psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	8.54	No	No	0	0	0
2	L:L:K2	L:L:P3	5.02	No	No	0	0	0
3	L:L:?4	L:L:P3	4.63	Yes	No	0	0	0
4	L:L:P3	R:R:E280	6.29	No	No	0	0	3
5	L:L:?4	L:L:?5	25.53	Yes	Yes	0	0	0
6	L:L:?4	R:R:R175	5.71	Yes	Yes	0	0	4
7	L:L:?4	R:R:Y178	8.81	Yes	No	0	0	1
8	L:L:?5	L:L:?6	28.26	Yes	Yes	1	0	0
9	L:L:?5	R:R:L92	3.54	Yes	No	0	0	6
10	L:L:?5	R:R:I116	4.87	Yes	No	0	0	6
11	L:L:?5	R:R:L117	4.72	Yes	No	0	0	4
12	L:L:?5	R:R:Y259	4	Yes	Yes	1	0	7
13	L:L:?5	R:R:V287	6.36	Yes	No	0	0	5
14	L:L:?6	R:R:Y259	17.77	Yes	Yes	1	0	7
15	L:L:?6	R:R:T262	4.7	Yes	Yes	0	0	5
16	L:L:?6	R:R:G263	5.46	Yes	No	0	0	6
17	L:L:?6	R:R:N283	14.24	Yes	No	0	0	4
18	R:R:A40	R:R:S284	3.42	No	No	0	5	4
19	R:R:F93	R:R:L41	6.09	No	No	0	7	4
20	R:R:L41	R:R:V96	4.47	No	No	0	4	5
21	R:R:I43	R:R:S288	9.29	No	No	0	5	5
22	R:R:L89	R:R:Y44	9.38	Yes	Yes	0	8	8
23	R:R:S284	R:R:Y44	5.09	No	Yes	0	4	8
24	R:R:S288	R:R:Y44	6.36	No	Yes	0	5	8
25	R:R:C295	R:R:V47	3.42	No	No	0	8	8
26	R:R:F48	R:R:V52	7.87	Yes	No	0	7	6
27	R:R:F48	R:R:L89	6.09	Yes	Yes	4	7	8
28	R:R:F48	R:R:P90	7.22	Yes	No	4	7	8
29	R:R:C295	R:R:V50	3.42	No	No	0	8	6
30	R:R:G51	R:R:N55	5.09	No	Yes	0	8	9
31	R:R:C295	R:R:G51	3.92	No	No	0	8	8
32	R:R:P53	R:R:V52	5.3	No	No	0	4	6
33	R:R:D82	R:R:N55	16.16	Yes	Yes	5	9	9
34	R:R:N55	R:R:P298	6.52	Yes	No	5	9	9
35	R:R:F308	R:R:L57	3.65	Yes	No	0	8	6
36	R:R:L312	R:R:L57	4.15	No	No	0	6	6
37	R:R:V58	R:R:Y301	3.79	No	No	0	9	9
38	R:R:L76	R:R:T62	5.9	No	No	0	5	7
39	R:R:T62	R:R:Y301	3.75	No	No	0	7	9
40	R:R:A69	R:R:E65	4.53	No	No	0	7	5
41	R:R:A72	R:R:E65	6.03	No	No	0	7	5
42	R:R:E65	R:R:I73	15.03	No	No	0	5	6
43	R:R:R148	R:R:V70	6.54	Yes	No	0	7	6
44	R:R:A153	R:R:I73	3.25	No	No	0	8	6
45	R:R:I73	R:R:W154	12.92	No	No	0	6	4
46	R:R:T129	R:R:W74	3.64	No	Yes	0	7	7
47	R:R:I130	R:R:W74	3.52	No	Yes	0	9	7
48	R:R:D133	R:R:W74	13.4	No	Yes	0	8	7
49	R:R:A153	R:R:W74	5.19	No	Yes	0	8	7
50	R:R:F75	R:R:Y301	20.63	No	No	0	8	9
51	R:R:N77	R:R:W154	5.65	No	No	0	9	4
52	R:R:C157	R:R:N77	12.6	No	No	0	8	9
53	R:R:N77	R:R:W161	4.52	No	Yes	0	9	9
54	R:R:C86	R:R:D82	4.67	No	Yes	0	7	9
55	R:R:C294	R:R:D82	7.78	No	Yes	0	9	9
56	R:R:D82	R:R:P298	6.44	Yes	No	5	9	9
57	R:R:L83	R:R:L87	4.15	No	No	0	8	5
58	R:R:L84	R:R:N119	5.49	No	No	0	7	8
59	R:R:N119	R:R:S85	5.96	No	No	0	8	7
60	R:R:S85	R:R:Y291	5.09	No	Yes	0	7	7
61	R:R:C294	R:R:S85	3.44	No	No	0	9	7
62	R:R:A88	R:R:L112	4.73	No	Yes	0	7	5
63	R:R:L89	R:R:P90	3.28	Yes	No	4	8	8
64	R:R:L89	R:R:Y291	7.03	Yes	Yes	0	8	7
65	R:R:L112	R:R:V91	4.47	Yes	No	0	5	6
66	R:R:L92	R:R:Y291	3.52	No	Yes	0	6	7
67	R:R:F93	R:R:L97	7.31	No	No	0	7	3
68	R:R:Y101	R:R:Y103	11.91	No	No	0	5	3
69	R:R:F104	R:R:W102	12.03	No	No	0	8	9
70	R:R:C109	R:R:W102	13.06	No	No	0	9	9
71	R:R:D105	R:R:F104	3.58	Yes	No	0	7	8
72	R:R:D105	R:R:T107	7.23	Yes	No	0	7	3
73	R:R:A108	R:R:D105	4.63	No	Yes	0	7	7
74	R:R:C109	R:R:Y178	5.38	No	No	0	9	1
75	R:R:I110	R:R:R175	3.76	No	Yes	0	7	4
76	R:R:L112	R:R:P113	4.93	Yes	No	0	5	5
77	R:R:I116	R:R:L112	7.14	No	Yes	0	6	5
78	R:R:P113	R:R:R175	8.65	No	Yes	0	5	4
79	R:R:F172	R:R:S114	7.93	No	No	0	5	6
80	R:R:L115	R:R:N119	6.87	No	No	0	6	8
81	R:R:I116	R:R:Y291	3.63	No	Yes	0	6	7
82	R:R:L117	R:R:Y121	8.21	No	No	0	4	7
83	R:R:L118	R:R:T168	8.84	No	No	0	6	7
84	R:R:M120	R:R:W256	4.65	No	Yes	0	8	8
85	R:R:M120	R:R:Y291	5.99	No	Yes	0	8	7
86	R:R:R207	R:R:Y121	10.29	No	No	0	5	7
87	R:R:A122	R:R:W161	7.78	No	Yes	0	7	9
88	R:R:I124	R:R:P215	3.39	Yes	Yes	0	8	8
89	R:R:F252	R:R:I124	3.77	Yes	Yes	1	9	8
90	R:R:I124	R:R:W256	11.74	Yes	Yes	1	8	8
91	R:R:L125	R:R:L163	4.15	No	No	0	6	4
92	R:R:C157	R:R:L126	3.17	No	No	0	8	8
93	R:R:L127	R:R:N297	5.49	No	No	0	8	9
94	R:R:I130	R:R:R134	5.01	No	No	0	9	9
95	R:R:L219	R:R:S131	6.01	No	No	0	8	9
96	R:R:S131	R:R:Y223	12.72	No	Yes	0	9	9
97	R:R:D133	R:R:L137	4.07	No	No	3	8	8
98	R:R:D133	R:R:R148	10.72	No	Yes	3	8	7
99	R:R:R134	R:R:Y223	7.2	No	Yes	0	9	9
100	R:R:F135	R:R:F139	16.08	No	Yes	2	8	8
101	R:R:C222	R:R:F135	6.98	No	No	0	8	8
102	R:R:F135	R:R:F225	5.36	No	Yes	2	8	4
103	R:R:C144	R:R:L137	9.52	No	No	3	6	8
104	R:R:L137	R:R:R148	15.79	No	Yes	3	8	7
105	R:R:L226	R:R:V138	8.94	No	No	0	8	8
106	R:R:F139	R:R:F225	4.29	Yes	Yes	2	8	4
107	R:R:F139	R:R:R229	5.34	Yes	No	2	8	5
108	R:R:K140	R:R:W143	5.8	No	No	0	6	5
109	R:R:V147	R:R:W143	3.68	No	No	0	4	5
110	R:R:C144	R:R:R148	5.57	No	Yes	3	6	7
111	R:R:L167	R:R:V210	4.47	No	No	0	5	4
112	R:R:I169	R:R:P170	3.39	No	No	0	4	7
113	R:R:F172	R:R:I169	3.77	No	No	0	5	4
114	R:R:P170	R:R:V203	5.3	No	No	0	7	5
115	R:R:P170	R:R:R207	4.32	No	No	0	7	5
116	R:R:V173	R:R:Y174	3.79	No	No	0	4	4
117	R:R:I205	R:R:W268	8.22	No	No	0	4	4
118	R:R:L208	R:R:Q260	3.99	No	No	0	5	8
119	R:R:L208	R:R:V264	4.47	No	No	0	5	6
120	R:R:L214	R:R:V210	4.47	No	No	0	6	4
121	R:R:G211	R:R:P215	4.06	No	Yes	0	6	8
122	R:R:F212	R:R:F252	3.22	No	Yes	0	8	9
123	R:R:F212	R:R:Q260	10.54	No	No	0	8	8
124	R:R:F252	R:R:L216	3.65	Yes	No	0	9	6
125	R:R:F253	R:R:L216	4.87	No	No	0	6	6
126	R:R:F252	R:R:L219	4.87	Yes	No	0	9	8
127	R:R:N220	R:R:V249	4.43	No	No	0	4	8
128	R:R:V245	R:R:Y223	10.09	No	Yes	0	7	9
129	R:R:L227	R:R:L242	5.54	No	No	0	4	6
130	R:R:L227	R:R:V245	4.47	No	No	0	4	7
131	R:R:R237	R:R:W231	6	No	No	0	5	4
132	R:R:S238	R:R:T241	3.2	No	No	0	6	7
133	R:R:L242	R:R:M246	7.07	No	No	0	6	5
134	R:R:F252	R:R:W256	8.02	Yes	Yes	1	9	8
135	R:R:F255	R:R:I254	5.02	Yes	No	0	9	6
136	R:R:F255	R:R:L289	3.65	Yes	No	0	9	7
137	R:R:F255	R:R:I292	5.02	Yes	No	0	9	6
138	R:R:F255	R:R:N293	4.83	Yes	No	0	9	9
139	R:R:W256	R:R:Y259	6.75	Yes	Yes	1	8	7
140	R:R:A290	R:R:W256	5.19	No	Yes	0	8	8
141	R:R:N293	R:R:W256	13.56	No	Yes	0	9	8
142	R:R:L257	R:R:P258	3.28	No	No	0	6	9
143	R:R:C286	R:R:P258	3.77	No	No	0	7	9
144	R:R:L289	R:R:P258	3.28	No	No	0	7	9
145	R:R:Q260	R:R:Y259	3.38	No	Yes	0	8	7
146	R:R:T262	R:R:V279	3.17	Yes	No	0	5	4
147	R:R:C286	R:R:T262	6.76	No	Yes	0	7	5
148	R:R:I266	R:R:V279	4.61	No	No	0	4	4
149	R:R:L269	R:R:L276	9.69	No	No	0	1	1
150	R:R:P270	R:R:P271	5.84	No	No	0	3	1
151	R:R:P271	R:R:P274	7.79	No	No	0	1	1
152	R:R:L276	R:R:P274	13.14	No	No	0	1	1
153	R:R:L276	R:R:V279	4.47	No	No	0	1	4
154	R:R:E280	R:R:K277	4.05	No	No	0	3	2
155	R:R:N293	R:R:N297	8.17	No	No	0	9	9
156	R:R:F308	R:R:V302	10.49	Yes	No	0	8	7
157	R:R:R311	R:R:R314	9.6	No	No	0	5	5
158	R:R:A40	R:R:L285	3.15	No	No	0	5	6
159	R:R:A164	R:R:L118	3.15	No	No	0	7	6
160	R:R:A160	R:R:L126	3.15	No	No	0	7	8
161	R:R:I42	R:R:S45	3.1	No	No	0	5	5
162	R:R:I299	R:R:V296	3.07	No	No	0	7	7
163	R:R:M209	R:R:V210	3.04	No	No	0	6	4
164	R:R:K240	R:R:V244	3.04	No	No	0	7	8
165	R:R:K243	R:R:T239	3	No	No	0	5	5
166	R:R:N100	R:R:V96	2.96	No	No	0	3	5
167	R:R:L228	R:R:T224	2.95	No	No	0	1	3
168	R:R:L226	R:R:T230	2.95	No	No	0	8	8
169	R:R:I169	R:R:L165	2.85	No	No	0	4	4
170	R:R:I221	R:R:L217	2.85	No	No	0	5	3
171	R:R:C251	R:R:F255	2.79	No	Yes	0	7	9
172	R:R:L126	R:R:L78	2.77	No	No	0	8	9
173	R:R:L118	R:R:L165	2.77	No	No	0	6	4
174	R:R:L83	R:R:N55	2.75	No	Yes	0	8	9
175	R:R:R175	R:R:S171	2.64	Yes	No	0	4	5
176	R:R:F308	R:R:V58	2.62	Yes	No	0	8	9
177	R:R:F308	R:R:V61	2.62	Yes	No	0	8	7
178	R:R:R311	R:R:V61	2.62	No	No	0	5	7
179	R:R:F139	R:R:V138	2.62	Yes	No	2	8	8
180	R:R:R229	R:R:V138	2.62	No	No	2	5	8
181	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
182	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
183	R:R:V249	R:R:Y223	2.52	No	Yes	0	8	9
184	R:R:F225	R:R:I221	2.51	Yes	No	0	4	5
185	R:R:H309	R:R:Q306	2.47	No	No	0	7	5
186	R:R:V264	R:R:W268	2.45	No	No	0	6	4
187	R:R:T230	R:R:W231	2.43	No	No	0	8	4
188	R:R:T241	R:R:W231	2.43	No	No	0	7	4
189	L:L:?1	R:R:E176	2.29	No	No	0	0	3
190	R:R:L136	R:R:W143	2.28	No	No	0	6	5
191	R:R:F75	R:R:R134	2.14	No	No	0	8	9
192	R:R:G54	R:R:P53	2.03	No	No	0	8	4
193	R:R:A304	R:R:G305	1.95	No	No	0	7	8
194	R:R:A128	R:R:P215	1.87	No	Yes	0	7	8
195	R:R:G149	R:R:V70	1.84	No	No	0	6	6
196	R:R:G151	R:R:T150	1.82	No	No	0	4	1
197	R:R:A106	R:R:A177	1.79	No	No	0	2	4
198	R:R:A204	R:R:A267	1.79	No	No	0	5	5
199	R:R:P215	R:R:T218	1.75	Yes	No	0	8	7
200	R:R:G36	R:R:K281	1.74	No	No	0	4	3
201	R:R:C222	R:R:S131	1.72	No	No	0	8	9
202	R:R:C251	R:R:V296	1.71	No	No	0	7	7
203	R:R:A79	R:R:V58	1.7	No	No	0	9	9
204	R:R:A79	R:R:V59	1.7	No	No	0	9	7
205	R:R:A304	R:R:V244	1.7	No	No	0	7	8
206	R:R:I142	R:R:P141	1.69	No	No	0	5	8
207	R:R:K140	R:R:P141	1.67	No	No	0	6	8
208	R:R:L214	R:R:P215	1.64	No	Yes	0	6	8
209	R:R:S45	R:R:V46	1.62	No	No	0	5	6
210	R:R:V46	R:R:V47	1.6	No	No	0	6	8
211	R:R:V46	R:R:V50	1.6	No	No	0	6	6
212	R:R:V59	R:R:V80	1.6	No	No	0	7	6
213	R:R:V244	R:R:V245	1.6	No	No	0	8	7
214	R:R:V248	R:R:V249	1.6	No	No	0	8	8
215	R:R:T150	R:R:V70	1.59	No	No	0	1	6
216	R:R:T262	R:R:V261	1.59	Yes	No	0	5	6
217	R:R:G310	R:R:H309	1.59	No	No	0	5	7
218	R:R:A39	R:R:L285	1.58	No	No	0	5	6
219	R:R:A160	R:R:L125	1.58	No	No	0	7	6
220	R:R:T94	R:R:T95	1.57	No	No	0	5	5
221	R:R:A69	R:R:N71	1.56	No	No	0	7	8
222	R:R:I124	R:R:S123	1.55	Yes	No	0	8	9
223	R:R:A106	R:R:D105	1.54	No	Yes	0	2	7
224	R:R:K201	R:R:V203	1.52	No	No	0	4	5
225	R:R:M265	R:R:V261	1.52	No	No	0	5	6
226	R:R:L312	R:R:S315	1.5	No	No	0	6	6
227	R:R:L208	R:R:V213	1.49	No	No	0	5	5
228	R:R:N98	R:R:T94	1.46	No	No	0	4	5
229	R:R:K277	R:R:K281	1.44	No	No	0	2	3
230	R:R:G158	R:R:W161	1.41	No	Yes	0	4	9
231	L:L:?4	R:R:T95	1.39	Yes	No	0	0	5
232	R:R:A63	R:R:F64	1.39	No	No	0	4	5
233	R:R:L167	R:R:L206	1.38	No	No	0	5	3
234	R:R:L312	R:R:L313	1.38	No	No	0	6	4
235	R:R:D37	R:R:L285	1.36	No	No	0	4	6
236	R:R:R233	R:R:S232	1.32	No	No	0	4	4
237	R:R:R233	R:R:T236	1.29	No	No	0	4	3
238	R:R:F139	R:R:K140	1.24	Yes	No	0	8	6
239	R:R:K234	R:R:R237	1.24	No	No	0	4	5
240	R:R:F48	R:R:L49	1.22	Yes	No	0	7	6
241	R:R:F225	R:R:L228	1.22	Yes	No	0	4	1
242	R:R:N98	R:R:Y101	1.16	No	No	0	4	5
243	R:R:F308	R:R:H309	1.13	Yes	No	0	8	7
244	R:R:F93	R:R:Y44	1.03	No	Yes	0	7	8
245	R:R:F64	R:R:W60	1	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?4	9.214	5	0	0
2	L:L:?5	11.04	7	1	0
3	L:L:?6	14.086	5	1	0
4	R:R:Y44	5.465	4	0	8
5	R:R:F48	5.6	4	4	7
6	R:R:N55	7.63	4	5	9
7	R:R:W74	5.668	5	0	7
8	R:R:D82	8.7625	4	5	9
9	R:R:L89	6.445	4	4	8
10	R:R:D105	4.245	4	0	7
11	R:R:L112	5.3175	4	0	5
12	R:R:I124	5.1125	4	1	8
13	R:R:F139	5.914	5	2	8
14	R:R:R148	9.655	4	3	7
15	R:R:W161	4.075	4	0	9
16	R:R:R175	5.19	4	0	4
17	R:R:P215	2.542	5	0	8
18	R:R:Y223	8.1325	4	0	9
19	R:R:F225	3.345	4	2	4
20	R:R:F252	4.706	5	1	9
21	R:R:F255	4.262	5	0	9
22	R:R:W256	8.31833	6	1	8
23	R:R:Y259	7.975	4	1	7
24	R:R:T262	4.055	4	0	5
25	R:R:Y291	5.052	5	0	7
26	R:R:F308	4.102	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	L:L:P3	16.2802	4.63	Yes	No	0	0	0
2	L:L:?4	L:L:?5	50.1757	25.53	Yes	Yes	0	0	0
3	L:L:?4	R:R:Y178	18.8256	8.81	Yes	No	0	0	1
4	L:L:?5	L:L:?6	16.1006	28.26	Yes	Yes	1	0	0
5	L:L:?5	R:R:L92	22.3081	3.54	Yes	No	0	0	6
6	L:L:?5	R:R:I116	27.4069	4.87	Yes	No	0	0	6
7	L:L:?5	R:R:L117	25.978	4.72	Yes	No	0	0	4
8	L:L:?5	R:R:Y259	49.7697	4	Yes	Yes	1	0	7
9	L:L:?6	R:R:T262	23.3935	4.7	Yes	Yes	0	0	5
10	R:R:L92	R:R:Y291	22.2456	3.52	No	Yes	0	6	7
11	R:R:L89	R:R:Y291	44.0853	7.03	Yes	Yes	0	8	7
12	R:R:L89	R:R:Y44	29.3199	9.38	Yes	Yes	0	8	8
13	R:R:S284	R:R:Y44	11.3922	5.09	No	Yes	0	4	8
14	R:R:I116	R:R:Y291	28.1955	3.63	No	Yes	0	6	7
15	R:R:F93	R:R:Y44	11.7045	1.03	No	Yes	0	7	8
16	R:R:S85	R:R:Y291	46.5605	5.09	No	Yes	0	7	7
17	R:R:C294	R:R:S85	38.2213	3.44	No	No	0	9	7
18	R:R:C294	R:R:D82	36.0974	7.78	No	Yes	0	9	9
19	R:R:D82	R:R:N55	29.5307	16.16	Yes	Yes	5	9	9
20	R:R:G51	R:R:N55	23.0265	5.09	No	Yes	0	8	9
21	R:R:C295	R:R:G51	20.7933	3.92	No	No	0	8	8
22	R:R:F48	R:R:L89	11.6655	6.09	Yes	Yes	4	7	8
23	R:R:W256	R:R:Y259	58.1791	6.75	Yes	Yes	1	8	7
24	R:R:F252	R:R:W256	88.8889	8.02	Yes	Yes	1	9	8
25	R:R:F252	R:R:L219	100	4.87	Yes	No	0	9	8
26	R:R:L219	R:R:S131	99.7111	6.01	No	No	0	8	9
27	R:R:S131	R:R:Y223	84.1961	12.72	No	Yes	0	9	9
28	R:R:R134	R:R:Y223	73.1163	7.2	No	Yes	0	9	9
29	R:R:F75	R:R:R134	32.9742	2.14	No	No	0	8	9
30	R:R:F75	R:R:Y301	31.6624	20.63	No	No	0	8	9
31	R:R:V58	R:R:Y301	27.2039	3.79	No	No	0	9	9
32	R:R:F308	R:R:V58	20.7074	2.62	Yes	No	0	8	9
33	R:R:I130	R:R:R134	48.8171	5.01	No	No	0	9	9
34	R:R:I130	R:R:W74	47.474	3.52	No	Yes	0	9	7
35	R:R:A153	R:R:W74	30.6317	5.19	No	Yes	0	8	7
36	R:R:A153	R:R:I73	29.0622	3.25	No	No	0	8	6
37	R:R:D133	R:R:W74	15.6321	13.4	No	Yes	0	8	7
38	R:R:D133	R:R:R148	10.3849	10.72	No	Yes	3	8	7
39	R:R:I73	R:R:W154	20.9807	12.92	No	No	0	6	4
40	R:R:N77	R:R:W154	19.3176	5.65	No	No	0	9	4
41	R:R:C157	R:R:N77	10.7675	12.6	No	No	0	8	9
42	R:R:I116	R:R:L112	10.7675	7.14	No	Yes	0	6	5
43	L:L:?4	R:R:T95	10.6114	1.39	Yes	No	0	0	5
44	R:R:C109	R:R:Y178	16.7955	5.38	No	No	0	9	1
45	R:R:C109	R:R:W102	14.7497	13.06	No	No	0	9	9
46	R:R:F104	R:R:W102	12.6884	12.03	No	No	0	8	9
47	R:R:D105	R:R:F104	10.6114	3.58	Yes	No	0	7	8
48	R:R:L117	R:R:Y121	24.1509	8.21	No	No	0	4	7
49	R:R:R207	R:R:Y121	22.1754	10.29	No	No	0	5	7
50	R:R:P170	R:R:R207	20.4263	4.32	No	No	0	7	5
51	R:R:I169	R:R:P170	14.6404	3.39	No	No	0	4	7
52	R:R:M120	R:R:Y291	46.9431	5.99	No	Yes	0	8	7
53	R:R:M120	R:R:W256	47.3101	4.65	No	Yes	0	8	8
54	R:R:I124	R:R:W256	11.3297	11.74	Yes	Yes	1	8	8
55	R:R:I124	R:R:P215	16.366	3.39	Yes	Yes	0	8	8
56	R:R:N293	R:R:W256	19.1614	13.56	No	Yes	0	9	8
57	R:R:C222	R:R:S131	37.7528	1.72	No	No	0	8	9
58	R:R:C222	R:R:F135	36.2614	6.98	No	No	0	8	8
59	R:R:F135	R:R:F139	26.3606	16.08	No	Yes	2	8	8
60	R:R:F139	R:R:V138	13.9221	2.62	Yes	No	2	8	8
61	R:R:L226	R:R:V138	12.2433	8.94	No	No	0	8	8
62	R:R:F139	R:R:K140	10.7675	1.24	Yes	No	0	8	6
63	R:R:Q260	R:R:Y259	10.5723	3.38	No	Yes	0	8	7
64	R:R:L208	R:R:Q260	12.4854	3.99	No	No	0	5	8
65	R:R:V245	R:R:Y223	13.7113	10.09	No	Yes	0	7	9
66	R:R:L226	R:R:T230	10.5177	2.95	No	No	0	8	8
67	R:R:F255	R:R:N293	14.1719	4.83	Yes	No	0	9	9
68	R:R:T262	R:R:V279	13.7581	3.17	Yes	No	0	5	4
69	R:R:L276	R:R:V279	10.1663	4.47	No	No	0	1	4
70	L:L:?6	R:R:Y259	12.54	17.77	Yes	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P3	R:R:E280	6.29	0	No	No	0	3	0	1
L:L:?4	R:R:R175	5.71	0	Yes	Yes	0	4	0	1
L:L:?4	R:R:Y178	8.81	0	Yes	No	0	1	0	1
L:L:?5	R:R:L92	3.54	1	Yes	No	0	6	0	1
L:L:?5	R:R:I116	4.87	1	Yes	No	0	6	0	1
L:L:?5	R:R:L117	4.72	1	Yes	No	0	4	0	1
L:L:?5	R:R:Y259	4	1	Yes	Yes	0	7	0	1
L:L:?5	R:R:V287	6.36	1	Yes	No	0	5	0	1
L:L:?6	R:R:Y259	17.77	1	Yes	Yes	0	7	0	1
L:L:?6	R:R:T262	4.7	1	Yes	Yes	0	5	0	1
L:L:?6	R:R:G263	5.46	1	Yes	No	0	6	0	1
L:L:?6	R:R:N283	14.24	1	Yes	No	0	4	0	1
R:R:L92	R:R:Y291	3.52	0	No	Yes	6	7	1	2
R:R:C109	R:R:Y178	5.38	0	No	No	9	1	2	1
R:R:I110	R:R:R175	3.76	0	No	Yes	7	4	2	1
R:R:L112	R:R:P113	4.93	0	Yes	No	5	5	2	2
R:R:I116	R:R:L112	7.14	0	No	Yes	6	5	1	2
R:R:P113	R:R:R175	8.65	0	No	Yes	5	4	2	1
R:R:I116	R:R:Y291	3.63	0	No	Yes	6	7	1	2
R:R:L117	R:R:Y121	8.21	0	No	No	4	7	1	2
R:R:W256	R:R:Y259	6.75	1	Yes	Yes	8	7	2	1
R:R:Q260	R:R:Y259	3.38	0	No	Yes	8	7	2	1
R:R:T262	R:R:V279	3.17	0	Yes	No	5	4	1	2
R:R:C286	R:R:T262	6.76	0	No	Yes	7	5	2	1
R:R:E280	R:R:K277	4.05	0	No	No	3	2	1	2
R:R:R175	R:R:S171	2.64	0	Yes	No	4	5	1	2
L:L:?1	R:R:E176	2.29	0	No	No	0	3	0	1
R:R:T262	R:R:V261	1.59	0	Yes	No	5	6	1	2
R:R:T94	R:R:T95	1.57	0	No	No	5	5	2	1
L:L:?4	R:R:T95	1.39	0	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HPT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	237
Number of Links	245
Number of Hubs	26
Number of Links mediated by Hubs	102
Number of Communities	5
Number of Nodes involved in Communities	21
Number of Links involved in Communities	24

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	29563
Length Of Smallest Path	3
Average Path Length	12.2834
Length of Longest Path	29
Minimum Path Strength	1.195
Average Path Strength	6.61323
Maximum Path Strength	20.8667
Minimum Path Correlation	0.7
Average Path Correlation	0.923843
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	49.4393
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.4206
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951134
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ZAL
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	ZAL
Name	3-cyclohexyl-D-alanine
Synonyms
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	25322977
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	ALC
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	ALC
Name	3-Cyclohexyl-L-alanine
Synonyms	beta-Cyclohexyl-alanine β-Cyclohexyl-alanine 3-Cyclohexyl-L-alanine beta-Cyclohexyl-L-alanine
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	712421
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	DAR
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DAR
Name	D-arginine
Synonyms	(2R)-2-amino-5-guanidinopentanoic acid
Identifier
Formula	C6 H15 N4 O2
Molecular Weight	175.209
SMILES
PubChem	58433835
Formal Charge	1
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30993
Sequence	>8HPT_nogp_Chain_R G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H N Y W Y F D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q K V R G T G L A W M A C G V A W V L A L L L T I P S F V Y R E A Y K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R K A T R S T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L P P S S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F H G R L L R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HPT_nogp.zip

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