psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R3	R:R:Y181	16.46	No	No	0	0	1
2	L:L:I6	R:R:F182	7.54	No	Yes	0	0	3
3	L:L:E7	L:L:Y23	3.37	No	No	0	0	0
4	L:L:K12	L:L:Q9	4.07	No	No	10	0	0
5	L:L:E53	L:L:Q9	12.74	No	No	10	0	0
6	L:L:I57	L:L:Q9	5.49	No	No	0	0	0
7	L:L:E53	L:L:K12	5.4	No	No	10	0	0
8	L:L:K19	L:L:Y13	5.97	No	No	0	0	0
9	L:L:H15	L:L:V17	5.54	No	No	2	0	0
10	L:L:H15	L:L:P18	6.1	No	No	2	0	0
11	L:L:P18	L:L:V17	3.53	No	No	2	0	0
12	L:L:K20	L:L:V17	4.55	No	No	2	0	0
13	L:L:L46	L:L:P18	3.28	No	No	0	0	0
14	L:L:K19	L:L:Y23	9.55	No	No	0	0	0
15	L:L:K20	R:R:D27	8.3	No	No	2	0	9
16	L:L:K20	R:R:K28	4.31	No	Yes	2	0	3
17	L:L:C21	L:L:C47	7.28	No	No	0	0	0
18	L:L:C21	L:L:F51	6.98	No	No	0	0	0
19	L:L:C22	L:L:C54	7.28	No	No	0	0	0
20	L:L:D24	L:L:R27	10.72	No	No	0	0	0
21	L:L:D24	R:R:D27	14.64	No	No	0	0	9
22	L:L:F51	L:L:G25	9.03	No	No	0	0	0
23	L:L:A26	R:R:F182	6.93	No	Yes	0	0	3
24	L:L:R27	R:R:P183	5.76	No	Yes	0	0	4
25	L:L:N29	L:L:Y31	4.65	Yes	No	0	0	0
26	L:L:E32	L:L:N29	3.94	No	Yes	3	0	0
27	L:L:N29	L:L:R37	6.03	Yes	No	3	0	0
28	L:L:F30	L:L:H67	3.39	No	No	11	0	0
29	L:L:F30	L:L:P69	14.45	No	Yes	11	0	0
30	L:L:E32	L:L:E36	12.69	No	No	3	0	0
31	L:L:E32	L:L:R37	3.49	No	No	3	0	0
32	L:L:E35	L:L:T33	8.47	No	No	3	0	0
33	L:L:E36	L:L:T33	9.88	No	No	3	0	0
34	L:L:C34	L:L:R37	4.18	No	No	0	0	0
35	L:L:C34	L:L:C55	7.28	No	No	0	0	0
36	L:L:E35	L:L:E36	6.34	No	No	3	0	0
37	L:L:C47	L:L:V41	3.42	No	No	0	0	0
38	L:L:V41	R:R:K28	13.66	No	Yes	0	0	3
39	L:L:G44	L:L:P45	4.06	No	No	0	0	0
40	L:L:C47	L:L:G44	3.92	No	No	0	0	0
41	L:L:C54	L:L:E53	9.12	No	No	0	0	0
42	L:L:A58	L:L:R62	4.15	No	No	0	0	0
43	L:L:N59	L:L:R62	6.03	No	No	0	0	0
44	L:L:K63	L:L:N59	11.19	No	No	0	0	0
45	L:L:P66	L:L:S65	3.56	No	No	0	0	0
46	L:L:S65	R:R:R178	7.91	No	No	0	0	2
47	L:L:P66	R:R:D191	11.27	No	No	0	0	4
48	L:L:P66	R:R:H194	6.1	No	No	0	0	1
49	L:L:H67	L:L:P69	4.58	No	Yes	11	0	0
50	L:L:H67	R:R:R178	6.77	No	No	0	0	2
51	L:L:K68	R:R:V190	4.55	No	No	0	0	5
52	L:L:V70	R:R:R175	3.92	No	Yes	0	0	5
53	L:L:L72	L:L:Q71	6.65	Yes	No	4	0	0
54	L:L:G73	L:L:Q71	3.29	No	No	0	0	0
55	L:L:Q71	R:R:L92	3.99	No	No	4	0	6
56	L:L:L72	R:R:L92	5.54	Yes	No	4	0	6
57	L:L:L72	R:R:S95	3	Yes	No	0	0	4
58	L:L:L72	R:R:W102	4.56	Yes	Yes	4	0	8
59	L:L:R74	R:R:L117	3.64	Yes	Yes	0	0	4
60	L:L:R74	R:R:Y258	19.55	Yes	Yes	0	0	7
61	L:L:R74	R:R:G262	4.5	Yes	No	0	0	5
62	L:L:R74	R:R:D282	17.87	Yes	No	0	0	4
63	R:R:L22	R:R:N23	6.87	No	No	0	3	4
64	R:R:P25	R:R:T24	3.5	No	No	0	8	4
65	R:R:T24	R:R:V26	3.17	No	No	0	4	5
66	R:R:D27	R:R:K28	6.91	No	Yes	2	9	3
67	R:R:R34	R:R:T32	5.17	No	No	0	2	4
68	R:R:P36	R:R:V35	5.3	No	Yes	13	3	3
69	R:R:D37	R:R:V35	4.38	No	Yes	0	4	3
70	R:R:K280	R:R:V35	3.04	No	Yes	13	2	3
71	R:R:K280	R:R:P36	5.02	No	No	13	2	3
72	R:R:D37	R:R:S283	4.42	No	Yes	0	4	4
73	R:R:I43	R:R:L39	4.28	No	No	0	5	5
74	R:R:L284	R:R:L39	5.54	No	No	0	4	5
75	R:R:A40	R:R:S283	3.42	No	Yes	14	6	4
76	R:R:A40	R:R:L284	3.15	No	No	14	6	4
77	R:R:A40	R:R:S287	3.42	No	No	0	6	4
78	R:R:F93	R:R:L41	9.74	Yes	No	0	7	5
79	R:R:I43	R:R:S287	7.74	No	No	0	5	4
80	R:R:F44	R:R:V286	3.93	Yes	No	0	7	5
81	R:R:F44	R:R:S287	9.25	Yes	No	0	7	4
82	R:R:F44	R:R:Y290	4.13	Yes	Yes	0	7	7
83	R:R:L89	R:R:V47	2.98	Yes	No	0	7	6
84	R:R:C294	R:R:V47	3.42	No	No	0	7	6
85	R:R:F48	R:R:V52	7.87	No	No	0	6	5
86	R:R:F48	R:R:L89	9.74	No	Yes	0	6	7
87	R:R:F48	R:R:P90	4.33	No	No	0	6	9
88	R:R:C294	R:R:V50	6.83	No	No	0	7	6
89	R:R:C86	R:R:G51	3.92	No	No	0	5	8
90	R:R:G54	R:R:L57	3.42	No	No	0	7	5
91	R:R:D82	R:R:N55	6.73	Yes	No	1	9	9
92	R:R:N55	R:R:P297	14.66	No	No	1	9	9
93	R:R:L57	R:R:V58	2.98	No	No	0	5	8
94	R:R:L311	R:R:L57	5.54	No	No	0	6	5
95	R:R:A79	R:R:V58	3.39	No	No	0	8	8
96	R:R:V59	R:R:V80	3.21	No	No	0	7	5
97	R:R:F64	R:R:W60	8.02	No	No	0	4	4
98	R:R:E65	R:R:V61	12.84	No	No	15	5	6
99	R:R:L311	R:R:V61	5.96	No	No	0	6	6
100	R:R:S314	R:R:V61	3.23	No	No	15	4	6
101	R:R:A72	R:R:T62	3.36	No	No	0	7	6
102	R:R:L76	R:R:T62	5.9	No	No	0	6	6
103	R:R:E65	R:R:R310	23.26	No	No	0	5	4
104	R:R:E65	R:R:S314	11.5	No	No	15	5	4
105	R:R:I73	R:R:K67	10.18	No	No	16	6	6
106	R:R:K67	R:R:W154	3.48	No	Yes	16	6	3
107	R:R:I70	R:R:R148	6.26	No	Yes	0	6	7
108	R:R:G149	R:R:I70	3.53	No	No	0	5	6
109	R:R:N71	R:R:R148	3.62	No	Yes	0	7	7
110	R:R:A153	R:R:I73	4.87	No	No	0	7	6
111	R:R:I73	R:R:W154	16.44	No	Yes	16	6	3
112	R:R:I130	R:R:W74	3.52	Yes	Yes	1	8	7
113	R:R:D133	R:R:W74	18.98	No	Yes	1	8	7
114	R:R:R148	R:R:W74	4	Yes	Yes	1	7	7
115	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
116	R:R:C157	R:R:W74	3.92	No	Yes	0	6	7
117	R:R:F75	R:R:I130	5.02	No	Yes	1	8	8
118	R:R:F75	R:R:R134	4.28	No	No	1	8	9
119	R:R:F75	R:R:Y300	13.41	No	No	0	8	9
120	R:R:N77	R:R:W154	9.04	No	Yes	0	9	3
121	R:R:C157	R:R:N77	9.45	No	No	0	6	9
122	R:R:L78	R:R:S123	3	Yes	No	0	9	9
123	R:R:L126	R:R:L78	11.07	No	Yes	0	7	9
124	R:R:L127	R:R:L78	5.54	No	Yes	1	8	9
125	R:R:I130	R:R:L78	5.71	Yes	Yes	1	8	9
126	R:R:L78	R:R:N296	10.98	Yes	Yes	1	9	9
127	R:R:D82	R:R:S123	7.36	Yes	No	0	9	9
128	R:R:C293	R:R:D82	4.67	No	Yes	0	8	9
129	R:R:D82	R:R:N296	10.77	Yes	Yes	1	9	9
130	R:R:D82	R:R:P297	3.22	Yes	No	1	9	9
131	R:R:L84	R:R:N119	9.61	No	No	0	6	9
132	R:R:N119	R:R:S85	4.47	No	No	0	9	6
133	R:R:C86	R:R:L89	4.76	No	Yes	0	5	7
134	R:R:A88	R:R:I116	4.87	No	No	0	6	6
135	R:R:L89	R:R:Y290	4.69	Yes	Yes	0	7	7
136	R:R:I91	R:R:L112	4.28	No	No	0	6	5
137	R:R:H100	R:R:S95	4.18	No	No	0	4	4
138	R:R:Q98	R:R:V97	5.73	No	No	0	4	3
139	R:R:H99	R:R:K185	9.17	No	Yes	0	2	3
140	R:R:H101	R:R:P103	9.15	No	No	0	4	3
141	R:R:H101	R:R:K185	5.24	No	Yes	0	4	3
142	R:R:H101	R:R:V186	4.15	No	No	0	4	6
143	R:R:F104	R:R:W102	9.02	No	Yes	0	7	8
144	R:R:A108	R:R:W102	3.89	No	Yes	0	5	8
145	R:R:C109	R:R:W102	5.22	No	Yes	4	9	8
146	R:R:C188	R:R:W102	7.84	Yes	Yes	4	9	8
147	R:R:F104	R:R:P103	7.22	No	No	0	7	3
148	R:R:G106	R:R:V177	3.68	No	No	0	3	4
149	R:R:C109	R:R:C188	7.28	No	Yes	4	9	9
150	R:R:F172	R:R:I111	6.28	No	No	0	4	4
151	R:R:L112	R:R:P113	6.57	No	No	0	5	6
152	R:R:P113	R:R:R175	11.53	No	Yes	0	6	5
153	R:R:S114	R:R:T168	6.4	No	No	0	5	6
154	R:R:S114	R:R:S171	6.52	No	No	0	5	5
155	R:R:F172	R:R:S114	7.93	No	No	0	4	5
156	R:R:I116	R:R:Y290	3.63	No	Yes	0	6	7
157	R:R:L117	R:R:Y121	7.03	Yes	No	12	4	7
158	R:R:L117	R:R:T168	5.9	Yes	No	0	4	6
159	R:R:L117	R:R:S171	3	Yes	No	0	4	5
160	R:R:L117	R:R:R206	4.86	Yes	No	12	4	6
161	R:R:L118	R:R:W161	5.69	Yes	Yes	0	5	9
162	R:R:A164	R:R:L118	3.15	No	Yes	0	7	5
163	R:R:L118	R:R:L165	4.15	Yes	No	0	5	4
164	R:R:M120	R:R:Y258	8.38	No	Yes	0	7	7
165	R:R:M120	R:R:Y290	5.99	No	Yes	0	7	7
166	R:R:L167	R:R:Y121	5.86	No	No	0	4	7
167	R:R:R206	R:R:Y121	9.26	No	No	12	6	7
168	R:R:A122	R:R:W161	7.78	No	Yes	0	6	9
169	R:R:I124	R:R:P214	3.39	No	Yes	0	8	9
170	R:R:I124	R:R:W255	12.92	No	Yes	0	8	9
171	R:R:C157	R:R:L126	3.17	No	No	0	6	7
172	R:R:A160	R:R:L126	3.15	No	No	0	6	7
173	R:R:L127	R:R:N296	4.12	No	Yes	1	8	9
174	R:R:A160	R:R:T129	3.36	No	No	0	6	6
175	R:R:I130	R:R:R134	6.26	Yes	No	1	8	9
176	R:R:L218	R:R:S131	3	No	No	0	8	9
177	R:R:C221	R:R:S131	5.16	No	No	0	6	9
178	R:R:S131	R:R:Y222	10.17	No	Yes	0	9	8
179	R:R:D133	R:R:R148	10.72	No	Yes	1	8	7
180	R:R:R134	R:R:Y222	11.32	No	Yes	0	9	8
181	R:R:F135	R:R:F139	17.15	Yes	Yes	7	8	7
182	R:R:C221	R:R:F135	4.19	No	Yes	0	6	8
183	R:R:F135	R:R:F224	4.29	Yes	No	7	8	3
184	R:R:C144	R:R:L137	4.76	No	No	1	5	8
185	R:R:L137	R:R:R148	9.72	No	Yes	1	8	7
186	R:R:F139	R:R:F224	6.43	Yes	No	7	7	3
187	R:R:F139	R:R:R228	7.48	Yes	No	7	7	5
188	R:R:K140	R:R:W143	20.89	No	No	0	6	5
189	R:R:I142	R:R:W143	10.57	No	No	0	5	5
190	R:R:F147	R:R:W143	10.02	No	No	0	4	5
191	R:R:C144	R:R:R148	6.96	No	Yes	1	5	7
192	R:R:F147	R:R:N146	7.25	No	No	0	4	5
193	R:R:L167	R:R:L209	5.54	No	No	0	4	4
194	R:R:I169	R:R:P170	3.39	No	Yes	0	3	8
195	R:R:F172	R:R:I169	5.02	No	No	0	4	3
196	R:R:P170	R:R:V202	5.3	Yes	No	0	8	5
197	R:R:P170	R:R:R206	4.32	Yes	No	0	8	6
198	R:R:R175	R:R:S171	9.22	Yes	No	0	5	5
199	R:R:L173	R:R:Y174	14.07	No	No	0	4	4
200	R:R:R198	R:R:Y174	3.09	No	No	0	3	4
201	R:R:C188	R:R:R175	4.18	Yes	Yes	0	9	5
202	R:R:D191	R:R:V176	11.69	No	No	0	4	4
203	R:R:L187	R:R:R178	3.64	No	No	0	4	2
204	R:R:E179	R:R:E180	5.07	No	Yes	0	2	1
205	R:R:E179	R:R:Y181	23.57	No	No	0	2	1
206	R:R:E180	R:R:F182	10.49	Yes	Yes	8	1	3
207	R:R:E180	R:R:P183	12.58	Yes	Yes	8	1	4
208	R:R:E180	R:R:K185	4.05	Yes	Yes	8	1	3
209	R:R:F182	R:R:P183	5.78	Yes	Yes	8	3	4
210	R:R:K185	R:R:P183	5.02	Yes	Yes	8	3	4
211	R:R:V190	R:R:Y192	12.62	No	No	0	5	5
212	R:R:E199	R:R:Y192	15.71	No	No	0	4	5
213	R:R:V202	R:R:Y192	6.31	No	No	0	5	5
214	R:R:K196	R:R:S193	3.06	No	No	0	2	4
215	R:R:D195	R:R:H194	6.3	No	No	0	3	1
216	R:R:R197	R:R:R200	8.53	No	No	0	1	3
217	R:R:F267	R:R:R200	10.69	No	No	0	4	3
218	R:R:A203	R:R:S266	3.42	No	No	0	5	5
219	R:R:L207	R:R:Q259	5.32	No	No	0	5	8
220	R:R:I263	R:R:L207	7.14	No	No	0	5	5
221	R:R:G210	R:R:P214	4.06	No	Yes	0	6	9
222	R:R:F211	R:R:L212	4.87	No	No	0	8	4
223	R:R:F211	R:R:L256	4.87	No	No	0	8	5
224	R:R:F211	R:R:Q259	11.71	No	No	0	8	8
225	R:R:P214	R:R:W213	6.76	Yes	No	0	9	5
226	R:R:T217	R:R:W213	8.49	No	No	0	5	5
227	R:R:F251	R:R:L215	3.65	Yes	No	0	9	5
228	R:R:F252	R:R:L215	3.65	No	No	0	5	5
229	R:R:F251	R:R:L218	8.53	Yes	No	0	9	8
230	R:R:V244	R:R:Y222	13.88	No	Yes	0	7	8
231	R:R:V247	R:R:Y222	6.31	No	Yes	0	7	8
232	R:R:V248	R:R:Y222	3.79	No	Yes	0	7	8
233	R:R:L226	R:R:T240	4.42	No	No	0	5	7
234	R:R:L226	R:R:L241	5.54	No	No	0	5	6
235	R:R:T229	R:R:T235	3.14	No	No	0	8	4
236	R:R:R236	R:R:W230	22.99	No	Yes	17	5	4
237	R:R:T238	R:R:W230	3.64	No	Yes	17	5	4
238	R:R:R236	R:R:T238	5.17	No	No	17	5	5
239	R:R:K239	R:R:S237	3.06	No	No	0	7	7
240	R:R:S237	R:R:T240	3.2	No	No	0	7	7
241	R:R:I299	R:R:V247	3.07	No	No	0	7	7
242	R:R:I295	R:R:S250	3.1	Yes	No	0	7	6
243	R:R:F251	R:R:W255	12.03	Yes	Yes	6	9	9
244	R:R:F251	R:R:N292	3.62	Yes	No	6	9	9
245	R:R:F252	R:R:L256	7.31	No	No	0	5	5
246	R:R:F254	R:R:I253	6.28	No	No	0	8	5
247	R:R:F254	R:R:I291	26.37	No	Yes	5	8	5
248	R:R:F254	R:R:I295	3.77	No	Yes	5	8	7
249	R:R:W255	R:R:Y258	6.75	Yes	Yes	6	9	7
250	R:R:A289	R:R:W255	3.89	No	Yes	6	8	9
251	R:R:N292	R:R:W255	15.82	No	Yes	6	9	9
252	R:R:L256	R:R:P257	3.28	No	No	0	5	9
253	R:R:Q259	R:R:Y258	7.89	No	Yes	0	8	7
254	R:R:A289	R:R:Y258	6.67	No	Yes	6	8	7
255	R:R:D282	R:R:T261	4.34	No	No	0	4	4
256	R:R:C285	R:R:T261	8.45	No	No	0	6	4
257	R:R:F267	R:R:I263	3.77	No	No	0	4	5
258	R:R:D282	R:R:M265	5.54	No	No	0	4	4
259	R:R:E269	R:R:L268	6.63	Yes	Yes	9	3	2
260	R:R:L268	R:R:S272	4.5	Yes	Yes	9	2	4
261	R:R:L268	R:R:T274	8.84	Yes	No	9	2	1
262	R:R:E269	R:R:P270	3.14	Yes	No	0	3	3
263	R:R:E269	R:R:S271	4.31	Yes	No	0	3	4
264	R:R:E269	R:R:S272	4.31	Yes	Yes	9	3	4
265	R:R:P273	R:R:S272	3.56	No	Yes	0	2	4
266	R:R:S272	R:R:T274	4.8	Yes	No	9	4	1
267	R:R:F275	R:R:L276	7.31	No	No	0	3	3
268	R:R:F275	R:R:K279	16.13	No	No	0	3	4
269	R:R:K280	R:R:L281	4.23	No	No	0	2	5
270	R:R:L284	R:R:S283	4.5	No	Yes	14	4	4
271	R:R:C294	R:R:I291	3.27	No	Yes	0	7	5
272	R:R:I291	R:R:I295	4.42	Yes	Yes	5	5	7
273	R:R:I295	R:R:I298	4.42	Yes	No	5	7	7
274	R:R:N296	R:R:P297	3.26	Yes	No	1	9	9
275	R:R:F307	R:R:Y300	14.44	No	No	0	9	9
276	R:R:F307	R:R:G304	6.02	No	No	0	9	8
277	R:R:K313	R:R:R310	3.71	No	No	0	4	4
278	R:R:L315	R:R:R312	4.86	No	No	0	6	5
279	L:L:T33	R:R:L276	2.95	No	No	0	0	3
280	R:R:L118	R:R:T168	2.95	Yes	No	0	5	6
281	R:R:L215	R:R:T219	2.95	No	No	0	5	4
282	L:L:I57	L:L:I61	2.94	No	No	0	0	0
283	R:R:K279	R:R:M265	2.88	No	No	0	4	4
284	R:R:E199	R:R:S266	2.87	No	No	0	4	5
285	L:L:I61	L:L:L2	2.85	No	No	0	0	0
286	R:R:L278	R:R:M264	2.83	No	No	0	4	4
287	R:R:L278	R:R:M265	2.83	No	No	0	4	4
288	R:R:K140	R:R:L136	2.82	No	No	0	6	5
289	L:L:H15	L:L:S16	2.79	No	No	0	0	0
290	R:R:L76	R:R:N77	2.75	No	No	0	6	9
291	L:L:F51	L:L:V38	2.62	No	No	0	0	0
292	R:R:F93	R:R:V97	2.62	Yes	No	0	7	3
293	R:R:F139	R:R:V138	2.62	Yes	No	7	7	8
294	R:R:R228	R:R:V138	2.62	No	No	7	5	8
295	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
296	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
297	R:R:A150	R:R:W154	2.59	No	Yes	0	3	3
298	R:R:R232	R:R:T235	2.59	No	No	0	5	4
299	R:R:H99	R:R:L33	2.57	No	No	0	2	4
300	R:R:V58	R:R:Y300	2.52	No	No	0	8	9
301	R:R:F135	R:R:I225	2.51	Yes	No	0	8	8
302	R:R:F224	R:R:I220	2.51	No	No	0	3	3
303	R:R:F288	R:R:I291	2.51	No	Yes	0	8	5
304	L:L:R40	R:R:K28	2.48	No	Yes	0	0	3
305	R:R:F275	R:R:L268	2.44	No	Yes	0	3	2
306	L:L:L1	L:L:R3	2.43	No	No	0	0	0
307	R:R:T229	R:R:W230	2.43	No	Yes	0	8	4
308	R:R:F83	R:R:N55	2.42	No	No	0	8	9
309	L:L:L2	R:R:Y181	2.34	No	No	0	0	1
310	R:R:L125	R:R:W213	2.28	No	No	0	6	5
311	R:R:L226	R:R:W230	2.28	No	Yes	0	5	4
312	R:R:N119	R:R:W161	2.26	No	Yes	0	9	9
313	L:L:R62	R:R:F182	2.14	No	Yes	0	0	3
314	R:R:F44	R:R:F93	2.14	Yes	Yes	0	7	7
315	R:R:G105	R:R:G106	2.11	No	No	0	7	3
316	R:R:C109	R:R:G106	1.96	No	No	0	9	3
317	R:R:C188	R:R:G189	1.96	Yes	No	0	9	4
318	R:R:P183	R:R:P184	1.95	Yes	No	0	4	5
319	R:R:A128	R:R:P214	1.87	No	Yes	0	7	9
320	L:L:A10	L:L:C22	1.81	No	No	0	0	0
321	R:R:A66	R:R:A72	1.79	No	No	0	5	7
322	R:R:G54	R:R:L53	1.71	No	No	0	7	4
323	R:R:G162	R:R:L165	1.71	No	No	0	4	4
324	R:R:A79	R:R:V59	1.7	No	No	0	8	7
325	R:R:A303	R:R:V243	1.7	No	No	0	6	7
326	R:R:A249	R:R:V245	1.7	No	No	0	4	4
327	L:L:C55	L:L:T56	1.69	No	No	0	0	0
328	L:L:K68	L:L:P69	1.67	No	Yes	0	0	0
329	L:L:P69	R:R:K279	1.67	Yes	No	0	0	4
330	R:R:K140	R:R:P141	1.67	No	No	0	6	8
331	R:R:L277	R:R:P273	1.64	No	No	0	1	2
332	R:R:G304	R:R:Q305	1.64	No	No	0	8	6
333	R:R:G309	R:R:Q308	1.64	No	No	0	5	8
334	R:R:A107	R:R:I111	1.62	No	No	0	1	4
335	R:R:A246	R:R:I299	1.62	No	No	0	5	7
336	L:L:A50	L:L:K12	1.61	No	No	0	0	0
337	R:R:A303	R:R:K239	1.61	No	No	0	6	7
338	R:R:V301	R:R:V302	1.6	No	No	5	6	6
339	R:R:T240	R:R:V244	1.59	No	No	0	7	7
340	R:R:T261	R:R:V260	1.59	No	No	0	4	6
341	R:R:A63	R:R:L76	1.58	No	No	0	3	6
342	L:L:C55	L:L:N52	1.57	No	No	0	0	0
343	R:R:T219	R:R:T223	1.57	No	No	0	4	2
344	R:R:I96	R:R:S283	1.55	No	Yes	0	5	4
345	R:R:I38	R:R:V42	1.54	No	No	0	5	5
346	R:R:I155	R:R:V159	1.54	No	No	0	2	1
347	R:R:I204	R:R:V205	1.54	No	No	0	3	3
348	R:R:I298	R:R:V301	1.54	No	No	5	7	6
349	R:R:I298	R:R:V302	1.54	No	No	5	7	6
350	L:L:K19	L:L:S16	1.53	No	No	0	0	0
351	R:R:L39	R:R:V42	1.49	No	No	0	5	5
352	R:R:L41	R:R:V42	1.49	No	No	0	5	5
353	R:R:L163	R:R:V159	1.49	No	No	0	4	1
354	R:R:L209	R:R:V205	1.49	No	No	0	4	3
355	R:R:L209	R:R:V208	1.49	No	No	0	4	4
356	R:R:L241	R:R:V245	1.49	No	No	0	6	4
357	R:R:N71	R:R:T69	1.46	No	No	0	7	7
358	R:R:K239	R:R:K242	1.44	No	No	0	7	6
359	R:R:I111	R:R:L115	1.43	No	No	0	4	5
360	R:R:I220	R:R:L216	1.43	No	No	0	3	2
361	R:R:Q98	R:R:T94	1.42	No	No	0	4	3
362	R:R:A45	R:R:F93	1.39	No	Yes	0	3	7
363	R:R:P170	R:R:Y174	1.39	Yes	No	0	8	4
364	R:R:L49	R:R:L53	1.38	No	No	0	4	4
365	R:R:L125	R:R:L163	1.38	No	No	0	6	4
366	R:R:L163	R:R:L167	1.38	No	No	0	4	4
367	R:R:A234	R:R:R233	1.38	No	No	0	2	4
368	L:L:N29	R:R:N31	1.36	Yes	No	0	0	1
369	L:L:E64	L:L:K63	1.35	No	No	0	0	0
370	R:R:R34	R:R:V35	1.31	No	Yes	0	2	3
371	R:R:R68	R:R:T69	1.29	No	No	0	7	7
372	L:L:E8	L:L:Q4	1.27	No	No	0	0	0
373	R:R:F147	R:R:L152	1.22	No	No	0	4	3
374	L:L:L46	L:L:R49	1.21	No	No	0	0	0
375	L:L:Q4	L:L:R3	1.17	No	No	0	0	0
376	R:R:L315	R:R:W60	1.14	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:N29	3.995	4	3	0
2	L:L:P69	5.5925	4	11	0
3	L:L:L72	4.9375	4	4	0
4	L:L:R74	11.39	4	0	0
5	R:R:K28	6.84	4	2	3
6	R:R:V35	3.5075	4	13	3
7	R:R:F44	4.8625	4	0	7
8	R:R:W74	6.36667	6	1	7
9	R:R:L78	7.26	5	1	9
10	R:R:D82	6.55	5	1	9
11	R:R:L89	5.5425	4	0	7
12	R:R:F93	3.9725	4	0	7
13	R:R:W102	6.106	5	4	8
14	R:R:L117	4.886	5	12	4
15	R:R:L118	3.985	4	0	5
16	R:R:I130	5.1275	4	1	8
17	R:R:F135	7.035	4	7	8
18	R:R:F139	8.42	4	7	7
19	R:R:R148	6.88	6	1	7
20	R:R:W154	7.8875	4	16	3
21	R:R:W161	4.58	4	0	9
22	R:R:P170	3.6	4	0	8
23	R:R:R175	7.2125	4	0	5
24	R:R:E180	8.0475	4	8	1
25	R:R:F182	6.576	5	8	3
26	R:R:P183	6.218	5	8	4
27	R:R:K185	5.87	4	8	3
28	R:R:C188	5.315	4	4	9
29	R:R:P214	4.02	4	0	9
30	R:R:Y222	9.094	5	0	8
31	R:R:W230	7.835	4	17	4
32	R:R:F251	6.9575	4	6	9
33	R:R:W255	10.282	5	6	9
34	R:R:Y258	9.848	5	6	7
35	R:R:L268	5.6025	4	9	2
36	R:R:E269	4.5975	4	9	3
37	R:R:S272	4.2925	4	9	4
38	R:R:S283	3.4725	4	14	4
39	R:R:Y290	4.61	4	0	7
40	R:R:I291	9.1425	4	5	5
41	R:R:I295	3.9275	4	5	7
42	R:R:N296	7.2825	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E179	R:R:E180	18.0933	5.07	No	Yes	0	2	1
2	R:R:E179	R:R:Y181	17.012	23.57	No	No	0	2	1
3	L:L:K20	L:L:V17	11.5395	4.55	No	No	2	0	0
4	L:L:K20	R:R:D27	12.2731	8.3	No	No	2	0	9
5	L:L:D24	R:R:D27	24.4733	14.64	No	No	0	0	9
6	L:L:D24	L:L:R27	25.5059	10.72	No	No	0	0	0
7	L:L:R27	R:R:P183	26.5002	5.76	No	Yes	0	0	4
8	L:L:I61	L:L:L2	10.4165	2.85	No	No	0	0	0
9	L:L:L2	R:R:Y181	11.5013	2.34	No	No	0	0	1
10	R:R:D27	R:R:K28	11.1571	6.91	No	Yes	2	9	3
11	L:L:E32	L:L:E36	10.6043	12.69	No	No	3	0	0
12	L:L:E36	L:L:T33	11.7134	9.88	No	No	3	0	0
13	L:L:T33	R:R:L276	13.9733	2.95	No	No	0	0	3
14	R:R:F275	R:R:L276	15.0963	7.31	No	No	0	3	3
15	R:R:F275	R:R:K279	24.8905	16.13	No	No	0	3	4
16	R:R:K279	R:R:M265	36.8368	2.88	No	No	0	4	4
17	R:R:D282	R:R:M265	39.5383	5.54	No	No	0	4	4
18	L:L:R74	R:R:D282	43.1124	17.87	Yes	No	0	0	4
19	L:L:R74	R:R:L117	92.0833	3.64	Yes	Yes	0	0	4
20	R:R:L117	R:R:S171	77.4772	3	Yes	No	0	4	5
21	R:R:R175	R:R:S171	78.2108	9.22	Yes	No	0	5	5
22	R:R:C188	R:R:R175	74.9948	4.18	Yes	Yes	0	9	5
23	R:R:C188	R:R:W102	69.8769	7.84	Yes	Yes	4	9	8
24	R:R:F104	R:R:W102	65.065	9.02	No	Yes	0	7	8
25	R:R:F104	R:R:P103	64.3036	7.22	No	No	0	7	3
26	R:R:H101	R:R:P103	63.5352	9.15	No	No	0	4	3
27	R:R:H101	R:R:K185	61.9776	5.24	No	Yes	0	4	3
28	R:R:E180	R:R:K185	25.2416	4.05	Yes	Yes	8	1	3
29	L:L:P69	R:R:K279	14.5678	1.67	Yes	No	0	0	4
30	L:L:H67	L:L:P69	10.3226	4.58	No	Yes	11	0	0
31	L:L:R62	R:R:F182	10.8546	2.14	No	Yes	0	0	3
32	R:R:P170	R:R:R206	11.689	4.32	Yes	No	0	8	6
33	R:R:L117	R:R:R206	11.8907	4.86	Yes	No	12	4	6
34	L:L:R74	R:R:Y258	100	19.55	Yes	Yes	0	0	7
35	R:R:M120	R:R:Y258	47.6566	8.38	No	Yes	0	7	7
36	R:R:M120	R:R:Y290	46.777	5.99	No	Yes	0	7	7
37	R:R:F44	R:R:Y290	26.6984	4.13	Yes	Yes	0	7	7
38	R:R:F44	R:R:S287	15.9029	9.25	Yes	No	0	7	4
39	R:R:A40	R:R:S287	12.5791	3.42	No	No	0	6	4
40	R:R:A40	R:R:S283	10.3226	3.42	No	Yes	14	6	4
41	R:R:L89	R:R:Y290	20.3984	4.69	Yes	Yes	0	7	7
42	R:R:L89	R:R:V47	13.8481	2.98	Yes	No	0	7	6
43	R:R:C294	R:R:V47	12.7321	3.42	No	No	0	7	6
44	R:R:W255	R:R:Y258	85.5504	6.75	Yes	Yes	6	9	7
45	R:R:F251	R:R:W255	84.2918	12.03	Yes	Yes	6	9	9
46	R:R:F251	R:R:L218	83.4956	8.53	Yes	No	0	9	8
47	R:R:L218	R:R:S131	82.9845	3	No	No	0	8	9
48	R:R:S131	R:R:Y222	77.3173	10.17	No	Yes	0	9	8
49	R:R:R134	R:R:Y222	62.3427	11.32	No	Yes	0	9	8
50	R:R:F75	R:R:R134	18.5453	4.28	No	No	1	8	9
51	R:R:F75	R:R:Y300	20.4089	13.41	No	No	0	8	9
52	R:R:V58	R:R:Y300	16.1046	2.52	No	No	0	8	9
53	R:R:L57	R:R:V58	11.6438	2.98	No	No	0	5	8
54	R:R:I130	R:R:R134	43.0464	6.26	Yes	No	1	8	9
55	R:R:I130	R:R:L78	19.5883	5.71	Yes	Yes	1	8	9
56	R:R:I130	R:R:W74	26.8931	3.52	Yes	Yes	1	8	7
57	R:R:L118	R:R:T168	14.4253	2.95	Yes	No	0	5	6
58	R:R:L117	R:R:T168	16.0385	5.9	Yes	No	0	4	6
59	R:R:L117	R:R:Y121	10.0063	7.03	Yes	No	12	4	7
60	R:R:C221	R:R:S131	10.5104	5.16	No	No	0	6	9
61	R:R:Q259	R:R:Y258	11.5673	7.89	No	Yes	0	8	7
62	R:R:V244	R:R:Y222	19.338	13.88	No	Yes	0	7	8
63	R:R:T240	R:R:V244	18.2533	1.59	No	No	0	7	7
64	R:R:L226	R:R:T240	11.6438	4.42	No	No	0	5	7
65	R:R:C294	R:R:I291	10.4791	3.27	No	Yes	0	7	5
66	R:R:K185	R:R:P183	34.3439	5.02	Yes	Yes	8	3	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R3	R:R:Y181	16.46	0	No	No	0	1	0	1
L:L:I6	R:R:F182	7.54	0	No	Yes	0	3	0	1
L:L:K20	R:R:D27	8.3	2	No	No	0	9	0	1
L:L:K20	R:R:K28	4.31	2	No	Yes	0	3	0	1
L:L:D24	R:R:D27	14.64	0	No	No	0	9	0	1
L:L:A26	R:R:F182	6.93	0	No	Yes	0	3	0	1
L:L:R27	R:R:P183	5.76	0	No	Yes	0	4	0	1
L:L:V41	R:R:K28	13.66	0	No	Yes	0	3	0	1
L:L:S65	R:R:R178	7.91	0	No	No	0	2	0	1
L:L:P66	R:R:D191	11.27	0	No	No	0	4	0	1
L:L:P66	R:R:H194	6.1	0	No	No	0	1	0	1
L:L:H67	R:R:R178	6.77	11	No	No	0	2	0	1
L:L:K68	R:R:V190	4.55	0	No	No	0	5	0	1
L:L:V70	R:R:R175	3.92	0	No	Yes	0	5	0	1
L:L:Q71	R:R:L92	3.99	4	No	No	0	6	0	1
L:L:L72	R:R:L92	5.54	4	Yes	No	0	6	0	1
L:L:L72	R:R:S95	3	4	Yes	No	0	4	0	1
L:L:L72	R:R:W102	4.56	4	Yes	Yes	0	8	0	1
L:L:R74	R:R:L117	3.64	0	Yes	Yes	0	4	0	1
L:L:R74	R:R:Y258	19.55	0	Yes	Yes	0	7	0	1
L:L:R74	R:R:G262	4.5	0	Yes	No	0	5	0	1
L:L:R74	R:R:D282	17.87	0	Yes	No	0	4	0	1
R:R:D27	R:R:K28	6.91	2	No	Yes	9	3	1	1
R:R:H100	R:R:S95	4.18	0	No	No	4	4	2	1
R:R:F104	R:R:W102	9.02	0	No	Yes	7	8	2	1
R:R:A108	R:R:W102	3.89	0	No	Yes	5	8	2	1
R:R:C109	R:R:W102	5.22	4	No	Yes	9	8	2	1
R:R:C188	R:R:W102	7.84	4	Yes	Yes	9	8	2	1
R:R:C109	R:R:C188	7.28	4	No	Yes	9	9	2	2
R:R:P113	R:R:R175	11.53	0	No	Yes	6	5	2	1
R:R:L117	R:R:Y121	7.03	12	Yes	No	4	7	1	2
R:R:L117	R:R:T168	5.9	12	Yes	No	4	6	1	2
R:R:L117	R:R:S171	3	12	Yes	No	4	5	1	2
R:R:L117	R:R:R206	4.86	12	Yes	No	4	6	1	2
R:R:M120	R:R:Y258	8.38	0	No	Yes	7	7	2	1
R:R:R206	R:R:Y121	9.26	12	No	No	6	7	2	2
R:R:R175	R:R:S171	9.22	0	Yes	No	5	5	1	2
R:R:C188	R:R:R175	4.18	4	Yes	Yes	9	5	2	1
R:R:D191	R:R:V176	11.69	0	No	No	4	4	1	2
R:R:L187	R:R:R178	3.64	0	No	No	4	2	2	1
R:R:E179	R:R:E180	5.07	0	No	Yes	2	1	2	2
R:R:E179	R:R:Y181	23.57	0	No	No	2	1	2	1
R:R:E180	R:R:F182	10.49	8	Yes	Yes	1	3	2	1
R:R:E180	R:R:P183	12.58	8	Yes	Yes	1	4	2	1
R:R:E180	R:R:K185	4.05	8	Yes	Yes	1	3	2	2
R:R:F182	R:R:P183	5.78	8	Yes	Yes	3	4	1	1
R:R:K185	R:R:P183	5.02	8	Yes	Yes	3	4	2	1
R:R:V190	R:R:Y192	12.62	0	No	No	5	5	1	2
R:R:D195	R:R:H194	6.3	0	No	No	3	1	2	1
R:R:W255	R:R:Y258	6.75	6	Yes	Yes	9	7	2	1
R:R:A289	R:R:W255	3.89	6	No	Yes	8	9	2	2
R:R:Q259	R:R:Y258	7.89	0	No	Yes	8	7	2	1
R:R:A289	R:R:Y258	6.67	6	No	Yes	8	7	2	1
R:R:D282	R:R:T261	4.34	0	No	No	4	4	1	2
R:R:D282	R:R:M265	5.54	0	No	No	4	4	1	2
R:R:F275	R:R:L276	7.31	0	No	No	3	3	2	1
R:R:F275	R:R:K279	16.13	0	No	No	3	4	2	1
L:L:T33	R:R:L276	2.95	3	No	No	0	3	0	1
R:R:K279	R:R:M265	2.88	0	No	No	4	4	1	2
L:L:R40	R:R:K28	2.48	0	No	Yes	0	3	0	1
L:L:L2	R:R:Y181	2.34	0	No	No	0	1	0	1
L:L:R62	R:R:F182	2.14	0	No	Yes	0	3	0	1
R:R:P183	R:R:P184	1.95	8	Yes	No	4	5	1	2
L:L:P69	R:R:K279	1.67	11	Yes	No	0	4	0	1
L:L:N29	R:R:N31	1.36	3	Yes	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JZP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	344
Number of Links	376
Number of Hubs	42
Number of Links mediated by Hubs	155
Number of Communities	17
Number of Nodes involved in Communities	80
Number of Links involved in Communities	93

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	58631
Length Of Smallest Path	3
Average Path Length	15.6989
Length of Longest Path	37
Minimum Path Strength	1.22
Average Path Strength	7.03925
Maximum Path Strength	20.015
Minimum Path Correlation	0.7
Average Path Correlation	0.947633
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	59.0533
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.8064
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • enzyme regulator activity • molecular function inhibitor activity • peptidase regulator activity • molecular function regulator activity • enzyme inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • lymphocyte mediated immunity • humoral immune response • positive regulation of biological process • positive regulation of response to stimulus • complement activation • humoral immune response mediated by circulating immunoglobulin • positive regulation of immune response • leukocyte mediated immunity • regulation of immune system process • positive regulation of immune system process • complement activation, classical pathway • immune response • immunoglobulin mediated immune response • adaptive immune response • immune effector process • regulation of response to stimulus • immune system process • B cell mediated immunity • regulation of immune response • activation of immune response • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • biological process involved in interspecies interaction between organisms • disruption of cell in another organism • disruption of anatomical structure in another organism • killing of cells of another organism • cell killing • defense response • response to stress • inflammatory response • complement activation, alternative pathway • response to biotic stimulus • innate immune response • response to external biotic stimulus • response to other organism • defense response to symbiont • response to external stimulus • defense response to other organism • pore complex • membrane attack complex • G-protein beta-subunit binding • fibroblast proliferation • opsonin receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement component C5a receptor activity • immune receptor activity • G protein-coupled receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • taxis • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • cognition • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • complement component C5a signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • cellular defense response • response to bacterium • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • apical part of cell • basal part of cell • basal plasma membrane • basolateral plasma membrane • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane
SCOP2	Domain Identifier	• Anaphylotoxins (complement system) • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Anaphylotoxins (complement system) • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>8JZP_nogp_Chain_R L N T P V D K T S N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

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