psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K686	L:L:L683	7.05	No	No	2	2	4
2	L:L:I742	L:L:L683	11.42	No	No	2	3	4
3	L:L:E745	L:L:L683	3.98	No	No	0	1	4
4	L:L:R684	R:R:Y178	7.2	No	No	0	1	1
5	L:L:R684	R:R:D180	13.1	No	No	0	1	1
6	L:L:E689	L:L:K686	6.75	No	No	0	2	2
7	L:L:I742	L:L:K686	5.82	No	No	2	3	2
8	L:L:I687	R:R:F181	10.05	No	Yes	0	7	1
9	L:L:E734	L:L:Q690	16.57	Yes	No	2	3	3
10	L:L:I738	L:L:Q690	8.23	No	No	2	3	3
11	L:L:C703	L:L:Y694	8.06	No	Yes	2	9	5
12	L:L:E734	L:L:Y694	5.61	Yes	Yes	2	3	5
13	L:L:C735	L:L:Y694	6.72	No	Yes	2	9	5
14	L:L:H696	L:L:V698	5.54	Yes	Yes	2	4	1
15	L:L:H696	L:L:P699	7.63	Yes	Yes	2	4	1
16	L:L:H696	L:L:L727	7.71	Yes	Yes	2	4	1
17	L:L:P699	L:L:V698	3.53	Yes	Yes	2	1	1
18	L:L:L727	L:L:V698	4.47	Yes	Yes	2	1	1
19	L:L:L727	L:L:P699	4.93	Yes	Yes	2	1	1
20	L:L:A731	L:L:P699	3.74	No	Yes	0	6	1
21	L:L:K700	L:L:Y704	4.78	No	Yes	0	4	3
22	L:L:K701	R:R:P24	3.35	No	No	0	1	3
23	L:L:C702	L:L:C728	7.28	No	No	2	9	8
24	L:L:C703	L:L:C735	7.28	No	No	2	9	9
25	L:L:D705	R:R:D26	6.65	No	Yes	0	3	3
26	L:L:F732	L:L:G706	6.02	Yes	No	0	8	9
27	L:L:N710	L:L:R708	22.9	No	Yes	3	7	1
28	L:L:E713	L:L:R708	5.82	Yes	Yes	3	5	1
29	L:L:R708	L:L:R718	13.86	Yes	Yes	3	1	8
30	L:L:F732	L:L:R708	6.41	Yes	Yes	3	8	1
31	L:L:F711	L:L:V709	7.87	Yes	No	4	3	4
32	L:L:R743	L:L:V709	9.15	No	No	0	6	4
33	L:L:V709	R:R:Y182	23.97	No	Yes	4	4	3
34	L:L:E713	L:L:N710	13.15	Yes	No	3	5	7
35	L:L:N710	L:L:R718	6.03	No	Yes	3	7	8
36	L:L:F711	L:L:Y712	9.28	Yes	No	0	3	2
37	L:L:F711	L:L:K749	7.44	Yes	No	4	3	4
38	L:L:F711	L:L:P750	10.11	Yes	No	4	3	1
39	L:L:F711	R:R:Y182	15.47	Yes	Yes	4	3	3
40	L:L:F711	R:R:V187	3.93	Yes	No	4	3	1
41	L:L:Y712	R:R:K32	9.55	No	No	0	2	4
42	L:L:E713	L:L:E717	5.07	Yes	No	0	5	3
43	L:L:E713	L:L:R718	11.63	Yes	Yes	3	5	8
44	L:L:E713	R:R:L30	5.3	Yes	No	3	5	1
45	L:L:E716	L:L:T714	5.64	No	No	0	3	7
46	L:L:C715	L:L:C736	7.28	No	Yes	3	9	9
47	L:L:E716	L:L:E717	6.34	No	No	0	3	3
48	L:L:F732	L:L:R718	6.41	Yes	Yes	3	8	8
49	L:L:R718	R:R:D26	3.57	Yes	Yes	0	8	3
50	L:L:R718	R:R:L30	7.29	Yes	No	3	8	1
51	L:L:I729	L:L:V719	3.07	No	No	0	4	6
52	L:L:F732	L:L:V719	5.24	Yes	No	0	8	6
53	L:L:R721	L:L:T723	9.06	No	No	0	8	2
54	L:L:R721	R:R:I28	8.77	No	No	0	8	4
55	L:L:I729	L:L:V722	7.68	No	No	0	4	4
56	L:L:G725	L:L:P726	4.06	No	No	0	1	1
57	L:L:L727	L:L:P726	4.93	Yes	No	0	1	1
58	L:L:C736	L:L:F732	6.98	Yes	Yes	3	9	8
59	L:L:N733	L:L:T737	2.92	No	Yes	0	1	3
60	L:L:C735	L:L:E734	3.04	No	Yes	2	9	3
61	L:L:E734	L:L:I738	8.2	Yes	No	2	3	3
62	L:L:E745	L:L:K744	4.05	No	No	0	1	2
63	L:L:E745	L:L:S746	10.06	No	No	0	1	3
64	L:L:K749	L:L:P747	8.36	No	No	0	4	3
65	L:L:H748	R:R:E176	4.92	No	No	0	5	3
66	L:L:H748	R:R:G189	3.18	No	No	0	5	2
67	L:L:K749	L:L:P750	5.02	No	No	4	4	1
68	L:L:P750	R:R:V187	10.6	No	No	4	1	1
69	L:L:V751	R:R:R175	6.54	No	Yes	1	3	4
70	L:L:V751	R:R:I190	4.61	No	No	1	3	4
71	L:L:Q752	R:R:V96	2.87	No	Yes	1	4	5
72	L:L:Q752	R:R:N100	11.88	No	No	0	4	3
73	L:L:Q752	R:R:S284	8.66	No	No	1	4	4
74	L:L:L753	R:R:L92	2.77	Yes	Yes	1	8	6
75	L:L:L753	R:R:W102	5.69	Yes	Yes	1	8	9
76	L:L:L753	R:R:P113	8.21	Yes	No	0	8	5
77	L:L:L753	R:R:I116	2.85	Yes	Yes	1	8	6
78	L:L:R755	R:R:R175	3.2	Yes	Yes	0	9	4
79	L:L:R755	R:R:Y259	12.35	Yes	Yes	0	9	7
80	L:L:R755	R:R:T262	5.17	Yes	No	0	9	5
81	L:L:R755	R:R:G263	6	Yes	No	0	9	6
82	L:L:R755	R:R:N283	7.23	Yes	No	0	9	4
83	R:R:A25	R:R:H29	2.93	No	No	0	5	3
84	R:R:D26	R:R:G27	5.03	Yes	No	0	3	5
85	R:R:D26	R:R:H29	17.65	Yes	No	0	3	3
86	R:R:H99	R:R:K32	15.72	No	No	0	4	4
87	R:R:P35	R:R:R33	2.88	Yes	No	0	4	2
88	R:R:Q34	R:R:V38	5.73	No	No	0	4	6
89	R:R:H99	R:R:Q34	7.42	No	No	0	4	4
90	R:R:P35	R:R:V38	3.53	Yes	No	0	4	6
91	R:R:K281	R:R:P35	5.02	No	Yes	0	3	4
92	R:R:D37	R:R:K281	4.15	No	No	0	4	3
93	R:R:D37	R:R:L282	14.93	No	No	0	4	5
94	R:R:D37	R:R:L285	5.43	No	No	0	4	6
95	R:R:A40	R:R:S288	3.42	No	Yes	0	5	5
96	R:R:F93	R:R:L41	7.31	No	No	0	7	4
97	R:R:L41	R:R:V96	2.98	No	Yes	0	4	5
98	R:R:L41	R:R:L97	8.3	No	No	0	4	3
99	R:R:I43	R:R:S288	12.39	No	Yes	0	5	5
100	R:R:I292	R:R:I43	2.94	No	No	0	6	5
101	R:R:L89	R:R:Y44	5.86	No	Yes	1	8	8
102	R:R:L92	R:R:Y44	4.69	Yes	Yes	1	6	8
103	R:R:V96	R:R:Y44	3.79	Yes	Yes	1	5	8
104	R:R:S288	R:R:Y44	3.82	Yes	Yes	0	5	8
105	R:R:Y291	R:R:Y44	2.98	Yes	Yes	1	7	8
106	R:R:L89	R:R:V47	2.98	No	No	0	8	8
107	R:R:C295	R:R:V47	10.25	No	No	0	8	8
108	R:R:F48	R:R:L49	3.65	No	No	0	7	6
109	R:R:F48	R:R:V52	6.55	No	No	0	7	6
110	R:R:F48	R:R:P90	7.22	No	No	0	7	8
111	R:R:C295	R:R:V50	3.42	No	No	0	8	6
112	R:R:P53	R:R:V52	3.53	No	No	0	4	6
113	R:R:L87	R:R:V52	2.98	No	No	0	5	6
114	R:R:G54	R:R:L57	5.13	No	No	0	8	6
115	R:R:D82	R:R:N55	18.85	Yes	No	9	9	9
116	R:R:L83	R:R:N55	2.75	No	No	0	8	9
117	R:R:N55	R:R:P298	13.03	No	No	9	9	9
118	R:R:L312	R:R:L57	6.92	No	No	8	6	6
119	R:R:A79	R:R:V58	3.39	No	No	0	9	9
120	R:R:V58	R:R:Y301	5.05	No	Yes	0	9	9
121	R:R:V59	R:R:V80	3.21	No	No	0	7	6
122	R:R:F308	R:R:V61	5.24	Yes	No	0	8	7
123	R:R:S315	R:R:V61	3.23	No	No	0	6	7
124	R:R:L76	R:R:T62	2.95	No	No	0	5	7
125	R:R:T62	R:R:Y301	6.24	No	Yes	0	7	9
126	R:R:F64	R:R:R67	4.28	No	Yes	0	5	5
127	R:R:E65	R:R:S315	7.19	No	No	0	5	6
128	R:R:I73	R:R:R67	6.26	Yes	Yes	5	6	5
129	R:R:R67	R:R:T150	5.17	Yes	Yes	5	5	1
130	R:R:R67	R:R:W154	7	Yes	Yes	5	5	4
131	R:R:R148	R:R:V70	15.69	Yes	No	0	7	6
132	R:R:N71	R:R:R148	9.64	No	Yes	0	8	7
133	R:R:I73	R:R:T150	4.56	Yes	Yes	5	6	1
134	R:R:A153	R:R:I73	6.5	No	Yes	0	8	6
135	R:R:I73	R:R:W154	19.97	Yes	Yes	5	6	4
136	R:R:T129	R:R:W74	3.64	No	Yes	0	7	7
137	R:R:I130	R:R:W74	5.87	Yes	Yes	0	9	7
138	R:R:D133	R:R:W74	18.98	No	Yes	0	8	7
139	R:R:A153	R:R:W74	5.19	No	Yes	0	8	7
140	R:R:F75	R:R:Y301	20.63	No	Yes	0	8	9
141	R:R:L126	R:R:N77	5.49	Yes	Yes	5	8	9
142	R:R:N77	R:R:W154	5.65	Yes	Yes	5	9	4
143	R:R:C157	R:R:N77	12.6	No	Yes	5	8	9
144	R:R:N77	R:R:W161	5.65	Yes	Yes	5	9	9
145	R:R:L78	R:R:S123	3	No	No	0	9	9
146	R:R:I130	R:R:L78	2.85	Yes	No	0	9	9
147	R:R:C86	R:R:D82	4.67	No	Yes	0	7	9
148	R:R:C294	R:R:D82	7.78	No	Yes	0	9	9
149	R:R:D82	R:R:P298	4.83	Yes	No	9	9	9
150	R:R:L83	R:R:L87	2.77	No	No	0	8	5
151	R:R:L84	R:R:N119	13.73	No	No	0	7	8
152	R:R:N119	R:R:S85	4.47	No	No	0	8	7
153	R:R:S85	R:R:Y291	6.36	No	Yes	0	7	7
154	R:R:A88	R:R:I116	3.25	No	Yes	0	7	6
155	R:R:L89	R:R:Y291	3.52	No	Yes	1	8	7
156	R:R:L112	R:R:V91	4.47	No	No	0	5	6
157	R:R:I116	R:R:L92	2.85	Yes	Yes	1	6	6
158	R:R:L92	R:R:Y291	4.69	Yes	Yes	1	6	7
159	R:R:S284	R:R:V96	3.23	No	Yes	1	4	5
160	R:R:N98	R:R:Y103	15.12	No	No	0	4	3
161	R:R:Y101	R:R:Y103	31.77	No	No	0	5	3
162	R:R:H185	R:R:Y101	15.24	No	No	0	1	5
163	R:R:T186	R:R:Y101	11.24	No	No	0	5	5
164	R:R:F104	R:R:W102	13.03	No	Yes	0	8	9
165	R:R:C109	R:R:W102	5.22	No	Yes	1	9	9
166	R:R:C188	R:R:W102	7.84	No	Yes	1	9	9
167	R:R:A108	R:R:F104	2.77	No	No	0	7	8
168	R:R:C109	R:R:C188	7.28	No	No	1	9	9
169	R:R:L112	R:R:P113	3.28	No	No	0	5	5
170	R:R:I116	R:R:L112	2.85	Yes	No	0	6	5
171	R:R:P113	R:R:R175	12.97	No	Yes	0	5	4
172	R:R:S114	R:R:S171	6.52	No	No	0	6	5
173	R:R:F172	R:R:S114	14.53	No	No	0	5	6
174	R:R:I116	R:R:Y291	3.63	Yes	Yes	1	6	7
175	R:R:L117	R:R:Y121	5.86	Yes	Yes	1	4	7
176	R:R:L117	R:R:T168	2.95	Yes	No	0	4	7
177	R:R:L117	R:R:S171	3	Yes	No	0	4	5
178	R:R:L117	R:R:R207	3.64	Yes	Yes	1	4	5
179	R:R:L118	R:R:L165	5.54	No	No	0	6	4
180	R:R:L118	R:R:T168	5.9	No	No	0	6	7
181	R:R:M120	R:R:W256	4.65	No	Yes	0	8	8
182	R:R:M120	R:R:Y291	5.99	No	Yes	0	8	7
183	R:R:L167	R:R:Y121	4.69	No	Yes	0	5	7
184	R:R:R207	R:R:Y121	12.35	Yes	Yes	1	5	7
185	R:R:Y121	R:R:Y259	3.97	Yes	Yes	1	7	7
186	R:R:A122	R:R:W161	7.78	No	Yes	0	7	9
187	R:R:I124	R:R:P215	3.39	No	Yes	0	8	8
188	R:R:F252	R:R:I124	7.54	Yes	No	1	9	8
189	R:R:I124	R:R:W256	14.09	No	Yes	1	8	8
190	R:R:L125	R:R:L163	5.54	No	No	0	6	4
191	R:R:L126	R:R:T129	2.95	Yes	No	0	8	7
192	R:R:C157	R:R:L126	3.17	No	Yes	5	8	8
193	R:R:A160	R:R:L126	3.15	No	Yes	0	7	8
194	R:R:L126	R:R:W161	5.69	Yes	Yes	5	8	9
195	R:R:L127	R:R:L219	4.15	No	Yes	1	8	8
196	R:R:F252	R:R:L127	3.65	Yes	No	1	9	8
197	R:R:L127	R:R:N297	4.12	No	No	0	8	9
198	R:R:I130	R:R:R134	7.52	Yes	No	0	9	9
199	R:R:L219	R:R:S131	4.5	Yes	No	1	8	9
200	R:R:C222	R:R:S131	5.16	No	No	0	8	9
201	R:R:S131	R:R:Y223	15.26	No	Yes	1	9	9
202	R:R:D133	R:R:L137	2.71	No	No	0	8	8
203	R:R:R134	R:R:Y223	10.29	No	Yes	0	9	9
204	R:R:F135	R:R:F139	18.22	No	No	10	8	8
205	R:R:C222	R:R:F135	6.98	No	No	0	8	8
206	R:R:F135	R:R:F225	5.36	No	Yes	10	8	4
207	R:R:K140	R:R:L136	2.82	No	No	6	6	6
208	R:R:L136	R:R:W143	7.97	No	No	6	6	5
209	R:R:C144	R:R:L136	3.17	No	No	6	6	6
210	R:R:C144	R:R:L137	3.17	No	No	6	6	8
211	R:R:L137	R:R:R148	9.72	No	Yes	6	8	7
212	R:R:L226	R:R:V138	5.96	No	No	7	8	8
213	R:R:T230	R:R:V138	3.17	Yes	No	7	8	8
214	R:R:F139	R:R:F225	7.5	No	Yes	10	8	4
215	R:R:F139	R:R:R229	7.48	No	No	0	8	5
216	R:R:K140	R:R:W143	6.96	No	No	6	6	5
217	R:R:V147	R:R:W143	8.58	No	No	0	4	5
218	R:R:C144	R:R:R148	2.79	No	Yes	6	6	7
219	R:R:T150	R:R:W154	4.85	Yes	Yes	5	1	4
220	R:R:L163	R:R:V210	2.98	No	No	0	4	4
221	R:R:L167	R:R:L206	4.15	No	No	0	5	3
222	R:R:L167	R:R:V210	10.43	No	No	0	5	4
223	R:R:I169	R:R:P170	3.39	No	No	0	4	7
224	R:R:P170	R:R:V203	7.07	No	No	1	7	5
225	R:R:P170	R:R:R207	5.76	No	Yes	1	7	5
226	R:R:V173	R:R:Y174	13.88	No	No	0	4	4
227	R:R:Y174	R:R:Y192	5.96	No	Yes	1	4	6
228	R:R:K199	R:R:Y174	7.17	No	No	1	1	4
229	R:R:C188	R:R:R175	4.18	No	Yes	1	9	4
230	R:R:I190	R:R:R175	10.02	No	Yes	1	4	4
231	R:R:E176	R:R:N191	6.57	No	No	0	3	5
232	R:R:K179	R:R:T186	13.51	No	No	0	3	5
233	R:R:E184	R:R:Y182	10.1	No	Yes	4	5	3
234	R:R:H185	R:R:Y182	27.22	No	Yes	4	1	3
235	R:R:E184	R:R:H185	8.62	No	No	4	5	1
236	R:R:I190	R:R:Y192	12.09	No	Yes	1	4	6
237	R:R:K199	R:R:Y192	4.78	No	Yes	1	1	6
238	R:R:E200	R:R:Y192	5.61	No	Yes	0	5	6
239	R:R:V203	R:R:Y192	5.05	No	Yes	1	5	6
240	R:R:F197	R:R:K199	3.72	No	No	0	3	1
241	R:R:K201	R:R:P198	10.04	No	No	0	4	1
242	R:R:A267	R:R:E200	3.02	No	No	0	5	5
243	R:R:K201	R:R:W268	18.57	No	No	0	4	4
244	R:R:R207	R:R:V203	6.54	Yes	No	1	5	5
245	R:R:I205	R:R:W268	5.87	No	No	0	4	4
246	R:R:L208	R:R:V264	4.47	No	No	0	5	6
247	R:R:M209	R:R:V213	4.56	No	No	0	6	5
248	R:R:G211	R:R:P215	4.06	No	Yes	0	6	8
249	R:R:F212	R:R:F252	4.29	Yes	Yes	1	8	9
250	R:R:F212	R:R:F253	6.43	Yes	No	1	8	6
251	R:R:F212	R:R:W256	3.01	Yes	Yes	1	8	8
252	R:R:F212	R:R:L257	7.31	Yes	No	1	8	6
253	R:R:F212	R:R:Q260	14.05	Yes	No	0	8	8
254	R:R:L214	R:R:V213	2.98	No	No	0	6	5
255	R:R:L216	R:R:N220	5.49	No	No	0	6	4
256	R:R:F252	R:R:L216	3.65	Yes	No	0	9	6
257	R:R:F253	R:R:L216	4.87	No	No	0	6	6
258	R:R:L219	R:R:Y223	4.69	Yes	Yes	1	8	9
259	R:R:F252	R:R:L219	7.31	Yes	Yes	1	9	8
260	R:R:N220	R:R:V249	4.43	No	No	0	4	8
261	R:R:V245	R:R:Y223	8.83	Yes	Yes	0	7	9
262	R:R:L226	R:R:T230	2.95	No	Yes	7	8	8
263	R:R:L227	R:R:W231	3.42	No	Yes	7	4	4
264	R:R:L227	R:R:L242	2.77	No	Yes	7	4	6
265	R:R:L227	R:R:V245	7.45	No	Yes	0	4	7
266	R:R:T230	R:R:W231	3.64	Yes	Yes	7	8	4
267	R:R:T230	R:R:T236	6.28	Yes	No	0	8	3
268	R:R:R237	R:R:W231	7	No	Yes	0	5	4
269	R:R:L242	R:R:W231	5.69	Yes	Yes	7	6	4
270	R:R:K234	R:R:R237	7.43	No	No	0	4	5
271	R:R:K243	R:R:T239	6.01	No	No	0	5	5
272	R:R:K240	R:R:V244	3.04	No	No	0	7	8
273	R:R:L242	R:R:M246	2.83	Yes	No	0	6	5
274	R:R:I300	R:R:V248	3.07	No	No	0	8	8
275	R:R:I250	R:R:I254	2.94	No	No	0	5	6
276	R:R:C251	R:R:F255	4.19	No	Yes	0	7	9
277	R:R:C251	R:R:V296	3.42	No	No	0	7	7
278	R:R:F252	R:R:W256	8.02	Yes	Yes	1	9	8
279	R:R:F253	R:R:L257	3.65	No	No	1	6	6
280	R:R:F255	R:R:I254	3.77	Yes	No	0	9	6
281	R:R:F255	R:R:I292	11.3	Yes	No	0	9	6
282	R:R:F255	R:R:N293	3.62	Yes	No	0	9	9
283	R:R:W256	R:R:Y259	6.75	Yes	Yes	1	8	7
284	R:R:A290	R:R:W256	3.89	No	Yes	1	8	8
285	R:R:N293	R:R:W256	7.91	No	Yes	0	9	8
286	R:R:L257	R:R:P258	3.28	No	No	0	6	9
287	R:R:C286	R:R:P258	3.77	No	No	0	7	9
288	R:R:L289	R:R:P258	4.93	No	No	0	7	9
289	R:R:Q260	R:R:Y259	7.89	No	Yes	0	8	7
290	R:R:A290	R:R:Y259	4	No	Yes	1	8	7
291	R:R:M265	R:R:V261	3.04	No	No	0	5	6
292	R:R:T262	R:R:V279	3.17	No	Yes	0	5	4
293	R:R:C286	R:R:T262	6.76	No	No	0	7	5
294	R:R:G263	R:R:I266	3.53	No	Yes	0	6	4
295	R:R:M265	R:R:V279	3.04	No	Yes	0	5	4
296	R:R:I266	R:R:L276	2.85	Yes	Yes	11	4	1
297	R:R:I266	R:R:V279	3.07	Yes	Yes	11	4	4
298	R:R:I266	R:R:N283	2.83	Yes	No	0	4	4
299	R:R:L269	R:R:P270	4.93	No	No	0	1	3
300	R:R:L269	R:R:L276	11.07	No	Yes	0	1	1
301	R:R:L276	R:R:V279	2.98	Yes	Yes	11	1	4
302	R:R:E280	R:R:L276	3.98	No	Yes	0	3	1
303	R:R:K277	R:R:K281	7.18	No	No	0	2	3
304	R:R:E280	R:R:N283	3.94	No	No	0	3	4
305	R:R:L285	R:R:S288	3	No	Yes	0	6	5
306	R:R:L285	R:R:L289	2.77	No	No	0	6	7
307	R:R:N293	R:R:N297	6.81	No	No	0	9	9
308	R:R:F308	R:R:Y301	4.13	Yes	Yes	0	8	9
309	R:R:F308	R:R:V302	13.11	Yes	No	0	8	7
310	R:R:G307	R:R:H309	3.18	No	No	0	6	7
311	R:R:G310	R:R:H309	6.35	No	No	0	5	7
312	L:L:A691	L:L:Y694	2.67	No	Yes	0	5	5
313	L:L:A691	L:L:Y704	2.67	No	Yes	0	5	3
314	R:R:L208	R:R:Q260	2.66	No	No	0	5	8
315	L:L:R755	R:R:V287	2.62	Yes	No	0	9	5
316	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
317	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
318	R:R:R233	R:R:T236	2.59	No	No	0	4	3
319	R:R:V248	R:R:Y223	2.52	No	Yes	0	8	9
320	R:R:F75	R:R:I130	2.51	No	Yes	0	8	9
321	R:R:F225	R:R:I221	2.51	Yes	No	0	4	5
322	R:R:V264	R:R:W268	2.45	No	No	0	6	4
323	R:R:F308	R:R:L57	2.44	Yes	No	8	8	6
324	R:R:F308	R:R:L312	2.44	Yes	No	8	8	6
325	R:R:T95	R:R:W102	2.43	No	Yes	0	5	9
326	L:L:E688	L:L:Y704	2.24	No	Yes	0	1	3
327	R:R:G193	R:R:G194	2.11	No	No	0	4	1
328	R:R:G194	R:R:G195	2.11	No	No	0	1	1
329	L:L:Y704	R:R:F181	2.06	Yes	Yes	0	3	1
330	R:R:G36	R:R:P35	2.03	No	Yes	0	4	4
331	R:R:G54	R:R:P53	2.03	No	No	0	8	4
332	R:R:C86	R:R:G51	1.96	No	No	0	7	8
333	R:R:C295	R:R:G51	1.96	No	No	0	8	8
334	R:R:A39	R:R:G36	1.95	No	No	0	5	4
335	R:R:P270	R:R:P271	1.95	No	No	0	3	1
336	R:R:A128	R:R:P215	1.87	No	Yes	0	7	8
337	L:L:V751	R:R:G189	1.84	No	No	0	3	2
338	R:R:G149	R:R:V70	1.84	No	No	0	6	6
339	L:L:T723	R:R:G27	1.82	No	No	0	2	5
340	R:R:G151	R:R:T150	1.82	No	Yes	0	4	1
341	R:R:A177	R:R:C109	1.81	No	No	0	4	9
342	R:R:A132	R:R:C222	1.81	No	No	0	6	8
343	L:L:A707	L:L:A739	1.79	No	No	0	6	6
344	R:R:A122	R:R:A164	1.79	No	No	0	7	7
345	R:R:A204	R:R:A267	1.79	No	No	0	5	5
346	L:L:P747	L:L:S746	1.78	No	No	0	3	3
347	R:R:P274	R:R:S273	1.78	No	No	0	1	2
348	L:L:G754	R:R:I116	1.76	No	Yes	0	6	6
349	R:R:P215	R:R:T218	1.75	Yes	No	0	8	7
350	R:R:P274	R:R:T275	1.75	No	No	0	1	1
351	L:L:C702	L:L:V698	1.71	No	Yes	2	9	1
352	L:L:C728	L:L:V698	1.71	No	Yes	2	8	1
353	R:R:G310	R:R:L313	1.71	No	No	0	5	4
354	R:R:A79	R:R:V59	1.7	No	No	0	9	7
355	R:R:G193	R:R:N191	1.7	No	No	0	4	5
356	R:R:A304	R:R:V244	1.7	No	No	0	7	8
357	L:L:C715	L:L:T737	1.69	No	Yes	3	9	3
358	L:L:C736	L:L:T737	1.69	Yes	Yes	3	9	3
359	R:R:A72	R:R:T62	1.68	No	No	0	7	7
360	R:R:K140	R:R:P141	1.67	No	No	0	6	8
361	R:R:L30	R:R:P31	1.64	No	No	0	1	3
362	R:R:L214	R:R:P215	1.64	No	Yes	0	6	8
363	R:R:A39	R:R:I42	1.62	No	No	0	5	5
364	R:R:S45	R:R:V46	1.62	No	No	0	5	6
365	R:R:A247	R:R:I300	1.62	No	No	0	6	8
366	R:R:V46	R:R:V50	1.6	No	No	0	6	6
367	R:R:S238	R:R:T241	1.6	No	No	0	6	7
368	R:R:V244	R:R:V245	1.6	No	Yes	0	8	7
369	R:R:T241	R:R:V245	1.59	No	Yes	0	7	7
370	R:R:A56	R:R:L83	1.58	No	No	0	4	8
371	L:L:C715	L:L:N740	1.57	No	No	3	9	3
372	L:L:C736	L:L:N740	1.57	Yes	No	3	9	3
373	R:R:T94	R:R:T95	1.57	No	No	0	5	5
374	R:R:A106	R:R:D105	1.54	No	No	0	2	7
375	R:R:I110	R:R:V111	1.54	No	No	0	7	5
376	R:R:A66	R:R:E65	1.51	No	No	0	6	5
377	L:L:K741	L:L:T737	1.5	No	Yes	0	2	3
378	R:R:L276	R:R:S273	1.5	Yes	No	0	1	2
379	R:R:L115	R:R:V111	1.49	No	No	0	6	5
380	R:R:L217	R:R:V213	1.49	No	No	0	3	5
381	L:L:I738	L:L:I742	1.47	No	No	2	3	3
382	R:R:L228	R:R:T224	1.47	No	No	0	1	3
383	R:R:L242	R:R:T239	1.47	Yes	No	0	6	5
384	R:R:E184	R:R:S183	1.44	No	No	0	5	3
385	R:R:I169	R:R:L166	1.43	No	No	0	4	4
386	R:R:L152	R:R:M155	1.41	No	No	0	4	3
387	R:R:G158	R:R:W161	1.41	No	Yes	0	4	9
388	L:L:P699	L:L:Y694	1.39	Yes	Yes	2	1	5
389	L:L:H696	L:L:S697	1.39	Yes	No	0	4	1
390	L:L:A707	R:R:F181	1.39	No	Yes	0	6	1
391	L:L:D705	L:L:K701	1.38	No	No	0	3	1
392	L:L:A720	L:L:R721	1.38	No	No	0	2	8
393	R:R:L115	R:R:L118	1.38	No	No	0	6	6
394	R:R:A235	R:R:R233	1.38	No	No	0	4	4
395	L:L:E734	L:L:N733	1.31	Yes	No	0	3	1
396	R:R:R311	R:R:V61	1.31	No	No	0	5	7
397	R:R:R278	R:R:V279	1.31	No	Yes	0	1	4
398	R:R:F225	R:R:T224	1.3	Yes	No	0	4	3
399	L:L:E688	L:L:Q685	1.27	No	No	0	1	2
400	L:L:L682	L:L:R684	1.21	No	No	0	2	1
401	L:L:K693	L:L:Y694	1.19	No	Yes	0	4	5
402	R:R:D180	R:R:F181	1.19	No	Yes	0	1	1
403	R:R:R67	R:R:R68	1.07	Yes	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y694	4.27333	6	2	5
2	L:L:H696	5.5675	4	2	4
3	L:L:V698	3.392	5	2	1
4	L:L:P699	4.244	5	2	1
5	L:L:Y704	2.9375	4	0	3
6	L:L:R708	12.2475	4	3	1
7	L:L:F711	9.01667	6	4	3
8	L:L:E713	8.194	5	3	5
9	L:L:R718	8.13167	6	3	8
10	L:L:L727	5.51	4	2	1
11	L:L:F732	6.212	5	3	8
12	L:L:E734	6.946	5	2	3
13	L:L:C736	4.38	4	3	9
14	L:L:T737	1.95	4	3	3
15	L:L:L753	4.88	4	1	8
16	L:L:R755	6.095	6	0	9
17	R:R:D26	8.225	4	0	3
18	R:R:P35	3.365	4	0	4
19	R:R:Y44	4.228	5	1	8
20	R:R:R67	4.756	5	5	5
21	R:R:I73	9.3225	4	5	6
22	R:R:W74	7.254	5	0	7
23	R:R:N77	7.3475	4	5	9
24	R:R:D82	9.0325	4	9	9
25	R:R:L92	3.75	4	1	6
26	R:R:V96	3.2175	4	1	5
27	R:R:W102	6.842	5	1	9
28	R:R:I116	2.865	6	1	6
29	R:R:L117	3.8625	4	1	4
30	R:R:Y121	6.7175	4	1	7
31	R:R:L126	4.09	5	5	8
32	R:R:I130	4.6875	4	0	9
33	R:R:R148	9.46	4	6	7
34	R:R:T150	4.1	4	5	1
35	R:R:W154	9.3675	4	5	4
36	R:R:W161	4.624	5	5	9
37	R:R:R175	7.382	5	1	4
38	R:R:F181	3.6725	4	0	1
39	R:R:Y182	19.19	4	4	3
40	R:R:Y192	6.698	5	1	6
41	R:R:R207	7.0725	4	1	5
42	R:R:F212	7.018	5	1	8
43	R:R:P215	2.542	5	0	8
44	R:R:L219	5.1625	4	1	8
45	R:R:Y223	8.318	5	1	9
46	R:R:F225	4.1675	4	10	4
47	R:R:T230	4.01	4	7	8
48	R:R:W231	4.9375	4	7	4
49	R:R:L242	3.19	4	7	6
50	R:R:V245	4.8675	4	0	7
51	R:R:F252	5.74333	6	1	9
52	R:R:F255	5.72	4	0	9
53	R:R:W256	6.90286	7	1	8
54	R:R:Y259	6.992	5	1	7
55	R:R:I266	3.07	4	11	4
56	R:R:L276	4.476	5	11	1
57	R:R:V279	2.714	5	11	4
58	R:R:S288	5.6575	4	0	5
59	R:R:Y291	4.52833	6	1	7
60	R:R:Y301	9.0125	4	0	9
61	R:R:F308	5.472	5	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E745	L:L:L683	75.199	3.98	No	No	0	1	4
2	L:L:I738	L:L:I742	71.7535	1.47	No	No	2	3	3
3	L:L:E734	L:L:I738	69.8188	8.2	Yes	No	2	3	3
4	L:L:E734	L:L:Y694	30.2546	5.61	Yes	Yes	2	3	5
5	L:L:A691	L:L:Y694	15.5947	2.67	No	Yes	0	5	5
6	L:L:A691	L:L:Y704	14.4235	2.67	No	Yes	0	5	3
7	L:L:P699	L:L:Y694	12.1165	1.39	Yes	Yes	2	1	5
8	L:L:E734	L:L:N733	42.0994	1.31	Yes	No	0	3	1
9	L:L:N733	L:L:T737	41.056	2.92	No	Yes	0	1	3
10	L:L:C736	L:L:T737	36.6539	1.69	Yes	Yes	3	9	3
11	L:L:C736	L:L:F732	34.5996	6.98	Yes	Yes	3	9	8
12	L:L:F732	L:L:R718	22.1461	6.41	Yes	Yes	3	8	8
13	L:L:R718	R:R:D26	13.1083	3.57	Yes	Yes	0	8	3
14	L:L:F711	L:L:K749	78.9652	7.44	Yes	No	4	3	4
15	L:L:K749	L:L:P747	78.5576	8.36	No	No	0	4	3
16	L:L:P747	L:L:S746	77.7262	1.78	No	No	0	3	3
17	L:L:E745	L:L:S746	76.8892	10.06	No	No	0	1	3
18	L:L:F711	R:R:Y182	10.8421	15.47	Yes	Yes	4	3	3
19	L:L:F711	L:L:Y712	90.0981	9.28	Yes	No	0	3	2
20	L:L:Y712	R:R:K32	90.8399	9.55	No	No	0	2	4
21	L:L:V751	R:R:G189	10.3829	1.84	No	No	0	3	2
22	L:L:V751	R:R:R175	11.3231	6.54	No	Yes	1	3	4
23	L:L:R755	R:R:R175	21.3309	3.2	Yes	Yes	0	9	4
24	L:L:R755	R:R:T262	21.4206	5.17	Yes	No	0	9	5
25	R:R:C286	R:R:T262	18.6354	6.76	No	No	0	7	5
26	R:R:C286	R:R:P258	19.1163	3.77	No	No	0	7	9
27	R:R:L289	R:R:P258	67.7536	4.93	No	No	0	7	9
28	R:R:L285	R:R:L289	67.5579	2.77	No	No	0	6	7
29	R:R:D37	R:R:L285	100	5.43	No	No	0	4	6
30	R:R:D37	R:R:K281	98.6522	4.15	No	No	0	4	3
31	R:R:K281	R:R:P35	97.2827	5.02	No	Yes	0	3	4
32	R:R:P35	R:R:V38	93.7638	3.53	Yes	No	0	4	6
33	R:R:Q34	R:R:V38	93.0437	5.73	No	No	0	4	6
34	R:R:H99	R:R:Q34	92.3181	7.42	No	No	0	4	4
35	R:R:H99	R:R:K32	91.5763	15.72	No	No	0	4	4
36	R:R:P113	R:R:R175	13.7741	12.97	No	Yes	0	5	4
37	L:L:L753	R:R:P113	11.6328	8.21	Yes	No	0	8	5
38	L:L:L753	R:R:L92	15.6327	2.77	Yes	Yes	1	8	6
39	R:R:L92	R:R:Y44	13.7605	4.69	Yes	Yes	1	6	8
40	R:R:S288	R:R:Y44	33.4692	3.82	Yes	Yes	0	5	8
41	R:R:L285	R:R:S288	34.8659	3	No	Yes	0	6	5
42	R:R:I190	R:R:R175	13.3366	10.02	No	Yes	1	4	4
43	R:R:Y291	R:R:Y44	17.6055	2.98	Yes	Yes	1	7	8
44	R:R:M120	R:R:Y291	30.0019	5.99	No	Yes	0	8	7
45	R:R:M120	R:R:W256	30.1541	4.65	No	Yes	0	8	8
46	R:R:W256	R:R:Y259	51.0611	6.75	Yes	Yes	1	8	7
47	R:R:L257	R:R:P258	50.2948	3.28	No	No	0	6	9
48	R:R:F212	R:R:L257	49.3275	7.31	Yes	No	1	8	6
49	R:R:F212	R:R:W256	11.9453	3.01	Yes	Yes	1	8	8
50	R:R:F212	R:R:Q260	12.3855	14.05	Yes	No	0	8	8
51	R:R:Q260	R:R:Y259	10.0079	7.89	No	Yes	0	8	7
52	L:L:R755	R:R:Y259	36.999	12.35	Yes	Yes	0	9	7
53	L:L:R755	R:R:N283	11.2986	7.23	Yes	No	0	9	4
54	R:R:L89	R:R:V47	19.2033	2.98	No	No	0	8	8
55	R:R:C295	R:R:V47	18.1082	10.25	No	No	0	8	8
56	R:R:C295	R:R:G51	13.8366	1.96	No	No	0	8	8
57	R:R:C86	R:R:G51	12.7795	1.96	No	No	0	7	8
58	R:R:C86	R:R:D82	11.8149	4.67	No	Yes	0	7	9
59	R:R:F212	R:R:F252	32.779	4.29	Yes	Yes	1	8	9
60	R:R:F252	R:R:L219	70.0932	7.31	Yes	Yes	1	9	8
61	R:R:L219	R:R:Y223	64.0689	4.69	Yes	Yes	1	8	9
62	R:R:R134	R:R:Y223	50.6372	10.29	No	Yes	0	9	9
63	R:R:I130	R:R:R134	49.9552	7.52	Yes	No	0	9	9
64	R:R:F75	R:R:I130	21.9478	2.51	No	Yes	0	8	9
65	R:R:F75	R:R:Y301	21.0864	20.63	No	Yes	0	8	9
66	R:R:F308	R:R:Y301	13.8801	4.13	Yes	Yes	0	8	9
67	R:R:I130	R:R:W74	31.4312	5.87	Yes	Yes	0	9	7
68	R:R:D133	R:R:W74	12.4453	18.98	No	Yes	0	8	7
69	R:R:D133	R:R:L137	11.4426	2.71	No	No	0	8	8
70	R:R:T129	R:R:W74	10.2497	3.64	No	Yes	0	7	7
71	R:R:Y121	R:R:Y259	40.469	3.97	Yes	Yes	1	7	7
72	R:R:L117	R:R:Y121	18.2033	5.86	Yes	Yes	1	4	7
73	R:R:L117	R:R:T168	11.3448	2.95	Yes	No	0	4	7
74	R:R:R207	R:R:Y121	11.8122	12.35	Yes	Yes	1	5	7
75	R:R:I124	R:R:P215	13.2795	3.39	No	Yes	0	8	8
76	R:R:V245	R:R:Y223	20.2848	8.83	Yes	Yes	0	7	9
77	R:R:L227	R:R:V245	14.4507	7.45	No	Yes	0	4	7
78	R:R:I190	R:R:Y192	12.5268	12.09	No	Yes	1	4	6
79	R:R:T262	R:R:V279	11.2877	3.17	No	Yes	0	5	4
80	L:L:I742	L:L:L683	72.248	11.42	No	No	2	3	4
81	R:R:L89	R:R:Y291	11.6274	3.52	No	Yes	1	8	7
82	R:R:F252	R:R:W256	39.4473	8.02	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R684	R:R:Y178	7.2	0	No	No	1	1	0	1
L:L:R684	R:R:D180	13.1	0	No	No	1	1	0	1
L:L:I687	R:R:F181	10.05	0	No	Yes	7	1	0	1
L:L:K701	R:R:P24	3.35	0	No	No	1	3	0	1
L:L:D705	R:R:D26	6.65	0	No	Yes	3	3	0	1
L:L:V709	R:R:Y182	23.97	4	No	Yes	4	3	0	1
L:L:F711	R:R:Y182	15.47	4	Yes	Yes	3	3	0	1
L:L:F711	R:R:V187	3.93	4	Yes	No	3	1	0	1
L:L:Y712	R:R:K32	9.55	0	No	No	2	4	0	1
L:L:E713	R:R:L30	5.3	3	Yes	No	5	1	0	1
L:L:R718	R:R:D26	3.57	3	Yes	Yes	8	3	0	1
L:L:R718	R:R:L30	7.29	3	Yes	No	8	1	0	1
L:L:R721	R:R:I28	8.77	0	No	No	8	4	0	1
L:L:H748	R:R:E176	4.92	0	No	No	5	3	0	1
L:L:H748	R:R:G189	3.18	0	No	No	5	2	0	1
L:L:P750	R:R:V187	10.6	4	No	No	1	1	0	1
L:L:V751	R:R:R175	6.54	1	No	Yes	3	4	0	1
L:L:V751	R:R:I190	4.61	1	No	No	3	4	0	1
L:L:Q752	R:R:V96	2.87	1	No	Yes	4	5	0	1
L:L:Q752	R:R:N100	11.88	1	No	No	4	3	0	1
L:L:Q752	R:R:S284	8.66	1	No	No	4	4	0	1
L:L:L753	R:R:L92	2.77	1	Yes	Yes	8	6	0	1
L:L:L753	R:R:W102	5.69	1	Yes	Yes	8	9	0	1
L:L:L753	R:R:P113	8.21	1	Yes	No	8	5	0	1
L:L:L753	R:R:I116	2.85	1	Yes	Yes	8	6	0	1
L:L:R755	R:R:R175	3.2	0	Yes	Yes	9	4	0	1
L:L:R755	R:R:Y259	12.35	0	Yes	Yes	9	7	0	1
L:L:R755	R:R:T262	5.17	0	Yes	No	9	5	0	1
L:L:R755	R:R:G263	6	0	Yes	No	9	6	0	1
L:L:R755	R:R:N283	7.23	0	Yes	No	9	4	0	1
R:R:D26	R:R:G27	5.03	0	Yes	No	3	5	1	1
R:R:D26	R:R:H29	17.65	0	Yes	No	3	3	1	2
R:R:H99	R:R:K32	15.72	0	No	No	4	4	2	1
R:R:L41	R:R:V96	2.98	0	No	Yes	4	5	2	1
R:R:L92	R:R:Y44	4.69	1	Yes	Yes	6	8	1	2
R:R:V96	R:R:Y44	3.79	1	Yes	Yes	5	8	1	2
R:R:Y291	R:R:Y44	2.98	1	Yes	Yes	7	8	2	2
R:R:A88	R:R:I116	3.25	0	No	Yes	7	6	2	1
R:R:I116	R:R:L92	2.85	1	Yes	Yes	6	6	1	1
R:R:L92	R:R:Y291	4.69	1	Yes	Yes	6	7	1	2
R:R:S284	R:R:V96	3.23	1	No	Yes	4	5	1	1
R:R:F104	R:R:W102	13.03	0	No	Yes	8	9	2	1
R:R:C109	R:R:W102	5.22	1	No	Yes	9	9	2	1
R:R:C188	R:R:W102	7.84	1	No	Yes	9	9	2	1
R:R:C109	R:R:C188	7.28	1	No	No	9	9	2	2
R:R:L112	R:R:P113	3.28	0	No	No	5	5	2	1
R:R:I116	R:R:L112	2.85	1	Yes	No	6	5	1	2
R:R:P113	R:R:R175	12.97	0	No	Yes	5	4	1	1
R:R:I116	R:R:Y291	3.63	1	Yes	Yes	6	7	1	2
R:R:Y121	R:R:Y259	3.97	1	Yes	Yes	7	7	2	1
R:R:C188	R:R:R175	4.18	1	No	Yes	9	4	2	1
R:R:I190	R:R:R175	10.02	1	No	Yes	4	4	1	1
R:R:E176	R:R:N191	6.57	0	No	No	3	5	1	2
R:R:E184	R:R:Y182	10.1	4	No	Yes	5	3	2	1
R:R:H185	R:R:Y182	27.22	4	No	Yes	1	3	2	1
R:R:E184	R:R:H185	8.62	4	No	No	5	1	2	2
R:R:I190	R:R:Y192	12.09	1	No	Yes	4	6	1	2
R:R:W256	R:R:Y259	6.75	1	Yes	Yes	8	7	2	1
R:R:A290	R:R:W256	3.89	1	No	Yes	8	8	2	2
R:R:Q260	R:R:Y259	7.89	0	No	Yes	8	7	2	1
R:R:A290	R:R:Y259	4	1	No	Yes	8	7	2	1
R:R:T262	R:R:V279	3.17	0	No	Yes	5	4	1	2
R:R:C286	R:R:T262	6.76	0	No	No	7	5	2	1
R:R:G263	R:R:I266	3.53	0	No	Yes	6	4	1	2
R:R:I266	R:R:V279	3.07	11	Yes	Yes	4	4	2	2
R:R:I266	R:R:N283	2.83	11	Yes	No	4	4	2	1
R:R:E280	R:R:N283	3.94	0	No	No	3	4	2	1
L:L:R755	R:R:V287	2.62	0	Yes	No	9	5	0	1
R:R:T95	R:R:W102	2.43	0	No	Yes	5	9	2	1
L:L:Y704	R:R:F181	2.06	0	Yes	Yes	3	1	0	1
L:L:V751	R:R:G189	1.84	1	No	No	3	2	0	1
L:L:T723	R:R:G27	1.82	0	No	No	2	5	0	1
L:L:G754	R:R:I116	1.76	0	No	Yes	6	6	0	1
R:R:L30	R:R:P31	1.64	3	No	No	1	3	1	2
L:L:A707	R:R:F181	1.39	0	No	Yes	6	1	0	1
R:R:D180	R:R:F181	1.19	0	No	Yes	1	1	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KWG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.71
Number of Linked Nodes	344
Number of Links	403
Number of Hubs	61
Number of Links mediated by Hubs	223
Number of Communities	11
Number of Nodes involved in Communities	100
Number of Links involved in Communities	137

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	81992
Length Of Smallest Path	3
Average Path Length	18.7226
Length of Longest Path	44
Minimum Path Strength	1.29
Average Path Strength	6.08849
Maximum Path Strength	25.595
Minimum Path Correlation	0.7
Average Path Correlation	0.953542
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	58.7182
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.4602
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Anaphylotoxins (complement system)
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Anaphylotoxins (complement system)
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	C5a
UniProt	P06684
Sequence	>9KWG_nogp_Chain_L L L R Q K I E E Q A A K Y K H S V P K K C C Y D G A R V N F Y E T C E E R V A R V T G P L C I R A F N E C C T I A N K I R K E S P H K P V Q L G R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30993
Sequence	>9KWG_nogp_Chain_R P A D G I H L P K R Q P G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A R R A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H N Y W Y F D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q K V R G T G L A W M A C G V A W V L A L L L T I P S F V Y R E A Y K D F Y S E H T V C G I N Y G G G S F P K E K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R K A T R S T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L P P S S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F H G R L L R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KWG	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWX	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.13	2025-11-26	10.1101/2025.05.26.656101
	9KWX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.13	2025-11-26	10.1101/2025.05.26.656101
	9KX6	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.11	2025-11-26	10.1101/2025.05.26.656101
	9KX6 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.11	2025-11-26	10.1101/2025.05.26.656101
	9KXS	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-	Go/β1/γ2	3.31	2025-11-26	10.1101/2025.05.26.656101
	9KXS (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-		3.31	2025-11-26	10.1101/2025.05.26.656101
	9UMR	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMR (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMX	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-	Go/β1/γ2	3.2	2025-11-26	10.1101/2025.05.26.656101
	9UMX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-		3.2	2025-11-26	10.1101/2025.05.26.656101
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.54	2025-01-15	To be published
	9KUG	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-	Go/β1/γ2	3.07	2025-11-26	10.1101/2025.05.26.656101
	9KUG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-		3.07	2025-11-26	10.1101/2025.05.26.656101

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KWG_nogp.zip

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