psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?0	L:L:F1	3.65	No	Yes	0	0	0
2	L:L:?0	R:R:D191	12.19	No	No	0	0	4
3	L:L:F1	R:R:R178	9.62	Yes	No	0	0	2
4	L:L:F1	R:R:L187	3.65	Yes	No	0	0	4
5	L:L:F1	R:R:G189	4.52	Yes	No	0	0	4
6	L:L:K2	L:L:L4	4.23	Yes	No	0	0	0
7	L:L:K2	R:R:E199	6.75	Yes	No	0	0	4
8	L:L:K2	R:R:F275	6.2	Yes	Yes	0	0	3
9	L:L:P3	R:R:K279	5.02	No	No	0	0	4
10	L:L:L4	L:L:R8	7.29	No	Yes	0	0	0
11	L:L:A5	R:R:H100	2.93	No	No	0	0	4
12	L:L:A6	R:R:L92	4.73	No	No	0	0	6
13	L:L:?7	L:L:R8	6.18	No	Yes	0	0	0
14	L:L:?7	R:R:I116	2.9	No	No	0	0	6
15	L:L:?7	R:R:L117	7.04	No	No	0	0	4
16	L:L:R8	R:R:Y258	13.38	Yes	Yes	0	0	7
17	L:L:R8	R:R:T261	3.88	Yes	No	0	0	4
18	L:L:R8	R:R:G262	6	Yes	No	0	0	5
19	L:L:R8	R:R:D282	9.53	Yes	Yes	0	0	4
20	R:R:P36	R:R:R34	7.21	Yes	No	0	3	2
21	R:R:D37	R:R:R34	3.57	No	No	0	4	2
22	R:R:K280	R:R:R34	11.14	No	No	0	2	2
23	R:R:P36	R:R:V35	3.53	Yes	No	0	3	3
24	R:R:L39	R:R:V35	2.98	No	No	0	5	3
25	R:R:L284	R:R:P36	6.57	No	Yes	0	4	3
26	R:R:L284	R:R:L39	2.77	No	No	0	4	5
27	R:R:A40	R:R:F44	2.77	No	Yes	3	6	7
28	R:R:A40	R:R:S283	3.42	No	No	3	6	4
29	R:R:F93	R:R:L41	6.09	No	No	0	7	5
30	R:R:I96	R:R:L41	4.28	No	No	0	5	5
31	R:R:I43	R:R:S287	10.84	No	No	0	5	4
32	R:R:F44	R:R:L89	2.44	Yes	Yes	3	7	7
33	R:R:F44	R:R:S283	2.64	Yes	No	3	7	4
34	R:R:F44	R:R:V286	3.93	Yes	No	3	7	5
35	R:R:F44	R:R:S287	6.61	Yes	No	0	7	4
36	R:R:F44	R:R:Y290	6.19	Yes	Yes	3	7	7
37	R:R:I291	R:R:V47	3.07	No	No	0	5	6
38	R:R:F48	R:R:V52	7.87	No	No	0	6	5
39	R:R:F48	R:R:L89	6.09	No	Yes	0	6	7
40	R:R:C294	R:R:V50	3.42	No	No	0	7	6
41	R:R:D82	R:R:N55	6.73	Yes	No	0	9	9
42	R:R:N55	R:R:P297	8.15	No	No	0	9	9
43	R:R:L57	R:R:V61	2.98	No	No	1	5	6
44	R:R:L311	R:R:L57	4.15	No	No	1	6	5
45	R:R:S314	R:R:W60	3.71	No	No	0	4	4
46	R:R:F307	R:R:V61	10.49	Yes	No	1	9	6
47	R:R:L311	R:R:V61	2.98	No	No	1	6	6
48	R:R:L76	R:R:T62	5.9	No	No	0	6	6
49	R:R:F64	R:R:R68	11.76	No	No	0	4	7
50	R:R:F64	R:R:S314	6.61	No	No	0	4	4
51	R:R:E65	R:R:R310	11.63	No	Yes	0	5	4
52	R:R:K67	R:R:R68	6.19	No	No	0	6	7
53	R:R:I70	R:R:R148	7.52	No	No	0	6	7
54	R:R:F75	R:R:N71	7.25	Yes	No	0	8	7
55	R:R:A153	R:R:I73	3.25	No	Yes	0	7	6
56	R:R:I73	R:R:W154	11.74	Yes	No	0	6	3
57	R:R:T129	R:R:W74	4.85	No	Yes	0	6	7
58	R:R:I130	R:R:W74	3.52	No	Yes	0	8	7
59	R:R:D133	R:R:W74	16.75	No	Yes	0	8	7
60	R:R:A153	R:R:W74	7.78	No	Yes	0	7	7
61	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
62	R:R:C157	R:R:W74	2.61	No	Yes	0	6	7
63	R:R:F75	R:R:I130	3.77	Yes	No	1	8	8
64	R:R:F75	R:R:R134	3.21	Yes	No	1	8	9
65	R:R:F75	R:R:Y300	13.41	Yes	No	1	8	9
66	R:R:L126	R:R:N77	2.75	No	No	0	7	9
67	R:R:C157	R:R:N77	9.45	No	No	0	6	9
68	R:R:N77	R:R:W161	3.39	No	No	0	9	9
69	R:R:D82	R:R:L78	4.07	Yes	Yes	6	9	9
70	R:R:L78	R:R:S123	3	Yes	No	6	9	9
71	R:R:L126	R:R:L78	4.15	No	Yes	0	7	9
72	R:R:L127	R:R:L78	2.77	No	Yes	0	8	9
73	R:R:A81	R:R:W161	2.59	No	No	0	8	9
74	R:R:D82	R:R:S123	4.42	Yes	No	6	9	9
75	R:R:D82	R:R:N296	2.69	Yes	No	0	9	9
76	R:R:F83	R:R:L87	7.31	No	No	0	8	4
77	R:R:L84	R:R:N119	5.49	No	No	0	6	9
78	R:R:N119	R:R:S85	5.96	No	No	0	9	6
79	R:R:A88	R:R:I116	3.25	No	No	0	6	6
80	R:R:L89	R:R:Y290	10.55	Yes	Yes	3	7	7
81	R:R:F104	R:R:I91	2.51	No	No	0	7	6
82	R:R:I91	R:R:L112	7.14	No	No	0	6	5
83	R:R:I96	R:R:S283	4.64	No	No	0	5	4
84	R:R:H101	R:R:Q98	4.95	No	No	0	4	4
85	R:R:P103	R:R:Q98	3.16	No	No	0	3	4
86	R:R:H101	R:R:V186	6.92	No	No	0	4	6
87	R:R:F104	R:R:W102	25.05	No	Yes	0	7	8
88	R:R:G105	R:R:W102	2.81	No	Yes	0	7	8
89	R:R:A108	R:R:W102	2.59	No	Yes	0	5	8
90	R:R:C109	R:R:W102	9.14	No	Yes	8	9	8
91	R:R:C188	R:R:W102	9.14	No	Yes	8	9	8
92	R:R:F104	R:R:P103	2.89	No	No	0	7	3
93	R:R:C109	R:R:V177	3.42	No	No	0	9	4
94	R:R:C109	R:R:C188	7.28	No	No	8	9	9
95	R:R:F172	R:R:I111	2.51	No	No	0	4	4
96	R:R:P113	R:R:R175	12.97	No	No	0	6	5
97	R:R:S114	R:R:S171	3.26	Yes	No	0	5	5
98	R:R:F172	R:R:S114	15.85	No	Yes	0	4	5
99	R:R:L117	R:R:Y121	10.55	No	No	0	4	7
100	R:R:L118	R:R:L165	2.77	No	No	0	5	4
101	R:R:L118	R:R:T168	7.37	No	No	0	5	6
102	R:R:M120	R:R:Y290	5.99	No	Yes	0	7	7
103	R:R:L167	R:R:Y121	8.21	No	No	0	4	7
104	R:R:R206	R:R:Y121	3.09	No	No	0	6	7
105	R:R:A122	R:R:W161	7.78	No	No	0	6	9
106	R:R:I124	R:R:P214	3.39	No	No	0	8	9
107	R:R:F251	R:R:I124	3.77	Yes	No	2	9	8
108	R:R:I124	R:R:W255	10.57	No	Yes	2	8	9
109	R:R:L127	R:R:N296	4.12	No	No	0	8	9
110	R:R:I130	R:R:R134	3.76	No	No	1	8	9
111	R:R:L218	R:R:S131	3	No	No	2	8	9
112	R:R:C221	R:R:S131	3.44	No	No	0	6	9
113	R:R:S131	R:R:Y222	7.63	No	Yes	2	9	8
114	R:R:D133	R:R:L137	8.14	No	No	0	8	8
115	R:R:F135	R:R:F139	6.43	Yes	No	0	8	7
116	R:R:C221	R:R:F135	9.78	No	Yes	0	6	8
117	R:R:F135	R:R:F224	5.36	Yes	No	0	8	3
118	R:R:F135	R:R:I225	3.77	Yes	No	0	8	8
119	R:R:C144	R:R:L137	3.17	Yes	No	7	5	8
120	R:R:L137	R:R:R148	6.07	No	No	7	8	7
121	R:R:F139	R:R:V138	3.93	No	No	0	7	8
122	R:R:I225	R:R:V138	4.61	No	No	0	8	8
123	R:R:F139	R:R:R228	16.03	No	No	0	7	5
124	R:R:C144	R:R:W143	3.92	Yes	No	0	5	5
125	R:R:F147	R:R:W143	4.01	No	No	0	4	5
126	R:R:C144	R:R:R148	4.18	Yes	No	7	5	7
127	R:R:F147	R:R:N146	7.25	No	No	0	4	5
128	R:R:L167	R:R:L209	5.54	No	No	0	4	4
129	R:R:I169	R:R:P170	5.08	No	No	0	3	8
130	R:R:P170	R:R:R206	2.88	No	No	0	8	6
131	R:R:R175	R:R:S171	5.27	No	No	0	5	5
132	R:R:L173	R:R:Y174	4.69	No	No	0	4	4
133	R:R:Y174	R:R:Y192	5.96	No	Yes	9	4	5
134	R:R:R198	R:R:Y174	8.23	No	No	9	3	4
135	R:R:R175	R:R:V190	2.62	No	No	0	5	5
136	R:R:E179	R:R:V186	7.13	No	No	0	2	6
137	R:R:E180	R:R:F182	9.33	No	No	0	1	3
138	R:R:E180	R:R:K185	14.85	No	No	0	1	3
139	R:R:F182	R:R:P183	2.89	No	No	0	3	4
140	R:R:K185	R:R:P183	3.35	No	No	0	3	4
141	R:R:V190	R:R:Y192	2.52	No	Yes	0	5	5
142	R:R:D191	R:R:S193	2.94	No	No	0	4	4
143	R:R:R198	R:R:Y192	4.12	No	Yes	9	3	5
144	R:R:E199	R:R:Y192	15.71	No	Yes	0	4	5
145	R:R:V202	R:R:Y192	3.79	No	Yes	0	5	5
146	R:R:D195	R:R:R198	7.15	No	No	0	3	3
147	R:R:K196	R:R:R200	6.19	No	No	0	2	3
148	R:R:E199	R:R:S266	2.87	No	No	0	4	5
149	R:R:R206	R:R:V202	7.85	No	No	0	6	5
150	R:R:A203	R:R:S266	3.42	No	No	0	5	5
151	R:R:F267	R:R:I204	2.51	No	No	0	4	3
152	R:R:L207	R:R:Q259	3.99	No	Yes	0	5	8
153	R:R:I263	R:R:L207	2.85	No	No	0	5	5
154	R:R:F211	R:R:L256	3.65	No	No	0	8	5
155	R:R:F211	R:R:Q259	9.37	No	Yes	0	8	8
156	R:R:P214	R:R:W213	5.4	No	No	0	9	5
157	R:R:T217	R:R:W213	4.85	No	No	0	5	5
158	R:R:L215	R:R:T219	2.95	No	No	0	5	4
159	R:R:F251	R:R:L215	3.65	Yes	No	0	9	5
160	R:R:F252	R:R:L215	4.87	No	No	0	5	5
161	R:R:L218	R:R:Y222	8.21	No	Yes	2	8	8
162	R:R:F251	R:R:L218	2.44	Yes	No	2	9	8
163	R:R:V244	R:R:Y222	13.88	No	Yes	0	7	8
164	R:R:V247	R:R:Y222	3.79	No	Yes	0	7	8
165	R:R:V248	R:R:Y222	2.52	No	Yes	0	7	8
166	R:R:L226	R:R:T240	4.42	Yes	No	0	5	7
167	R:R:L226	R:R:L241	4.15	Yes	No	0	5	6
168	R:R:L226	R:R:V244	4.47	Yes	No	0	5	7
169	R:R:T229	R:R:T235	3.14	No	No	0	8	4
170	R:R:K239	R:R:K242	2.87	No	No	0	7	6
171	R:R:L241	R:R:V245	2.98	No	No	0	6	4
172	R:R:F254	R:R:S250	3.96	Yes	No	4	8	6
173	R:R:I295	R:R:S250	3.1	No	No	4	7	6
174	R:R:F251	R:R:W255	4.01	Yes	Yes	2	9	9
175	R:R:F252	R:R:L256	3.65	No	No	0	5	5
176	R:R:F254	R:R:I253	2.51	Yes	No	0	8	5
177	R:R:F254	R:R:F288	9.65	Yes	No	0	8	8
178	R:R:F254	R:R:I291	6.28	Yes	No	4	8	5
179	R:R:F254	R:R:I295	5.02	Yes	No	4	8	7
180	R:R:W255	R:R:Y258	3.86	Yes	Yes	2	9	7
181	R:R:Q259	R:R:W255	4.38	Yes	Yes	2	8	9
182	R:R:N292	R:R:W255	7.91	No	Yes	0	9	9
183	R:R:L256	R:R:P257	3.28	No	No	0	5	9
184	R:R:F288	R:R:P257	4.33	No	No	0	8	9
185	R:R:Q259	R:R:Y258	5.64	Yes	Yes	2	8	7
186	R:R:A289	R:R:Y258	5.34	No	Yes	0	8	7
187	R:R:M264	R:R:V260	3.04	No	No	0	4	6
188	R:R:C285	R:R:T261	6.76	No	No	0	6	4
189	R:R:F267	R:R:I263	10.05	No	No	0	4	5
190	R:R:L278	R:R:M264	2.83	No	No	0	4	4
191	R:R:F275	R:R:M265	2.49	Yes	Yes	5	3	4
192	R:R:L278	R:R:M265	5.65	No	Yes	0	4	4
193	R:R:K279	R:R:M265	2.88	No	Yes	5	4	4
194	R:R:D282	R:R:M265	2.77	Yes	Yes	0	4	4
195	R:R:L268	R:R:T274	5.9	No	No	0	2	1
196	R:R:F275	R:R:L268	2.44	Yes	No	0	3	2
197	R:R:E269	R:R:P270	3.14	No	No	0	3	3
198	R:R:F275	R:R:K279	3.72	Yes	No	5	3	4
199	R:R:K280	R:R:L276	4.23	No	No	0	2	3
200	R:R:D282	R:R:V286	2.92	Yes	No	0	4	5
201	R:R:V286	R:R:Y290	2.52	No	Yes	3	5	7
202	R:R:I291	R:R:I295	7.36	No	No	4	5	7
203	R:R:N292	R:R:N296	10.9	No	No	0	9	9
204	R:R:F307	R:R:Y300	3.09	Yes	No	1	9	9
205	R:R:R310	R:R:Y300	7.2	Yes	No	1	4	9
206	R:R:F307	R:R:V301	11.8	Yes	No	0	9	6
207	R:R:F307	R:R:R310	4.28	Yes	Yes	1	9	4
208	R:R:Q308	R:R:R312	12.85	No	No	0	8	5
209	R:R:T229	R:R:W230	2.43	No	No	0	8	4
210	R:R:F83	R:R:N55	2.42	No	No	0	8	9
211	R:R:L92	R:R:Y290	2.34	No	Yes	0	6	7
212	R:R:L226	R:R:W230	2.28	Yes	No	0	5	4
213	R:R:E179	R:R:Y181	2.24	No	No	0	2	1
214	R:R:F267	R:R:R200	2.14	No	No	0	4	3
215	R:R:R233	R:R:R236	2.13	No	No	0	4	5
216	R:R:G105	R:R:G106	2.11	No	No	0	7	3
217	R:R:R236	R:R:W230	2	No	No	0	5	4
218	R:R:C86	R:R:G51	1.96	No	No	0	5	8
219	R:R:P183	R:R:P184	1.95	No	No	0	4	5
220	L:L:?0	R:R:H194	1.93	No	No	0	0	1
221	R:R:A128	R:R:P214	1.87	No	No	0	7	9
222	R:R:G51	R:R:V50	1.84	No	No	0	8	6
223	R:R:C293	R:R:C86	1.82	No	No	0	8	5
224	R:R:A122	R:R:A164	1.79	No	No	0	6	7
225	R:R:P273	R:R:S272	1.78	No	No	0	2	4
226	R:R:P297	R:R:V58	1.77	No	No	0	9	8
227	R:R:G149	R:R:I70	1.76	No	No	0	5	6
228	R:R:C293	R:R:S85	1.72	No	No	0	8	6
229	R:R:C294	R:R:V47	1.71	No	No	0	7	6
230	R:R:C86	R:R:V52	1.71	No	No	0	5	5
231	R:R:G54	R:R:L53	1.71	No	No	0	7	4
232	R:R:A79	R:R:V58	1.7	No	No	0	8	8
233	R:R:A79	R:R:V59	1.7	No	No	0	8	7
234	R:R:A303	R:R:V243	1.7	No	No	0	6	7
235	R:R:I142	R:R:P141	1.69	No	No	0	5	8
236	R:R:A72	R:R:T62	1.68	No	No	0	7	6
237	R:R:A72	R:R:T69	1.68	No	No	0	7	7
238	L:L:K2	R:R:P270	1.67	Yes	No	0	0	3
239	R:R:K140	R:R:P141	1.67	No	No	0	6	8
240	R:R:L281	R:R:P36	1.64	No	Yes	0	5	3
241	R:R:L89	R:R:P90	1.64	Yes	No	0	7	9
242	R:R:L112	R:R:P113	1.64	No	No	0	5	6
243	R:R:G309	R:R:Q308	1.64	No	No	0	5	8
244	R:R:A66	R:R:I73	1.62	No	Yes	0	5	6
245	R:R:A150	R:R:I73	1.62	No	Yes	0	3	6
246	R:R:A246	R:R:I299	1.62	No	No	0	5	7
247	R:R:A303	R:R:I299	1.62	No	No	0	6	7
248	R:R:V42	R:R:V46	1.6	No	No	0	5	4
249	R:R:V59	R:R:V80	1.6	No	No	0	7	5
250	R:R:S114	R:R:T168	1.6	Yes	No	0	5	6
251	R:R:V243	R:R:V247	1.6	No	No	0	7	7
252	R:R:S272	R:R:T274	1.6	No	No	0	4	1
253	R:R:T62	R:R:V58	1.59	No	No	0	6	8
254	R:R:C144	R:R:L136	1.59	Yes	No	0	5	5
255	R:R:A40	R:R:L284	1.58	No	No	0	6	4
256	R:R:A160	R:R:L125	1.58	No	No	0	6	6
257	R:R:A160	R:R:L126	1.58	No	No	0	6	7
258	L:L:A5	R:R:D282	1.54	No	Yes	0	0	4
259	R:R:I43	R:R:V42	1.54	No	No	0	5	5
260	R:R:I155	R:R:V159	1.54	No	No	0	2	1
261	R:R:I204	R:R:V208	1.54	No	No	0	3	4
262	R:R:I298	R:R:V302	1.54	No	No	0	7	6
263	R:R:K239	R:R:S237	1.53	No	No	0	7	7
264	R:R:K239	R:R:V243	1.52	No	No	0	7	7
265	R:R:L115	R:R:S114	1.5	No	Yes	0	5	5
266	R:R:G304	R:R:R310	1.5	No	Yes	0	8	4
267	R:R:L49	R:R:V50	1.49	No	No	0	4	6
268	R:R:L163	R:R:V159	1.49	No	No	0	4	1
269	R:R:L167	R:R:V205	1.49	No	No	0	4	3
270	R:R:D191	R:R:V176	1.46	No	No	0	4	4
271	R:R:G151	R:R:W154	1.41	No	No	0	4	3
272	R:R:A56	R:R:F83	1.39	No	No	0	3	8
273	R:R:H100	R:R:S95	1.39	No	No	0	4	4
274	R:R:L125	R:R:L163	1.38	No	No	0	6	4
275	R:R:L311	R:R:Q308	1.33	No	No	0	6	8
276	R:R:N146	R:R:Q145	1.32	No	No	0	5	5
277	R:R:R232	R:R:S231	1.32	No	No	0	5	4
278	R:R:A63	R:R:W60	1.3	No	No	0	3	4
279	R:R:F93	R:R:T94	1.3	No	No	0	7	3
280	R:R:F224	R:R:T223	1.3	No	No	0	3	2
281	R:R:R68	R:R:T69	1.29	No	No	0	7	7
282	R:R:H100	R:R:L187	1.29	No	No	0	4	4
283	R:R:R232	R:R:T235	1.29	No	No	0	5	4
284	R:R:F211	R:R:L212	1.22	No	No	0	8	4
285	R:R:D195	R:R:R197	1.19	No	No	0	3	1
286	R:R:K140	R:R:W143	1.16	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F1	5.36	4	0	0
2	L:L:K2	4.7125	4	0	0
3	L:L:R8	7.71	6	0	0
4	R:R:P36	4.7375	4	0	3
5	R:R:F44	4.09667	6	3	7
6	R:R:I73	4.5575	4	0	6
7	R:R:W74	6.35	6	0	7
8	R:R:F75	6.91	4	1	8
9	R:R:L78	3.4975	4	6	9
10	R:R:D82	4.4775	4	6	9
11	R:R:L89	5.18	4	3	7
12	R:R:W102	9.746	5	8	8
13	R:R:S114	5.5525	4	0	5
14	R:R:F135	6.335	4	0	8
15	R:R:C144	3.215	4	7	5
16	R:R:Y192	6.42	5	9	5
17	R:R:Y222	7.206	5	2	8
18	R:R:L226	3.83	4	0	5
19	R:R:F251	3.4675	4	2	9
20	R:R:F254	5.484	5	4	8
21	R:R:W255	6.146	5	2	9
22	R:R:Y258	7.055	4	2	7
23	R:R:Q259	5.845	4	2	8
24	R:R:M265	3.4475	4	5	4
25	R:R:F275	3.7125	4	5	3
26	R:R:D282	4.19	4	0	4
27	R:R:Y290	5.518	5	3	7
28	R:R:F307	7.415	4	1	9
29	R:R:R310	6.1525	4	1	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F1	R:R:L187	11.3704	3.65	Yes	No	0	0	4
2	R:R:H100	R:R:L187	12.7625	1.29	No	No	0	4	4
3	L:L:A5	R:R:H100	15.5151	2.93	No	No	0	0	4
4	L:L:A5	R:R:D282	16.7649	1.54	No	Yes	0	0	4
5	L:L:R8	R:R:D282	67.1465	9.53	Yes	Yes	0	0	4
6	L:L:L4	L:L:R8	46.8736	7.29	No	Yes	0	0	0
7	L:L:K2	L:L:L4	46.0787	4.23	Yes	No	0	0	0
8	R:R:D282	R:R:M265	22.0289	2.77	Yes	Yes	0	4	4
9	R:R:F275	R:R:M265	16.3931	2.49	Yes	Yes	5	3	4
10	L:L:K2	R:R:F275	16.2863	6.2	Yes	Yes	0	0	3
11	L:L:K2	R:R:E199	50.5596	6.75	Yes	No	0	0	4
12	R:R:D282	R:R:V286	58.9164	2.92	Yes	No	0	4	5
13	R:R:V286	R:R:Y290	18.4576	2.52	No	Yes	3	5	7
14	L:L:?7	L:L:R8	13.4665	6.18	No	Yes	0	0	0
15	L:L:?7	R:R:L117	10.1799	7.04	No	No	0	0	4
16	L:L:R8	R:R:Y258	99.1892	13.38	Yes	Yes	0	0	7
17	R:R:F44	R:R:V286	39.4344	3.93	Yes	No	3	7	5
18	R:R:A40	R:R:F44	14.8309	2.77	No	Yes	3	6	7
19	R:R:A40	R:R:L284	13.7196	1.58	No	No	0	6	4
20	R:R:F44	R:R:L89	15.2976	2.44	Yes	Yes	3	7	7
21	R:R:L89	R:R:Y290	13.9529	10.55	Yes	Yes	3	7	7
22	R:R:F211	R:R:Q259	13.7947	9.37	No	Yes	0	8	8
23	R:R:F211	R:R:L256	11.5246	3.65	No	No	0	8	5
24	R:R:L256	R:R:P257	12.0427	3.28	No	No	0	5	9
25	R:R:F288	R:R:P257	10.8997	4.33	No	No	0	8	9
26	R:R:F48	R:R:L89	24.3188	6.09	No	Yes	0	6	7
27	R:R:F48	R:R:V52	21.8509	7.87	No	No	0	6	5
28	R:R:C86	R:R:V52	19.3909	1.71	No	No	0	5	5
29	R:R:W255	R:R:Y258	89.8042	3.86	Yes	Yes	2	9	7
30	R:R:N292	R:R:W255	100	7.91	No	Yes	0	9	9
31	R:R:N292	R:R:N296	99.7152	10.9	No	No	0	9	9
32	R:R:D82	R:R:N296	57.7378	2.69	Yes	No	0	9	9
33	R:R:D82	R:R:N55	19.3079	6.73	Yes	No	0	9	9
34	R:R:N55	R:R:P297	15.4795	8.15	No	No	0	9	9
35	R:R:D82	R:R:L78	45.1572	4.07	Yes	Yes	6	9	9
36	R:R:L126	R:R:L78	84.9832	4.15	No	Yes	0	7	9
37	R:R:L126	R:R:N77	75.966	2.75	No	No	0	7	9
38	R:R:C157	R:R:N77	68.2341	9.45	No	No	0	6	9
39	R:R:C157	R:R:W74	66.664	2.61	No	Yes	0	6	7
40	R:R:I130	R:R:W74	28.5505	3.52	No	Yes	0	8	7
41	R:R:F75	R:R:I130	25.0662	3.77	Yes	No	1	8	8
42	R:R:F75	R:R:Y300	21.5385	13.41	Yes	No	1	8	9
43	R:R:F307	R:R:Y300	14.5897	3.09	Yes	No	1	9	9
44	R:R:F307	R:R:V61	11.0303	10.49	Yes	No	1	9	6
45	R:R:L127	R:R:N296	41.839	4.12	No	No	0	8	9
46	R:R:L127	R:R:L78	41.2537	2.77	No	Yes	0	8	9
47	R:R:P297	R:R:V58	14.5027	1.77	No	No	0	9	8
48	R:R:T62	R:R:V58	10.5161	1.59	No	No	0	6	8
49	R:R:D133	R:R:W74	25.3273	16.75	No	Yes	0	8	7
50	R:R:D133	R:R:L137	23.6623	8.14	No	No	0	8	8
51	R:R:A153	R:R:W74	11.1489	7.78	No	Yes	0	7	7
52	R:R:C293	R:R:C86	10.3896	1.82	No	No	0	8	5
53	R:R:E199	R:R:Y192	47.0239	15.71	No	Yes	0	4	5
54	R:R:V190	R:R:Y192	38.8689	2.52	No	Yes	0	5	5
55	R:R:R175	R:R:V190	37.5203	2.62	No	No	0	5	5
56	R:R:P113	R:R:R175	25.0188	12.97	No	No	0	6	5
57	R:R:L112	R:R:P113	23.7018	1.64	No	No	0	5	6
58	R:R:I91	R:R:L112	22.2622	7.14	No	No	0	6	5
59	R:R:F104	R:R:I91	20.9294	2.51	No	No	0	7	6
60	R:R:F104	R:R:W102	10.7099	25.05	No	Yes	0	7	8
61	R:R:R175	R:R:S171	12.2088	5.27	No	No	0	5	5
62	R:R:S114	R:R:S171	10.7099	3.26	Yes	No	0	5	5
63	R:R:F251	R:R:W255	39.557	4.01	Yes	Yes	2	9	9
64	R:R:F251	R:R:L218	38.2163	2.44	Yes	No	2	9	8
65	R:R:L218	R:R:S131	11.6235	3	No	No	2	8	9
66	R:R:C221	R:R:S131	11.2557	3.44	No	No	0	6	9
67	R:R:L218	R:R:Y222	25.5764	8.21	No	Yes	2	8	8
68	R:R:C221	R:R:F135	10.0257	9.78	No	Yes	0	6	8
69	R:R:C144	R:R:L137	16.5118	3.17	Yes	No	7	5	8
70	R:R:C144	R:R:W143	12.98	3.92	Yes	No	0	5	5
71	R:R:V244	R:R:Y222	14.8784	13.88	No	Yes	0	7	8
72	R:R:V247	R:R:Y222	10.0257	3.79	No	Yes	0	7	8
73	R:R:L226	R:R:V244	13.775	4.47	Yes	No	0	5	7
74	R:R:Q259	R:R:W255	13.0631	4.38	Yes	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?0	R:R:D191	12.19	0	No	No	0	4	0	1
L:L:F1	R:R:R178	9.62	0	Yes	No	0	2	0	1
L:L:F1	R:R:L187	3.65	0	Yes	No	0	4	0	1
L:L:F1	R:R:G189	4.52	0	Yes	No	0	4	0	1
L:L:K2	R:R:E199	6.75	0	Yes	No	0	4	0	1
L:L:K2	R:R:F275	6.2	0	Yes	Yes	0	3	0	1
L:L:P3	R:R:K279	5.02	0	No	No	0	4	0	1
L:L:A5	R:R:H100	2.93	0	No	No	0	4	0	1
L:L:A6	R:R:L92	4.73	0	No	No	0	6	0	1
L:L:?7	R:R:I116	2.9	0	No	No	0	6	0	1
L:L:?7	R:R:L117	7.04	0	No	No	0	4	0	1
L:L:R8	R:R:Y258	13.38	0	Yes	Yes	0	7	0	1
L:L:R8	R:R:T261	3.88	0	Yes	No	0	4	0	1
L:L:R8	R:R:G262	6	0	Yes	No	0	5	0	1
L:L:R8	R:R:D282	9.53	0	Yes	Yes	0	4	0	1
R:R:A88	R:R:I116	3.25	0	No	No	6	6	2	1
R:R:L117	R:R:Y121	10.55	0	No	No	4	7	1	2
R:R:D191	R:R:S193	2.94	0	No	No	4	4	1	2
R:R:E199	R:R:Y192	15.71	0	No	Yes	4	5	1	2
R:R:E199	R:R:S266	2.87	0	No	No	4	5	1	2
R:R:W255	R:R:Y258	3.86	2	Yes	Yes	9	7	2	1
R:R:Q259	R:R:W255	4.38	2	Yes	Yes	8	9	2	2
R:R:Q259	R:R:Y258	5.64	2	Yes	Yes	8	7	2	1
R:R:A289	R:R:Y258	5.34	0	No	Yes	8	7	2	1
R:R:C285	R:R:T261	6.76	0	No	No	6	4	2	1
R:R:F275	R:R:M265	2.49	5	Yes	Yes	3	4	1	2
R:R:K279	R:R:M265	2.88	5	No	Yes	4	4	1	2
R:R:D282	R:R:M265	2.77	0	Yes	Yes	4	4	1	2
R:R:F275	R:R:L268	2.44	5	Yes	No	3	2	1	2
R:R:E269	R:R:P270	3.14	0	No	No	3	3	2	1
R:R:F275	R:R:K279	3.72	5	Yes	No	3	4	1	1
R:R:D282	R:R:V286	2.92	0	Yes	No	4	5	1	2
R:R:V286	R:R:Y290	2.52	3	No	Yes	5	7	2	2
R:R:L92	R:R:Y290	2.34	0	No	Yes	6	7	1	2
L:L:?0	R:R:H194	1.93	0	No	No	0	1	0	1
L:L:K2	R:R:P270	1.67	0	Yes	No	0	3	0	1
L:L:A5	R:R:D282	1.54	0	No	Yes	0	4	0	1
R:R:D191	R:R:V176	1.46	0	No	No	4	4	1	2
R:R:H100	R:R:S95	1.39	0	No	No	4	4	1	2
R:R:H100	R:R:L187	1.29	0	No	No	4	4	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y66_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	266
Number of Links	286
Number of Hubs	29
Number of Links mediated by Hubs	114
Number of Communities	9
Number of Nodes involved in Communities	42
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	49827
Length Of Smallest Path	3
Average Path Length	15.3958
Length of Longest Path	35
Minimum Path Strength	1.305
Average Path Strength	5.61629
Maximum Path Strength	17.095
Minimum Path Correlation	0.7
Average Path Correlation	0.931659
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	50.8732
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.3438
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACE
PDB Residues	L:L:?0
Environment Details	Open EMBL-EBI Page
Code	ACE
Name	ACETYL GROUP
Synonyms
Identifier
Formula	C2 H4 O
Molecular Weight	44.053
SMILES
PubChem	177
Formal Charge	0
Total Atoms	7
Total Chiral Atoms	0
Total Bonds	6
Total Aromatic Bonds	0


Code	DAL
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>7Y66_nogp_Chain_R R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y66_nogp.zip

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