psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D37	R:R:L33	4.07	No	No	0	4	4
2	R:R:H99	R:R:L33	2.57	No	No	0	2	4
3	R:R:K280	R:R:R34	18.56	No	No	0	2	2
4	R:R:P36	R:R:V35	3.53	Yes	No	0	3	3
5	R:R:D37	R:R:S283	2.94	No	No	0	4	4
6	R:R:A40	R:R:S283	3.42	No	No	0	6	4
7	R:R:A40	R:R:S287	3.42	No	No	0	6	4
8	R:R:F93	R:R:L41	4.87	No	No	0	7	5
9	R:R:I43	R:R:S287	7.74	No	No	0	5	4
10	R:R:F44	R:R:L89	15.83	No	No	0	7	7
11	R:R:F44	R:R:V286	2.62	No	Yes	0	7	5
12	R:R:F44	R:R:Y290	6.19	No	Yes	0	7	7
13	R:R:V47	R:R:Y290	2.52	No	Yes	0	6	7
14	R:R:C294	R:R:V47	3.42	Yes	No	0	7	6
15	R:R:F48	R:R:L49	3.65	Yes	No	0	6	4
16	R:R:F48	R:R:V52	3.93	Yes	No	0	6	5
17	R:R:F48	R:R:L89	6.09	Yes	No	0	6	7
18	R:R:F48	R:R:P90	7.22	Yes	No	0	6	9
19	R:R:C294	R:R:V50	3.42	Yes	No	0	7	6
20	R:R:F83	R:R:V52	3.93	No	No	0	8	5
21	R:R:D82	R:R:N55	13.46	No	No	0	9	9
22	R:R:F83	R:R:N55	6.04	No	No	0	8	9
23	R:R:N55	R:R:P297	4.89	No	No	0	9	9
24	R:R:L57	R:R:V61	2.98	No	No	0	5	6
25	R:R:F307	R:R:L57	3.65	Yes	No	2	9	5
26	R:R:L311	R:R:L57	5.54	No	No	2	6	5
27	R:R:S314	R:R:W60	6.18	No	No	0	4	4
28	R:R:R310	R:R:V61	3.92	Yes	No	0	4	6
29	R:R:L76	R:R:T62	5.9	No	No	0	6	6
30	R:R:E65	R:R:F64	8.16	No	No	0	5	4
31	R:R:F64	R:R:S314	11.89	No	No	0	4	4
32	R:R:E65	R:R:R310	8.14	No	Yes	0	5	4
33	R:R:E65	R:R:K313	4.05	No	No	0	5	4
34	R:R:A72	R:R:T69	3.36	No	No	0	7	7
35	R:R:I70	R:R:R148	11.27	No	No	0	6	7
36	R:R:A153	R:R:I73	3.25	No	Yes	0	7	6
37	R:R:I73	R:R:W154	10.57	Yes	No	0	6	3
38	R:R:T129	R:R:W74	3.64	No	Yes	0	6	7
39	R:R:I130	R:R:W74	5.87	No	Yes	0	8	7
40	R:R:D133	R:R:W74	10.05	No	Yes	0	8	7
41	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
42	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
43	R:R:C157	R:R:W74	3.92	No	Yes	0	6	7
44	R:R:F75	R:R:I130	5.02	No	No	0	8	8
45	R:R:F75	R:R:Y300	12.38	No	No	0	8	9
46	R:R:N77	R:R:W154	3.39	No	No	0	9	3
47	R:R:C157	R:R:N77	4.72	No	No	0	6	9
48	R:R:N77	R:R:W161	4.52	No	No	0	9	9
49	R:R:L126	R:R:L78	4.15	No	No	0	7	9
50	R:R:L127	R:R:L78	4.15	No	No	0	8	9
51	R:R:A81	R:R:W161	2.59	No	No	0	8	9
52	R:R:C293	R:R:D82	6.22	No	No	0	8	9
53	R:R:F83	R:R:L87	4.87	No	No	0	8	4
54	R:R:L84	R:R:N119	5.49	No	No	0	6	9
55	R:R:N119	R:R:S85	5.96	No	No	0	9	6
56	R:R:S85	R:R:Y290	5.09	No	Yes	0	6	7
57	R:R:F104	R:R:I91	3.77	Yes	No	0	7	6
58	R:R:I91	R:R:L112	5.71	No	No	0	6	5
59	R:R:T94	R:R:V97	3.17	No	No	0	3	3
60	R:R:Q98	R:R:T94	4.25	No	No	0	4	3
61	R:R:F104	R:R:T94	2.59	Yes	No	0	7	3
62	R:R:S95	R:R:W102	6.18	No	Yes	0	4	8
63	L:L:?4	R:R:I96	2.68	Yes	No	0	0	5
64	R:R:H101	R:R:Q98	7.42	No	No	3	4	4
65	R:R:P103	R:R:Q98	4.74	No	No	3	3	4
66	L:L:?4	R:R:H100	14.5	Yes	No	0	0	4
67	R:R:H101	R:R:P103	10.68	No	No	3	4	3
68	R:R:F104	R:R:W102	21.05	Yes	Yes	0	7	8
69	R:R:C109	R:R:W102	9.14	Yes	Yes	4	9	8
70	R:R:C188	R:R:W102	6.53	No	Yes	4	9	8
71	R:R:F104	R:R:P103	4.33	Yes	No	0	7	3
72	R:R:G106	R:R:V177	3.68	No	No	0	3	4
73	R:R:C109	R:R:P113	3.77	Yes	No	0	9	6
74	R:R:C109	R:R:R175	2.79	Yes	Yes	0	9	5
75	R:R:C109	R:R:C188	7.28	Yes	No	4	9	9
76	R:R:L112	R:R:P113	3.28	No	No	0	5	6
77	R:R:S114	R:R:S171	6.52	No	No	0	5	5
78	R:R:F172	R:R:S114	5.28	No	No	0	4	5
79	R:R:R175	R:R:S114	3.95	Yes	No	0	5	5
80	R:R:L117	R:R:Y121	4.69	No	No	5	4	7
81	R:R:L117	R:R:S171	3	No	No	0	4	5
82	R:R:L117	R:R:R206	3.64	No	No	5	4	6
83	R:R:L118	R:R:N119	4.12	Yes	No	0	5	9
84	R:R:A164	R:R:L118	3.15	No	Yes	0	7	5
85	R:R:L118	R:R:L165	4.15	Yes	No	0	5	4
86	R:R:L118	R:R:T168	10.32	Yes	No	0	5	6
87	R:R:M120	R:R:W255	5.82	No	Yes	0	7	9
88	R:R:L167	R:R:Y121	4.69	No	No	0	4	7
89	R:R:R206	R:R:Y121	12.35	No	No	5	6	7
90	R:R:A122	R:R:W161	5.19	No	No	0	6	9
91	R:R:I124	R:R:P214	3.39	Yes	Yes	0	8	9
92	R:R:F251	R:R:I124	3.77	Yes	Yes	6	9	8
93	R:R:I124	R:R:W255	4.7	Yes	Yes	6	8	9
94	R:R:L125	R:R:L163	5.54	No	No	0	6	4
95	R:R:I130	R:R:R134	5.01	No	No	0	8	9
96	R:R:L218	R:R:S131	3	No	No	0	8	9
97	R:R:C221	R:R:S131	3.44	No	No	0	6	9
98	R:R:S131	R:R:Y222	8.9	No	Yes	0	9	8
99	R:R:D133	R:R:L137	2.71	No	No	0	8	8
100	R:R:R134	R:R:Y222	4.12	No	Yes	0	9	8
101	R:R:F135	R:R:F139	10.72	No	No	0	8	7
102	R:R:C221	R:R:F135	6.98	No	No	0	6	8
103	R:R:F135	R:R:F224	4.29	No	No	0	8	3
104	R:R:C144	R:R:L137	3.17	No	No	0	5	8
105	R:R:L137	R:R:R148	9.72	No	No	0	8	7
106	R:R:F139	R:R:V138	3.93	No	No	7	7	8
107	R:R:I225	R:R:V138	7.68	No	No	0	8	8
108	R:R:R228	R:R:V138	2.62	No	No	7	5	8
109	R:R:F139	R:R:R228	21.38	No	No	7	7	5
110	R:R:C144	R:R:W143	2.61	No	No	0	5	5
111	R:R:F147	R:R:W143	7.02	No	No	0	4	5
112	R:R:N146	R:R:Q145	2.64	No	No	0	5	5
113	R:R:F147	R:R:N146	3.62	No	No	0	4	5
114	R:R:F172	R:R:T168	5.19	No	No	0	4	6
115	R:R:I169	R:R:P170	3.39	No	No	0	3	8
116	R:R:F172	R:R:I169	2.51	No	No	0	4	3
117	R:R:I169	R:R:L173	2.85	No	No	0	3	4
118	R:R:P170	R:R:V202	3.53	No	No	0	8	5
119	R:R:L173	R:R:Y174	4.69	No	No	0	4	4
120	R:R:Y174	R:R:Y192	7.94	No	No	0	4	5
121	R:R:D195	R:R:Y174	3.45	No	No	0	3	4
122	R:R:G189	R:R:R175	4.5	No	Yes	0	4	5
123	R:R:R175	R:R:V190	2.62	Yes	No	0	5	5
124	R:R:D191	R:R:V176	4.38	No	No	0	4	4
125	R:R:C188	R:R:V177	5.12	No	No	0	9	4
126	L:L:?1	R:R:R178	5.26	Yes	No	0	0	2
127	R:R:E179	R:R:V186	5.7	No	No	0	2	6
128	L:L:?1	R:R:L187	5.99	Yes	No	0	0	4
129	L:L:?1	R:R:G189	2.96	Yes	No	0	0	4
130	R:R:V190	R:R:Y192	3.79	No	No	0	5	5
131	R:R:D191	R:R:S193	2.94	No	No	0	4	4
132	L:L:?1	R:R:D191	3.52	Yes	No	0	0	4
133	R:R:E199	R:R:Y192	16.83	No	No	0	4	5
134	R:R:D195	R:R:R198	7.15	No	No	0	3	3
135	L:L:K2	R:R:E199	5.4	Yes	No	0	0	4
136	R:R:F267	R:R:R200	5.34	No	No	0	4	3
137	R:R:A203	R:R:S266	3.42	No	No	0	5	5
138	R:R:F267	R:R:I204	3.77	No	No	0	4	3
139	R:R:L207	R:R:Q259	6.65	No	No	0	5	8
140	R:R:I263	R:R:L207	5.71	No	No	0	5	5
141	R:R:G210	R:R:L209	3.42	No	No	0	6	4
142	R:R:F211	R:R:L212	2.44	Yes	No	0	8	4
143	R:R:F211	R:R:L215	2.44	Yes	No	0	8	5
144	R:R:F211	R:R:L256	2.44	Yes	No	0	8	5
145	R:R:F211	R:R:Q259	7.03	Yes	No	0	8	8
146	R:R:P214	R:R:W213	6.76	Yes	No	0	9	5
147	R:R:T217	R:R:W213	4.85	No	No	0	5	5
148	R:R:F251	R:R:L215	3.65	Yes	No	0	9	5
149	R:R:F252	R:R:L215	3.65	No	No	0	5	5
150	R:R:L216	R:R:T219	2.95	No	No	0	2	4
151	R:R:F251	R:R:L218	2.44	Yes	No	0	9	8
152	R:R:F224	R:R:I220	3.77	No	No	0	3	3
153	R:R:V244	R:R:Y222	15.14	No	Yes	0	7	8
154	R:R:V248	R:R:Y222	2.52	No	Yes	0	7	8
155	R:R:L226	R:R:W230	4.56	No	No	0	5	4
156	R:R:L226	R:R:L241	4.15	No	No	0	5	6
157	R:R:R236	R:R:W230	3	No	No	0	5	4
158	R:R:R233	R:R:R236	4.26	No	No	0	4	5
159	R:R:K239	R:R:V243	3.04	No	No	0	7	7
160	R:R:A303	R:R:K239	3.21	No	No	0	6	7
161	R:R:L241	R:R:V245	2.98	No	No	0	6	4
162	R:R:F251	R:R:W255	6.01	Yes	Yes	6	9	9
163	R:R:F252	R:R:L256	4.87	No	No	0	5	5
164	R:R:F254	R:R:F288	5.36	Yes	No	0	8	8
165	R:R:F254	R:R:I291	15.07	Yes	No	0	8	5
166	R:R:W255	R:R:Y258	7.72	Yes	No	0	9	7
167	R:R:A289	R:R:W255	5.19	No	Yes	0	8	9
168	R:R:N292	R:R:W255	7.91	No	Yes	0	9	9
169	R:R:L256	R:R:P257	3.28	No	No	0	5	9
170	R:R:Q259	R:R:Y258	5.64	No	No	0	8	7
171	L:L:?6	R:R:Y258	14.03	Yes	No	0	0	7
172	R:R:G262	R:R:T261	3.64	No	Yes	1	5	4
173	R:R:C285	R:R:T261	8.45	No	Yes	0	6	4
174	L:L:?6	R:R:T261	3.53	Yes	Yes	1	0	4
175	L:L:?6	R:R:G262	4.09	Yes	No	1	0	5
176	R:R:F267	R:R:I263	8.79	No	No	0	4	5
177	R:R:L278	R:R:M265	5.65	No	No	0	4	4
178	R:R:D282	R:R:M265	6.93	Yes	No	0	4	4
179	R:R:L268	R:R:S272	3	No	No	0	2	4
180	R:R:L268	R:R:T274	5.9	No	No	0	2	1
181	R:R:E269	R:R:P270	9.43	No	No	0	3	3
182	R:R:E269	R:R:S271	5.75	No	No	0	3	4
183	R:R:F275	R:R:P270	4.33	Yes	No	0	3	3
184	R:R:F275	R:R:K279	7.44	Yes	No	8	3	4
185	L:L:K2	R:R:F275	2.48	Yes	Yes	8	0	3
186	L:L:K2	R:R:K279	2.87	Yes	No	8	0	4
187	L:L:P3	R:R:K279	3.35	No	No	0	0	4
188	R:R:D282	R:R:V286	4.38	Yes	Yes	1	4	5
189	L:L:W5	R:R:D282	5.58	Yes	Yes	1	0	4
190	L:L:?6	R:R:D282	8.66	Yes	Yes	1	0	4
191	L:L:W5	R:R:V286	22.07	Yes	Yes	1	0	5
192	L:L:?6	R:R:V286	5.94	Yes	Yes	1	0	5
193	R:R:C294	R:R:I291	3.27	Yes	No	0	7	5
194	R:R:N292	R:R:N296	8.17	No	No	0	9	9
195	R:R:I295	R:R:I299	2.94	No	No	0	7	7
196	R:R:R310	R:R:Y300	6.17	Yes	No	0	4	9
197	R:R:F307	R:R:V301	7.87	Yes	No	0	9	6
198	R:R:F307	R:R:R310	3.21	Yes	Yes	0	9	4
199	R:R:F307	R:R:L311	3.65	Yes	No	2	9	6
200	R:R:Q308	R:R:R312	3.5	No	No	0	8	5
201	L:L:?1	L:L:K2	9.76	Yes	Yes	0	0	0
202	L:L:?1	L:L:P3	4.26	Yes	No	0	0	0
203	L:L:?4	L:L:W5	4.28	Yes	Yes	0	0	0
204	L:L:?6	L:L:W5	9.09	Yes	Yes	1	0	0
205	R:R:L311	R:R:R312	2.43	No	No	0	6	5
206	R:R:F75	R:R:N71	2.42	No	No	0	8	7
207	R:R:L136	R:R:W143	2.28	No	No	0	5	5
208	R:R:G105	R:R:G106	2.11	No	No	0	7	3
209	R:R:G210	R:R:P214	2.03	No	Yes	0	6	9
210	R:R:C86	R:R:G51	1.96	No	No	0	5	8
211	R:R:A128	R:R:P214	1.87	No	Yes	0	7	9
212	R:R:P273	R:R:S272	1.78	No	No	0	2	4
213	R:R:P297	R:R:V58	1.77	No	No	0	9	8
214	R:R:C86	R:R:V52	1.71	No	No	0	5	5
215	R:R:G54	R:R:L53	1.71	No	No	0	7	4
216	R:R:G162	R:R:L165	1.71	No	No	0	4	4
217	R:R:A79	R:R:V58	1.7	No	No	0	8	8
218	R:R:A79	R:R:V59	1.7	No	No	0	8	7
219	R:R:A72	R:R:T62	1.68	No	No	0	7	6
220	R:R:A160	R:R:T129	1.68	No	No	0	6	6
221	R:R:K140	R:R:P141	1.67	No	No	0	6	8
222	R:R:L284	R:R:P36	1.64	No	Yes	0	4	3
223	R:R:C294	R:R:I298	1.64	Yes	No	0	7	7
224	R:R:A66	R:R:I73	1.62	No	Yes	0	5	6
225	R:R:A150	R:R:I73	1.62	No	Yes	0	3	6
226	R:R:A203	R:R:I263	1.62	No	No	0	5	5
227	R:R:A249	R:R:I253	1.62	No	No	0	4	5
228	R:R:A303	R:R:I299	1.62	No	No	0	6	7
229	R:R:D37	R:R:P36	1.61	No	Yes	0	4	3
230	R:R:V59	R:R:V80	1.6	No	No	0	7	5
231	R:R:V177	R:R:V186	1.6	No	No	0	4	6
232	R:R:V243	R:R:V247	1.6	No	No	0	7	7
233	R:R:T219	R:R:V248	1.59	No	No	0	4	7
234	R:R:T240	R:R:V244	1.59	No	No	0	7	7
235	R:R:T261	R:R:V260	1.59	Yes	No	0	4	6
236	R:R:C285	R:R:L281	1.59	No	No	0	6	5
237	R:R:A63	R:R:L76	1.58	No	No	0	3	6
238	R:R:A66	R:R:L76	1.58	No	No	0	5	6
239	R:R:A160	R:R:L125	1.58	No	No	0	6	6
240	R:R:A160	R:R:L126	1.58	No	No	0	6	7
241	R:R:T229	R:R:T235	1.57	No	No	0	8	4
242	R:R:I124	R:R:S123	1.55	Yes	No	0	8	9
243	R:R:I38	R:R:V42	1.54	No	No	0	5	5
244	R:R:I298	R:R:V302	1.54	No	No	0	7	6
245	R:R:K239	R:R:S237	1.53	No	No	0	7	7
246	R:R:I225	R:R:T229	1.52	No	No	0	8	8
247	R:R:M264	R:R:V260	1.52	No	No	0	4	6
248	R:R:G149	R:R:R148	1.5	No	No	0	5	7
249	R:R:G304	R:R:R310	1.5	No	Yes	0	8	4
250	R:R:L212	R:R:V208	1.49	No	No	0	4	4
251	R:R:I291	R:R:I295	1.47	No	No	0	5	7
252	R:R:I295	R:R:I298	1.47	No	No	0	7	7
253	R:R:P36	R:R:R34	1.44	Yes	No	0	3	2
254	R:R:I38	R:R:L33	1.43	No	No	0	5	4
255	R:R:I38	R:R:L39	1.43	No	No	0	5	5
256	R:R:G151	R:R:W154	1.41	No	No	0	4	3
257	R:R:A108	R:R:F104	1.39	No	Yes	0	5	7
258	R:R:H194	R:R:S193	1.39	No	No	0	1	4
259	R:R:L277	R:R:L281	1.38	No	No	0	1	5
260	R:R:E269	R:R:K196	1.35	No	No	0	3	2
261	R:R:A116	R:R:Y290	1.33	No	Yes	0	6	7
262	R:R:F254	R:R:S250	1.32	Yes	No	0	8	6
263	R:R:F275	R:R:S272	1.32	Yes	No	0	3	4
264	L:L:?4	R:R:L92	1.3	Yes	No	0	0	6
265	R:R:R68	R:R:T69	1.29	No	No	0	7	7
266	R:R:R232	R:R:T235	1.29	No	No	0	5	4
267	R:R:F252	R:R:I253	1.26	No	No	0	5	5
268	R:R:F254	R:R:I253	1.26	Yes	No	0	8	5
269	R:R:T229	R:R:W230	1.21	No	No	0	8	4
270	R:R:R197	R:R:R198	1.07	No	No	0	1	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P36	2.055	4	0	3
2	R:R:F48	5.2225	4	0	6
3	R:R:I73	4.265	4	0	6
4	R:R:W74	5.21	6	0	7
5	R:R:W102	10.725	4	4	8
6	R:R:F104	6.626	5	0	7
7	R:R:C109	5.745	4	4	9
8	R:R:L118	5.435	4	0	5
9	R:R:I124	3.3525	4	6	8
10	R:R:R175	3.465	4	0	5
11	R:R:F211	3.5875	4	0	8
12	R:R:P214	3.5125	4	0	9
13	R:R:Y222	7.67	4	0	8
14	R:R:F251	3.9675	4	6	9
15	R:R:F254	5.7525	4	0	8
16	R:R:W255	6.225	6	6	9
17	R:R:T261	4.3025	4	1	4
18	R:R:F275	3.8925	4	8	3
19	R:R:D282	6.3875	4	1	4
20	R:R:V286	8.7525	4	1	5
21	R:R:Y290	3.7825	4	0	7
22	R:R:C294	2.9375	4	0	7
23	R:R:F307	4.595	4	2	9
24	R:R:R310	4.588	5	0	4
25	L:L:?1	5.29167	6	0	0
26	L:L:K2	5.1275	4	8	0
27	L:L:?4	5.69	4	0	0
28	L:L:W5	10.255	4	1	0
29	L:L:?6	7.55667	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F44	R:R:Y290	84.0375	6.19	No	Yes	0	7	7
2	R:R:V47	R:R:Y290	22.3604	2.52	No	Yes	0	6	7
3	R:R:C294	R:R:V47	21.6527	3.42	Yes	No	0	7	6
4	R:R:F44	R:R:L89	28.4295	15.83	No	No	0	7	7
5	R:R:F48	R:R:L89	26.8711	6.09	Yes	No	0	6	7
6	R:R:F48	R:R:V52	22.1102	3.93	Yes	No	0	6	5
7	R:R:F83	R:R:V52	17.2207	3.93	No	No	0	8	5
8	R:R:F83	R:R:N55	13.8895	6.04	No	No	0	8	9
9	R:R:F44	R:R:V286	88.541	2.62	No	Yes	0	7	5
10	L:L:?6	R:R:V286	82.5077	5.94	Yes	Yes	1	0	5
11	L:L:?6	R:R:Y258	90.0994	14.03	Yes	No	0	0	7
12	R:R:W255	R:R:Y258	83.3298	7.72	Yes	No	0	9	7
13	R:R:F251	R:R:W255	76.0812	6.01	Yes	Yes	6	9	9
14	R:R:F251	R:R:L218	100	2.44	Yes	No	0	9	8
15	R:R:L218	R:R:S131	99.471	3	No	No	0	8	9
16	R:R:S131	R:R:Y222	85.989	8.9	No	Yes	0	9	8
17	R:R:R134	R:R:Y222	80.3846	4.12	No	Yes	0	9	8
18	R:R:I130	R:R:R134	79.4839	5.01	No	No	0	8	9
19	R:R:F75	R:R:I130	29.2301	5.02	No	No	0	8	8
20	R:R:F75	R:R:Y300	26.2278	12.38	No	No	0	8	9
21	R:R:R310	R:R:Y300	24.7909	6.17	Yes	No	0	4	9
22	R:R:F307	R:R:R310	10.3367	3.21	Yes	Yes	0	9	4
23	R:R:I130	R:R:W74	59.1107	5.87	No	Yes	0	8	7
24	R:R:A153	R:R:W74	20.1658	5.19	No	Yes	0	7	7
25	R:R:A153	R:R:I73	18.5574	3.25	No	Yes	0	7	6
26	R:R:A66	R:R:I73	12.2525	1.62	No	Yes	0	5	6
27	R:R:A66	R:R:L76	10.544	1.58	No	No	0	5	6
28	R:R:D133	R:R:W74	18.7933	10.05	No	Yes	0	8	7
29	R:R:D133	R:R:L137	17.1563	2.71	No	No	0	8	8
30	R:R:C157	R:R:W74	11.8021	3.92	No	Yes	0	6	7
31	R:R:C157	R:R:N77	10.1651	4.72	No	No	0	6	9
32	R:R:T129	R:R:W74	12.2739	3.64	No	Yes	0	6	7
33	R:R:A160	R:R:T129	10.5869	1.68	No	No	0	6	6
34	R:R:S85	R:R:Y290	90.1494	5.09	No	Yes	0	6	7
35	R:R:N119	R:R:S85	89.3631	5.96	No	No	0	9	6
36	R:R:F104	R:R:W102	15.3764	21.05	Yes	Yes	0	7	8
37	R:R:C109	R:R:W102	18.1643	9.14	Yes	Yes	4	9	8
38	R:R:C109	R:R:R175	34.1554	2.79	Yes	Yes	0	9	5
39	R:R:R175	R:R:S114	64.2362	3.95	Yes	No	0	5	5
40	R:R:F172	R:R:S114	70.5769	5.28	No	No	0	4	5
41	R:R:F172	R:R:T168	83.4584	5.19	No	No	0	4	6
42	R:R:L118	R:R:T168	84.3448	10.32	Yes	No	0	5	6
43	R:R:L118	R:R:N119	87.7475	4.12	Yes	No	0	5	9
44	R:R:I124	R:R:P214	10.2009	3.39	Yes	Yes	0	8	9
45	R:R:C221	R:R:S131	28.3008	3.44	No	No	0	6	9
46	R:R:C221	R:R:F135	26.7281	6.98	No	No	0	6	8
47	R:R:F135	R:R:F139	21.9172	10.72	No	No	0	8	7
48	R:R:C144	R:R:L137	10.5869	3.17	No	No	0	5	8
49	R:R:F139	R:R:V138	18.7576	3.93	No	No	7	7	8
50	R:R:I225	R:R:V138	17.1635	7.68	No	No	0	8	8
51	R:R:F172	R:R:I169	14.4471	2.51	No	No	0	4	3
52	R:R:I169	R:R:L173	10.0579	2.85	No	No	0	3	4
53	R:R:G189	R:R:R175	32.1467	4.5	No	Yes	0	4	5
54	L:L:?1	R:R:G189	30.667	2.96	Yes	No	0	0	4
55	L:L:?1	L:L:K2	17.5495	9.76	Yes	Yes	0	0	0
56	R:R:I263	R:R:L207	14.7902	5.71	No	No	0	5	5
57	R:R:L207	R:R:Q259	17.2064	6.65	No	No	0	5	8
58	R:R:Q259	R:R:Y258	18.5217	5.64	No	No	0	8	7
59	R:R:F211	R:R:Q259	13.7966	7.03	Yes	No	0	8	8
60	R:R:F251	R:R:L215	26.4422	3.65	Yes	No	0	9	5
61	R:R:F211	R:R:L215	11.4947	2.44	Yes	No	0	8	5
62	R:R:F252	R:R:L215	19.7369	3.65	No	No	0	5	5
63	R:R:F252	R:R:I253	21.1666	1.26	No	No	0	5	5
64	R:R:F254	R:R:I253	20.1944	1.26	Yes	No	0	8	5
65	R:R:F254	R:R:I291	19.5511	15.07	Yes	No	0	8	5
66	R:R:C294	R:R:I291	16.5559	3.27	Yes	No	0	7	5
67	R:R:I225	R:R:T229	15.4979	1.52	No	No	0	8	8
68	R:R:T229	R:R:W230	10.3939	1.21	No	No	0	8	4
69	R:R:I291	R:R:I295	13.9181	1.47	No	No	0	5	7
70	R:R:I295	R:R:I299	15.1333	2.94	No	No	0	7	7
71	R:R:A303	R:R:I299	12.5956	1.62	No	No	0	6	7
72	R:R:A303	R:R:K239	10.0436	3.21	No	No	0	6	7
73	L:L:?6	R:R:T261	10.9729	3.53	Yes	Yes	1	0	4
74	L:L:K2	R:R:F275	14.8545	2.48	Yes	Yes	8	0	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F44	R:R:V286	2.62	0	No	Yes	7	5	2	1
L:L:?4	R:R:I96	2.68	0	Yes	No	0	5	0	1
L:L:?4	R:R:H100	14.5	0	Yes	No	0	4	0	1
R:R:G189	R:R:R175	4.5	0	No	Yes	4	5	1	2
R:R:D191	R:R:V176	4.38	0	No	No	4	4	1	2
L:L:?1	R:R:R178	5.26	0	Yes	No	0	2	0	1
L:L:?1	R:R:L187	5.99	0	Yes	No	0	4	0	1
L:L:?1	R:R:G189	2.96	0	Yes	No	0	4	0	1
R:R:D191	R:R:S193	2.94	0	No	No	4	4	1	2
L:L:?1	R:R:D191	3.52	0	Yes	No	0	4	0	1
R:R:E199	R:R:Y192	16.83	0	No	No	4	5	1	2
L:L:K2	R:R:E199	5.4	8	Yes	No	0	4	0	1
R:R:W255	R:R:Y258	7.72	6	Yes	No	9	7	2	1
R:R:Q259	R:R:Y258	5.64	0	No	No	8	7	2	1
L:L:?6	R:R:Y258	14.03	1	Yes	No	0	7	0	1
R:R:G262	R:R:T261	3.64	1	No	Yes	5	4	1	1
R:R:C285	R:R:T261	8.45	0	No	Yes	6	4	2	1
L:L:?6	R:R:T261	3.53	1	Yes	Yes	0	4	0	1
L:L:?6	R:R:G262	4.09	1	Yes	No	0	5	0	1
R:R:D282	R:R:M265	6.93	1	Yes	No	4	4	1	2
R:R:F275	R:R:P270	4.33	8	Yes	No	3	3	1	2
R:R:F275	R:R:K279	7.44	8	Yes	No	3	4	1	1
L:L:K2	R:R:F275	2.48	8	Yes	Yes	0	3	0	1
L:L:K2	R:R:K279	2.87	8	Yes	No	0	4	0	1
L:L:P3	R:R:K279	3.35	0	No	No	0	4	0	1
R:R:D282	R:R:V286	4.38	1	Yes	Yes	4	5	1	1
L:L:W5	R:R:D282	5.58	1	Yes	Yes	0	4	0	1
L:L:?6	R:R:D282	8.66	1	Yes	Yes	0	4	0	1
L:L:W5	R:R:V286	22.07	1	Yes	Yes	0	5	0	1
L:L:?6	R:R:V286	5.94	1	Yes	Yes	0	5	0	1
R:R:T261	R:R:V260	1.59	1	Yes	No	4	6	1	2
R:R:F275	R:R:S272	1.32	8	Yes	No	3	4	1	2
L:L:?4	R:R:L92	1.3	0	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y67_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	253
Number of Links	270
Number of Hubs	29
Number of Links mediated by Hubs	108
Number of Communities	8
Number of Nodes involved in Communities	27
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	30832
Length Of Smallest Path	3
Average Path Length	15.2991
Length of Longest Path	35
Minimum Path Strength	1.26
Average Path Strength	5.40385
Maximum Path Strength	16.05
Minimum Path Correlation	0.7
Average Path Correlation	0.92088
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	44.7351
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.8414
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • opsonin receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement component C5a receptor activity • immune receptor activity • G protein-coupled receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response • immune system process • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of immune response • activation of immune response • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • taxis • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • cognition • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • defense response • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • cellular defense response • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • apical part of cell • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • intracellular vesicle • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951134
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ZAL
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	ZAL
Name	3-cyclohexyl-D-alanine
Synonyms
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	25322977
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	DAR
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DAR
Name	D-arginine
Synonyms	(2R)-2-amino-5-guanidinopentanoic acid
Identifier
Formula	C6 H15 N4 O2
Molecular Weight	175.209
SMILES
PubChem	58433835
Formal Charge	1
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>7Y67_nogp_Chain_R T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L A L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

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