| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3G | C | Ion | Calcium Sensing | CaS | Homo Sapiens | - | Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 | - | 2.5 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
|
A 2D representation of the interactions of ACE in 7M3G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:C482 | W:W:?2 | 11.86 | 2 | Yes | Yes | 7 | 0 | 2 | 1 | | R:R:C482 | W:W:?3 | 3.22 | 2 | Yes | Yes | 7 | 0 | 2 | 1 | | S:S:E251 | S:S:S247 | 4.31 | 2 | Yes | No | 4 | 2 | 1 | 2 | | S:S:S247 | W:W:?5 | 4.79 | 2 | No | Yes | 2 | 0 | 2 | 2 | | S:S:D248 | S:S:E250 | 9.09 | 2 | No | No | 3 | 2 | 1 | 2 | | S:S:D248 | S:S:E251 | 14.29 | 2 | No | Yes | 3 | 4 | 1 | 1 | | S:S:D248 | W:W:?1 | 6.11 | 2 | No | Yes | 3 | 0 | 1 | 0 | | S:S:E251 | W:W:?1 | 5.97 | 2 | Yes | Yes | 4 | 0 | 1 | 0 | | S:S:E251 | W:W:?4 | 7.4 | 2 | Yes | Yes | 4 | 0 | 1 | 2 | | S:S:E251 | W:W:?5 | 10.57 | 2 | Yes | Yes | 4 | 0 | 1 | 2 | | W:W:?1 | W:W:?2 | 23.28 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | | W:W:?1 | W:W:?3 | 6.32 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | | W:W:?2 | W:W:?3 | 20.99 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | | W:W:?2 | W:W:?6 | 8.25 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | W:W:?3 | W:W:?4 | 19.04 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | W:W:?3 | W:W:?5 | 3.36 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | W:W:?3 | W:W:?6 | 14.56 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | W:W:?3 | W:W:?7 | 2.85 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | W:W:?4 | W:W:?5 | 14.08 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | | W:W:?4 | W:W:?6 | 6.16 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | | W:W:?4 | W:W:?7 | 7.84 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | | W:W:?5 | W:W:?6 | 14.96 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | | W:W:?5 | W:W:?7 | 7.84 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | | W:W:?6 | W:W:?7 | 15.68 | 2 | Yes | Yes | 0 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 10.42 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 24.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of ACE in 7M3G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E251 | R:R:S247 | 4.31 | 1 | Yes | Yes | 4 | 2 | 1 | 2 | | R:R:S247 | X:X:?5 | 7.18 | 1 | Yes | Yes | 2 | 0 | 2 | 2 | | R:R:D248 | R:R:E250 | 11.69 | 1 | No | No | 3 | 2 | 1 | 2 | | R:R:D248 | R:R:E251 | 16.89 | 1 | No | Yes | 3 | 4 | 1 | 1 | | R:R:D248 | X:X:?1 | 6.11 | 1 | No | Yes | 3 | 0 | 1 | 0 | | R:R:E251 | X:X:?1 | 5.97 | 1 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:E251 | X:X:?4 | 6.34 | 1 | Yes | Yes | 4 | 0 | 1 | 1 | | R:R:E251 | X:X:?5 | 12.68 | 1 | Yes | Yes | 4 | 0 | 1 | 2 | | R:R:H254 | X:X:?4 | 7.18 | 1 | No | Yes | 3 | 0 | 2 | 1 | | S:S:C482 | X:X:?2 | 11.86 | 1 | Yes | Yes | 7 | 0 | 2 | 1 | | S:S:C482 | X:X:?3 | 4.83 | 1 | Yes | Yes | 7 | 0 | 2 | 1 | | S:S:C482 | X:X:?6 | 3.8 | 1 | Yes | Yes | 7 | 0 | 2 | 2 | | X:X:?1 | X:X:?2 | 27.17 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | | X:X:?1 | X:X:?3 | 6.32 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | | X:X:?1 | X:X:?4 | 6.63 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | | X:X:?2 | X:X:?3 | 20.99 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | | X:X:?2 | X:X:?4 | 5.16 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | | X:X:?2 | X:X:?5 | 5.16 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?2 | X:X:?6 | 5.16 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?3 | X:X:?4 | 16.8 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | | X:X:?3 | X:X:?6 | 16.8 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?3 | X:X:?7 | 2.85 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?4 | X:X:?5 | 15.84 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?4 | X:X:?6 | 6.16 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?4 | X:X:?7 | 5.6 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?4 | X:X:?8 | 4.4 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | X:X:?5 | X:X:?6 | 15.84 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | | X:X:?5 | X:X:?7 | 7.84 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | | X:X:?5 | X:X:?8 | 8.8 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | | X:X:?6 | X:X:?7 | 19.04 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | | X:X:?6 | X:X:?8 | 4.4 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | | X:X:?7 | X:X:?8 | 20.16 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 10.44 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 11.00 | | Average Links In Shell | 32.00 | | Average Links Mediated by Hubs In Shell | 31.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XNA | A | Peptide | Somatostatin | SST2 | Homo Sapiens | CYN154806 | - | - | 2.65 | 2022-08-03 | 10.1038/s41422-022-00679-x |
|
A 2D representation of the interactions of ACE in 7XNA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | L:L:?2 | 17.78 | 1 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | R:R:Y205 | 12.31 | 1 | No | Yes | 0 | 4 | 0 | 1 | | L:L:?2 | L:L:?3 | 24.15 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:?2 | L:L:C8 | 4.94 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:?2 | R:R:Y205 | 10.95 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | | L:L:?2 | R:R:F275 | 9.48 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?2 | R:R:M282 | 4.4 | 1 | Yes | No | 0 | 3 | 1 | 2 | | L:L:?2 | R:R:P286 | 12.78 | 1 | Yes | No | 0 | 2 | 1 | 2 | | L:L:?2 | R:R:L290 | 5.39 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?2 | R:R:F294 | 11.38 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?3 | L:L:C8 | 8.9 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | | R:R:I209 | R:R:Y205 | 6.04 | 0 | No | Yes | 5 | 4 | 2 | 1 | | R:R:S279 | R:R:Y205 | 5.09 | 0 | No | Yes | 4 | 4 | 2 | 1 | | R:R:F275 | R:R:F294 | 13.93 | 1 | No | No | 4 | 4 | 2 | 2 | | R:R:G202 | R:R:Y205 | 1.45 | 0 | No | Yes | 2 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 15.05 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y66 | A | Peptide | Complement Peptide | C5A1 | Homo Sapiens | BM213 | - | Gi1/Beta1/Gamma2 | 2.9 | 2023-03-01 | 10.1038/s41422-023-00779-2 |
|
A 2D representation of the interactions of ACE in 7Y66
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?0 | L:L:F1 | 3.65 | 0 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?0 | R:R:D191 | 12.19 | 0 | No | No | 0 | 4 | 0 | 1 | | L:L:F1 | R:R:R178 | 9.62 | 0 | Yes | No | 0 | 2 | 1 | 2 | | L:L:F1 | R:R:L187 | 3.65 | 0 | Yes | No | 0 | 4 | 1 | 2 | | L:L:F1 | R:R:G189 | 4.52 | 0 | Yes | No | 0 | 4 | 1 | 2 | | R:R:D191 | R:R:S193 | 2.94 | 0 | No | No | 4 | 4 | 1 | 2 | | L:L:?0 | R:R:H194 | 1.93 | 0 | No | No | 0 | 1 | 0 | 1 | | R:R:D191 | R:R:V176 | 1.46 | 0 | No | No | 4 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.92 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7ZBC | A | Sensory | Opsins | Rhodopsin | Bos Taurus | 11-cis-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
|
A 2D representation of the interactions of ACE in 7ZBC
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | H:H:?401 | H:H:?403 | 27.9 | 5 | No | Yes | 0 | 0 | 0 | 1 | | H:H:?401 | R:R:M1 | 6.35 | 5 | No | No | 0 | 6 | 0 | 1 | | H:H:?401 | R:R:N2 | 10.28 | 5 | No | No | 0 | 6 | 0 | 1 | | H:H:?403 | R:R:N2 | 24.64 | 5 | Yes | No | 0 | 6 | 1 | 1 | | H:H:?403 | R:R:G280 | 4.6 | 5 | Yes | No | 0 | 1 | 1 | 2 | | H:H:?403 | R:R:D282 | 6.09 | 5 | Yes | No | 0 | 2 | 1 | 2 | | R:R:D282 | R:R:N2 | 14.81 | 5 | No | No | 2 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 14.84 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7ZBE | A | Sensory | Opsins | Rhodopsin | Bos Taurus | 11-cis-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
|
A 2D representation of the interactions of ACE in 7ZBE
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | H:H:?401 | H:H:?403 | 26.04 | 4 | No | Yes | 0 | 0 | 0 | 1 | | H:H:?401 | R:R:M1 | 6.35 | 4 | No | No | 0 | 6 | 0 | 1 | | H:H:?401 | R:R:N2 | 10.28 | 4 | No | No | 0 | 6 | 0 | 1 | | H:H:?403 | R:R:N2 | 24.64 | 4 | Yes | No | 0 | 6 | 1 | 1 | | H:H:?403 | R:R:D282 | 6.09 | 4 | Yes | No | 0 | 2 | 1 | 2 | | R:R:D282 | R:R:N2 | 14.81 | 4 | No | No | 2 | 6 | 2 | 1 | | H:H:?403 | R:R:G280 | 3.07 | 4 | Yes | No | 0 | 1 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 14.22 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8A6C | A | Sensory | Opsins | Rhodopsin | Bos Taurus | All-trans-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
|
A 2D representation of the interactions of ACE in 8A6C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | H:H:?401 | H:H:?403 | 26.04 | 3 | No | Yes | 0 | 0 | 0 | 1 | | H:H:?401 | R:R:M1 | 6.35 | 3 | No | No | 0 | 6 | 0 | 1 | | H:H:?401 | R:R:N2 | 8.23 | 3 | No | No | 0 | 6 | 0 | 1 | | H:H:?403 | R:R:N2 | 23.41 | 3 | Yes | No | 0 | 6 | 1 | 1 | | H:H:?403 | R:R:G280 | 3.07 | 3 | Yes | No | 0 | 1 | 1 | 2 | | H:H:?403 | R:R:D282 | 6.09 | 3 | Yes | No | 0 | 2 | 1 | 2 | | R:R:D282 | R:R:N2 | 13.46 | 3 | No | No | 2 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 13.54 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8A6D | A | Sensory | Opsins | Rhodopsin | Bos Taurus | All-trans-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
|
A 2D representation of the interactions of ACE in 8A6D
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | H:H:?401 | H:H:?403 | 16.74 | 3 | No | Yes | 0 | 0 | 0 | 1 | | H:H:?401 | R:R:M1 | 6.35 | 3 | No | No | 0 | 6 | 0 | 1 | | H:H:?401 | R:R:N2 | 4.11 | 3 | No | No | 0 | 6 | 0 | 1 | | H:H:?403 | R:R:N2 | 24.64 | 3 | Yes | No | 0 | 6 | 1 | 1 | | H:H:?403 | R:R:G280 | 4.6 | 3 | Yes | No | 0 | 1 | 1 | 2 | | H:H:?403 | R:R:D282 | 8.52 | 3 | Yes | No | 0 | 2 | 1 | 2 | | R:R:E5 | R:R:M1 | 4.06 | 0 | No | No | 6 | 6 | 2 | 1 | | R:R:M1 | R:R:Y10 | 3.59 | 0 | No | No | 6 | 7 | 1 | 2 | | R:R:D282 | R:R:N2 | 8.08 | 3 | No | No | 2 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 9.07 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8A6E | A | Sensory | Opsins | Rhodopsin | Bos Taurus | All-trans-Retinal | - | - | 1.8 | 2023-03-29 | 10.1038/s41586-023-05863-6 |
|
A 2D representation of the interactions of ACE in 8A6E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | H:H:?401 | H:H:?403 | 16.74 | 6 | No | Yes | 0 | 0 | 0 | 1 | | H:H:?401 | R:R:M1 | 4.23 | 6 | No | No | 0 | 6 | 0 | 1 | | H:H:?401 | R:R:N2 | 4.11 | 6 | No | No | 0 | 6 | 0 | 1 | | H:H:?403 | R:R:N2 | 24.64 | 6 | Yes | No | 0 | 6 | 1 | 1 | | H:H:?403 | R:R:G280 | 4.6 | 6 | Yes | No | 0 | 1 | 1 | 2 | | H:H:?403 | R:R:D282 | 9.74 | 6 | Yes | No | 0 | 2 | 1 | 2 | | R:R:D282 | R:R:N2 | 10.77 | 6 | No | No | 2 | 6 | 2 | 1 | | R:R:M1 | R:R:Y10 | 3.59 | 0 | No | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 8.36 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FEG | A | Peptide | Opioid | KOP | Homo Sapiens | (DNCP)-Beta-Naloxamine | - | Gi1/Beta1/Gamma2 | 2.54 | 2023-12-06 | 10.1038/s41467-023-43718-w |
|
A 2D representation of the interactions of ACE in 8FEG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | L:L:Y2 | 12.29 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:?5 | 5.74 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:C7 | 11.88 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | R:R:L309 | 14.51 | 3 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:Y312 | 12.29 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:A3 | L:L:Y2 | 8.01 | 3 | No | Yes | 0 | 0 | 2 | 1 | | L:L:?4 | L:L:Y2 | 14.06 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | | L:L:Y2 | R:R:F293 | 5.16 | 3 | Yes | No | 0 | 5 | 1 | 2 | | L:L:Y2 | R:R:E297 | 15.71 | 3 | Yes | No | 0 | 5 | 1 | 2 | | L:L:Y2 | R:R:S303 | 7.63 | 3 | Yes | No | 0 | 1 | 1 | 2 | | L:L:Y2 | R:R:S305 | 7.63 | 3 | Yes | No | 0 | 3 | 1 | 2 | | L:L:Y2 | R:R:L309 | 5.86 | 3 | Yes | No | 0 | 4 | 1 | 1 | | L:L:?4 | L:L:A3 | 10.08 | 3 | Yes | No | 0 | 0 | 2 | 2 | | L:L:?4 | L:L:?5 | 23.5 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | | L:L:?4 | R:R:R202 | 21.37 | 3 | Yes | No | 0 | 2 | 2 | 2 | | L:L:?4 | R:R:S305 | 6 | 3 | Yes | No | 0 | 3 | 2 | 2 | | L:L:?5 | L:L:T6 | 10.89 | 3 | Yes | No | 0 | 0 | 1 | 2 | | L:L:?5 | L:L:C7 | 8.79 | 3 | Yes | Yes | 0 | 0 | 1 | 1 | | L:L:?5 | R:R:R202 | 15.7 | 3 | Yes | No | 0 | 2 | 1 | 2 | | L:L:?5 | R:R:E209 | 4.89 | 3 | Yes | Yes | 0 | 3 | 1 | 2 | | L:L:T6 | R:R:E209 | 7.06 | 3 | No | Yes | 0 | 3 | 2 | 2 | | L:L:?9 | L:L:C7 | 2.69 | 3 | Yes | Yes | 0 | 0 | 2 | 1 | | L:L:C7 | R:R:Y312 | 5.38 | 3 | Yes | Yes | 0 | 4 | 1 | 1 | | R:R:Y119 | R:R:Y312 | 2.98 | 3 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:Y119 | R:R:Y313 | 39.71 | 3 | Yes | Yes | 4 | 4 | 2 | 2 | | R:R:I316 | R:R:Y119 | 8.46 | 3 | Yes | Yes | 5 | 4 | 2 | 2 | | R:R:E297 | R:R:F293 | 13.99 | 3 | No | No | 5 | 5 | 2 | 2 | | R:R:F293 | R:R:Y312 | 9.28 | 3 | No | Yes | 5 | 4 | 2 | 1 | | R:R:L309 | R:R:Y313 | 7.03 | 3 | No | Yes | 4 | 4 | 1 | 2 | | R:R:Y312 | R:R:Y313 | 4.96 | 3 | Yes | Yes | 4 | 4 | 1 | 2 | | R:R:I316 | R:R:Y312 | 9.67 | 3 | Yes | Yes | 5 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 11.34 | | Average Nodes In Shell | 19.00 | | Average Hubs In Shell | 11.00 | | Average Links In Shell | 31.00 | | Average Links Mediated by Hubs In Shell | 30.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IOD | A | Peptide | Melanocortin | MC5 | Homo Sapiens | PG-901 | Ca | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.59 | 2023-09-20 | 10.1038/s41421-023-00586-4 |
|
A 2D representation of the interactions of ACE in 8IOD
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?0 | L:L:?1 | 21.38 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:?0 | R:R:V111 | 4.46 | 4 | Yes | No | 0 | 3 | 0 | 1 | | L:L:?0 | R:R:D115 | 16.26 | 4 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | L:L:D2 | 8.91 | 4 | Yes | No | 0 | 0 | 1 | 2 | | L:L:?1 | R:R:T95 | 5.53 | 4 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?1 | R:R:I96 | 14.72 | 4 | Yes | Yes | 0 | 4 | 1 | 2 | | L:L:?1 | R:R:V111 | 4.19 | 4 | Yes | No | 0 | 3 | 1 | 1 | | L:L:?1 | R:R:D115 | 16.54 | 4 | Yes | Yes | 0 | 8 | 1 | 1 | | R:R:E92 | R:R:I96 | 4.1 | 4 | Yes | Yes | 6 | 4 | 2 | 2 | | R:R:D115 | R:R:E92 | 3.9 | 4 | Yes | Yes | 8 | 6 | 1 | 2 | | R:R:D119 | R:R:E92 | 9.09 | 4 | Yes | Yes | 4 | 6 | 2 | 2 | | I:I:?1 | R:R:E92 | 7.31 | 4 | Yes | Yes | 0 | 6 | 2 | 2 | | R:R:L99 | R:R:V111 | 4.47 | 0 | No | No | 2 | 3 | 2 | 1 | | R:R:D115 | R:R:D119 | 11.98 | 4 | Yes | Yes | 8 | 4 | 1 | 2 | | I:I:?1 | R:R:D115 | 7.49 | 4 | Yes | Yes | 0 | 8 | 2 | 1 | | I:I:?1 | R:R:D119 | 7.49 | 4 | Yes | Yes | 0 | 4 | 2 | 2 | | R:R:A109 | R:R:R112 | 2.77 | 0 | No | No | 2 | 3 | 2 | 1 | | L:L:?0 | R:R:R112 | 1.82 | 4 | Yes | No | 0 | 3 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 10.98 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8KIG | A | Peptide | Melanocortin | MC3 | Homo Sapiens | SHU9119 | Ca | - | 3.1 | 2025-02-26 | 10.2210/pdb8KIG/pdb |
|
A 2D representation of the interactions of ACE in 8KIG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?0 | L:L:?1 | 29.16 | 1 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?0 | L:L:D2 | 4.06 | 1 | No | No | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:D2 | 14 | 1 | Yes | No | 0 | 0 | 1 | 1 | | L:L:?1 | R:R:I98 | 5.35 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?1 | R:R:I113 | 6.69 | 1 | Yes | No | 0 | 8 | 1 | 2 | | L:L:?1 | R:R:D117 | 15.27 | 1 | Yes | Yes | 0 | 3 | 1 | 2 | | L:L:D2 | L:L:K7 | 11.06 | 1 | No | No | 0 | 0 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 16.61 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WKY | A | Peptide | Melanocortin | MC4 | Homo sapiens | PG-934 | - | - | 2.9 | 2024-08-07 | doi.org/10.1021/acs.jmedchem.3c01822 |
|
A 2D representation of the interactions of ACE in 8WKY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | L:L:?2 | 25.27 | 1 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:K9 | 10.56 | 1 | No | No | 0 | 0 | 0 | 1 | | L:L:?1 | R:R:D122 | 6.1 | 1 | No | Yes | 0 | 8 | 0 | 1 | | L:L:?2 | R:R:I104 | 9.37 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?2 | R:R:D122 | 12.73 | 1 | Yes | Yes | 0 | 8 | 1 | 1 | | L:L:D3 | L:L:K9 | 9.68 | 0 | No | No | 0 | 0 | 2 | 1 | | L:L:R6 | R:R:D122 | 4.76 | 1 | Yes | Yes | 0 | 8 | 2 | 1 | | L:L:R6 | R:R:D126 | 17.87 | 1 | Yes | Yes | 0 | 4 | 2 | 2 | | R:R:D122 | R:R:D126 | 9.31 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | | L:L:?2 | R:R:T118 | 2.76 | 1 | Yes | No | 0 | 6 | 1 | 2 | | L:L:?2 | R:R:I121 | 2.68 | 1 | Yes | No | 0 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.98 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WKZ | A | Peptide | Melanocortin | MC4 | Homo sapiens | SBL-MC-31 | - | - | 3.3 | 2024-08-07 | doi.org/10.1021/acs.jmedchem.3c01822 |
|
A 2D representation of the interactions of ACE in 8WKZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | L:L:?2 | 19.44 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:K9 | 12.67 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | R:R:V119 | 4.46 | 1 | Yes | No | 0 | 3 | 0 | 1 | | L:L:?1 | R:R:D122 | 12.19 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?2 | L:L:D3 | 7.64 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:?2 | L:L:K9 | 5.29 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | | L:L:?2 | R:R:I104 | 12.05 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | | L:L:?2 | R:R:L107 | 3.89 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?2 | R:R:D122 | 12.73 | 1 | Yes | Yes | 0 | 8 | 1 | 1 | | L:L:D3 | L:L:K9 | 9.68 | 1 | Yes | Yes | 0 | 0 | 2 | 1 | | L:L:R6 | R:R:D122 | 4.76 | 1 | Yes | Yes | 0 | 8 | 2 | 1 | | L:L:R6 | R:R:D126 | 17.87 | 1 | Yes | Yes | 0 | 4 | 2 | 2 | | L:L:?10 | L:L:K9 | 6.98 | 0 | No | Yes | 0 | 0 | 2 | 1 | | R:R:D122 | R:R:D126 | 10.65 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 12.19 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8XGO | A | Peptide | Kisspeptin | Kiss1 | Homo Sapiens | TAK448 | - | chim(NtGi1-Gq)/Beta1/Gamma2 | 2.68 | 2024-10-30 | doi.org/10.1126/sciadv.adn7771 |
|
A 2D representation of the interactions of ACE in 8XGO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D41 | R:R:Y299 | 4.6 | 3 | No | No | 2 | 4 | 2 | 2 | | R:R:D41 | R:R:Y302 | 6.9 | 3 | No | Yes | 2 | 5 | 2 | 1 | | R:R:Y103 | R:R:Y302 | 7.94 | 3 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:T306 | R:R:Y103 | 4.99 | 3 | No | Yes | 4 | 5 | 2 | 2 | | R:R:Y299 | R:R:Y302 | 4.96 | 3 | No | Yes | 4 | 5 | 2 | 1 | | R:R:T306 | R:R:Y302 | 6.24 | 3 | No | Yes | 4 | 5 | 2 | 1 | | L:L:?1 | R:R:Y302 | 7.02 | 0 | No | Yes | 0 | 5 | 0 | 1 | | L:L:Y2 | R:R:Y302 | 3.97 | 0 | No | Yes | 0 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 7.02 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8XGU | A | Peptide | Kisspeptin | Kiss1 | Homo Sapiens | TAK448 | - | Gi1/Beta1/Gamma2 | 3 | 2024-10-30 | doi.org/10.1126/sciadv.adn7771 |
|
A 2D representation of the interactions of ACE in 8XGU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | L:L:?2 | 19.89 | 6 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:?3 | 9.72 | 6 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?1 | L:L:T5 | 4.41 | 6 | No | Yes | 0 | 0 | 0 | 1 | | L:L:?2 | L:L:?3 | 20.76 | 6 | Yes | Yes | 0 | 0 | 1 | 1 | | L:L:?2 | L:L:T5 | 3.54 | 6 | Yes | Yes | 0 | 0 | 1 | 1 | | L:L:?2 | R:R:Y299 | 7.5 | 6 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?2 | R:R:Y302 | 2.81 | 6 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:?3 | L:L:N4 | 5.15 | 6 | Yes | No | 0 | 0 | 1 | 2 | | L:L:?3 | L:L:T5 | 2.76 | 6 | Yes | Yes | 0 | 0 | 1 | 1 | | L:L:?3 | R:R:Y190 | 11 | 6 | Yes | Yes | 0 | 4 | 1 | 2 | | L:L:N4 | R:R:Y190 | 11.63 | 6 | No | Yes | 0 | 4 | 2 | 2 | | L:L:F6 | L:L:T5 | 9.08 | 6 | Yes | Yes | 0 | 0 | 2 | 1 | | L:L:T5 | R:R:Y302 | 7.49 | 6 | Yes | Yes | 0 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 11.34 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
