Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:N710 3.995437
2L:L:P750 5.59254111
3L:L:L753 4.9375448
4L:L:R755 11.39409
5R:R:K28 6.84423
6R:R:V35 3.50754133
7R:R:F44 4.8625407
8R:R:W74 6.36667617
9R:R:L78 7.26519
10R:R:D82 6.55519
11R:R:L89 5.5425407
12R:R:F93 3.9725407
13R:R:W102 6.106548
14R:R:L117 4.8865124
15R:R:L118 3.985405
16R:R:I130 5.1275418
17R:R:F135 7.035478
18R:R:F139 8.42477
19R:R:R148 6.88617
20R:R:W154 7.88754163
21R:R:W161 4.58409
22R:R:P170 3.6408
23R:R:R175 7.2125405
24R:R:E180 8.0475481
25R:R:F182 6.576583
26R:R:P183 6.218584
27R:R:K185 5.87483
28R:R:C188 5.315449
29R:R:P214 4.02409
30R:R:Y222 9.094508
31R:R:W230 7.8354174
32R:R:F251 6.9575469
33R:R:W255 10.282569
34R:R:Y258 9.848567
35R:R:L268 5.6025492
36R:R:E269 4.5975493
37R:R:S272 4.2925494
38R:R:S283 3.47254144
39R:R:Y290 4.61407
40R:R:I291 9.1425455
41R:R:I295 3.9275457
42R:R:N296 7.2825419
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E179 R:R:E180 18.09335.07NoYes021
2R:R:E179 R:R:Y181 17.01223.57NoNo021
3L:L:K701 L:L:V698 11.53954.55NoNo211
4L:L:K701 R:R:D27 12.27318.3NoNo219
5L:L:D705 R:R:D27 24.473314.64NoNo039
6L:L:D705 L:L:R708 25.505910.72NoNo031
7L:L:R708 R:R:P183 26.50025.76NoYes014
8L:L:I742 L:L:L683 10.41652.85NoNo034
9L:L:L683 R:R:Y181 11.50132.34NoNo041
10R:R:D27 R:R:K28 11.15716.91NoYes293
11L:L:E713 L:L:E717 10.604312.69NoNo353
12L:L:E717 L:L:T714 11.71349.88NoNo337
13L:L:T714 R:R:L276 13.97332.95NoNo073
14R:R:F275 R:R:L276 15.09637.31NoNo033
15R:R:F275 R:R:K279 24.890516.13NoNo034
16R:R:K279 R:R:M265 36.83682.88NoNo044
17R:R:D282 R:R:M265 39.53835.54NoNo044
18L:L:R755 R:R:D282 43.112417.87YesNo094
19L:L:R755 R:R:L117 92.08333.64YesYes094
20R:R:L117 R:R:S171 77.47723YesNo045
21R:R:R175 R:R:S171 78.21089.22YesNo055
22R:R:C188 R:R:R175 74.99484.18YesYes095
23R:R:C188 R:R:W102 69.87697.84YesYes498
24R:R:F104 R:R:W102 65.0659.02NoYes078
25R:R:F104 R:R:P103 64.30367.22NoNo073
26R:R:H101 R:R:P103 63.53529.15NoNo043
27R:R:H101 R:R:K185 61.97765.24NoYes043
28R:R:E180 R:R:K185 25.24164.05YesYes813
29L:L:P750 R:R:K279 14.56781.67YesNo014
30L:L:H748 L:L:P750 10.32264.58NoYes1151
31L:L:R743 R:R:F182 10.85462.14NoYes063
32R:R:P170 R:R:R206 11.6894.32YesNo086
33R:R:L117 R:R:R206 11.89074.86YesNo1246
34L:L:R755 R:R:Y258 10019.55YesYes097
35R:R:M120 R:R:Y258 47.65668.38NoYes077
36R:R:M120 R:R:Y290 46.7775.99NoYes077
37R:R:F44 R:R:Y290 26.69844.13YesYes077
38R:R:F44 R:R:S287 15.90299.25YesNo074
39R:R:A40 R:R:S287 12.57913.42NoNo064
40R:R:A40 R:R:S283 10.32263.42NoYes1464
41R:R:L89 R:R:Y290 20.39844.69YesYes077
42R:R:L89 R:R:V47 13.84812.98YesNo076
43R:R:C294 R:R:V47 12.73213.42NoNo076
44R:R:W255 R:R:Y258 85.55046.75YesYes697
45R:R:F251 R:R:W255 84.291812.03YesYes699
46R:R:F251 R:R:L218 83.49568.53YesNo098
47R:R:L218 R:R:S131 82.98453NoNo089
48R:R:S131 R:R:Y222 77.317310.17NoYes098
49R:R:R134 R:R:Y222 62.342711.32NoYes098
50R:R:F75 R:R:R134 18.54534.28NoNo189
51R:R:F75 R:R:Y300 20.408913.41NoNo089
52R:R:V58 R:R:Y300 16.10462.52NoNo089
53R:R:L57 R:R:V58 11.64382.98NoNo058
54R:R:I130 R:R:R134 43.04646.26YesNo189
55R:R:I130 R:R:L78 19.58835.71YesYes189
56R:R:I130 R:R:W74 26.89313.52YesYes187
57R:R:L118 R:R:T168 14.42532.95YesNo056
58R:R:L117 R:R:T168 16.03855.9YesNo046
59R:R:L117 R:R:Y121 10.00637.03YesNo1247
60R:R:C221 R:R:S131 10.51045.16NoNo069
61R:R:Q259 R:R:Y258 11.56737.89NoYes087
62R:R:V244 R:R:Y222 19.33813.88NoYes078
63R:R:T240 R:R:V244 18.25331.59NoNo077
64R:R:L226 R:R:T240 11.64384.42NoNo057
65R:R:C294 R:R:I291 10.47913.27NoYes075
66R:R:K185 R:R:P183 34.34395.02YesYes834
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R684 R:R:Y181 16.46 0 No No 1 1 0 1
L:L:I687 R:R:F182 7.54 0 No Yes 7 3 0 1
L:L:K701 R:R:D27 8.3 2 No No 1 9 0 1
L:L:K701 R:R:K28 4.31 2 No Yes 1 3 0 1
L:L:D705 R:R:D27 14.64 0 No No 3 9 0 1
L:L:A707 R:R:F182 6.93 0 No Yes 6 3 0 1
L:L:R708 R:R:P183 5.76 0 No Yes 1 4 0 1
L:L:V722 R:R:K28 13.66 0 No Yes 4 3 0 1
L:L:S746 R:R:R178 7.91 0 No No 3 2 0 1
L:L:P747 R:R:D191 11.27 0 No No 3 4 0 1
L:L:P747 R:R:H194 6.1 0 No No 3 1 0 1
L:L:H748 R:R:R178 6.77 11 No No 5 2 0 1
L:L:K749 R:R:V190 4.55 0 No No 4 5 0 1
L:L:V751 R:R:R175 3.92 0 No Yes 3 5 0 1
L:L:Q752 R:R:L92 3.99 4 No No 4 6 0 1
L:L:L753 R:R:L92 5.54 4 Yes No 8 6 0 1
L:L:L753 R:R:S95 3 4 Yes No 8 4 0 1
L:L:L753 R:R:W102 4.56 4 Yes Yes 8 8 0 1
L:L:R755 R:R:L117 3.64 0 Yes Yes 9 4 0 1
L:L:R755 R:R:Y258 19.55 0 Yes Yes 9 7 0 1
L:L:R755 R:R:G262 4.5 0 Yes No 9 5 0 1
L:L:R755 R:R:D282 17.87 0 Yes No 9 4 0 1
R:R:D27 R:R:K28 6.91 2 No Yes 9 3 1 1
R:R:H100 R:R:S95 4.18 0 No No 4 4 2 1
R:R:F104 R:R:W102 9.02 0 No Yes 7 8 2 1
R:R:A108 R:R:W102 3.89 0 No Yes 5 8 2 1
R:R:C109 R:R:W102 5.22 4 No Yes 9 8 2 1
R:R:C188 R:R:W102 7.84 4 Yes Yes 9 8 2 1
R:R:C109 R:R:C188 7.28 4 No Yes 9 9 2 2
R:R:P113 R:R:R175 11.53 0 No Yes 6 5 2 1
R:R:L117 R:R:Y121 7.03 12 Yes No 4 7 1 2
R:R:L117 R:R:T168 5.9 12 Yes No 4 6 1 2
R:R:L117 R:R:S171 3 12 Yes No 4 5 1 2
R:R:L117 R:R:R206 4.86 12 Yes No 4 6 1 2
R:R:M120 R:R:Y258 8.38 0 No Yes 7 7 2 1
R:R:R206 R:R:Y121 9.26 12 No No 6 7 2 2
R:R:R175 R:R:S171 9.22 0 Yes No 5 5 1 2
R:R:C188 R:R:R175 4.18 4 Yes Yes 9 5 2 1
R:R:D191 R:R:V176 11.69 0 No No 4 4 1 2
R:R:L187 R:R:R178 3.64 0 No No 4 2 2 1
R:R:E179 R:R:E180 5.07 0 No Yes 2 1 2 2
R:R:E179 R:R:Y181 23.57 0 No No 2 1 2 1
R:R:E180 R:R:F182 10.49 8 Yes Yes 1 3 2 1
R:R:E180 R:R:P183 12.58 8 Yes Yes 1 4 2 1
R:R:E180 R:R:K185 4.05 8 Yes Yes 1 3 2 2
R:R:F182 R:R:P183 5.78 8 Yes Yes 3 4 1 1
R:R:K185 R:R:P183 5.02 8 Yes Yes 3 4 2 1
R:R:V190 R:R:Y192 12.62 0 No No 5 5 1 2
R:R:D195 R:R:H194 6.3 0 No No 3 1 2 1
R:R:W255 R:R:Y258 6.75 6 Yes Yes 9 7 2 1
R:R:A289 R:R:W255 3.89 6 No Yes 8 9 2 2
R:R:Q259 R:R:Y258 7.89 0 No Yes 8 7 2 1
R:R:A289 R:R:Y258 6.67 6 No Yes 8 7 2 1
R:R:D282 R:R:T261 4.34 0 No No 4 4 1 2
R:R:D282 R:R:M265 5.54 0 No No 4 4 1 2
R:R:F275 R:R:L276 7.31 0 No No 3 3 2 1
R:R:F275 R:R:K279 16.13 0 No No 3 4 2 1
L:L:T714 R:R:L276 2.95 3 No No 7 3 0 1
R:R:K279 R:R:M265 2.88 0 No No 4 4 1 2
L:L:R721 R:R:K28 2.48 0 No Yes 8 3 0 1
L:L:L683 R:R:Y181 2.34 0 No No 4 1 0 1
L:L:R743 R:R:F182 2.14 0 No Yes 6 3 0 1
R:R:P183 R:R:P184 1.95 8 Yes No 4 5 1 2
L:L:P750 R:R:K279 1.67 11 Yes No 1 4 0 1
L:L:N710 R:R:N31 1.36 3 Yes No 7 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JZP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.98
Number of Linked Nodes 344
Number of Links 376
Number of Hubs 42
Number of Links mediated by Hubs 155
Number of Communities 17
Number of Nodes involved in Communities 80
Number of Links involved in Communities 93
Path Summary
Number Of Nodes in MetaPath 67
Number Of Links MetaPath 66
Number of Shortest Paths 58631
Length Of Smallest Path 3
Average Path Length 15.6989
Length of Longest Path 37
Minimum Path Strength 1.22
Average Path Strength 7.03925
Maximum Path Strength 20.015
Minimum Path Correlation 0.7
Average Path Correlation 0.947633
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 59.0533
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.8064
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Anaphylotoxins (complement system)   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Anaphylotoxins (complement system)   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinC5a
UniProtP06684
Sequence
>8JZP_nogp_Chain_L
LLRQKIEEQ AAKYKHSVP KKCCYDGAR NFYETCEER VARVGPLCI 
RAFNECCTI ANKIRKESP HKPVQLGR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP21730
Sequence
>8JZP_nogp_Chain_R
LNTPVDKTS NTLRVPDIL ALVIFAVVF LVGVLGNAL VVWVTAFEA 
KRTINAIWF LNLAVADFL SCLALPILF TSIVQHHHW PFGGAACSI 
LPSLILLNM YASILLLAT ISADRFLLV FKPIWCQNF RGAGLAWIA 
CAVAWGLAL LLTIPSFLY RVVREEYFP PKVLCGVDY SHDKRRERA 
VAIVRLVLG FLWPLLTLT ICYTFILLR TWSRRATRS TKTLKVVVA 
VVASFFIFW LPYQVTGIM MSFLEPSSP TFLLLKKLD SLCVSFAYI 
NCCINPIIY VVAGQGFQG RLRKSL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5O9HAPeptideComplement PeptideC5a1Homo sapiens-NDT9513727-2.72018-01-10doi.org/10.1038/nature25025
6C1QAPeptideComplement PeptideC5a1Homo sapiensPMX53NDT9513727-2.92018-05-30doi.org/10.1038/s41594-018-0067-z
6C1RAPeptideComplement PeptideC5a1Homo sapiensPMX53Avacopan; Na-2.22018-05-30doi.org/10.1038/s41594-018-0067-z
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y64 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-Gi1/β1/γ23.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-3.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensBM213-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC089 peptide-2.82023-03-01doi.org/10.1038/s41422-023-00779-2
8HK5APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ232023-05-10doi.org/10.1038/s41589-023-01339-w
8HK5 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-32023-05-10doi.org/10.1038/s41589-023-01339-w
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-Go/β1/γ23.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HPT (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-3.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQC (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-Go/β1/γ23.312023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZ (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-3.312023-10-18doi.org/10.1016/j.cell.2023.09.020
9KWGAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9KWG (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.152025-11-2610.1101/2025.05.26.656101
9KWXAPeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.132025-11-2610.1101/2025.05.26.656101
9KWX (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.132025-11-2610.1101/2025.05.26.656101
9KX6APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.112025-11-2610.1101/2025.05.26.656101
9KX6 (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.112025-11-2610.1101/2025.05.26.656101
9KXSAPeptideComplement PeptideC5a1Mus musculusEP67-Go/β1/γ23.312025-11-2610.1101/2025.05.26.656101
9KXS (No Gprot) APeptideComplement PeptideC5a1Mus musculusEP67-3.312025-11-2610.1101/2025.05.26.656101
9UMRAPeptideComplement PeptideC5a1Homo sapiensC5a-pep-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9UMR (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-pep-3.152025-11-2610.1101/2025.05.26.656101
9UMXAPeptideComplement PeptideC5a1Homo sapiensEP54-Go/β1/γ23.22025-11-2610.1101/2025.05.26.656101
9UMX (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP54-3.22025-11-2610.1101/2025.05.26.656101
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.542025-01-15To be published
8JZP (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.542025-01-15To be published
9KUGAPeptideComplement PeptideC5a1Homo sapiensEP67-Go/β1/γ23.072025-11-2610.1101/2025.05.26.656101
9KUG (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP67-3.072025-11-2610.1101/2025.05.26.656101




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