psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N31	R:R:T32	4.39	No	No	0	1	4
2	R:R:D37	R:R:L33	4.07	No	No	0	4	4
3	R:R:H99	R:R:L33	7.71	No	No	0	2	4
4	R:R:K280	R:R:R34	11.14	No	No	0	2	2
5	R:R:P36	R:R:V35	3.53	Yes	No	0	3	3
6	R:R:L39	R:R:V35	2.98	No	No	0	5	3
7	R:R:D37	R:R:P36	3.22	No	Yes	0	4	3
8	R:R:L281	R:R:P36	3.28	No	Yes	0	5	3
9	R:R:L284	R:R:P36	3.28	No	Yes	0	4	3
10	R:R:D37	R:R:H100	5.04	No	No	0	4	4
11	R:R:A40	R:R:S287	3.42	No	Yes	0	6	4
12	R:R:F93	R:R:L41	12.18	No	No	1	7	5
13	R:R:I96	R:R:L41	4.28	Yes	No	1	5	5
14	R:R:L41	R:R:V97	2.98	No	No	1	5	3
15	R:R:I43	R:R:S287	12.39	No	Yes	0	5	4
16	R:R:F44	R:R:L89	8.53	Yes	Yes	1	7	7
17	R:R:F44	R:R:I96	3.77	Yes	Yes	1	7	5
18	R:R:F44	R:R:V286	3.93	Yes	No	0	7	5
19	R:R:F44	R:R:S287	5.28	Yes	Yes	0	7	4
20	R:R:F44	R:R:Y290	7.22	Yes	Yes	1	7	7
21	R:R:L89	R:R:V47	2.98	Yes	No	0	7	6
22	R:R:C294	R:R:V47	6.83	No	No	0	7	6
23	R:R:F48	R:R:V52	5.24	Yes	No	0	6	5
24	R:R:F48	R:R:L89	4.87	Yes	Yes	0	6	7
25	R:R:F48	R:R:P90	7.22	Yes	No	0	6	9
26	R:R:C294	R:R:V50	3.42	No	No	0	7	6
27	R:R:I298	R:R:V50	3.07	No	No	0	7	6
28	R:R:F83	R:R:V52	5.24	No	No	0	8	5
29	R:R:G54	R:R:P297	4.06	No	No	0	7	9
30	R:R:A79	R:R:N55	3.13	No	No	0	8	9
31	R:R:D82	R:R:N55	5.39	Yes	No	0	9	9
32	R:R:N55	R:R:P297	6.52	No	No	0	9	9
33	R:R:A79	R:R:V58	3.39	No	No	0	8	8
34	R:R:V58	R:R:Y300	3.79	No	Yes	4	8	9
35	R:R:L323	R:R:V58	4.47	Yes	No	4	5	8
36	R:R:L76	R:R:V59	4.47	No	No	0	6	7
37	R:R:F64	R:R:W60	14.03	No	No	0	4	4
38	R:R:L319	R:R:V61	4.47	No	No	0	5	6
39	R:R:R320	R:R:V61	6.54	No	No	0	6	6
40	R:R:A72	R:R:T62	3.36	No	No	0	7	6
41	R:R:L76	R:R:T62	5.9	No	No	0	6	6
42	R:R:E65	R:R:T324	14.11	No	No	0	5	5
43	R:R:I70	R:R:W74	8.22	Yes	Yes	2	6	7
44	R:R:I70	R:R:R148	13.78	Yes	Yes	2	6	7
45	R:R:A153	R:R:I70	3.25	No	Yes	2	7	6
46	R:R:N71	R:R:R134	3.62	Yes	Yes	2	7	9
47	R:R:N71	R:R:R148	4.82	Yes	Yes	2	7	7
48	R:R:N71	R:R:T240	5.85	Yes	No	2	7	7
49	R:R:N71	R:R:S327	5.96	Yes	Yes	2	7	4
50	R:R:I73	R:R:W154	21.14	No	No	0	6	3
51	R:R:T129	R:R:W74	4.85	No	Yes	0	6	7
52	R:R:I130	R:R:W74	12.92	No	Yes	0	8	7
53	R:R:D133	R:R:W74	11.17	No	Yes	2	8	7
54	R:R:A153	R:R:W74	3.89	No	Yes	2	7	7
55	R:R:F75	R:R:Y300	7.22	No	Yes	4	8	9
56	R:R:F75	R:R:L323	15.83	No	Yes	4	8	5
57	R:R:L126	R:R:N77	6.87	Yes	Yes	6	7	9
58	R:R:N77	R:R:W154	5.65	Yes	No	0	9	3
59	R:R:C157	R:R:N77	11.02	No	Yes	6	6	9
60	R:R:N77	R:R:W161	5.65	Yes	Yes	0	9	9
61	R:R:L126	R:R:L78	4.15	Yes	No	0	7	9
62	R:R:L127	R:R:L78	4.15	No	No	0	8	9
63	R:R:L84	R:R:V80	2.98	No	No	0	6	5
64	R:R:V80	R:R:W161	3.68	No	Yes	0	5	9
65	R:R:D82	R:R:N119	6.73	Yes	Yes	1	9	9
66	R:R:C293	R:R:D82	6.22	No	Yes	1	8	9
67	R:R:D82	R:R:N296	6.73	Yes	No	0	9	9
68	R:R:F83	R:R:L87	4.87	No	No	0	8	4
69	R:R:A85	R:R:N119	4.69	No	Yes	0	6	9
70	R:R:A85	R:R:Y290	4	No	Yes	0	6	7
71	R:R:A88	R:R:L112	4.73	No	No	0	6	5
72	R:R:A88	R:R:L115	4.73	No	No	0	6	5
73	R:R:L89	R:R:Y290	11.72	Yes	Yes	1	7	7
74	R:R:A91	R:R:F104	5.55	No	No	0	6	7
75	R:R:L92	R:R:Y290	3.52	No	Yes	0	6	7
76	R:R:F93	R:R:V97	3.93	No	No	1	7	3
77	R:R:S95	R:R:W102	4.94	No	Yes	0	4	8
78	R:R:H100	R:R:I96	3.98	No	Yes	1	4	5
79	R:R:I96	R:R:S283	4.64	Yes	No	1	5	4
80	R:R:H101	R:R:Q98	6.18	Yes	No	8	4	4
81	R:R:P103	R:R:Q98	3.16	No	No	8	3	4
82	R:R:H100	R:R:S283	5.58	No	No	1	4	4
83	R:R:H101	R:R:P103	6.1	Yes	No	8	4	3
84	R:R:H101	R:R:K185	5.24	Yes	No	0	4	3
85	R:R:H101	R:R:V186	5.54	Yes	No	0	4	6
86	R:R:F104	R:R:W102	18.04	No	Yes	0	7	8
87	R:R:C109	R:R:W102	3.92	No	Yes	7	9	8
88	R:R:C188	R:R:W102	5.22	No	Yes	7	9	8
89	R:R:F104	R:R:P103	13	No	No	0	7	3
90	R:R:A108	R:R:L112	3.15	No	No	0	5	5
91	R:R:C109	R:R:V177	3.42	No	No	0	9	4
92	R:R:C109	R:R:C188	7.28	No	No	7	9	9
93	R:R:P113	R:R:R175	8.65	No	No	0	6	5
94	R:R:L117	R:R:S114	3	No	No	0	4	5
95	R:R:A172	R:R:S114	3.42	No	No	0	4	5
96	R:R:I116	R:R:N119	4.25	No	Yes	0	6	9
97	R:R:I116	R:R:Y290	18.13	No	Yes	0	6	7
98	R:R:L117	R:R:S171	3	No	No	0	4	5
99	R:R:L118	R:R:L165	4.15	No	No	0	5	4
100	R:R:L118	R:R:T168	8.84	No	No	0	5	6
101	R:R:N119	R:R:S123	4.47	Yes	No	0	9	9
102	R:R:C293	R:R:N119	4.72	No	Yes	1	8	9
103	R:R:M120	R:R:Y121	8.38	No	No	0	7	7
104	R:R:M120	R:R:W255	16.29	No	Yes	0	7	9
105	R:R:L167	R:R:Y121	12.89	No	No	0	4	7
106	R:R:A122	R:R:W161	3.89	No	Yes	0	6	9
107	R:R:I124	R:R:P214	5.08	No	No	0	8	9
108	R:R:F251	R:R:I124	15.07	No	No	0	9	8
109	R:R:L125	R:R:L163	5.54	No	No	3	6	4
110	R:R:L125	W:W:?1	8.24	No	Yes	3	6	0
111	R:R:C157	R:R:L126	3.17	No	Yes	6	6	7
112	R:R:A160	R:R:L126	3.15	No	Yes	0	6	7
113	R:R:L127	R:R:V247	2.98	No	Yes	0	8	7
114	R:R:L127	R:R:V248	4.47	No	No	0	8	7
115	R:R:A128	W:W:?1	9.38	No	Yes	0	7	0
116	R:R:T129	W:W:?1	5.85	No	Yes	0	6	0
117	R:R:I130	R:R:V244	3.07	No	No	0	8	7
118	R:R:L218	R:R:S131	3	No	No	0	8	9
119	R:R:S131	R:R:Y222	8.9	No	Yes	0	9	8
120	R:R:D133	R:R:L137	5.43	No	Yes	2	8	8
121	R:R:D133	R:R:R148	16.68	No	Yes	2	8	7
122	R:R:L137	R:R:R134	6.07	Yes	Yes	2	8	9
123	R:R:R134	R:R:T238	3.88	Yes	No	0	9	5
124	R:R:R134	R:R:T240	7.76	Yes	No	2	9	7
125	R:R:L241	R:R:R134	4.86	No	Yes	0	6	9
126	R:R:R134	R:R:S327	5.27	Yes	Yes	2	9	4
127	R:R:F135	R:R:F139	16.08	No	Yes	0	8	7
128	R:R:F135	R:R:I225	5.02	No	No	0	8	8
129	R:R:L136	R:R:W143	3.42	No	No	0	5	5
130	R:R:C144	R:R:L137	6.35	No	Yes	0	5	8
131	R:R:L137	R:R:R148	7.29	Yes	Yes	2	8	7
132	R:R:L137	R:R:S327	6.01	Yes	Yes	2	8	4
133	R:R:F139	R:R:V138	10.49	Yes	No	0	7	8
134	R:R:F139	R:R:R228	11.76	Yes	No	0	7	5
135	R:R:F147	R:R:W143	20.04	No	No	0	4	5
136	R:R:Q145	R:R:V328	4.3	No	No	0	5	4
137	R:R:F147	R:R:R146	9.62	No	No	0	4	5
138	R:R:R148	R:R:S327	7.91	Yes	Yes	2	7	4
139	R:R:L152	R:R:L156	4.15	No	No	0	3	5
140	R:R:L156	W:W:?1	3.66	No	Yes	0	5	0
141	R:R:V159	W:W:?1	9.86	No	Yes	0	1	0
142	R:R:L163	W:W:?1	3.66	No	Yes	3	4	0
143	R:R:I169	R:R:P170	3.39	No	No	0	3	8
144	R:R:D191	R:R:Y174	3.45	No	No	0	4	4
145	R:R:C188	R:R:R175	4.18	No	No	0	9	5
146	R:R:G189	R:R:R175	3	No	No	0	4	5
147	R:R:E179	R:R:Y181	12.35	No	No	0	2	1
148	R:R:E180	R:R:L187	5.3	No	No	0	1	4
149	R:R:F182	R:R:Y181	6.19	No	No	0	3	1
150	R:R:E199	R:R:H194	14.77	No	No	0	4	1
151	R:R:D195	R:R:R197	4.76	No	No	0	3	1
152	R:R:D195	R:R:R198	7.15	No	No	0	3	3
153	R:R:F267	R:R:R200	16.03	No	No	0	4	3
154	R:R:R206	R:R:V202	6.54	No	No	0	6	5
155	R:R:A203	R:R:S266	3.42	No	No	0	5	5
156	R:R:F267	R:R:I204	5.02	No	No	0	4	3
157	R:R:L209	R:R:V205	2.98	No	No	0	4	3
158	R:R:L207	R:R:L212	6.92	No	No	0	5	4
159	R:R:L207	R:R:Q259	6.65	No	No	0	5	8
160	R:R:I263	R:R:L207	5.71	No	No	0	5	5
161	R:R:L209	W:W:?1	3.66	No	Yes	0	4	0
162	R:R:F211	R:R:L212	3.65	Yes	No	0	8	4
163	R:R:F211	R:R:F252	6.43	Yes	No	0	8	5
164	R:R:F211	R:R:L256	6.09	Yes	No	0	8	5
165	R:R:F211	R:R:Q259	5.86	Yes	No	0	8	8
166	R:R:P214	R:R:W213	4.05	No	No	3	9	5
167	R:R:T217	R:R:W213	10.92	No	No	3	5	5
168	R:R:W213	W:W:?1	19.59	No	Yes	3	5	0
169	R:R:P214	W:W:?1	5.43	No	Yes	3	9	0
170	R:R:F252	R:R:L215	14.61	No	No	0	5	5
171	R:R:I220	R:R:L216	4.28	No	No	0	3	2
172	R:R:T217	W:W:?1	4.88	No	Yes	3	5	0
173	R:R:L218	R:R:V248	2.98	No	No	0	8	7
174	R:R:C221	R:R:Y222	4.03	No	Yes	0	6	8
175	R:R:I225	R:R:Y222	3.63	No	Yes	0	8	8
176	R:R:V244	R:R:Y222	3.79	No	Yes	0	7	8
177	R:R:V245	R:R:Y222	3.79	No	Yes	0	4	8
178	R:R:R228	R:R:T235	3.88	No	No	0	5	4
179	R:R:T229	R:R:T235	3.14	No	No	0	8	4
180	R:R:S237	R:R:T229	3.2	No	No	0	7	8
181	R:R:S231	R:R:W230	3.71	No	No	0	4	4
182	R:R:A232	R:R:T235	3.36	No	No	0	5	4
183	R:R:L241	R:R:S237	4.5	No	No	0	6	7
184	R:R:K242	R:R:S237	6.12	No	No	0	6	7
185	R:R:E325	R:R:T238	9.88	No	No	0	8	5
186	R:R:F307	R:R:K239	21.09	No	No	0	9	7
187	R:R:E325	R:R:K239	4.05	No	No	0	8	7
188	R:R:E325	R:R:T240	9.88	No	No	0	8	7
189	R:R:L241	R:R:V245	2.98	No	No	0	6	4
190	R:R:A246	R:R:I299	3.25	No	Yes	0	5	7
191	R:R:S250	R:R:V247	3.23	Yes	Yes	5	6	7
192	R:R:N296	R:R:V247	8.87	No	Yes	0	9	7
193	R:R:I299	R:R:V247	3.07	Yes	Yes	5	7	7
194	R:R:N292	R:R:S250	2.98	No	Yes	0	9	6
195	R:R:I295	R:R:S250	4.64	No	Yes	5	7	6
196	R:R:I299	R:R:S250	3.1	Yes	Yes	5	7	6
197	R:R:F251	R:R:F252	8.57	No	No	0	9	5
198	R:R:F251	R:R:W255	10.02	No	Yes	0	9	9
199	R:R:F254	R:R:I253	3.77	Yes	No	0	8	5
200	R:R:F254	R:R:F288	12.86	Yes	No	0	8	8
201	R:R:F254	R:R:I291	20.09	Yes	No	0	8	5
202	R:R:F254	R:R:N292	8.46	Yes	No	0	8	9
203	R:R:F254	R:R:I295	7.54	Yes	No	0	8	7
204	R:R:W255	R:R:Y258	7.72	Yes	No	0	9	7
205	R:R:A289	R:R:W255	7.78	No	Yes	0	8	9
206	R:R:N292	R:R:W255	7.91	No	Yes	0	9	9
207	R:R:L256	R:R:P257	3.28	No	No	0	5	9
208	R:R:L256	R:R:V260	2.98	No	No	0	5	6
209	R:R:F288	R:R:P257	7.22	No	No	0	8	9
210	R:R:M264	R:R:V260	4.56	No	No	0	4	6
211	R:R:C285	R:R:T261	6.76	No	No	0	6	4
212	R:R:F267	R:R:I263	5.02	No	No	0	4	5
213	R:R:L278	R:R:M264	5.65	No	No	0	4	4
214	R:R:F275	R:R:M265	4.98	Yes	No	0	3	4
215	R:R:L278	R:R:M265	5.65	No	No	0	4	4
216	R:R:L268	R:R:T274	4.42	No	No	0	2	1
217	R:R:F275	R:R:L268	3.65	Yes	No	0	3	2
218	R:R:E269	R:R:P270	3.14	No	No	0	3	3
219	R:R:E269	R:R:S271	4.31	No	No	0	3	4
220	R:R:F275	R:R:P270	5.78	Yes	No	0	3	3
221	R:R:P273	R:R:S272	3.56	No	No	0	2	4
222	R:R:S272	R:R:T274	4.8	No	No	0	4	1
223	R:R:K280	R:R:L276	7.05	No	No	0	2	3
224	R:R:L277	R:R:L281	4.15	No	No	0	1	5
225	R:R:D282	R:R:V286	4.38	No	No	0	4	5
226	R:R:L284	R:R:S287	4.5	No	Yes	0	4	4
227	R:R:C293	R:R:Y290	4.03	No	Yes	1	8	7
228	R:R:I295	R:R:I299	7.36	No	Yes	5	7	7
229	R:R:N296	R:R:Y300	9.3	No	Yes	0	9	9
230	R:R:L323	R:R:Y300	14.07	Yes	Yes	4	5	9
231	R:R:L315	R:R:V301	2.98	No	No	0	6	6
232	R:R:G304	R:R:L318	5.13	No	No	0	8	3
233	R:R:E317	R:R:K313	5.4	No	No	0	3	4
234	R:R:P316	R:R:S314	5.34	No	No	0	5	4
235	R:R:E317	R:R:S314	5.75	No	No	0	3	4
236	R:R:L315	R:R:P316	3.28	No	No	0	6	5
237	R:R:L323	R:R:V322	5.96	Yes	No	0	5	5
238	R:R:R330	R:R:V328	7.85	No	No	0	5	4
239	R:R:L323	R:R:T62	2.95	Yes	No	0	5	6
240	R:R:L215	R:R:T219	2.95	No	No	0	5	4
241	R:R:L227	R:R:T223	2.95	No	No	0	4	2
242	R:R:L278	R:R:T261	2.95	No	No	0	4	4
243	R:R:Q305	R:R:V301	2.87	No	No	0	6	6
244	R:R:I111	R:R:L115	2.85	No	No	0	4	5
245	R:R:I169	R:R:L173	2.85	No	No	0	3	4
246	R:R:Q98	R:R:T94	2.83	No	No	0	4	3
247	R:R:E65	R:R:T69	2.82	No	No	0	5	7
248	R:R:K140	R:R:L136	2.82	No	No	0	6	5
249	R:R:K185	R:R:L187	2.82	No	No	0	3	4
250	R:R:G105	R:R:W102	2.81	No	Yes	0	7	8
251	R:R:A56	R:R:F83	2.77	No	No	0	3	8
252	R:R:L315	R:R:L57	2.77	No	No	0	6	5
253	R:R:L319	R:R:L57	2.77	No	No	0	5	5
254	R:R:A303	R:R:F307	2.77	No	No	0	6	9
255	R:R:E321	R:R:K239	2.7	No	No	0	6	7
256	R:R:E321	R:R:K313	2.7	No	No	0	6	4
257	R:R:F75	R:R:V243	2.62	No	No	0	8	7
258	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
259	R:R:A108	R:R:W102	2.59	No	Yes	0	5	8
260	R:R:F224	R:R:I220	2.51	No	No	0	3	3
261	R:R:F48	R:R:L49	2.44	Yes	No	0	6	4
262	R:R:L92	R:R:W102	2.28	No	Yes	0	6	8
263	R:R:F139	R:R:F224	2.14	Yes	No	0	7	3
264	R:R:G105	R:R:G106	2.11	No	No	0	7	3
265	R:R:C86	R:R:G51	1.96	No	No	0	5	8
266	R:R:C294	R:R:G51	1.96	No	No	0	7	8
267	R:R:A150	R:R:G151	1.95	No	No	0	3	4
268	R:R:P183	R:R:P184	1.95	No	No	0	4	5
269	R:R:A303	R:R:G304	1.95	No	No	0	6	8
270	R:R:G262	R:R:T261	1.82	No	No	0	5	4
271	R:R:A122	R:R:A164	1.79	No	No	0	6	7
272	R:R:G149	R:R:I70	1.76	No	Yes	0	5	6
273	R:R:G210	R:R:M120	1.75	No	No	0	6	7
274	R:R:G54	R:R:L53	1.71	No	No	0	7	4
275	R:R:A72	R:R:T69	1.68	No	No	0	7	7
276	R:R:A72	R:R:T324	1.68	No	No	0	7	5
277	R:R:K140	R:R:P141	1.67	No	No	0	6	8
278	R:R:G306	R:R:Q305	1.64	No	No	0	7	6
279	R:R:A66	R:R:I73	1.62	No	No	0	5	6
280	R:R:A150	R:R:I73	1.62	No	No	0	3	6
281	R:R:A203	R:R:I263	1.62	No	No	0	5	5
282	R:R:V42	R:R:V46	1.6	No	No	0	5	4
283	R:R:V46	R:R:V50	1.6	No	No	0	4	6
284	R:R:S114	R:R:T168	1.6	No	No	0	5	6
285	R:R:C144	R:R:L136	1.59	No	No	0	5	5
286	R:R:A63	R:R:L76	1.58	No	No	0	3	6
287	R:R:A164	R:R:L118	1.58	No	No	0	7	5
288	R:R:T219	R:R:T223	1.57	No	No	0	4	2
289	R:R:I155	R:R:V159	1.54	No	No	0	2	1
290	R:R:I204	R:R:V208	1.54	No	No	0	3	4
291	R:R:I298	R:R:V302	1.54	No	No	0	7	6
292	R:R:L137	R:R:V328	1.49	Yes	No	0	8	4
293	R:R:L226	R:R:T229	1.47	No	No	0	5	8
294	R:R:P36	R:R:R34	1.44	Yes	No	0	3	2
295	R:R:I38	R:R:L33	1.43	No	No	0	5	4
296	R:R:E326	R:R:T69	1.41	No	No	0	5	7
297	R:R:G162	R:R:W161	1.41	No	Yes	0	4	9
298	R:R:L163	R:R:L166	1.38	No	No	0	4	4
299	R:R:A203	R:R:R206	1.38	No	No	0	5	6
300	R:R:V190	R:R:Y174	1.26	No	No	0	5	4
301	R:R:D195	R:R:H194	1.26	No	No	0	3	1
302	R:R:F275	R:R:K279	1.24	Yes	No	0	3	4
303	R:R:L173	R:R:Y174	1.17	No	No	0	4	4
304	R:R:E234	R:R:R233	1.16	No	No	0	2	4
305	R:R:L57	R:R:W60	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P36	2.95	5	0	3
2	R:R:F44	5.746	5	1	7
3	R:R:F48	4.9425	4	0	6
4	R:R:I70	6.7525	4	2	6
5	R:R:N71	5.0625	4	2	7
6	R:R:W74	8.21	5	2	7
7	R:R:N77	7.2975	4	6	9
8	R:R:D82	6.2675	4	1	9
9	R:R:L89	7.025	4	1	7
10	R:R:I96	4.1675	4	1	5
11	R:R:H101	5.765	4	8	4
12	R:R:W102	5.68571	7	7	8
13	R:R:N119	4.972	5	1	9
14	R:R:L126	4.335	4	6	7
15	R:R:R134	5.24333	6	2	9
16	R:R:L137	5.44	6	2	8
17	R:R:F139	10.1175	4	0	7
18	R:R:R148	10.096	5	2	7
19	R:R:W161	3.444	5	0	9
20	R:R:F211	5.5075	4	0	8
21	R:R:Y222	4.828	5	0	8
22	R:R:V247	4.5375	4	5	7
23	R:R:S250	3.4875	4	5	6
24	R:R:F254	10.544	5	0	8
25	R:R:W255	9.944	5	0	9
26	R:R:F275	3.9125	4	0	3
27	R:R:S287	6.3975	4	0	4
28	R:R:Y290	8.10333	6	1	7
29	R:R:I299	4.195	4	5	7
30	R:R:Y300	8.595	4	4	9
31	R:R:L323	8.656	5	4	5
32	R:R:S327	6.2875	4	2	4
33	W:W:?1	7.421	10	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L284	R:R:P36	11.031	3.28	No	Yes	0	4	3
2	R:R:L284	R:R:S287	12.3714	4.5	No	Yes	0	4	4
3	R:R:F44	R:R:I96	13.4547	3.77	Yes	Yes	1	7	5
4	R:R:F44	R:R:Y290	31.6473	7.22	Yes	Yes	1	7	7
5	R:R:L89	R:R:V47	12.7803	2.98	Yes	No	0	7	6
6	R:R:C294	R:R:V47	11.3935	6.83	No	No	0	7	6
7	R:R:C293	R:R:Y290	78.2035	4.03	No	Yes	1	8	7
8	R:R:C293	R:R:D82	78.4522	6.22	No	Yes	1	8	9
9	R:R:D82	R:R:N296	87.1017	6.73	Yes	No	0	9	9
10	R:R:N296	R:R:Y300	22.2686	9.3	No	Yes	0	9	9
11	R:R:L323	R:R:Y300	16.1313	14.07	Yes	Yes	4	5	9
12	R:R:L323	R:R:T62	13.9479	2.95	Yes	No	0	5	6
13	R:R:N296	R:R:V247	100	8.87	No	Yes	0	9	7
14	R:R:L127	R:R:V247	71.7164	2.98	No	Yes	0	8	7
15	R:R:L127	R:R:V248	58.1394	4.47	No	No	0	8	7
16	R:R:L218	R:R:V248	57.5957	2.98	No	No	0	8	7
17	R:R:L218	R:R:S131	57.0561	3	No	No	0	8	9
18	R:R:S131	R:R:Y222	56.5166	8.9	No	Yes	0	9	8
19	R:R:V245	R:R:Y222	44.377	3.79	No	Yes	0	4	8
20	R:R:L241	R:R:V245	43.4581	2.98	No	No	0	6	4
21	R:R:L241	R:R:R134	44.4571	4.86	No	Yes	0	6	9
22	R:R:R134	R:R:T238	24.0389	3.88	Yes	No	0	9	5
23	R:R:E325	R:R:T238	23.0273	9.88	No	No	0	8	5
24	R:R:E325	R:R:K239	57.6505	4.05	No	No	0	8	7
25	R:R:E321	R:R:K239	43.555	2.7	No	No	0	6	7
26	R:R:E321	R:R:K313	40.714	2.7	No	No	0	6	4
27	R:R:E317	R:R:K313	37.8604	5.4	No	No	0	3	4
28	R:R:E317	R:R:S314	34.9983	5.75	No	No	0	3	4
29	R:R:P316	R:R:S314	32.1278	5.34	No	No	0	5	4
30	R:R:L315	R:R:P316	29.2489	3.28	No	No	0	6	5
31	R:R:L315	R:R:L57	17.6488	2.77	No	No	0	6	5
32	R:R:R134	R:R:T240	24.0769	7.76	Yes	No	2	9	7
33	R:R:E325	R:R:T240	37.3546	9.88	No	No	0	8	7
34	R:R:D133	R:R:W74	30.2647	11.17	No	Yes	2	8	7
35	R:R:L127	R:R:L78	32.073	4.15	No	No	0	8	9
36	R:R:L126	R:R:L78	30.8295	4.15	Yes	No	0	7	9
37	R:R:L126	R:R:N77	26.9643	6.87	Yes	Yes	6	7	9
38	R:R:S250	R:R:V247	58.5483	3.23	Yes	Yes	5	6	7
39	R:R:N292	R:R:S250	44.1789	2.98	No	Yes	0	9	6
40	R:R:N292	R:R:W255	32.8612	7.91	No	Yes	0	9	9
41	R:R:F251	R:R:W255	33.6284	10.02	No	Yes	0	9	9
42	R:R:F251	R:R:I124	45.5235	15.07	No	No	0	9	8
43	R:R:I124	R:R:P214	45.3507	5.08	No	No	0	8	9
44	R:R:P214	W:W:?1	43.5719	5.43	No	Yes	3	9	0
45	R:R:T129	W:W:?1	41.4728	5.85	No	Yes	0	6	0
46	R:R:N77	R:R:W161	19.3517	5.65	Yes	Yes	0	9	9
47	R:R:L92	R:R:W102	33.6115	2.28	No	Yes	0	6	8
48	R:R:L92	R:R:Y290	34.7623	3.52	No	Yes	0	6	7
49	R:R:F104	R:R:W102	14.1587	18.04	No	Yes	0	7	8
50	R:R:F104	R:R:P103	11.3935	13	No	No	0	7	3
51	R:R:A122	R:R:W161	12.6286	3.89	No	Yes	0	6	9
52	R:R:A122	R:R:A164	11.2586	1.79	No	No	0	6	7
53	R:R:L137	R:R:R134	26.8378	6.07	Yes	Yes	2	8	9
54	R:R:I225	R:R:Y222	12.6201	3.63	No	Yes	0	8	8
55	R:R:F135	R:R:I225	11.2081	5.02	No	No	0	8	8
56	R:R:F251	R:R:F252	45.7427	8.57	No	No	0	9	5
57	R:R:F211	R:R:F252	40.4527	6.43	Yes	No	0	8	5
58	R:R:F211	R:R:L212	14.694	3.65	Yes	No	0	8	4
59	R:R:L207	R:R:L212	13.3915	6.92	No	No	0	5	4
60	R:R:I263	R:R:L207	24.216	5.71	No	No	0	5	5
61	R:R:F267	R:R:I263	10.8877	5.02	No	No	0	4	5
62	R:R:F211	R:R:Q259	14.7909	5.86	Yes	No	0	8	8
63	R:R:L207	R:R:Q259	13.4885	6.65	No	No	0	5	8
64	R:R:A203	R:R:I263	10.8877	1.62	No	No	0	5	5
65	R:R:F254	R:R:N292	16.5234	8.46	Yes	No	0	8	9
66	R:R:F254	R:R:F288	35.7402	12.86	Yes	No	0	8	8
67	R:R:F288	R:R:P257	32.8739	7.22	No	No	0	8	9
68	R:R:L256	R:R:P257	31.6768	3.28	No	No	0	5	9
69	R:R:I295	R:R:S250	14.8879	4.64	No	Yes	5	7	6
70	R:R:F254	R:R:I295	28.3005	7.54	Yes	No	0	8	7
71	R:R:I299	R:R:V247	16.418	3.07	Yes	Yes	5	7	7
72	R:R:I295	R:R:I299	14.9764	7.36	No	Yes	5	7	7
73	R:R:F307	R:R:K239	11.7982	21.09	No	No	0	9	7
74	R:R:L256	R:R:V260	40.9965	2.98	No	No	0	5	6
75	R:R:M264	R:R:V260	38.4842	4.56	No	No	0	4	6
76	R:R:L278	R:R:M264	35.9552	5.65	No	No	0	4	4
77	R:R:L278	R:R:M265	25.9948	5.65	No	No	0	4	4
78	R:R:F275	R:R:M265	23.4404	4.98	Yes	No	0	3	4
79	R:R:F275	R:R:L268	10.4999	3.65	Yes	No	0	3	2
80	R:R:I70	R:R:W74	10.424	8.22	Yes	Yes	2	6	7
81	R:R:N71	R:R:R148	16.0892	4.82	Yes	Yes	2	7	7
82	R:R:F44	R:R:S287	16.38	5.28	Yes	Yes	0	7	4
83	R:R:L89	R:R:Y290	21.7796	11.72	Yes	Yes	1	7	7
84	R:R:N71	R:R:T240	14.8752	5.85	Yes	No	2	7	7
85	R:R:D133	R:R:L137	21.0083	5.43	No	Yes	2	8	8
86	R:R:T129	R:R:W74	41.3295	4.85	No	Yes	0	6	7
87	R:R:F211	R:R:L256	14.5675	6.09	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T129	R:R:W74	4.85	0	No	Yes	6	7	1	2
R:R:I124	R:R:P214	5.08	0	No	No	8	9	2	1
R:R:L125	R:R:L163	5.54	3	No	No	6	4	1	1
R:R:L125	W:W:?1	8.24	3	No	Yes	6	0	1	0
R:R:A128	W:W:?1	9.38	0	No	Yes	7	0	1	0
R:R:T129	W:W:?1	5.85	0	No	Yes	6	0	1	0
R:R:L152	R:R:L156	4.15	0	No	No	3	5	2	1
R:R:L156	W:W:?1	3.66	0	No	Yes	5	0	1	0
R:R:V159	W:W:?1	9.86	0	No	Yes	1	0	1	0
R:R:L163	W:W:?1	3.66	3	No	Yes	4	0	1	0
R:R:L209	R:R:V205	2.98	0	No	No	4	3	1	2
R:R:L209	W:W:?1	3.66	0	No	Yes	4	0	1	0
R:R:P214	R:R:W213	4.05	3	No	No	9	5	1	1
R:R:T217	R:R:W213	10.92	3	No	No	5	5	1	1
R:R:W213	W:W:?1	19.59	3	No	Yes	5	0	1	0
R:R:P214	W:W:?1	5.43	3	No	Yes	9	0	1	0
R:R:T217	W:W:?1	4.88	3	No	Yes	5	0	1	0
R:R:I155	R:R:V159	1.54	0	No	No	2	1	2	1
R:R:L163	R:R:L166	1.38	3	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
72.73	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
61.54	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
54.55	Single	6OBA	GTPL11074	6OBA-β₂-S-Alprenolol-GTPL11074
50.00	Single	8K9L	BMS-986122	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
46.15	Single	8Y72	BMS-986122	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
44.44	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
40.00	Single	5KW2	PubChem 133053953	5KW2-FFA1-PubChem 133053953
38.46	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
38.46	Single	9JCP	LPC	9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50	Single	9CM7	AZ-1729	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
35.71	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
29.41	Single	8YYX	Leukotriene e4	8YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
27.78	Single	8XXV	A1D5Q	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
26.67	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
25.00	Single	8IYX	YL-365	8IYX-GPR34-YL-365
22.22	Single	9IYB	A1D5Q	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.75	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.38	Single	5XSZ	Glyceryl-mono-oleate	5XSZ-LPA₆-Glyceryl-mono-oleate
13.33	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
11.11	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
10.71	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.00	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
10.00	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.00	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.52	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
9.52	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
9.09	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
9.09	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.70	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
8.70	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
8.33	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
8.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.14	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
6.67	Single	9NS9	Compound 187	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
6.25	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.25	Single	9JCP	LPC	9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
5.88	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.88	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
5.88	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.88	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
5.88	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.88	Single	9CM3	Compound 187	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9K1C	DHA	9K1C-FFA1-DHA-Gi1/β1/γ2
5.88	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.56	Single	7LJC	Mevidalen	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
5.56	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
5.56	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
5.56	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ2
5.56	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
5.56	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.26	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
5.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
4.55	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
4.55	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
4.55	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/β1/γ2
4.55	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
4.55	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
4.55	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.55	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
4.55	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.55	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.35	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
4.35	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
4.35	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
4.35	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.35	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
4.35	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.17	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.17	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
4.17	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
4.17	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
4.17	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
3.85	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
3.85	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
3.70	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
3.45	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.33	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.23	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.23	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.23	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
3.12	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
3.03	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.78	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
2.78	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.50	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2

PDB Summary
PDB	5O9H
Class	A
SubFamily	Peptide
Type	Complement Peptide
SubType	C5A1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	NDT9513727
Protein Partners	-
PDB Resolution	2.7
Date	2018-01-10
D.O.I.	doi.org/10.1038/nature25025

Net Summary
I_min	2.98
Number of Linked Nodes	279
Number of Links	305
Number of Hubs	33
Number of Links mediated by Hubs	134
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	53124
Length Of Smallest Path	3
Average Path Length	15.8651
Length of Longest Path	34
Minimum Path Strength	1.215
Average Path Strength	5.85435
Maximum Path Strength	16.475
Minimum Path Correlation	0.7
Average Path Correlation	0.932449
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	50.0309
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.8874
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response • immune system process • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of immune response • activation of immune response • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • taxis • granulocyte chemotaxis • response to chemical • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • system process • nervous system process • cognition • cell population proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • anatomical structure development • system development • developmental process • defense response • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • cellular defense response • sensory perception of chemical stimulus • sensory perception • biological process involved in interspecies interaction between organisms • response to other organism • response to oxygen-containing compound • response to nitrogen compound • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • cellular anatomical structure • apical part of cell • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• cellular anatomical structure • apical part of cell • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9P2
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	9P2
Name	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine
Synonyms
Identifier
Formula	C36 H35 N3 O4
Molecular Weight	573.681
SMILES
PubChem	10210160
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	0
Total Bonds	84
Total Aromatic Bonds	29


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>5O9H_Chain_R N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L A C L A L P A L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P A W C Q R F R G A G L A W I L C A V A W G L A L L L T I P S A L Y R V V R E E Y F P P K V L C G V D H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S A R E T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q K S L P E L L R E V L T E E S V V R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

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