psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D16	A:A:L12	4.07	No	No	0	4	2
2	A:A:E15	A:A:S13	7.19	No	No	0	6	7
3	A:A:D16	A:A:S13	4.42	No	No	0	4	7
4	A:A:I26	A:A:R22	3.76	No	No	0	9	5
5	A:A:S23	B:B:N88	10.43	No	Yes	0	7	7
6	A:A:I26	B:B:K89	8.72	No	Yes	0	9	9
7	A:A:E27	B:B:K89	5.4	No	Yes	0	6	9
8	A:A:D33	A:A:Q29	6.53	No	No	0	5	4
9	A:A:L30	B:B:K78	4.23	No	No	0	5	8
10	A:A:Q31	R:R:R49	4.67	No	No	0	4	6
11	A:A:D33	B:B:K78	8.3	No	No	0	5	8
12	A:A:K34	B:B:L55	9.87	No	No	0	4	6
13	A:A:Q35	R:R:R130	14.02	No	No	0	3	6
14	A:A:R42	A:A:Y37	17.49	No	No	0	9	4
15	A:A:N218	A:A:T40	4.39	No	No	0	4	7
16	A:A:H220	A:A:T40	5.48	No	No	0	7	7
17	A:A:F219	A:A:L41	7.31	Yes	No	0	8	7
18	A:A:I383	A:A:L41	4.28	Yes	No	0	8	7
19	A:A:F219	A:A:L43	4.87	Yes	No	0	8	7
20	A:A:I245	A:A:L43	5.71	No	No	0	7	7
21	A:A:L44	A:A:L46	4.15	No	No	0	9	8
22	A:A:F238	A:A:L44	18.27	Yes	No	0	9	9
23	A:A:I244	A:A:L44	5.71	No	No	0	8	9
24	A:A:L45	A:A:M221	8.48	No	Yes	0	8	8
25	A:A:L46	A:A:R231	3.64	No	Yes	0	8	9
26	A:A:G47	A:A:S51	3.71	No	Yes	17	9	9
27	A:A:G47	A:A:K53	3.49	No	No	17	9	9
28	A:A:F246	A:A:G47	4.52	No	No	0	9	9
29	A:A:D249	A:A:N50	12.12	Yes	No	11	8	6
30	A:A:D252	A:A:N50	8.08	No	No	11	8	6
31	A:A:N50	A:A:R265	7.23	No	Yes	11	6	9
32	A:A:K53	A:A:S51	6.12	No	Yes	17	9	9
33	A:A:S51	A:A:V247	4.85	Yes	No	0	9	7
34	A:A:D223	A:A:K53	12.44	No	No	0	9	9
35	A:A:I56	A:A:N292	4.25	No	Yes	0	7	9
36	A:A:K58	A:A:V57	4.55	No	No	0	9	7
37	A:A:I62	A:A:Q59	4.12	No	No	18	9	9
38	A:A:Q59	A:A:Y63	14.65	No	No	18	9	2
39	A:A:F212	A:A:M60	7.46	No	No	0	9	9
40	A:A:R61	A:A:T210	10.35	No	No	0	8	7
41	A:A:I62	A:A:Y63	8.46	No	No	18	9	2
42	A:A:T369	A:A:Y63	3.75	No	No	0	9	2
43	A:A:F212	A:A:H64	3.39	No	No	0	9	8
44	A:A:A372	A:A:H64	7.32	No	No	0	8	8
45	A:A:K203	A:A:T204	6.01	No	No	0	7	9
46	A:A:F208	A:A:S205	6.61	No	No	0	5	7
47	A:A:G206	B:B:N119	3.39	No	Yes	0	8	9
48	A:A:I207	B:B:L117	8.56	No	No	0	9	9
49	A:A:F208	A:A:G225	4.52	No	No	0	5	9
50	A:A:E209	A:A:K211	13.5	No	No	15	9	4
51	A:A:E209	A:A:H220	6.15	No	No	15	9	7
52	A:A:E209	A:A:F222	13.99	No	No	0	9	7
53	A:A:H220	A:A:K211	19.65	No	No	15	7	4
54	A:A:F212	A:A:F219	12.86	No	Yes	0	9	8
55	A:A:N218	A:A:Q213	9.24	No	No	0	4	3
56	A:A:F219	A:A:V214	5.24	Yes	No	0	8	6
57	A:A:F376	A:A:V214	6.55	Yes	No	0	8	6
58	A:A:D215	A:A:F376	4.78	No	Yes	0	5	8
59	A:A:F219	A:A:V217	6.55	Yes	No	0	8	5
60	A:A:F376	A:A:V217	3.93	Yes	No	1	8	5
61	A:A:V217	R:R:L123	4.47	No	Yes	1	5	6
62	A:A:C379	A:A:F219	6.98	No	Yes	0	8	8
63	A:A:F222	B:B:W99	16.04	No	Yes	0	7	9
64	A:A:V224	A:A:W234	7.36	No	Yes	0	9	9
65	A:A:Q227	B:B:N119	3.96	No	Yes	0	9	9
66	A:A:Q227	B:B:Y145	9.02	No	Yes	0	9	8
67	A:A:E230	A:A:R228	13.96	Yes	No	2	9	9
68	A:A:R228	B:B:T164	6.47	No	No	0	9	6
69	A:A:R228	B:B:D186	9.53	No	No	2	9	9
70	A:A:E230	A:A:R232	5.82	Yes	Yes	2	9	8
71	A:A:E230	B:B:D186	5.2	Yes	No	2	9	9
72	A:A:R231	A:A:W234	4	Yes	Yes	0	9	9
73	A:A:D272	A:A:R231	14.29	No	Yes	16	8	9
74	A:A:I276	A:A:R231	5.01	No	Yes	16	8	9
75	A:A:K233	A:A:R232	6.19	Yes	Yes	2	9	8
76	A:A:R232	B:B:C204	9.75	Yes	Yes	2	8	7
77	A:A:R232	B:B:D228	10.72	Yes	Yes	2	8	9
78	A:A:K233	B:B:Y145	3.58	Yes	Yes	2	9	8
79	A:A:K233	B:B:M188	7.2	Yes	No	2	9	8
80	A:A:K233	B:B:C204	4.85	Yes	Yes	2	9	7
81	A:A:K233	B:B:D228	6.91	Yes	Yes	2	9	9
82	A:A:K233	B:B:D246	5.53	Yes	Yes	2	9	9
83	A:A:I235	A:A:W234	5.87	No	Yes	0	9	9
84	A:A:F238	A:A:W234	4.01	Yes	Yes	0	9	9
85	A:A:Q236	A:A:W281	9.86	No	Yes	3	8	5
86	A:A:Q236	B:B:R314	4.67	No	Yes	3	8	8
87	A:A:C237	B:B:Q75	6.1	No	Yes	0	8	9
88	A:A:F238	A:A:V241	5.24	Yes	No	0	9	9
89	A:A:F238	B:B:W99	14.03	Yes	Yes	0	9	9
90	A:A:D240	A:A:N239	4.04	No	No	3	6	8
91	A:A:N239	B:B:K57	11.19	No	Yes	3	8	9
92	A:A:N239	B:B:W332	14.69	No	Yes	3	8	9
93	A:A:D240	B:B:K57	4.15	No	Yes	3	6	9
94	A:A:I244	A:A:I285	5.89	No	No	0	8	7
95	A:A:I245	A:A:I288	8.83	No	Yes	5	7	9
96	A:A:F290	A:A:I245	3.77	Yes	No	5	9	7
97	A:A:F246	A:A:V248	3.93	No	No	0	9	7
98	A:A:D272	A:A:F246	7.17	No	No	0	8	9
99	A:A:N292	A:A:V247	4.43	Yes	No	0	9	7
100	A:A:A269	A:A:V248	3.39	No	No	0	9	7
101	A:A:F345	A:A:V248	6.55	Yes	No	0	8	7
102	A:A:D249	A:A:S251	7.36	Yes	No	0	8	9
103	A:A:D249	A:A:D252	5.32	Yes	No	11	8	8
104	A:A:D249	A:A:K293	9.68	Yes	No	0	8	9
105	A:A:Q294	A:A:S250	5.78	No	No	0	6	6
106	A:A:L297	A:A:S250	6.01	No	No	0	8	6
107	A:A:L296	A:A:S251	4.5	No	No	0	6	9
108	A:A:D252	A:A:R265	15.48	No	Yes	11	8	9
109	A:A:L297	A:A:Y253	3.52	No	Yes	0	8	8
110	A:A:S306	A:A:Y253	3.82	No	Yes	0	7	8
111	A:A:I308	A:A:Y253	8.46	No	Yes	0	7	8
112	A:A:Y253	A:A:Y311	11.91	Yes	No	0	8	6
113	A:A:E268	A:A:R265	9.3	No	Yes	0	9	9
114	A:A:F312	A:A:L266	3.65	Yes	No	0	8	8
115	A:A:I341	A:A:L266	5.71	No	No	0	8	8
116	A:A:N271	A:A:Q267	11.88	No	No	0	5	4
117	A:A:F345	A:A:L270	10.96	Yes	No	0	8	6
118	A:A:I348	A:A:L270	4.28	No	No	0	4	6
119	A:A:D272	A:A:I276	7	No	No	16	8	8
120	A:A:F273	A:A:V287	5.24	No	No	0	9	6
121	A:A:F273	A:A:F345	7.5	No	Yes	0	9	8
122	A:A:F273	A:A:I348	5.02	No	No	0	9	4
123	A:A:K274	A:A:N278	4.2	No	No	0	5	8
124	A:A:I348	A:A:K274	5.82	No	No	0	4	5
125	A:A:V287	A:A:W277	4.9	No	Yes	0	6	6
126	A:A:S349	A:A:W277	7.41	No	Yes	0	7	6
127	A:A:G353	A:A:W277	4.22	No	Yes	0	4	6
128	A:A:H357	A:A:W277	39.14	No	Yes	0	7	6
129	A:A:N278	A:A:S352	5.96	No	No	0	8	5
130	A:A:N279	A:A:W281	3.39	No	Yes	0	8	5
131	A:A:L282	A:A:N279	13.73	No	No	0	9	8
132	A:A:R280	A:A:W281	9	No	Yes	0	5	5
133	A:A:R280	A:A:R283	5.33	No	No	0	5	3
134	A:A:W281	B:B:D290	7.82	Yes	Yes	3	5	6
135	A:A:W281	B:B:R314	18.99	Yes	Yes	3	5	8
136	A:A:W281	B:B:W332	10.31	Yes	Yes	3	5	9
137	A:A:R356	A:A:T284	10.35	No	No	0	2	4
138	A:A:S286	A:A:Y360	3.82	No	Yes	5	8	8
139	A:A:I382	A:A:S286	6.19	Yes	No	5	6	8
140	A:A:F290	A:A:I288	5.02	Yes	Yes	5	9	9
141	A:A:D378	A:A:I288	12.59	No	Yes	5	7	9
142	A:A:L289	A:A:L291	4.15	No	No	0	9	8
143	A:A:F345	A:A:L289	17.05	Yes	No	0	8	9
144	A:A:F290	A:A:H362	7.92	Yes	No	5	9	9
145	A:A:F290	A:A:T364	9.08	Yes	Yes	5	9	9
146	A:A:F290	A:A:N371	3.62	Yes	No	5	9	9
147	A:A:F290	A:A:I375	3.77	Yes	No	0	9	9
148	A:A:F363	A:A:L291	3.65	Yes	No	0	5	8
149	A:A:K293	A:A:N292	4.2	No	Yes	0	9	9
150	A:A:N292	A:A:T364	4.39	Yes	Yes	0	9	9
151	A:A:N292	A:A:S366	8.94	Yes	No	0	9	9
152	A:A:K338	A:A:Q294	4.07	Yes	No	0	5	6
153	A:A:D295	A:A:L296	6.79	No	No	0	9	6
154	A:A:C365	A:A:D295	4.67	No	No	0	8	9
155	A:A:A298	A:A:V334	3.39	No	No	0	4	4
156	A:A:R333	A:A:V301	3.92	No	No	0	5	7
157	A:A:V301	A:A:V334	6.41	No	No	0	7	4
158	A:A:D331	A:A:L302	4.07	No	No	0	4	2
159	A:A:E309	A:A:K307	8.1	No	No	0	4	6
160	A:A:F312	A:A:I308	3.77	Yes	No	0	8	7
161	A:A:F315	A:A:I308	13.82	Yes	No	0	6	7
162	A:A:E309	A:A:F315	5.83	No	Yes	0	4	6
163	A:A:D310	A:A:Y311	4.6	No	No	0	3	6
164	A:A:F312	A:A:F340	6.43	Yes	Yes	0	8	7
165	A:A:E314	A:A:R317	4.65	No	No	0	6	2
166	A:A:F315	A:A:R336	21.38	Yes	No	0	6	5
167	A:A:F315	A:A:F340	5.36	Yes	Yes	0	6	7
168	A:A:P321	A:A:Y318	4.17	No	Yes	0	5	6
169	A:A:R336	A:A:Y318	7.2	No	Yes	0	5	6
170	A:A:F340	A:A:Y318	8.25	Yes	Yes	12	7	6
171	A:A:K343	A:A:Y318	5.97	Yes	Yes	12	3	6
172	A:A:P321	A:A:T320	3.5	No	No	0	5	1
173	A:A:R336	A:A:T320	3.88	No	No	0	5	1
174	A:A:P321	A:A:Y339	4.17	No	Yes	0	5	3
175	A:A:A324	A:A:Y339	5.34	No	Yes	0	3	3
176	A:A:P326	A:A:T335	3.5	No	No	0	1	4
177	A:A:E327	A:A:E330	16.49	No	No	0	4	3
178	A:A:E330	A:A:K338	6.75	No	Yes	0	3	5
179	A:A:D331	A:A:P332	11.27	No	No	0	4	1
180	A:A:D331	A:A:R333	17.87	No	No	0	4	5
181	A:A:T335	A:A:Y339	8.74	No	Yes	0	4	3
182	A:A:F363	A:A:K338	13.65	Yes	Yes	0	5	5
183	A:A:R342	A:A:Y339	7.2	No	Yes	19	4	3
184	A:A:F363	A:A:Y339	4.13	Yes	Yes	19	5	3
185	A:A:F340	A:A:K343	4.96	Yes	Yes	12	7	3
186	A:A:E344	A:A:F340	12.83	No	Yes	12	5	7
187	A:A:P361	A:A:R342	5.76	No	No	0	5	4
188	A:A:F363	A:A:R342	8.55	Yes	No	19	5	4
189	A:A:E344	A:A:K343	6.75	No	Yes	12	5	3
190	A:A:D347	A:A:K343	9.68	No	Yes	0	4	3
191	A:A:P361	A:A:V346	3.53	No	No	0	5	4
192	A:A:C359	A:A:S349	5.16	No	No	0	5	7
193	A:A:D354	A:A:G353	3.35	No	No	0	3	4
194	A:A:G355	R:R:E215	3.27	No	No	0	2	3
195	A:A:I358	A:A:Y360	10.88	No	Yes	5	4	8
196	A:A:I358	R:R:S213	10.84	No	Yes	5	4	3
197	A:A:H362	A:A:Y360	4.36	No	Yes	5	9	8
198	A:A:D378	A:A:Y360	9.2	No	Yes	5	7	8
199	A:A:D381	A:A:Y360	6.9	Yes	Yes	5	8	8
200	A:A:I382	A:A:Y360	4.84	Yes	Yes	5	6	8
201	A:A:Y360	R:R:S213	7.63	Yes	Yes	5	8	3
202	A:A:D378	A:A:H362	10.08	No	No	5	7	9
203	A:A:N371	A:A:T364	11.7	No	Yes	5	9	9
204	A:A:R374	A:A:T364	9.06	Yes	Yes	5	4	9
205	A:A:C365	A:A:V367	5.12	No	No	0	8	9
206	A:A:D368	A:A:E370	11.69	No	No	5	9	4
207	A:A:D368	A:A:R374	4.76	No	Yes	5	9	4
208	A:A:E370	A:A:R374	13.96	No	Yes	5	4	4
209	A:A:N371	A:A:R374	7.23	No	Yes	5	9	4
210	A:A:F376	A:A:N377	4.83	Yes	No	0	8	4
211	A:A:F376	A:A:K380	6.2	Yes	No	1	8	7
212	A:A:F376	R:R:L123	3.65	Yes	Yes	1	8	6
213	A:A:K380	R:R:P122	3.35	No	Yes	1	7	7
214	A:A:K380	R:R:L123	7.05	No	Yes	1	7	6
215	A:A:D381	A:A:Q385	3.92	Yes	No	5	8	5
216	A:A:D381	R:R:S211	5.89	Yes	No	0	8	5
217	A:A:D381	R:R:S213	5.89	Yes	Yes	5	8	3
218	A:A:I383	A:A:N387	4.25	Yes	No	1	8	8
219	A:A:I383	R:R:P122	3.39	Yes	Yes	1	8	7
220	A:A:I383	R:R:L123	4.28	Yes	Yes	1	8	6
221	A:A:L384	R:R:V119	4.47	No	No	0	6	8
222	A:A:L384	R:R:P122	4.93	No	Yes	0	6	7
223	A:A:Q385	R:R:S213	7.22	No	Yes	5	5	3
224	A:A:Q385	R:R:T214	7.09	No	No	0	5	3
225	A:A:N387	A:A:Y391	8.14	No	Yes	1	8	4
226	A:A:N387	R:R:A118	4.69	No	No	1	8	8
227	A:A:R389	A:A:V394	5.23	No	No	0	4	8
228	A:A:Y391	R:R:E51	7.86	Yes	No	1	4	7
229	A:A:Y391	R:R:L52	3.52	Yes	Yes	1	4	8
230	A:A:Y391	R:R:D114	3.45	Yes	Yes	1	4	8
231	A:A:Y391	R:R:A118	9.34	Yes	No	1	4	8
232	A:A:Y391	R:R:R129	7.2	Yes	Yes	1	4	7
233	A:A:N392	R:R:Q45	5.28	No	No	0	7	5
234	A:A:N392	R:R:N290	14.98	No	Yes	0	7	8
235	A:A:L393	R:R:R115	12.15	No	No	0	8	9
236	B:B:D5	B:B:L7	5.43	No	Yes	0	1	8
237	B:B:D5	B:B:R8	14.29	No	No	0	1	3
238	B:B:L7	G:G:V16	4.47	Yes	No	0	8	7
239	B:B:E12	B:B:N16	10.52	No	No	0	4	1
240	B:B:Q13	B:B:Q17	5.12	No	No	0	1	4
241	B:B:I18	B:B:R22	7.52	No	No	0	7	6
242	B:B:Q259	B:B:R22	4.67	No	No	0	6	6
243	B:B:C25	B:B:Q259	9.16	No	No	0	3	6
244	B:B:S31	B:B:T29	4.8	No	No	0	1	3
245	B:B:L300	B:B:T34	4.42	No	No	0	6	5
246	B:B:N36	G:G:M38	4.21	No	No	0	1	4
247	B:B:I37	B:B:R283	8.77	No	Yes	0	2	9
248	B:B:K301	B:B:P39	3.35	Yes	No	0	5	1
249	B:B:R283	B:B:V40	5.23	Yes	No	20	9	3
250	B:B:D298	B:B:V40	5.84	No	No	20	9	3
251	B:B:I43	B:B:L284	4.28	No	No	0	3	5
252	B:B:R46	B:B:R48	7.46	No	No	0	5	7
253	B:B:T47	B:B:W339	7.28	No	Yes	0	3	9
254	B:B:R48	G:G:N59	4.82	No	Yes	21	7	9
255	B:B:R48	G:G:F61	6.41	No	Yes	21	7	8
256	B:B:R49	B:B:T87	3.88	No	No	0	7	5
257	B:B:R49	G:G:F61	19.24	No	Yes	0	7	8
258	B:B:R52	B:B:T50	11.64	No	No	0	7	3
259	B:B:K337	B:B:T50	7.51	No	No	0	6	3
260	B:B:L51	B:B:W82	11.39	Yes	Yes	0	9	9
261	B:B:L51	B:B:T87	4.42	Yes	No	0	9	5
262	B:B:L336	B:B:L51	4.15	Yes	Yes	0	7	9
263	B:B:I338	B:B:L51	5.71	No	Yes	0	5	9
264	B:B:F335	B:B:R52	11.76	No	No	0	4	7
265	B:B:H54	B:B:I58	7.95	Yes	Yes	7	9	9
266	B:B:H54	B:B:S72	5.58	Yes	Yes	7	9	9
267	B:B:H54	B:B:S74	13.95	Yes	No	0	9	9
268	B:B:H54	B:B:I80	11.93	Yes	No	7	9	8
269	B:B:H54	B:B:W82	9.52	Yes	Yes	7	9	9
270	B:B:D76	B:B:L55	5.43	No	No	0	9	6
271	B:B:A56	B:B:D76	6.18	No	No	0	7	9
272	B:B:K57	B:B:Y59	4.78	Yes	Yes	3	9	8
273	B:B:K57	B:B:Q75	12.2	Yes	Yes	3	9	9
274	B:B:K57	B:B:W332	19.73	Yes	Yes	3	9	9
275	B:B:I58	B:B:S72	6.19	Yes	Yes	7	9	9
276	B:B:C317	B:B:I58	3.27	No	Yes	0	7	9
277	B:B:I58	B:B:L336	11.42	Yes	Yes	7	9	7
278	B:B:Q75	B:B:Y59	12.4	Yes	Yes	3	9	8
279	B:B:M101	B:B:Y59	3.59	No	Yes	0	9	8
280	B:B:W332	B:B:Y59	8.68	Yes	Yes	3	9	8
281	B:B:A60	B:B:C103	3.61	No	No	0	7	8
282	B:B:C317	B:B:M61	4.86	No	No	0	7	6
283	B:B:H62	B:B:R150	22.57	No	Yes	0	6	6
284	B:B:L70	B:B:W63	12.53	No	Yes	0	5	7
285	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
286	B:B:T321	B:B:W63	12.13	No	Yes	0	7	7
287	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
288	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
289	B:B:D66	B:B:R68	4.76	No	No	0	8	5
290	B:B:D66	B:B:L69	4.07	No	Yes	0	8	5
291	B:B:D323	B:B:S67	8.83	No	No	0	7	5
292	B:B:D83	B:B:R68	16.68	No	No	0	8	5
293	B:B:R68	B:B:Y85	17.49	No	No	0	5	4
294	B:B:I81	B:B:L69	5.71	Yes	Yes	10	7	5
295	B:B:D83	B:B:L69	4.07	No	Yes	0	8	5
296	B:B:L69	B:B:Y105	5.86	Yes	Yes	10	5	6
297	B:B:L70	B:B:W82	5.69	No	Yes	0	5	9
298	B:B:C103	B:B:V71	6.83	No	No	0	8	8
299	B:B:S72	B:B:W82	3.71	Yes	Yes	7	9	9
300	B:B:L336	B:B:S72	6.01	Yes	Yes	7	7	9
301	B:B:A73	B:B:V100	3.39	No	No	0	9	9
302	B:B:A73	B:B:C103	3.61	No	No	0	9	8
303	B:B:D76	B:B:S74	10.31	No	No	0	9	9
304	B:B:Q75	B:B:W99	4.38	Yes	Yes	0	9	9
305	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
306	B:B:K78	B:B:P94	5.02	No	No	0	8	5
307	B:B:I93	B:B:L79	5.71	Yes	No	0	7	7
308	B:B:L79	B:B:L95	8.3	No	Yes	0	7	8
309	B:B:C114	B:B:L79	4.76	No	No	0	8	7
310	B:B:I80	B:B:W82	14.09	No	Yes	7	8	9
311	B:B:I80	B:B:K89	4.36	No	Yes	7	8	9
312	B:B:I81	B:B:V90	4.61	Yes	No	10	7	5
313	B:B:H91	B:B:I81	3.98	No	Yes	10	5	7
314	B:B:I81	B:B:Y105	3.63	Yes	Yes	10	7	6
315	B:B:K89	B:B:W82	9.28	Yes	Yes	7	9	9
316	B:B:D83	B:B:T86	10.12	No	No	0	8	6
317	B:B:S84	B:B:Y85	3.82	No	No	0	5	4
318	B:B:Y85	G:G:P60	13.91	No	No	0	4	9
319	B:B:N88	B:B:T86	8.77	Yes	No	0	7	6
320	B:B:H91	B:B:V90	5.54	No	No	10	5	5
321	B:B:H91	B:B:L126	6.43	No	No	0	5	5
322	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
323	B:B:I93	B:B:Y124	3.63	Yes	Yes	0	7	6
324	B:B:I93	B:B:V133	6.14	Yes	No	0	7	4
325	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
326	B:B:L95	B:B:Y124	4.69	Yes	Yes	0	8	6
327	B:B:R96	B:B:V135	3.92	No	No	0	6	4
328	B:B:D118	B:B:S97	8.83	No	No	0	9	8
329	B:B:S98	B:B:W99	4.94	No	Yes	0	8	9
330	B:B:L117	B:B:W99	9.11	No	Yes	0	9	9
331	B:B:C114	B:B:V100	3.42	No	No	0	8	9
332	B:B:C149	B:B:T102	5.07	No	No	0	8	8
333	B:B:A104	B:B:R150	4.15	No	Yes	0	7	6
334	B:B:L126	B:B:Y105	3.52	No	Yes	0	5	6
335	B:B:A106	B:B:F151	4.16	No	Yes	0	6	9
336	B:B:N110	B:B:S108	10.43	No	No	22	4	6
337	B:B:D154	B:B:S108	8.83	No	No	22	6	6
338	B:B:N110	B:B:Y111	4.65	No	No	0	4	4
339	B:B:D154	B:B:N110	5.39	No	No	22	6	4
340	B:B:I123	B:B:Y111	3.63	No	No	0	6	4
341	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
342	B:B:C114	B:B:Y124	5.38	No	Yes	0	8	6
343	B:B:G115	B:B:L146	3.42	No	No	0	9	7
344	B:B:G144	B:B:N119	5.09	No	Yes	0	8	9
345	B:B:E138	B:B:I120	4.1	No	No	0	6	6
346	B:B:C121	B:B:L139	6.35	No	Yes	0	8	9
347	B:B:S122	B:B:Y124	7.63	No	Yes	0	8	6
348	B:B:E138	B:B:S122	4.31	No	No	0	6	8
349	B:B:V135	B:B:Y124	7.57	No	Yes	0	4	6
350	B:B:E130	B:B:N132	9.2	No	No	0	3	3
351	B:B:E138	B:B:V135	4.28	No	No	0	6	4
352	B:B:L139	B:B:R137	3.64	Yes	No	0	9	5
353	B:B:L139	B:B:W169	11.39	Yes	Yes	0	9	8
354	B:B:H142	B:B:L146	5.14	Yes	No	0	9	7
355	B:B:H142	B:B:T159	4.11	Yes	No	8	9	9
356	B:B:H142	B:B:S161	15.34	Yes	No	8	9	9
357	B:B:D163	B:B:H142	8.82	Yes	Yes	8	9	9
358	B:B:H142	B:B:W169	10.58	Yes	Yes	8	9	8
359	B:B:D163	B:B:T143	7.23	Yes	No	0	9	5
360	B:B:G162	B:B:Y145	8.69	No	Yes	0	9	8
361	B:B:D186	B:B:Y145	4.6	No	Yes	2	9	8
362	B:B:M188	B:B:Y145	3.59	No	Yes	2	8	8
363	B:B:C148	B:B:R150	6.96	No	Yes	0	6	6
364	B:B:C149	B:B:T159	3.38	No	No	0	8	9
365	B:B:F151	B:B:I157	10.05	Yes	No	0	9	7
366	B:B:L152	B:B:Q156	3.99	Yes	No	0	3	5
367	B:B:L152	B:B:V158	4.47	Yes	No	0	3	5
368	B:B:L152	B:B:L192	6.92	Yes	No	0	3	5
369	B:B:D170	B:B:N155	8.08	No	No	23	9	3
370	B:B:E172	B:B:N155	10.52	No	No	23	6	3
371	B:B:L168	B:B:Q156	6.65	Yes	No	0	6	5
372	B:B:L168	B:B:V158	5.96	Yes	No	0	6	5
373	B:B:T159	B:B:W169	7.28	No	Yes	8	9	8
374	B:B:S160	B:B:V187	4.85	No	No	0	6	9
375	B:B:L190	B:B:S160	7.51	No	No	0	5	6
376	B:B:G162	B:B:S161	3.71	No	No	0	9	9
377	B:B:D163	B:B:S161	10.31	Yes	No	8	9	9
378	B:B:D163	B:B:T165	7.23	Yes	No	0	9	7
379	B:B:T165	B:B:T181	6.28	No	No	0	7	2
380	B:B:C166	B:B:V187	5.12	No	No	0	8	9
381	B:B:C166	B:B:S201	3.44	No	No	0	8	9
382	B:B:A167	B:B:W169	5.19	No	Yes	8	4	8
383	B:B:A167	B:B:Q176	6.06	No	No	8	4	4
384	B:B:L168	B:B:T177	5.9	Yes	No	0	6	4
385	B:B:L168	B:B:T178	4.42	Yes	No	0	6	4
386	B:B:Q176	B:B:W169	16.43	No	Yes	8	4	8
387	B:B:D170	B:B:E172	5.2	No	No	23	9	6
388	B:B:D170	B:B:T173	7.23	No	No	0	9	5
389	B:B:Q175	B:B:T173	7.09	No	No	0	4	5
390	B:B:Q176	B:B:T179	4.25	No	No	0	4	4
391	B:B:F180	B:B:F199	11.79	Yes	Yes	6	7	9
392	B:B:F180	B:B:W211	15.03	Yes	Yes	6	7	8
393	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
394	B:B:G182	B:B:T181	3.64	No	No	0	6	2
395	B:B:H183	B:B:V187	4.15	Yes	No	0	9	9
396	B:B:H183	B:B:S201	4.18	Yes	No	0	9	9
397	B:B:A203	B:B:H183	8.78	No	Yes	6	8	9
398	B:B:D205	B:B:H183	8.82	Yes	Yes	6	9	9
399	B:B:H183	B:B:K209	14.41	Yes	Yes	6	9	6
400	B:B:D205	B:B:T184	4.34	Yes	No	0	9	3
401	B:B:I232	B:B:S189	6.19	Yes	No	0	8	7
402	B:B:F199	B:B:L190	4.87	Yes	No	0	9	5
403	B:B:F234	B:B:S191	6.61	Yes	No	0	5	8
404	B:B:A193	B:B:F234	5.55	No	Yes	0	4	5
405	B:B:G238	B:B:P194	4.06	No	No	0	7	4
406	B:B:D195	B:B:R197	8.34	No	No	0	5	5
407	B:B:R197	B:B:R214	9.6	No	No	0	5	9
408	B:B:D212	B:B:L198	9.5	No	No	0	9	3
409	B:B:F199	B:B:W211	11.02	Yes	Yes	6	9	8
410	B:B:L210	B:B:V200	5.96	No	Yes	0	5	6
411	B:B:I232	B:B:V200	7.68	Yes	Yes	2	8	6
412	B:B:F234	B:B:V200	9.18	Yes	Yes	0	5	6
413	B:B:F241	B:B:V200	5.24	Yes	Yes	2	6	6
414	B:B:S201	B:B:W211	6.18	No	Yes	0	9	8
415	B:B:G202	B:B:I229	5.29	No	No	0	6	7
416	B:B:A203	B:B:D205	4.63	No	Yes	6	8	9
417	B:B:C204	B:B:D228	9.34	Yes	Yes	2	7	9
418	B:B:D205	B:B:S207	10.31	Yes	No	0	9	5
419	B:B:K209	B:B:W211	9.28	Yes	Yes	6	6	8
420	B:B:C218	B:B:K209	4.85	No	Yes	6	5	6
421	B:B:K209	B:B:T221	10.51	Yes	No	0	6	7
422	B:B:L210	B:B:L255	9.69	No	No	0	5	6
423	B:B:C218	B:B:W211	5.22	No	Yes	6	5	8
424	B:B:D212	B:B:E215	6.5	No	No	24	9	3
425	B:B:D212	B:B:R219	10.72	No	No	24	9	5
426	B:B:E215	B:B:M217	9.47	No	No	0	3	3
427	B:B:E215	B:B:R219	6.98	No	No	24	3	5
428	B:B:C218	G:G:Q18	12.21	No	No	0	5	9
429	B:B:F222	B:B:Q220	7.03	Yes	No	2	8	7
430	B:B:D258	B:B:Q220	14.36	No	No	2	7	7
431	B:B:Q220	G:G:I25	5.49	No	No	2	7	2
432	B:B:T221	G:G:E22	7.06	No	Yes	0	7	9
433	B:B:F222	B:B:F241	12.86	Yes	Yes	2	8	6
434	B:B:F222	B:B:F253	6.43	Yes	Yes	2	8	6
435	B:B:F222	B:B:L255	3.65	Yes	No	0	8	6
436	B:B:D258	B:B:F222	7.17	No	Yes	2	7	8
437	B:B:G224	B:B:T223	3.64	No	No	0	6	2
438	B:B:H225	B:B:I229	3.98	Yes	No	0	9	7
439	B:B:H225	B:B:T243	10.95	Yes	No	2	9	8
440	B:B:H225	B:B:S245	12.55	Yes	No	2	9	9
441	B:B:D247	B:B:H225	5.04	Yes	Yes	2	9	9
442	B:B:H225	B:B:R251	16.93	Yes	Yes	2	9	8
443	B:B:D247	B:B:E226	6.5	Yes	No	0	9	3
444	B:B:D228	B:B:S227	4.42	Yes	No	2	9	6
445	B:B:D246	B:B:S227	5.89	Yes	No	2	9	6
446	B:B:D228	B:B:D246	6.65	Yes	Yes	2	9	9
447	B:B:D246	B:B:N230	12.12	Yes	No	0	9	9
448	B:B:A231	B:B:V276	3.39	No	No	0	5	6
449	B:B:F241	B:B:I232	5.02	Yes	Yes	2	6	8
450	B:B:I232	B:B:T243	4.56	Yes	No	2	8	8
451	B:B:C233	B:B:S277	3.44	No	Yes	0	3	5
452	B:B:F234	B:B:L255	3.65	Yes	No	0	5	6
453	B:B:F235	B:B:P236	10.11	Yes	No	13	6	7
454	B:B:F235	B:B:F278	7.5	Yes	Yes	13	6	7
455	B:B:F235	B:B:G282	4.52	Yes	No	13	6	9
456	B:B:G282	B:B:P236	4.06	No	No	13	9	7
457	B:B:N237	B:B:N239	12.26	No	No	0	5	2
458	B:B:N237	G:G:Y40	4.65	No	No	0	5	6
459	B:B:N239	B:B:R256	10.85	No	No	0	2	9
460	B:B:F241	B:B:T243	5.19	Yes	No	2	6	8
461	B:B:F241	B:B:F253	12.86	Yes	Yes	2	6	6
462	B:B:A242	B:B:F278	4.16	No	Yes	0	4	7
463	B:B:G244	B:B:I273	5.29	No	No	0	5	6
464	B:B:D247	B:B:S245	10.31	Yes	No	2	9	9
465	B:B:D247	B:B:T249	14.45	Yes	No	0	9	6
466	B:B:R251	B:B:T249	6.47	Yes	No	0	8	6
467	B:B:S265	B:B:T249	4.8	No	No	0	2	6
468	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
469	B:B:C250	B:B:I273	6.55	No	No	0	8	6
470	B:B:F253	B:B:R251	9.62	Yes	Yes	2	6	8
471	B:B:E260	B:B:R251	15.12	No	Yes	2	6	8
472	B:B:L252	B:B:L261	8.3	No	Yes	0	7	5
473	B:B:E260	B:B:F253	5.83	No	Yes	2	6	6
474	B:B:D254	B:B:R256	3.57	No	No	0	9	9
475	B:B:D254	B:B:L261	8.14	No	Yes	0	9	5
476	B:B:D258	G:G:I25	5.6	No	No	2	7	2
477	B:B:E260	B:B:T263	5.64	No	No	0	6	1
478	B:B:M262	B:B:Y264	8.38	No	Yes	0	4	5
479	B:B:L285	B:B:Y264	3.52	No	Yes	0	6	5
480	B:B:W297	B:B:Y264	4.82	No	Yes	0	8	5
481	B:B:A302	B:B:Y264	4	No	Yes	0	2	5
482	B:B:H266	B:B:N268	10.2	No	No	0	4	4
483	B:B:I269	B:B:Y289	7.25	No	Yes	0	4	7
484	B:B:C271	B:B:Y289	4.03	Yes	Yes	3	5	7
485	B:B:C271	B:B:D290	4.67	Yes	Yes	3	5	6
486	B:B:C271	B:B:D291	6.22	Yes	No	3	5	8
487	B:B:I273	B:B:Y289	6.04	No	Yes	0	6	7
488	B:B:D290	B:B:T274	5.78	Yes	No	3	6	8
489	B:B:R314	B:B:T274	5.17	Yes	No	3	8	8
490	B:B:L318	B:B:S275	9.01	Yes	No	0	6	8
491	B:B:L318	B:B:S277	4.5	Yes	Yes	25	6	5
492	B:B:G319	B:B:S277	3.71	No	Yes	25	5	5
493	B:B:S277	B:B:V320	4.85	Yes	No	0	5	7
494	B:B:F278	B:B:G282	4.52	Yes	No	13	7	9
495	B:B:F278	B:B:L285	8.53	Yes	No	0	7	6
496	B:B:S279	G:G:D48	5.89	No	Yes	26	9	9
497	B:B:S279	G:G:L50	6.01	No	No	26	9	9
498	B:B:S281	G:G:D48	10.31	No	Yes	0	9	9
499	B:B:D298	B:B:R283	11.91	No	Yes	20	9	9
500	B:B:L300	B:B:R283	9.72	No	Yes	0	6	9
501	B:B:R283	G:G:L51	3.64	Yes	Yes	0	9	6
502	B:B:L284	B:B:V296	4.47	No	Yes	0	5	5
503	B:B:L286	B:B:L318	4.15	No	Yes	0	7	6
504	B:B:L286	B:B:V327	4.47	No	No	0	7	6
505	B:B:A287	B:B:Y289	5.34	No	Yes	0	6	7
506	B:B:G288	B:B:V315	3.68	No	No	0	7	7
507	B:B:D291	B:B:Y289	3.45	No	Yes	3	8	7
508	B:B:N295	B:B:Y289	9.3	Yes	Yes	3	6	7
509	B:B:W297	B:B:Y289	8.68	No	Yes	3	8	7
510	B:B:D290	B:B:R314	17.87	Yes	Yes	3	6	8
511	B:B:D291	B:B:N293	8.08	No	No	0	8	5
512	B:B:F292	B:B:N313	3.62	No	No	0	4	7
513	B:B:C294	B:B:L308	4.76	No	No	0	5	7
514	B:B:C294	B:B:V315	5.12	No	No	0	5	7
515	B:B:N295	B:B:W297	5.65	Yes	No	3	6	8
516	B:B:N295	B:B:R304	4.82	Yes	No	3	6	5
517	B:B:N295	B:B:V307	4.43	Yes	No	3	6	3
518	B:B:A305	B:B:V296	3.39	No	Yes	0	4	5
519	B:B:G306	B:B:V296	3.68	No	Yes	0	4	5
520	B:B:D298	B:B:K301	8.3	No	Yes	0	9	5
521	B:B:D303	B:B:K301	13.83	No	Yes	0	2	5
522	B:B:R304	B:B:V307	3.92	No	No	3	5	3
523	B:B:L308	B:B:W339	11.39	No	Yes	0	7	9
524	B:B:H311	B:B:V315	8.3	Yes	No	0	9	7
525	B:B:H311	B:B:T329	5.48	Yes	No	0	9	8
526	B:B:H311	B:B:S331	6.97	Yes	No	27	9	9
527	B:B:D333	B:B:H311	3.78	Yes	Yes	27	9	9
528	B:B:H311	B:B:K337	5.24	Yes	No	0	9	6
529	B:B:D312	B:B:D333	6.65	No	Yes	0	5	9
530	B:B:N313	B:B:W332	6.78	No	Yes	0	7	9
531	B:B:D333	B:B:N313	4.04	Yes	No	0	9	7
532	B:B:R314	B:B:W332	13.99	Yes	Yes	3	8	9
533	B:B:C317	B:B:S316	3.44	No	No	0	7	9
534	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
535	B:B:G319	B:B:L318	5.13	No	Yes	25	5	6
536	B:B:V320	B:B:V327	4.81	No	No	0	7	6
537	B:B:D323	B:B:T321	7.23	No	No	0	7	7
538	B:B:G324	B:B:T321	3.64	No	No	0	9	7
539	B:B:D323	B:B:M325	8.32	No	No	0	7	5
540	B:B:M325	G:G:P49	6.71	No	No	0	5	7
541	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
542	B:B:T329	B:B:W339	8.49	No	Yes	0	8	9
543	B:B:G330	B:B:L336	5.13	No	Yes	0	5	7
544	B:B:D333	B:B:S331	10.31	Yes	No	27	9	9
545	B:B:D333	B:B:F335	10.75	Yes	No	0	9	4
546	B:B:K337	B:B:W339	9.28	No	Yes	0	6	9
547	B:B:I338	G:G:F61	5.02	No	Yes	0	5	8
548	B:B:N340	G:G:N59	9.54	No	Yes	0	9	9
549	G:G:E22	G:G:Q18	5.1	Yes	No	0	9	9
550	G:G:I25	G:G:R27	12.53	No	No	0	2	8
551	G:G:D36	G:G:K32	8.3	No	No	0	5	5
552	G:G:H44	G:G:Y40	21.78	No	No	0	6	6
553	G:G:E47	G:G:H44	3.69	No	No	0	3	6
554	G:G:D48	G:G:P49	4.83	Yes	No	0	9	7
555	G:G:D48	G:G:L50	6.79	Yes	No	26	9	9
556	G:G:D48	G:G:L51	5.43	Yes	Yes	0	9	6
557	G:G:P55	G:G:V54	3.53	No	No	0	5	6
558	G:G:N59	G:G:P60	6.52	Yes	No	0	9	9
559	G:G:F61	G:G:N59	8.46	Yes	Yes	21	8	9
560	R:R:G8	R:R:P173	6.09	No	No	0	5	4
561	R:R:C9	R:R:V11	3.42	Yes	No	0	8	3
562	R:R:C258	R:R:C9	7.28	No	Yes	4	8	8
563	R:R:C9	R:R:E261	7.6	Yes	No	4	8	4
564	R:R:D12	R:R:H10	8.82	No	No	0	6	3
565	R:R:H10	R:R:Y163	25.04	No	Yes	0	3	3
566	R:R:F265	R:R:V11	19.66	Yes	No	0	4	3
567	R:R:S13	R:R:V15	4.85	No	No	0	5	4
568	R:R:D16	R:R:S13	5.89	Yes	No	0	5	5
569	R:R:S13	R:R:S266	6.52	No	No	0	5	2
570	R:R:D16	R:R:H80	6.3	Yes	No	0	5	4
571	R:R:D16	R:R:F265	7.17	Yes	Yes	4	5	4
572	R:R:D16	R:R:H269	5.04	Yes	Yes	4	5	5
573	R:R:H17	R:R:L18	10.29	No	No	0	5	4
574	R:R:F19	R:R:P20	4.33	No	No	0	5	5
575	R:R:F19	R:R:L23	3.65	No	No	0	5	5
576	R:R:F19	R:R:S270	3.96	No	No	0	5	5
577	R:R:P20	R:R:P21	5.84	No	No	4	5	7
578	R:R:F77	R:R:P20	14.45	Yes	No	4	5	5
579	R:R:F77	R:R:P21	5.78	Yes	No	4	5	7
580	R:R:L23	R:R:S276	4.5	No	Yes	0	5	7
581	R:R:L70	R:R:Y24	10.55	No	Yes	0	8	9
582	R:R:F77	R:R:Y24	6.19	Yes	Yes	0	5	9
583	R:R:A273	R:R:Y24	5.34	No	Yes	0	5	9
584	R:R:S276	R:R:Y24	5.09	Yes	Yes	0	7	9
585	R:R:F26	R:R:V30	7.87	No	No	0	4	6
586	R:R:S276	R:R:V27	8.08	Yes	No	0	7	7
587	R:R:V27	R:R:V280	4.81	No	Yes	0	7	8
588	R:R:I28	R:R:I67	5.89	Yes	No	28	7	6
589	R:R:I28	R:R:L70	5.71	Yes	No	0	7	8
590	R:R:I28	R:R:P71	3.39	Yes	No	0	7	8
591	R:R:G31	R:R:N35	3.39	No	Yes	0	8	9
592	R:R:P283	R:R:T34	6.99	No	No	0	9	7
593	R:R:D63	R:R:N35	6.73	No	Yes	0	9	9
594	R:R:N35	R:R:P283	8.15	Yes	No	0	9	9
595	R:R:A38	R:R:C287	3.61	No	No	0	9	7
596	R:R:L39	R:R:S60	6.01	No	No	0	7	8
597	R:R:R44	R:R:W40	14.99	No	No	0	4	4
598	R:R:Q47	R:R:Y43	14.65	No	No	0	6	4
599	R:R:D296	R:R:R44	9.53	No	No	0	4	4
600	R:R:L52	R:R:Q45	3.99	Yes	No	1	8	5
601	R:R:L56	R:R:Q45	3.99	Yes	No	1	8	5
602	R:R:L52	R:R:N50	4.12	Yes	No	0	8	7
603	R:R:D114	R:R:E51	10.39	Yes	No	1	8	7
604	R:R:E51	R:R:R129	9.3	No	Yes	1	7	7
605	R:R:L52	R:R:L56	6.92	Yes	Yes	1	8	8
606	R:R:I111	R:R:L52	4.28	Yes	Yes	1	9	8
607	R:R:G53	R:R:L56	3.42	No	Yes	0	7	8
608	R:R:A134	R:R:V54	5.09	No	No	0	8	7
609	R:R:C110	R:R:Y55	5.38	No	Yes	0	7	7
610	R:R:I111	R:R:Y55	3.63	Yes	Yes	0	9	7
611	R:R:D114	R:R:Y55	6.9	Yes	Yes	0	8	7
612	R:R:A134	R:R:Y55	5.34	No	Yes	0	8	7
613	R:R:V137	R:R:Y55	6.31	No	Yes	0	5	7
614	R:R:I111	R:R:L56	4.28	Yes	Yes	1	9	8
615	R:R:L56	R:R:Y286	3.52	Yes	Yes	1	8	9
616	R:R:F107	R:R:N58	12.08	Yes	No	9	8	9
617	R:R:N58	R:R:S138	8.94	No	No	9	9	7
618	R:R:N58	R:R:W142	3.39	No	Yes	9	9	9
619	R:R:D63	R:R:L59	4.07	No	No	0	9	9
620	R:R:L59	R:R:S104	4.5	No	No	0	9	9
621	R:R:L108	R:R:L59	4.15	No	No	0	8	9
622	R:R:C279	R:R:D63	7.78	No	No	0	9	9
623	R:R:L70	R:R:Y66	8.21	No	Yes	0	8	7
624	R:R:F97	R:R:Y66	15.47	Yes	Yes	0	7	7
625	R:R:N100	R:R:Y66	8.14	No	Yes	0	8	7
626	R:R:S276	R:R:Y66	3.82	Yes	Yes	0	7	7
627	R:R:C279	R:R:Y66	4.03	No	Yes	0	9	7
628	R:R:C279	R:R:I67	4.91	No	No	0	9	6
629	R:R:F93	R:R:T69	6.49	No	No	0	6	7
630	R:R:I96	R:R:T69	4.56	Yes	No	0	5	7
631	R:R:F97	R:R:T69	3.89	Yes	No	0	7	7
632	R:R:L72	R:R:W83	3.42	No	Yes	0	7	9
633	R:R:F93	R:R:L72	12.18	No	No	0	6	7
634	R:R:W73	R:R:Y76	5.79	No	Yes	0	7	6
635	R:R:W83	R:R:Y76	3.86	Yes	Yes	0	9	6
636	R:R:F167	R:R:Y76	4.13	Yes	Yes	4	4	6
637	R:R:E170	R:R:Y76	10.1	No	Yes	4	4	6
638	R:R:F77	R:R:H269	6.79	Yes	Yes	4	5	5
639	R:R:H79	R:R:I84	7.95	No	No	0	4	3
640	R:R:D81	R:R:H80	21.43	No	No	0	4	4
641	R:R:D81	R:R:H165	11.35	No	Yes	0	4	1
642	R:R:N82	R:R:R160	3.62	No	No	0	5	1
643	R:R:H85	R:R:W83	14.81	No	Yes	0	7	9
644	R:R:C90	R:R:W83	11.75	No	Yes	0	9	9
645	R:R:L158	R:R:W83	3.42	No	Yes	0	5	9
646	R:R:H85	R:R:S89	4.18	No	No	0	7	6
647	R:R:G86	R:R:P87	4.06	No	No	0	8	3
648	R:R:L158	R:R:P87	6.57	No	No	0	5	3
649	R:R:C90	R:R:E157	9.12	No	Yes	14	9	5
650	R:R:C168	R:R:C90	7.28	No	No	14	9	9
651	R:R:K91	R:R:L153	8.46	No	No	0	6	4
652	R:R:E157	R:R:K91	5.4	Yes	No	0	5	6
653	R:R:F93	R:R:L92	4.87	No	No	0	6	5
654	R:R:I96	R:R:L92	5.71	Yes	No	0	5	5
655	R:R:F169	R:R:G94	4.52	No	No	0	4	6
656	R:R:F95	R:R:I96	3.77	Yes	Yes	0	6	5
657	R:R:F95	R:R:T99	7.78	Yes	No	9	6	5
658	R:R:F95	R:R:L146	6.09	Yes	No	9	6	3
659	R:R:F95	R:R:L153	17.05	Yes	No	0	6	4
660	R:R:I96	R:R:N100	4.25	Yes	No	0	5	8
661	R:R:F97	R:R:Y98	7.22	Yes	No	0	7	5
662	R:R:F97	R:R:L272	4.87	Yes	No	0	7	5
663	R:R:R185	R:R:Y98	4.12	Yes	No	0	5	5
664	R:R:L146	R:R:T99	4.42	No	No	9	3	5
665	R:R:N149	R:R:T99	10.24	No	No	0	7	5
666	R:R:I101	R:R:Y102	3.63	No	No	0	8	7
667	R:R:I101	R:R:T275	4.56	No	No	0	8	8
668	R:R:R185	R:R:Y102	12.35	Yes	No	0	5	7
669	R:R:H241	R:R:Y102	5.44	No	No	0	8	7
670	R:R:I103	R:R:W142	7.05	No	Yes	0	7	9
671	R:R:E145	R:R:I103	5.47	No	No	0	7	7
672	R:R:I105	R:R:P193	3.39	No	Yes	0	8	9
673	R:R:F237	R:R:I105	8.79	Yes	No	0	8	8
674	R:R:A106	W:W:?1	6.7	No	Yes	0	6	0
675	R:R:F107	R:R:S138	5.28	Yes	No	9	8	7
676	R:R:F107	R:R:V141	3.93	Yes	No	0	8	7
677	R:R:F107	R:R:W142	9.02	Yes	Yes	9	8	9
678	R:R:D282	R:R:L108	9.5	No	No	0	9	8
679	R:R:L108	R:R:Y286	9.38	No	Yes	0	8	9
680	R:R:C109	R:R:P193	3.77	No	Yes	0	8	9
681	R:R:C109	R:R:L196	4.76	No	No	0	8	6
682	R:R:C110	W:W:?1	10.12	No	Yes	0	7	0
683	R:R:I111	R:R:R115	5.01	Yes	No	0	9	9
684	R:R:I111	R:R:Y286	4.84	Yes	Yes	1	9	9
685	R:R:M197	R:R:S112	6.13	No	No	1	7	9
686	R:R:S112	R:R:S200	6.52	No	No	1	9	8
687	R:R:S112	R:R:Y201	3.82	No	Yes	1	9	8
688	R:R:V113	W:W:?1	9.5	No	Yes	0	6	0
689	R:R:D114	R:R:R129	4.76	Yes	Yes	1	8	7
690	R:R:R115	R:R:Y201	9.26	No	Yes	0	9	8
691	R:R:A120	R:R:Y116	5.34	No	Yes	1	7	8
692	R:R:H121	R:R:Y116	5.44	No	Yes	1	6	8
693	R:R:S200	R:R:Y116	3.82	No	Yes	1	8	8
694	R:R:I204	R:R:Y116	3.63	No	Yes	0	8	8
695	R:R:Y116	W:W:?2	28.65	Yes	Yes	1	8	0
696	R:R:F125	R:R:L117	3.65	Yes	No	0	6	6
697	R:R:A118	R:R:R129	4.15	No	Yes	1	8	7
698	R:R:I204	R:R:V119	7.68	No	No	0	8	8
699	R:R:A120	R:R:H121	4.39	No	No	1	7	6
700	R:R:F125	R:R:H121	9.05	Yes	No	0	6	6
701	R:R:L123	R:R:P122	3.28	Yes	Yes	1	6	7
702	R:R:F125	R:R:R124	5.34	Yes	No	0	6	4
703	R:R:F125	R:R:L128	8.53	Yes	No	0	6	3
704	R:R:R130	R:R:T133	5.17	No	No	0	6	3
705	R:R:V137	W:W:?1	6.33	No	Yes	0	5	0
706	R:R:L146	R:R:W142	3.42	No	Yes	9	3	9
707	R:R:E145	W:W:?1	18.3	No	Yes	0	7	0
708	R:R:G147	R:R:S150	3.71	No	No	0	4	4
709	R:R:N149	R:R:R185	4.82	No	Yes	0	7	5
710	R:R:M181	R:R:P152	3.35	No	No	0	4	3
711	R:R:F154	R:R:H155	3.39	No	No	0	4	4
712	R:R:H155	R:R:W177	32.8	No	Yes	0	4	1
713	R:R:D156	R:R:F159	8.36	No	No	0	5	2
714	R:R:C168	R:R:E157	6.08	No	Yes	14	9	5
715	R:R:E157	R:R:F169	10.49	Yes	No	14	5	4
716	R:R:F159	R:R:K171	34.74	No	No	0	2	3
717	R:R:R160	R:R:T166	14.23	No	No	0	1	3
718	R:R:D161	R:R:Y163	5.75	No	Yes	4	2	3
719	R:R:D161	R:R:H165	3.78	No	Yes	4	2	1
720	R:R:D161	R:R:F167	4.78	No	Yes	4	2	4
721	R:R:R162	R:R:Y163	14.4	No	Yes	0	4	3
722	R:R:H165	R:R:Y163	5.44	Yes	Yes	4	1	3
723	R:R:F167	R:R:H165	5.66	Yes	Yes	4	4	1
724	R:R:E170	R:R:F167	11.66	No	Yes	4	4	4
725	R:R:F167	R:R:F265	4.29	Yes	Yes	4	4	4
726	R:R:C168	R:R:F169	4.19	No	No	14	9	4
727	R:R:E175	R:R:K171	5.4	No	No	0	2	3
728	R:R:F172	R:R:R247	6.41	Yes	No	4	5	4
729	R:R:E261	R:R:F172	9.33	No	Yes	4	4	5
730	R:R:F172	R:R:F265	12.86	Yes	Yes	4	5	4
731	R:R:F172	R:R:Y268	7.22	Yes	No	4	5	5
732	R:R:F172	R:R:H269	3.39	Yes	Yes	4	5	5
733	R:R:M174	R:R:V178	6.09	No	No	0	1	2
734	R:R:M174	R:R:R247	4.96	No	No	0	1	4
735	R:R:M174	R:R:Y251	10.78	No	No	0	1	3
736	R:R:E175	R:R:W177	13.08	No	Yes	0	2	1
737	R:R:V178	R:R:W177	13.48	No	Yes	0	2	1
738	R:R:M181	R:R:W177	3.49	No	Yes	0	4	1
739	R:R:A179	R:R:L252	4.73	No	No	0	1	1
740	R:R:L252	R:R:W180	7.97	No	No	0	1	3
741	R:R:N182	R:R:R185	7.23	No	Yes	0	5	5
742	R:R:L244	R:R:N182	16.48	No	No	0	5	5
743	R:R:F187	R:R:L183	3.65	No	No	0	5	4
744	R:R:V188	R:R:Y184	15.14	No	No	0	4	3
745	R:R:G189	R:R:V188	3.68	No	No	0	6	4
746	R:R:G189	W:W:?1	7.27	No	Yes	0	6	0
747	R:R:F190	R:R:L191	4.87	No	No	0	8	4
748	R:R:F190	R:R:F237	6.43	No	Yes	0	8	8
749	R:R:F190	R:R:H241	28.28	No	No	0	8	8
750	R:R:F192	R:R:P193	4.33	No	Yes	30	5	9
751	R:R:F192	R:R:L196	12.18	No	No	0	5	6
752	R:R:F192	W:W:?1	3.88	No	Yes	30	5	0
753	R:R:P193	W:W:?1	6.98	Yes	Yes	30	9	0
754	R:R:I230	R:R:W194	3.52	Yes	No	0	7	6
755	R:R:V233	R:R:W194	6.13	No	No	0	9	6
756	R:R:L234	R:R:W194	19.36	No	No	0	6	6
757	R:R:L196	W:W:?2	4.41	No	Yes	0	6	0
758	R:R:M197	R:R:Y201	3.59	No	Yes	1	7	8
759	R:R:I230	R:R:M197	4.37	Yes	No	1	7	7
760	R:R:I230	R:R:L198	5.71	Yes	No	0	7	5
761	R:R:L199	W:W:?2	7.35	No	Yes	0	5	0
762	R:R:S200	W:W:?2	6.38	No	Yes	1	8	0
763	R:R:A226	R:R:Y201	4	No	Yes	0	7	8
764	R:R:L229	R:R:Y201	9.38	Yes	Yes	1	8	8
765	R:R:I230	R:R:Y201	6.04	Yes	Yes	1	7	8
766	R:R:R202	R:R:R206	4.26	No	No	1	3	3
767	R:R:R202	W:W:?2	9.04	No	Yes	1	3	0
768	R:R:G203	W:W:?2	5.45	No	Yes	0	4	0
769	R:R:K223	R:R:L205	7.05	No	No	0	6	5
770	R:R:A226	R:R:L205	4.73	No	No	0	7	5
771	R:R:R206	W:W:?2	5.16	No	Yes	1	3	0
772	R:R:K219	R:R:V208	4.55	No	No	0	6	8
773	R:R:I222	R:R:V208	4.61	No	No	0	7	8
774	R:R:S211	R:R:T214	4.8	No	No	0	5	3
775	R:R:Q217	R:R:R216	9.35	No	No	0	4	4
776	R:R:K223	R:R:L227	4.23	No	No	0	6	5
777	R:R:L225	R:R:L229	4.15	No	Yes	1	8	8
778	R:R:L229	R:R:L285	5.54	Yes	No	1	8	8
779	R:R:L229	R:R:Y286	4.69	Yes	Yes	1	8	9
780	R:R:I232	R:R:L285	4.28	No	No	0	7	8
781	R:R:F237	R:R:V233	3.93	Yes	No	0	8	9
782	R:R:C236	R:R:F237	4.19	No	Yes	31	8	8
783	R:R:C236	R:R:N278	4.72	No	No	31	8	9
784	R:R:F237	R:R:N278	13.29	Yes	No	31	8	9
785	R:R:L244	R:R:Y240	5.86	No	Yes	0	5	6
786	R:R:Y240	R:R:Y268	9.93	Yes	No	0	6	5
787	R:R:S271	R:R:Y240	5.09	No	Yes	0	7	6
788	R:R:L272	R:R:Y240	4.69	No	Yes	0	5	6
789	R:R:T275	R:R:Y240	3.75	No	Yes	0	8	6
790	R:R:L243	R:R:V264	4.47	Yes	No	0	4	4
791	R:R:L245	R:R:S248	4.5	No	No	0	6	5
792	R:R:R247	R:R:Y268	8.23	No	No	4	4	5
793	R:R:F260	R:R:I250	15.07	No	No	0	1	1
794	R:R:W256	R:R:Y251	16.4	No	No	0	3	3
795	R:R:D257	R:R:R254	4.76	No	No	0	5	2
796	R:R:P255	R:R:W256	4.05	No	No	0	2	3
797	R:R:C258	R:R:E261	6.08	No	No	4	8	4
798	R:R:F260	R:R:V264	6.55	No	No	0	1	4
799	R:R:F265	R:R:H269	11.31	Yes	Yes	4	4	5
800	R:R:F274	R:R:L277	3.65	No	No	0	7	5
801	R:R:D282	R:R:N278	14.81	No	No	0	9	9
802	R:R:G292	R:R:N290	5.09	No	Yes	0	6	8
803	R:R:A293	R:R:N290	4.69	No	Yes	0	8	8
804	R:R:E291	R:R:R294	11.63	No	No	0	5	8
805	B:B:S227	B:B:S245	3.26	No	No	2	6	9
806	A:A:A243	A:A:I288	3.25	No	Yes	0	8	9
807	B:B:A140	B:B:I120	3.25	No	No	0	5	6
808	B:B:D154	B:B:P107	3.22	No	No	0	6	6
809	R:R:A151	R:R:M181	3.22	No	No	0	7	4
810	R:R:V280	R:R:V30	3.21	Yes	No	0	8	6
811	R:R:V135	R:R:V54	3.21	No	No	29	4	7
812	A:A:S349	A:A:T350	3.2	No	No	0	7	4
813	B:B:S275	B:B:T274	3.2	No	No	0	8	8
814	R:R:R206	R:R:R209	3.2	No	No	0	3	4
815	B:B:G244	B:B:H225	3.18	No	Yes	0	5	9
816	R:R:C36	R:R:L37	3.17	No	No	0	3	7
817	R:R:T214	R:R:V208	3.17	No	No	0	3	8
818	B:B:L7	G:G:A12	3.15	Yes	No	0	8	5
819	R:R:A267	R:R:L243	3.15	No	Yes	0	5	4
820	G:G:E58	G:G:P55	3.14	No	No	0	5	5
821	B:B:A193	B:B:D195	3.09	No	No	0	4	5
822	B:B:I81	B:B:V71	3.07	Yes	No	0	7	8
823	R:R:I25	R:R:V74	3.07	No	No	0	4	7
824	A:A:K300	A:A:S306	3.06	No	No	0	9	7
825	G:G:K29	G:G:S31	3.06	No	No	0	4	9
826	A:A:K24	A:A:V20	3.04	No	No	0	4	3
827	A:A:M221	A:A:V57	3.04	Yes	No	0	8	7
828	A:A:I382	A:A:T242	3.04	Yes	No	0	6	8
829	A:A:K338	A:A:V334	3.04	Yes	No	0	5	4
830	B:B:M45	B:B:V296	3.04	No	Yes	0	4	5
831	B:B:A26	B:B:Q259	3.03	No	No	0	3	6
832	B:B:A28	B:B:Q32	3.03	No	No	0	4	1
833	A:A:M221	A:A:T210	3.01	Yes	No	0	8	7
834	B:B:T34	G:G:M38	3.01	No	No	0	5	4
835	B:B:G174	B:B:R137	3	No	No	0	4	5
836	R:R:L183	R:R:S248	3	No	No	0	4	5
837	R:R:L243	R:R:S271	3	Yes	No	0	4	7
838	A:A:L388	R:R:V119	2.98	No	No	0	8	8
839	B:B:L126	B:B:V112	2.98	No	No	0	5	8
840	B:B:L286	B:B:V296	2.98	No	Yes	0	7	5
841	R:R:L78	R:R:V74	2.98	No	No	0	5	7
842	R:R:L244	R:R:V186	2.98	No	No	0	5	5
843	R:R:L277	R:R:V280	2.98	No	Yes	0	5	8
844	A:A:V20	B:B:N88	2.96	No	Yes	0	3	7
845	A:A:V394	R:R:N290	2.96	No	Yes	0	8	8
846	B:B:L30	B:B:T34	2.95	Yes	No	0	5	5
847	B:B:L152	B:B:T196	2.95	Yes	No	0	3	1
848	G:G:L51	G:G:T52	2.95	Yes	No	0	6	4
849	R:R:L158	R:R:T166	2.95	No	No	0	5	3
850	B:B:I157	B:B:I171	2.94	No	No	0	7	6
851	A:A:I382	A:A:M386	2.92	Yes	No	0	6	3
852	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
853	R:R:G176	R:R:Y251	2.9	No	No	0	4	3
854	A:A:M221	A:A:M60	2.89	Yes	No	0	8	9
855	B:B:M217	G:G:M21	2.89	No	No	0	3	1
856	R:R:W40	R:R:Y43	2.89	No	No	0	4	4
857	A:A:V394	R:R:E218	2.85	No	No	0	8	5
858	B:B:I33	B:B:L30	2.85	No	Yes	0	3	5
859	B:B:I123	B:B:L139	2.85	No	Yes	0	6	9
860	R:R:E262	R:R:V11	2.85	No	No	0	3	3
861	R:R:I28	R:R:L32	2.85	Yes	No	28	7	6
862	R:R:I67	R:R:L32	2.85	No	No	28	6	6
863	R:R:E145	R:R:T144	2.82	No	No	0	7	5
864	A:A:K274	A:A:N271	2.8	No	No	0	5	5
865	B:B:K301	B:B:N35	2.8	Yes	No	0	5	1
866	B:B:K127	B:B:N125	2.8	No	Yes	0	4	4
867	G:G:D26	G:G:I28	2.8	No	No	0	1	4
868	A:A:A337	A:A:F315	2.77	No	Yes	0	8	6
869	B:B:L14	G:G:L19	2.77	No	Yes	0	8	9
870	B:B:L261	B:B:L30	2.77	Yes	Yes	0	5	5
871	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
872	B:B:L198	B:B:L210	2.77	No	No	0	3	5
873	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
874	B:B:A240	B:B:F235	2.77	No	Yes	0	6	6
875	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
876	G:G:L15	G:G:L19	2.77	No	Yes	0	2	9
877	R:R:L64	R:R:N35	2.75	No	Yes	0	8	9
878	B:B:I18	G:G:E22	2.73	No	Yes	0	7	9
879	A:A:K216	A:A:Q213	2.71	No	No	0	4	3
880	R:R:E218	R:R:K221	2.7	No	No	0	5	7
881	R:R:E291	R:R:K221	2.7	No	No	0	5	7
882	B:B:D153	B:B:N155	2.69	No	No	0	5	3
883	A:A:E299	A:A:L296	2.65	No	No	0	6	6
884	B:B:H266	B:B:I269	2.65	No	No	0	4	4
885	G:G:E22	G:G:L19	2.65	Yes	Yes	0	9	9
886	B:B:F335	B:B:S334	2.64	No	No	0	4	4
887	R:R:F260	R:R:S246	2.64	No	No	0	1	4
888	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
889	B:B:R214	B:B:V213	2.62	No	No	0	9	4
890	R:R:R49	R:R:V131	2.62	No	No	0	6	3
891	R:R:F274	R:R:V235	2.62	No	No	0	7	5
892	B:B:D5	B:B:Q6	2.61	No	No	0	1	1
893	B:B:D153	B:B:Q156	2.61	No	No	0	5	5
894	A:A:D229	A:A:E230	2.6	No	Yes	0	8	9
895	B:B:F180	B:B:T178	2.59	Yes	No	0	7	4
896	R:R:A62	R:R:W142	2.59	No	Yes	0	8	9
897	R:R:H302	R:R:L301	2.57	No	No	0	5	6
898	R:R:H79	R:R:N82	2.55	No	No	0	4	5
899	B:B:S147	B:B:Y145	2.54	No	Yes	0	9	8
900	R:R:V74	R:R:Y24	2.52	No	Yes	0	7	9
901	R:R:K221	R:R:R224	2.48	No	No	0	7	6
902	R:R:F187	R:R:L191	2.44	No	No	0	5	4
903	B:B:L7	G:G:R13	2.43	Yes	No	0	8	6
904	B:B:L192	B:B:R150	2.43	No	Yes	0	5	6
905	A:A:D223	A:A:F208	2.39	No	No	0	9	5
906	R:R:H17	R:R:H80	2.39	No	No	0	5	4
907	B:B:R256	G:G:D36	2.38	No	No	0	9	5
908	B:B:Q44	B:B:R46	2.34	No	No	0	4	5
909	A:A:N254	A:A:Y311	2.33	No	No	0	9	6
910	A:A:E314	A:A:F340	2.33	No	Yes	0	6	7
911	A:A:E390	A:A:Y391	2.24	No	Yes	0	4	4
912	A:A:F222	A:A:R42	2.14	No	No	0	7	9
913	B:B:G115	B:B:G116	2.11	No	No	0	9	9
914	A:A:G329	A:A:P328	2.03	No	No	0	7	1
915	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
916	B:B:C271	B:B:G272	1.96	Yes	No	0	5	4
917	R:R:C9	R:R:G8	1.96	Yes	No	0	8	5
918	A:A:A226	A:A:G206	1.95	No	No	0	9	8
919	A:A:A303	A:A:G304	1.95	No	No	0	5	5
920	B:B:A140	B:B:G141	1.95	No	No	0	5	5
921	R:R:A42	R:R:G53	1.95	No	No	0	7	7
922	R:R:A179	R:R:G176	1.95	No	No	0	1	4
923	B:B:A193	B:B:P194	1.87	No	No	0	4	4
924	R:R:A38	R:R:P283	1.87	No	No	0	9	9
925	R:R:A238	R:R:P239	1.87	No	No	0	5	9
926	A:A:G52	A:A:S51	1.86	No	Yes	0	9	9
927	R:R:G292	R:R:S295	1.86	No	No	0	6	4
928	B:B:G41	B:B:V40	1.84	No	No	0	1	3
929	B:B:G244	B:B:V276	1.84	No	No	0	5	6
930	R:R:G53	R:R:V46	1.84	No	No	0	7	6
931	B:B:G131	B:B:T128	1.82	No	No	0	4	3
932	R:R:A41	R:R:C287	1.81	No	No	0	7	7
933	R:R:A120	R:R:A207	1.79	No	No	0	7	5
934	R:R:P239	R:R:S271	1.78	No	No	0	9	7
935	G:G:P49	G:G:V54	1.77	No	No	0	7	6
936	R:R:G29	R:R:I28	1.76	No	Yes	0	5	7
937	A:A:P326	A:A:T325	1.75	No	No	0	1	2
938	B:B:P107	B:B:T65	1.75	No	No	0	6	1
939	G:G:P53	G:G:T52	1.75	No	No	0	8	4
940	B:B:G53	B:B:K89	1.74	No	Yes	0	9	9
941	B:B:G182	G:G:K14	1.74	No	No	0	6	4
942	R:R:G88	R:R:K91	1.74	No	No	0	2	6
943	A:A:A48	A:A:S51	1.71	No	Yes	0	8	9
944	B:B:C25	G:G:V30	1.71	No	No	0	3	8
945	R:R:A38	R:R:S60	1.71	No	No	0	9	8
946	B:B:A11	G:G:V16	1.7	No	No	0	5	7
947	B:B:A257	G:G:V30	1.7	No	No	0	7	8
948	B:B:D118	B:B:G116	1.68	No	No	0	9	9
949	R:R:L32	R:R:P33	1.64	No	No	0	6	5
950	A:A:I26	B:B:A92	1.62	No	No	0	9	6
951	B:B:A248	B:B:I269	1.62	No	No	0	5	4
952	R:R:S139	R:R:V135	1.62	No	No	0	5	4
953	R:R:A281	R:R:I232	1.62	No	No	0	7	7
954	B:B:D38	B:B:P39	1.61	No	No	0	1	1
955	R:R:A42	R:R:M57	1.61	No	No	0	7	5
956	A:A:S366	A:A:T55	1.6	No	No	0	9	9
957	B:B:S207	B:B:T223	1.6	No	No	0	5	2
958	R:R:V131	R:R:V54	1.6	No	No	29	3	7
959	R:R:V131	R:R:V135	1.6	No	No	29	3	4
960	B:B:L300	G:G:C41	1.59	No	No	0	6	7
961	B:B:G310	B:B:H311	1.59	No	Yes	0	5	9
962	R:R:T133	R:R:V137	1.59	No	No	0	3	5
963	R:R:T144	R:R:V140	1.59	No	No	0	5	3
964	R:R:C287	R:R:L288	1.59	No	No	0	7	7
965	B:B:A11	G:G:L19	1.58	No	Yes	0	5	9
966	B:B:L30	G:G:A34	1.58	Yes	No	0	5	6
967	G:G:A45	G:G:L51	1.58	No	Yes	0	4	6
968	A:A:E327	A:A:P328	1.57	No	No	0	4	1
969	A:A:A19	B:B:N88	1.56	No	Yes	0	4	7
970	B:B:A309	B:B:N293	1.56	No	No	0	3	5
971	B:B:D254	G:G:A33	1.54	No	No	0	9	7
972	R:R:I284	R:R:V280	1.54	No	Yes	0	7	8
973	R:R:I284	R:R:V289	1.54	No	No	0	7	6
974	R:R:A300	R:R:D296	1.54	No	No	0	3	4
975	B:B:M262	B:B:S31	1.53	No	No	0	4	1
976	B:B:K280	B:B:S279	1.53	No	No	0	1	9
977	A:A:A14	A:A:E15	1.51	No	No	0	1	6
978	A:A:A316	A:A:E309	1.51	No	No	0	2	4
979	G:G:A39	G:G:E42	1.51	No	No	0	3	1
980	R:R:L153	R:R:S150	1.5	No	No	0	4	4
981	R:R:G210	R:R:R209	1.5	No	No	0	4	4
982	R:R:L225	R:R:S228	1.5	No	No	1	8	6
983	R:R:L229	R:R:S228	1.5	Yes	No	1	8	6
984	R:R:L285	R:R:S228	1.5	No	No	1	8	6
985	R:R:G253	R:R:R254	1.5	No	No	0	3	2
986	B:B:N125	B:B:S136	1.49	Yes	No	0	4	4
987	R:R:L243	R:R:V242	1.49	Yes	No	0	4	6
988	B:B:D322	B:B:S67	1.47	No	No	0	1	5
989	A:A:T204	B:B:N119	1.46	No	Yes	0	9	9
990	B:B:N125	B:B:T128	1.46	Yes	No	0	4	3
991	R:R:I61	R:R:M57	1.46	No	No	0	5	5
992	R:R:A298	R:R:H302	1.46	No	No	0	4	5
993	G:G:I28	G:G:K32	1.45	No	No	0	4	5
994	A:A:F312	A:A:P313	1.44	Yes	No	0	8	6
995	A:A:P313	A:A:R317	1.44	No	No	0	6	2
996	R:R:P255	R:R:R254	1.44	No	No	0	2	2
997	A:A:Q35	A:A:V36	1.43	No	No	0	3	2
998	R:R:I61	R:R:L65	1.43	No	No	0	5	7
999	A:A:Q59	A:A:T55	1.42	No	No	0	9	9
1000	B:B:K15	G:G:L19	1.41	No	Yes	0	6	9
1001	G:G:M21	G:G:N24	1.4	No	No	0	1	1
1002	A:A:D33	A:A:K32	1.38	No	No	0	5	4
1003	B:B:A21	G:G:R27	1.38	No	No	0	4	8
1004	B:B:L261	G:G:L37	1.38	Yes	No	0	5	7
1005	R:R:D296	R:R:K299	1.38	No	No	0	4	5
1006	R:R:D75	R:R:L78	1.36	No	No	0	4	5
1007	B:B:L14	B:B:Q13	1.33	No	No	0	8	1
1008	R:R:A148	R:R:Y184	1.33	No	No	0	5	3
1009	R:R:R263	R:R:V264	1.31	No	No	0	3	4
1010	A:A:R283	A:A:T284	1.29	No	No	0	3	4
1011	R:R:E215	R:R:E218	1.27	No	No	0	3	5
1012	B:B:D267	B:B:H266	1.26	No	No	0	3	4
1013	A:A:K34	A:A:R38	1.24	No	No	0	4	4
1014	A:A:N377	A:A:R373	1.21	No	No	0	4	5
1015	B:B:N132	B:B:R134	1.21	No	No	0	3	3
1016	A:A:D49	A:A:R265	1.19	No	Yes	0	7	9
1017	A:A:Q35	A:A:R39	1.17	No	No	0	3	9
1018	R:R:Q48	R:R:R44	1.17	No	No	0	7	4
1019	B:B:N125	B:B:Y111	1.16	Yes	No	0	4	4
1020	R:R:H17	R:R:R14	1.13	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:S51	3.65	5	17	9
2	A:A:F219	7.30167	6	0	8
3	A:A:M221	4.355	4	0	8
4	A:A:E230	6.895	4	2	9
5	A:A:R231	6.735	4	16	9
6	A:A:R232	8.12	4	2	8
7	A:A:K233	5.71	6	2	9
8	A:A:W234	5.31	4	0	9
9	A:A:F238	10.3875	4	0	9
10	A:A:D249	8.62	4	11	8
11	A:A:Y253	6.9275	4	0	8
12	A:A:R265	8.3	4	11	9
13	A:A:W277	13.9175	4	0	6
14	A:A:W281	9.895	6	3	5
15	A:A:I288	7.4225	4	5	9
16	A:A:F290	5.53	6	5	9
17	A:A:N292	5.242	5	0	9
18	A:A:F312	3.8225	4	0	8
19	A:A:F315	9.832	5	0	6
20	A:A:Y318	6.3975	4	12	6
21	A:A:K338	6.8775	4	0	5
22	A:A:Y339	5.916	5	19	3
23	A:A:F340	6.69333	6	12	7
24	A:A:K343	6.84	4	12	3
25	A:A:F345	10.515	4	0	8
26	A:A:Y360	6.80429	7	5	8
27	A:A:F363	7.495	4	19	5
28	A:A:T364	8.5575	4	5	9
29	A:A:R374	8.7525	4	5	4
30	A:A:F376	4.99	6	1	8
31	A:A:D381	5.65	4	5	8
32	A:A:I382	4.2475	4	5	6
33	A:A:I383	4.05	4	1	8
34	A:A:Y391	5.96429	7	1	4
35	B:B:L7	3.87	4	0	8
36	B:B:L30	2.5375	4	0	5
37	B:B:L51	6.4175	4	0	9
38	B:B:H54	9.786	5	7	9
39	B:B:K57	10.41	5	3	9
40	B:B:I58	7.2075	4	7	9
41	B:B:Y59	7.3625	4	3	8
42	B:B:W63	8.6975	4	0	7
43	B:B:L69	4.9275	4	10	5
44	B:B:S72	5.3725	4	7	9
45	B:B:Q75	8.77	4	3	9
46	B:B:I81	4.2	5	10	7
47	B:B:W82	8.94667	6	7	9
48	B:B:N88	5.93	4	0	7
49	B:B:K89	5.9	5	7	9
50	B:B:I93	4.7175	4	0	7
51	B:B:L95	5.6475	4	0	8
52	B:B:W99	9.7	5	0	9
53	B:B:Y105	4.052	5	10	6
54	B:B:N119	3.475	4	0	9
55	B:B:Y124	5.78	5	0	6
56	B:B:N125	1.7275	4	0	4
57	B:B:L139	6.0575	4	0	9
58	B:B:H142	8.798	5	8	9
59	B:B:Y145	5.33667	6	2	8
60	B:B:R150	9.0275	4	0	6
61	B:B:F151	5.285	4	0	9
62	B:B:L152	4.5825	4	0	3
63	B:B:D163	8.3975	4	8	9
64	B:B:L168	5.7325	4	0	6
65	B:B:W169	10.174	5	8	8
66	B:B:F180	8.4825	4	6	7
67	B:B:H183	8.068	5	6	9
68	B:B:F199	7.575	4	6	9
69	B:B:V200	7.015	4	2	6
70	B:B:C204	6.475	4	2	7
71	B:B:D205	7.025	4	6	9
72	B:B:K209	9.7625	4	6	6
73	B:B:W211	9.346	5	6	8
74	B:B:F222	7.428	5	2	8
75	B:B:H225	8.77167	6	2	9
76	B:B:D228	7.608	5	2	9
77	B:B:I232	5.8625	4	2	8
78	B:B:F234	6.2475	4	0	5
79	B:B:F235	6.225	4	13	6
80	B:B:F241	7.32333	6	2	6
81	B:B:D246	7.5475	4	2	9
82	B:B:D247	9.075	4	2	9
83	B:B:R251	12.035	4	2	8
84	B:B:F253	8.685	4	2	6
85	B:B:L261	5.1475	4	0	5
86	B:B:Y264	4.95	5	0	5
87	B:B:C271	4.22	4	3	5
88	B:B:S277	4.125	4	25	5
89	B:B:F278	5.496	5	13	7
90	B:B:R283	7.854	5	20	9
91	B:B:Y289	6.29857	7	3	7
92	B:B:D290	9.035	4	3	6
93	B:B:N295	6.05	4	3	6
94	B:B:V296	3.512	5	0	5
95	B:B:K301	7.07	4	0	5
96	B:B:H311	5.22667	6	27	9
97	B:B:R314	12.138	5	3	8
98	B:B:L318	5.6975	4	25	6
99	B:B:W332	11.3029	7	3	9
100	B:B:D333	7.106	5	27	9
101	B:B:L336	6.6775	4	7	7
102	B:B:W339	9.11	4	0	9
103	G:G:L19	2.236	5	0	9
104	G:G:E22	4.385	4	0	9
105	G:G:D48	6.65	5	26	9
106	G:G:L51	3.4	4	0	6
107	G:G:N59	7.335	4	21	9
108	G:G:F61	8.658	5	21	8
109	R:R:C9	5.065	4	4	8
110	R:R:D16	6.1	4	4	5
111	R:R:Y24	5.938	5	0	9
112	R:R:I28	3.92	5	28	7
113	R:R:N35	5.255	4	0	9
114	R:R:L52	4.566	5	1	8
115	R:R:Y55	5.512	5	0	7
116	R:R:L56	4.426	5	1	8
117	R:R:Y66	7.934	5	0	7
118	R:R:Y76	5.97	4	4	6
119	R:R:F77	8.3025	4	4	5
120	R:R:W83	7.452	5	0	9
121	R:R:F95	8.6725	4	9	6
122	R:R:I96	4.5725	4	0	5
123	R:R:F97	7.8625	4	0	7
124	R:R:F107	7.5775	4	9	8
125	R:R:I111	4.408	5	1	9
126	R:R:D114	6.375	4	1	8
127	R:R:Y116	9.376	5	1	8
128	R:R:P122	3.7375	4	1	7
129	R:R:L123	4.546	5	1	6
130	R:R:F125	6.6425	4	0	6
131	R:R:R129	6.3525	4	1	7
132	R:R:W142	5.094	5	9	9
133	R:R:E157	7.7725	4	14	5
134	R:R:Y163	12.6575	4	4	3
135	R:R:H165	6.5575	4	4	1
136	R:R:F167	6.104	5	4	4
137	R:R:F172	7.842	5	4	5
138	R:R:W177	15.7125	4	0	1
139	R:R:R185	7.13	4	0	5
140	R:R:P193	4.6175	4	30	9
141	R:R:Y201	6.015	6	1	8
142	R:R:S213	7.895	4	5	3
143	R:R:L229	5.052	5	1	8
144	R:R:I230	4.91	4	1	7
145	R:R:F237	7.326	5	31	8
146	R:R:Y240	5.864	5	0	6
147	R:R:L243	3.0275	4	0	4
148	R:R:F265	11.058	5	4	4
149	R:R:H269	6.6325	4	4	5
150	R:R:S276	5.3725	4	0	7
151	R:R:V280	3.135	4	0	8
152	R:R:Y286	5.6075	4	1	9
153	R:R:N290	6.93	4	0	8
154	W:W:?1	8.635	8	30	0
155	W:W:?2	9.49143	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:L70	B:B:W82	47.6184	5.69	No	Yes	0	5	9
2	B:B:L70	B:B:W63	47.4066	12.53	No	Yes	0	5	7
3	B:B:S84	B:B:W63	35.8671	4.94	No	Yes	0	5	7
4	B:B:S84	B:B:Y85	35.6514	3.82	No	No	0	5	4
5	B:B:R68	B:B:Y85	35.5079	17.49	No	No	0	5	4
6	B:B:D83	B:B:R68	18.3159	16.68	No	No	0	8	5
7	B:B:I93	B:B:P94	10.7502	3.39	Yes	No	0	7	5
8	B:B:L95	B:B:V100	13.879	4.47	Yes	No	0	8	9
9	B:B:A73	B:B:V100	27.7554	3.39	No	No	0	9	9
10	B:B:A73	B:B:C103	28.2005	3.61	No	No	0	9	8
11	B:B:C103	B:B:V71	29.0904	6.83	No	No	0	8	8
12	B:B:I81	B:B:V71	29.5352	3.07	Yes	No	0	7	8
13	B:B:I81	B:B:L69	30.8494	5.71	Yes	Yes	10	7	5
14	B:B:D66	B:B:L69	16.7554	4.07	No	Yes	0	8	5
15	B:B:D66	B:B:R68	16.9757	4.76	No	No	0	8	5
16	B:B:C114	B:B:V100	13.4313	3.42	No	No	0	8	9
17	B:B:D83	B:B:L69	16.7739	4.07	No	Yes	0	8	5
18	B:B:H54	B:B:I58	26.0155	7.95	Yes	Yes	7	9	9
19	B:B:C317	B:B:I58	52.2297	3.27	No	Yes	0	7	9
20	B:B:C317	B:B:S316	52.4098	3.44	No	No	0	7	9
21	B:B:S316	B:B:W332	52.4998	4.94	No	Yes	0	9	9
22	B:B:K57	B:B:W332	50.1044	19.73	Yes	Yes	3	9	9
23	B:B:K57	B:B:Q75	50.0971	12.2	Yes	Yes	3	9	9
24	B:B:Q75	B:B:W99	100	4.38	Yes	Yes	0	9	9
25	A:A:F238	B:B:W99	98.8814	14.03	Yes	Yes	0	9	9
26	A:A:F238	A:A:W234	98.2578	4.01	Yes	Yes	0	9	9
27	A:A:R231	A:A:W234	98.0147	4	Yes	Yes	0	9	9
28	A:A:D272	A:A:R231	97.9562	14.29	No	Yes	16	8	9
29	A:A:D272	A:A:F246	97.9095	7.17	No	No	0	8	9
30	A:A:F246	A:A:G47	89.8886	4.52	No	No	0	9	9
31	A:A:G47	A:A:S51	89.1991	3.71	No	Yes	17	9	9
32	A:A:S51	A:A:V247	89.0825	4.85	Yes	No	0	9	7
33	A:A:N292	A:A:V247	88.9925	4.43	Yes	No	0	9	7
34	A:A:N292	A:A:T364	86.8084	4.39	Yes	Yes	0	9	9
35	A:A:F290	A:A:T364	86.3181	9.08	Yes	Yes	5	9	9
36	A:A:F290	A:A:I245	83.5102	3.77	Yes	No	5	9	7
37	A:A:I245	A:A:L43	84.1417	5.71	No	No	0	7	7
38	A:A:F219	A:A:L43	84.0457	4.87	Yes	No	0	8	7
39	A:A:F219	A:A:L41	78.1827	7.31	Yes	No	0	8	7
40	A:A:I383	A:A:L41	78.0839	4.28	Yes	No	0	8	7
41	A:A:I383	A:A:N387	75.2671	4.25	Yes	No	1	8	8
42	A:A:N387	A:A:Y391	74.9148	8.14	No	Yes	1	8	4
43	A:A:Y391	R:R:D114	15.2721	3.45	Yes	Yes	1	4	8
44	R:R:D114	R:R:Y55	15.2112	6.9	Yes	Yes	0	8	7
45	B:B:H54	B:B:W82	24.5461	9.52	Yes	Yes	7	9	9
46	B:B:S72	B:B:W82	24.5063	3.71	Yes	Yes	7	9	9
47	B:B:I58	B:B:S72	24.5879	6.19	Yes	Yes	7	9	9
48	B:B:W332	B:B:Y59	50.1045	8.68	Yes	Yes	3	9	8
49	B:B:Q75	B:B:Y59	50.0613	12.4	Yes	Yes	3	9	8
50	A:A:W281	B:B:W332	40.8596	10.31	Yes	Yes	3	5	9
51	A:A:W281	B:B:D290	40.2649	7.82	Yes	Yes	3	5	6
52	B:B:C271	B:B:D290	80.5134	4.67	Yes	Yes	3	5	6
53	B:B:C271	B:B:Y289	79.6167	4.03	Yes	Yes	3	5	7
54	B:B:I273	B:B:Y289	75.1867	6.04	No	Yes	0	6	7
55	B:B:G244	B:B:I273	75.076	5.29	No	No	0	5	6
56	B:B:G244	B:B:H225	74.562	3.18	No	Yes	0	5	9
57	B:B:H225	B:B:S245	22.1254	12.55	Yes	No	2	9	9
58	B:B:S227	B:B:S245	21.9487	3.26	No	No	2	6	9
59	B:B:D228	B:B:S227	11.5752	4.42	Yes	No	2	9	6
60	A:A:K233	B:B:Y145	18.7743	3.58	Yes	Yes	2	9	8
61	B:B:R314	B:B:W332	41.6935	13.99	Yes	Yes	3	8	9
62	B:B:D290	B:B:R314	40.154	17.87	Yes	Yes	3	6	8
63	B:B:D246	B:B:S227	10.1784	5.89	Yes	No	2	9	6
64	A:A:F246	A:A:V248	13.6711	3.93	No	No	0	9	7
65	A:A:F345	A:A:V248	13.3846	6.55	Yes	No	0	8	7
66	A:A:F345	A:A:L289	10.066	17.05	Yes	No	0	8	9
67	A:A:Y391	R:R:L52	59.2563	3.52	Yes	Yes	1	4	8
68	R:R:I111	R:R:L52	29.1646	4.28	Yes	Yes	1	9	8
69	B:B:H225	B:B:T243	50.6503	10.95	Yes	No	2	9	8
70	B:B:I232	B:B:T243	24.2712	4.56	Yes	No	2	8	8
71	B:B:I232	B:B:V200	23.8959	7.68	Yes	Yes	2	8	6
72	B:B:F234	B:B:V200	44.3938	9.18	Yes	Yes	0	5	6
73	B:B:A193	B:B:F234	43.7424	5.55	No	Yes	0	4	5
74	B:B:A193	B:B:D195	42.5947	3.09	No	No	0	4	5
75	B:B:D195	B:B:R197	42.2119	8.34	No	No	0	5	5
76	B:B:R197	B:B:R214	41.8291	9.6	No	No	0	5	9
77	B:B:R214	B:B:V213	41.4462	2.62	No	No	0	9	4
78	B:B:F199	B:B:V213	41.0632	2.62	Yes	No	0	9	4
79	B:B:F199	B:B:W211	25.1855	11.02	Yes	Yes	6	9	8
80	B:B:K209	B:B:W211	12.0635	9.28	Yes	Yes	6	6	8
81	G:G:E22	G:G:L19	10.9092	2.65	Yes	Yes	0	9	9
82	B:B:F241	B:B:T243	26.1972	5.19	Yes	No	2	6	8
83	B:B:F241	B:B:V200	23.9267	5.24	Yes	Yes	2	6	6
84	B:B:T321	B:B:W63	11.8394	12.13	No	Yes	0	7	7
85	B:B:D323	B:B:T321	11.3881	7.23	No	No	0	7	7
86	B:B:D323	B:B:M325	10.7106	8.32	No	No	0	7	5
87	B:B:M325	G:G:P49	10.4846	6.71	No	No	0	5	7
88	B:B:F180	B:B:F199	14.339	11.79	Yes	Yes	6	7	9
89	B:B:F180	B:B:T178	13.6647	2.59	Yes	No	0	7	4
90	B:B:L168	B:B:T178	13.2757	4.42	Yes	No	0	6	4
91	B:B:G162	B:B:Y145	14.8024	8.69	No	Yes	0	9	8
92	B:B:G162	B:B:S161	14.4039	3.71	No	No	0	9	9
93	B:B:H142	B:B:S161	11.6043	15.34	Yes	No	8	9	9
94	R:R:L52	R:R:L56	28.079	6.92	Yes	Yes	1	8	8
95	R:R:L56	R:R:Y286	27.4377	3.52	Yes	Yes	1	8	9
96	R:R:L108	R:R:Y286	53.2218	9.38	No	Yes	0	8	9
97	R:R:L108	R:R:L59	48.9784	4.15	No	No	0	8	9
98	R:R:D63	R:R:L59	48.4841	4.07	No	No	0	9	9
99	R:R:C279	R:R:D63	45.5139	7.78	No	No	0	9	9
100	R:R:C279	R:R:Y66	43.7418	4.03	No	Yes	0	9	7
101	R:R:L70	R:R:Y66	11.2525	8.21	No	Yes	0	8	7
102	R:R:L70	R:R:Y24	10.9974	10.55	No	Yes	0	8	9
103	R:R:F77	R:R:Y24	18.9197	6.19	Yes	Yes	0	5	9
104	R:R:F77	R:R:H269	17.3958	6.79	Yes	Yes	4	5	5
105	R:R:I111	R:R:Y286	27.3758	4.84	Yes	Yes	1	9	9
106	R:R:S276	R:R:Y66	14.6006	3.82	Yes	Yes	0	7	7
107	R:R:S276	R:R:Y24	11.0087	5.09	Yes	Yes	0	7	9
108	R:R:F97	R:R:Y66	17.0754	15.47	Yes	Yes	0	7	7
109	R:R:F97	R:R:L272	11.7541	4.87	Yes	No	0	7	5
110	R:R:L272	R:R:Y240	11.4983	4.69	No	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C109	R:R:L196	4.76	0	No	No	8	6	2	1
R:R:S112	R:R:S200	6.52	1	No	No	9	8	2	1
R:R:A120	R:R:Y116	5.34	1	No	Yes	7	8	2	1
R:R:H121	R:R:Y116	5.44	1	No	Yes	6	8	2	1
R:R:S200	R:R:Y116	3.82	1	No	Yes	8	8	1	1
R:R:I204	R:R:Y116	3.63	0	No	Yes	8	8	2	1
R:R:Y116	W:W:?2	28.65	1	Yes	Yes	8	0	1	0
R:R:A120	R:R:H121	4.39	1	No	No	7	6	2	2
R:R:F192	R:R:L196	12.18	30	No	No	5	6	2	1
R:R:L196	W:W:?2	4.41	0	No	Yes	6	0	1	0
R:R:L199	W:W:?2	7.35	0	No	Yes	5	0	1	0
R:R:S200	W:W:?2	6.38	1	No	Yes	8	0	1	0
R:R:R202	R:R:R206	4.26	1	No	No	3	3	1	1
R:R:R202	W:W:?2	9.04	1	No	Yes	3	0	1	0
R:R:G203	W:W:?2	5.45	0	No	Yes	4	0	1	0
R:R:R206	W:W:?2	5.16	1	No	Yes	3	0	1	0
R:R:R206	R:R:R209	3.2	1	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
66.67	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
50.00	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
20.00	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
10.00	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
8.33	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.69	Single	6OBA	GTPL11074	6OBA-β₂-S-Alprenolol-GTPL11074
7.14	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
6.67	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
6.67	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
6.67	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
6.25	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
5.56	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
5.56	Single	9CM7	AZ-1729	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
5.00	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
4.55	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
4.17	Single	5KW2	PubChem 133053953	5KW2-FFA1-PubChem 133053953

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C110	R:R:Y55	5.38	0	No	Yes	7	7	1	2
R:R:V137	R:R:Y55	6.31	0	No	Yes	5	7	1	2
R:R:E145	R:R:I103	5.47	0	No	No	7	7	1	2
R:R:I105	R:R:P193	3.39	0	No	Yes	8	9	2	1
R:R:A106	W:W:?1	6.7	0	No	Yes	6	0	1	0
R:R:C109	R:R:P193	3.77	0	No	Yes	8	9	2	1
R:R:C109	R:R:L196	4.76	0	No	No	8	6	2	2
R:R:C110	W:W:?1	10.12	0	No	Yes	7	0	1	0
R:R:V113	W:W:?1	9.5	0	No	Yes	6	0	1	0
R:R:V137	W:W:?1	6.33	0	No	Yes	5	0	1	0
R:R:E145	W:W:?1	18.3	0	No	Yes	7	0	1	0
R:R:G189	R:R:V188	3.68	0	No	No	6	4	1	2
R:R:G189	W:W:?1	7.27	0	No	Yes	6	0	1	0
R:R:F192	R:R:P193	4.33	30	No	Yes	5	9	1	1
R:R:F192	R:R:L196	12.18	30	No	No	5	6	1	2
R:R:F192	W:W:?1	3.88	30	No	Yes	5	0	1	0
R:R:P193	W:W:?1	6.98	30	Yes	Yes	9	0	1	0
R:R:E145	R:R:T144	2.82	0	No	No	7	5	1	2
R:R:T133	R:R:V137	1.59	0	No	No	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
70.00	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
50.00	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
45.45	Single	8K9L	BMS-986122	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
41.67	Single	8Y72	BMS-986122	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
38.46	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
36.36	Single	6OBA	GTPL11074	6OBA-β₂-S-Alprenolol-GTPL11074
35.71	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
30.77	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
30.77	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
30.00	Single	5KW2	PubChem 133053953	5KW2-FFA1-PubChem 133053953
30.00	Single	5XSZ	Glyceryl-mono-oleate	5XSZ-LPA₆-Glyceryl-mono-oleate
25.00	Single	9CM7	AZ-1729	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
23.53	Single	8XXV	A1D5Q	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
23.08	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
17.65	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
17.65	Single	9IYB	A1D5Q	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
14.29	Single	9CM3	Compound 187	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Single	9K1C	DHA	9K1C-FFA1-DHA-Gi1/β1/γ2
13.33	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
13.33	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
12.50	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
12.50	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
12.50	Single	8IYX	YL-365	8IYX-GPR34-YL-365
11.11	Single	8YYX	Leukotriene e4	8YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
10.53	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/β1/γ2
10.53	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
10.00	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.52	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	9NS9	Compound 187	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
7.41	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.41	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.14	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8XXU	A1D5Q	8XXU-DP₂-A1D5Q-Gi1/β1/γ2
6.90	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.67	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
6.67	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.67	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2
6.67	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
6.67	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
6.67	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
6.67	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
6.67	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.67	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
6.67	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
6.67	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go/β1/γ2
6.67	Single	9AS2	DMT	9AS2-5-HT_2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	9AS7	Psilocin	9AS7-5-HT_2A-Psilocin
6.67	Single	9IJE	Epinephrine	9IJE-β₃-Epinephrine-chim(NtGi1-Gs)/β1/γ2
6.67	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
6.67	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.25	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
6.25	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
6.25	Single	7LJC	Mevidalen	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
6.25	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
6.25	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
6.25	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
6.25	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
6.25	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
6.25	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
6.25	Single	8TZQ	L-Dopamine	8TZQ-D₂-L-Dopamine-Go/β1/γ2
6.25	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
6.25	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
6.25	Single	9LRB	Histamine	9LRB-H₁-Histamine-Gs/β1/γ2
6.25	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
6.25	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.25	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.25	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
6.25	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.88	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
5.88	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
5.88	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.88	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
5.88	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
5.88	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.88	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
5.88	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
5.88	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.88	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.88	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.88	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
5.88	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
5.88	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
5.88	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
5.88	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
5.88	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
5.88	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
5.88	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.88	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
5.88	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
5.88	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
5.88	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
5.88	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
5.88	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
5.88	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
5.88	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
5.88	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
5.88	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
5.88	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.88	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.88	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
5.88	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
5.88	Single	9ARX	Serotonin	9ARX-5-HT_2A-Serotonin
5.88	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
5.88	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
5.88	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
5.88	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
5.88	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
5.88	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
5.88	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.88	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.88	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.56	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.56	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.56	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.56	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
5.56	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
5.56	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
5.56	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
5.56	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
5.56	Single	4QKX	35V	4QKX-β₂-35V
5.56	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
5.56	Single	4U16	N-Methyl-Scopolamine	4U16-M₃-N-Methyl-Scopolamine
5.56	Single	5DHG	C-35	5DHG-NOP-C-35
5.56	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
5.56	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
5.56	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
5.56	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
5.56	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.56	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
5.56	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
5.56	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.56	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
5.56	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
5.56	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
5.56	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.56	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.56	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
5.56	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.56	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
5.56	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
5.56	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
5.56	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.56	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.56	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
5.56	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.56	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
5.56	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
5.56	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
5.56	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
5.56	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
5.56	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
5.56	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
5.56	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
5.56	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.56	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.56	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
5.56	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
5.56	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
5.56	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
5.56	Single	9AS1	DMT	9AS1-5-HT_2A-DMT
5.56	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
5.56	Single	9JEA	Atropine	9JEA-M₁-Atropine
5.56	Single	9PLN	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	9PLN-α_2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
5.56	Single	9PLO	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	9PLO-α_2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
5.56	Single	9PQD	(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole	9PQD-α_2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
5.56	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.56	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.56	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.56	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.56	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.56	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.56	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
5.56	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
5.56	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
5.56	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
5.56	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
5.56	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
5.56	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.56	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
5.56	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.56	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
5.56	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
5.56	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56	Consensus	histamine_off	Orthosteric Ligand	h1_off
5.56	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
5.56	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
5.56	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
5.26	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
5.26	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
5.26	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
5.26	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
5.26	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
5.26	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.26	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
5.26	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
5.26	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
5.26	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
5.26	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
5.26	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.26	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.26	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.26	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
5.26	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
5.26	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.26	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
5.26	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	9ARY	Serotonin	9ARY-5-HT_2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
5.26	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-Go/β1/γ2
5.26	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-Gi1/β1/γ2
5.26	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
5.26	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
5.26	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.26	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.26	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.26	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
5.26	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
5.26	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
5.26	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
5.26	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.26	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
5.26	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
5.26	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.26	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
5.26	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
5.26	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.26	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
5.26	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.26	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.26	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
5.26	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
5.26	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
5.00	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.00	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.00	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
5.00	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.00	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.00	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
5.00	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
5.00	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
5.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.00	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
5.00	Single	6E59	L-760735	6E59-NK₁-L-760735
5.00	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
5.00	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
5.00	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
5.00	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
5.00	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
5.00	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
5.00	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
5.00	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
5.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
5.00	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
5.00	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
5.00	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.00	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.00	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
5.00	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
5.00	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
5.00	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
5.00	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
5.00	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.00	Single	9AS9	RS130-180	9AS9-5-HT_2A-RS130-180
5.00	Single	9ASA	RS130-180	9ASA-5-HT_2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9I54	A1IZV	9I54-D₁-A1IZV-Gs/β1/γ2
5.00	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.00	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.00	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
5.00	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
5.00	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.00	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.00	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
5.00	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
5.00	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.00	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
5.00	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
5.00	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
5.00	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.00	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
4.76	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.76	Single	3D4S	Timolol	3D4S-β₂-Timolol
4.76	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.76	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.76	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
4.76	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.76	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.76	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
4.76	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
4.76	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.76	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.76	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
4.76	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.76	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
4.76	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
4.76	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
4.76	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.76	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.76	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.76	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
4.76	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
4.76	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.76	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.76	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
4.76	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
4.76	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.76	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.76	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
4.76	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
4.76	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.76	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.76	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.76	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
4.76	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.76	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
4.76	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
4.76	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.76	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.76	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.55	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.55	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.55	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.55	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.55	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.55	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.55	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
4.55	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.55	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.55	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.55	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.55	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.55	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.55	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.55	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-Go/β1/γ2
4.55	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.55	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
4.35	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
4.35	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
4.35	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.35	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.35	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-Gz/β1/γ2
4.35	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
4.17	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.17	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
4.17	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.17	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
4.17	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.17	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
4.17	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.17	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
4.17	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
4.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.00	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
3.85	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.85	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.85	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.70	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.70	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
3.70	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
3.57	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
3.57	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.45	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
3.45	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.45	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
3.33	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
3.33	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
3.23	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.23	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
3.12	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.12	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
3.12	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
2.86	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2

PDB Summary
PDB	9JCP
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR4
Species	Homo sapiens
Ligand	-
Other Ligand(s)	LPC
Protein Partners	chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution	2.55
Date	2025-07-09
D.O.I.	doi.org/10.1038/s41421-025-00807-y

Net Summary
I_min	3.27
Number of Linked Nodes	872
Number of Links	1020
Number of Hubs	155
Number of Links mediated by Hubs	585
Number of Communities	31
Number of Nodes involved in Communities	211
Number of Links involved in Communities	285

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	3244114
Length Of Smallest Path	3
Average Path Length	41.9854
Length of Longest Path	70
Minimum Path Strength	1.3
Average Path Strength	6.62138
Maximum Path Strength	23.275
Minimum Path Correlation	0.7
Average Path Correlation	0.990203
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.78571
Average % Of Corr. Nodes	36.7165
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.5189
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell adhesion • regulation of cell adhesion • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cell communication • small GTPase-mediated signal transduction • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • Rho protein signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • regulation of vascular permeability • multicellular organismal process • system process • circulatory system process • vascular process in circulatory system • regulation of biological quality • blood circulation • cellular developmental process • connective tissue development • mesangial cell development • cell development • epithelial cell differentiation • renal system development • kidney vasculature development • multicellular organism development • pericyte cell differentiation • renal system vasculature development • mesangial cell differentiation • cell differentiation • anatomical structure development • nephron development • system development • epithelial cell differentiation involved in kidney development • blood vessel development • developmental process • epithelium development • animal organ development • tissue development • glomerular mesangium development • glomerular mesangial cell development • vasculature development • glomerular mesangial cell differentiation • circulatory system development • glomerulus development • epithelial cell development • cell differentiation involved in kidney development • glomerulus vasculature development • kidney development • regulation of developmental process • negative regulation of biological process • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • anatomical structure morphogenesis • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of multicellular organismal process • response to pH • response to abiotic stimulus • response to acidic pH • wound healing • angiogenesis involved in wound healing • response to wounding
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_W_
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>9JCP_Chain_A E K A E K I E K Q L Q K D K Q V Y R T R L L L L G A S G K S T I V K Q M R I H V V T S G I F E T K F Q V D K V N F H M F D V G Q R D E R R K W I Q C F N D V T A I I F V V S S Y N R L Q E A L N F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R E F I S T A S G D G R H C Y P H F T C V D T E N R R F N D C D I I M L R Y L T L S A D A V R S M R L D N Y K A D D D K V D I S A I K L Q N E N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>9JCP_Chain_B D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>9JCP_Chain_G A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46093
Sequence	>9JCP_Chain_R G C H V D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q R N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H D N W I H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H P L R F A R L R R V K T A V A V S S V V W A T E L G A N S A P L F H D E L F R D R Y N H T F C F E K F P M E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G S V S T E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P W D C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G A R S D V A K A L H N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JCP	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZCE	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCE (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFU	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	3.23	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8Z3M	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-04-23	To be published
	8Z3M (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	To be published
	8Z3Q	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-04-23	To be published
	8Z3Q (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.76	2025-04-23	To be published
	8Z65	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-04-23	To be published
	8Z65 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.98	2025-04-23	To be published
	8Z66	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.06	2025-04-23	To be published
	8Z67	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-04-23	To be published
	9LMO	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-07-09	To be published
	9LMP	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	2.65	2025-07-02	To be published
	8Z3Y	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2025-06-04	To be published
	8Z3Y (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.2	2025-06-04	To be published
	8Z9P	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gi1/β1/γ2	2.5	2025-07-09	To be published
	8Z9P (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.5	2025-07-09	To be published
	9IV6	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-07-30	To be published
	9IV6 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.71	2025-07-30	To be published
	8Z9O	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.4	2025-07-16	To be published
	8Z9O (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.4	2025-07-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JCP.zip

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