Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:I683 4.27333626
2L:L:Y690 6.0375405
3L:L:N706 6.5525486
4L:L:R714 12.1675487
5L:L:F728 5.8025409
6L:L:V734 2.655403
7L:L:H744 8.41523
8L:L:Q748 3.5925415
9L:L:L749 4.43429718
10R:R:K28 8.75483
11R:R:F44 6.632517
12R:R:V47 3.85406
13R:R:E65 14.6445
14R:R:I73 6.6525436
15R:R:W74 6.89667607
16R:R:N77 6.306539
17R:R:L78 4.75167639
18R:R:D82 5.9925409
19R:R:L89 4.2775407
20R:R:H101 6.5625404
21R:R:W102 8.97478
22R:R:C109 4.674579
23R:R:M120 5.9225417
24R:R:F139 7.9425467
25R:R:W161 4.114509
26R:R:R175 4.982505
27R:R:R178 7.62422
28R:R:E180 9.8525421
29R:R:F182 7.91333623
30R:R:P183 6.0275424
31R:R:Y192 7.896555
32R:R:R198 6.2175453
33R:R:V202 3.8975455
34R:R:F211 6.7525408
35R:R:P214 3.3425409
36R:R:Y222 9.942508
37R:R:W230 8.92254114
38R:R:F251 5.234519
39R:R:F254 8.938518
40R:R:W255 7.66667619
41R:R:Y258 4.1925417
42R:R:Q259 8.295418
43R:R:T261 4.206514
44R:R:M265 5.968514
45R:R:F267 6.964104
46R:R:L268 6.3325402
47R:R:E269 5.0125403
48R:R:K280 3.885492
49R:R:D282 5.5675414
50R:R:V286 3.824515
51R:R:F288 6.055418
52R:R:Y290 6.13714717
53R:R:I291 7.5175415
54R:R:C294 4.1975407
55R:R:N296 8.2675439
56R:R:Y300 6.51739
57R:R:F307 7.75649
58R:R:R310 12.2867644
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:K185 R:R:P183 29.65916.69NoYes034
2R:R:H101 R:R:K185 27.500310.48YesNo043
3L:L:I683 R:R:F182 49.89611.3YesYes263
4L:L:I683 L:L:V734 46.15241.54YesYes063
5L:L:C698 L:L:F728 14.11351.4NoYes099
6L:L:F728 L:L:R714 22.016616.03YesYes097
7L:L:C711 L:L:R714 32.8345.57NoYes097
8L:L:C711 L:L:C732 33.88977.28NoNo099
9L:L:C732 L:L:R739 34.94012.79NoNo096
10L:L:R739 L:L:S736 35.99056.59NoNo063
11L:L:S736 L:L:V733 37.03043.23NoNo033
12L:L:V733 L:L:V734 38.0651.6NoYes033
13L:L:C698 L:L:C724 12.9637.28NoNo099
14L:L:C724 L:L:L720 11.80737.94NoNo091
15R:R:E180 R:R:F182 53.550111.66YesYes213
16R:R:H101 R:R:Q98 19.77892.47YesNo044
17R:R:Q98 R:R:V97 18.65472.87NoNo043
18R:R:F93 R:R:V97 17.52532.62NoNo073
19R:R:F93 R:R:L41 15.25089.74NoNo075
20R:R:I38 R:R:L41 14.10564.28NoNo055
21R:R:I38 R:R:V42 12.95513.07NoNo055
22R:R:L39 R:R:V42 11.79941.49NoNo055
23R:R:L284 R:R:L39 10.63842.77NoNo045
24R:R:E180 R:R:R178 82.89852.33YesYes212
25R:R:L187 R:R:R178 83.49619.72NoYes242
26L:L:D746 R:R:L187 89.09836.79NoNo014
27L:L:D746 R:R:H100 89.82498.82NoNo014
28L:L:Q748 R:R:H100 93.36052.47YesNo054
29L:L:Q748 R:R:D282 28.58233.92YesYes154
30R:R:D282 R:R:M265 71.388711.09YesYes144
31R:R:L278 R:R:M265 16.75925.65NoYes044
32R:R:L278 R:R:M264 15.76152.83NoNo044
33R:R:L268 R:R:M264 14.85854.24YesNo024
34R:R:E269 R:R:L268 14.67953.98YesYes032
35R:R:E269 R:R:S272 11.88110.06YesNo034
36R:R:P273 R:R:S272 19.03653.56NoNo024
37L:L:E709 R:R:P273 15.20071.57NoNo052
38L:L:E709 L:L:T710 11.55198.47NoNo057
39R:R:K279 R:R:M265 19.84475.76NoYes044
40R:R:F275 R:R:K279 18.941712.41NoNo034
41R:R:F275 R:R:L268 15.10869.74NoYes032
42R:R:L268 R:R:T274 13.06577.37YesNo021
43R:R:S272 R:R:T274 10.99914.8NoNo041
44L:L:M747 R:R:M265 36.50394.33NoYes044
45L:L:M747 R:R:V190 35.61414.56NoNo045
46R:R:V190 R:R:Y192 18.08876.31NoYes055
47L:L:L749 L:L:Q748 64.69662.66YesYes185
48L:L:L749 R:R:M120 16.94884.24YesYes187
49R:R:D282 R:R:V286 55.50612.92YesYes145
50L:L:L749 R:R:Y290 43.80157.03YesYes187
51R:R:V47 R:R:Y290 18.18612.52YesYes067
52R:R:C294 R:R:V47 10.3126.83YesYes076
53R:R:C293 R:R:Y290 1004.03NoYes087
54R:R:C293 R:R:D82 99.76046.22NoYes089
55R:R:D82 R:R:N55 15.97476.73YesNo099
56R:R:N55 R:R:P297 15.161211.4NoNo099
57R:R:D82 R:R:N296 53.45278.08YesYes099
58R:R:N296 R:R:P297 21.35329.77YesNo099
59R:R:P297 R:R:V58 34.17661.77NoNo098
60R:R:V301 R:R:V58 27.12121.6NoNo068
61R:R:F307 R:R:V301 25.344211.8YesNo096
62R:R:F307 R:R:R310 16.35653.21YesYes494
63R:R:D82 R:R:S123 31.16762.94YesNo099
64R:R:L78 R:R:S123 30.73843YesNo099
65R:R:L126 R:R:L78 42.29044.15NoYes379
66R:R:L126 R:R:N77 39.03124.12NoYes379
67R:R:L78 R:R:N296 33.03158.24YesYes399
68R:R:I130 R:R:L78 27.51354.28NoYes089
69R:R:I130 R:R:W74 31.37293.52NoYes087
70R:R:D133 R:R:W74 17.222618.98NoYes087
71R:R:N77 R:R:W161 27.27394.52YesYes099
72R:R:N119 R:R:W161 10.59372.26NoYes099
73R:R:R175 R:R:V190 20.84773.92YesNo055
74R:R:C109 R:R:R175 10.68584.18YesYes095
75R:R:M120 R:R:W255 26.37094.65YesYes179
76R:R:V202 R:R:Y192 10.56475.05YesYes555
77R:R:I124 R:R:P214 10.86483.39NoYes089
78R:R:F251 R:R:W255 22.19569.02YesYes199
79R:R:F251 R:R:L218 28.34543.65YesNo098
80R:R:L218 R:R:S131 28.12436.01NoNo089
81R:R:C221 R:R:S131 11.13335.16NoNo069
82R:R:S131 R:R:Y222 25.412710.17NoYes098
83R:R:D133 R:R:L137 15.68788.14NoNo088
84R:R:C144 R:R:L137 14.14243.17NoNo058
85R:R:C144 R:R:K140 11.03591.62NoNo056
86R:R:Q259 R:R:W255 13.12364.38YesYes189
87R:R:L207 R:R:Q259 16.87777.99NoYes058
88R:R:I263 R:R:L207 15.28765.71NoNo055
89R:R:F267 R:R:I263 11.96525.02YesNo1045
90R:R:V286 R:R:Y258 25.60752.52YesYes157
91R:R:Q259 R:R:Y258 12.5266.76YesYes187
92R:R:V244 R:R:Y222 15.856315.14NoYes078
93R:R:L226 R:R:V244 14.563611.92NoNo057
94R:R:L226 R:R:L241 10.65424.15NoNo056
95R:R:N296 R:R:Y300 11.63096.98YesYes399
96R:R:E180 R:R:P183 27.826812.58YesYes214
97R:R:V286 R:R:Y290 41.09253.79YesYes157
98R:R:M120 R:R:Y290 11.154411.97YesYes177
99R:R:W255 R:R:Y258 11.16764.82YesYes197
100R:R:R134 R:R:Y222 15.00869.26NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L679 R:R:F182 6.09 0 No Yes 4 3 0 1
L:L:Q680 R:R:Y181 14.65 0 No No 1 1 0 1
L:L:I683 R:R:F182 11.3 2 Yes Yes 6 3 0 1
L:L:Y700 R:R:F182 7.22 0 No Yes 4 3 0 1
L:L:D701 R:R:P25 6.44 0 No No 3 8 0 1
L:L:D701 R:R:D27 11.98 0 No No 3 9 0 1
L:L:A703 R:R:F182 8.32 2 No Yes 7 3 0 1
L:L:V705 R:R:E180 12.84 0 No Yes 4 1 0 1
L:L:N706 R:R:K28 11.19 8 Yes Yes 6 3 0 1
L:L:N707 R:R:L276 15.1 0 No No 3 3 0 1
L:L:R714 R:R:K28 21.04 8 Yes Yes 7 3 0 1
L:L:R717 R:R:T29 9.06 0 No No 7 5 0 1
L:L:I742 R:R:R178 3.76 2 No Yes 3 2 0 1
L:L:S743 R:R:H194 4.18 0 No No 3 1 0 1
L:L:H744 R:R:R178 14.67 2 Yes Yes 3 2 0 1
L:L:H744 R:R:L187 2.57 2 Yes No 3 4 0 1
L:L:H744 R:R:G189 3.18 2 Yes No 3 4 0 1
L:L:H744 R:R:D191 17.65 2 Yes No 3 4 0 1
L:L:K745 R:R:E199 2.7 0 No No 4 4 0 1
L:L:K745 R:R:P270 3.35 0 No No 4 3 0 1
L:L:K745 R:R:F275 2.48 0 No No 4 3 0 1
L:L:D746 R:R:H100 8.82 0 No No 1 4 0 1
L:L:D746 R:R:L187 6.79 0 No No 1 4 0 1
L:L:M747 R:R:V190 4.56 0 No No 4 5 0 1
L:L:M747 R:R:M265 4.33 0 No Yes 4 4 0 1
L:L:Q748 R:R:L92 5.32 1 Yes No 5 6 0 1
L:L:Q748 R:R:H100 2.47 1 Yes No 5 4 0 1
L:L:Q748 R:R:D282 3.92 1 Yes Yes 5 4 0 1
L:L:L749 R:R:L92 4.15 1 Yes No 8 6 0 1
L:L:L749 R:R:I116 2.85 1 Yes No 8 6 0 1
L:L:L749 R:R:L117 4.15 1 Yes No 8 4 0 1
L:L:L749 R:R:M120 4.24 1 Yes Yes 8 7 0 1
L:L:L749 R:R:V286 5.96 1 Yes Yes 8 5 0 1
L:L:L749 R:R:Y290 7.03 1 Yes Yes 8 7 0 1
L:L:G750 R:R:L117 5.13 0 No No 6 4 0 1
R:R:N31 R:R:T29 5.85 0 No No 1 5 2 1
R:R:F44 R:R:L92 8.53 1 Yes No 7 6 2 1
R:R:F44 R:R:V286 3.93 1 Yes Yes 7 5 2 1
R:R:F44 R:R:Y290 5.16 1 Yes Yes 7 7 2 1
R:R:V47 R:R:Y290 2.52 0 Yes Yes 6 7 2 1
R:R:A88 R:R:I116 4.87 0 No No 6 6 2 1
R:R:H100 R:R:I96 2.65 0 No No 4 5 1 2
R:R:I116 R:R:Y290 8.46 1 No Yes 6 7 1 1
R:R:L117 R:R:M120 2.83 1 No Yes 4 7 1 1
R:R:M120 R:R:W255 4.65 1 Yes Yes 7 9 1 2
R:R:M120 R:R:Y290 11.97 1 Yes Yes 7 7 1 1
R:R:R175 R:R:V190 3.92 0 Yes No 5 5 2 1
R:R:D191 R:R:V176 13.15 0 No No 4 4 1 2
R:R:L187 R:R:R178 9.72 2 No Yes 4 2 1 1
R:R:E179 R:R:Y181 12.35 0 No No 2 1 2 1
R:R:E180 R:R:F182 11.66 2 Yes Yes 1 3 1 1
R:R:E180 R:R:P183 12.58 2 Yes Yes 1 4 1 2
R:R:F182 R:R:P183 2.89 2 Yes Yes 3 4 1 2
R:R:V190 R:R:Y192 6.31 0 No Yes 5 5 1 2
R:R:E199 R:R:Y192 10.1 0 No Yes 4 5 1 2
R:R:E199 R:R:S266 2.87 0 No No 4 5 1 2
R:R:W255 R:R:Y258 4.82 1 Yes Yes 9 7 2 2
R:R:V286 R:R:Y258 2.52 1 Yes Yes 5 7 1 2
R:R:M265 R:R:T261 3.01 1 Yes Yes 4 4 1 2
R:R:D282 R:R:T261 4.34 1 Yes Yes 4 4 1 2
R:R:L278 R:R:M265 5.65 0 No Yes 4 4 2 1
R:R:K279 R:R:M265 5.76 0 No Yes 4 4 2 1
R:R:D282 R:R:M265 11.09 1 Yes Yes 4 4 1 1
R:R:E269 R:R:L268 3.98 0 Yes Yes 3 2 2 2
R:R:F275 R:R:L268 9.74 0 No Yes 3 2 1 2
R:R:E269 R:R:P270 3.14 0 Yes No 3 3 2 1
R:R:E269 R:R:S272 10.06 0 Yes No 3 4 2 2
R:R:P273 R:R:S272 3.56 0 No No 2 4 1 2
R:R:F275 R:R:K279 12.41 0 No No 3 4 1 2
R:R:K280 R:R:L276 2.82 9 Yes No 2 3 2 1
R:R:D282 R:R:V286 2.92 1 Yes Yes 4 5 1 1
R:R:V286 R:R:Y290 3.79 1 Yes Yes 5 7 1 1
R:R:C293 R:R:Y290 4.03 0 No Yes 8 7 2 1
R:R:E180 R:R:R178 2.33 2 Yes Yes 1 2 1 1
R:R:P25 R:R:T24 1.75 0 No No 8 4 1 2
L:L:E709 R:R:P273 1.57 0 No No 5 2 0 1
R:R:K28 R:R:S30 1.53 8 Yes No 3 4 1 2
L:L:I718 R:R:D27 1.4 0 No No 4 9 0 1
L:L:R717 R:R:K28 1.24 0 No Yes 7 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JZZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.47
Number of Linked Nodes 337
Number of Links 389
Number of Hubs 58
Number of Links mediated by Hubs 215
Number of Communities 11
Number of Nodes involved in Communities 75
Number of Links involved in Communities 102
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 92227
Length Of Smallest Path 3
Average Path Length 15.9992
Length of Longest Path 40
Minimum Path Strength 1.225
Average Path Strength 5.92102
Maximum Path Strength 22.745
Minimum Path Correlation 0.7
Average Path Correlation 0.95222
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 61.3994
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.4058
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • signaling receptor binding   • molecular function activator activity   • G protein-coupled receptor binding   • signaling receptor activator activity   • cytokine receptor binding   • chemokine activity   • molecular function regulator activity   • cytokine activity   • signaling receptor regulator activity   • chemokine receptor binding   • receptor ligand activity   • enzyme regulator activity   • molecular function inhibitor activity   • peptidase regulator activity   • enzyme inhibitor activity   • peptidase inhibitor activity   • endopeptidase regulator activity   • endopeptidase inhibitor activity   • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains   • lymphocyte mediated immunity   • humoral immune response   • response to stimulus   • positive regulation of biological process   • positive regulation of response to stimulus   • complement activation   • humoral immune response mediated by circulating immunoglobulin   • positive regulation of immune response   • leukocyte mediated immunity   • regulation of immune system process   • positive regulation of immune system process   • complement activation, classical pathway   • regulation of biological process
Gene OntologyBiological Process• adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains   • lymphocyte mediated immunity   • humoral immune response   • response to stimulus   • positive regulation of biological process   • positive regulation of response to stimulus   • complement activation   • humoral immune response mediated by circulating immunoglobulin   • positive regulation of immune response   • leukocyte mediated immunity   • regulation of immune system process   • positive regulation of immune system process   • complement activation, classical pathway   • regulation of biological process   • immune response   • biological regulation   • immunoglobulin mediated immune response   • adaptive immune response   • immune effector process   • regulation of response to stimulus   • immune system process   • B cell mediated immunity   • regulation of immune response   • activation of immune response   • cellular response to stimulus   • negative regulation of mononuclear cell migration   • negative regulation of locomotion   • regulation of cell motility   • regulation of cellular process   • negative regulation of biological process   • negative regulation of chemotaxis   • macrophage migration   • taxis   • negative regulation of macrophage chemotaxis   • cell migration   • regulation of mononuclear cell migration   • negative regulation of macrophage migration   • negative regulation of cell migration   • chemotaxis   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • response to external stimulus   • leukocyte migration   • negative regulation of leukocyte migration   • regulation of locomotion   • response to chemical   • negative regulation of response to external stimulus   • negative regulation of cell motility   • negative regulation of leukocyte chemotaxis   • regulation of response to external stimulus   • macrophage chemotaxis   • regulation of macrophage migration   • negative regulation of cellular process   • regulation of cell migration   • myeloid leukocyte migration   • cell motility   • locomotion   • cell chemotaxis   • regulation of macrophage chemotaxis   • negative regulation of response to stimulus   • regulation of chemotaxis   • cellular response to chemical stimulus   • negative regulation of immune system process   • mononuclear cell migration   • cellular process   • leukocyte chemotaxis   • multicellular organismal process   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • positive regulation of cellular process   • regulation of vascular endothelial growth factor production   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • vascular endothelial growth factor production   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • positive regulation of vascular endothelial growth factor production   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • regulation of chemokine production   • chemokine production   • positive regulation of chemokine production   • cell surface receptor signaling pathway   • signaling   • signal transduction   • cell communication   • biological process involved in interspecies interaction between organisms   • response to biotic stimulus   • response to stress   • innate immune response   • response to external biotic stimulus   • response to other organism   • defense response   • defense response to symbiont   • complement activation, GZMK pathway   • defense response to other organism   • disruption of cell in another organism   • disruption of anatomical structure in another organism   • killing of cells of another organism   • cell killing   • inflammatory response   • G protein-coupled receptor signaling pathway   • complement activation, alternative pathway   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • cellular anatomical structure   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell periphery   • protein-containing complex   • plasma membrane protein complex   • membrane
Gene OntologyCellular Component• extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • cellular anatomical structure   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell periphery   • protein-containing complex   • plasma membrane protein complex   • membrane   • plasma membrane   • membrane protein complex   • pore complex   • membrane attack complex   • other organism cell membrane   • other organism part   • opsonin receptor activity   • molecular transducer activity   • complement receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • complement component C5a receptor activity   • immune receptor activity   • G protein-coupled receptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • cellular process   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • multicellular organismal process   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • regulation of vascular endothelial growth factor production   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • vascular endothelial growth factor production   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • positive regulation of vascular endothelial growth factor production   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • cellular component organization   • cell junction organization   • presynapse organization   • synapse organization   • cellular component organization or biogenesis   • immune response   • immune system process   • immune response-regulating cell surface receptor signaling pathway   • complement receptor mediated signaling pathway   • immune response-activating signaling pathway   • immune response-regulating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • positive regulation of immune system process   • cell surface receptor signaling pathway   • immune response-activating cell surface receptor signaling pathway   • regulation of immune response   • activation of immune response   • amyloid-beta clearance   • cell chemotaxis   • chemotaxis   • neutrophil chemotaxis   • response to external stimulus   • neutrophil migration   • granulocyte migration   • leukocyte migration   • cellular response to chemical stimulus   • taxis   • granulocyte chemotaxis   • response to chemical   • myeloid leukocyte migration   • cell migration   • cell motility   • leukocyte chemotaxis   • locomotion   • system process   • nervous system process   • cognition   • cell population proliferation   • positive regulation of cell population proliferation   • positive regulation of epithelial cell proliferation   • regulation of cell population proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of chemotaxis   • positive regulation of cell migration   • positive regulation of neutrophil chemotaxis   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • positive regulation of granulocyte chemotaxis   • regulation of locomotion   • regulation of neutrophil chemotaxis   • regulation of neutrophil migration   • regulation of response to external stimulus   • regulation of granulocyte chemotaxis   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • positive regulation of leukocyte migration   • positive regulation of neutrophil migration   • regulation of chemotaxis   • macrophage migration   • regulation of mononuclear cell migration   • positive regulation of macrophage migration   • macrophage chemotaxis   • regulation of macrophage migration   • positive regulation of mononuclear cell migration   • regulation of macrophage chemotaxis   • mononuclear cell migration   • positive regulation of macrophage chemotaxis   • cellular developmental process   • astrocyte differentiation   • cell development   • astrocyte activation   • glial cell development   • multicellular organism development   • neurogenesis   • astrocyte development   • gliogenesis   • cell differentiation   • response to stress   • anatomical structure development   • system development   • developmental process   • defense response   • cell activation   • nervous system development   • central nervous system development   • glial cell differentiation   • glial cell activation   • inflammatory response   • neuroinflammatory response   • regulation of developmental process   • angiogenesis   • regulation of vasculature development   • positive regulation of developmental process   • tube morphogenesis   • regulation of anatomical structure morphogenesis   • blood vessel development   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • positive regulation of angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • complement component C5a signaling pathway   • G protein-coupled receptor signaling pathway   • phospholipase C-activating G protein-coupled receptor signaling pathway   • mRNA transcription by RNA polymerase II   • RNA metabolic process   • primary metabolic process   • nucleobase-containing compound biosynthetic process   • mRNA transcription   • mRNA metabolic process   • nucleic acid metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • DNA-templated transcription   • nucleic acid biosynthetic process   • transcription by RNA polymerase II   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular defense response   • sensory perception of chemical stimulus   • sensory perception   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to oxygen-containing compound   • response to nitrogen compound   • response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • response to peptidoglycan   • myeloid leukocyte activation   • leukocyte activation   • macrophage activation   • leukocyte activation involved in inflammatory response   • microglial cell activation   • defense response to Gram-positive bacterium   • defense response to bacterium   • apical part of cell   • basal part of cell   • basal plasma membrane   • plasma membrane region   • basolateral plasma membrane   • intracellular anatomical structure   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • cytoplasm   • organelle membrane   • secretory granule membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • cytoplasmic side of membrane   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • synapse   • cell junction   • mu-type opioid receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cation binding   • metal ion binding   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • heart process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • postsynapse   • postsynaptic membrane   • synaptic membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• Anaphylotoxins (complement system)   • G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Anaphylotoxins (complement system)   • G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinC5a-desArg
UniProtP01031
Sequence
>8JZZ_nogp_Chain_L
TLQKKIEEI AAKYKHSVV KKCCYDGAC VNNDETCEQ RAARISLGP 
RCIKAFTEC CVVASQLRA NISHKDMQL G


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP21730
Sequence
>8JZZ_nogp_Chain_R
LNTPVDKTS NTLRVPDIL ALVIFAVVF LVGVLGNAL VVWVTAFEA 
KRTINAIWF LNLAVADFL SCLALPILF TSIVQHHHW PFGGAACSI 
LPSLILLNM YASILLLAT ISADRFLLV FKPIWCQNF RGAGLAWIA 
CAVAWGLAL LLTIPSFLY RVVREEYFP PKVLCGVDY SHDKRRERA 
VAIVRLVLG FLWPLLTLT ICYTFILLR TWSRRATRS TKTLKVVVA 
VVASFFIFW LPYQVTGIM MSFLEPSSP TFLLLKKLD SLCVSFAYI 
NCCINPIIY VVAGQGFQG RLRKS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5O9HAPeptideComplement PeptideC5a1Homo sapiens-NDT9513727-2.72018-01-10doi.org/10.1038/nature25025
6C1QAPeptideComplement PeptideC5a1Homo sapiensPMX53NDT9513727-2.92018-05-30doi.org/10.1038/s41594-018-0067-z
6C1RAPeptideComplement PeptideC5a1Homo sapiensPMX53Avacopan; Na-2.22018-05-30doi.org/10.1038/s41594-018-0067-z
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y64 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-Gi1/β1/γ23.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-3.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensBM213-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC089 peptide-2.82023-03-01doi.org/10.1038/s41422-023-00779-2
8HK5APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ232023-05-10doi.org/10.1038/s41589-023-01339-w
8HK5 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-32023-05-10doi.org/10.1038/s41589-023-01339-w
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-Go/β1/γ23.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HPT (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-3.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQC (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-Go/β1/γ23.312023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZ (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-3.312023-10-18doi.org/10.1016/j.cell.2023.09.020
9KWGAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9KWG (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.152025-11-2610.1101/2025.05.26.656101
9KWXAPeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.132025-11-2610.1101/2025.05.26.656101
9KWX (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.132025-11-2610.1101/2025.05.26.656101
9KX6APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.112025-11-2610.1101/2025.05.26.656101
9KX6 (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.112025-11-2610.1101/2025.05.26.656101
9KXSAPeptideComplement PeptideC5a1Mus musculusEP67-Go/β1/γ23.312025-11-2610.1101/2025.05.26.656101
9KXS (No Gprot) APeptideComplement PeptideC5a1Mus musculusEP67-3.312025-11-2610.1101/2025.05.26.656101
9UMRAPeptideComplement PeptideC5a1Homo sapiensC5a-pep-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9UMR (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-pep-3.152025-11-2610.1101/2025.05.26.656101
9UMXAPeptideComplement PeptideC5a1Homo sapiensEP54-Go/β1/γ23.22025-11-2610.1101/2025.05.26.656101
9UMX (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP54-3.22025-11-2610.1101/2025.05.26.656101
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.542025-01-15To be published
8JZP (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.542025-01-15To be published
9KUGAPeptideComplement PeptideC5a1Homo sapiensEP67-Go/β1/γ23.072025-11-2610.1101/2025.05.26.656101
9KUG (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP67-3.072025-11-2610.1101/2025.05.26.656101




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