psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L2	L:L:L61	17.99	No	No	0	0	0
2	L:L:L2	R:R:F182	6.09	No	Yes	0	0	3
3	L:L:Q3	R:R:Y181	14.65	No	No	0	0	1
4	L:L:C22	L:L:I6	3.27	No	Yes	2	0	0
5	L:L:A26	L:L:I6	3.25	No	Yes	2	0	0
6	L:L:C54	L:L:I6	4.91	No	Yes	2	0	0
7	L:L:I6	R:R:F182	11.3	Yes	Yes	2	0	3
8	L:L:I9	L:L:V57	4.61	No	Yes	0	0	0
9	L:L:A10	L:L:K19	6.42	No	No	0	0	0
10	L:L:V18	L:L:Y13	13.88	No	Yes	0	0	0
11	L:L:A50	L:L:Y13	6.67	No	Yes	0	0	0
12	L:L:K19	L:L:Y23	11.94	No	No	0	0	0
13	L:L:C21	L:L:C47	7.28	No	No	0	0	0
14	L:L:C22	L:L:C54	7.28	No	No	2	0	0
15	L:L:Y23	R:R:F182	7.22	No	Yes	0	0	3
16	L:L:D24	R:R:P25	6.44	No	No	0	0	8
17	L:L:D24	R:R:D27	11.98	No	No	0	0	9
18	L:L:F51	L:L:G25	3.01	Yes	No	0	0	0
19	L:L:A26	R:R:F182	8.32	No	Yes	2	0	3
20	L:L:C27	L:L:N29	6.3	No	Yes	0	0	0
21	L:L:V28	R:R:E180	12.84	No	Yes	0	0	1
22	L:L:D31	L:L:N29	2.69	No	Yes	0	0	0
23	L:L:N29	L:L:R37	6.03	Yes	Yes	8	0	0
24	L:L:N29	R:R:K28	11.19	Yes	Yes	8	0	3
25	L:L:N30	R:R:L276	15.1	No	No	0	0	3
26	L:L:E32	L:L:T33	8.47	No	No	0	0	0
27	L:L:C34	L:L:R37	5.57	No	Yes	0	0	0
28	L:L:C34	L:L:C55	7.28	No	No	0	0	0
29	L:L:A39	L:L:Q36	4.55	No	No	0	0	0
30	L:L:F51	L:L:R37	16.03	Yes	Yes	0	0	0
31	L:L:R37	R:R:K28	21.04	Yes	Yes	8	0	3
32	L:L:A38	L:L:F51	2.77	No	Yes	0	0	0
33	L:L:R40	R:R:T29	9.06	No	No	0	0	5
34	L:L:I41	L:L:L43	5.71	No	No	0	0	0
35	L:L:C47	L:L:L43	7.94	No	No	0	0	0
36	L:L:G44	L:L:P45	4.06	No	No	0	0	0
37	L:L:P45	L:L:R46	5.76	No	No	0	0	0
38	L:L:I48	L:L:K49	2.91	No	No	0	0	0
39	L:L:E53	L:L:T52	2.82	No	No	0	0	0
40	L:L:C55	L:L:R62	2.79	No	No	0	0	0
41	L:L:S59	L:L:V56	3.23	No	No	0	0	0
42	L:L:Q60	L:L:V57	2.87	No	Yes	0	0	0
43	L:L:R62	L:L:S59	6.59	No	No	0	0	0
44	L:L:H67	L:L:I65	3.98	Yes	No	2	0	0
45	L:L:I65	R:R:R178	3.76	No	Yes	2	0	2
46	L:L:S66	R:R:H194	4.18	No	No	0	0	1
47	L:L:H67	R:R:R178	14.67	Yes	Yes	2	0	2
48	L:L:H67	R:R:L187	2.57	Yes	No	2	0	4
49	L:L:H67	R:R:G189	3.18	Yes	No	0	0	4
50	L:L:H67	R:R:D191	17.65	Yes	No	0	0	4
51	L:L:K68	R:R:E199	2.7	No	No	0	0	4
52	L:L:K68	R:R:P270	3.35	No	No	0	0	3
53	L:L:K68	R:R:F275	2.48	No	No	0	0	3
54	L:L:D69	R:R:H100	8.82	No	No	0	0	4
55	L:L:D69	R:R:L187	6.79	No	No	0	0	4
56	L:L:M70	R:R:V190	4.56	No	No	0	0	5
57	L:L:M70	R:R:M265	4.33	No	Yes	0	0	4
58	L:L:L72	L:L:Q71	2.66	Yes	Yes	1	0	0
59	L:L:Q71	R:R:L92	5.32	Yes	No	1	0	6
60	L:L:Q71	R:R:H100	2.47	Yes	No	0	0	4
61	L:L:Q71	R:R:D282	3.92	Yes	Yes	1	0	4
62	L:L:L72	R:R:L92	4.15	Yes	No	1	0	6
63	L:L:L72	R:R:I116	2.85	Yes	No	1	0	6
64	L:L:L72	R:R:L117	4.15	Yes	No	1	0	4
65	L:L:L72	R:R:M120	4.24	Yes	Yes	1	0	7
66	L:L:L72	R:R:V286	5.96	Yes	Yes	1	0	5
67	L:L:L72	R:R:Y290	7.03	Yes	Yes	1	0	7
68	L:L:G73	R:R:L117	5.13	No	No	0	0	4
69	R:R:L22	R:R:T24	8.84	No	No	0	3	4
70	R:R:S30	R:R:V26	3.23	No	No	0	4	5
71	R:R:N31	R:R:T29	5.85	No	No	0	1	5
72	R:R:L33	R:R:T32	2.95	No	No	0	4	4
73	R:R:D37	R:R:L33	12.21	No	No	0	4	4
74	R:R:P36	R:R:R34	2.88	No	No	0	3	2
75	R:R:K280	R:R:R34	9.9	Yes	No	0	2	2
76	R:R:P36	R:R:V35	5.3	No	No	0	3	3
77	R:R:D37	R:R:I96	4.2	No	No	0	4	5
78	R:R:I38	R:R:L41	4.28	No	No	0	5	5
79	R:R:I38	R:R:V42	3.07	No	No	0	5	5
80	R:R:L284	R:R:L39	2.77	No	No	0	4	5
81	R:R:A40	R:R:S283	3.42	No	No	0	6	4
82	R:R:A40	R:R:S287	3.42	No	No	0	6	4
83	R:R:F93	R:R:L41	9.74	No	No	0	7	5
84	R:R:I43	R:R:V47	3.07	No	Yes	0	5	6
85	R:R:I43	R:R:S287	9.29	No	No	0	5	4
86	R:R:I291	R:R:I43	2.94	Yes	No	0	5	5
87	R:R:F44	R:R:L89	3.65	Yes	Yes	0	7	7
88	R:R:F44	R:R:L92	8.53	Yes	No	1	7	6
89	R:R:F44	R:R:V286	3.93	Yes	Yes	1	7	5
90	R:R:F44	R:R:S287	11.89	Yes	No	0	7	4
91	R:R:F44	R:R:Y290	5.16	Yes	Yes	1	7	7
92	R:R:L89	R:R:V47	2.98	Yes	Yes	0	7	6
93	R:R:V47	R:R:Y290	2.52	Yes	Yes	0	6	7
94	R:R:C294	R:R:V47	6.83	Yes	Yes	0	7	6
95	R:R:F48	R:R:L89	7.31	No	Yes	0	6	7
96	R:R:F48	R:R:P90	8.67	No	No	0	6	9
97	R:R:L53	R:R:V50	4.47	No	No	0	4	6
98	R:R:C294	R:R:V50	3.42	Yes	No	0	7	6
99	R:R:G54	R:R:L53	3.42	No	No	0	7	4
100	R:R:D82	R:R:N55	6.73	Yes	No	0	9	9
101	R:R:N55	R:R:P297	11.4	No	No	0	9	9
102	R:R:A79	R:R:V58	3.39	No	No	0	8	8
103	R:R:R310	R:R:W60	12	Yes	No	0	4	4
104	R:R:F307	R:R:V61	10.49	Yes	No	4	9	6
105	R:R:R310	R:R:V61	22.23	Yes	No	4	4	6
106	R:R:L76	R:R:T62	10.32	No	No	0	6	6
107	R:R:E65	R:R:F64	10.49	Yes	No	0	5	4
108	R:R:E65	R:R:R310	23.26	Yes	Yes	4	5	4
109	R:R:E65	R:R:K313	18.9	Yes	No	4	5	4
110	R:R:E65	R:R:S314	5.75	Yes	No	4	5	4
111	R:R:I73	R:R:K67	2.91	Yes	No	0	6	6
112	R:R:K67	R:R:L76	2.82	No	No	0	6	6
113	R:R:R68	R:R:T69	3.88	No	No	0	7	7
114	R:R:K313	R:R:R68	4.95	No	No	0	4	7
115	R:R:I70	R:R:R148	12.53	No	No	0	6	7
116	R:R:G149	R:R:I70	7.05	No	No	0	5	6
117	R:R:I73	R:R:N77	2.83	Yes	Yes	3	6	9
118	R:R:A153	R:R:I73	3.25	No	Yes	0	7	6
119	R:R:I73	R:R:W154	17.62	Yes	No	3	6	3
120	R:R:T129	R:R:W74	8.49	No	Yes	0	6	7
121	R:R:I130	R:R:W74	3.52	No	Yes	0	8	7
122	R:R:D133	R:R:W74	18.98	No	Yes	0	8	7
123	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
124	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
125	R:R:C157	R:R:W74	2.61	No	Yes	0	6	7
126	R:R:F75	R:R:Y300	14.44	No	Yes	0	8	9
127	R:R:L126	R:R:N77	4.12	No	Yes	3	7	9
128	R:R:N77	R:R:W154	9.04	Yes	No	3	9	3
129	R:R:C157	R:R:N77	11.02	No	Yes	3	6	9
130	R:R:N77	R:R:W161	4.52	Yes	Yes	0	9	9
131	R:R:L78	R:R:S123	3	Yes	No	0	9	9
132	R:R:L126	R:R:L78	4.15	No	Yes	3	7	9
133	R:R:L127	R:R:L78	4.15	No	Yes	3	8	9
134	R:R:I130	R:R:L78	4.28	No	Yes	0	8	9
135	R:R:L78	R:R:N296	8.24	Yes	Yes	3	9	9
136	R:R:L78	R:R:Y300	4.69	Yes	Yes	3	9	9
137	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
138	R:R:D82	R:R:S123	2.94	Yes	No	0	9	9
139	R:R:C293	R:R:D82	6.22	No	Yes	0	8	9
140	R:R:D82	R:R:N296	8.08	Yes	Yes	0	9	9
141	R:R:F83	R:R:L87	10.96	No	No	0	8	4
142	R:R:L84	R:R:N119	13.73	No	No	0	6	9
143	R:R:N119	R:R:S85	4.47	No	No	0	9	6
144	R:R:C86	R:R:L89	3.17	No	Yes	0	5	7
145	R:R:A88	R:R:I116	4.87	No	No	0	6	6
146	R:R:I91	R:R:L112	7.14	No	No	0	6	5
147	R:R:F93	R:R:V97	2.62	No	No	0	7	3
148	R:R:S95	R:R:W102	2.47	No	Yes	0	4	8
149	R:R:H100	R:R:I96	2.65	No	No	0	4	5
150	R:R:Q98	R:R:V97	2.87	No	No	0	4	3
151	R:R:H101	R:R:Q98	2.47	Yes	No	0	4	4
152	R:R:H99	R:R:K185	5.24	No	No	0	2	3
153	R:R:H101	R:R:P103	9.15	Yes	No	0	4	3
154	R:R:H101	R:R:K185	10.48	Yes	No	0	4	3
155	R:R:H101	R:R:V186	4.15	Yes	No	0	4	6
156	R:R:F104	R:R:W102	19.04	No	Yes	0	7	8
157	R:R:C109	R:R:W102	6.53	Yes	Yes	7	9	8
158	R:R:C188	R:R:W102	7.84	No	Yes	7	9	8
159	R:R:A108	R:R:F104	4.16	No	No	0	5	7
160	R:R:C109	R:R:R175	4.18	Yes	Yes	0	9	5
161	R:R:C109	R:R:V177	3.42	Yes	No	7	9	4
162	R:R:C109	R:R:C188	7.28	Yes	No	7	9	9
163	R:R:R175	R:R:S110	2.64	Yes	No	0	5	6
164	R:R:I111	R:R:L115	2.85	No	No	0	4	5
165	R:R:L112	R:R:P113	3.28	No	No	0	5	6
166	R:R:P113	R:R:R175	11.53	No	Yes	0	6	5
167	R:R:S114	R:R:S171	6.52	No	No	0	5	5
168	R:R:F172	R:R:S114	13.21	No	No	0	4	5
169	R:R:I116	R:R:Y290	8.46	No	Yes	1	6	7
170	R:R:L117	R:R:M120	2.83	No	Yes	1	4	7
171	R:R:L118	R:R:W161	3.42	No	Yes	0	5	9
172	R:R:L118	R:R:L165	4.15	No	No	0	5	4
173	R:R:L118	R:R:T168	4.42	No	No	0	5	6
174	R:R:M120	R:R:W255	4.65	Yes	Yes	1	7	9
175	R:R:M120	R:R:Y290	11.97	Yes	Yes	1	7	7
176	R:R:L167	R:R:Y121	7.03	No	No	0	4	7
177	R:R:R206	R:R:Y121	8.23	No	No	0	6	7
178	R:R:A122	R:R:W161	7.78	No	Yes	0	6	9
179	R:R:I124	R:R:P214	3.39	No	Yes	0	8	9
180	R:R:F251	R:R:I124	5.02	Yes	No	1	9	8
181	R:R:I124	R:R:W255	14.09	No	Yes	1	8	9
182	R:R:L125	R:R:L163	2.77	No	No	0	6	4
183	R:R:C157	R:R:L126	3.17	No	No	3	6	7
184	R:R:L127	R:R:Y300	3.52	No	Yes	3	8	9
185	R:R:I130	R:R:R134	6.26	No	No	0	8	9
186	R:R:L218	R:R:S131	6.01	No	No	0	8	9
187	R:R:C221	R:R:S131	5.16	No	No	0	6	9
188	R:R:S131	R:R:Y222	10.17	No	Yes	0	9	8
189	R:R:D133	R:R:L137	8.14	No	No	0	8	8
190	R:R:R134	R:R:Y222	9.26	No	Yes	0	9	8
191	R:R:R134	R:R:Y300	6.17	No	Yes	0	9	9
192	R:R:F135	R:R:F139	10.72	No	Yes	6	8	7
193	R:R:C221	R:R:F135	8.38	No	No	0	6	8
194	R:R:F135	R:R:F224	5.36	No	No	6	8	3
195	R:R:C144	R:R:L137	3.17	No	No	0	5	8
196	R:R:F139	R:R:V138	3.93	Yes	No	6	7	8
197	R:R:I225	R:R:V138	9.22	No	No	0	8	8
198	R:R:R228	R:R:V138	2.62	No	No	6	5	8
199	R:R:F139	R:R:F224	7.5	Yes	No	6	7	3
200	R:R:F139	R:R:R228	9.62	Yes	No	6	7	5
201	R:R:K140	R:R:W143	23.21	No	No	0	6	5
202	R:R:I142	R:R:W143	7.05	No	No	0	5	5
203	R:R:F147	R:R:W143	12.03	No	No	0	4	5
204	R:R:A150	R:R:W154	2.59	No	No	0	3	3
205	R:R:L167	R:R:L209	5.54	No	No	0	4	4
206	R:R:I169	R:R:P170	3.39	No	No	0	3	8
207	R:R:I169	R:R:L173	2.85	No	No	0	3	4
208	R:R:P170	R:R:V202	5.3	No	Yes	5	8	5
209	R:R:P170	R:R:R206	4.32	No	No	5	8	6
210	R:R:R175	R:R:S171	2.64	Yes	No	0	5	5
211	R:R:L173	R:R:Y174	4.69	No	No	0	4	4
212	R:R:Y174	R:R:Y192	13.9	No	Yes	5	4	5
213	R:R:R198	R:R:Y174	8.23	Yes	No	5	3	4
214	R:R:R175	R:R:V190	3.92	Yes	No	0	5	5
215	R:R:D191	R:R:V176	13.15	No	No	0	4	4
216	R:R:C188	R:R:V177	6.83	No	No	7	9	4
217	R:R:L187	R:R:R178	9.72	No	Yes	2	4	2
218	R:R:E179	R:R:Y181	12.35	No	No	0	2	1
219	R:R:E179	R:R:V186	4.28	No	No	0	2	6
220	R:R:E180	R:R:F182	11.66	Yes	Yes	2	1	3
221	R:R:E180	R:R:P183	12.58	Yes	Yes	2	1	4
222	R:R:F182	R:R:P183	2.89	Yes	Yes	2	3	4
223	R:R:K185	R:R:P183	6.69	No	Yes	0	3	4
224	R:R:V190	R:R:Y192	6.31	No	Yes	0	5	5
225	R:R:R198	R:R:Y192	4.12	Yes	Yes	5	3	5
226	R:R:E199	R:R:Y192	10.1	No	Yes	0	4	5
227	R:R:V202	R:R:Y192	5.05	Yes	Yes	5	5	5
228	R:R:K196	R:R:S193	3.06	No	No	0	2	4
229	R:R:K196	R:R:R198	9.9	No	Yes	0	2	3
230	R:R:R198	R:R:V202	2.62	Yes	Yes	5	3	5
231	R:R:E199	R:R:S266	2.87	No	No	0	4	5
232	R:R:F267	R:R:R200	13.9	Yes	No	0	4	3
233	R:R:R206	R:R:V202	2.62	No	Yes	5	6	5
234	R:R:A203	R:R:S266	3.42	No	No	0	5	5
235	R:R:I204	R:R:I263	2.94	No	No	10	3	5
236	R:R:F267	R:R:I204	6.28	Yes	No	10	4	3
237	R:R:L207	R:R:Q259	7.99	No	Yes	0	5	8
238	R:R:I263	R:R:L207	5.71	No	No	0	5	5
239	R:R:L209	R:R:V208	2.98	No	No	0	4	4
240	R:R:G210	R:R:P214	4.06	No	Yes	0	6	9
241	R:R:F211	R:R:L212	3.65	Yes	No	0	8	4
242	R:R:F211	R:R:F252	3.22	Yes	No	0	8	5
243	R:R:F211	R:R:L256	6.09	Yes	No	0	8	5
244	R:R:F211	R:R:Q259	14.05	Yes	Yes	0	8	8
245	R:R:P214	R:R:W213	4.05	Yes	No	0	9	5
246	R:R:T217	R:R:W213	6.06	No	No	0	5	5
247	R:R:F251	R:R:L215	3.65	Yes	No	0	9	5
248	R:R:F252	R:R:L215	7.31	No	No	0	5	5
249	R:R:F251	R:R:L218	3.65	Yes	No	0	9	8
250	R:R:V244	R:R:Y222	15.14	No	Yes	0	7	8
251	R:R:V247	R:R:Y222	10.09	No	Yes	0	7	8
252	R:R:V248	R:R:Y222	5.05	No	Yes	0	7	8
253	R:R:L227	R:R:T223	2.95	No	No	0	4	2
254	R:R:L226	R:R:T240	2.95	No	No	0	5	7
255	R:R:L226	R:R:L241	4.15	No	No	0	5	6
256	R:R:L226	R:R:V244	11.92	No	No	0	5	7
257	R:R:T229	R:R:W230	3.64	No	Yes	0	8	4
258	R:R:T229	R:R:T235	3.14	No	No	0	8	4
259	R:R:R236	R:R:W230	24.99	No	Yes	11	5	4
260	R:R:T238	R:R:W230	3.64	No	Yes	11	5	4
261	R:R:L241	R:R:W230	3.42	No	Yes	0	6	4
262	R:R:R232	R:R:S231	3.95	No	No	0	5	4
263	R:R:R236	R:R:T238	2.59	No	No	11	5	5
264	R:R:K239	R:R:Q305	4.07	No	No	0	7	6
265	R:R:L241	R:R:V245	2.98	No	No	0	6	4
266	R:R:V247	R:R:Y300	2.52	No	Yes	0	7	9
267	R:R:F254	R:R:S250	5.28	Yes	No	0	8	6
268	R:R:F251	R:R:W255	9.02	Yes	Yes	1	9	9
269	R:R:F251	R:R:N292	4.83	Yes	No	1	9	9
270	R:R:F254	R:R:I253	3.77	Yes	No	1	8	5
271	R:R:F288	R:R:I253	2.51	Yes	No	1	8	5
272	R:R:F254	R:R:F288	10.72	Yes	Yes	1	8	8
273	R:R:F254	R:R:I291	20.09	Yes	Yes	1	8	5
274	R:R:F254	R:R:N292	4.83	Yes	No	1	8	9
275	R:R:W255	R:R:Y258	4.82	Yes	Yes	1	9	7
276	R:R:Q259	R:R:W255	4.38	Yes	Yes	1	8	9
277	R:R:N292	R:R:W255	9.04	No	Yes	1	9	9
278	R:R:L256	R:R:P257	3.28	No	No	0	5	9
279	R:R:F288	R:R:P257	7.22	Yes	No	0	8	9
280	R:R:Q259	R:R:Y258	6.76	Yes	Yes	1	8	7
281	R:R:V286	R:R:Y258	2.52	Yes	Yes	1	5	7
282	R:R:A289	R:R:Y258	2.67	No	Yes	0	8	7
283	R:R:G262	R:R:T261	3.64	No	Yes	0	5	4
284	R:R:M265	R:R:T261	3.01	Yes	Yes	1	4	4
285	R:R:D282	R:R:T261	4.34	Yes	Yes	1	4	4
286	R:R:C285	R:R:T261	8.45	No	Yes	0	6	4
287	R:R:F267	R:R:I263	5.02	Yes	No	10	4	5
288	R:R:L268	R:R:M264	4.24	Yes	No	0	2	4
289	R:R:L278	R:R:M264	2.83	No	No	0	4	4
290	R:R:L278	R:R:M265	5.65	No	Yes	0	4	4
291	R:R:K279	R:R:M265	5.76	No	Yes	0	4	4
292	R:R:D282	R:R:M265	11.09	Yes	Yes	1	4	4
293	R:R:F267	R:R:S266	2.64	Yes	No	0	4	5
294	R:R:E269	R:R:L268	3.98	Yes	Yes	0	3	2
295	R:R:L268	R:R:T274	7.37	Yes	No	0	2	1
296	R:R:F275	R:R:L268	9.74	No	Yes	0	3	2
297	R:R:E269	R:R:P270	3.14	Yes	No	0	3	3
298	R:R:E269	R:R:S271	2.87	Yes	No	0	3	4
299	R:R:E269	R:R:S272	10.06	Yes	No	0	3	4
300	R:R:P273	R:R:S272	3.56	No	No	0	2	4
301	R:R:S272	R:R:T274	4.8	No	No	0	4	1
302	R:R:F275	R:R:K279	12.41	No	No	0	3	4
303	R:R:K280	R:R:L276	2.82	Yes	No	0	2	3
304	R:R:L277	R:R:L281	2.77	No	No	9	1	5
305	R:R:D282	R:R:V286	2.92	Yes	Yes	1	4	5
306	R:R:V286	R:R:Y290	3.79	Yes	Yes	1	5	7
307	R:R:F288	R:R:I291	3.77	Yes	Yes	1	8	5
308	R:R:C293	R:R:Y290	4.03	No	Yes	0	8	7
309	R:R:C294	R:R:I291	3.27	Yes	Yes	0	7	5
310	R:R:C294	R:R:I295	3.27	Yes	No	0	7	7
311	R:R:N296	R:R:P297	9.77	Yes	No	0	9	9
312	R:R:N296	R:R:Y300	6.98	Yes	Yes	3	9	9
313	R:R:I299	R:R:Y300	7.25	No	Yes	0	7	9
314	R:R:F307	R:R:V301	11.8	Yes	No	0	9	6
315	R:R:Q305	R:R:Q308	7.68	No	No	0	6	8
316	R:R:F307	R:R:R310	3.21	Yes	Yes	4	9	4
317	R:R:F307	R:R:L311	18.27	Yes	No	0	9	6
318	R:R:K313	R:R:R310	2.48	No	Yes	4	4	4
319	R:R:R310	R:R:S314	10.54	Yes	No	4	4	4
320	R:R:F172	R:R:L115	2.44	No	No	0	4	5
321	R:R:F147	R:R:N146	2.42	No	No	0	4	5
322	L:L:K12	L:L:Y13	2.39	No	Yes	0	0	0
323	R:R:Q145	R:R:R148	2.34	No	No	0	5	7
324	R:R:E180	R:R:R178	2.33	Yes	Yes	2	1	2
325	R:R:L125	R:R:W213	2.28	No	No	0	6	5
326	R:R:N119	R:R:W161	2.26	No	Yes	0	9	9
327	R:R:R228	R:R:R232	2.13	No	No	0	5	5
328	R:R:G105	R:R:G106	2.11	No	No	0	7	3
329	R:R:C86	R:R:G51	1.96	No	No	0	5	8
330	R:R:C109	R:R:G106	1.96	Yes	No	0	9	3
331	R:R:P183	R:R:P184	1.95	Yes	No	0	4	5
332	R:R:A128	R:R:P214	1.87	No	Yes	0	7	9
333	R:R:A66	R:R:A72	1.79	No	No	0	5	7
334	R:R:A122	R:R:A164	1.79	No	No	0	6	7
335	R:R:P297	R:R:V58	1.77	No	No	0	9	8
336	R:R:P25	R:R:T24	1.75	No	No	0	8	4
337	L:L:G44	L:L:L43	1.71	No	No	0	0	0
338	R:R:G162	R:R:L165	1.71	No	No	0	4	4
339	R:R:A79	R:R:V59	1.7	No	No	0	8	7
340	R:R:A303	R:R:V243	1.7	No	No	0	6	7
341	R:R:A249	R:R:V245	1.7	No	No	0	4	4
342	L:L:A38	L:L:T52	1.68	No	No	0	0	0
343	R:R:A66	R:R:T62	1.68	No	No	0	5	6
344	R:R:K140	R:R:P141	1.67	No	No	0	6	8
345	R:R:L284	R:R:P36	1.64	No	No	0	4	3
346	R:R:A153	R:R:I70	1.62	No	No	0	7	6
347	R:R:C144	R:R:K140	1.62	No	No	0	5	6
348	R:R:A246	R:R:I299	1.62	No	No	0	5	7
349	L:L:V56	L:L:V57	1.6	No	Yes	0	0	0
350	R:R:V301	R:R:V58	1.6	No	No	0	6	8
351	R:R:V59	R:R:V80	1.6	No	No	0	7	5
352	R:R:S95	R:R:T94	1.6	No	No	0	4	3
353	R:R:S237	R:R:T240	1.6	No	No	0	7	7
354	R:R:V243	R:R:V247	1.6	No	No	0	7	7
355	R:R:C144	R:R:L136	1.59	No	No	0	5	5
356	R:R:T219	R:R:V248	1.59	No	No	0	4	7
357	R:R:T261	R:R:V260	1.59	Yes	No	0	4	6
358	R:R:A160	R:R:L125	1.58	No	No	0	6	6
359	L:L:E32	R:R:P273	1.57	No	No	0	0	2
360	R:R:T219	R:R:T223	1.57	No	No	0	4	2
361	L:L:I6	L:L:V57	1.54	Yes	Yes	0	0	0
362	R:R:I298	R:R:V50	1.54	No	No	0	7	6
363	R:R:I155	R:R:V159	1.54	No	No	0	2	1
364	R:R:I298	R:R:V302	1.54	No	No	0	7	6
365	R:R:K28	R:R:S30	1.53	Yes	No	0	3	4
366	R:R:F307	R:R:G304	1.51	Yes	No	0	9	8
367	L:L:K49	L:L:T52	1.5	No	No	0	0	0
368	R:R:L39	R:R:V42	1.49	No	No	0	5	5
369	R:R:L167	R:R:V205	1.49	No	No	0	4	3
370	L:L:L61	L:L:T1	1.47	No	No	0	0	0
371	R:R:N71	R:R:T69	1.46	No	No	0	7	7
372	R:R:K239	R:R:K242	1.44	No	No	0	7	6
373	R:R:I220	R:R:L216	1.43	No	No	0	3	2
374	L:L:Q36	L:L:T33	1.42	No	No	0	0	0
375	R:R:K280	R:R:L277	1.41	Yes	No	9	2	1
376	R:R:K280	R:R:L281	1.41	Yes	No	9	2	5
377	L:L:C21	L:L:F51	1.4	No	Yes	0	0	0
378	L:L:I41	R:R:D27	1.4	No	No	0	0	9
379	R:R:A45	R:R:F93	1.39	No	No	0	3	7
380	L:L:H15	L:L:V18	1.38	No	No	0	0	0
381	R:R:A201	R:R:R197	1.38	No	No	0	4	1
382	L:L:E7	L:L:I6	1.37	No	Yes	0	0	0
383	L:L:K4	L:L:Q3	1.36	No	No	0	0	0
384	L:L:R40	R:R:K28	1.24	No	Yes	0	0	3
385	R:R:F307	R:R:L57	1.22	Yes	No	0	9	5
386	R:R:F83	R:R:L84	1.22	No	No	0	8	6
387	R:R:F147	R:R:L152	1.22	No	No	0	4	3
388	L:L:I9	L:L:Y13	1.21	No	Yes	0	0	0
389	R:R:R197	R:R:R200	1.07	No	No	0	1	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:I6	4.27333	6	2	0
2	L:L:Y13	6.0375	4	0	0
3	L:L:N29	6.5525	4	8	0
4	L:L:R37	12.1675	4	8	0
5	L:L:F51	5.8025	4	0	0
6	L:L:V57	2.655	4	0	0
7	L:L:H67	8.41	5	2	0
8	L:L:Q71	3.5925	4	1	0
9	L:L:L72	4.43429	7	1	0
10	R:R:K28	8.75	4	8	3
11	R:R:F44	6.632	5	1	7
12	R:R:V47	3.85	4	0	6
13	R:R:E65	14.6	4	4	5
14	R:R:I73	6.6525	4	3	6
15	R:R:W74	6.89667	6	0	7
16	R:R:N77	6.306	5	3	9
17	R:R:L78	4.75167	6	3	9
18	R:R:D82	5.9925	4	0	9
19	R:R:L89	4.2775	4	0	7
20	R:R:H101	6.5625	4	0	4
21	R:R:W102	8.97	4	7	8
22	R:R:C109	4.674	5	7	9
23	R:R:M120	5.9225	4	1	7
24	R:R:F139	7.9425	4	6	7
25	R:R:W161	4.114	5	0	9
26	R:R:R175	4.982	5	0	5
27	R:R:R178	7.62	4	2	2
28	R:R:E180	9.8525	4	2	1
29	R:R:F182	7.91333	6	2	3
30	R:R:P183	6.0275	4	2	4
31	R:R:Y192	7.896	5	5	5
32	R:R:R198	6.2175	4	5	3
33	R:R:V202	3.8975	4	5	5
34	R:R:F211	6.7525	4	0	8
35	R:R:P214	3.3425	4	0	9
36	R:R:Y222	9.942	5	0	8
37	R:R:W230	8.9225	4	11	4
38	R:R:F251	5.234	5	1	9
39	R:R:F254	8.938	5	1	8
40	R:R:W255	7.66667	6	1	9
41	R:R:Y258	4.1925	4	1	7
42	R:R:Q259	8.295	4	1	8
43	R:R:T261	4.206	5	1	4
44	R:R:M265	5.968	5	1	4
45	R:R:F267	6.96	4	10	4
46	R:R:L268	6.3325	4	0	2
47	R:R:E269	5.0125	4	0	3
48	R:R:K280	3.885	4	9	2
49	R:R:D282	5.5675	4	1	4
50	R:R:V286	3.824	5	1	5
51	R:R:F288	6.055	4	1	8
52	R:R:Y290	6.13714	7	1	7
53	R:R:I291	7.5175	4	1	5
54	R:R:C294	4.1975	4	0	7
55	R:R:N296	8.2675	4	3	9
56	R:R:Y300	6.51	7	3	9
57	R:R:F307	7.75	6	4	9
58	R:R:R310	12.2867	6	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K185	R:R:P183	29.6591	6.69	No	Yes	0	3	4
2	R:R:H101	R:R:K185	27.5003	10.48	Yes	No	0	4	3
3	L:L:I6	R:R:F182	49.896	11.3	Yes	Yes	2	0	3
4	L:L:I6	L:L:V57	46.1524	1.54	Yes	Yes	0	0	0
5	L:L:C21	L:L:F51	14.1135	1.4	No	Yes	0	0	0
6	L:L:F51	L:L:R37	22.0166	16.03	Yes	Yes	0	0	0
7	L:L:C34	L:L:R37	32.834	5.57	No	Yes	0	0	0
8	L:L:C34	L:L:C55	33.8897	7.28	No	No	0	0	0
9	L:L:C55	L:L:R62	34.9401	2.79	No	No	0	0	0
10	L:L:R62	L:L:S59	35.9905	6.59	No	No	0	0	0
11	L:L:S59	L:L:V56	37.0304	3.23	No	No	0	0	0
12	L:L:V56	L:L:V57	38.065	1.6	No	Yes	0	0	0
13	L:L:C21	L:L:C47	12.963	7.28	No	No	0	0	0
14	L:L:C47	L:L:L43	11.8073	7.94	No	No	0	0	0
15	R:R:E180	R:R:F182	53.5501	11.66	Yes	Yes	2	1	3
16	R:R:H101	R:R:Q98	19.7789	2.47	Yes	No	0	4	4
17	R:R:Q98	R:R:V97	18.6547	2.87	No	No	0	4	3
18	R:R:F93	R:R:V97	17.5253	2.62	No	No	0	7	3
19	R:R:F93	R:R:L41	15.2508	9.74	No	No	0	7	5
20	R:R:I38	R:R:L41	14.1056	4.28	No	No	0	5	5
21	R:R:I38	R:R:V42	12.9551	3.07	No	No	0	5	5
22	R:R:L39	R:R:V42	11.7994	1.49	No	No	0	5	5
23	R:R:L284	R:R:L39	10.6384	2.77	No	No	0	4	5
24	R:R:E180	R:R:R178	82.8985	2.33	Yes	Yes	2	1	2
25	R:R:L187	R:R:R178	83.4961	9.72	No	Yes	2	4	2
26	L:L:D69	R:R:L187	89.0983	6.79	No	No	0	0	4
27	L:L:D69	R:R:H100	89.8249	8.82	No	No	0	0	4
28	L:L:Q71	R:R:H100	93.3605	2.47	Yes	No	0	0	4
29	L:L:Q71	R:R:D282	28.5823	3.92	Yes	Yes	1	0	4
30	R:R:D282	R:R:M265	71.3887	11.09	Yes	Yes	1	4	4
31	R:R:L278	R:R:M265	16.7592	5.65	No	Yes	0	4	4
32	R:R:L278	R:R:M264	15.7615	2.83	No	No	0	4	4
33	R:R:L268	R:R:M264	14.8585	4.24	Yes	No	0	2	4
34	R:R:E269	R:R:L268	14.6795	3.98	Yes	Yes	0	3	2
35	R:R:E269	R:R:S272	11.881	10.06	Yes	No	0	3	4
36	R:R:P273	R:R:S272	19.0365	3.56	No	No	0	2	4
37	L:L:E32	R:R:P273	15.2007	1.57	No	No	0	0	2
38	L:L:E32	L:L:T33	11.5519	8.47	No	No	0	0	0
39	R:R:K279	R:R:M265	19.8447	5.76	No	Yes	0	4	4
40	R:R:F275	R:R:K279	18.9417	12.41	No	No	0	3	4
41	R:R:F275	R:R:L268	15.1086	9.74	No	Yes	0	3	2
42	R:R:L268	R:R:T274	13.0657	7.37	Yes	No	0	2	1
43	R:R:S272	R:R:T274	10.9991	4.8	No	No	0	4	1
44	L:L:M70	R:R:M265	36.5039	4.33	No	Yes	0	0	4
45	L:L:M70	R:R:V190	35.6141	4.56	No	No	0	0	5
46	R:R:V190	R:R:Y192	18.0887	6.31	No	Yes	0	5	5
47	L:L:L72	L:L:Q71	64.6966	2.66	Yes	Yes	1	0	0
48	L:L:L72	R:R:M120	16.9488	4.24	Yes	Yes	1	0	7
49	R:R:D282	R:R:V286	55.5061	2.92	Yes	Yes	1	4	5
50	L:L:L72	R:R:Y290	43.8015	7.03	Yes	Yes	1	0	7
51	R:R:V47	R:R:Y290	18.1861	2.52	Yes	Yes	0	6	7
52	R:R:C294	R:R:V47	10.312	6.83	Yes	Yes	0	7	6
53	R:R:C293	R:R:Y290	100	4.03	No	Yes	0	8	7
54	R:R:C293	R:R:D82	99.7604	6.22	No	Yes	0	8	9
55	R:R:D82	R:R:N55	15.9747	6.73	Yes	No	0	9	9
56	R:R:N55	R:R:P297	15.1612	11.4	No	No	0	9	9
57	R:R:D82	R:R:N296	53.4527	8.08	Yes	Yes	0	9	9
58	R:R:N296	R:R:P297	21.3532	9.77	Yes	No	0	9	9
59	R:R:P297	R:R:V58	34.1766	1.77	No	No	0	9	8
60	R:R:V301	R:R:V58	27.1212	1.6	No	No	0	6	8
61	R:R:F307	R:R:V301	25.3442	11.8	Yes	No	0	9	6
62	R:R:F307	R:R:R310	16.3565	3.21	Yes	Yes	4	9	4
63	R:R:D82	R:R:S123	31.1676	2.94	Yes	No	0	9	9
64	R:R:L78	R:R:S123	30.7384	3	Yes	No	0	9	9
65	R:R:L126	R:R:L78	42.2904	4.15	No	Yes	3	7	9
66	R:R:L126	R:R:N77	39.0312	4.12	No	Yes	3	7	9
67	R:R:L78	R:R:N296	33.0315	8.24	Yes	Yes	3	9	9
68	R:R:I130	R:R:L78	27.5135	4.28	No	Yes	0	8	9
69	R:R:I130	R:R:W74	31.3729	3.52	No	Yes	0	8	7
70	R:R:D133	R:R:W74	17.2226	18.98	No	Yes	0	8	7
71	R:R:N77	R:R:W161	27.2739	4.52	Yes	Yes	0	9	9
72	R:R:N119	R:R:W161	10.5937	2.26	No	Yes	0	9	9
73	R:R:R175	R:R:V190	20.8477	3.92	Yes	No	0	5	5
74	R:R:C109	R:R:R175	10.6858	4.18	Yes	Yes	0	9	5
75	R:R:M120	R:R:W255	26.3709	4.65	Yes	Yes	1	7	9
76	R:R:V202	R:R:Y192	10.5647	5.05	Yes	Yes	5	5	5
77	R:R:I124	R:R:P214	10.8648	3.39	No	Yes	0	8	9
78	R:R:F251	R:R:W255	22.1956	9.02	Yes	Yes	1	9	9
79	R:R:F251	R:R:L218	28.3454	3.65	Yes	No	0	9	8
80	R:R:L218	R:R:S131	28.1243	6.01	No	No	0	8	9
81	R:R:C221	R:R:S131	11.1333	5.16	No	No	0	6	9
82	R:R:S131	R:R:Y222	25.4127	10.17	No	Yes	0	9	8
83	R:R:D133	R:R:L137	15.6878	8.14	No	No	0	8	8
84	R:R:C144	R:R:L137	14.1424	3.17	No	No	0	5	8
85	R:R:C144	R:R:K140	11.0359	1.62	No	No	0	5	6
86	R:R:Q259	R:R:W255	13.1236	4.38	Yes	Yes	1	8	9
87	R:R:L207	R:R:Q259	16.8777	7.99	No	Yes	0	5	8
88	R:R:I263	R:R:L207	15.2876	5.71	No	No	0	5	5
89	R:R:F267	R:R:I263	11.9652	5.02	Yes	No	10	4	5
90	R:R:V286	R:R:Y258	25.6075	2.52	Yes	Yes	1	5	7
91	R:R:Q259	R:R:Y258	12.526	6.76	Yes	Yes	1	8	7
92	R:R:V244	R:R:Y222	15.8563	15.14	No	Yes	0	7	8
93	R:R:L226	R:R:V244	14.5636	11.92	No	No	0	5	7
94	R:R:L226	R:R:L241	10.6542	4.15	No	No	0	5	6
95	R:R:N296	R:R:Y300	11.6309	6.98	Yes	Yes	3	9	9
96	R:R:E180	R:R:P183	27.8268	12.58	Yes	Yes	2	1	4
97	R:R:V286	R:R:Y290	41.0925	3.79	Yes	Yes	1	5	7
98	R:R:M120	R:R:Y290	11.1544	11.97	Yes	Yes	1	7	7
99	R:R:W255	R:R:Y258	11.1676	4.82	Yes	Yes	1	9	7
100	R:R:R134	R:R:Y222	15.0086	9.26	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:L2	R:R:F182	6.09	0	No	Yes	0	3	0	1
L:L:Q3	R:R:Y181	14.65	0	No	No	0	1	0	1
L:L:I6	R:R:F182	11.3	2	Yes	Yes	0	3	0	1
L:L:Y23	R:R:F182	7.22	0	No	Yes	0	3	0	1
L:L:D24	R:R:P25	6.44	0	No	No	0	8	0	1
L:L:D24	R:R:D27	11.98	0	No	No	0	9	0	1
L:L:A26	R:R:F182	8.32	2	No	Yes	0	3	0	1
L:L:V28	R:R:E180	12.84	0	No	Yes	0	1	0	1
L:L:N29	R:R:K28	11.19	8	Yes	Yes	0	3	0	1
L:L:N30	R:R:L276	15.1	0	No	No	0	3	0	1
L:L:R37	R:R:K28	21.04	8	Yes	Yes	0	3	0	1
L:L:R40	R:R:T29	9.06	0	No	No	0	5	0	1
L:L:I65	R:R:R178	3.76	2	No	Yes	0	2	0	1
L:L:S66	R:R:H194	4.18	0	No	No	0	1	0	1
L:L:H67	R:R:R178	14.67	2	Yes	Yes	0	2	0	1
L:L:H67	R:R:L187	2.57	2	Yes	No	0	4	0	1
L:L:H67	R:R:G189	3.18	2	Yes	No	0	4	0	1
L:L:H67	R:R:D191	17.65	2	Yes	No	0	4	0	1
L:L:K68	R:R:E199	2.7	0	No	No	0	4	0	1
L:L:K68	R:R:P270	3.35	0	No	No	0	3	0	1
L:L:K68	R:R:F275	2.48	0	No	No	0	3	0	1
L:L:D69	R:R:H100	8.82	0	No	No	0	4	0	1
L:L:D69	R:R:L187	6.79	0	No	No	0	4	0	1
L:L:M70	R:R:V190	4.56	0	No	No	0	5	0	1
L:L:M70	R:R:M265	4.33	0	No	Yes	0	4	0	1
L:L:Q71	R:R:L92	5.32	1	Yes	No	0	6	0	1
L:L:Q71	R:R:H100	2.47	1	Yes	No	0	4	0	1
L:L:Q71	R:R:D282	3.92	1	Yes	Yes	0	4	0	1
L:L:L72	R:R:L92	4.15	1	Yes	No	0	6	0	1
L:L:L72	R:R:I116	2.85	1	Yes	No	0	6	0	1
L:L:L72	R:R:L117	4.15	1	Yes	No	0	4	0	1
L:L:L72	R:R:M120	4.24	1	Yes	Yes	0	7	0	1
L:L:L72	R:R:V286	5.96	1	Yes	Yes	0	5	0	1
L:L:L72	R:R:Y290	7.03	1	Yes	Yes	0	7	0	1
L:L:G73	R:R:L117	5.13	0	No	No	0	4	0	1
R:R:N31	R:R:T29	5.85	0	No	No	1	5	2	1
R:R:F44	R:R:L92	8.53	1	Yes	No	7	6	2	1
R:R:F44	R:R:V286	3.93	1	Yes	Yes	7	5	2	1
R:R:F44	R:R:Y290	5.16	1	Yes	Yes	7	7	2	1
R:R:V47	R:R:Y290	2.52	0	Yes	Yes	6	7	2	1
R:R:A88	R:R:I116	4.87	0	No	No	6	6	2	1
R:R:H100	R:R:I96	2.65	0	No	No	4	5	1	2
R:R:I116	R:R:Y290	8.46	1	No	Yes	6	7	1	1
R:R:L117	R:R:M120	2.83	1	No	Yes	4	7	1	1
R:R:M120	R:R:W255	4.65	1	Yes	Yes	7	9	1	2
R:R:M120	R:R:Y290	11.97	1	Yes	Yes	7	7	1	1
R:R:R175	R:R:V190	3.92	0	Yes	No	5	5	2	1
R:R:D191	R:R:V176	13.15	0	No	No	4	4	1	2
R:R:L187	R:R:R178	9.72	2	No	Yes	4	2	1	1
R:R:E179	R:R:Y181	12.35	0	No	No	2	1	2	1
R:R:E180	R:R:F182	11.66	2	Yes	Yes	1	3	1	1
R:R:E180	R:R:P183	12.58	2	Yes	Yes	1	4	1	2
R:R:F182	R:R:P183	2.89	2	Yes	Yes	3	4	1	2
R:R:V190	R:R:Y192	6.31	0	No	Yes	5	5	1	2
R:R:E199	R:R:Y192	10.1	0	No	Yes	4	5	1	2
R:R:E199	R:R:S266	2.87	0	No	No	4	5	1	2
R:R:W255	R:R:Y258	4.82	1	Yes	Yes	9	7	2	2
R:R:V286	R:R:Y258	2.52	1	Yes	Yes	5	7	1	2
R:R:M265	R:R:T261	3.01	1	Yes	Yes	4	4	1	2
R:R:D282	R:R:T261	4.34	1	Yes	Yes	4	4	1	2
R:R:L278	R:R:M265	5.65	0	No	Yes	4	4	2	1
R:R:K279	R:R:M265	5.76	0	No	Yes	4	4	2	1
R:R:D282	R:R:M265	11.09	1	Yes	Yes	4	4	1	1
R:R:E269	R:R:L268	3.98	0	Yes	Yes	3	2	2	2
R:R:F275	R:R:L268	9.74	0	No	Yes	3	2	1	2
R:R:E269	R:R:P270	3.14	0	Yes	No	3	3	2	1
R:R:E269	R:R:S272	10.06	0	Yes	No	3	4	2	2
R:R:P273	R:R:S272	3.56	0	No	No	2	4	1	2
R:R:F275	R:R:K279	12.41	0	No	No	3	4	1	2
R:R:K280	R:R:L276	2.82	9	Yes	No	2	3	2	1
R:R:D282	R:R:V286	2.92	1	Yes	Yes	4	5	1	1
R:R:V286	R:R:Y290	3.79	1	Yes	Yes	5	7	1	1
R:R:C293	R:R:Y290	4.03	0	No	Yes	8	7	2	1
R:R:E180	R:R:R178	2.33	2	Yes	Yes	1	2	1	1
R:R:P25	R:R:T24	1.75	0	No	No	8	4	1	2
L:L:E32	R:R:P273	1.57	0	No	No	0	2	0	1
R:R:K28	R:R:S30	1.53	8	Yes	No	3	4	1	2
L:L:I41	R:R:D27	1.4	0	No	No	0	9	0	1
L:L:R40	R:R:K28	1.24	0	No	Yes	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JZZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.47
Number of Linked Nodes	337
Number of Links	389
Number of Hubs	58
Number of Links mediated by Hubs	215
Number of Communities	11
Number of Nodes involved in Communities	75
Number of Links involved in Communities	102

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	92227
Length Of Smallest Path	3
Average Path Length	15.9992
Length of Longest Path	40
Minimum Path Strength	1.225
Average Path Strength	5.92102
Maximum Path Strength	22.745
Minimum Path Correlation	0.7
Average Path Correlation	0.95222
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	61.3994
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4058
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Anaphylotoxins (complement system) • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Anaphylotoxins (complement system) • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>8JZZ_nogp_Chain_R L N T P V D K T S N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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