Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.41 1.6775404
2G.S2.03 7.56254119
3G.S3.03 6.13408
4G.S3.04 8.6854117
5G.S3.06 8.286254117
6G.s3h2.03 6.22875419
7G.H2.01 5.1925419
8G.H2.06 6.999519
9G.H2.07 5.736519
10G.H2.10 4.21125418
11G.s4h3.02 4.7454209
12G.H3.09 5.503336199
13G.H3.13 8.9455196
14G.H3.17 9.03375415
15G.S5.04 5.6475409
16G.S5.05 4.54917609
17G.s5hg.01 4.27754209
18G.HG.01 5.02375466
19G.HG.03 4.034206
20G.hgh4.13 3.685404
21G.hgh4.20 3.12625403
22G.hgh4.21 4.82404
23G.H4.03 3.035404
24G.H4.10 9.3995217
25G.H4.12 5.577564
26G.H4.15 6.45875408
27G.h4s6.20 5.2565134
28G.S6.02 8.28754138
29G.S6.05 7.5525465
30G.s6h5.01 4.983754189
31G.H5.08 4.7145128
32G.H5.16 5.766254226
33G.H5.17 10.41634135
34g.l1x4 5.89438
35g.h2x11 10.74146
36g.ctx3 7.66409
37g.ctx6 4.51406
38g.ctx14 5.23875409
39g.ctx16 4.815688
401x60 5.26125406
412x42 5.455408
422x46 5.37254159
432x50 7.2135159
44E1x50 7.7975627
45E1x52 5.335425
463x28 5.426525
473x34 4.468754245
483x50 8.39875409
493x51 8.35625408
50I2x50 4.554228
51I2x51 6.55625406
524x50 4.185409
534x57 3.57754247
544x58 4.7255244
55E2.Y174 6.27405
56E2.Y185 6.00375401
575x39 7.66406
585x47 8.892528
595x48 4.24125425
605x50 4.94875408
615x58 4.424509
625x62 2.73406
635x72 5.236254136
646x37 3.77625408
656x48 6.86667628
666x49 3.15875406
676x51 7.23417626
686x52 7.86333627
697x37 2.64875405
707x39 6.58525
717x42 6.805626
727x45 5.6975409
737x49 5.963754159
747x53 4.068509
757x55 2.77875407
768x50 5.215836239
778x54 3.7054237
78Lig 7.383081320
79b.1x13 2.409507
80b.lh12x2 4.52125408
81b.lhb1x6 3.095403
82b.b1x6 7.035409
83b.l1x3 8.112579
84b.l1x6 10.18519
85b.b2x1 9.067518
86b.b2x5 6.562507
87b.b3x3 4.3508
88b.l3x1 10.64419
89b.l3x2 5.7575179
90b.b4x6 7.91643779
91b.b4x7 7.973754108
92b.l4x2 8.78625484
93b.b5x3 6.8175479
94b.b5x7 6.07625407
95b.l5x1 3.7265288
96b.l5x5 8.606509
97b.b6x1 4.51125419
98b.b6x5 4.60875406
99b.l6x5 7.556254164
100b.b7x1 5.701254164
101b.b8x3 3.51406
102b.b8x4 4.9755286
103b.l9x3 8.51375419
104b.l9x6 5.26063818
105b.b10x5 3.31667609
106b.b11x4 5.03519
107b.l11x2 8.5419
108b.b12x5 3.61506
109b.b12x6 7.826518
110b.b13x7 6.572557
111b.l13x3 7.833559
112b.l13x6 5.151519
113b.b15x2 4.9436
114b.l15x1 4.837517
115b.b16x4 10.105456
116b.b16x6 7.0625658
117b.l17x3 8.02839
118b.b18x3 5.2775438
119b.b18x5 3.735535
120b.l18x1 6.732147146
121b.b19x2 5.65583636
122b.b19x4 5.9925438
123b.l19x1 5.46125419
124b.l19x2 8.365539
125b.b20x2 6.546536
126b.b20x4 11.626538
127b.b20x6 6.1975636
128b.b21x1 8.152537
129b.b21x7 4.20667605
130b.b23x6 7.315697
131b.l23x1 7.505416
132b.b24x4 9.075496
133b.b24x6 5.8775498
134b.b25x3 6.55375495
135b.l25x3 7.823549
136b.l25x6 13.509518
137b.l27x1 11.6625619
138b.l27x2 8.5975449
139b.b28x4 6.255446
140b.b28x6 6.41649
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x2 b.l3x2 18.9816.915NoYes089
2G.hns1.01 b.l3x2 24.09274.6NoYes1749
3G.S1.03 G.hns1.01 32.10979.775NoNo094
4G.S1.03 b.l5x5 24.09344NoYes099
5b.b2x3 b.b2x5 13.49934.07NoYes067
6b.b26x2 b.b2x3 13.78324.86NoNo076
7b.b26x1 b.b26x2 13.92893.44NoNo097
8b.b26x1 b.l27x1 14.07944.94NoYes099
9b.b2x1 b.l27x1 39.942610.61YesYes189
10b.b2x1 b.b6x1 58.48197.185YesYes189
11b.b6x1 b.l9x6 81.07134.19YesYes198
12G.H2.07 b.l9x6 99.17814.34YesYes198
13G.H2.04 G.H2.07 99.79655NoYes099
14G.H2.04 G.H3.08 99.84366.68NoNo098
15G.H3.08 G.S4.04 1005.48NoNo089
16G.H3.09 G.S4.04 66.54955.895YesNo099
17G.H3.09 G.H4.15 33.72978.04YesYes098
18G.H4.15 G.S5.04 65.73598.525YesYes089
19G.S5.04 G.S6.03 90.6343.285YesNo095
20G.H4.12 G.S6.03 90.26346.485YesNo645
21G.H4.12 G.H4.13 90.09144.165YesNo043
22G.H4.13 I3.R239 87.852511.315NoNo034
23I3.F240 I3.R239 87.67623.205NoNo044
24G.h4s6.03 I3.F240 87.50563.245NoNo044
255x76 G.h4s6.03 87.32913.53NoNo034
265x76 G.h4s6.20 86.97564.49NoYes034
27G.H5.17 G.h4s6.20 74.66677.2YesYes1354
285x68 G.H5.17 76.08189.93NoYes075
295x68 G.H5.16 75.3359.6NoYes076
30G.S4.04 G.S4.06 33.50541.965NoNo097
31G.H4.15 G.S4.06 33.45071.965YesNo087
32G.H3.09 G.S6.01 32.85624.19YesNo095
33G.S5.04 G.S6.01 32.98863.17YesNo095
34G.h2s4.01 b.l5x5 10.51512.03NoYes099
35G.S6.02 G.h4s6.20 10.31343.475YesYes1384
36G.H5.10 G.S6.02 11.014710.345NoYes078
37b.b14x1 b.l9x6 17.27013.59NoYes088
38G.H2.06 b.b14x1 17.101111.52YesNo098
39G.H2.06 b.l19x1 17.28934.84YesYes199
40b.l25x6 b.l27x1 27.60223.49YesYes189
41G.H2.10 G.h2s4.01 11.55734.19YesNo089
42G.H2.10 b.l3x1 10.5854.575YesYes189
43b.l3x1 b.l5x5 21.57338.76YesYes099
44b.l23x1 b.l25x6 10.99513.7YesYes168
45G.H5.16 I2x50 71.09853.16YesYes2268
46G.H5.15 I2x50 70.80646.775NoYes088
47G.H5.15 G.H5.19 70.61553.975NoNo088
483x53 G.H5.19 70.23325.125NoNo088
493x46 3x50 19.94653.76NoYes099
502x42 3x46 20.14583.765YesNo089
512x42 3x49 68.11948.36YesNo088
523x49 I2x53 68.50528.05NoNo087
533x53 I2x53 70.04186.675NoNo087
54b.l17x5 b.l19x1 16.94272.205NoYes069
55b.l17x5 b.l19x2 16.76542.21NoYes069
56b.l17x3 b.l19x2 15.11718.195YesYes399
57b.b20x6 b.l17x3 11.45463.39YesYes369
58b.b10x1 b.l9x6 10.28054.45NoYes098
59b.b10x1 b.b11x5 10.10443.26NoNo096
60b.l21x7 b.l23x1 11.30455.445NoYes056
61b.l21x7 b.l23x2 11.14754.67NoNo058
62b.b22x1 b.l25x6 15.30194.525NoYes188
63b.b22x1 b.b22x2 15.63033.2NoNo088
64b.b22x2 b.b26x3 15.48066.01NoNo086
65b.b24x3 b.b26x3 12.41453.17NoNo056
66b.b24x3 b.b25x7 12.09465.555NoNo057
673x33 Lig 22.59438.485NoYes050
683x33 4x57 22.78723.23NoYes057
693x34 4x57 23.16115.255YesYes2457
703x34 4x50 30.86543.99YesYes059
712x45 4x50 32.61044.325NoYes099
722x45 4x46 47.38396.965NoNo098
732x42 4x46 47.58783.14YesNo088
742x46 3x42 14.27513.685YesNo098
752x45 3x42 14.66136.395NoNo098
76b.b25x7 b.b28x6 11.602511.39NoYes479
773x43 7x53 13.13255.86NoYes089
783x50 7x53 14.1863.6YesYes099
792x46 7x49 11.20117.555YesYes1599
803x43 7x49 12.85214.12NoYes1589
816x48 7x45 21.94847.345YesYes089
827x45 7x49 23.59815.45YesYes099
836x48 6x52 13.82384.51YesYes287
845x47 6x52 14.116319.825YesYes287
855x47 6x49 12.76374.265YesYes086
866x49 6x50 10.08133.28YesNo069
87b.b4x2 b.b5x8 17.23925.015NoNo085
88b.b5x7 b.b5x8 16.66583.39YesNo075
89b.l11x1 b.l9x6 15.09224.35NoYes198
90b.b11x6 b.l11x1 15.61763.71NoNo199
91b.b11x6 b.l9x3 14.508214.645NoYes199
92b.b8x3 b.b9x4 11.77123.565YesNo069
93b.b2x1 b.l3x1 10.936916.345YesYes189
94G.H2.10 b.b6x1 22.12314.05YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x533x363.80NoNo7621
2x563x328.032NoNo7721
2x567x424.422NoYes7621
2x577x394.292NoYes7522
2x577x425.682NoYes7621
2x593x286.0152NoYes5521
3x28E1x5011.7152YesYes5712
3x28Lig4.2552YesYes5010
3x327x429.772NoYes7611
3x32Lig17.152NoYes7010
3x334x573.230NoYes5712
3x33Lig8.4850NoYes5010
3x366x488.5850NoYes6812
3x36Lig6.9250NoYes6010
3x375x4619.590NoNo6521
E2.T195E2x525.1850NoNo0421
E2x52Lig10.8450NoYes4010
5x39E2.T1954.9950YesNo6022
5x395x4314.6250YesNo6521
5x43Lig4.9150NoYes5010
5x446x526.6050NoYes5721
5x461Lig4.520NoYes5010
5x475x486.7052YesYes8522
5x476x5219.8252YesYes8721
5x486x523.612YesYes5721
6x486x513.512YesYes8621
6x486x524.512YesYes8721
6x516x526.972YesYes6711
6x516x556.042YesNo6511
6x517x344.1252YesNo6512
6x517x3815.1052YesNo6511
6x51Lig7.6552YesYes6010
6x52Lig5.662YesYes7010
6x557x346.9752NoNo5512
6x55Lig5.9452NoYes5010
7x387x429.3052NoYes5611
7x38Lig13.222NoYes5010
7x397x428.22YesYes5621
7x42Lig3.4552YesYes6010
2x59E1x503.512NoYes5722
3x283x293.0352YesNo5412
2x63Lig2.950NoYes4010
2x603x282.110NoYes7521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
92.31Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
92.31Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
92.31Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
92.31Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
92.31Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
92.31Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
92.31Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
92.31Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
92.31Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
86.67Single6H7LDobutamine6H7L-β1-Dobutamine
86.67Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
86.67Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
85.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
85.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
85.71Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
84.62Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
84.62Single4QKX35V4QKX-β2-35V
84.62Single6H7MSalbutamol6H7M-β1-Salbutamol
84.62Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
84.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
84.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
84.62Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
84.62Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
84.62Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
84.62Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
84.62Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
84.62Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
84.62Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
84.62Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
84.62Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
84.62Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
84.62Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
80.00Single4AMIBucindolol4AMI-β1-Bucindolol
80.00Single4LDEBI1671074LDE-β2-BI167107
80.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
80.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
80.00Single8JJ8Formoterol8JJ8-β2-Formoterol
80.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
80.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
80.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
80.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
78.57Single2RH1S-Carazolol2RH1-β2-S-Carazolol
78.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
78.57Single5JQHS-Carazolol5JQH-β2-S-Carazolol
78.57Single5WIUNemonapride5WIU-D4-Nemonapride
78.57Single5WIVNemonapride5WIV-D4-Nemonapride-Na
78.57Single6E67BI1671076E67-β2-BI167107-Gs (fused)
78.57Single7WC6LSD7WC6-5-HT2A-LSD
78.57Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
78.57Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
78.57Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
78.57Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
78.57Consensusamine_offonOrthosteric Ligandamine_off amine_on
78.57Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
78.57Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
78.57Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
78.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
78.57Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
76.92Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
76.92Single6PS0S-Carazolol6PS0-β2-S-Carazolol
76.92Single6PS4ICI118-5516PS4-β2-ICI118-551
76.92Single6PS5S-Propranolol6PS5-β2-S-Propranolol
76.92Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
76.92Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
76.92Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
76.92Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
76.92Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
76.92Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
76.92Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
76.92Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
76.92Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
76.92Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
76.47Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
76.47Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
75.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
75.00Single6IBLArformoterol6IBL-β1-Arformoterol
75.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
73.33Single3P0GBI1671073P0G-β2-BI167107
73.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
73.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
73.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
73.33Single5D5AS-Carazolol5D5A-β2-S-Carazolol
73.33Single5D5BS-Carazolol5D5B-β2-S-Carazolol
73.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
73.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
73.33Single6WGTLSD6WGT-5-HT2A-LSD
73.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
73.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
73.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
73.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
73.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
73.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
73.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
73.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
73.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
73.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
73.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
73.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
73.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
73.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
71.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
71.43Single2Y02Carmoterol2Y02-β1-Carmoterol
71.43Single2Y04Salbutamol2Y04-β1-Salbutamol
71.43Single3NY8ICI118-5513NY8-β2-ICI118-551
71.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
71.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
71.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
71.43Single6PS1Timolol6PS1-β2-Timolol
71.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
71.43Single7BU7BI1671077BU7-β1-BI167107
71.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
71.43Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
71.43Single7WC7Lisuride7WC7-5-HT2A-Lisuride
71.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
71.43Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8JJOAlprenolol8JJO-β2-Alprenolol
71.43Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
71.43Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
71.43Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
71.43Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Consensus5ht5_onOrthosteric Ligand5ht5a_on
71.43Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
71.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
71.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
71.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
70.59Single8X5YAstemizole8X5Y-H1-Astemizole
69.23Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
69.23Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
69.23Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
69.23Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
69.23Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
69.23Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
69.23Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
69.23Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
69.23Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
69.23Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
69.23Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
69.23Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
69.23Consensusalpha2_offOrthosteric Ligandalpha2c_off
69.23Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
68.75Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
68.75Single3D4STimolol3D4S-β2-Timolol
68.75Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
68.75Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
68.75Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
68.75Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
68.75Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
68.75Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
68.75Single8JJLOlodaterol8JJL-β2-Olodaterol
68.75Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
68.75Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
68.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
66.67Single2Y00Dobutamine2Y00-β1-Dobutamine
66.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
66.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
66.67Single5TVNLSD5TVN-5-HT2B-LSD
66.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
66.67Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
66.67Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
66.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
66.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
66.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
66.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
66.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
66.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
66.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
66.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Consensustrace-amine_onOrthosteric Ligandta1_on
64.71Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
64.71Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
64.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
64.29Single6KUXRS-799486KUX-α2a-RS-79948
64.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
64.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
64.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
64.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
64.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
64.29Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
64.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
64.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
64.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
64.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
64.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
64.29Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
64.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
64.29Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
64.29Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
64.29Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
62.50Single2YDVNECA2YDV-A2A-NECA
62.50Single4UHRCGS216804UHR-A2A-CGS21680
62.50Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
62.50Single5G53NECA5G53-A2A-NECA-Gs
62.50Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
62.50Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
62.50Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
62.50Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
62.50Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
62.50Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
62.50Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
62.50Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
61.54Single3PBLEticlopride3PBL-D3-Eticlopride
61.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
61.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
61.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
61.54Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
61.54Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
61.54Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
61.54Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
61.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
61.11Single3NY9ICI118-5513NY9-β2-ICI118-551
61.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
60.00Single2Y01Dobutamine2Y01-β1-Dobutamine
60.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
60.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
60.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
60.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
60.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
60.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
60.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
60.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
60.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
60.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
60.00Single8JXRLSD8JXR-D1-LSD
60.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
60.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
60.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
60.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
60.00Single8X64Desloratadine8X64-H1-Desloratadine
60.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
60.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
60.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
60.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
60.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
60.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
58.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
58.82Single6MXTSalmeterol6MXT-β2-Salmeterol
58.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
58.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
58.82Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
58.82Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
57.89Single4IARErgotamine4IAR-5-HT1B-Ergotamine
57.89Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
57.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
57.14Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
57.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
57.14Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
57.14Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
57.14Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
57.14Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
57.14Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
57.14Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
57.14Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
57.14Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
57.14Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
57.14Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
57.14Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
57.14Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
57.14Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
57.14Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
56.25Single5C1MBU725C1M-μ-BU72
56.25Single6PS6Timolol6PS6-β2-Timolol
56.25Single7C61Ergotamine7C61-5-HT1B-Ergotamine
56.25Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
56.25Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
56.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
56.25Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
56.25Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
56.25Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
55.56Single5X93K-87945X93-ETB-K-8794
55.56Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
55.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
55.56Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
55.56Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
55.56Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
55.56Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
55.56Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
53.85Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
53.85Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
53.33Single6A94Zotepine6A94-5-HT2A-Zotepine
53.33Single6TPGEMPA6TPG-OX2-EMPA
53.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
53.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
53.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
53.33Single7UL3Famotidine7UL3-H2-Famotidine
53.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
53.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
53.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
53.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
53.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
53.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
53.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
53.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
53.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
53.33Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
53.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
53.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
53.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single6J21Aprepitant6J21-NK1-Aprepitant
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single6TQ7SB-3348676TQ7-OX1-SB-334867
52.94Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
52.94Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
52.94Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
52.94Single8E0GBU728E0G-μ-BU72
52.94Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
52.94Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
52.94Single8XVLZibotentan8XVL-ETA-Zibotentan
52.94Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.94Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Consensustachykinin_offOrthosteric Ligandnk1_off
52.63Single4UG2CGS216804UG2-A2A-CGS21680
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
50.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5DHGC-355DHG-NOP-C-35
50.00Single5DHHSB-6121115DHH-NOP-SB-612111
50.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
50.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
50.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
50.00Single7UL4Alvimopan7UL4-μ-Alvimopan
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
50.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
50.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
50.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
50.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
50.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
50.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
50.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
50.00Single8WDTphotoNECA8WDT-A2A-photoNECA
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
50.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
50.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
50.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
50.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
50.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
50.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
50.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
50.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
50.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
50.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
47.83Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
47.62Single6HLOAprepitant6HLO-NK1-Aprepitant
47.62Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
47.37Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.37Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.37Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
47.37Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
47.37Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.37Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
47.37Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
47.37Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
47.06Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
47.06Single5WQCEMPA5WQC-OX2-EMPA
47.06Single6LUQHaloperidol6LUQ-D2-Haloperidol
47.06Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
47.06Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
47.06Single6TP6Filorexant6TP6-OX1-Filorexant
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.06Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
47.06Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8JXSPF-61428JXS-D1-PF-6142
47.06Single8ZMFA1L108ZMF-5-HT2C-A1L10
47.06Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.06Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6TODEMPA6TOD-OX1-EMPA-Na
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
46.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.67Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
46.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
46.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.67Single8IWESpermidine8IWE-TA9-Spermidine
46.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
46.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
46.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
46.15Single9CHUNoradrenaline9CHU-β2-Noradrenaline
46.15Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
46.15Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
45.83Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
45.45Single6PT2KGCHM076PT2-δ-KGCHM07
45.45Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
45.00Single6PT3DPI-2876PT3-δ-DPI-287
45.00Single7XN9L-054,5227XN9-SST2-L-054,522
45.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
44.44Single6J20Aprepitant6J20-NK1-Aprepitant
44.44Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
44.44Single7B6WCyclazosin7B6W-α1b-Cyclazosin
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
44.44Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
44.44Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
44.44Single8EA0Iperoxo8EA0-M3-Iperoxo
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
44.44Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
44.44Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
44.44Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
44.44Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
44.44Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensusa2_onOrthosteric Liganda2b_on
44.44Consensusa2_on_gpOrthosteric Liganda2b_on_gp
44.44Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
44.44Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
44.44Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
44.44Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
43.75Single2YDOAdenosine2YDO-A2A-Adenosine
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
43.75Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single4ZJCSB-6740424ZJC-OX1-SB-674042
43.75Single6IQLL7458706IQL-D4-L745870
43.75Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
43.75Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
43.75Single6TPNHTL66416TPN-OX2-HTL6641
43.75Single6VI4JDTic6VI4-κ-JDTic
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
43.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
43.75Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
43.75Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
43.75Single9BJKNaloxone9BJK-μ-Naloxone-NAM
43.75Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
43.75Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
43.75Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
43.48Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
43.48Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single3UZAGTPL92363UZA-A2A-GTPL9236
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
42.86Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
42.86Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
42.86Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensus5ht2_onOrthosteric Ligand5ht2b_on
42.86Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
42.86Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.11Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.11Single6CM4Risperidone6CM4-D2-Risperidone
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
42.11Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
42.11Single8JWY2-1188JWY-A2A-2-118
42.11Single8JWZAB9288JWZ-A2A-AB928-Na
42.11Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
42.11Consensusorexin_onOrthosteric Ligandox2_on
41.67Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
41.18Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
41.18Single4DAJTiotropium4DAJ-M3-Tiotropium
41.18Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
41.18Single5DSGTiotropium5DSG-M4-Tiotropium
41.18Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
41.18Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
41.18Single5UIGCmpd-15UIG-A2A-Cmpd-1
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
41.18Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8CU6LJ-45178CU6-A2A-LJ-4517
41.18Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
41.18Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
41.18Single8T1WCVN4248T1W-GPR6-CVN424
41.18Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
41.18Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
41.18Consensusa3_onOrthosteric Liganda3a_on
41.18Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
41.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
41.18Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
40.91Single3QAKUK-4320973QAK-A2A-UK-432097
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
40.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
40.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
40.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
40.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
40.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
40.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
40.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
39.13Single5WF5UK-4320975WF5-A2A-UK-432097
39.13Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
39.13Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
39.13Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.13Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
39.13Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
39.13Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
39.13Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
38.89Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
38.89Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
38.89Single5XPRBosentan5XPR-ETB-Bosentan
38.89Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
38.89Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
38.89Single6HLPNetupitant6HLP-NK1-Netupitant
38.89Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
38.89Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
38.89Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
38.89Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
38.89Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
38.89Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
38.89Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
38.89Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
38.89Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
38.89Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
38.89Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
38.89Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
38.89Consensusa3_on_gpOrthosteric Liganda3a_on_gp
38.89Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.89Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.46Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
38.46Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
38.10Single5WF6UK-4320975WF6-A2A-UK-432097
38.10Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
38.10Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
38.10Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
38.10Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.10Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.10Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
37.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
37.50Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
37.50Single5WS3EMPA5WS3-OX2-EMPA
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6B73MP11046B73-κ-MP1104
37.50Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
37.50Single6DS0Ly2660976DS0-5-HT2B-Ly266097
37.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
37.50Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
37.50Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
37.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
37.50Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.50Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
37.50Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
37.50Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
37.50Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
37.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
37.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
36.84Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.84Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
36.84Single6E59L-7607356E59-NK1-L-760735
36.84Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
36.84Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
36.84Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
36.84Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
36.84Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
36.84Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
36.36Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.36Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
36.36Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
35.71Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusbombesin_onOrthosteric Ligandbb2_on
35.71Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
35.71Consensussensory_onOrthosteric Ligandopsins_on
35.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
35.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6V9SGTPL114036V9S-OX1-GTPL11403
35.29Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.29Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
35.29Single8IHKAcifran8IHK-HCA3-Acifran
35.29Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
35.29Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
35.29Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
35.29Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
35.29Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
35.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
35.29Consensussensory_offOrthosteric Ligandopsins_off
35.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.00Single6A93Risperidone6A93-5-HT2A-Risperidone
35.00Single7DFPSpiperone7DFP-D2-Spiperone
35.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
35.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
35.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
35.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8XYIVUF106618XYI-CXCR3-VUF10661
35.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
34.78Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.78Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
34.78Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single6K1QIRL25006K1Q-ETB-IRL2500
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
33.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
33.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
33.33Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8RLNLUF58348RLN-A2A-LUF5834
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
33.33Single8XVJMacitentan8XVJ-ETA-Macitentan
33.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
33.33Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
33.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
33.33Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
33.33Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
33.33Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
33.33Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
33.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
32.14Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
32.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
32.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
32.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
32.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
31.82Single5ZTYAM102575ZTY-CB2-AM10257
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
31.82Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.82Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
31.82Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.82Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
31.58Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
31.58Single5N2SPSB365N2S-A1-PSB36
31.58Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.58Single7W41PD1762527W41-BB2-PD176252
31.58Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
31.58Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
31.58Single8S4DCMF-0198S4D-Apelin-CMF-019
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
31.58Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.58Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
31.58Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
31.58Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.58Consensusbombesin_offOrthosteric Ligandbb2_off
31.58Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
31.58Consensusdp_offOrthosteric Liganddp2_off
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
31.25Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
31.25Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
31.25Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
31.25Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
31.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
31.25Single8K5BNiacin8K5B-HCA2-Niacin
31.25Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
31.25Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.25Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
31.25Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
31.25Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
31.03Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
30.77Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.77Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
30.43Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
30.43Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
30.43Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
30.43Consensuslpl_onOrthosteric Ligands1p_on lpa_on
30.43Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
30.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
30.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
30.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
30.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
30.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
30.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
30.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.63Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.41Single4S0VSuvorexant4S0V-OX2-Suvorexant
29.41Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
29.41Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
29.41Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
29.41Single6TPJSuvorexant6TPJ-OX2-Suvorexant
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
29.41Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
29.41Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
29.41Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.41Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
29.41Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
29.41Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
29.41Single8Y0HVUF114188Y0H-CXCR3-VUF11418
29.41Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.41Consensusangiotensin_offOrthosteric Ligandat1_off
29.41Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.41Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
29.41Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.41Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
29.17Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
29.17Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
29.17Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
28.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
28.57Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
28.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
28.57Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
28.57Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
28.57Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7WC4Serotonin7WC4-5-HT2A-Serotonin
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.57Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.57Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
28.57Single8PWNTheophylline8PWN-A2A-Theophylline
28.57Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
28.57Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
28.57Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
28.57Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
28.57Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
28.57Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
28.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.57Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.57Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.57Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
28.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
28.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
28.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
27.78Single3REYXAC3REY-A2A-XAC
27.78Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5IUBQ274563445IUB-A2A-Q27456344-Na
27.78Single5JTBZM-2413855JTB-A2A-ZM-241385
27.78Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
27.78Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
27.78Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
27.78Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
27.78Single6AQFZM-2413856AQF-A2A-ZM-241385
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7AROLUF58337ARO-A2A-LUF5833-Na
27.78Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
27.78Single7T32ZM-2413857T32-A2A-ZM-241385
27.78Single7VODCariprazine7VOD-5-HT2A-Cariprazine
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.78Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
27.78Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
27.78Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
27.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
27.78Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
27.78Single8K5CAcipimox8K5C-HCA2-Acipimox
27.78Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
27.78Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
27.78Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
27.78Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
27.78Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensusa2_offOrthosteric Liganda2a_off
27.78Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
27.78Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensushca_onOrthosteric Ligandhca2_on
27.59Single6IGLIRL16206IGL-ETB-IRL1620
27.59Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
27.59Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
27.59Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
27.59Consensusbradykinin_onOrthosteric Ligandbk2_on
27.59Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
27.59Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
27.27Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
27.27Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
27.27Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
27.27Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
27.27Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
27.27Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensuschemerin_onOrthosteric Ligandcml1_on
27.27Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.92Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
26.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
26.32Single3EMLZM-2413853EML-A2A-ZM-241385
26.32Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
26.32Single4YAYZD-71554YAY-AT1-ZD-7155
26.32Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.32Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
26.32Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
26.32Single5UENDU1725UEN-A1-DU172
26.32Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
26.32Single6D27CAY104716D27-DP2-CAY10471
26.32Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
26.32Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
26.32Single6S0LZM-2413856S0L-A2A-ZM-241385
26.32Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7PYRPSB-21157PYR-A2A-PSB-2115
26.32Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
26.32Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
26.32Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
26.32Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
26.32Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
26.32Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusblt_onOrthosteric Ligandblt1_on
26.32Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
26.32Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
26.32Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
26.32Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
26.32Consensushca_on_gpOrthosteric Ligandhca2_on_gp
26.32Consensusleukotriene_onOrthosteric Ligandblt_on
26.32Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
26.32Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
26.32Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
26.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
26.09Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.09Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
26.09Single8QJ2pN1628QJ2-MC4-pN162-Gs
26.09Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
26.09Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.93Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
25.93Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.93Single8ZRTET-18ZRT-ETB-ET-1
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.93Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
25.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
25.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
25.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
25.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
25.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
25.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
25.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
24.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
24.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
24.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
24.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
24.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
24.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
24.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.81Single5XR8AM8415XR8-CB1-AM841
23.81Single5XRAAM115425XRA-CB1-AM11542
23.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.81Single7PX4PSB-21137PX4-A2A-PSB-2113
23.81Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
23.81Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
23.81Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
23.81Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
23.81Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.81Single9BJKNAM9BJK-μ-Naloxone-NAM
23.81Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
23.81Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Consensuslpa_onOrthosteric Ligandlpa1_on
23.81Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
23.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.81Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
23.53Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
23.53Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
23.53Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
23.53Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
23.53Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
23.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
23.53Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
23.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
23.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.08Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
23.08Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.73Single4N4WSANT-14N4W-SMO-SANT-1
22.73Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single7K15MKD0467K15-BLT1-MKD046-Na
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
22.73Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
22.73Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
22.73Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.73Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
22.73Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
22.73Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.73Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
22.73Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
22.73Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
22.73Consensuslpl_offOrthosteric Ligands1p_off lpa_off
22.58Single5GLHEndothelin-15GLH-ETB-Endothelin-1
22.58Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
22.58Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single3PWHZM-2413853PWH-A2A-ZM-241385
22.22Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
22.22Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
22.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
22.22Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.22Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
22.22Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
22.22Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
22.22Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
22.22Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
22.22Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
22.22Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
22.22Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
22.22Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.22Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
22.22Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
22.22Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
22.22Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
21.88Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.88Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
21.88Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.74Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
21.74Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.74Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
21.74Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.74Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
21.74Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.43Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.43Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
21.43Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.43Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.05Single5UVIZM-2413855UVI-A2A-ZM-241385
21.05Single6MH8ZM-2413856MH8-A2A-ZM-241385
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
21.05Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
21.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
21.05Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensusvasop-oxy_offOrthosteric Ligandot_off
20.83Single5EE7MK08935EE7-Glucagon-MK0893
20.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.83Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.83Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.83Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.69Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single4XT1Fractalkine4XT1-US28-Fractalkine
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Single8WKYPG-9348WKY-MC4-PG-934
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.44Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.35Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
19.35Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.35Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.35Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
19.23Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
19.23Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
19.23Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
19.23Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single6GPXMK08126GPX-CCR2-MK0812
19.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
19.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.05Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
19.05Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
19.05Consensusblt_offOrthosteric Ligandblt1_off
19.05Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
19.05Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
19.05Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.75Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.75Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.75Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.52Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
18.52Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.52Single6W25SHU91196W25-MC4-SHU9119-Ca
18.52Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
18.52Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
18.52Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.52Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.52Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.52Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.18Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.18Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.18Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
18.18Single7FEECP559407FEE-CB1-CP55940-ZCZ011
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7R0CAVP7R0C-V2-AVP-Arrestin2
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.18Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
18.18Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
18.18Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
18.18Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
18.18Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.18Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.18Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.86Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.86Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
17.86Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.86Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.86Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
17.86Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.86Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
17.65Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.39Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.39Single6KQICP559406KQI-CB1-CP55940-Org27569
17.39Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.39Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
17.39Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.39Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
17.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
17.24Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
17.24Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
17.24Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.24Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
17.24Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
16.67Single4XT3Fractalkine4XT3-US28-Fractalkine
16.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
16.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
16.67Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.67Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.67Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.13Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.13Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
16.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
15.79Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.79Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.62Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
15.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
15.62Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.38Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
15.38Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
15.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
15.38Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
15.38Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
15.38Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.38Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
15.15Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
15.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.81Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.81Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
14.81Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.81Single8IEBA1LYA8IEB-GPR156-A1LYA
14.81Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.81Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
14.81Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.81Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
14.71Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
14.71Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
14.29Single3OE0CVX153OE0-CXCR4-CVX15
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6IIVDaltroban6IIV-TP-Daltroban
14.29Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.29Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.29Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
14.29Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
13.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
13.79Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
13.79Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.79Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
13.79Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
13.79Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
13.64Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.64Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.51Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
13.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.33Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
13.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.04Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
13.04Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.04Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
13.04Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.90Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
12.90Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.90Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.90Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
12.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.90Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
12.50Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
12.50Single5X33BIIL2605X33-BLT1-BIIL260
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
12.50Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.50Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
12.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.50Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.50Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.50Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.50Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
12.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.20Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.12Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.12Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.12Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.12Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.12Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
11.76Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.54Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.54Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.54Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.54Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.43Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.43Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.11Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.11Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.11Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.11Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
11.11Consensussomatostatin_offOrthosteric Ligandsst2_off
10.81Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.81Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.81Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.71Single7XNACYN1548067XNA-SST2-CYN154806
10.71Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6LI0C176LI0-GPR52-C17
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.53Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.53Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.53Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.53Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single9BA0A1AKN9BA0-CB1-A1AKN
10.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
9.68Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.68Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.68Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.68Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
9.52Single8K2WAMG4878K2W-CXCR3-AMG487
9.52Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.38Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.38Single7SK3CXCL127SK3-ACKR3-CXCL12
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.09Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
8.82Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
8.70Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
8.70Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.70Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.70Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.70Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.57Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.33Single5TZRMK86665TZR-FFA1-MK8666
8.33Single5V56TC1145V56-SMO-TC114
8.33Single6OS1TRV0266OS1-AT1-TRV026
8.33Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.33Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
8.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.33Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.33Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.00Single4XESNeurotensin4XES-NTS1-Neurotensin
8.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
8.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
8.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
7.69Single4BUONeurotensin4BUO-NTS1-Neurotensin
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
7.69Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
7.69Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.41Single8XQJJN2418XQJ-Apelin-JN241
7.41Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.41Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.14Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
6.90Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.67Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.67Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.25Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.88Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
5.88Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.56Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.56Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.26Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.26Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.13Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
4.76Single4XNVBPTU4XNV-P2Y1-BPTU
4.76Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.76Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.76Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
4.76Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55Single6ZINSR486926ZIN-NTS1-SR48692
4.55Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.55Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.35Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.35Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.35Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.35Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.35Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.35Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.35Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.35Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.35Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.35Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.17Single4JKVTaladegib4JKV-SMO-Taladegib
4.17Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.17Single6Z4SSR486926Z4S-NTS1-SR48692
4.17Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.17Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.00Single5V57TC1145V57-SMO-TC114
4.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusneurotensin_onOrthosteric Ligandnts1_on
4.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.85Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.85Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.85Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
3.85Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
3.85Single8XQJJN2418XQJ-Apelin-JN241
3.85Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.85Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.85Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.70Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.70Single8XVUCXCL28XVU-CXCR2-CXCL2
3.70Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.57Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.57Single6KNMJN241-96KNM-Apelin-JN241-9
3.57Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.57Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.45Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single8XWNCXCL88XWN-CXCR2-CXCL8
3.45Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7DHI 7DHI-β2-Salbutamol-Gs/β1/γ2
6NI3 6NI3-β2-BI167107-Gs/β1/γ2
Net Summary
Imin 3.08
Number of Linked Nodes 889
Number of Links 1020
Number of Hubs 140
Number of Links mediated by Hubs 535
Number of Communities 29
Number of Nodes involved in Communities 177
Number of Links involved in Communities 239
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 1670576
Length Of Smallest Path 3
Average Path Length 34.678
Length of Longest Path 66
Minimum Path Strength 0.77
Average Path Strength 5.90764
Maximum Path Strength 21.74
Minimum Path Correlation 0.7
Average Path Correlation 0.978584
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 36.4356
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.6465
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
beta2_off_on_gpbeta2_on_gpbeta2_off
This network is also present in following consensuses:
IdComponents
beta_on_gpbeta1_on_gp
beta2_on_gp
beta3_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta2_on_gp.zip



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