1Mus musculusEP67-3.312025-11-2610.1101/2025.05.26.656101
9UMRAPeptideComplement PeptideC5a1Homo sapiensC5a-pep-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9UMR (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-pep-3.152025-11-2610.1101/2025.05.26.656101
9UMXAPeptideComplement PeptideC5a1Homo sapiensEP54-Go/β1/γ23.22025-11-2610.1101/2025.05.26.656101
9UMX (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP54-3.22025-11-2610.1101/2025.05.26.656101
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.542025-01-15To be published
8JZP (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.542025-01-15To be published
9KUGAPeptideComplement PeptideC5a1Homo sapiensEP67-Go/β1/γ23.072025-11-2610.1101/2025.05.26.656101
9KUG (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP67-3.072025-11-2610.1101/2025.05.26.656101




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KX6.zip



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