Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3G | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 | - | 2.5 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
![](/psngpcr/ligands/ACE/ACE_7M3G_W_W_1.png)
A 2D representation of the interactions of ACE in 7M3G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C482 | W:W:?2 | 11.81 | 2 | Yes | Yes | 7 | 0 | 2 | 1 | R:R:C482 | W:W:?3 | 3.23 | 2 | Yes | Yes | 7 | 0 | 2 | 1 | S:S:E251 | S:S:S247 | 4.31 | 2 | Yes | No | 4 | 2 | 1 | 2 | S:S:S247 | W:W:?5 | 4.8 | 2 | No | Yes | 2 | 0 | 2 | 2 | S:S:D248 | S:S:E250 | 9.09 | 2 | No | No | 3 | 2 | 1 | 2 | S:S:D248 | S:S:E251 | 14.29 | 2 | No | Yes | 3 | 4 | 1 | 1 | S:S:D248 | W:W:?1 | 6.11 | 2 | No | Yes | 3 | 0 | 1 | 0 | S:S:E251 | W:W:?1 | 5.97 | 2 | Yes | Yes | 4 | 0 | 1 | 0 | S:S:E251 | W:W:?4 | 7.42 | 2 | Yes | Yes | 4 | 0 | 1 | 2 | S:S:E251 | W:W:?5 | 10.59 | 2 | Yes | Yes | 4 | 0 | 1 | 2 | W:W:?1 | W:W:?2 | 23.2 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | W:W:?1 | W:W:?3 | 6.34 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | W:W:?2 | W:W:?3 | 20.97 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | W:W:?2 | W:W:?6 | 8.24 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | W:W:?3 | W:W:?4 | 19.14 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | W:W:?3 | W:W:?5 | 3.38 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | W:W:?3 | W:W:?6 | 14.64 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | W:W:?3 | W:W:?7 | 2.87 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | W:W:?4 | W:W:?5 | 14.15 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | W:W:?4 | W:W:?6 | 6.19 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | W:W:?4 | W:W:?7 | 7.88 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | W:W:?5 | W:W:?6 | 15.04 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | W:W:?5 | W:W:?7 | 7.88 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | W:W:?6 | W:W:?7 | 15.76 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 10.41 | Average Nodes In Shell | 12.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 24.00 | Average Links Mediated by Hubs In Shell | 23.00 |
| ![](/psngpcr/ligands/ACE/ACE_7M3G_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_7M3G_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/ACE/ACE_7M3G_X_X_1.png)
A 2D representation of the interactions of ACE in 7M3G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E251 | R:R:S247 | 4.31 | 1 | Yes | Yes | 4 | 2 | 1 | 2 | R:R:S247 | X:X:?5 | 7.2 | 1 | Yes | Yes | 2 | 0 | 2 | 2 | R:R:D248 | R:R:E250 | 11.69 | 1 | No | No | 3 | 2 | 1 | 2 | R:R:D248 | R:R:E251 | 16.89 | 1 | No | Yes | 3 | 4 | 1 | 1 | R:R:D248 | X:X:?1 | 6.11 | 1 | No | Yes | 3 | 0 | 1 | 0 | R:R:E251 | X:X:?1 | 5.97 | 1 | Yes | Yes | 4 | 0 | 1 | 0 | R:R:E251 | X:X:?4 | 6.36 | 1 | Yes | Yes | 4 | 0 | 1 | 1 | R:R:E251 | X:X:?5 | 12.71 | 1 | Yes | Yes | 4 | 0 | 1 | 2 | R:R:H254 | X:X:?4 | 7.19 | 1 | No | Yes | 3 | 0 | 2 | 1 | S:S:C482 | X:X:?2 | 11.81 | 1 | Yes | Yes | 7 | 0 | 2 | 1 | S:S:C482 | X:X:?3 | 4.84 | 1 | Yes | Yes | 7 | 0 | 2 | 1 | S:S:C482 | X:X:?6 | 3.81 | 1 | Yes | Yes | 7 | 0 | 2 | 2 | X:X:?1 | X:X:?2 | 27.06 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | X:X:?1 | X:X:?3 | 6.34 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | X:X:?1 | X:X:?4 | 6.64 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | X:X:?2 | X:X:?3 | 20.97 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | X:X:?2 | X:X:?4 | 5.15 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | X:X:?2 | X:X:?5 | 5.15 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?2 | X:X:?6 | 5.15 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?3 | X:X:?4 | 16.89 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | X:X:?3 | X:X:?6 | 16.89 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?3 | X:X:?7 | 2.87 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?4 | X:X:?5 | 15.92 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?4 | X:X:?6 | 6.19 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?4 | X:X:?7 | 5.63 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?4 | X:X:?8 | 4.42 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | X:X:?5 | X:X:?6 | 15.92 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | X:X:?5 | X:X:?7 | 7.88 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | X:X:?5 | X:X:?8 | 8.85 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | X:X:?6 | X:X:?7 | 19.14 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | X:X:?6 | X:X:?8 | 4.42 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | X:X:?7 | X:X:?8 | 20.26 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 10.42 | Average Nodes In Shell | 14.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/ACE/ACE_7M3G_X_X_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_7M3G_X_X_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XNA | A | Peptide | Somatostatin | SST2 | Homo sapiens | CYN154806 | - | - | 2.65 | 2022-08-03 | 10.1038/s41422-022-00679-x |
![](/psngpcr/ligands/ACE/ACE_7XNA_L_L_1.png)
A 2D representation of the interactions of ACE in 7XNA colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I209 | R:R:Y205 | 6.04 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:S279 | R:R:Y205 | 5.09 | 0 | No | Yes | 4 | 4 | 2 | 1 | L:L:?1 | R:R:Y205 | 12.32 | 1 | No | Yes | 0 | 4 | 0 | 1 | L:L:?2 | R:R:Y205 | 10.98 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | R:R:F275 | R:R:F294 | 13.93 | 1 | No | No | 4 | 4 | 2 | 2 | L:L:?2 | R:R:F275 | 9.5 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:?2 | R:R:M282 | 4.41 | 1 | Yes | No | 0 | 3 | 1 | 2 | L:L:?2 | R:R:P286 | 12.81 | 1 | Yes | No | 0 | 2 | 1 | 2 | L:L:?2 | R:R:L290 | 5.4 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:?2 | R:R:F294 | 11.41 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:?1 | L:L:?2 | 17.83 | 1 | No | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:?3 | 24.12 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?2 | L:L:C8 | 4.95 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?3 | L:L:C8 | 8.86 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | L:L:?1 | R:R:S201 | 2.25 | 1 | No | No | 0 | 2 | 0 | 1 | R:R:G202 | R:R:S201 | 1.86 | 0 | No | No | 2 | 2 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 10.80 | Average Nodes In Shell | 14.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 16.00 | Average Links Mediated by Hubs In Shell | 13.00 |
| ![](/psngpcr/ligands/ACE/ACE_7XNA_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_7XNA_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y66 | A | Peptide | Complement peptide | C5A1 | Homo Sapiens | BM213 | - | Gi1/Beta1/Gamma2 | 2.9 | 2023-03-01 | 10.1038/s41422-023-00779-2 |
![](/psngpcr/ligands/ACE/ACE_7Y66_L_L_0.png)
A 2D representation of the interactions of ACE in 7Y66 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:F1 | R:R:R178 | 9.62 | 0 | Yes | No | 0 | 2 | 1 | 2 | L:L:F1 | R:R:L187 | 3.65 | 0 | Yes | No | 0 | 4 | 1 | 2 | L:L:F1 | R:R:G189 | 4.52 | 0 | Yes | No | 0 | 4 | 1 | 2 | R:R:D191 | R:R:S193 | 2.94 | 0 | No | No | 4 | 4 | 1 | 2 | L:L:?0 | R:R:D191 | 12.22 | 0 | No | No | 0 | 4 | 0 | 1 | L:L:?0 | L:L:F1 | 3.66 | 0 | No | Yes | 0 | 0 | 0 | 1 | L:L:?0 | R:R:H194 | 1.93 | 0 | No | No | 0 | 1 | 0 | 1 | R:R:D191 | R:R:V176 | 1.46 | 0 | No | No | 4 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 5.94 | Average Nodes In Shell | 9.00 | Average Hubs In Shell | 1.00 | Average Links In Shell | 8.00 | Average Links Mediated by Hubs In Shell | 4.00 |
| ![](/psngpcr/ligands/ACE/ACE_7Y66_L_L_0_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_7Y66_L_L_0_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7ZBC | A | Sensory | Opsins | Rhodopsin | Bos Taurus | 11-cis-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
![](/psngpcr/ligands/ACE/ACE_7ZBC_H_H_401.png)
A 2D representation of the interactions of ACE in 7ZBC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M1 | R:R:Y10 | 4.79 | 0 | No | Yes | 6 | 7 | 1 | 2 | H:H:?401 | R:R:M1 | 6.37 | 6 | No | No | 0 | 6 | 0 | 1 | R:R:D282 | R:R:N2 | 14.81 | 6 | No | No | 2 | 6 | 2 | 1 | H:H:?401 | R:R:N2 | 10.3 | 6 | No | No | 0 | 6 | 0 | 1 | H:H:?403 | R:R:N2 | 24.5 | 6 | Yes | No | 0 | 6 | 1 | 1 | H:H:?403 | R:R:G280 | 4.58 | 6 | Yes | No | 0 | 1 | 1 | 2 | H:H:?403 | R:R:D282 | 6.05 | 6 | Yes | No | 0 | 2 | 1 | 2 | H:H:?401 | H:H:?403 | 27.79 | 6 | No | Yes | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 14.82 | Average Nodes In Shell | 7.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 8.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/ACE/ACE_7ZBC_H_H_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_7ZBC_H_H_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7ZBE | A | Sensory | Opsins | Rhodopsin | Bos Taurus | 11-cis-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
![](/psngpcr/ligands/ACE/ACE_7ZBE_H_H_401.png)
A 2D representation of the interactions of ACE in 7ZBE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M1 | R:R:Y10 | 4.79 | 0 | No | Yes | 6 | 7 | 1 | 2 | H:H:?401 | R:R:M1 | 6.37 | 4 | No | No | 0 | 6 | 0 | 1 | R:R:D282 | R:R:N2 | 14.81 | 4 | No | No | 2 | 6 | 2 | 1 | H:H:?401 | R:R:N2 | 10.3 | 4 | No | No | 0 | 6 | 0 | 1 | H:H:?403 | R:R:N2 | 24.5 | 4 | Yes | No | 0 | 6 | 1 | 1 | H:H:?403 | R:R:D282 | 6.05 | 4 | Yes | No | 0 | 2 | 1 | 2 | H:H:?401 | H:H:?403 | 25.94 | 4 | No | Yes | 0 | 0 | 0 | 1 | H:H:?403 | R:R:G280 | 3.05 | 4 | Yes | No | 0 | 1 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 14.20 | Average Nodes In Shell | 7.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 8.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/ACE/ACE_7ZBE_H_H_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_7ZBE_H_H_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8A6C | A | Sensory | Opsins | Rhodopsin | Bos Taurus | All-trans-retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
![](/psngpcr/ligands/ACE/ACE_8A6C_H_H_401.png)
A 2D representation of the interactions of ACE in 8A6C colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M1 | R:R:Y10 | 4.79 | 0 | No | Yes | 6 | 7 | 1 | 2 | H:H:?401 | R:R:M1 | 6.37 | 3 | No | No | 0 | 6 | 0 | 1 | R:R:D282 | R:R:N2 | 13.46 | 3 | No | No | 2 | 6 | 2 | 1 | H:H:?401 | R:R:N2 | 8.24 | 3 | No | No | 0 | 6 | 0 | 1 | H:H:?403 | R:R:N2 | 23.27 | 3 | Yes | No | 0 | 6 | 1 | 1 | H:H:?403 | R:R:G280 | 3.05 | 3 | Yes | No | 0 | 1 | 1 | 2 | H:H:?403 | R:R:D282 | 6.05 | 3 | Yes | No | 0 | 2 | 1 | 2 | H:H:?401 | H:H:?403 | 25.94 | 3 | No | Yes | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 13.52 | Average Nodes In Shell | 7.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 8.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/ACE/ACE_8A6C_H_H_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_8A6C_H_H_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8A6D | A | Sensory | Opsins | Rhodopsin | Bos Taurus | All-trans-retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
![](/psngpcr/ligands/ACE/ACE_8A6D_H_H_401.png)
A 2D representation of the interactions of ACE in 8A6D colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:G280 | R:R:M1 | 3.49 | 0 | No | No | 1 | 6 | 2 | 1 | H:H:?401 | R:R:M1 | 6.37 | 4 | No | No | 0 | 6 | 0 | 1 | R:R:D282 | R:R:N2 | 8.08 | 4 | No | No | 2 | 6 | 2 | 1 | H:H:?401 | R:R:N2 | 4.12 | 4 | No | No | 0 | 6 | 0 | 1 | H:H:?403 | R:R:N2 | 24.5 | 4 | Yes | No | 0 | 6 | 1 | 1 | H:H:?403 | R:R:G280 | 4.58 | 4 | Yes | No | 0 | 1 | 1 | 2 | H:H:?403 | R:R:D282 | 8.47 | 4 | Yes | No | 0 | 2 | 1 | 2 | H:H:?401 | H:H:?403 | 16.68 | 4 | No | Yes | 0 | 0 | 0 | 1 | R:R:E5 | R:R:M1 | 2.71 | 0 | No | No | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 9.06 | Average Nodes In Shell | 7.00 | Average Hubs In Shell | 1.00 | Average Links In Shell | 9.00 | Average Links Mediated by Hubs In Shell | 4.00 |
| ![](/psngpcr/ligands/ACE/ACE_8A6D_H_H_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_8A6D_H_H_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8A6E | A | Sensory | Opsins | Rhodopsin | Bos Taurus | All-trans-retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
![](/psngpcr/ligands/ACE/ACE_8A6E_H_H_401.png)
A 2D representation of the interactions of ACE in 8A6E colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E5 | R:R:M1 | 4.06 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:M1 | R:R:Y10 | 5.99 | 0 | No | No | 6 | 7 | 1 | 2 | H:H:?401 | R:R:M1 | 6.37 | 6 | No | No | 0 | 6 | 0 | 1 | R:R:D282 | R:R:N2 | 10.77 | 6 | No | No | 2 | 6 | 2 | 1 | H:H:?401 | R:R:N2 | 4.12 | 6 | No | No | 0 | 6 | 0 | 1 | H:H:?403 | R:R:N2 | 24.5 | 6 | Yes | No | 0 | 6 | 1 | 1 | H:H:?403 | R:R:G280 | 4.58 | 6 | Yes | No | 0 | 1 | 1 | 2 | H:H:?403 | R:R:D282 | 9.68 | 6 | Yes | No | 0 | 2 | 1 | 2 | H:H:?401 | H:H:?403 | 16.68 | 6 | No | Yes | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 9.06 | Average Nodes In Shell | 8.00 | Average Hubs In Shell | 1.00 | Average Links In Shell | 9.00 | Average Links Mediated by Hubs In Shell | 4.00 |
| ![](/psngpcr/ligands/ACE/ACE_8A6E_H_H_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_8A6E_H_H_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FEG | A | Peptide | Opioid | KOP | Homo Sapiens | PRD_002517 | - | Gi1/Beta1/Gamma2 | 2.54 | 2023-12-06 | 10.1038/s41467-023-43718-w |
![](/psngpcr/ligands/ACE/ACE_8FEG_L_L_1.png)
A 2D representation of the interactions of ACE in 8FEG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E209 | R:R:R202 | 13.96 | 1 | Yes | Yes | 3 | 2 | 2 | 2 | L:L:?4 | R:R:R202 | 4.86 | 1 | Yes | Yes | 0 | 2 | 2 | 2 | L:L:?5 | R:R:R202 | 3.38 | 1 | Yes | Yes | 0 | 2 | 1 | 2 | L:L:?5 | R:R:E209 | 3.69 | 1 | Yes | Yes | 0 | 3 | 1 | 2 | L:L:T6 | R:R:E209 | 5.64 | 1 | No | Yes | 0 | 3 | 2 | 2 | R:R:E297 | R:R:F293 | 15.16 | 1 | No | No | 5 | 5 | 2 | 2 | R:R:F293 | R:R:Y312 | 8.25 | 1 | No | Yes | 5 | 4 | 2 | 1 | L:L:Y2 | R:R:F293 | 4.13 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:Y2 | R:R:E297 | 13.47 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:A308 | R:R:S303 | 3.42 | 1 | No | No | 3 | 1 | 2 | 2 | L:L:Y2 | R:R:S303 | 6.36 | 1 | Yes | No | 0 | 1 | 1 | 2 | L:L:Y2 | R:R:S305 | 7.63 | 1 | Yes | No | 0 | 3 | 1 | 2 | L:L:?4 | R:R:S305 | 6.01 | 1 | Yes | No | 0 | 3 | 2 | 2 | L:L:Y2 | R:R:A308 | 9.34 | 1 | Yes | No | 0 | 3 | 1 | 2 | R:R:L309 | R:R:Y313 | 7.03 | 1 | No | No | 4 | 4 | 1 | 2 | L:L:?1 | R:R:L309 | 14.54 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:Y2 | R:R:L309 | 7.03 | 1 | Yes | No | 0 | 4 | 1 | 1 | R:R:I316 | R:R:Y312 | 7.25 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:Y312 | 12.32 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?10 | R:R:Y312 | 3.89 | 1 | Yes | Yes | 0 | 4 | 2 | 1 | L:L:?10 | R:R:I316 | 7.1 | 1 | Yes | Yes | 0 | 5 | 2 | 2 | L:L:?1 | L:L:Y2 | 12.32 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?1 | L:L:?5 | 5.78 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?1 | L:L:C7 | 11.91 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:A3 | L:L:Y2 | 8.01 | 1 | No | Yes | 0 | 0 | 2 | 1 | L:L:?4 | L:L:Y2 | 14.08 | 1 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?4 | L:L:A3 | 10.09 | 1 | Yes | No | 0 | 0 | 2 | 2 | L:L:?4 | L:L:?5 | 23.66 | 1 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?5 | L:L:T6 | 10.94 | 1 | Yes | No | 0 | 0 | 1 | 2 | L:L:?5 | L:L:C7 | 8.84 | 1 | Yes | No | 0 | 0 | 1 | 1 | L:L:?5 | R:R:N122 | 1.27 | 1 | Yes | No | 0 | 5 | 1 | 2 | |
Statistics | Value |
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Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 11.37 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| ![](/psngpcr/ligands/ACE/ACE_8FEG_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_8FEG_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IOD | A | Peptide | Melanocortin | MC5 | Homo Sapiens | PG-901 | Ca | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.59 | 2023-09-20 | 10.1038/s41421-023-00586-4 |
![](/psngpcr/ligands/ACE/ACE_8IOD_L_L_0.png)
A 2D representation of the interactions of ACE in 8IOD colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?0 | L:L:?1 | 21.6 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?0 | R:R:V111 | 4.47 | 5 | Yes | No | 0 | 3 | 0 | 1 | L:L:?0 | R:R:D115 | 16.29 | 5 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:T95 | 5.57 | 5 | Yes | No | 0 | 4 | 1 | 2 | L:L:?1 | R:R:I96 | 14.84 | 5 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?1 | R:R:V111 | 4.23 | 5 | Yes | No | 0 | 3 | 1 | 1 | L:L:?1 | R:R:D115 | 16.68 | 5 | Yes | Yes | 0 | 8 | 1 | 1 | R:R:E92 | R:R:I96 | 4.1 | 5 | Yes | Yes | 6 | 4 | 2 | 2 | R:R:D115 | R:R:E92 | 3.9 | 5 | Yes | Yes | 8 | 6 | 1 | 2 | R:R:D119 | R:R:E92 | 9.09 | 5 | Yes | Yes | 4 | 6 | 2 | 2 | I:I:?1 | R:R:E92 | 7.3 | 5 | Yes | Yes | 0 | 6 | 2 | 2 | R:R:L99 | R:R:V111 | 4.47 | 0 | No | No | 2 | 3 | 2 | 1 | R:R:D115 | R:R:D119 | 11.98 | 5 | Yes | Yes | 8 | 4 | 1 | 2 | I:I:?1 | R:R:D115 | 7.48 | 5 | Yes | Yes | 0 | 8 | 2 | 1 | I:I:?1 | R:R:D119 | 7.48 | 5 | Yes | Yes | 0 | 4 | 2 | 2 | R:R:A109 | R:R:R112 | 2.77 | 0 | No | No | 2 | 3 | 2 | 1 | L:L:?0 | R:R:R112 | 1.82 | 5 | Yes | No | 0 | 3 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 11.04 | Average Nodes In Shell | 12.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 17.00 | Average Links Mediated by Hubs In Shell | 15.00 |
| ![](/psngpcr/ligands/ACE/ACE_8IOD_L_L_0_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ACE/ACE_8IOD_L_L_0_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|