psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N31	R:R:T32	4.39	No	No	0	1	4
2	R:R:D37	R:R:L33	4.07	No	No	0	4	4
3	R:R:H99	R:R:L33	7.71	No	No	0	2	4
4	R:R:K280	R:R:R34	11.14	No	No	0	2	2
5	R:R:P36	R:R:V35	3.53	Yes	No	0	3	3
6	R:R:L39	R:R:V35	2.98	No	No	0	5	3
7	R:R:D37	R:R:P36	3.22	No	Yes	0	4	3
8	R:R:L281	R:R:P36	3.28	No	Yes	0	5	3
9	R:R:L284	R:R:P36	3.28	No	Yes	0	4	3
10	R:R:D37	R:R:H100	5.04	No	No	0	4	4
11	R:R:A40	R:R:S287	3.42	No	Yes	0	6	4
12	R:R:F93	R:R:L41	12.18	No	No	1	7	5
13	R:R:I96	R:R:L41	4.28	Yes	No	1	5	5
14	R:R:L41	R:R:V97	2.98	No	No	1	5	3
15	R:R:I43	R:R:S287	12.39	No	Yes	0	5	4
16	R:R:F44	R:R:L89	8.53	Yes	Yes	1	7	7
17	R:R:F44	R:R:I96	3.77	Yes	Yes	1	7	5
18	R:R:F44	R:R:V286	3.93	Yes	No	0	7	5
19	R:R:F44	R:R:S287	5.28	Yes	Yes	0	7	4
20	R:R:F44	R:R:Y290	7.22	Yes	Yes	1	7	7
21	R:R:L89	R:R:V47	2.98	Yes	No	0	7	6
22	R:R:C294	R:R:V47	6.83	No	No	0	7	6
23	R:R:F48	R:R:V52	5.24	Yes	No	0	6	5
24	R:R:F48	R:R:L89	4.87	Yes	Yes	0	6	7
25	R:R:F48	R:R:P90	7.22	Yes	No	0	6	9
26	R:R:C294	R:R:V50	3.42	No	No	0	7	6
27	R:R:I298	R:R:V50	3.07	No	No	0	7	6
28	R:R:F83	R:R:V52	5.24	No	No	0	8	5
29	R:R:G54	R:R:P297	4.06	No	No	0	7	9
30	R:R:A79	R:R:N55	3.13	No	No	0	8	9
31	R:R:D82	R:R:N55	5.39	Yes	No	0	9	9
32	R:R:N55	R:R:P297	6.52	No	No	0	9	9
33	R:R:A79	R:R:V58	3.39	No	No	0	8	8
34	R:R:V58	R:R:Y300	3.79	No	Yes	4	8	9
35	R:R:L323	R:R:V58	4.47	Yes	No	4	5	8
36	R:R:L76	R:R:V59	4.47	No	No	0	6	7
37	R:R:F64	R:R:W60	14.03	No	No	0	4	4
38	R:R:L319	R:R:V61	4.47	No	No	0	5	6
39	R:R:R320	R:R:V61	6.54	No	No	0	6	6
40	R:R:A72	R:R:T62	3.36	No	No	0	7	6
41	R:R:L76	R:R:T62	5.9	No	No	0	6	6
42	R:R:E65	R:R:T324	14.11	No	No	0	5	5
43	R:R:I70	R:R:W74	8.22	Yes	Yes	2	6	7
44	R:R:I70	R:R:R148	13.78	Yes	Yes	2	6	7
45	R:R:A153	R:R:I70	3.25	No	Yes	2	7	6
46	R:R:N71	R:R:R134	3.62	Yes	Yes	2	7	9
47	R:R:N71	R:R:R148	4.82	Yes	Yes	2	7	7
48	R:R:N71	R:R:T240	5.85	Yes	No	2	7	7
49	R:R:N71	R:R:S327	5.96	Yes	Yes	2	7	4
50	R:R:I73	R:R:W154	21.14	No	No	0	6	3
51	R:R:T129	R:R:W74	4.85	No	Yes	0	6	7
52	R:R:I130	R:R:W74	12.92	No	Yes	0	8	7
53	R:R:D133	R:R:W74	11.17	No	Yes	2	8	7
54	R:R:A153	R:R:W74	3.89	No	Yes	2	7	7
55	R:R:F75	R:R:Y300	7.22	No	Yes	4	8	9
56	R:R:F75	R:R:L323	15.83	No	Yes	4	8	5
57	R:R:L126	R:R:N77	6.87	Yes	Yes	6	7	9
58	R:R:N77	R:R:W154	5.65	Yes	No	0	9	3
59	R:R:C157	R:R:N77	11.02	No	Yes	6	6	9
60	R:R:N77	R:R:W161	5.65	Yes	Yes	0	9	9
61	R:R:L126	R:R:L78	4.15	Yes	No	0	7	9
62	R:R:L127	R:R:L78	4.15	No	No	0	8	9
63	R:R:L84	R:R:V80	2.98	No	No	0	6	5
64	R:R:V80	R:R:W161	3.68	No	Yes	0	5	9
65	R:R:D82	R:R:N119	6.73	Yes	Yes	1	9	9
66	R:R:C293	R:R:D82	6.22	No	Yes	1	8	9
67	R:R:D82	R:R:N296	6.73	Yes	No	0	9	9
68	R:R:F83	R:R:L87	4.87	No	No	0	8	4
69	R:R:A85	R:R:N119	4.69	No	Yes	0	6	9
70	R:R:A85	R:R:Y290	4	No	Yes	0	6	7
71	R:R:A88	R:R:L112	4.73	No	No	0	6	5
72	R:R:A88	R:R:L115	4.73	No	No	0	6	5
73	R:R:L89	R:R:Y290	11.72	Yes	Yes	1	7	7
74	R:R:A91	R:R:F104	5.55	No	No	0	6	7
75	R:R:L92	R:R:Y290	3.52	No	Yes	0	6	7
76	R:R:F93	R:R:V97	3.93	No	No	1	7	3
77	R:R:S95	R:R:W102	4.94	No	Yes	0	4	8
78	R:R:H100	R:R:I96	3.98	No	Yes	1	4	5
79	R:R:I96	R:R:S283	4.64	Yes	No	1	5	4
80	R:R:H101	R:R:Q98	6.18	Yes	No	8	4	4
81	R:R:P103	R:R:Q98	3.16	No	No	8	3	4
82	R:R:H100	R:R:S283	5.58	No	No	1	4	4
83	R:R:H101	R:R:P103	6.1	Yes	No	8	4	3
84	R:R:H101	R:R:K185	5.24	Yes	No	0	4	3
85	R:R:H101	R:R:V186	5.54	Yes	No	0	4	6
86	R:R:F104	R:R:W102	18.04	No	Yes	0	7	8
87	R:R:C109	R:R:W102	3.92	No	Yes	7	9	8
88	R:R:C188	R:R:W102	5.22	No	Yes	7	9	8
89	R:R:F104	R:R:P103	13	No	No	0	7	3
90	R:R:A108	R:R:L112	3.15	No	No	0	5	5
91	R:R:C109	R:R:V177	3.42	No	No	0	9	4
92	R:R:C109	R:R:C188	7.28	No	No	7	9	9
93	R:R:P113	R:R:R175	8.65	No	No	0	6	5
94	R:R:L117	R:R:S114	3	No	No	0	4	5
95	R:R:A172	R:R:S114	3.42	No	No	0	4	5
96	R:R:I116	R:R:N119	4.25	No	Yes	0	6	9
97	R:R:I116	R:R:Y290	18.13	No	Yes	0	6	7
98	R:R:L117	R:R:S171	3	No	No	0	4	5
99	R:R:L118	R:R:L165	4.15	No	No	0	5	4
100	R:R:L118	R:R:T168	8.84	No	No	0	5	6
101	R:R:N119	R:R:S123	4.47	Yes	No	0	9	9
102	R:R:C293	R:R:N119	4.72	No	Yes	1	8	9
103	R:R:M120	R:R:Y121	8.38	No	No	0	7	7
104	R:R:M120	R:R:W255	16.29	No	Yes	0	7	9
105	R:R:L167	R:R:Y121	12.89	No	No	0	4	7
106	R:R:A122	R:R:W161	3.89	No	Yes	0	6	9
107	R:R:I124	R:R:P214	5.08	No	No	0	8	9
108	R:R:F251	R:R:I124	15.07	No	No	0	9	8
109	R:R:L125	R:R:L163	5.54	No	No	3	6	4
110	R:R:L125	W:W:?1	8.24	No	Yes	3	6	0
111	R:R:C157	R:R:L126	3.17	No	Yes	6	6	7
112	R:R:A160	R:R:L126	3.15	No	Yes	0	6	7
113	R:R:L127	R:R:V247	2.98	No	Yes	0	8	7
114	R:R:L127	R:R:V248	4.47	No	No	0	8	7
115	R:R:A128	W:W:?1	9.38	No	Yes	0	7	0
116	R:R:T129	W:W:?1	5.85	No	Yes	0	6	0
117	R:R:I130	R:R:V244	3.07	No	No	0	8	7
118	R:R:L218	R:R:S131	3	No	No	0	8	9
119	R:R:S131	R:R:Y222	8.9	No	Yes	0	9	8
120	R:R:D133	R:R:L137	5.43	No	Yes	2	8	8
121	R:R:D133	R:R:R148	16.68	No	Yes	2	8	7
122	R:R:L137	R:R:R134	6.07	Yes	Yes	2	8	9
123	R:R:R134	R:R:T238	3.88	Yes	No	0	9	5
124	R:R:R134	R:R:T240	7.76	Yes	No	2	9	7
125	R:R:L241	R:R:R134	4.86	No	Yes	0	6	9
126	R:R:R134	R:R:S327	5.27	Yes	Yes	2	9	4
127	R:R:F135	R:R:F139	16.08	No	Yes	0	8	7
128	R:R:F135	R:R:I225	5.02	No	No	0	8	8
129	R:R:L136	R:R:W143	3.42	No	No	0	5	5
130	R:R:C144	R:R:L137	6.35	No	Yes	0	5	8
131	R:R:L137	R:R:R148	7.29	Yes	Yes	2	8	7
132	R:R:L137	R:R:S327	6.01	Yes	Yes	2	8	4
133	R:R:F139	R:R:V138	10.49	Yes	No	0	7	8
134	R:R:F139	R:R:R228	11.76	Yes	No	0	7	5
135	R:R:F147	R:R:W143	20.04	No	No	0	4	5
136	R:R:Q145	R:R:V328	4.3	No	No	0	5	4
137	R:R:F147	R:R:R146	9.62	No	No	0	4	5
138	R:R:R148	R:R:S327	7.91	Yes	Yes	2	7	4
139	R:R:L152	R:R:L156	4.15	No	No	0	3	5
140	R:R:L156	W:W:?1	3.66	No	Yes	0	5	0
141	R:R:V159	W:W:?1	9.86	No	Yes	0	1	0
142	R:R:L163	W:W:?1	3.66	No	Yes	3	4	0
143	R:R:I169	R:R:P170	3.39	No	No	0	3	8
144	R:R:D191	R:R:Y174	3.45	No	No	0	4	4
145	R:R:C188	R:R:R175	4.18	No	No	0	9	5
146	R:R:G189	R:R:R175	3	No	No	0	4	5
147	R:R:E179	R:R:Y181	12.35	No	No	0	2	1
148	R:R:E180	R:R:L187	5.3	No	No	0	1	4
149	R:R:F182	R:R:Y181	6.19	No	No	0	3	1
150	R:R:E199	R:R:H194	14.77	No	No	0	4	1
151	R:R:D195	R:R:R197	4.76	No	No	0	3	1
152	R:R:D195	R:R:R198	7.15	No	No	0	3	3
153	R:R:F267	R:R:R200	16.03	No	No	0	4	3
154	R:R:R206	R:R:V202	6.54	No	No	0	6	5
155	R:R:A203	R:R:S266	3.42	No	No	0	5	5
156	R:R:F267	R:R:I204	5.02	No	No	0	4	3
157	R:R:L209	R:R:V205	2.98	No	No	0	4	3
158	R:R:L207	R:R:L212	6.92	No	No	0	5	4
159	R:R:L207	R:R:Q259	6.65	No	No	0	5	8
160	R:R:I263	R:R:L207	5.71	No	No	0	5	5
161	R:R:L209	W:W:?1	3.66	No	Yes	0	4	0
162	R:R:F211	R:R:L212	3.65	Yes	No	0	8	4
163	R:R:F211	R:R:F252	6.43	Yes	No	0	8	5
164	R:R:F211	R:R:L256	6.09	Yes	No	0	8	5
165	R:R:F211	R:R:Q259	5.86	Yes	No	0	8	8
166	R:R:P214	R:R:W213	4.05	No	No	3	9	5
167	R:R:T217	R:R:W213	10.92	No	No	3	5	5
168	R:R:W213	W:W:?1	19.59	No	Yes	3	5	0
169	R:R:P214	W:W:?1	5.43	No	Yes	3	9	0
170	R:R:F252	R:R:L215	14.61	No	No	0	5	5
171	R:R:I220	R:R:L216	4.28	No	No	0	3	2
172	R:R:T217	W:W:?1	4.88	No	Yes	3	5	0
173	R:R:L218	R:R:V248	2.98	No	No	0	8	7
174	R:R:C221	R:R:Y222	4.03	No	Yes	0	6	8
175	R:R:I225	R:R:Y222	3.63	No	Yes	0	8	8
176	R:R:V244	R:R:Y222	3.79	No	Yes	0	7	8
177	R:R:V245	R:R:Y222	3.79	No	Yes	0	4	8
178	R:R:R228	R:R:T235	3.88	No	No	0	5	4
179	R:R:T229	R:R:T235	3.14	No	No	0	8	4
180	R:R:S237	R:R:T229	3.2	No	No	0	7	8
181	R:R:S231	R:R:W230	3.71	No	No	0	4	4
182	R:R:A232	R:R:T235	3.36	No	No	0	5	4
183	R:R:L241	R:R:S237	4.5	No	No	0	6	7
184	R:R:K242	R:R:S237	6.12	No	No	0	6	7
185	R:R:E325	R:R:T238	9.88	No	No	0	8	5
186	R:R:F307	R:R:K239	21.09	No	No	0	9	7
187	R:R:E325	R:R:K239	4.05	No	No	0	8	7
188	R:R:E325	R:R:T240	9.88	No	No	0	8	7
189	R:R:L241	R:R:V245	2.98	No	No	0	6	4
190	R:R:A246	R:R:I299	3.25	No	Yes	0	5	7
191	R:R:S250	R:R:V247	3.23	Yes	Yes	5	6	7
192	R:R:N296	R:R:V247	8.87	No	Yes	0	9	7
193	R:R:I299	R:R:V247	3.07	Yes	Yes	5	7	7
194	R:R:N292	R:R:S250	2.98	No	Yes	0	9	6
195	R:R:I295	R:R:S250	4.64	No	Yes	5	7	6
196	R:R:I299	R:R:S250	3.1	Yes	Yes	5	7	6
197	R:R:F251	R:R:F252	8.57	No	No	0	9	5
198	R:R:F251	R:R:W255	10.02	No	Yes	0	9	9
199	R:R:F254	R:R:I253	3.77	Yes	No	0	8	5
200	R:R:F254	R:R:F288	12.86	Yes	No	0	8	8
201	R:R:F254	R:R:I291	20.09	Yes	No	0	8	5
202	R:R:F254	R:R:N292	8.46	Yes	No	0	8	9
203	R:R:F254	R:R:I295	7.54	Yes	No	0	8	7
204	R:R:W255	R:R:Y258	7.72	Yes	No	0	9	7
205	R:R:A289	R:R:W255	7.78	No	Yes	0	8	9
206	R:R:N292	R:R:W255	7.91	No	Yes	0	9	9
207	R:R:L256	R:R:P257	3.28	No	No	0	5	9
208	R:R:L256	R:R:V260	2.98	No	No	0	5	6
209	R:R:F288	R:R:P257	7.22	No	No	0	8	9
210	R:R:M264	R:R:V260	4.56	No	No	0	4	6
211	R:R:C285	R:R:T261	6.76	No	No	0	6	4
212	R:R:F267	R:R:I263	5.02	No	No	0	4	5
213	R:R:L278	R:R:M264	5.65	No	No	0	4	4
214	R:R:F275	R:R:M265	4.98	Yes	No	0	3	4
215	R:R:L278	R:R:M265	5.65	No	No	0	4	4
216	R:R:L268	R:R:T274	4.42	No	No	0	2	1
217	R:R:F275	R:R:L268	3.65	Yes	No	0	3	2
218	R:R:E269	R:R:P270	3.14	No	No	0	3	3
219	R:R:E269	R:R:S271	4.31	No	No	0	3	4
220	R:R:F275	R:R:P270	5.78	Yes	No	0	3	3
221	R:R:P273	R:R:S272	3.56	No	No	0	2	4
222	R:R:S272	R:R:T274	4.8	No	No	0	4	1
223	R:R:K280	R:R:L276	7.05	No	No	0	2	3
224	R:R:L277	R:R:L281	4.15	No	No	0	1	5
225	R:R:D282	R:R:V286	4.38	No	No	0	4	5
226	R:R:L284	R:R:S287	4.5	No	Yes	0	4	4
227	R:R:C293	R:R:Y290	4.03	No	Yes	1	8	7
228	R:R:I295	R:R:I299	7.36	No	Yes	5	7	7
229	R:R:N296	R:R:Y300	9.3	No	Yes	0	9	9
230	R:R:L323	R:R:Y300	14.07	Yes	Yes	4	5	9
231	R:R:L315	R:R:V301	2.98	No	No	0	6	6
232	R:R:G304	R:R:L318	5.13	No	No	0	8	3
233	R:R:E317	R:R:K313	5.4	No	No	0	3	4
234	R:R:P316	R:R:S314	5.34	No	No	0	5	4
235	R:R:E317	R:R:S314	5.75	No	No	0	3	4
236	R:R:L315	R:R:P316	3.28	No	No	0	6	5
237	R:R:L323	R:R:V322	5.96	Yes	No	0	5	5
238	R:R:R330	R:R:V328	7.85	No	No	0	5	4
239	R:R:L323	R:R:T62	2.95	Yes	No	0	5	6
240	R:R:L215	R:R:T219	2.95	No	No	0	5	4
241	R:R:L227	R:R:T223	2.95	No	No	0	4	2
242	R:R:L278	R:R:T261	2.95	No	No	0	4	4
243	R:R:Q305	R:R:V301	2.87	No	No	0	6	6
244	R:R:I111	R:R:L115	2.85	No	No	0	4	5
245	R:R:I169	R:R:L173	2.85	No	No	0	3	4
246	R:R:Q98	R:R:T94	2.83	No	No	0	4	3
247	R:R:E65	R:R:T69	2.82	No	No	0	5	7
248	R:R:K140	R:R:L136	2.82	No	No	0	6	5
249	R:R:K185	R:R:L187	2.82	No	No	0	3	4
250	R:R:G105	R:R:W102	2.81	No	Yes	0	7	8
251	R:R:A56	R:R:F83	2.77	No	No	0	3	8
252	R:R:L315	R:R:L57	2.77	No	No	0	6	5
253	R:R:L319	R:R:L57	2.77	No	No	0	5	5
254	R:R:A303	R:R:F307	2.77	No	No	0	6	9
255	R:R:E321	R:R:K239	2.7	No	No	0	6	7
256	R:R:E321	R:R:K313	2.7	No	No	0	6	4
257	R:R:F75	R:R:V243	2.62	No	No	0	8	7
258	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
259	R:R:A108	R:R:W102	2.59	No	Yes	0	5	8
260	R:R:F224	R:R:I220	2.51	No	No	0	3	3
261	R:R:F48	R:R:L49	2.44	Yes	No	0	6	4
262	R:R:L92	R:R:W102	2.28	No	Yes	0	6	8
263	R:R:F139	R:R:F224	2.14	Yes	No	0	7	3
264	R:R:G105	R:R:G106	2.11	No	No	0	7	3
265	R:R:C86	R:R:G51	1.96	No	No	0	5	8
266	R:R:C294	R:R:G51	1.96	No	No	0	7	8
267	R:R:A150	R:R:G151	1.95	No	No	0	3	4
268	R:R:P183	R:R:P184	1.95	No	No	0	4	5
269	R:R:A303	R:R:G304	1.95	No	No	0	6	8
270	R:R:G262	R:R:T261	1.82	No	No	0	5	4
271	R:R:A122	R:R:A164	1.79	No	No	0	6	7
272	R:R:G149	R:R:I70	1.76	No	Yes	0	5	6
273	R:R:G210	R:R:M120	1.75	No	No	0	6	7
274	R:R:G54	R:R:L53	1.71	No	No	0	7	4
275	R:R:A72	R:R:T69	1.68	No	No	0	7	7
276	R:R:A72	R:R:T324	1.68	No	No	0	7	5
277	R:R:K140	R:R:P141	1.67	No	No	0	6	8
278	R:R:G306	R:R:Q305	1.64	No	No	0	7	6
279	R:R:A66	R:R:I73	1.62	No	No	0	5	6
280	R:R:A150	R:R:I73	1.62	No	No	0	3	6
281	R:R:A203	R:R:I263	1.62	No	No	0	5	5
282	R:R:V42	R:R:V46	1.6	No	No	0	5	4
283	R:R:V46	R:R:V50	1.6	No	No	0	4	6
284	R:R:S114	R:R:T168	1.6	No	No	0	5	6
285	R:R:C144	R:R:L136	1.59	No	No	0	5	5
286	R:R:A63	R:R:L76	1.58	No	No	0	3	6
287	R:R:A164	R:R:L118	1.58	No	No	0	7	5
288	R:R:T219	R:R:T223	1.57	No	No	0	4	2
289	R:R:I155	R:R:V159	1.54	No	No	0	2	1
290	R:R:I204	R:R:V208	1.54	No	No	0	3	4
291	R:R:I298	R:R:V302	1.54	No	No	0	7	6
292	R:R:L137	R:R:V328	1.49	Yes	No	0	8	4
293	R:R:L226	R:R:T229	1.47	No	No	0	5	8
294	R:R:P36	R:R:R34	1.44	Yes	No	0	3	2
295	R:R:I38	R:R:L33	1.43	No	No	0	5	4
296	R:R:E326	R:R:T69	1.41	No	No	0	5	7
297	R:R:G162	R:R:W161	1.41	No	Yes	0	4	9
298	R:R:L163	R:R:L166	1.38	No	No	0	4	4
299	R:R:A203	R:R:R206	1.38	No	No	0	5	6
300	R:R:V190	R:R:Y174	1.26	No	No	0	5	4
301	R:R:D195	R:R:H194	1.26	No	No	0	3	1
302	R:R:F275	R:R:K279	1.24	Yes	No	0	3	4
303	R:R:L173	R:R:Y174	1.17	No	No	0	4	4
304	R:R:E234	R:R:R233	1.16	No	No	0	2	4
305	R:R:L57	R:R:W60	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P36	2.95	5	0	3
2	R:R:F44	5.746	5	1	7
3	R:R:F48	4.9425	4	0	6
4	R:R:I70	6.7525	4	2	6
5	R:R:N71	5.0625	4	2	7
6	R:R:W74	8.21	5	2	7
7	R:R:N77	7.2975	4	6	9
8	R:R:D82	6.2675	4	1	9
9	R:R:L89	7.025	4	1	7
10	R:R:I96	4.1675	4	1	5
11	R:R:H101	5.765	4	8	4
12	R:R:W102	5.68571	7	7	8
13	R:R:N119	4.972	5	1	9
14	R:R:L126	4.335	4	6	7
15	R:R:R134	5.24333	6	2	9
16	R:R:L137	5.44	6	2	8
17	R:R:F139	10.1175	4	0	7
18	R:R:R148	10.096	5	2	7
19	R:R:W161	3.444	5	0	9
20	R:R:F211	5.5075	4	0	8
21	R:R:Y222	4.828	5	0	8
22	R:R:V247	4.5375	4	5	7
23	R:R:S250	3.4875	4	5	6
24	R:R:F254	10.544	5	0	8
25	R:R:W255	9.944	5	0	9
26	R:R:F275	3.9125	4	0	3
27	R:R:S287	6.3975	4	0	4
28	R:R:Y290	8.10333	6	1	7
29	R:R:I299	4.195	4	5	7
30	R:R:Y300	8.595	4	4	9
31	R:R:L323	8.656	5	4	5
32	R:R:S327	6.2875	4	2	4
33	W:W:?1	7.421	10	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L284	R:R:P36	11.031	3.28	No	Yes	0	4	3
2	R:R:L284	R:R:S287	12.3714	4.5	No	Yes	0	4	4
3	R:R:F44	R:R:I96	13.4547	3.77	Yes	Yes	1	7	5
4	R:R:F44	R:R:Y290	31.6473	7.22	Yes	Yes	1	7	7
5	R:R:L89	R:R:V47	12.7803	2.98	Yes	No	0	7	6
6	R:R:C294	R:R:V47	11.3935	6.83	No	No	0	7	6
7	R:R:C293	R:R:Y290	78.2035	4.03	No	Yes	1	8	7
8	R:R:C293	R:R:D82	78.4522	6.22	No	Yes	1	8	9
9	R:R:D82	R:R:N296	87.1017	6.73	Yes	No	0	9	9
10	R:R:N296	R:R:Y300	22.2686	9.3	No	Yes	0	9	9
11	R:R:L323	R:R:Y300	16.1313	14.07	Yes	Yes	4	5	9
12	R:R:L323	R:R:T62	13.9479	2.95	Yes	No	0	5	6
13	R:R:N296	R:R:V247	100	8.87	No	Yes	0	9	7
14	R:R:L127	R:R:V247	71.7164	2.98	No	Yes	0	8	7
15	R:R:L127	R:R:V248	58.1394	4.47	No	No	0	8	7
16	R:R:L218	R:R:V248	57.5957	2.98	No	No	0	8	7
17	R:R:L218	R:R:S131	57.0561	3	No	No	0	8	9
18	R:R:S131	R:R:Y222	56.5166	8.9	No	Yes	0	9	8
19	R:R:V245	R:R:Y222	44.377	3.79	No	Yes	0	4	8
20	R:R:L241	R:R:V245	43.4581	2.98	No	No	0	6	4
21	R:R:L241	R:R:R134	44.4571	4.86	No	Yes	0	6	9
22	R:R:R134	R:R:T238	24.0389	3.88	Yes	No	0	9	5
23	R:R:E325	R:R:T238	23.0273	9.88	No	No	0	8	5
24	R:R:E325	R:R:K239	57.6505	4.05	No	No	0	8	7
25	R:R:E321	R:R:K239	43.555	2.7	No	No	0	6	7
26	R:R:E321	R:R:K313	40.714	2.7	No	No	0	6	4
27	R:R:E317	R:R:K313	37.8604	5.4	No	No	0	3	4
28	R:R:E317	R:R:S314	34.9983	5.75	No	No	0	3	4
29	R:R:P316	R:R:S314	32.1278	5.34	No	No	0	5	4
30	R:R:L315	R:R:P316	29.2489	3.28	No	No	0	6	5
31	R:R:L315	R:R:L57	17.6488	2.77	No	No	0	6	5
32	R:R:R134	R:R:T240	24.0769	7.76	Yes	No	2	9	7
33	R:R:E325	R:R:T240	37.3546	9.88	No	No	0	8	7
34	R:R:D133	R:R:W74	30.2647	11.17	No	Yes	2	8	7
35	R:R:L127	R:R:L78	32.073	4.15	No	No	0	8	9
36	R:R:L126	R:R:L78	30.8295	4.15	Yes	No	0	7	9
37	R:R:L126	R:R:N77	26.9643	6.87	Yes	Yes	6	7	9
38	R:R:S250	R:R:V247	58.5483	3.23	Yes	Yes	5	6	7
39	R:R:N292	R:R:S250	44.1789	2.98	No	Yes	0	9	6
40	R:R:N292	R:R:W255	32.8612	7.91	No	Yes	0	9	9
41	R:R:F251	R:R:W255	33.6284	10.02	No	Yes	0	9	9
42	R:R:F251	R:R:I124	45.5235	15.07	No	No	0	9	8
43	R:R:I124	R:R:P214	45.3507	5.08	No	No	0	8	9
44	R:R:P214	W:W:?1	43.5719	5.43	No	Yes	3	9	0
45	R:R:T129	W:W:?1	41.4728	5.85	No	Yes	0	6	0
46	R:R:N77	R:R:W161	19.3517	5.65	Yes	Yes	0	9	9
47	R:R:L92	R:R:W102	33.6115	2.28	No	Yes	0	6	8
48	R:R:L92	R:R:Y290	34.7623	3.52	No	Yes	0	6	7
49	R:R:F104	R:R:W102	14.1587	18.04	No	Yes	0	7	8
50	R:R:F104	R:R:P103	11.3935	13	No	No	0	7	3
51	R:R:A122	R:R:W161	12.6286	3.89	No	Yes	0	6	9
52	R:R:A122	R:R:A164	11.2586	1.79	No	No	0	6	7
53	R:R:L137	R:R:R134	26.8378	6.07	Yes	Yes	2	8	9
54	R:R:I225	R:R:Y222	12.6201	3.63	No	Yes	0	8	8
55	R:R:F135	R:R:I225	11.2081	5.02	No	No	0	8	8
56	R:R:F251	R:R:F252	45.7427	8.57	No	No	0	9	5
57	R:R:F211	R:R:F252	40.4527	6.43	Yes	No	0	8	5
58	R:R:F211	R:R:L212	14.694	3.65	Yes	No	0	8	4
59	R:R:L207	R:R:L212	13.3915	6.92	No	No	0	5	4
60	R:R:I263	R:R:L207	24.216	5.71	No	No	0	5	5
61	R:R:F267	R:R:I263	10.8877	5.02	No	No	0	4	5
62	R:R:F211	R:R:Q259	14.7909	5.86	Yes	No	0	8	8
63	R:R:L207	R:R:Q259	13.4885	6.65	No	No	0	5	8
64	R:R:A203	R:R:I263	10.8877	1.62	No	No	0	5	5
65	R:R:F254	R:R:N292	16.5234	8.46	Yes	No	0	8	9
66	R:R:F254	R:R:F288	35.7402	12.86	Yes	No	0	8	8
67	R:R:F288	R:R:P257	32.8739	7.22	No	No	0	8	9
68	R:R:L256	R:R:P257	31.6768	3.28	No	No	0	5	9
69	R:R:I295	R:R:S250	14.8879	4.64	No	Yes	5	7	6
70	R:R:F254	R:R:I295	28.3005	7.54	Yes	No	0	8	7
71	R:R:I299	R:R:V247	16.418	3.07	Yes	Yes	5	7	7
72	R:R:I295	R:R:I299	14.9764	7.36	No	Yes	5	7	7
73	R:R:F307	R:R:K239	11.7982	21.09	No	No	0	9	7
74	R:R:L256	R:R:V260	40.9965	2.98	No	No	0	5	6
75	R:R:M264	R:R:V260	38.4842	4.56	No	No	0	4	6
76	R:R:L278	R:R:M264	35.9552	5.65	No	No	0	4	4
77	R:R:L278	R:R:M265	25.9948	5.65	No	No	0	4	4
78	R:R:F275	R:R:M265	23.4404	4.98	Yes	No	0	3	4
79	R:R:F275	R:R:L268	10.4999	3.65	Yes	No	0	3	2
80	R:R:I70	R:R:W74	10.424	8.22	Yes	Yes	2	6	7
81	R:R:N71	R:R:R148	16.0892	4.82	Yes	Yes	2	7	7
82	R:R:F44	R:R:S287	16.38	5.28	Yes	Yes	0	7	4
83	R:R:L89	R:R:Y290	21.7796	11.72	Yes	Yes	1	7	7
84	R:R:N71	R:R:T240	14.8752	5.85	Yes	No	2	7	7
85	R:R:D133	R:R:L137	21.0083	5.43	No	Yes	2	8	8
86	R:R:T129	R:R:W74	41.3295	4.85	No	Yes	0	6	7
87	R:R:F211	R:R:L256	14.5675	6.09	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T129	R:R:W74	4.85	0	No	Yes	6	7	1	2
R:R:I124	R:R:P214	5.08	0	No	No	8	9	2	1
R:R:L125	R:R:L163	5.54	3	No	No	6	4	1	1
R:R:L125	W:W:?1	8.24	3	No	Yes	6	0	1	0
R:R:A128	W:W:?1	9.38	0	No	Yes	7	0	1	0
R:R:T129	W:W:?1	5.85	0	No	Yes	6	0	1	0
R:R:L152	R:R:L156	4.15	0	No	No	3	5	2	1
R:R:L156	W:W:?1	3.66	0	No	Yes	5	0	1	0
R:R:V159	W:W:?1	9.86	0	No	Yes	1	0	1	0
R:R:L163	W:W:?1	3.66	3	No	Yes	4	0	1	0
R:R:L209	R:R:V205	2.98	0	No	No	4	3	1	2
R:R:L209	W:W:?1	3.66	0	No	Yes	4	0	1	0
R:R:P214	R:R:W213	4.05	3	No	No	9	5	1	1
R:R:T217	R:R:W213	10.92	3	No	No	5	5	1	1
R:R:W213	W:W:?1	19.59	3	No	Yes	5	0	1	0
R:R:P214	W:W:?1	5.43	3	No	Yes	9	0	1	0
R:R:T217	W:W:?1	4.88	3	No	Yes	5	0	1	0
R:R:I155	R:R:V159	1.54	0	No	No	2	1	2	1
R:R:L163	R:R:L166	1.38	3	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
72.73	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
61.54	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
61.54	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
54.55	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
54.55	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
47.06	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
41.18	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
40.00	Single	5KW2	PubChem 133053953	5KW2-FFA1 (GPR40)-PubChem 133053953
38.46	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
33.33	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
31.58	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
25.00	Single	8IYX	YL-365	8IYX-GPR34-YL-365
18.75	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.38	Single	5XSZ	Glyceryl Mono-oleate	5XSZ-LPA₆-Glyceryl Mono-oleate
13.33	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.76	Consensus	d1_on_allo	Other Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.11	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
11.11	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
10.00	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
10.00	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.52	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
9.52	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.33	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
8.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
6.67	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
5.88	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.88	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
5.88	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.56	Single	7LJC	Mevidalen	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.56	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.56	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.56	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
5.56	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.56	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.00	Consensus	adgrf1_on_allo	Other Ligand	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
4.76	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
4.55	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
4.55	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
4.55	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
4.55	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
4.55	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
4.55	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
4.55	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.35	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
4.35	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
4.35	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.35	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
4.17	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.17	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
4.17	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
4.17	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
4.17	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
4.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
3.85	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
3.85	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
3.45	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.33	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.23	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.03	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.94	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2

PDB Summary
PDB	5O9H
Class	A
SubFamily	Peptide
Type	Complement peptide
SubType	C5a1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	NDT9513727
Protein Partners	-
PDB Resolution	2.7
Date	2018-01-10
D.O.I.	10.1038/nature25025

Net Summary
I_min	2.98
Number of Linked Nodes	279
Number of Links	305
Number of Hubs	33
Number of Links mediated by Hubs	134
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	53124
Length Of Smallest Path	3
Average Path Length	15.8651
Length of Longest Path	34
Minimum Path Strength	1.215
Average Path Strength	5.85435
Maximum Path Strength	16.475
Minimum Path Correlation	0.7
Average Path Correlation	0.932423
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	50.0321
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.8874
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9P2
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	9P2
Name	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine
Synonyms
Identifier	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine
Formula	C36 H35 N3 O4
Molecular Weight	573.681
SMILES	CCCCn1c(c(nc1c2ccccc2)c3ccccc3)CN(Cc4ccc5c(c4)OCO5)Cc6ccc7c(c6)OCO7
PubChem	10210160
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	0
Total Bonds	84
Total Aromatic Bonds	29


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>5O9H_Chain_R N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L A C L A L P A L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P A W C Q R F R G A G L A W I L C A V A W G L A L L L T I P S A L Y R V V R E E Y F P P K V L C G V D H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S A R E T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q K S L P E L L R E V L T E E S V V R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6C1Q	A	Peptide	Complement peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/&β;1/&γ;2	3.39	2023-10-18	10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/&β;1/&γ;2	3.89	2023-10-18	10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/&β;1/&γ;2	3.21	2023-10-18	10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/&β;1/&γ;2	3.31	2023-10-18	10.1016/j.cell.2023.09.020
	5O9H (Dimer)	A	Peptide	Complement peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	10.1038/nature25025

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