Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?4 9.214500
2L:L:?5 11.04710
3L:L:?6 14.086510
4R:R:Y44 5.465408
5R:R:F48 5.6447
6R:R:N55 7.63459
7R:R:W74 5.668507
8R:R:D82 8.7625459
9R:R:L89 6.445448
10R:R:D105 4.245407
11R:R:L112 5.3175405
12R:R:I124 5.1125418
13R:R:F139 5.914528
14R:R:R148 9.655437
15R:R:W161 4.075409
16R:R:R175 5.19404
17R:R:P215 2.542508
18R:R:Y223 8.1325409
19R:R:F225 3.345424
20R:R:F252 4.706519
21R:R:F255 4.262509
22R:R:W256 8.31833618
23R:R:Y259 7.975417
24R:R:T262 4.055405
25R:R:Y291 5.052507
26R:R:F308 4.102508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?4 L:L:P3 16.26664.63YesNo000
2L:L:?4 L:L:?5 50.124725.53YesYes000
3L:L:?4 R:R:Y178 18.79198.81YesNo001
4L:L:?5 L:L:?6 16.071728.26YesYes100
5L:L:?5 R:R:L92 22.27593.54YesNo006
6L:L:?5 R:R:I116 27.38114.87YesNo006
7L:L:?5 R:R:L117 25.9474.72YesNo004
8L:L:?5 R:R:Y259 49.7744YesYes107
9L:L:?6 R:R:T262 23.37494.7YesYes005
10R:R:L92 R:R:Y291 22.21363.52NoYes067
11R:R:L89 R:R:Y291 44.02187.03YesYes087
12R:R:L89 R:R:Y44 29.27519.38YesYes088
13R:R:S284 R:R:Y44 11.37965.09NoYes048
14R:R:I116 R:R:Y291 28.16063.63NoYes067
15R:R:F93 R:R:Y44 11.68361.03NoYes078
16R:R:S85 R:R:Y291 46.4775.09NoYes077
17R:R:C294 R:R:S85 38.15283.44NoNo097
18R:R:C294 R:R:D82 36.03277.78NoYes099
19R:R:D82 R:R:N55 29.477816.16YesYes599
20R:R:G51 R:R:N55 22.98525.09NoYes089
21R:R:C295 R:R:G51 20.7563.92NoNo088
22R:R:F48 R:R:L89 11.64466.09YesYes478
23R:R:W256 R:R:Y259 58.20736.75YesYes187
24R:R:F252 R:R:W256 88.9018.02YesYes198
25R:R:F252 R:R:L219 1004.87YesNo098
26R:R:L219 R:R:S131 99.71166.01NoNo089
27R:R:S131 R:R:Y223 84.240112.72NoYes099
28R:R:R134 R:R:Y223 73.20347.2NoYes099
29R:R:F75 R:R:R134 33.16452.14NoNo089
30R:R:F75 R:R:Y301 31.85520.63NoNo089
31R:R:V58 R:R:Y301 27.40453.79NoNo099
32R:R:F308 R:R:V58 20.91972.62YesNo089
33R:R:I130 R:R:R134 48.75295.01NoNo099
34R:R:I130 R:R:W74 47.40453.52NoYes097
35R:R:A153 R:R:W74 30.57685.19NoYes087
36R:R:A153 R:R:I73 29.01013.25NoNo086
37R:R:D133 R:R:W74 15.611813.4NoYes087
38R:R:D133 R:R:R148 10.374110.72NoYes387
39R:R:I73 R:R:W154 20.943112.92NoNo064
40R:R:N77 R:R:W154 19.28295.65NoNo094
41R:R:C157 R:R:N77 10.748212.6NoNo089
42R:R:I116 R:R:L112 10.77947.14NoYes065
43L:L:?4 R:R:T95 10.59241.39YesNo005
44R:R:C109 R:R:Y178 16.76545.38NoNo091
45R:R:C109 R:R:W102 14.723313.06NoNo099
46R:R:F104 R:R:W102 12.665612.03NoNo089
47R:R:D105 R:R:F104 10.59243.58YesNo078
48R:R:L117 R:R:Y121 24.12318.21NoNo047
49R:R:R207 R:R:Y121 22.151210.29NoNo057
50R:R:P170 R:R:R207 20.39754.32NoNo075
51R:R:I169 R:R:P170 14.61423.39NoNo047
52R:R:M120 R:R:Y291 46.89795.99NoYes087
53R:R:M120 R:R:W256 47.26424.65NoYes088
54R:R:I124 R:R:W256 11.309411.74YesYes188
55R:R:I124 R:R:P215 16.33673.39YesYes088
56R:R:N293 R:R:W256 19.12713.56NoYes098
57R:R:C222 R:R:S131 37.70071.72NoNo089
58R:R:C222 R:R:F135 36.2126.98NoNo088
59R:R:F135 R:R:F139 26.328916.08NoYes288
60R:R:F139 R:R:V138 13.90492.62YesNo288
61R:R:L226 R:R:V138 12.22928.94NoNo088
62R:R:F139 R:R:K140 10.74821.24YesNo086
63R:R:Q260 R:R:Y259 10.55343.38NoYes087
64R:R:L208 R:R:Q260 12.4633.99NoNo058
65R:R:V245 R:R:Y223 13.694510.09NoYes079
66R:R:L226 R:R:T230 10.50662.95NoNo088
67R:R:F255 R:R:N293 14.14654.83YesNo099
68R:R:T262 R:R:V279 13.75683.17YesNo054
69R:R:L276 R:R:V279 10.15594.47NoNo014
70L:L:?6 R:R:Y259 12.556517.77YesYes107
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:P3 R:R:E280 6.29 0 No No 0 3 0 1
L:L:?4 R:R:R175 5.71 0 Yes Yes 0 4 0 1
L:L:?4 R:R:Y178 8.81 0 Yes No 0 1 0 1
L:L:?5 R:R:L92 3.54 1 Yes No 0 6 0 1
L:L:?5 R:R:I116 4.87 1 Yes No 0 6 0 1
L:L:?5 R:R:L117 4.72 1 Yes No 0 4 0 1
L:L:?5 R:R:Y259 4 1 Yes Yes 0 7 0 1
L:L:?5 R:R:V287 6.36 1 Yes No 0 5 0 1
L:L:?6 R:R:Y259 17.77 1 Yes Yes 0 7 0 1
L:L:?6 R:R:T262 4.7 1 Yes Yes 0 5 0 1
L:L:?6 R:R:G263 5.46 1 Yes No 0 6 0 1
L:L:?6 R:R:N283 14.24 1 Yes No 0 4 0 1
R:R:L92 R:R:Y291 3.52 0 No Yes 6 7 1 2
R:R:C109 R:R:Y178 5.38 0 No No 9 1 2 1
R:R:I110 R:R:R175 3.76 0 No Yes 7 4 2 1
R:R:L112 R:R:P113 4.93 0 Yes No 5 5 2 2
R:R:I116 R:R:L112 7.14 0 No Yes 6 5 1 2
R:R:P113 R:R:R175 8.65 0 No Yes 5 4 2 1
R:R:I116 R:R:Y291 3.63 0 No Yes 6 7 1 2
R:R:L117 R:R:Y121 8.21 0 No No 4 7 1 2
R:R:W256 R:R:Y259 6.75 1 Yes Yes 8 7 2 1
R:R:Q260 R:R:Y259 3.38 0 No Yes 8 7 2 1
R:R:T262 R:R:V279 3.17 0 Yes No 5 4 1 2
R:R:C286 R:R:T262 6.76 0 No Yes 7 5 2 1
R:R:E280 R:R:K277 4.05 0 No No 3 2 1 2
R:R:R175 R:R:S171 2.64 0 Yes No 4 5 1 2
L:L:?1 R:R:E176 2.29 0 No No 0 3 0 1
R:R:T262 R:R:V261 1.59 0 Yes No 5 6 1 2
R:R:T94 R:R:T95 1.57 0 No No 5 5 2 1
L:L:?4 R:R:T95 1.39 0 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8HPT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.17
Number of Linked Nodes 237
Number of Links 245
Number of Hubs 26
Number of Links mediated by Hubs 102
Number of Communities 5
Number of Nodes involved in Communities 21
Number of Links involved in Communities 24
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 29595
Length Of Smallest Path 3
Average Path Length 12.2835
Length of Longest Path 29
Minimum Path Strength 1.195
Average Path Strength 6.61407
Maximum Path Strength 20.8667
Minimum Path Correlation 0.7
Average Path Correlation 0.923605
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 49.4646
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.4235
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • positive regulation of MAPK cascade   • biological regulation   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • cellular process   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • multicellular organismal process   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • regulation of vascular endothelial growth factor production   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • vascular endothelial growth factor production   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • positive regulation of vascular endothelial growth factor production   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • cellular component organization   • cell junction organization   • presynapse organization   • synapse organization   • cellular component organization or biogenesis   • amyloid-beta clearance   • cell chemotaxis   • chemotaxis   • neutrophil chemotaxis   • response to external stimulus   • neutrophil migration   • granulocyte migration   • leukocyte migration   • cellular response to chemical stimulus   • taxis   • immune system process   • granulocyte chemotaxis   • response to chemical   • myeloid leukocyte migration   • cell migration   • cell motility   • leukocyte chemotaxis   • locomotion   • system process   • nervous system process   • cognition   • cell population proliferation   • positive regulation of cell population proliferation   • positive regulation of epithelial cell proliferation   • regulation of cell population proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of chemotaxis   • positive regulation of cell migration   • positive regulation of neutrophil chemotaxis   • regulation of immune system process   • positive regulation of immune system process   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • positive regulation of granulocyte chemotaxis   • regulation of locomotion   • regulation of neutrophil chemotaxis   • regulation of neutrophil migration   • regulation of response to external stimulus   • regulation of granulocyte chemotaxis   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • positive regulation of leukocyte migration   • positive regulation of neutrophil migration   • regulation of chemotaxis   • macrophage migration   • regulation of mononuclear cell migration   • positive regulation of macrophage migration   • macrophage chemotaxis   • regulation of macrophage migration   • positive regulation of mononuclear cell migration   • regulation of macrophage chemotaxis   • mononuclear cell migration   • positive regulation of macrophage chemotaxis   • cellular developmental process   • astrocyte differentiation   • cell development   • astrocyte activation   • glial cell development   • multicellular organism development   • neurogenesis   • astrocyte development   • gliogenesis   • cell differentiation   • response to stress   • anatomical structure development   • system development   • developmental process   • defense response   • cell activation   • nervous system development   • central nervous system development   • glial cell differentiation   • glial cell activation   • inflammatory response   • neuroinflammatory response   • regulation of developmental process   • angiogenesis   • regulation of vasculature development   • positive regulation of developmental process   • tube morphogenesis   • regulation of anatomical structure morphogenesis   • blood vessel development   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • positive regulation of angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • mRNA transcription by RNA polymerase II   • RNA metabolic process   • primary metabolic process   • nucleobase-containing compound biosynthetic process   • mRNA transcription   • mRNA metabolic process   • nucleic acid metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • DNA-templated transcription   • nucleic acid biosynthetic process   • transcription by RNA polymerase II   • G protein-coupled receptor signaling pathway   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to oxygen-containing compound   • response to nitrogen compound   • response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • response to peptidoglycan   • myeloid leukocyte activation   • leukocyte activation   • macrophage activation   • leukocyte activation involved in inflammatory response   • microglial cell activation   • defense response to Gram-positive bacterium   • defense response to bacterium   • defense response to other organism   • cellular anatomical structure   • apical part of cell   • cell periphery   • basal part of cell   • membrane   • plasma membrane   • basal plasma membrane   • plasma membrane region   • basolateral plasma membrane   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • cytoplasmic vesicle   • organelle
Gene OntologyCellular Component• cellular anatomical structure   • apical part of cell   • cell periphery   • basal part of cell   • membrane   • plasma membrane   • basal plasma membrane   • plasma membrane region   • basolateral plasma membrane   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • cytoplasmic vesicle   • organelle   • intracellular vesicle   • cytoplasm   • intracellular membrane-bounded organelle   • vesicle   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • mu-type opioid receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cation binding   • metal ion binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • protein localization   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • cellular macromolecule localization   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • postsynapse   • postsynaptic membrane   • synapse   • cell junction   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-activating dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeMEA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeMEA
NameN-METHYLPHENYLALANINE
Synonyms
Identifier
FormulaC10 H13 N O2
Molecular Weight179.216
SMILES
PubChem6951134
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6

CodeZAL
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeZAL
Name3-cyclohexyl-D-alanine
Synonyms
Identifier
FormulaC9 H17 N O2
Molecular Weight171.237
SMILES
PubChem736026
Formal Charge0
Total Atoms29
Total Chiral Atoms1
Total Bonds29
Total Aromatic Bonds0

CodeALC
PDB ResiduesL:L:?5
Environment DetailsOpen EMBL-EBI Page
CodeALC
Name3-Cyclohexyl-L-alanine
Synonyms
  • beta-Cyclohexyl-alanine
  • β-Cyclohexyl-alanine
  • 3-Cyclohexyl-L-alanine
  • beta-Cyclohexyl-L-alanine
Identifier
FormulaC9 H17 N O2
Molecular Weight171.237
SMILES
PubChem712421
Formal Charge0
Total Atoms29
Total Chiral Atoms1
Total Bonds29
Total Aromatic Bonds0

CodeDAR
PDB ResiduesL:L:?6
Environment DetailsOpen EMBL-EBI Page
CodeDAR
NameD-arginine
SynonymsD-Arginin
Identifier
FormulaC6 H15 N4 O2
Molecular Weight175.209
SMILES
PubChem1549104
Formal Charge1
Total Atoms27
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30993
Sequence
>8HPT_nogp_Chain_R
GDVAALIIY SVVFLVGVP GNALVVWVT AFEAVNAIW FLNLAVADL 
LSCLALPVL FTTVLNHNY WYFDATACI VLPSLILLN MYASILLLA 
TISADRFLL VFKPIWCQK VRGTGLAWM ACGVAWVLA LLLTIPSFV 
YREAYKAVA ILRLMVGFV LPLLTLNIC YTFLLLRTW SRKATRSTK 
TLKVVMAVV ICFFIFWLP YQVTGVMIA WLPPSSPTL KRVEKLNSL 
CVSLAYINC CVNPIIYVM AGQGFHGRL LRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5A anaphylatoxin-Go/β1/γ23.542025-01-15To be published
8JZP (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5A anaphylatoxin-3.542025-01-15To be published
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-desArg-Go/β1/γ23.312023-10-1810.1016/j.cell.2023.09.020
8JZZ (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-desArg-3.312023-10-1810.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a anaphylatoxin-Go/β1/γ23.212023-10-1810.1016/j.cell.2023.09.020
8IA2 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a anaphylatoxin-3.212023-10-1810.1016/j.cell.2023.09.020
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a anaphylatoxin C-terminal peptide-Go/β1/γ23.392023-10-1810.1016/j.cell.2023.09.020
8HPT (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a anaphylatoxin C-terminal peptide-3.392023-10-1810.1016/j.cell.2023.09.020
8HK5APeptideComplement PeptideC5a1Homo sapiensComplement C5-Gi1/β1/γ232023-05-1010.1038/s41589-023-01339-w
8HK5 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensComplement C5-32023-05-1010.1038/s41589-023-01339-w
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a anaphylatoxin-Go/β1/γ23.892023-10-1810.1016/j.cell.2023.09.020
8HQC (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a anaphylatoxin-3.892023-10-1810.1016/j.cell.2023.09.020
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-0110.1038/s41422-023-00779-2
7Y67 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC089 peptide-2.82023-03-0110.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-0110.1038/s41422-023-00779-2
7Y66 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensBM213-2.92023-03-0110.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a peptide-Gi1/β1/γ23.22023-03-0110.1038/s41422-023-00779-2
7Y65 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a peptide-3.22023-03-0110.1038/s41422-023-00779-2
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a anaphylatoxin-Gi1/β1/γ22.92023-03-0110.1038/s41422-023-00779-2
7Y64 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a anaphylatoxin-2.92023-03-0110.1038/s41422-023-00779-2
6C1RAPeptideComplement PeptideC5a1Homo sapiensPMX53Avacopan; Na-2.22018-05-3010.1038/s41594-018-0067-z
6C1QAPeptideComplement PeptideC5a1Homo sapiensPMX53NDT9513727-2.92018-05-3010.1038/s41594-018-0067-z
5O9HAPeptideComplement PeptideC5a1Homo sapiens-NDT9513727-2.72018-01-1010.1038/nature25025
5O9H (Multimeric) APeptideComplement PeptideC5a1Homo sapiens-NDT95137272.72018-01-1010.1038/nature25025




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Download 8HPT_nogp.zip



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