psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L679	L:L:L738	4.15	No	No	0	4	3
2	L:L:Q680	R:R:Y181	30.44	No	No	0	1	1
3	L:L:I683	L:L:V734	3.07	No	No	0	6	3
4	L:L:I683	R:R:F182	12.56	No	Yes	0	6	3
5	L:L:E684	L:L:Y700	3.37	No	No	0	1	4
6	L:L:E730	L:L:I686	4.1	No	No	0	2	3
7	L:L:I686	L:L:V734	4.61	No	No	0	3	3
8	L:L:V695	L:L:Y690	10.09	No	No	0	1	5
9	L:L:A727	L:L:Y690	4	No	No	0	6	5
10	L:L:E730	L:L:Y690	11.22	No	No	0	2	5
11	L:L:H692	L:L:V694	11.07	No	No	0	1	1
12	L:L:H692	L:L:V695	5.54	No	No	6	1	1
13	L:L:H692	L:L:R723	4.51	No	No	6	1	1
14	L:L:R723	L:L:V695	3.92	No	No	6	1	1
15	L:L:C698	L:L:C724	7.28	No	No	0	9	9
16	L:L:C698	R:R:V26	6.83	No	No	0	9	5
17	L:L:C699	L:L:C731	7.28	No	No	0	9	9
18	L:L:D701	R:R:P25	3.22	Yes	No	0	3	8
19	L:L:D701	R:R:V26	7.3	Yes	No	0	3	5
20	L:L:F728	L:L:G702	9.03	Yes	No	0	9	8
21	L:L:A703	R:R:F182	6.93	No	Yes	0	7	3
22	L:L:R739	L:L:V705	9.15	No	No	0	6	4
23	L:L:V705	R:R:E180	4.28	No	Yes	0	4	1
24	L:L:D708	L:L:N706	5.39	No	No	0	3	6
25	L:L:N706	L:L:R714	12.05	No	Yes	0	6	7
26	L:L:N706	R:R:T29	4.39	No	No	0	6	5
27	L:L:N707	R:R:L276	5.49	No	No	0	3	3
28	L:L:D708	R:R:R34	7.15	No	Yes	0	3	2
29	L:L:E709	L:L:Q713	17.84	No	No	0	5	3
30	L:L:E709	L:L:R714	5.82	No	Yes	0	5	7
31	L:L:E709	L:L:R717	10.47	No	No	0	5	7
32	L:L:C711	L:L:C732	7.28	No	No	0	9	9
33	L:L:F728	L:L:R714	5.34	Yes	Yes	3	9	7
34	L:L:C732	L:L:R714	4.18	No	Yes	3	9	7
35	L:L:R714	R:R:D27	5.96	Yes	Yes	3	7	9
36	L:L:A715	L:L:F728	4.16	No	Yes	0	5	9
37	L:L:R717	R:R:K28	3.71	No	No	0	7	3
38	L:L:C724	L:L:I718	3.27	No	No	0	9	4
39	L:L:I718	L:L:I725	4.42	No	No	0	4	4
40	L:L:F728	L:L:I718	5.02	Yes	No	0	9	4
41	L:L:L720	L:L:S719	4.5	No	No	0	1	2
42	L:L:C724	L:L:L720	4.76	No	No	0	9	1
43	L:L:G721	L:L:P722	4.06	No	No	0	1	1
44	L:L:C732	L:L:F728	4.19	No	Yes	3	9	9
45	L:L:F728	R:R:D27	5.97	Yes	Yes	3	9	9
46	L:L:I742	R:R:R178	6.26	No	No	0	3	2
47	L:L:S743	R:R:D191	5.89	No	No	0	3	4
48	L:L:S743	R:R:H194	11.16	No	No	0	3	1
49	L:L:H744	R:R:R178	7.9	Yes	No	0	3	2
50	L:L:H744	R:R:G189	4.77	Yes	No	0	3	4
51	L:L:H744	R:R:D191	6.3	Yes	No	0	3	4
52	L:L:K745	R:R:E199	6.75	No	No	0	4	4
53	L:L:K745	R:R:F275	6.2	No	Yes	0	4	3
54	L:L:D746	R:R:H100	5.04	No	No	0	1	4
55	L:L:D746	R:R:K279	5.53	No	No	0	1	4
56	L:L:M747	R:R:R175	3.72	No	Yes	2	4	5
57	L:L:M747	R:R:V190	6.09	No	No	2	4	5
58	L:L:Q748	R:R:I96	4.12	Yes	No	8	5	5
59	L:L:Q748	R:R:H100	8.65	Yes	No	0	5	4
60	L:L:Q748	R:R:D282	20.88	Yes	No	0	5	4
61	L:L:Q748	R:R:S283	8.66	Yes	No	8	5	4
62	L:L:L749	R:R:L92	9.69	No	No	0	8	6
63	L:L:L749	R:R:P113	4.93	No	No	0	8	6
64	L:L:G750	R:R:I116	3.53	No	No	0	6	6
65	L:L:R751	R:R:L117	3.64	Yes	No	0	9	4
66	L:L:R751	R:R:Y258	24.69	Yes	No	0	9	7
67	L:L:R751	R:R:T261	5.17	Yes	No	0	9	4
68	L:L:R751	R:R:D282	10.72	Yes	No	0	9	4
69	R:R:P25	R:R:T24	3.5	No	No	0	8	4
70	R:R:D27	R:R:P25	4.83	Yes	No	0	9	8
71	R:R:D27	R:R:T29	13.01	Yes	No	0	9	5
72	R:R:H99	R:R:N31	11.48	No	No	0	2	1
73	R:R:D37	R:R:R34	7.15	No	Yes	0	4	2
74	R:R:K280	R:R:R34	13.61	No	Yes	0	2	2
75	R:R:P36	R:R:V35	3.53	No	No	0	3	3
76	R:R:D37	R:R:S283	4.42	No	No	0	4	4
77	R:R:A40	R:R:S287	3.42	No	No	0	6	4
78	R:R:F93	R:R:L41	12.18	No	No	0	7	5
79	R:R:I96	R:R:L41	5.71	No	No	0	5	5
80	R:R:I43	R:R:S287	6.19	No	No	0	5	4
81	R:R:F44	R:R:V286	3.93	No	No	0	7	5
82	R:R:F44	R:R:S287	13.21	No	No	0	7	4
83	R:R:F44	R:R:Y290	4.13	No	No	0	7	7
84	R:R:F48	R:R:V52	5.24	Yes	No	0	6	5
85	R:R:F48	R:R:L89	4.87	Yes	No	0	6	7
86	R:R:F48	R:R:P90	4.33	Yes	No	0	6	9
87	R:R:C294	R:R:V50	3.42	Yes	No	0	7	6
88	R:R:D82	R:R:N55	6.73	Yes	No	0	9	9
89	R:R:N55	R:R:P297	8.15	No	No	0	9	9
90	R:R:A79	R:R:V58	3.39	No	No	0	8	8
91	R:R:V58	R:R:Y300	6.31	No	Yes	0	8	9
92	R:R:L76	R:R:V59	4.47	No	No	0	6	7
93	R:R:A79	R:R:V59	3.39	No	No	0	8	7
94	R:R:F64	R:R:W60	16.04	No	No	9	4	4
95	R:R:S314	R:R:W60	9.88	No	No	9	4	4
96	R:R:F307	R:R:V61	7.87	Yes	No	0	9	6
97	R:R:R310	R:R:V61	3.92	No	No	0	4	6
98	R:R:L76	R:R:T62	7.37	No	No	0	6	6
99	R:R:T62	R:R:Y300	3.75	No	Yes	0	6	9
100	R:R:F64	R:R:S314	15.85	No	No	9	4	4
101	R:R:E65	R:R:R68	5.82	No	No	0	5	7
102	R:R:E65	R:R:R310	5.82	No	No	0	5	4
103	R:R:I70	R:R:R148	8.77	No	Yes	0	6	7
104	R:R:G149	R:R:I70	3.53	No	No	0	5	6
105	R:R:F75	R:R:N71	8.46	No	No	0	8	7
106	R:R:A153	R:R:I73	3.25	No	No	0	7	6
107	R:R:I73	R:R:W154	16.44	No	No	0	6	3
108	R:R:T129	R:R:W74	4.85	No	Yes	0	6	7
109	R:R:I130	R:R:W74	4.7	No	Yes	0	8	7
110	R:R:D133	R:R:W74	12.28	No	Yes	0	8	7
111	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
112	R:R:F75	R:R:Y300	20.63	No	Yes	0	8	9
113	R:R:L126	R:R:N77	5.49	Yes	Yes	5	7	9
114	R:R:N77	R:R:W154	5.65	Yes	No	0	9	3
115	R:R:C157	R:R:N77	11.02	No	Yes	5	6	9
116	R:R:N77	R:R:W161	5.65	Yes	Yes	5	9	9
117	R:R:L126	R:R:L78	5.54	Yes	No	0	7	9
118	R:R:L127	R:R:L78	4.15	No	No	0	8	9
119	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
120	R:R:C293	R:R:D82	9.34	No	Yes	0	8	9
121	R:R:D82	R:R:N296	6.73	Yes	No	0	9	9
122	R:R:F83	R:R:L87	12.18	No	No	0	8	4
123	R:R:L84	R:R:N119	10.98	No	No	0	6	9
124	R:R:C293	R:R:S85	3.44	No	No	0	8	6
125	R:R:L89	R:R:Y290	9.38	No	No	0	7	7
126	R:R:I91	R:R:L112	5.71	No	No	0	6	5
127	R:R:L92	R:R:Y290	4.69	No	No	0	6	7
128	R:R:F93	R:R:V97	3.93	No	No	0	7	3
129	R:R:I96	R:R:S283	3.1	No	No	8	5	4
130	R:R:P103	R:R:Q98	3.16	No	No	0	3	4
131	R:R:H101	R:R:P103	3.05	No	No	0	4	3
132	R:R:H101	R:R:K185	5.24	No	Yes	0	4	3
133	R:R:F104	R:R:W102	19.04	No	No	0	7	8
134	R:R:C109	R:R:W102	5.22	Yes	No	2	9	8
135	R:R:C188	R:R:W102	6.53	Yes	No	2	9	8
136	R:R:F104	R:R:P103	8.67	No	No	0	7	3
137	R:R:C109	R:R:V177	3.42	Yes	No	0	9	4
138	R:R:C109	R:R:C188	3.64	Yes	Yes	2	9	9
139	R:R:L112	R:R:P113	3.28	No	No	0	5	6
140	R:R:P113	R:R:R175	10.09	No	Yes	0	6	5
141	R:R:S114	R:R:T168	3.2	No	No	10	5	6
142	R:R:S114	R:R:S171	6.52	No	No	10	5	5
143	R:R:F172	R:R:S114	17.18	No	No	0	4	5
144	R:R:L117	R:R:Y121	9.38	No	No	0	4	7
145	R:R:L118	R:R:W161	4.56	No	Yes	0	5	9
146	R:R:L118	R:R:L165	4.15	No	No	0	5	4
147	R:R:L118	R:R:T168	5.9	No	No	0	5	6
148	R:R:M120	R:R:W255	3.49	No	Yes	0	7	9
149	R:R:L167	R:R:Y121	4.69	No	No	0	4	7
150	R:R:R206	R:R:Y121	8.23	No	No	0	6	7
151	R:R:A122	R:R:W161	7.78	No	Yes	0	6	9
152	R:R:I124	R:R:P214	3.39	No	Yes	0	8	9
153	R:R:F251	R:R:I124	3.77	Yes	No	1	9	8
154	R:R:I124	R:R:W255	11.74	No	Yes	1	8	9
155	R:R:C157	R:R:L126	3.17	No	Yes	5	6	7
156	R:R:L126	R:R:W161	3.42	Yes	Yes	5	7	9
157	R:R:L127	R:R:N296	10.98	No	No	0	8	9
158	R:R:I130	R:R:R134	6.26	No	No	0	8	9
159	R:R:L218	R:R:S131	7.51	No	No	1	8	9
160	R:R:C221	R:R:S131	5.16	No	No	0	6	9
161	R:R:S131	R:R:Y222	13.99	No	Yes	1	9	8
162	R:R:D133	R:R:L137	6.79	No	No	4	8	8
163	R:R:D133	R:R:R148	11.91	No	Yes	4	8	7
164	R:R:R134	R:R:Y222	6.17	No	Yes	0	9	8
165	R:R:F135	R:R:F139	16.08	Yes	Yes	11	8	7
166	R:R:C221	R:R:F135	6.98	No	Yes	0	6	8
167	R:R:F135	R:R:F224	5.36	Yes	No	11	8	3
168	R:R:F135	R:R:I225	3.77	Yes	No	0	8	8
169	R:R:K140	R:R:L136	4.23	No	No	0	6	5
170	R:R:L136	R:R:W143	3.42	No	No	0	5	5
171	R:R:C144	R:R:L136	4.76	No	No	0	5	5
172	R:R:C144	R:R:L137	4.76	No	No	4	5	8
173	R:R:L137	R:R:R148	13.36	No	Yes	4	8	7
174	R:R:F139	R:R:V138	3.93	Yes	No	0	7	8
175	R:R:I225	R:R:V138	12.29	No	No	0	8	8
176	R:R:F139	R:R:F224	3.22	Yes	No	11	7	3
177	R:R:F139	R:R:R228	23.52	Yes	No	0	7	5
178	R:R:F147	R:R:W143	6.01	No	No	0	4	5
179	R:R:C144	R:R:R148	4.18	No	Yes	4	5	7
180	R:R:F147	R:R:N146	4.83	No	No	0	4	5
181	R:R:L167	R:R:L209	5.54	No	No	0	4	4
182	R:R:S171	R:R:T168	3.2	No	No	10	5	6
183	R:R:I169	R:R:P170	3.39	No	No	0	3	8
184	R:R:P170	R:R:V202	3.53	No	No	0	8	5
185	R:R:L173	R:R:Y174	12.89	No	No	0	4	4
186	R:R:Y174	R:R:Y192	9.93	No	No	0	4	5
187	R:R:R198	R:R:Y174	9.26	No	No	0	3	4
188	R:R:C188	R:R:R175	5.57	Yes	Yes	2	9	5
189	R:R:R175	R:R:V190	5.23	Yes	No	2	5	5
190	R:R:E179	R:R:Y181	13.47	No	No	0	2	1
191	R:R:E180	R:R:P183	11	Yes	No	0	1	4
192	R:R:E180	R:R:K185	10.8	Yes	Yes	7	1	3
193	R:R:E180	R:R:L187	9.28	Yes	No	7	1	4
194	R:R:F182	R:R:P183	4.33	Yes	No	0	3	4
195	R:R:K185	R:R:L187	5.64	Yes	No	7	3	4
196	R:R:V190	R:R:Y192	7.57	No	No	0	5	5
197	R:R:E199	R:R:Y192	16.83	No	No	0	4	5
198	R:R:D195	R:R:R198	10.72	No	No	0	3	3
199	R:R:E199	R:R:S266	7.19	No	No	0	4	5
200	R:R:F267	R:R:R200	18.17	No	No	0	4	3
201	R:R:A203	R:R:S266	3.42	No	No	0	5	5
202	R:R:F267	R:R:I204	5.02	No	No	0	4	3
203	R:R:L207	R:R:L212	4.15	No	No	0	5	4
204	R:R:L207	R:R:Q259	5.32	No	No	0	5	8
205	R:R:I263	R:R:L207	4.28	No	No	0	5	5
206	R:R:G210	R:R:P214	4.06	No	Yes	0	6	9
207	R:R:F211	R:R:L256	3.65	No	Yes	0	8	5
208	R:R:F211	R:R:Q259	12.88	No	No	0	8	8
209	R:R:P214	R:R:W213	5.4	Yes	No	0	9	5
210	R:R:T217	R:R:W213	6.06	No	No	0	5	5
211	R:R:F251	R:R:L215	3.65	Yes	No	0	9	5
212	R:R:F252	R:R:L215	4.87	No	No	0	5	5
213	R:R:L218	R:R:Y222	7.03	No	Yes	1	8	8
214	R:R:F251	R:R:L218	6.09	Yes	No	1	9	8
215	R:R:F224	R:R:I220	6.28	No	No	0	3	3
216	R:R:V244	R:R:Y222	12.62	No	Yes	0	7	8
217	R:R:L226	R:R:T240	4.42	No	No	0	5	7
218	R:R:L226	R:R:L241	4.15	No	No	0	5	6
219	R:R:L226	R:R:V244	11.92	No	No	0	5	7
220	R:R:T229	R:R:T235	7.85	No	No	0	8	4
221	R:R:R236	R:R:W230	13.99	No	No	0	5	4
222	R:R:I295	R:R:S250	3.1	No	No	0	7	6
223	R:R:F251	R:R:W255	14.03	Yes	Yes	1	9	9
224	R:R:F251	R:R:N292	3.62	Yes	No	1	9	9
225	R:R:F252	R:R:L256	7.31	No	Yes	0	5	5
226	R:R:F254	R:R:F288	13.93	No	No	12	8	8
227	R:R:F254	R:R:I291	18.84	No	Yes	12	8	5
228	R:R:A289	R:R:W255	3.89	No	Yes	0	8	9
229	R:R:N292	R:R:W255	10.17	No	Yes	1	9	9
230	R:R:L256	R:R:P257	3.28	Yes	No	0	5	9
231	R:R:Q259	R:R:Y258	7.89	No	No	0	8	7
232	R:R:A289	R:R:Y258	4	No	No	0	8	7
233	R:R:G262	R:R:T261	3.64	No	No	0	5	4
234	R:R:C285	R:R:T261	6.76	No	No	0	6	4
235	R:R:F267	R:R:I263	5.02	No	No	0	4	5
236	R:R:L278	R:R:M264	11.31	No	No	0	4	4
237	R:R:L278	R:R:M265	4.24	No	No	0	4	4
238	R:R:D282	R:R:M265	5.54	No	No	0	4	4
239	R:R:L268	R:R:T274	4.42	No	No	0	2	1
240	R:R:F275	R:R:L268	3.65	Yes	No	0	3	2
241	R:R:E269	R:R:P270	3.14	No	No	0	3	3
242	R:R:E269	R:R:S271	7.19	No	No	0	3	4
243	R:R:E269	R:R:S272	7.19	No	No	0	3	4
244	R:R:F275	R:R:P270	5.78	Yes	No	0	3	3
245	R:R:S272	R:R:T274	3.2	No	No	0	4	1
246	R:R:F275	R:R:K279	7.44	Yes	No	0	3	4
247	R:R:L277	R:R:L281	4.15	No	No	0	1	5
248	R:R:F288	R:R:I291	5.02	No	Yes	12	8	5
249	R:R:N292	R:R:N296	5.45	No	No	0	9	9
250	R:R:R310	R:R:Y300	6.17	No	Yes	0	4	9
251	R:R:F307	R:R:V301	15.73	Yes	No	0	9	6
252	R:R:G309	R:R:Q308	3.29	No	No	0	5	8
253	R:R:N119	R:R:S85	2.98	No	No	0	9	6
254	R:R:L163	R:R:V159	2.98	No	No	0	4	1
255	R:R:L209	R:R:V205	2.98	No	No	0	4	3
256	R:R:L212	R:R:V208	2.98	No	No	0	4	4
257	R:R:L241	R:R:V245	2.98	No	No	0	6	4
258	R:R:L256	R:R:V260	2.98	Yes	No	0	5	6
259	R:R:L215	R:R:T219	2.95	No	No	0	5	4
260	R:R:I291	R:R:I43	2.94	Yes	No	0	5	5
261	R:R:I291	R:R:I295	2.94	Yes	No	0	5	7
262	R:R:I295	R:R:I299	2.94	No	No	0	7	7
263	R:R:P36	R:R:R34	2.88	No	Yes	0	3	2
264	L:L:L749	R:R:I116	2.85	No	No	0	8	6
265	R:R:I111	R:R:L115	2.85	No	No	0	4	5
266	L:L:Q713	L:L:T710	2.83	No	No	0	3	7
267	R:R:I142	R:R:N146	2.83	No	No	0	5	5
268	L:L:K682	L:L:L738	2.82	No	No	0	2	3
269	R:R:E65	R:R:T69	2.82	No	No	0	5	7
270	L:L:H744	R:R:V176	2.77	Yes	No	0	3	4
271	R:R:L33	R:R:L41	2.77	No	No	0	4	5
272	R:R:H101	R:R:V186	2.77	No	No	0	4	6
273	R:R:A108	R:R:F104	2.77	No	No	0	5	7
274	R:R:L22	R:R:N23	2.75	No	No	0	3	4
275	L:L:E685	L:L:K682	2.7	No	No	0	3	2
276	R:R:F172	R:R:S110	2.64	No	No	0	4	6
277	R:R:H99	R:R:K185	2.62	No	Yes	0	2	3
278	R:R:R206	R:R:V202	2.62	No	No	0	6	5
279	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
280	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
281	R:R:V247	R:R:Y222	2.52	No	Yes	0	7	8
282	R:R:V248	R:R:Y222	2.52	No	Yes	0	7	8
283	R:R:F172	R:R:I111	2.51	No	No	0	4	4
284	R:R:F288	R:R:I253	2.51	No	No	0	8	5
285	L:L:L679	R:R:F182	2.44	No	Yes	0	4	3
286	R:R:F307	R:R:L57	2.44	Yes	No	0	9	5
287	R:R:F83	R:R:N55	2.42	No	No	0	8	9
288	R:R:D195	R:R:R197	2.38	No	No	0	3	1
289	R:R:L125	R:R:W213	2.28	No	No	0	6	5
290	R:R:L152	R:R:W143	2.28	No	No	0	3	5
291	R:R:F75	R:R:R134	2.14	No	No	0	8	9
292	R:R:G105	R:R:G106	2.11	No	No	0	7	3
293	R:R:G54	R:R:P297	2.03	No	No	0	7	9
294	R:R:C86	R:R:G51	1.96	No	No	0	5	8
295	R:R:C294	R:R:G51	1.96	Yes	No	0	7	8
296	R:R:C109	R:R:G106	1.96	Yes	No	0	9	3
297	R:R:C188	R:R:G189	1.96	Yes	No	0	9	4
298	R:R:P183	R:R:P184	1.95	No	No	0	4	5
299	R:R:A128	R:R:P214	1.87	No	Yes	0	7	9
300	R:R:C293	R:R:C86	1.82	No	No	0	8	5
301	R:R:A122	R:R:A164	1.79	No	No	0	6	7
302	R:R:P273	R:R:S272	1.78	No	No	0	2	4
303	L:L:C711	L:L:S736	1.72	No	No	0	9	3
304	L:L:G721	L:L:L720	1.71	No	No	0	1	1
305	R:R:C294	R:R:V47	1.71	Yes	No	0	7	6
306	R:R:G54	R:R:L53	1.71	No	No	0	7	4
307	R:R:G162	R:R:L165	1.71	No	No	0	4	4
308	R:R:A303	R:R:V243	1.7	No	No	0	6	7
309	R:R:I142	R:R:P141	1.69	No	No	0	5	8
310	L:L:A715	L:L:T729	1.68	No	No	0	5	1
311	R:R:A72	R:R:T62	1.68	No	No	0	7	6
312	R:R:A72	R:R:T69	1.68	No	No	0	7	7
313	R:R:A160	R:R:T129	1.68	No	No	0	6	6
314	L:L:C731	L:L:I686	1.64	No	No	0	9	3
315	R:R:C294	R:R:I298	1.64	Yes	No	0	7	7
316	R:R:G306	R:R:Q305	1.64	No	No	0	7	6
317	R:R:G306	R:R:Q308	1.64	No	No	0	7	8
318	R:R:A66	R:R:I73	1.62	No	No	0	5	6
319	R:R:A150	R:R:I70	1.62	No	No	0	3	6
320	R:R:A88	R:R:I116	1.62	No	No	0	6	6
321	R:R:A246	R:R:I299	1.62	No	No	0	5	7
322	R:R:A249	R:R:I253	1.62	No	No	0	4	5
323	R:R:A66	R:R:K67	1.61	No	No	0	5	6
324	R:R:V42	R:R:V46	1.6	No	No	0	5	4
325	R:R:V46	R:R:V50	1.6	No	No	0	4	6
326	R:R:V59	R:R:V80	1.6	No	No	0	7	5
327	R:R:S237	R:R:T240	1.6	No	No	0	7	7
328	R:R:V243	R:R:V247	1.6	No	No	0	7	7
329	L:L:T729	L:L:V733	1.59	No	No	0	1	3
330	R:R:T229	R:R:V138	1.59	No	No	0	8	8
331	R:R:C285	R:R:L281	1.59	No	No	0	6	5
332	R:R:A63	R:R:L76	1.58	No	No	0	3	6
333	R:R:T219	R:R:T223	1.57	No	No	0	4	2
334	L:L:C704	L:L:D701	1.56	No	Yes	0	1	3
335	R:R:I38	R:R:V42	1.54	No	No	0	5	5
336	R:R:I155	R:R:V159	1.54	No	No	0	2	1
337	R:R:I298	R:R:V302	1.54	No	No	0	7	6
338	R:R:K239	R:R:S237	1.53	No	No	0	7	7
339	L:L:A687	L:L:E684	1.51	No	No	0	6	1
340	R:R:N31	R:R:S30	1.49	No	No	0	1	4
341	R:R:L39	R:R:V35	1.49	No	No	0	5	3
342	R:R:L311	R:R:V61	1.49	No	No	0	6	6
343	R:R:L227	R:R:T223	1.47	No	No	0	4	2
344	L:L:Q737	L:L:V733	1.43	No	No	0	3	3
345	R:R:I43	R:R:L284	1.43	No	No	0	5	4
346	R:R:I169	R:R:L166	1.43	No	No	0	3	4
347	R:R:H100	R:R:S95	1.39	No	No	0	4	4
348	L:L:D701	L:L:K697	1.38	Yes	No	0	3	1
349	L:L:A735	L:L:R739	1.38	No	No	0	6	6
350	R:R:L125	R:R:L163	1.38	No	No	0	6	4
351	L:L:E730	L:L:K726	1.35	No	No	0	2	1
352	R:R:R232	R:R:T235	1.29	No	No	0	5	4
353	R:R:K196	R:R:R200	1.24	No	No	0	2	3
354	R:R:F48	R:R:L49	1.22	Yes	No	0	6	4
355	R:R:T229	R:R:W230	1.21	No	No	0	8	4
356	R:R:T240	R:R:W230	1.21	No	No	0	7	4
357	R:R:L311	R:R:R312	1.21	No	No	0	6	5
358	L:L:Q680	R:R:F182	1.17	No	Yes	0	1	3
359	R:R:F307	R:R:Q308	1.17	Yes	No	0	9	8
360	L:L:D701	L:L:Y700	1.15	Yes	No	0	3	4
361	R:R:L311	R:R:W60	1.14	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:D701	2.922	5	0	3
2	L:L:R714	6.67	5	3	7
3	L:L:F728	5.61833	6	3	9
4	L:L:H744	5.435	4	0	3
5	L:L:Q748	10.5775	4	8	5
6	L:L:R751	11.055	4	0	9
7	R:R:D27	7.4425	4	3	9
8	R:R:R34	7.6975	4	0	2
9	R:R:F48	3.915	4	0	6
10	R:R:W74	5.922	5	0	7
11	R:R:N77	6.9525	4	5	9
12	R:R:D82	7.1725	4	0	9
13	R:R:C109	3.56	4	2	9
14	R:R:L126	4.405	4	5	7
15	R:R:F135	8.0475	4	11	8
16	R:R:F139	11.6875	4	11	7
17	R:R:R148	9.555	4	4	7
18	R:R:W161	4.8	5	5	9
19	R:R:R175	6.1525	4	2	5
20	R:R:E180	8.84	4	7	1
21	R:R:F182	5.486	5	0	3
22	R:R:K185	6.075	4	7	3
23	R:R:C188	4.425	4	2	9
24	R:R:P214	3.68	4	0	9
25	R:R:Y222	7.475	6	1	8
26	R:R:F251	6.232	5	1	9
27	R:R:W255	8.664	5	1	9
28	R:R:L256	4.305	4	0	5
29	R:R:F275	5.7675	4	0	3
30	R:R:I291	7.435	4	12	5
31	R:R:C294	2.1825	4	0	7
32	R:R:Y300	9.215	4	0	9
33	R:R:F307	6.8025	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I683	R:R:F182	13.645	12.56	No	Yes	0	6	3
2	L:L:I683	L:L:V734	12.6748	3.07	No	No	0	6	3
3	L:L:D701	R:R:P25	13.9902	3.22	Yes	No	0	3	8
4	R:R:D27	R:R:P25	17.9186	4.83	Yes	No	0	9	8
5	L:L:N706	L:L:R714	31.6826	12.05	No	Yes	0	6	7
6	L:L:D708	L:L:N706	43.0629	5.39	No	No	0	3	6
7	L:L:D708	R:R:R34	43.8426	7.15	No	Yes	0	3	2
8	R:R:D37	R:R:R34	47.8692	7.15	No	Yes	0	4	2
9	R:R:D37	R:R:S283	48.6548	4.42	No	No	0	4	4
10	L:L:Q748	R:R:S283	48.6459	8.66	Yes	No	8	5	4
11	L:L:Q748	R:R:H100	83.5486	8.65	Yes	No	0	5	4
12	L:L:D746	R:R:H100	82.6498	5.04	No	No	0	1	4
13	L:L:D746	R:R:K279	82.1915	5.53	No	No	0	1	4
14	R:R:F275	R:R:K279	81.7273	7.44	Yes	No	0	3	4
15	L:L:K745	R:R:F275	76.7573	6.2	No	Yes	0	4	3
16	L:L:K745	R:R:E199	76.2276	6.75	No	No	0	4	4
17	R:R:E199	R:R:Y192	74.6027	16.83	No	No	0	4	5
18	R:R:V190	R:R:Y192	71.1922	7.57	No	No	0	5	5
19	R:R:R175	R:R:V190	69.7607	5.23	Yes	No	2	5	5
20	R:R:C188	R:R:R175	49.3899	5.57	Yes	Yes	2	9	5
21	R:R:C188	R:R:W102	38.3281	6.53	Yes	No	2	9	8
22	R:R:F104	R:R:W102	37.9471	19.04	No	No	0	7	8
23	R:R:F104	R:R:P103	36.2151	8.67	No	No	0	7	3
24	R:R:H101	R:R:P103	34.4593	3.05	No	No	0	4	3
25	R:R:H101	R:R:K185	32.6796	5.24	No	Yes	0	4	3
26	R:R:E180	R:R:K185	28.0519	10.8	Yes	Yes	7	1	3
27	R:R:E180	R:R:P183	24.4063	11	Yes	No	0	1	4
28	R:R:F182	R:R:P183	22.4957	4.33	Yes	No	0	3	4
29	L:L:N706	R:R:T29	10.5976	4.39	No	No	0	6	5
30	L:L:I686	L:L:V734	11.6511	4.61	No	No	0	3	3
31	L:L:F728	L:L:R714	13.6986	5.34	Yes	Yes	3	9	7
32	L:L:Q748	R:R:D282	99.3453	20.88	Yes	No	0	5	4
33	R:R:P113	R:R:R175	29.1322	10.09	No	Yes	0	6	5
34	L:L:L749	R:R:P113	26.3466	4.93	No	No	0	8	6
35	L:L:L749	R:R:L92	22.5493	9.69	No	No	0	8	6
36	L:L:R751	R:R:D282	99.6667	10.72	Yes	No	0	9	4
37	L:L:R751	R:R:L117	10.6214	3.64	Yes	No	0	9	4
38	L:L:R751	R:R:Y258	100	24.69	Yes	No	0	9	7
39	R:R:L92	R:R:Y290	21.585	4.69	No	No	0	6	7
40	R:R:F44	R:R:Y290	15.6747	4.13	No	No	0	7	7
41	R:R:F44	R:R:S287	13.6569	13.21	No	No	0	7	4
42	R:R:I43	R:R:S287	11.6154	6.19	No	No	0	5	4
43	R:R:A289	R:R:Y258	96.5597	4	No	No	0	8	7
44	R:R:A289	R:R:W255	96.4466	3.89	No	Yes	0	8	9
45	R:R:N292	R:R:W255	29.528	10.17	No	Yes	1	9	9
46	R:R:N292	R:R:N296	40.1434	5.45	No	No	0	9	9
47	R:R:D82	R:R:N296	23.1087	6.73	Yes	No	0	9	9
48	R:R:C293	R:R:D82	15.0378	9.34	No	Yes	0	8	9
49	R:R:C293	R:R:C86	10.8595	1.82	No	No	0	8	5
50	R:R:F251	R:R:W255	62.0052	14.03	Yes	Yes	1	9	9
51	R:R:F251	R:R:L218	73.8051	6.09	Yes	No	1	9	8
52	R:R:L218	R:R:Y222	60.7375	7.03	No	Yes	1	8	8
53	R:R:R134	R:R:Y222	53.4909	6.17	No	Yes	0	9	8
54	R:R:F75	R:R:R134	30.0815	2.14	No	No	0	8	9
55	R:R:F75	R:R:Y300	28.3465	20.63	No	Yes	0	8	9
56	R:R:R310	R:R:Y300	17.1686	6.17	No	Yes	0	4	9
57	R:R:R310	R:R:V61	13.3444	3.92	No	No	0	4	6
58	R:R:I130	R:R:R134	32.2451	6.26	No	No	0	8	9
59	R:R:I130	R:R:W74	31.4803	4.7	No	Yes	0	8	7
60	R:R:D133	R:R:W74	23.817	12.28	No	Yes	0	8	7
61	R:R:D133	R:R:R148	12.9546	11.91	No	Yes	4	8	7
62	R:R:L127	R:R:N296	19.3352	10.98	No	No	0	8	9
63	R:R:L127	R:R:L78	18.5495	4.15	No	No	0	8	9
64	R:R:L126	R:R:L78	17.74	5.54	Yes	No	0	7	9
65	R:R:L126	R:R:W161	12.2463	3.42	Yes	Yes	5	7	9
66	R:R:L118	R:R:W161	11.3952	4.56	No	Yes	0	5	9
67	R:R:I124	R:R:P214	10.7107	3.39	No	Yes	0	8	9
68	R:R:L218	R:R:S131	12.5975	7.51	No	No	1	8	9
69	R:R:C221	R:R:S131	13.8474	5.16	No	No	0	6	9
70	R:R:C221	R:R:F135	12.8742	6.98	No	Yes	0	6	8
71	R:R:C144	R:R:L136	16.0645	4.76	No	No	0	5	5
72	R:R:L136	R:R:W143	12.0767	3.42	No	No	0	5	5
73	R:R:Q259	R:R:Y258	12.3356	7.89	No	No	0	8	7
74	R:R:V244	R:R:Y222	12.6242	12.62	No	Yes	0	7	8
75	R:R:L226	R:R:V244	11.5916	11.92	No	No	0	5	7
76	R:R:F251	R:R:N292	11.4517	3.62	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q680	R:R:Y181	30.44	0	No	No	1	1	0	1
L:L:I683	R:R:F182	12.56	0	No	Yes	6	3	0	1
L:L:C698	R:R:V26	6.83	0	No	No	9	5	0	1
L:L:D701	R:R:P25	3.22	0	Yes	No	3	8	0	1
L:L:D701	R:R:V26	7.3	0	Yes	No	3	5	0	1
L:L:A703	R:R:F182	6.93	0	No	Yes	7	3	0	1
L:L:V705	R:R:E180	4.28	0	No	Yes	4	1	0	1
L:L:N706	R:R:T29	4.39	0	No	No	6	5	0	1
L:L:N707	R:R:L276	5.49	0	No	No	3	3	0	1
L:L:D708	R:R:R34	7.15	0	No	Yes	3	2	0	1
L:L:R714	R:R:D27	5.96	3	Yes	Yes	7	9	0	1
L:L:R717	R:R:K28	3.71	0	No	No	7	3	0	1
L:L:F728	R:R:D27	5.97	3	Yes	Yes	9	9	0	1
L:L:I742	R:R:R178	6.26	0	No	No	3	2	0	1
L:L:S743	R:R:D191	5.89	0	No	No	3	4	0	1
L:L:S743	R:R:H194	11.16	0	No	No	3	1	0	1
L:L:H744	R:R:R178	7.9	0	Yes	No	3	2	0	1
L:L:H744	R:R:G189	4.77	0	Yes	No	3	4	0	1
L:L:H744	R:R:D191	6.3	0	Yes	No	3	4	0	1
L:L:K745	R:R:E199	6.75	0	No	No	4	4	0	1
L:L:K745	R:R:F275	6.2	0	No	Yes	4	3	0	1
L:L:D746	R:R:H100	5.04	0	No	No	1	4	0	1
L:L:D746	R:R:K279	5.53	0	No	No	1	4	0	1
L:L:M747	R:R:R175	3.72	2	No	Yes	4	5	0	1
L:L:M747	R:R:V190	6.09	2	No	No	4	5	0	1
L:L:Q748	R:R:I96	4.12	8	Yes	No	5	5	0	1
L:L:Q748	R:R:H100	8.65	8	Yes	No	5	4	0	1
L:L:Q748	R:R:D282	20.88	8	Yes	No	5	4	0	1
L:L:Q748	R:R:S283	8.66	8	Yes	No	5	4	0	1
L:L:L749	R:R:L92	9.69	0	No	No	8	6	0	1
L:L:L749	R:R:P113	4.93	0	No	No	8	6	0	1
L:L:G750	R:R:I116	3.53	0	No	No	6	6	0	1
L:L:R751	R:R:L117	3.64	0	Yes	No	9	4	0	1
L:L:R751	R:R:Y258	24.69	0	Yes	No	9	7	0	1
L:L:R751	R:R:T261	5.17	0	Yes	No	9	4	0	1
L:L:R751	R:R:D282	10.72	0	Yes	No	9	4	0	1
R:R:P25	R:R:T24	3.5	0	No	No	8	4	1	2
R:R:D27	R:R:P25	4.83	3	Yes	No	9	8	1	1
R:R:D27	R:R:T29	13.01	3	Yes	No	9	5	1	1
R:R:D37	R:R:R34	7.15	0	No	Yes	4	2	2	1
R:R:K280	R:R:R34	13.61	0	No	Yes	2	2	2	1
R:R:D37	R:R:S283	4.42	0	No	No	4	4	2	1
R:R:I96	R:R:L41	5.71	8	No	No	5	5	1	2
R:R:L92	R:R:Y290	4.69	0	No	No	6	7	1	2
R:R:I96	R:R:S283	3.1	8	No	No	5	4	1	1
R:R:L112	R:R:P113	3.28	0	No	No	5	6	2	1
R:R:P113	R:R:R175	10.09	0	No	Yes	6	5	1	1
R:R:L117	R:R:Y121	9.38	0	No	No	4	7	1	2
R:R:C188	R:R:R175	5.57	2	Yes	Yes	9	5	2	1
R:R:R175	R:R:V190	5.23	2	Yes	No	5	5	1	1
R:R:E179	R:R:Y181	13.47	0	No	No	2	1	2	1
R:R:E180	R:R:P183	11	7	Yes	No	1	4	1	2
R:R:E180	R:R:K185	10.8	7	Yes	Yes	1	3	1	2
R:R:E180	R:R:L187	9.28	7	Yes	No	1	4	1	2
R:R:F182	R:R:P183	4.33	0	Yes	No	3	4	1	2
R:R:K185	R:R:L187	5.64	7	Yes	No	3	4	2	2
R:R:V190	R:R:Y192	7.57	2	No	No	5	5	1	2
R:R:E199	R:R:Y192	16.83	0	No	No	4	5	1	2
R:R:E199	R:R:S266	7.19	0	No	No	4	5	1	2
R:R:Q259	R:R:Y258	7.89	0	No	No	8	7	2	1
R:R:A289	R:R:Y258	4	0	No	No	8	7	2	1
R:R:G262	R:R:T261	3.64	0	No	No	5	4	2	1
R:R:C285	R:R:T261	6.76	0	No	No	6	4	2	1
R:R:D282	R:R:M265	5.54	0	No	No	4	4	1	2
R:R:F275	R:R:L268	3.65	0	Yes	No	3	2	1	2
R:R:F275	R:R:P270	5.78	0	Yes	No	3	3	1	2
R:R:F275	R:R:K279	7.44	0	Yes	No	3	4	1	1
R:R:P36	R:R:R34	2.88	0	No	Yes	3	2	2	1
L:L:L749	R:R:I116	2.85	0	No	No	8	6	0	1
L:L:H744	R:R:V176	2.77	0	Yes	No	3	4	0	1
L:L:L679	R:R:F182	2.44	0	No	Yes	4	3	0	1
R:R:C188	R:R:G189	1.96	2	Yes	No	9	4	2	1
R:R:A88	R:R:I116	1.62	0	No	No	6	6	2	1
R:R:H100	R:R:S95	1.39	0	No	No	4	4	1	2
L:L:Q680	R:R:F182	1.17	0	No	Yes	1	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HK5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.05
Number of Linked Nodes	337
Number of Links	361
Number of Hubs	33
Number of Links mediated by Hubs	132
Number of Communities	12
Number of Nodes involved in Communities	46
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	65885
Length Of Smallest Path	3
Average Path Length	19.0983
Length of Longest Path	47
Minimum Path Strength	1.175
Average Path Strength	7.55827
Maximum Path Strength	21.955
Minimum Path Correlation	0.7
Average Path Correlation	0.951733
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	58.8201
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.1545
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • signaling receptor binding • molecular function activator activity • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • enzyme regulator activity • molecular function inhibitor activity • peptidase regulator activity • enzyme inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • lymphocyte mediated immunity • humoral immune response • positive regulation of biological process • positive regulation of response to stimulus • complement activation • humoral immune response mediated by circulating immunoglobulin • positive regulation of immune response • leukocyte mediated immunity • regulation of immune system process • positive regulation of immune system process • complement activation, classical pathway • immune response • immunoglobulin mediated immune response • adaptive immune response • immune effector process • regulation of response to stimulus • immune system process • B cell mediated immunity • regulation of immune response • activation of immune response • negative regulation of mononuclear cell migration • negative regulation of locomotion • regulation of cell motility • negative regulation of biological process • negative regulation of chemotaxis • macrophage migration • taxis • negative regulation of macrophage chemotaxis • cell migration • regulation of mononuclear cell migration • negative regulation of macrophage migration • negative regulation of cell migration • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • response to external stimulus • leukocyte migration • negative regulation of leukocyte migration • regulation of locomotion • negative regulation of response to external stimulus • negative regulation of cell motility • negative regulation of leukocyte chemotaxis • regulation of response to external stimulus • macrophage chemotaxis • regulation of macrophage migration • negative regulation of cellular process • regulation of cell migration • myeloid leukocyte migration • cell motility • locomotion • cell chemotaxis • regulation of macrophage chemotaxis • negative regulation of response to stimulus • regulation of chemotaxis • negative regulation of immune system process • mononuclear cell migration • leukocyte chemotaxis • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of chemokine production • chemokine production • positive regulation of chemokine production • cell surface receptor signaling pathway • biological process involved in interspecies interaction between organisms • response to biotic stimulus • innate immune response • response to external biotic stimulus • response to other organism • defense response • defense response to symbiont • complement activation, GZMK pathway • defense response to other organism • disruption of cell in another organism • disruption of anatomical structure in another organism • killing of cells of another organism • cell killing • inflammatory response • complement activation, alternative pathway • pore complex • membrane attack complex • other organism cell membrane • other organism part • opsonin receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement component C5a receptor activity • immune receptor activity • G protein-coupled receptor activity • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • immune response-activating cell surface receptor signaling pathway • amyloid-beta clearance • neutrophil chemotaxis • neutrophil migration • granulocyte migration • granulocyte chemotaxis • cognition • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • positive regulation of leukocyte migration • positive regulation of neutrophil migration • positive regulation of macrophage migration • positive regulation of mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular defense response • response to bacterium • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • apical part of cell • basal part of cell • basal plasma membrane • basolateral plasma membrane • intracellular vesicle • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Anaphylotoxins (complement system) • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Anaphylotoxins (complement system) • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	C5a
UniProt	P01031
Sequence	>8HK5_nogp_Chain_L T L Q K K I E E I A A K Y K H S V V K K C C Y D G A C V N N D E T C E Q R A A R I S L G P R C I K A F T E C C V V A S Q L R A N I S H K D M Q L G R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>8HK5_nogp_Chain_R L N T P V D K T S N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KWG	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWX	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.13	2025-11-26	10.1101/2025.05.26.656101
	9KWX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.13	2025-11-26	10.1101/2025.05.26.656101
	9KX6	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.11	2025-11-26	10.1101/2025.05.26.656101
	9KX6 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.11	2025-11-26	10.1101/2025.05.26.656101
	9KXS	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-	Go/β1/γ2	3.31	2025-11-26	10.1101/2025.05.26.656101
	9KXS (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-		3.31	2025-11-26	10.1101/2025.05.26.656101
	9UMR	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMR (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMX	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-	Go/β1/γ2	3.2	2025-11-26	10.1101/2025.05.26.656101
	9UMX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-		3.2	2025-11-26	10.1101/2025.05.26.656101
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.54	2025-01-15	To be published
	9KUG	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-	Go/β1/γ2	3.07	2025-11-26	10.1101/2025.05.26.656101
	9KUG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-		3.07	2025-11-26	10.1101/2025.05.26.656101

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HK5_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.