Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 2.0116503
2G.HN.43 3.25317408
3G.HN.45 2.13142404
4G.S1.02 5.10227544
5G.S1.04 3.37208447
6G.S1.06 4.52742448
7G.S1.07 4.39058419
8G.S2.01 3.90892419
9G.S2.03 5.134418
10G.S2.08 6.2856545
11G.S3.03 6.59339647
12G.S3.04 6.767416
13G.S3.06 7.06911616
14G.S3.07 4.60642449
15G.s3h2.03 4.2432519
16G.H2.03 4.15775419
17G.H2.04 4.00175419
18G.H2.06 4.96362719
19G.H2.07 4.64338719
20G.H2.09 6.64458418
21G.h2s4.01 5.68839619
22G.S4.02 4.56433417
23G.S4.03 3.46058447
24G.S4.04 4.97433619
25G.s4h3.02 3.8945459
26G.s4h3.04 4.47014758
27G.H3.01 4.40092409
28G.H3.09 5.26443719
29G.H3.13 4.02725415
30G.H3.17 6.08083614
31G.H3.18 5.89325419
32G.S5.03 3.04858448
33G.S5.04 3.8812519
34G.S5.05 3.818649
35G.S5.07 4.11092449
36G.HG.04 5.4406558
37G.HG.13 3.03033456
38G.HG.15 3.30817407
39G.hgh4.01 4.00933454
40G.hgh4.02 5.87911658
41G.H4.03 7.22908403
42G.H4.10 9.39533456
43G.H4.15 4.60813518
44G.h4s6.02 4.92942417
45G.h4s6.12 5.783254114
46G.S6.02 5.464226118
47G.S6.05 4.11542405
48G.s6h5.05 1.7466509
49G.H5.03 4.92567448
50G.H5.08 4.80106648
51G.H5.20 3.9084508
52G.H5.26 7.11442405
53b.1x4 1.728608
54b.h2x1 2.56913505
55b.lhb1x3 2.439502
56b.lhb1x6 4.150584153
57b.l1x3 7.09428789
58b.b2x1 8.17847518
59b.b2x5 7.6296507
60b.b3x3 3.42975408
61b.l3x2 4.81093589
62b.b4x2 4.3685408
63b.b4x3 4.234834177
64b.b4x5 4.182174107
65b.b4x6 8.41052789
66b.l4x2 10.552474
67b.b5x2 5.28342407
68b.b5x3 6.11389689
69b.b5x5 5.174105
70b.b5x7 5.15342407
71b.l5x1 3.60465178
72b.l5x5 7.292719
73b.b6x5 3.5447106
74b.l6x5 5.231674134
75b.b7x1 5.555475134
76b.l7x2 3.60422619
77b.l7x4 3.08587509
78b.b8x3 3.37254136
79b.b8x4 5.13085176
80b.l8x1 3.753754105
81b.l9x3 7.18267519
82b.l9x6 4.371231018
83b.b10x5 4.346609
84b.l10x1 4.05403
85b.b11x4 4.8215419
86b.b11x5 4.60392406
87b.l11x2 8.22233419
88b.b12x3 2.99733468
89b.b12x5 3.23842466
90b.b12x6 7.11371718
91b.b13x7 7.969567
92b.l13x3 7.05706669
93b.l13x6 5.3562519
94b.b15x1 6.41567669
95b.b15x2 7.09683416
96b.b15x3 4.57133469
97b.l15x1 5.067517
98b.l15x2 5.15987569
99b.b16x4 10.159466
100b.b16x5 4.0746505
101b.b16x6 8.2675668
102b.b17x5 6.81617417
103b.b17x7 8.60375418
104b.l17x3 6.90586719
105b.l17x6 5.921519
106b.b18x3 5.13025418
107b.l18x1 5.278298146
108b.l18x2 5.780584147
109b.l18x3 6.928334145
110b.b19x2 6.93344616
111b.b19x4 5.01527518
112b.l19x2 5.79907519
113b.b20x4 10.2067518
114b.b20x6 6.79756616
115b.b20x7 4.16375409
116b.l20x2 5.02047509
117b.b21x1 5.89733517
118b.b21x2 2.30833406
119b.b21x4 4.24267405
120b.b21x5 4.88317404
121b.b21x7 5.2785605
122b.l21x5 4.07317494
123b.b22x5 5.919334147
124b.l22x5 4.784057159
125b.b23x6 6.50333797
126b.l23x1 7.32592406
127b.b24x4 7.02517496
128b.b24x6 6.82008498
129b.l24x2 4.010334156
130b.b25x3 6.30093595
131b.l25x3 9.128275129
132b.b26x3 3.82175406
133b.b27x1 2.54975406
134b.l27x1 10.473719
135b.l27x2 8.097834129
136b.b28x3 4.21542487
137b.b28x4 7.655424126
138b.b28x6 9.769584129
139b.b28x7 6.26558479
140g.h1x1 1.08017402
141g.l1x4 2.78387508
142g.h2x11 8.4444146
143g.ctx3 5.35617609
144g.ctx6 3.90883406
145g.ctx14 3.70106679
146g.ctx15 5.41783479
147g.ctx16 4.21054878
148Lig 33.27382320
149NT 15.5923523
1501x39 5.1486528
1511x57 2.95517407
1521x59 3.03125404
1532x37 2.98908408
1542x38 4.65265166
1552x42 5.843836167
1562x46 3.00483439
1572x50 5.92142439
1582x53 6.55908426
1592x57 3.8298528
1602x60 5.85867426
1612x63 5.03567425
162E1x50 7.34517628
163E1x52 5.196527
1643x32 5.1059727
1653x36 4.70325437
1663x37 3.75156637
1673x38 4.10325437
1683x41 3.01783435
1693x42 6.30578637
1703x49 6.452174168
1713x50 5.67692409
1723x51 6.413834218
1734x50 5.59108439
174E2 15.99311424
175E2x52 3.62017425
1765x35 4.74253522
1775x47 5.25458408
1785x50 3.888409
1795x58 5.34857739
180I3 4.218675114
1816x34 2.4525406
1826x40 2.844437
1836x44 5.32567539
1846x47 3.9368507
1856x48 7.21193539
1866x49 4.0755406
1876x51 6.55775407
1886x60 2.6885405
1896x61 3.0535424
190E3 3.79111624
1917x30 2.37583404
1927x37 4.07308406
1937x38 5.55217426
1947x42 5.66813527
1957x45 7.19593539
1967x49 4.60961639
1977x53 4.86439639
1988x50 5.6066508
1998x53 5.51575405
200I2x57 4.909675160
201g.ntx4 0.633333400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x2 b.b4x6 10.00875.201NoYes059
2b.b2x5 b.b3x2 10.251913.818YesNo075
3b.b2x3 b.b2x5 18.54913.79967NoYes067
4b.b26x2 b.b2x3 18.92145.346NoNo076
5b.b26x1 b.b26x2 19.31723.44NoNo097
6b.b26x1 b.l27x1 19.51995.682NoYes099
7b.b2x1 b.l27x1 12.46827.878YesYes189
8b.b2x1 b.l3x1 12.901614.2007YesNo189
9b.l3x1 b.l5x5 13.31215.40367NoYes199
10G.H3.17 b.l27x1 15.36042.46767YesYes149
11G.H3.15 G.H3.17 58.31214.70267NoYes084
12G.H3.15 G.H3.18 58.45814.06533NoYes089
13G.H3.18 G.S4.02 49.88287.911YesYes197
14G.S1.07 G.S4.02 50.00912.80467YesYes197
15G.S1.07 G.S4.04 54.73512.682YesYes199
16G.S4.04 G.S5.04 96.12033.41YesYes199
17G.S5.04 G.S5.06 95.74383.508YesNo098
18G.S5.06 G.S6.05 91.05677.18633NoYes085
19G.HG.01 G.S6.05 91.42862.72133NoYes055
20G.HG.01 G.s6h5.02 1005.76533NoNo057
21G.s6h5.02 G.s6h5.05 99.96921.76333NoYes079
22G.H1.07 G.s6h5.05 99.85473.003NoYes009
23G.H1.07 G.H5.03 99.83645.852NoYes008
24G.H5.03 G.S5.05 98.69263.94567YesYes489
25G.HG.04 G.s4h3.04 10.21994.849YesYes588
26b.l5x5 b.l7x2 12.37555.014YesYes199
27b.b2x4 b.b6x5 16.8512.616NoYes066
28b.b10x4 b.b2x4 16.962614.5543NoNo066
29b.b10x2 b.b10x4 15.44553.94733NoNo066
30b.b10x2 b.b14x3 15.62726.032NoNo065
31b.b11x5 b.b14x3 17.00246.75667YesNo065
32b.b10x1 b.b11x5 27.53583.586NoYes096
33b.b10x1 b.l9x6 27.75012.542NoYes098
34G.S5.03 G.S5.05 93.24743.39267YesYes489
35G.H5.10 G.S5.03 98.21933.52NoYes078
36G.H5.10 G.S6.02 98.18125.29233NoYes078
37G.S6.02 I3 96.50744.38767YesYes1184
386x29 I3 97.38993.356NoYes054
396x29 G.H5.26 97.30512.5687NoYes055
40G.H5.20 G.H5.26 97.02617.75233YesYes085
41G.H5.20 G.H5.25 84.1293.875YesNo086
423x50 G.H5.25 72.12396.55767YesNo096
433x50 5x58 12.80746.44667YesYes099
446x37 G.H5.25 12.3262.63567NoNo076
455x58 6x37 12.4228.682YesNo097
463x54 G.H5.20 12.3553.52567NoYes088
473x54 5x61 12.19474.97833NoNo088
485x58 5x61 12.15393.388YesNo098
49G.H2.07 b.l9x6 56.69713.826YesYes198
50G.H2.06 b.l9x6 33.05893.223YesYes198
51G.H2.04 G.H3.08 50.61685.353YesNo099
52G.H2.06 b.l17x6 31.42277.88267YesYes199
53G.H4.03 G.HG.01 10.12975.931YesNo035
542x38 2x42 10.47118.16433YesYes1667
552x42 3x46 31.01833.286YesNo079
563x46 7x53 31.19743.82767NoYes099
573x50 7x53 61.07675.38533YesYes099
582x42 3x49 19.07884.90667YesYes1678
592x37 I2x57 17.67552.875YesYes080
60b.h2x1 b.h2x5 14.50722.703YesNo055
61b.b21x4 g.h2x1 13.18852.88067YesNo058
62b.b21x2 g.h2x1 12.86093.44033YesNo068
63b.1x2 b.b21x2 11.89141.285NoYes016
64b.1x2 b.1x3 11.58082.37733NoNo011
65b.1x3 b.1x4 10.93931.28567NoYes018
66b.l17x5 b.l17x6 32.26493.92633NoYes169
67b.l17x5 b.l19x2 32.02034.221NoYes169
68b.l17x3 b.l19x2 29.65714.37YesYes199
69b.b20x6 b.l17x3 14.6722.678YesYes169
70b.b21x5 b.h2x1 12.84185.22867YesYes045
71b.b3x3 b.b6x5 11.13124.41667YesYes086
72b.l11x1 b.l9x6 19.98885.26333NoYes198
73b.b11x6 b.l11x1 21.02312.97NoNo199
74b.b11x6 b.l9x3 19.150915.2047NoYes199
75b.b12x6 b.l9x3 17.33284.62YesYes189
76b.b11x2 b.b12x6 15.21722.817NoYes078
77b.b19x4 b.l17x3 12.9377.52867YesYes189
78b.b15x2 b.b19x2 11.490410.226YesYes166
79b.l25x6 b.l27x1 10.372718.8567NoYes189
80b.l23x1 b.l25x6 52.321618.0643YesNo068
81b.l21x7 b.l23x1 40.28725.02967NoYes056
82b.b23x6 b.l21x7 38.65713.13567YesNo975
83b.b23x6 b.b24x6 35.07887.009YesYes978
84b.b21x7 b.b24x6 35.02888.32767YesYes058
85b.b21x7 b.b23x2 12.12813.79YesNo056
86b.b21x5 b.b21x7 14.37039.42133YesYes045
87b.b22x5 b.b23x2 10.89079.70167YesNo076
88b.b20x5 b.b21x4 11.63023.184NoYes075
89b.b22x1 b.l23x1 12.51823.806NoYes086
90b.b22x1 b.b22x2 12.24342.98667NoNo088
917x49 7x53 37.63036.51133YesYes399
922x50 7x49 27.83573.861YesYes399
932x50 7x46 27.6875.03267YesNo098
942x53 7x46 27.514.70067YesNo068
952x53 3x32 22.296210.5903YesYes267
963x32 Lig 16.62946.49533YesYes270
971x57 2x40 10.21862.18233YesNo078
982x37 2x40 23.97983.62733YesNo088
992x40 I1x48 13.24732.48867NoNo086
1006x44 6x48 13.16038.59133YesYes399
1015x54 6x44 24.85316.68NoYes379
1025x54 5x58 24.77455.16033NoYes379
103G.H2.04 G.H2.07 50.24134.9YesYes199
104G.H3.08 G.S4.04 50.74315.71NoYes099
105b.l7x2 b.l9x6 12.00373.32133YesYes198
106b.b22x2 b.b26x3 11.98966.156NoYes086
107b.b20x5 b.b21x7 11.83945.07967NoYes075
108G.H3.17 b.l25x6 42.16733.43333YesNo148
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
7x34Lig5.594332NoYes5010
LigNT49.18932YesYes0301
1x28Lig6.8172NoYes4010
7x31Lig5.521330NoYes5010
E2Lig52.28372YesYes4010
E2x51Lig6.256672NoYes3010
E3Lig5.471332YesYes4010
7x24Lig2.415332NoYes7010
5x32Lig7.1952NoYes2010
NTNT11.11832YesYes3311
7x24NT4.489332NoYes7311
1x357x354.988670NoNo5521
2x533x3210.59032YesYes6721
2x537x427.778332YesYes6722
2x603x323.6632YesYes6711
2x63E1x507.409672YesYes5812
E1x49E24.689670NoYes4421
E1x50E25.2792YesYes8421
3x22E25.342NoYes4421
3x294x6510.66372NoNo5512
3x327x422.8032YesYes7712
4x64E212.70072NoYes4421
4x645x356.246672NoYes4222
4x65E2x523.486670NoYes5521
E2E254.43672YesYes4411
E2E2x517.157672YesNo4311
E2x51E2x523.605332NoYes3511
E2E2x523.390672YesYes4511
5x35E27.3972YesYes2421
5x36E24.3322NoYes4411
5x39E25.8130NoYes5421
5x32E23.769672NoYes2411
6x517x388.3740YesYes7621
6x547x343.5750NoNo5521
6x61E32.991332YesYes4411
6x64E32.824670NoYes1421
7x387x425.011672YesYes6712
2x562x603.1542NoYes6621
2x563x322.4272NoYes6721
2x602x633.3252YesYes6511
2x60Lig13.29272YesYes6010
2x63E22.877332YesYes5411
2x63Lig6.530672YesYes5010
3x29Lig4.4832NoYes5010
3x323x335.872672YesNo7512
3x32Lig6.495332YesYes7010
6x617x273.083332YesNo4411
6x61Lig4.1062YesYes4010
7x26E35.355332NoYes1421
7x27Lig3.642NoYes4010
7x35Lig3.777672NoYes5010
7x38Lig4.9332YesYes6010
E2x52Lig3.9982YesYes5010
3x327x383.892YesYes7611
5x36Lig2.6262NoYes4010
E3E33.0522YesYes4411
5x325x352.836672NoYes2212
5x336x622.2332NoNo1512
5x33Lig2.178672NoYes1010
1x27NT2.0462NoYes3321
6x617x302.033332YesYes4412
1x317x351.8960NoNo4521
1x251x281.4840NoNo4421
2x67Lig1.4340NoYes4010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
90.48Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
75.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
75.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
72.73Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
66.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
66.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
66.67Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
65.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
65.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
59.26Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
58.62Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
58.33Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
58.33Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
58.33Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
56.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
56.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
55.56Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
55.56Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
53.85Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
53.57Single7SK3CXCL127SK3-ACKR3-CXCL12
53.57Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
53.57Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
53.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
51.85Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
51.85Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
51.85Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
50.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
50.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
48.39Single6IGKEndothelin-36IGK-ETB-Endothelin-3
48.15Single3OE0CVX153OE0-CXCR4-CVX15
48.15Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
48.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
48.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
47.83Single7F1TMIP-1a7F1T-CCR5-MIP-1a
47.62Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
46.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
46.43Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
46.15Single8XWNCXCL88XWN-CXCR2-CXCL8
46.15Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
45.83Single6OS2TRV0266OS2-AT1-TRV026
45.83Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
44.44Single7SK5CXCL127SK5-ACKR3-CXCL12
44.44Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
44.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
44.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
44.00Single8ZPLHF511168ZPL-CXCR4-HF51116
44.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
43.75Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
43.75Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
43.75Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
43.48Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
43.48Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
43.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
43.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
42.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
42.86Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.86Consensusangiotensin_onOrthosteric Ligandat1_on
42.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.31Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
42.31Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
41.94Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
41.94Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
41.94Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
41.67Single6OS1TRV0266OS1-AT1-TRV026
41.67Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
41.67Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
41.67Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
41.38Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
41.38Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.38Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
41.38Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.38Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.38Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.38Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
41.18Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
40.91Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
40.91Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
40.74Single4XT1Fractalkine4XT1-US28-Fractalkine
40.62Single6IGLIRL16206IGL-ETB-IRL1620
40.62Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
40.62Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.62Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.62Consensusbradykinin_onOrthosteric Ligandbk2_on
40.62Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
40.62Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
40.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
40.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
40.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
40.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
40.00Single8XWACXCL18XWA-CXCR2-CXCL1
40.00Single8XWSCXCL58XWS-CXCR2-CXCL5
40.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
40.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
39.39Single5GLHEndothelin-15GLH-ETB-Endothelin-1
39.29Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
39.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
39.29Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
39.29Single7XNACYN1548067XNA-SST2-CYN154806
39.29Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
39.29Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
39.29Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
39.13Single6D27CAY104716D27-DP2-CAY10471
38.71Single4XT3Fractalkine4XT3-US28-Fractalkine
38.71Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
38.71Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
38.71Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
38.71Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
38.46Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
38.46Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
38.46Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
38.46Single8XVUCXCL28XVU-CXCR2-CXCL2
38.46Single8XWFCXCL38XWF-CXCR2-CXCL3
38.46Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
38.46Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
38.46Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.24Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
38.10Single3OE9IT1t3OE9-CXCR4-IT1t
37.93Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.93Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.93Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.93Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
37.50Single6D26Fevipiprant6D26-DP2-Fevipiprant
37.50Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
37.50Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
37.50Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
37.50Consensusdp_offOrthosteric Liganddp2_off
37.50Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
37.04Single6KNMJN241-96KNM-Apelin-JN241-9
37.04Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
37.04Single8XQJJN2418XQJ-Apelin-JN241
37.04Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
37.04Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
36.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
36.67Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.67Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
36.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
36.67Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
36.67Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
36.36Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
36.36Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
36.36Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
36.36Single8IY6Endothelin-18IY6-ETB-Endothelin-1
36.36Consensusendothelin_onOrthosteric Ligandetb_on eta_on
36.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
36.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
36.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
35.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
35.71Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
35.71Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
35.71Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
35.71Consensussomatostatin_offOrthosteric Ligandsst2_off
35.48Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
35.48Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
35.48Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
35.48Single8ZRTET-18ZRT-ETB-ET-1
35.48Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
35.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
35.48Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
34.78Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
34.78Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
34.78Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
34.78Single8ZPMAMD0708ZPM-CXCR4-AMD070
34.78Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
34.62Single4XEENeurotensin4XEE-NTS1-Neurotensin
34.62Single4XESNeurotensin4XES-NTS1-Neurotensin
34.62Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
34.62Single6YVRNTS8-136YVR-NTS1-NTS8-13
34.62Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
34.62Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
34.62Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
34.62Single8XQJJN2418XQJ-Apelin-JN241
34.62Single8XWMCXCL68XWM-CXCR2-CXCL6
34.62Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
34.62Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
34.62Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
34.62Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
34.48Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
34.48Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
34.48Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
34.48Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
34.48Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
34.48Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
34.48Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.48Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.48Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
34.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.38Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
34.38Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33Single3OE6IT1t3OE6-CXCR4-IT1t
33.33Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
33.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
33.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
33.33Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
33.33Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
33.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
33.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
32.35Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
32.26Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.26Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
32.26Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
32.26Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.26Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.26Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.26Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.26Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.26Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.26Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.26Consensusvasop-oxy_onOrthosteric Ligandv2_on
32.26Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
32.14Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
32.14Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
32.14Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
32.14Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
32.14Single8QJ2pN1628QJ2-MC4-pN162-Gs
32.14Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
32.14Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
32.14Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
32.14Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
32.14Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.14Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
32.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
32.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
32.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
31.82Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
31.82Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
31.43Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.25Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
31.25Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
31.25Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
31.25Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
31.25Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Single7F8XNN90567F8X-CCKA-NN9056
31.03Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
31.03Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
31.03Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
31.03Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.03Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
31.03Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.03Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
31.03Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
30.77Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
30.77Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.77Single7PX4PSB-21137PX4-A2A-PSB-2113
30.77Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
30.77Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
30.77Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
30.77Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.77Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
30.77Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.77Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.77Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.77Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.77Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
30.56Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
30.56Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.43Single3ODUIT1t3ODU-CXCR4-IT1t
30.43Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
30.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
30.43Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.43Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
30.43Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
30.43Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
30.43Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
30.43Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
30.43Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
30.43Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.43Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.30Single6FJ3PTH6FJ3-PTH1-PTH
30.30Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.30Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
30.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
30.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
30.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
30.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
30.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
30.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
30.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
30.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
29.63Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
29.63Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
29.63Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
29.63Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.63Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
29.63Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
29.63Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
29.63Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.63Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
29.63Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
29.63Consensuslpl_offOrthosteric Ligands1p_off lpa_off
29.63Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
29.63Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Consensusorexin_onOrthosteric Ligandox2_on
29.41Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
29.41Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
29.41Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
29.41Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
29.41Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
29.41Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
29.41Single9KDFRES-701-39KDF-ETB-RES-701-3
29.17Single7AROLUF58337ARO-A2A-LUF5833-Na
29.17Single7F61PF-036547467F61-H3-PF-03654746
29.17Single8IHKAcifran8IHK-HCA3-Acifran
29.17Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
29.17Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
29.17Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
29.17Single8K5CAcipimox8K5C-HCA2-Acipimox
29.17Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
29.17Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
29.17Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.17Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
29.17Consensushca_onOrthosteric Ligandhca2_on
29.03Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.03Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.03Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
29.03Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.03Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.03Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.03Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.57Single4BUONeurotensin4BUO-NTS1-Neurotensin
28.57Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.57Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
28.57Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
28.57Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
28.57Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
28.57Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
28.57Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
28.12Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.12Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
28.12Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.12Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
28.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
28.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
28.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
28.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
28.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
28.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
28.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
28.00Single8K5DGSK2560738K5D-HCA2-GSK256073
28.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
28.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
28.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
28.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
27.78Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
27.59Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.59Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
27.59Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
27.59Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
27.59Single7XN9L-054,5227XN9-SST2-L-054,522
27.59Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
27.59Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
27.59Single9IPYJR14a9IPY-C3aB-JR14a
27.59Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
27.59Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
27.59Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
27.27Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
27.27Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
27.27Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
27.27Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
27.27Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.27Consensuspac_onOrthosteric Ligandpac1_on
27.03Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
27.03Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
26.92Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.92Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.92Single5N2SPSB365N2S-A1-PSB36
26.92Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.92Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.92Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.92Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.92Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
26.92Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.92Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
26.92Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
26.92Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
26.92Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
26.92Single9EHSLUF76029EHS-A3A-LUF7602
26.92Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.92Consensusadenosine_offOrthosteric Liganda1_off a2_off
26.92Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.92Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.92Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
26.92Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
26.67Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
26.67Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
26.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
26.67Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
26.67Single8WDTphotoNECA8WDT-A2A-photoNECA
26.67Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
26.67Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
26.67Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.67Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.67Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.67Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
26.67Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
26.67Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.67Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.47Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
26.47Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
26.47Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.47Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
26.47Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
26.47Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
26.09Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
26.09Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
26.09Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.09Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
26.09Consensusgq_nucleotideOrthosteric Ligandgq_p2y
26.09Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.93Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
25.93Single4BV0Neurotensin4BV0-NTS1-Neurotensin
25.93Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.93Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.93Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
25.93Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.93Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
25.93Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
25.93Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
25.93Single8ZWFJR14a8ZWF-C3aB-JR14a
25.93Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
25.93Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
25.93Consensusneurotensin_onOrthosteric Ligandnts1_on
25.93Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.81Single3QAKUK-4320973QAK-A2A-UK-432097
25.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
25.81Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.81Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.71Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
25.64Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
25.64Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
25.64Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
25.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
25.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
25.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
25.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
25.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
25.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
24.32Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.32Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.32Consensusbombesin_onOrthosteric Ligandbb2_on
24.32Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
24.32Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.24Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
24.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
24.24Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
24.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
24.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
24.14Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
24.14Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
24.14Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
24.14Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
24.14Single7EZCUKA7EZC-A2A-UKA
24.14Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
24.14Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
24.14Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
24.14Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
24.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
24.14Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
24.14Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
24.14Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
24.14Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
24.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
24.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
24.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
24.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
24.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
24.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
24.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
24.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
24.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
24.00Single7T32ZM-2413857T32-A2A-ZM-241385
24.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
24.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
24.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
24.00Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
24.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
24.00Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
24.00Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
24.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
24.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.81Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
23.68Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
23.68Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
23.68Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.53Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
23.53Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.53Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.33Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
23.33Single5WF6UK-4320975WF6-A2A-UK-432097
23.33Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
23.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
23.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
23.33Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
23.33Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
23.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.33Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
23.08Single3EMLZM-2413853EML-A2A-ZM-241385
23.08Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
23.08Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.08Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
23.08Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
23.08Single5T04Neurotensin5T04-NTS1-Neurotensin
23.08Single5UENDU1725UEN-A1-DU172
23.08Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
23.08Single6S0LZM-2413856S0L-A2A-ZM-241385
23.08Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
23.08Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
23.08Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
23.08Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Single7PYRPSB-21157PYR-A2A-PSB-2115
23.08Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
23.08Single7V3ZCP559407V3Z-CB1-CP55940
23.08Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
23.08Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
23.08Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.08Single7YXAONO-54306087YXA-S1P5-ONO-5430608
23.08Single8CU6LJ-45178CU6-A2A-LJ-4517
23.08Single9H37A1IR09H37-A2A-A1IR0-Na
23.08Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
23.08Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
23.08Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
23.08Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.08Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
23.08Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
22.86Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.73Single3OE8IT1t3OE8-CXCR4-IT1t
22.73Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
22.58Single4IARErgotamine4IAR-5-HT1B-Ergotamine
22.58Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
22.58Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
22.58Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
22.58Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
22.58Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
22.58Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.58Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
22.58Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.58Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single4JKVTaladegib4JKV-SMO-Taladegib
22.22Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
22.22Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
22.22Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
22.22Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
22.22Single7C61Ergotamine7C61-5-HT1B-Ergotamine
22.22Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
22.22Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.22Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
22.22Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
22.22Single7W41PD1762527W41-BB2-PD176252
22.22Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8QOTNanobody-E8QOT-μ-Nanobody-E
22.22Single8TF5Oleic acid8TF5-GPR6-Oleic acid
22.22Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
22.22Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.22Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.22Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensusbombesin_offOrthosteric Ligandbb2_off
22.22Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.22Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.22Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.22Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.88Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
21.88Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
21.88Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
21.88Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
21.88Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
21.88Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
21.74Single4XNWMRS25004XNW-P2Y1-MRS2500
21.74Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
21.74Single8JPSCCL78JPS-ACKR1-CCL7
21.74Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
21.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
21.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
21.62Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
21.62Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
21.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
21.62Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
21.62Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
21.62Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
21.43Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.43Single5V56TC1145V56-SMO-TC114
21.43Single5V57TC1145V57-SMO-TC114
21.43Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.43Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.43Single7B6WCyclazosin7B6W-α1b-Cyclazosin
21.43Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.43Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
21.43Single7R0CAVP7R0C-V2-AVP-Arrestin2
21.43Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.43Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
21.43Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
21.43Single8E0GBU728E0G-μ-BU72
21.43Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
21.43Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
21.43Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
21.43Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
21.43Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
21.43Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.43Consensuslpa_onOrthosteric Ligandlpa1_on
21.43Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
21.43Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.43Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.21Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
21.21Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
21.21Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
21.21Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
21.21Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
21.05Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.05Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
20.93Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
20.93Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
20.83Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.83Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
20.83Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.83Single8K5BNiacin8K5B-HCA2-Niacin
20.83Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
20.83Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
20.83Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.83Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
20.69Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.69Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.69Single6A93Risperidone6A93-5-HT2A-Risperidone
20.69Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.69Single6MXTSalmeterol6MXT-β2-Salmeterol
20.69Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
20.69Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.69Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.69Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
20.69Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
20.69Single9BJKNAM9BJK-μ-Naloxone-NAM
20.69Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
20.69Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.69Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
20.69Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.69Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.69Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
20.69Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
20.69Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.69Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
20.69Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.69Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.69Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.69Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.69Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.69Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.59Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
20.59Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.59Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
20.59Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.59Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
20.59Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.59Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
20.51Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
20.51Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
20.00Single3PWHZM-2413853PWH-A2A-ZM-241385
20.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6IBLArformoterol6IBL-β1-Arformoterol
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
20.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
20.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
20.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
20.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
20.00Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
20.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
20.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
20.00Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
19.51Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
19.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.44Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
19.44Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
19.44Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
19.44Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
19.44Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
19.44Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
19.44Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
19.44Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
19.35Single4UG2CGS216804UG2-A2A-CGS21680
19.35Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
19.35Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
19.35Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
19.35Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
19.35Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
19.35Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
19.35Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
19.23Single3REYXAC3REY-A2A-XAC
19.23Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.23Single5JTBZM-2413855JTB-A2A-ZM-241385
19.23Single5UVIZM-2413855UVI-A2A-ZM-241385
19.23Single6AQFZM-2413856AQF-A2A-ZM-241385
19.23Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
19.23Single6V9SGTPL114036V9S-OX1-GTPL11403
19.23Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.23Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
19.23Single6ZG9GSK10347026ZG9-M1-GSK1034702
19.23Single6ZINSR486926ZIN-NTS1-SR48692
19.23Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
19.23Single7VV6C48/807VV6-MRGPRX2-C48/80
19.23Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
19.23Single8K2WAMG4878K2W-CXCR3-AMG487
19.23Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
19.23Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
19.23Single9BA0A1AKN9BA0-CB1-A1AKN
19.23Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
19.23Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
19.23Consensusa2_offOrthosteric Liganda2a_off
19.23Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
19.23Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.23Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.23Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.23Consensusgrh_offOrthosteric Ligandgnrh1_off
19.15Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
19.05Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.92Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
18.92Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
18.92Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
18.92Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
18.92Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.92Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
18.75Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
18.75Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
18.75Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.75Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
18.75Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
18.75Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.75Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
18.75Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
18.75Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
18.75Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
18.75Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
18.52Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
18.52Single4QIMANTA XV4QIM-SMO-ANTA XV
18.52Single4YAYZD-71554YAY-AT1-ZD-7155
18.52Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
18.52Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
18.52Single5TGZAM65385TGZ-CB1-AM6538
18.52Single5UIGCmpd-15UIG-A2A-Cmpd-1
18.52Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.52Single6GPSMK08126GPS-CCR2-MK0812
18.52Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
18.52Single6TOTLemborexant6TOT-OX1-Lemborexant
18.52Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
18.52Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
18.52Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
18.52Single7UL4Alvimopan7UL4-μ-Alvimopan
18.52Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
18.52Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
18.52Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
18.52Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
18.52Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
18.52Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
18.52Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
18.52Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.52Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
18.52Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
18.52Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
18.52Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
18.52Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
18.52Consensuscck_offOrthosteric Ligandccka_off
18.52Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
18.52Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
18.52Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.42Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
18.42Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.42Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
18.42Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
18.42Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
18.18Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
18.18Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.18Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.18Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
18.18Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.18Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
18.18Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.18Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.95Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
17.95Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
17.95Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
17.86Single2Y00Dobutamine2Y00-β1-Dobutamine
17.86Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
17.86Single5C1MBU725C1M-μ-BU72
17.86Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
17.86Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.86Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.86Single6GPXMK08126GPX-CCR2-MK0812
17.86Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.86Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
17.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.86Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
17.86Single6Z4SSR486926Z4S-NTS1-SR48692
17.86Single7C4SS1P7C4S-S1P3-S1P
17.86Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
17.86Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
17.86Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
17.86Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
17.86Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
17.86Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
17.86Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
17.86Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
17.86Single8JXSPF-61428JXS-D1-PF-6142
17.86Single8S4DCMF-0198S4D-Apelin-CMF-019
17.86Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
17.86Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
17.86Single9B9ZA1AKO9B9Z-CB1-A1AKO
17.86Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
17.86Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
17.86Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
17.86Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
17.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.86Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
17.86Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.86Consensusep_offOrthosteric Ligandep4_off
17.86Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.65Single6PT2KGCHM076PT2-δ-KGCHM07
17.65Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.65Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
17.65Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
17.65Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
17.50Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
17.50Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.50Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.39Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.39Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
17.39Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
17.39Consensusp2y_offOrthosteric Ligandp2y1_off
17.24Single3P0GBI1671073P0G-β2-BI167107
17.24Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.24Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
17.24Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
17.24Single5XR8AM8415XR8-CB1-AM841
17.24Single5XRAAM115425XRA-CB1-AM11542
17.24Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.24Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.24Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
17.24Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
17.24Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
17.24Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.24Single7FEECP559407FEE-CB1-CP55940-ZCZ011
17.24Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
17.24Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.24Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
17.24Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
17.24Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.24Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
17.24Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
17.24Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.24Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.24Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
17.24Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.24Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.24Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
17.24Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
17.24Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
17.24Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
17.24Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
17.24Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.24Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.24Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
17.24Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
17.24Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
17.24Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
17.14Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.14Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.14Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
17.14Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
17.07Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.07Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.67Single6KQICP559406KQI-CB1-CP55940-Org27569
16.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
16.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.67Single7DFPSpiperone7DFP-D2-Spiperone
16.67Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.67Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
16.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
16.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.67Single7YITNalfurafine7YIT-κ-Nalfurafine
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8JJ8Formoterol8JJ8-β2-Formoterol
16.67Single8JWY2-1188JWY-A2A-2-118
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
16.67Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
16.67Single8XYIVUF106618XYI-CXCR3-VUF10661
16.67Single9DGIZ85267113509DGI-CB1-Z8526711350
16.67Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
16.67Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.67Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.67Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
16.67Consensuscalcitonin_onOrthosteric Ligandctlike_on
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
16.67Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
16.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.28Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
16.22Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.22Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.22Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.22Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.22Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.22Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.22Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.22Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
16.22Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.13Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
16.13Single6H7LDobutamine6H7L-β1-Dobutamine
16.13Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.13Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
16.13Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.13Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.13Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.13Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
16.13Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
16.13Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
16.13Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
16.13Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
16.13Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
16.13Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Consensusendothelin_offOrthosteric Ligandetb_off
16.13Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
16.13Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
16.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.00Single5L7IVismodegib5L7I-SMO-Vismodegib
16.00Single6LI0C176LI0-GPR52-C17
16.00Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.00Single9B9Y7DY9B9Y-CB1-7DY
15.79Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
15.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
15.79Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
15.79Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.79Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.79Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.79Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
15.62Single3NY9ICI118-5513NY9-β2-ICI118-551
15.62Single5ZTYAM102575ZTY-CB2-AM10257
15.62Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
15.62Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
15.62Single8X5YAstemizole8X5Y-H1-Astemizole
15.62Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.62Single9JF4PD1683689JF4-BB1-PD168368
15.62Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
15.62Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
15.62Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.56Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
15.38Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
15.38Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
15.38Single4QINSAG1.54QIN-SMO-SAG1.5
15.38Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.38Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.38Single5U09Taranabant5U09-CB1-Taranabant
15.38Single5WS3EMPA5WS3-OX2-EMPA
15.38Single6AKYMaraviroc6AKY-CCR5-Maraviroc
15.38Single6DS0Ly2660976DS0-5-HT2B-Ly266097
15.38Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.38Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
15.38Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.38Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.38Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.38Single7F8ULintitript7F8U-CCKA-Lintitript
15.38Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
15.38Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.38Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
15.38Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
15.38Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.38Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
15.38Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.38Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.38Single8Y0HVUF114188Y0H-CXCR3-VUF11418
15.38Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
15.38Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
15.38Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
15.38Single9H2XA1IR19H2X-A2A-A1IR1-Na
15.38Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
15.38Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
15.38Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
15.38Consensusangiotensin_offOrthosteric Ligandat1_off
15.38Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.38Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.38Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
15.38Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.22Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.15Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
15.15Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.15Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
15.15Single7QA8Peptide7QA8-STE2-Peptide
15.15Single7QA8Peptide7QA8-STE2-Peptide
15.15Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
15.15Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.15Single8IEBA1LYA8IEB-GPR156-A1LYA
15.15Single8IEIA1LYA8IEI-GPR156-A1LYA
15.15Single8IEIA1LYA8IEI-GPR156-A1LYA
15.15Single8IEPA1LYA8IEP-GPR156-A1LYA
15.15Single8IEPA1LYA8IEP-GPR156-A1LYA
15.15Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.15Single8WKYPG-9348WKY-MC4-PG-934
15.15Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
15.15Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
15.15Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.15Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
15.15Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.15Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.15Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
15.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
14.81Single2YDOAdenosine2YDO-A2A-Adenosine
14.81Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
14.81Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.81Single4ZJCSB-6740424ZJC-OX1-SB-674042
14.81Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.81Single6IQLL7458706IQL-D4-L745870
14.81Single6KUXRS-799486KUX-α2a-RS-79948
14.81Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
14.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
14.81Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
14.81Single6TP3Nemorexant6TP3-OX1-Nemorexant
14.81Single6TPGEMPA6TPG-OX2-EMPA
14.81Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.81Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.81Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single7UL3Famotidine7UL3-H2-Famotidine
14.81Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
14.81Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
14.81Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
14.81Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
14.81Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
14.81Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.81Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
14.81Single8RLNLUF58348RLN-A2A-LUF5834
14.81Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.81Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
14.81Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
14.81Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
14.81Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
14.81Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.81Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.81Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
14.71Single6HLOAprepitant6HLO-NK1-Aprepitant
14.71Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
14.71Single8IEBA1LYA8IEB-GPR156-A1LYA
14.71Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single2Y01Dobutamine2Y01-β1-Dobutamine
14.29Single2Y02Carmoterol2Y02-β1-Carmoterol
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
14.29Single4QKX35V4QKX-β2-35V
14.29Single5DHGC-355DHG-NOP-C-35
14.29Single5DHHSB-6121115DHH-NOP-SB-612111
14.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.29Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
14.29Single6PS1Timolol6PS1-β2-Timolol
14.29Single6W25SHU91196W25-MC4-SHU9119-Ca
14.29Single7BU7BI1671077BU7-β1-BI167107
14.29Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
14.29Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
14.29Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
14.29Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
14.29Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.29Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
14.29Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
14.29Single8T1WCVN4248T1W-GPR6-CVN424
14.29Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
14.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
14.29Single9CHXS-Carazolol9CHX-β2-S-Carazolol
14.29Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
14.29Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
14.29Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
14.29Consensusa3_onOrthosteric Liganda3a_on
14.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
14.29Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
13.95Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.95Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
13.89Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.89Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.89Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.89Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.89Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.79Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
13.79Single5WIUNemonapride5WIU-D4-Nemonapride
13.79Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.79Single5WQCEMPA5WQC-OX2-EMPA
13.79Single6E67BI1671076E67-β2-BI167107-Gs(CT)
13.79Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.79Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.79Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
13.79Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
13.79Single6TP6Filorexant6TP6-OX1-Filorexant
13.79Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
13.79Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
13.79Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
13.79Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.79Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
13.79Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.79Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
13.79Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
13.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.79Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
13.79Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
13.79Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
13.79Consensusa3_on_gpOrthosteric Liganda3a_on_gp
13.79Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.79Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.79Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.79Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.79Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
13.79Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
13.79Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
13.79Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
13.79Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
13.79Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Consensustrace-amine_onOrthosteric Ligandta1_on
13.64Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.51Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.51Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.51Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33Single2YDVNECA2YDV-A2A-NECA
13.33Single4DJHJDTic4DJH-κ-JDTic
13.33Single4UHRCGS216804UHR-A2A-CGS21680
13.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
13.33Single5G53NECA5G53-A2A-NECA-Gs
13.33Single5TZRMK86665TZR-FFA1-MK8666
13.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
13.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
13.33Single6J20Aprepitant6J20-NK1-Aprepitant
13.33Single6J21Aprepitant6J21-NK1-Aprepitant
13.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.33Single6WGTLSD6WGT-5-HT2A-LSD
13.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
13.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
13.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
13.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
13.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
13.33Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
13.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
13.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
13.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
13.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
13.33Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
13.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.33Single8XVLZibotentan8XVL-ETA-Zibotentan
13.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
13.33Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
13.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.33Consensusa2_onOrthosteric Liganda2b_on
13.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
13.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
13.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.33Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
13.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.33Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
13.16Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.16Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
13.16Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.04Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.04Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.04Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.04Single8PWNTheophylline8PWN-A2A-Theophylline
12.90Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.90Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.90Single4AMIBucindolol4AMI-β1-Bucindolol
12.90Single4N4WSANT-14N4W-SMO-SANT-1
12.90Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.90Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.90Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
12.90Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
12.90Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.90Single6CM4Risperidone6CM4-D2-Risperidone
12.90Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.90Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.90Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.90Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
12.90Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.90Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.90Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.90Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
12.90Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.90Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
12.90Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.90Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
12.90Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
12.90Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Consensusalpha1_offOrthosteric Ligandalpha1a_off
12.90Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
12.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.82Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.82Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.82Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
12.50Single3RFMCaffeine3RFM-A2A-Caffeine
12.50Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
12.50Single5X93K-87945X93-ETB-K-8794
12.50Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.50Single6K1QIRL25006K1Q-ETB-IRL2500
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6TQ9SB-4081246TQ9-OX1-SB-408124
12.50Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.50Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.50Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
12.50Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
12.50Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.50Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.50Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
12.50Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
12.50Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
12.50Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
12.50Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.50Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.50Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
12.50Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
12.50Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
12.50Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
12.50Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.50Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.12Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.12Single7SK9CCX6627SK9-ACKR3-CCX662
12.12Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.12Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.12Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
12.12Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
12.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
12.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.76Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.76Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.76Single9M4TSilodosin9M4T-Alpha1A-Silodosin
11.63Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.54Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
11.54Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.54Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.54Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
11.54Single7UL2SR486927UL2-NTS1-SR48692-Na
11.54Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
11.54Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
11.54Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.54Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.54Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.54Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.54Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.54Consensusneurotensin_offOrthosteric Ligandnts1_off
11.54Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.43Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.36Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.11Single6AKXA4R6AKX-CCR5-A4R
11.11Single6B73MP11046B73-κ-MP1104
11.11Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
11.11Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.11Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.11Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
11.11Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single6TODEMPA6TOD-OX1-EMPA-Na
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.11Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.11Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.11Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
11.11Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
11.11Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
11.11Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
11.11Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
11.11Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
11.11Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
11.11Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
11.11Single8IWESpermidine8IWE-TA9-Spermidine
11.11Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
11.11Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.11Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
11.11Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
11.11Consensusalpha2_offOrthosteric Ligandalpha2c_off
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.81Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.81Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
10.71Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
10.71Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.71Single6PS0S-Carazolol6PS0-β2-S-Carazolol
10.71Single6PS4ICI118-5516PS4-β2-ICI118-551
10.71Single6PS5S-Propranolol6PS5-β2-S-Propranolol
10.71Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
10.71Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
10.71Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.71Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
10.71Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
10.71Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
10.71Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
10.71Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
10.71Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
10.71Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
10.71Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.71Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
10.71Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
10.71Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.71Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.71Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
10.71Single9AS5Mescaline9AS5-5-HT2A-Mescaline
10.71Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.71Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.71Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
10.71Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
10.53Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
10.34Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.34Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.34Single3NY8ICI118-5513NY8-β2-ICI118-551
10.34Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
10.34Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
10.34Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.34Single4GBRS-Carazolol4GBR-β2-S-Carazolol
10.34Single6H7MSalbutamol6H7M-β1-Salbutamol
10.34Single6IIVDaltroban6IIV-TXA2-Daltroban
10.34Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.34Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
10.34Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
10.34Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
10.34Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
10.34Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
10.34Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.34Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.34Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
10.34Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
10.34Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.34Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
10.34Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.34Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.34Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
10.34Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.34Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
10.34Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
10.34Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
10.34Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
10.34Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
10.34Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
10.34Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
10.34Single8JJOAlprenolol8JJO-β2-Alprenolol
10.34Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.34Single8JXRLSD8JXR-D1-LSD
10.34Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.34Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.34Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
10.34Single9AS1DMT9AS1-5-HT2A-DMT
10.34Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.34Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.34Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.34Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
10.34Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.34Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.34Consensusblt_onOrthosteric Ligandblt1_on
10.34Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.34Consensusdopamine_offOrthosteric Ligandd2_off d3_off
10.34Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
10.34Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
10.34Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.34Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.34Consensusleukotriene_onOrthosteric Ligandblt_on
10.34Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
10.26Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
10.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
10.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
10.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
10.00Single5TVNLSD5TVN-5-HT2B-LSD
10.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
10.00Single5XPRBosentan5XPR-ETB-Bosentan
10.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
10.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
10.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
10.00Single6PS6Timolol6PS6-β2-Timolol
10.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
10.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
10.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
10.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
10.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
10.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
10.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
10.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
10.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
10.00Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
10.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9HAPTolvaptan9HAP-V2-Tolvaptan
10.00Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
10.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
10.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
10.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
10.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
10.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
10.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
10.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
10.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
10.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
10.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
10.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.76Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.68Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
9.68Single5D5AS-Carazolol5D5A-β2-S-Carazolol
9.68Single5D5BS-Carazolol5D5B-β2-S-Carazolol
9.68Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.68Single6E59L-7607356E59-NK1-L-760735
9.68Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
9.68Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
9.68Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
9.68Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
9.68Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
9.68Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.68Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
9.68Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
9.68Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
9.68Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.68Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.68Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
9.68Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
9.68Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.68Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.68Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.68Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
9.68Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
9.68Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
9.68Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.68Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
9.68Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
9.68Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.68Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.68Consensustachykinin_offOrthosteric Ligandnk1_off
9.38Single3D4STimolol3D4S-β2-Timolol
9.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.38Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
9.38Single6IIURamatroban6IIU-TXA2-Ramatroban
9.38Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.38Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.38Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.38Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.38Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
9.38Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.38Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
9.38Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.38Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.38Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.38Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
9.38Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.09Single7UM4AS26747237UM4-5-HT5A-AS2674723
9.09Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
9.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
9.09Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.09Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.09Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.09Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single6PT3DPI-2876PT3-δ-DPI-287
8.82Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.82Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
8.82Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
8.70Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.70Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
8.57Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.33Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
8.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
8.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
8.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.00Consensussensory_onOrthosteric Ligandopsins_on
7.89Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7.69Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.69Single3UZAGTPL92363UZA-A2A-GTPL9236
7.69Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.69Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
7.69Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
7.69Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.69Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.69Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.69Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
7.69Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
7.69Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.69Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.69Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.69Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
7.69Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
7.69Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
7.69Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
7.69Single9LRCHistamine9LRC-H4-Histamine
7.69Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
7.69Consensus5ht2_onOrthosteric Ligand5ht2b_on
7.69Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69Consensusgi_sensoryOrthosteric Ligandgi_opsins
7.69Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
7.69Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
7.69Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
7.69Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.69Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.41Single3PBLEticlopride3PBL-D3-Eticlopride
7.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.41Single6HLLCP999946HLL-NK1-CP99994
7.41Single6TP4ACT-4622066TP4-OX1-ACT-462206
7.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.41Single7SRQLSD7SRQ-5-HT2B-LSD
7.41Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.41Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
7.41Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
7.41Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
7.41Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
7.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
7.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.41Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.41Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
7.41Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.41Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
7.41Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
7.41Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
7.41Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
7.41Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.41Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.41Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
7.41Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
7.41Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.41Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
7.14Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
7.14Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
7.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
7.14Single6ME2Ramelteon6ME2-MT1-Ramelteon
7.14Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
7.14Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
7.14Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.14Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
7.14Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
7.14Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
7.14Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
7.14Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
7.14Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
7.14Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
7.14Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
7.14Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
7.14Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
7.14Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
7.14Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.14Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
7.14Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.14Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
7.14Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
7.14Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.14Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
7.14Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
6.98Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
6.90Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.90Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.90Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.90Single6A94Zotepine6A94-5-HT2A-Zotepine
6.90Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.90Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
6.90Single6TPKRetosiban6TPK-OT-Retosiban
6.90Single6TPNHTL66416TPN-OX2-HTL6641
6.90Single6VI4JDTic6VI4-κ-JDTic
6.90Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
6.90Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
6.90Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
6.90Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.90Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.90Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.90Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
6.90Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
6.90Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
6.90Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
6.90Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
6.90Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.90Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.90Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
6.90Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
6.90Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.90Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
6.90Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
6.90Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.90Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.90Single9AS3LSD9AS3-5-HT2A-LSD
6.90Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
6.90Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
6.90Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
6.90Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.90Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
6.90Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.90Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.90Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.90Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.90Consensusopsins_offOrthosteric Ligandrhodopsin_off
6.90Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
6.90Consensussensory_offOrthosteric Ligandopsins_off
6.90Consensusvasop-oxy_offOrthosteric Ligandot_off
6.67Single4DAJTiotropium4DAJ-M3-Tiotropium
6.67Single4EJ4Naltrindole4EJ4-δ-Naltrindole
6.67Single4MQSIperoxo4MQS-M2-Iperoxo
6.67Single4U14Tiotropium4U14-M3-Tiotropium
6.67Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
6.67Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
6.67Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
6.67Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
6.67Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
6.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
6.67Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
6.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.67Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
6.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.67Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
6.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
6.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
6.67Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.67Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
6.67Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
6.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
6.67Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
6.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
6.67Single8X63Mepyramine8X63-H1-Mepyramine
6.67Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.67Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
6.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
6.67Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
6.67Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
6.67Single9JEAAtropine9JEA-M1-Atropine
6.67Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
6.67Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
6.67Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
6.67Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.67Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
6.67Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
6.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.67Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.67Consensusalpha2_onOrthosteric Ligandalpha2b_on
6.67Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
6.67Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.67Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
6.67Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
6.67Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
6.67Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
6.67Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
6.67Consensushistamine_offOrthosteric Ligandh1_off
6.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
6.67Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
6.45Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
6.45Single5CGCHTL142425CGC-mGlu5-HTL14242
6.45Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
6.45Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.45Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
6.45Single7WC6LSD7WC6-5-HT2A-LSD
6.45Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.45Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
6.45Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.45Single8ZMFA1L108ZMF-5-HT2C-A1L10
6.45Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
6.45Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
6.45Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
6.45Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
6.45Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
6.45Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
6.45Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.45Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
6.45Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
6.45Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
6.45Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
6.45Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
6.45Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single4U15Tiotropium4U15-M3-Tiotropium
6.25Single5V54Methiothepin5V54-5-HT1B-Methiothepin
6.25Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
6.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
6.25Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
6.25Single6OL9Tiotropium6OL9-M5-Tiotropium
6.25Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
6.25Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
6.25Single8EA0Iperoxo8EA0-M3-Iperoxo
6.25Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
6.25Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
6.25Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
6.25Consensus5ht1_offOrthosteric Ligand5ht1b_off
6.25Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
6.25Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
6.25Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
6.25Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
6.25Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
6.25Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
6.06Single5CXVTiotropium5CXV-M1-Tiotropium
6.06Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
6.06Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
6.06Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
5.88Single5CGDHTL142425CGD-mGlu5-HTL14242
5.88Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8XVJMacitentan8XVJ-ETA-Macitentan
5.88Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
5.71Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6D35Cholesterol6D35-SMO-Cholesterol
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.76Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.76Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.76Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.76Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.76Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.76Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.76Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.76Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.76Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.76Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.76Single7XW7K1-707XW7-TSH-K1-70
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.76Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.76Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.76Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.76Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.76Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.76Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.76Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.76Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.76Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.76Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.76Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.76Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.76Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.76Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.76Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8WVXNorrin8WVX-LGR4-Norrin
4.76Single8WVYNorrin8WVY-LGR4-Norrin
4.76Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.76Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.76Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.76Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.76Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.76Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.76Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.76Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.76Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.76Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.76Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9KHHNorrin9KHH-LGR4-Norrin
4.76Single9S37NB219S37-LGR4-NB21
4.76Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.55Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.55Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.35Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.35Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.35Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.17Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.17Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.17Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.17Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.17Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.00Single5L7DCholesterol5L7D-SMO-Cholesterol
4.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.00Single8HS2Fab0468HS2-GPR20-Fab046
4.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.85Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
3.85Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
3.85Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
3.85Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.85Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.70Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.70Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.70Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
3.70Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
3.70Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
3.70Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.70Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.70Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
3.70Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.70Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.70Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.57Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.57Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.57Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.57Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.57Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
3.57Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
3.57Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.57Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
3.57Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.57Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
3.57Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.57Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
3.57Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.57Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
3.57Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.57Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single9AS7Psilocin9AS7-5-HT2A-Psilocin
3.57Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.57Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
3.57Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.45Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.45Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.45Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.45Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
3.45Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.45Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
3.45Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
3.45Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.45Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.45Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.45Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
3.45Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
3.45Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.45Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
3.45Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
3.45Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.33Single3RZECidoxepin3RZE-H1-Cidoxepin
3.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
3.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
3.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
3.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
3.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.33Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
3.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
3.33Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
3.33Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
3.33Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
3.33Single9ARXSerotonin9ARX-5-HT2A-Serotonin
3.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
3.23Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.23Single5DSGTiotropium5DSG-M4-Tiotropium
3.23Single8X64Desloratadine8X64-H1-Desloratadine
3.23Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
3.23Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
3.12Single4NTJAZD12834NTJ-P2Y12-AZD1283
3.12Single6HLPNetupitant6HLP-NK1-Netupitant
3.12Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
3.12Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9HC04YI9HC0-mGlu5-4YI
3.03Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.03Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
3.03Single7P2L4YI7P2L-mGlu5-4YI
3.03Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.03Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single9AS9RS130-1809AS9-5-HT2A-RS130-180
3.03Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
2.70Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.56Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.56Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.50Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.33Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
ccr6_on_gp 6WWZ-CCR6-CCL20-Go/β1/γ2
ccr8_on_gp 8KFX-CCR8-LMD-009-Gi1/β1/γ2
8KFY-CCR8-ZK-756326-Gi1/β1/γ2
8U1U-CCR8-CCL1-Gi1/β1/γ2
ccr2_on_gp 7XA3-CCR2-CCL2-Gi1/β1/γ2
ccr1_on_gp 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
ccr5_on_gp 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
Net Summary
Imin 2.397
Number of Linked Nodes 937
Number of Links 1182
Number of Hubs 201
Number of Links mediated by Hubs 774
Number of Communities 21
Number of Nodes involved in Communities 272
Number of Links involved in Communities 418
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 1152905
Length Of Smallest Path 3
Average Path Length 27.4809
Length of Longest Path 63
Minimum Path Strength 0.132
Average Path Strength 5.23882
Maximum Path Strength 38.0579
Minimum Path Correlation 0.702333
Average Path Correlation 0.972766
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 46.076
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.1937
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
ccr_off_on_gpccr_on_gpccr_off
This network is also present in following consensuses:
IdComponents
chemokine_on_gpccr_on_gp
cxcr_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ccr_on_gp.zip



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