psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D1	L:L:P100	6.44	No	No	0	0	0
2	L:L:Q27	L:L:V2	4.3	No	No	0	0	0
3	L:L:S26	L:L:V3	3.23	No	No	0	0	0
4	L:L:M4	L:L:S25	3.07	No	No	0	0	0
5	L:L:Q6	L:L:W40	4.38	Yes	Yes	5	0	0
6	L:L:C93	L:L:Q6	6.1	No	Yes	5	0	0
7	L:L:G106	L:L:Q6	3.29	No	Yes	0	0	0
8	L:L:Q6	L:L:T107	9.92	Yes	No	0	0	0
9	L:L:L11	L:L:P8	8.21	No	No	0	0	0
10	L:L:E110	L:L:S10	4.31	No	No	0	0	0
11	L:L:L11	L:L:V13	2.98	No	Yes	0	0	0
12	L:L:E110	L:L:P12	7.86	No	No	0	0	0
13	L:L:Q17	L:L:V13	4.3	Yes	Yes	0	0	0
14	L:L:V13	L:L:V83	6.41	Yes	No	6	0	0
15	L:L:Q17	L:L:T14	8.5	Yes	No	0	0	0
16	L:L:P18	L:L:Q17	3.16	No	Yes	0	0	0
17	L:L:I21	L:L:W40	3.52	No	Yes	0	0	0
18	L:L:I21	L:L:T107	9.12	No	No	0	0	0
19	L:L:S22	L:L:T77	4.8	No	No	0	0	0
20	L:L:C23	L:L:W40	6.53	No	Yes	5	0	0
21	L:L:C23	L:L:C93	7.28	No	No	5	0	0
22	L:L:D75	L:L:R24	5.96	No	No	0	0	0
23	L:L:L29	L:L:S25	9.01	No	No	0	0	0
24	L:L:S25	L:L:T74	3.2	No	No	0	0	0
25	L:L:F76	L:L:L29	3.65	Yes	No	0	0	0
26	L:L:T32	L:L:Y31	8.74	No	Yes	0	0	0
27	L:L:D33	L:L:Y31	3.45	Yes	Yes	0	0	0
28	L:L:Y31	L:L:Y37	2.98	Yes	Yes	1	0	0
29	L:L:Y31	N:N:Y109	6.95	Yes	No	1	0	0
30	L:L:Y31	N:N:H110	7.62	Yes	Yes	1	0	0
31	L:L:T32	R:R:E31	4.23	No	No	0	0	5
32	L:L:D33	L:L:N35	4.04	Yes	No	0	0	0
33	L:L:N35	L:L:Y37	3.49	No	Yes	1	0	0
34	L:L:K55	L:L:N35	6.99	No	No	1	0	0
35	L:L:K55	L:L:Y37	3.58	No	Yes	1	0	0
36	L:L:T97	L:L:Y37	3.75	No	Yes	0	0	0
37	L:L:Y37	N:N:H110	17.42	Yes	Yes	1	0	0
38	L:L:Y37	N:N:Y111	3.97	Yes	Yes	1	0	0
39	L:L:L38	L:L:W40	3.42	No	Yes	0	0	0
40	L:L:F76	L:L:L38	6.09	Yes	No	0	0	0
41	L:L:F41	L:L:N39	10.87	Yes	No	1	0	0
42	L:L:M94	L:L:N39	7.01	Yes	No	1	0	0
43	L:L:I53	L:L:W40	8.22	No	Yes	0	0	0
44	L:L:L78	L:L:W40	15.94	No	Yes	0	0	0
45	L:L:C93	L:L:W40	13.06	No	Yes	5	0	0
46	L:L:F41	L:L:R51	5.34	Yes	Yes	1	0	0
47	L:L:F41	L:L:M94	6.22	Yes	Yes	1	0	0
48	L:L:F103	L:L:F41	4.29	Yes	Yes	1	0	0
49	L:L:L52	L:L:Q42	10.65	No	Yes	0	0	0
50	L:L:Q42	L:L:Y91	6.76	Yes	Yes	0	0	0
51	L:L:P49	L:L:Q43	15.79	No	No	0	0	0
52	L:L:Q43	L:L:Y92	4.51	No	Yes	0	0	0
53	L:L:Q43	N:N:Q39	11.52	No	No	0	0	0
54	L:L:E86	L:L:R44	4.65	No	Yes	0	0	0
55	L:L:P49	N:N:W116	8.11	No	Yes	0	0	0
56	L:L:R51	L:L:Y54	5.14	Yes	Yes	1	0	0
57	L:L:R51	N:N:D114	8.34	Yes	No	0	0	0
58	L:L:R51	R:R:D181	5.96	Yes	No	1	0	2
59	L:L:F67	L:L:L52	4.87	Yes	No	0	0	0
60	L:L:N58	L:L:Y54	8.14	No	Yes	0	0	0
61	L:L:Y54	R:R:D181	4.6	Yes	No	1	0	2
62	L:L:Y54	R:R:D182	16.09	Yes	No	0	0	6
63	L:L:F76	L:L:V56	3.93	Yes	No	0	0	0
64	L:L:N58	L:L:S57	4.47	No	No	0	0	0
65	L:L:R59	L:L:V63	3.92	No	No	0	0	0
66	L:L:D65	L:L:R59	9.53	No	No	0	0	0
67	L:L:D60	L:L:V63	7.3	No	No	0	0	0
68	L:L:P64	L:L:R66	8.65	No	Yes	0	0	0
69	L:L:R66	L:L:R82	3.2	Yes	No	0	0	0
70	L:L:E84	L:L:R66	3.49	No	Yes	3	0	0
71	L:L:D87	L:L:R66	10.72	No	Yes	3	0	0
72	L:L:F67	L:L:I80	7.54	Yes	No	3	0	0
73	L:L:D87	L:L:F67	4.78	No	Yes	3	0	0
74	L:L:F67	L:L:Y91	5.16	Yes	Yes	3	0	0
75	L:L:K79	L:L:S68	3.06	No	No	0	0	0
76	L:L:G73	L:L:S72	3.71	No	No	0	0	0
77	L:L:I80	L:L:Y91	3.63	No	Yes	3	0	0
78	L:L:D87	L:L:E84	5.2	No	No	3	0	0
79	L:L:F90	L:L:Y92	8.25	No	Yes	0	0	0
80	L:L:F90	L:L:K108	9.93	No	No	0	0	0
81	L:L:G106	L:L:Y92	5.79	No	Yes	0	0	0
82	L:L:Y92	N:N:I45	8.46	Yes	Yes	0	0	0
83	L:L:L101	L:L:M94	5.65	No	Yes	0	0	0
84	L:L:F103	L:L:M94	13.68	Yes	Yes	1	0	0
85	L:L:M94	N:N:M113	5.78	Yes	No	0	0	0
86	L:L:Q95	L:L:T97	9.92	No	No	0	0	0
87	L:L:N96	N:N:H99	8.93	No	Yes	0	0	0
88	L:L:H98	L:L:T97	10.95	No	No	0	0	0
89	L:L:W99	N:N:W47	6.56	Yes	Yes	0	0	0
90	L:L:W99	N:N:W50	5.62	Yes	Yes	1	0	0
91	L:L:W99	N:N:N59	7.91	Yes	No	1	0	0
92	L:L:W99	N:N:Y109	6.75	Yes	No	1	0	0
93	L:L:W99	R:R:F29	6.01	Yes	Yes	1	0	4
94	L:L:P100	N:N:W47	8.11	No	Yes	0	0	0
95	L:L:L101	N:N:W47	10.25	No	Yes	0	0	0
96	L:L:L101	N:N:H99	3.86	No	Yes	0	0	0
97	L:L:F103	N:N:I45	16.33	Yes	Yes	0	0	0
98	L:L:F103	N:N:W116	5.01	Yes	Yes	0	0	0
99	L:L:E110	L:L:K108	9.45	No	No	0	0	0
100	N:N:V2	N:N:Y27	6.31	No	Yes	0	0	0
101	N:N:Q3	N:N:S25	4.33	No	No	0	0	0
102	N:N:C22	N:N:L4	4.76	No	Yes	2	0	0
103	N:N:A24	N:N:L4	3.15	No	Yes	2	0	0
104	N:N:L4	N:N:Y27	4.69	Yes	Yes	2	0	0
105	N:N:C96	N:N:L4	3.17	Yes	Yes	2	0	0
106	N:N:Q6	N:N:W36	3.29	Yes	Yes	2	0	0
107	N:N:C96	N:N:Q6	4.58	Yes	Yes	2	0	0
108	N:N:G117	N:N:Q6	3.29	No	Yes	0	0	0
109	N:N:Q118	N:N:Q6	3.84	No	Yes	2	0	0
110	N:N:G119	N:N:Q6	6.58	No	Yes	2	0	0
111	N:N:Q6	N:N:T120	4.25	Yes	No	0	0	0
112	N:N:S21	N:N:S7	4.89	No	No	0	0	0
113	N:N:E10	N:N:K12	12.15	No	No	0	0	0
114	N:N:T123	N:N:V11	3.17	No	No	0	0	0
115	N:N:K12	N:N:V18	6.07	No	No	0	0	0
116	N:N:K13	N:N:P14	3.35	No	No	0	0	0
117	N:N:L83	N:N:V18	2.98	No	No	0	0	0
118	N:N:D82	N:N:K19	12.44	No	No	0	0	0
119	N:N:V20	N:N:W36	7.36	No	Yes	2	0	0
120	N:N:M81	N:N:V20	6.09	No	No	2	0	0
121	N:N:T120	N:N:V20	3.17	No	No	0	0	0
122	N:N:C22	N:N:W36	3.92	No	Yes	2	0	0
123	N:N:C22	N:N:C96	7.28	No	Yes	2	0	0
124	N:N:K23	N:N:T78	4.5	No	No	0	0	0
125	N:N:A24	N:N:Y27	4	No	Yes	2	0	0
126	N:N:G26	N:N:S25	3.71	No	No	0	0	0
127	N:N:Y27	N:N:Y32	2.98	Yes	Yes	2	0	0
128	N:N:R98	N:N:Y27	8.23	Yes	Yes	2	0	0
129	N:N:S31	N:N:T28	4.8	No	No	0	0	0
130	N:N:F29	N:N:I34	3.77	No	No	0	0	0
131	N:N:F29	N:N:T53	10.38	No	No	0	0	0
132	N:N:F29	N:N:S77	3.96	No	No	0	0	0
133	N:N:R74	N:N:T30	3.88	No	No	0	0	0
134	N:N:S31	R:R:F189	9.25	No	Yes	0	0	3
135	N:N:R98	N:N:Y32	8.23	Yes	Yes	2	0	0
136	N:N:I101	N:N:Y32	4.84	No	Yes	2	0	0
137	N:N:Y32	R:R:S178	6.36	Yes	No	2	0	1
138	N:N:G33	N:N:W50	4.22	No	Yes	0	0	0
139	N:N:A79	N:N:I34	3.25	No	No	0	0	0
140	N:N:C96	N:N:I34	3.27	Yes	No	0	0	0
141	N:N:S35	N:N:W47	8.65	No	Yes	0	0	0
142	N:N:S35	N:N:W50	3.71	No	Yes	1	0	0
143	N:N:H99	N:N:S35	5.58	Yes	No	1	0	0
144	N:N:M70	N:N:W36	4.65	No	Yes	0	0	0
145	N:N:M81	N:N:W36	12.8	No	Yes	2	0	0
146	N:N:C96	N:N:W36	13.06	Yes	Yes	2	0	0
147	N:N:I45	N:N:V37	3.07	Yes	No	0	0	0
148	N:N:E46	N:N:R38	11.63	No	Yes	0	0	0
149	N:N:M48	N:N:R38	6.2	Yes	Yes	7	0	0
150	N:N:R38	N:N:Y94	14.4	Yes	No	7	0	0
151	N:N:I45	N:N:Q39	6.86	Yes	No	0	0	0
152	N:N:Q39	N:N:Y95	5.64	No	Yes	0	0	0
153	N:N:A40	N:N:Q43	3.03	No	No	0	0	0
154	N:N:G44	N:N:Q43	6.58	No	No	0	0	0
155	N:N:G49	N:N:W47	8.44	No	Yes	0	0	0
156	N:N:G49	N:N:M48	3.49	No	Yes	0	0	0
157	N:N:M48	N:N:V64	3.04	Yes	No	0	0	0
158	N:N:M48	N:N:Y94	5.99	Yes	No	7	0	0
159	N:N:S52	N:N:W50	7.41	Yes	Yes	1	0	0
160	N:N:H99	N:N:W50	7.41	Yes	Yes	1	0	0
161	N:N:W50	R:R:P27	4.05	Yes	Yes	1	0	5
162	N:N:W50	R:R:F29	7.02	Yes	Yes	1	0	4
163	N:N:I51	N:N:M70	8.75	No	No	0	0	0
164	N:N:I51	N:N:T72	6.08	No	No	0	0	0
165	N:N:N55	N:N:S52	2.98	Yes	Yes	1	0	0
166	N:N:S52	N:N:T102	3.2	Yes	No	1	0	0
167	N:N:S52	N:N:Y107	5.09	Yes	Yes	1	0	0
168	N:N:T53	N:N:T72	9.42	No	No	0	0	0
169	N:N:T102	N:N:Y54	8.74	No	No	0	0	0
170	N:N:N55	N:N:N57	10.9	Yes	No	0	0	0
171	N:N:N55	N:N:Y107	5.81	Yes	Yes	1	0	0
172	N:N:N55	R:R:D193	6.73	Yes	No	0	0	1
173	N:N:N57	R:R:P27	4.89	No	Yes	0	0	5
174	N:N:R58	N:N:Y60	18.52	No	Yes	0	0	0
175	N:N:R58	R:R:M24	4.96	No	No	0	0	2
176	N:N:N59	R:R:E26	3.94	No	No	1	0	2
177	N:N:N59	R:R:P27	8.15	No	Yes	1	0	5
178	N:N:K63	N:N:V64	3.04	No	No	0	0	0
179	N:N:V64	N:N:V68	3.21	No	Yes	0	0	0
180	N:N:R67	N:N:S85	6.59	No	No	0	0	0
181	N:N:R67	N:N:R87	9.6	No	No	8	0	0
182	N:N:D90	N:N:R67	3.57	Yes	No	8	0	0
183	N:N:M81	N:N:V68	3.04	No	Yes	0	0	0
184	N:N:L83	N:N:V68	2.98	No	Yes	0	0	0
185	N:N:D82	N:N:T69	4.34	No	No	0	0	0
186	N:N:R84	N:N:T69	5.17	No	No	0	0	0
187	N:N:D73	N:N:T76	11.56	No	No	0	0	0
188	N:N:R74	R:R:N192	3.62	No	No	0	0	1
189	N:N:T76	N:N:T78	9.42	No	No	0	0	0
190	N:N:T78	N:N:Y80	12.48	No	No	0	0	0
191	N:N:D90	N:N:L86	4.07	Yes	No	0	0	0
192	N:N:L86	N:N:V124	4.47	No	No	0	0	0
193	N:N:D90	N:N:R87	4.76	Yes	No	8	0	0
194	N:N:D89	N:N:D90	6.65	No	Yes	0	0	0
195	N:N:T123	N:N:T91	6.28	No	No	0	0	0
196	N:N:T91	N:N:V124	3.17	No	No	0	0	0
197	N:N:V93	N:N:Y95	6.31	No	Yes	0	0	0
198	N:N:T121	N:N:V93	3.17	No	No	0	0	0
199	N:N:V122	N:N:Y94	3.79	No	No	0	0	0
200	N:N:W116	N:N:Y95	6.75	Yes	Yes	0	0	0
201	N:N:G119	N:N:Y95	5.79	No	Yes	0	0	0
202	N:N:A97	N:N:W116	6.48	No	Yes	0	0	0
203	N:N:D114	N:N:R98	5.96	No	Yes	0	0	0
204	N:N:R98	N:N:V115	7.85	Yes	No	0	0	0
205	N:N:G100	N:N:H99	3.18	No	Yes	0	0	0
206	N:N:I101	R:R:S178	4.64	No	No	2	0	1
207	N:N:T102	N:N:Y107	4.99	No	Yes	1	0	0
208	N:N:G103	R:R:F189	3.01	No	Yes	0	0	3
209	N:N:R105	R:R:D187	4.76	No	No	0	0	3
210	N:N:N106	N:N:Y108	8.14	No	Yes	0	0	0
211	N:N:N106	R:R:I185	5.66	No	No	0	0	3
212	N:N:N106	R:R:D187	12.12	No	No	0	0	3
213	N:N:Y107	R:R:F29	7.22	Yes	Yes	1	0	4
214	N:N:H110	N:N:Y108	6.53	Yes	Yes	0	0	0
215	N:N:Y108	R:R:R30	5.14	Yes	No	0	0	5
216	N:N:Y108	R:R:E32	10.1	Yes	No	0	0	4
217	N:N:Y109	R:R:F29	17.54	No	Yes	1	0	4
218	N:N:H110	N:N:Y111	11.98	Yes	Yes	1	0	0
219	N:N:Y111	R:R:D181	5.75	Yes	No	1	0	2
220	N:N:Y111	R:R:R183	3.09	Yes	No	0	0	3
221	N:N:M113	N:N:W116	3.49	No	Yes	0	0	0
222	N:N:G119	N:N:Q118	3.29	No	No	2	0	0
223	R:R:E26	R:R:P27	3.14	No	Yes	1	2	5
224	R:R:C274	R:R:C28	7.28	No	No	0	5	9
225	R:R:H281	R:R:R30	10.16	No	No	0	4	5
226	R:R:F36	R:R:N33	8.46	No	No	0	4	6
227	R:R:N33	R:R:N37	5.45	No	No	0	6	3
228	R:R:F36	R:R:F40	15	No	Yes	0	4	5
229	R:R:L41	R:R:N37	4.12	Yes	No	0	6	3
230	R:R:F40	R:R:I44	10.05	Yes	No	0	5	5
231	R:R:L41	R:R:Y45	9.38	Yes	Yes	0	6	7
232	R:R:A98	R:R:L41	3.15	No	Yes	0	5	6
233	R:R:P42	R:R:V99	3.53	No	No	0	5	4
234	R:R:I47	R:R:T43	3.04	No	No	0	4	4
235	R:R:F293	R:R:I44	5.02	Yes	No	0	5	5
236	R:R:L91	R:R:Y45	3.52	No	Yes	0	8	7
237	R:R:F292	R:R:Y45	6.19	No	Yes	0	7	7
238	R:R:F293	R:R:I48	8.79	Yes	No	9	5	7
239	R:R:C296	R:R:I48	4.91	Yes	No	9	7	7
240	R:R:F49	R:R:I53	10.05	No	No	0	6	5
241	R:R:F49	R:R:P92	5.78	No	No	0	6	9
242	R:R:C296	R:R:T51	6.76	Yes	No	0	7	5
243	R:R:I53	R:R:V88	3.07	No	No	0	5	6
244	R:R:G55	R:R:V54	3.68	No	No	0	8	4
245	R:R:L58	R:R:V54	2.98	No	No	0	5	4
246	R:R:N56	R:R:S81	2.98	No	No	0	9	9
247	R:R:D84	R:R:N56	6.73	Yes	No	0	9	9
248	R:R:R77	R:R:V59	3.92	No	No	0	8	8
249	R:R:S81	R:R:V59	6.46	No	No	0	9	8
250	R:R:I60	R:R:S81	3.1	No	No	0	7	9
251	R:R:L61	R:R:Y65	4.69	No	No	0	4	5
252	R:R:L61	R:R:Q66	6.65	No	No	0	4	4
253	R:R:D74	R:R:M63	6.93	Yes	No	0	8	6
254	R:R:G64	R:R:R70	4.5	No	No	0	2	6
255	R:R:D74	R:R:K67	6.91	Yes	No	0	8	6
256	R:R:D74	R:R:R70	5.96	Yes	No	0	8	6
257	R:R:L78	R:R:R70	4.86	No	No	0	5	6
258	R:R:M72	R:R:S71	4.6	No	No	0	6	7
259	R:R:M72	R:R:R148	6.2	No	Yes	0	6	6
260	R:R:L305	R:R:T73	4.42	Yes	No	0	6	7
261	R:R:E153	R:R:K75	6.75	No	No	0	7	6
262	R:R:I130	R:R:Y76	4.84	No	No	0	8	7
263	R:R:D133	R:R:Y76	11.49	No	No	0	8	7
264	R:R:A152	R:R:Y76	4	No	No	0	3	7
265	R:R:L305	R:R:R77	3.64	Yes	No	0	6	8
266	R:R:H79	R:R:I126	3.98	Yes	No	0	9	7
267	R:R:H79	R:R:Y157	3.27	Yes	No	0	9	7
268	R:R:H79	R:R:W161	6.35	Yes	No	0	9	9
269	R:R:D84	R:R:L80	6.79	Yes	No	10	9	9
270	R:R:L80	R:R:N298	4.12	No	Yes	10	9	9
271	R:R:C295	R:R:D84	6.22	No	Yes	0	9	9
272	R:R:D84	R:R:N298	6.73	Yes	Yes	10	9	9
273	R:R:F87	R:R:Y116	4.13	Yes	No	0	7	6
274	R:R:F87	R:R:S119	6.61	Yes	No	0	7	0
275	R:R:F292	R:R:F87	13.93	No	Yes	0	7	7
276	R:R:C295	R:R:F87	4.19	No	Yes	0	9	7
277	R:R:L91	R:R:V88	2.98	No	No	0	8	6
278	R:R:T90	R:R:W94	3.64	No	No	4	6	7
279	R:R:T90	R:R:V112	3.17	No	No	4	6	5
280	R:R:I115	R:R:T90	3.04	No	No	0	5	6
281	R:R:F104	R:R:F93	12.86	Yes	No	0	7	6
282	R:R:F93	R:R:V112	5.24	No	No	0	6	5
283	R:R:V112	R:R:W94	4.9	No	No	4	5	7
284	R:R:H113	R:R:W94	6.35	Yes	No	4	6	7
285	R:R:F104	R:R:V96	3.93	Yes	No	0	7	5
286	R:R:D97	R:R:W102	4.47	No	Yes	0	5	9
287	R:R:D97	R:R:R183	3.57	No	No	0	5	3
288	R:R:N101	R:R:Y103	9.3	No	No	0	4	3
289	R:R:N101	R:R:R183	14.46	No	No	0	4	3
290	R:R:F104	R:R:W102	12.03	Yes	Yes	0	7	9
291	R:R:C109	R:R:W102	3.92	No	Yes	11	9	9
292	R:R:C186	R:R:W102	20.89	No	Yes	11	9	9
293	R:R:F104	R:R:L108	6.09	Yes	No	0	7	5
294	R:R:K110	R:R:N106	8.39	No	No	0	7	3
295	R:R:N106	R:R:N176	4.09	No	No	0	3	4
296	R:R:N106	R:R:V177	4.43	No	No	0	3	4
297	R:R:C109	R:R:C186	7.28	No	No	11	9	9
298	R:R:D171	R:R:H113	7.56	Yes	Yes	4	4	6
299	R:R:H113	R:R:R188	3.39	Yes	No	4	6	5
300	R:R:D171	R:R:V114	4.38	Yes	No	0	4	5
301	R:R:F172	R:R:V114	5.24	No	No	0	4	5
302	R:R:L120	R:R:Y116	4.69	No	No	0	7	6
303	R:R:E288	R:R:Y116	3.37	No	No	0	5	6
304	R:R:T117	R:R:T168	3.14	No	No	0	5	6
305	R:R:D171	R:R:T117	5.78	Yes	No	0	4	5
306	R:R:L120	R:R:Y121	3.52	No	Yes	0	7	7
307	R:R:L167	R:R:Y121	5.86	No	Yes	12	5	7
308	R:R:Q202	R:R:Y121	3.38	No	Yes	12	3	7
309	R:R:H203	R:R:Y121	14.16	No	Yes	0	4	7
310	R:R:S122	R:R:W161	7.41	Yes	No	0	7	9
311	R:R:P211	R:R:V124	3.53	No	No	0	9	7
312	R:R:L125	R:R:V160	2.98	No	Yes	0	5	7
313	R:R:I126	R:R:V160	9.22	No	Yes	0	7	7
314	R:R:H294	R:R:L127	5.14	No	No	0	9	8
315	R:R:L127	R:R:Y302	9.38	No	No	0	8	9
316	R:R:A128	R:R:P211	3.74	No	No	0	7	9
317	R:R:F129	R:R:L151	3.65	No	No	0	5	4
318	R:R:F129	R:R:G159	3.01	No	No	0	5	3
319	R:R:F129	R:R:V160	5.24	No	Yes	0	5	7
320	R:R:I130	R:R:L305	4.28	No	Yes	0	8	6
321	R:R:I215	R:R:S131	4.64	No	No	0	7	9
322	R:R:C218	R:R:S131	5.16	No	No	0	6	9
323	R:R:D133	R:R:R134	3.57	No	No	0	8	9
324	R:R:D133	R:R:R148	11.91	No	Yes	0	8	6
325	R:R:V139	R:R:Y135	5.05	No	No	0	7	8
326	R:R:H140	R:R:L136	3.86	No	No	0	6	5
327	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
328	R:R:I138	R:R:I222	5.89	No	No	13	8	8
329	R:R:H140	R:R:V139	8.3	No	No	0	6	7
330	R:R:K225	R:R:V139	3.04	No	No	0	4	7
331	R:R:R148	R:R:S144	5.27	Yes	No	0	6	5
332	R:R:L151	R:R:V155	2.98	No	No	0	4	2
333	R:R:V156	R:R:Y157	3.79	No	No	0	5	7
334	R:R:V160	R:R:W161	7.36	Yes	No	0	7	9
335	R:R:I162	R:R:P163	3.39	No	No	0	4	4
336	R:R:L167	R:R:Q202	5.32	No	No	12	5	3
337	R:R:I169	R:R:P170	3.39	No	No	0	3	8
338	R:R:F199	R:R:P170	10.11	No	No	0	5	8
339	R:R:D171	R:R:R188	10.72	Yes	No	4	4	5
340	R:R:F174	R:R:I173	10.05	No	No	0	4	3
341	R:R:F174	R:R:Y190	8.25	No	Yes	0	4	4
342	R:R:F189	R:R:N176	6.04	Yes	No	0	3	4
343	R:R:F189	R:R:S178	5.28	Yes	No	0	3	1
344	R:R:E179	R:R:Y184	10.1	No	No	0	2	5
345	R:R:R188	R:R:Y190	9.26	No	Yes	0	5	4
346	R:R:V196	R:R:Y190	6.31	No	Yes	0	4	4
347	R:R:F199	R:R:Y190	12.38	No	Yes	0	5	4
348	R:R:P191	R:R:W195	8.11	No	No	0	5	5
349	R:R:D193	R:R:L266	8.14	No	No	0	1	3
350	R:R:Q200	R:R:V196	4.3	No	No	0	5	4
351	R:R:L266	R:R:V197	4.47	No	No	0	3	3
352	R:R:L267	R:R:V197	4.47	No	No	0	1	3
353	R:R:I259	R:R:Q200	6.86	No	No	0	5	5
354	R:R:Q200	R:R:S263	7.22	No	No	0	5	5
355	R:R:F201	R:R:S263	6.61	No	No	0	4	5
356	R:R:F201	R:R:F264	4.29	No	No	0	4	4
357	R:R:H203	R:R:Y256	9.8	No	Yes	0	4	8
358	R:R:I204	R:R:Y256	4.84	No	Yes	0	5	8
359	R:R:I204	R:R:I259	4.42	No	No	0	5	5
360	R:R:I204	R:R:S260	4.64	No	No	0	5	5
361	R:R:M205	R:R:V206	3.04	No	No	0	4	4
362	R:R:G207	R:R:V206	3.68	No	No	0	5	4
363	R:R:L208	R:R:L253	4.15	No	No	0	8	5
364	R:R:L208	R:R:Y256	11.72	No	Yes	0	8	8
365	R:R:L210	R:R:P211	3.28	No	No	0	6	9
366	R:R:F249	R:R:L216	3.65	Yes	No	0	4	4
367	R:R:C218	R:R:I222	3.27	No	No	0	6	8
368	R:R:T241	R:R:Y219	11.24	No	No	0	7	8
369	R:R:L244	R:R:Y219	3.52	No	No	0	7	8
370	R:R:H228	R:R:K225	3.93	No	No	0	5	4
371	R:R:K234	R:R:S227	4.59	No	No	0	7	4
372	R:R:K230	R:R:Q233	6.78	No	No	0	5	5
373	R:R:G231	R:R:K234	3.49	No	No	0	4	7
374	R:R:H232	R:R:R235	5.64	No	No	0	4	5
375	R:R:I243	R:R:K239	4.36	No	No	0	5	6
376	R:R:F304	R:R:T240	7.78	No	No	0	6	7
377	R:R:L244	R:R:Y302	8.21	No	No	0	7	9
378	R:R:F304	R:R:L244	4.87	No	No	0	6	7
379	R:R:F248	R:R:F249	4.29	No	Yes	0	9	4
380	R:R:F248	R:R:W252	8.02	No	Yes	0	9	9
381	R:R:F249	R:R:L253	9.74	Yes	No	0	4	5
382	R:R:W252	R:R:Y256	7.72	Yes	Yes	0	9	8
383	R:R:H294	R:R:W252	8.46	No	Yes	0	9	9
384	R:R:P254	R:R:W283	4.05	No	No	14	9	6
385	R:R:P254	R:R:T287	5.25	No	No	14	9	6
386	R:R:I259	R:R:Y255	12.09	No	No	0	5	7
387	R:R:E288	R:R:Y255	14.59	No	No	0	5	7
388	R:R:G258	R:R:I261	3.53	No	Yes	0	4	5
389	R:R:G258	R:R:I284	3.53	No	No	0	4	4
390	R:R:I261	R:R:V280	4.61	Yes	No	0	5	5
391	R:R:D262	R:R:H281	7.56	No	No	0	5	4
392	R:R:D262	R:R:I284	4.2	No	No	0	5	4
393	R:R:F264	R:R:I269	7.54	No	No	0	4	1
394	R:R:I265	R:R:I270	7.36	No	No	0	3	5
395	R:R:I270	R:R:Q272	5.49	No	No	0	5	2
396	R:R:C274	R:R:E277	4.56	No	No	0	5	2
397	R:R:E277	R:R:H281	6.15	No	No	0	2	4
398	R:R:I284	R:R:V280	3.07	No	No	0	4	5
399	R:R:T287	R:R:W283	8.49	No	No	14	6	6
400	R:R:I286	R:R:S285	3.1	No	No	0	6	5
401	R:R:C296	R:R:F293	5.59	Yes	Yes	9	7	5
402	R:R:H294	R:R:N298	20.41	No	Yes	0	9	9
403	R:R:L297	R:R:L301	4.15	No	Yes	0	6	7
404	R:R:I126	R:R:I130	2.94	No	No	0	7	8
405	R:R:I209	R:R:I213	2.94	No	No	0	4	3
406	R:R:A175	R:R:H113	2.93	No	Yes	0	4	6
407	R:R:I209	R:R:M205	2.92	No	No	0	4	4
408	R:R:D74	R:R:T73	2.89	Yes	No	0	8	7
409	R:R:F174	R:R:P191	2.89	No	No	0	4	5
410	R:R:W195	R:R:Y190	2.89	No	Yes	0	5	4
411	L:L:P45	L:L:R44	2.88	No	Yes	0	0	0
412	L:L:Q95	L:L:V2	2.87	No	No	0	0	0
413	R:R:Q202	R:R:V206	2.87	No	No	0	3	4
414	L:L:I80	L:L:L78	2.85	No	No	0	0	0
415	N:N:E10	N:N:V11	2.85	No	No	0	0	0
416	R:R:I115	R:R:L86	2.85	No	No	0	5	7
417	R:R:I138	R:R:L226	2.85	No	Yes	13	8	8
418	R:R:I162	R:R:L166	2.85	No	No	0	4	4
419	R:R:I209	R:R:L210	2.85	No	No	0	4	6
420	R:R:I222	R:R:L226	2.85	No	Yes	13	8	8
421	R:R:I223	R:R:L226	2.85	No	Yes	0	4	8
422	R:R:G258	R:R:W283	2.81	No	No	0	4	6
423	N:N:A92	N:N:R38	2.77	No	Yes	0	0	0
424	R:R:A289	R:R:F40	2.77	No	Yes	0	4	5
425	R:R:L132	R:R:L136	2.77	No	No	0	6	5
426	R:R:C218	R:R:Y135	2.69	No	No	0	6	8
427	N:N:Y111	R:R:A180	2.67	Yes	No	0	0	1
428	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
429	L:L:R66	L:L:S81	2.64	Yes	No	0	0	0
430	R:R:H79	R:R:K75	2.62	Yes	No	0	9	6
431	L:L:F76	L:L:T36	2.59	Yes	No	0	0	0
432	N:N:A61	N:N:W47	2.59	No	Yes	0	0	0
433	R:R:H140	R:R:N143	2.55	No	No	0	6	5
434	N:N:S21	N:N:Y80	2.54	No	No	0	0	0
435	L:L:V109	L:L:Y91	2.52	No	Yes	0	0	0
436	N:N:V68	N:N:Y60	2.52	Yes	Yes	0	0	0
437	L:L:I53	L:L:R59	2.51	No	No	0	0	0
438	R:R:F36	R:R:I286	2.51	No	No	0	4	6
439	R:R:F293	R:R:I47	2.51	Yes	No	0	5	4
440	R:R:I138	R:R:R134	2.51	No	No	0	8	9
441	R:R:F249	R:R:I245	2.51	Yes	No	0	4	7
442	R:R:F264	R:R:I270	2.51	No	No	0	4	5
443	N:N:T69	N:N:Y60	2.5	No	Yes	0	0	0
444	R:R:F40	R:R:L290	2.44	Yes	No	0	5	7
445	L:L:Q42	L:L:R44	2.34	Yes	Yes	0	0	0
446	L:L:Q42	L:L:R50	2.34	Yes	No	0	0	0
447	L:L:Q47	L:L:R44	2.34	No	Yes	0	0	0
448	R:R:L301	R:R:Y302	2.34	Yes	No	0	7	9
449	N:N:Q65	N:N:Y60	2.25	No	Yes	0	0	0
450	L:L:G104	L:L:G105	2.11	No	No	0	0	0
451	L:L:G105	L:L:G106	2.11	No	No	0	0	0
452	R:R:C296	R:R:G52	1.96	Yes	No	0	7	8
453	R:R:A307	R:R:G306	1.95	No	No	0	5	8
454	R:R:W102	R:R:Y184	1.93	Yes	No	0	9	5
455	N:N:A40	N:N:P41	1.87	No	No	0	0	0
456	N:N:A92	N:N:P41	1.87	No	No	0	0	0
457	L:L:G62	L:L:S61	1.86	No	No	0	0	0
458	L:L:G71	L:L:S70	1.86	No	No	0	0	0
459	L:L:G71	L:L:S72	1.86	No	No	0	0	0
460	N:N:G8	N:N:S7	1.86	No	No	0	0	0
461	L:L:G34	L:L:V30	1.84	No	No	0	0	0
462	N:N:G26	N:N:V2	1.84	No	No	0	0	0
463	L:L:G73	L:L:T74	1.82	No	No	0	0	0
464	N:N:G8	N:N:T120	1.82	No	No	0	0	0
465	L:L:P49	L:L:S48	1.78	No	No	0	0	0
466	L:L:G69	L:L:I53	1.76	No	No	0	0	0
467	N:N:T30	R:R:P191	1.75	No	No	0	0	5
468	N:N:G112	N:N:M113	1.75	No	No	0	0	0
469	L:L:G16	L:L:L15	1.71	No	No	0	0	0
470	N:N:G15	N:N:L86	1.71	No	No	0	0	0
471	R:R:A83	R:R:S122	1.71	No	Yes	0	8	7
472	R:R:A83	R:R:S123	1.71	No	No	0	8	9
473	R:R:A164	R:R:S122	1.71	No	Yes	0	7	7
474	R:R:A141	R:R:S144	1.71	No	No	0	8	5
475	R:R:G306	R:R:L305	1.71	No	Yes	0	8	6
476	L:L:A19	L:L:V13	1.7	No	Yes	6	0	0
477	L:L:A19	L:L:V83	1.7	No	No	6	0	0
478	N:N:G56	N:N:N55	1.7	No	Yes	0	0	0
479	N:N:A104	R:R:V196	1.7	No	No	0	0	4
480	R:R:A100	R:R:V99	1.7	No	No	0	5	4
481	R:R:A128	R:R:V214	1.7	No	No	0	7	6
482	L:L:D33	L:L:G34	1.68	Yes	No	0	0	0
483	N:N:A9	N:N:T121	1.68	No	No	0	0	0
484	L:L:L11	L:L:P12	1.64	No	No	0	0	0
485	L:L:G16	L:L:Q17	1.64	No	Yes	0	0	0
486	L:L:G46	L:L:Q47	1.64	No	No	0	0	0
487	N:N:G66	N:N:Q65	1.64	No	No	0	0	0
488	R:R:L41	R:R:P42	1.64	Yes	No	0	6	5
489	R:R:L136	R:R:P147	1.64	No	No	0	5	4
490	R:R:N56	R:R:P299	1.63	No	No	0	9	9
491	R:R:N298	R:R:P299	1.63	Yes	No	0	9	9
492	L:L:S26	L:L:V2	1.62	No	No	0	0	0
493	N:N:S125	N:N:V11	1.62	No	No	0	0	0
494	R:R:S122	R:R:V118	1.62	Yes	No	0	7	5
495	R:R:A237	R:R:I223	1.62	No	No	0	7	4
496	L:L:S20	L:L:T77	1.6	No	No	0	0	0
497	R:R:T241	R:R:V242	1.59	No	No	0	7	4
498	R:R:A247	R:R:L301	1.58	No	Yes	0	6	7
499	L:L:D33	R:R:A34	1.54	Yes	No	0	0	1
500	R:R:K230	R:R:S229	1.53	No	No	0	5	5
501	R:R:M63	R:R:V62	1.52	No	No	0	6	7
502	L:L:K79	L:L:T77	1.5	No	No	0	0	0
503	R:R:L78	R:R:V82	1.49	No	No	0	5	5
504	R:R:L86	R:R:V82	1.49	No	No	0	7	5
505	R:R:L165	R:R:V118	1.49	No	No	0	3	5
506	R:R:L150	R:R:V155	1.49	No	No	0	4	2
507	R:R:L238	R:R:V242	1.49	No	No	0	5	4
508	N:N:D73	N:N:S75	1.47	No	No	0	0	0
509	R:R:I257	R:R:I261	1.47	No	Yes	0	6	5
510	R:R:P147	R:R:R146	1.44	No	No	0	4	5
511	R:R:I53	R:R:L85	1.43	No	No	0	5	7
512	R:R:I60	R:R:L85	1.43	No	No	0	7	7
513	R:R:I243	R:R:L301	1.43	No	Yes	0	5	7
514	L:L:Q95	L:L:T102	1.42	No	No	0	0	0
515	R:R:G105	R:R:W102	1.41	No	Yes	0	8	9
516	R:R:K154	R:R:L150	1.41	No	No	0	3	4
517	R:R:K230	R:R:L226	1.41	No	Yes	0	5	8
518	N:N:N57	R:R:K25	1.4	No	No	0	0	4
519	R:R:E153	R:R:K149	1.35	No	No	0	7	6
520	N:N:R84	N:N:S17	1.32	No	No	0	0	0
521	R:R:E31	R:R:N278	1.31	No	No	0	5	3
522	R:R:C251	R:R:W252	1.31	No	Yes	0	8	9
523	L:L:R24	L:L:T74	1.29	No	No	0	0	0
524	N:N:Q62	N:N:Q65	1.28	No	No	0	0	0
525	R:R:F276	R:R:I261	1.26	No	Yes	0	1	5
526	R:R:F276	R:R:I265	1.26	No	No	0	1	3
527	N:N:T71	N:N:Y80	1.25	No	No	0	0	0
528	R:R:I221	R:R:Y135	1.21	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Q6	5.9225	4	5	0
2	L:L:V13	3.8475	4	6	0
3	L:L:Q17	4.4	4	0	0
4	L:L:Y31	5.948	5	1	0
5	L:L:D33	2.6775	4	0	0
6	L:L:Y37	5.865	6	1	0
7	L:L:W40	7.86714	7	5	0
8	L:L:F41	6.68	4	1	0
9	L:L:Q42	5.5225	4	0	0
10	L:L:R44	3.0525	4	0	0
11	L:L:R51	6.195	4	1	0
12	L:L:Y54	8.4925	4	1	0
13	L:L:R66	5.74	5	3	0
14	L:L:F67	5.5875	4	3	0
15	L:L:F76	4.065	4	0	0
16	L:L:Y91	4.5175	4	3	0
17	L:L:Y92	6.7525	4	0	0
18	L:L:M94	7.668	5	1	0
19	L:L:W99	6.57	5	1	0
20	L:L:F103	9.8275	4	1	0
21	N:N:L4	3.9425	4	2	0
22	N:N:Q6	4.305	6	2	0
23	N:N:Y27	5.242	5	2	0
24	N:N:Y32	5.6025	4	2	0
25	N:N:W36	7.51333	6	2	0
26	N:N:R38	8.75	4	7	0
27	N:N:I45	8.68	4	0	0
28	N:N:W47	7.43333	6	0	0
29	N:N:M48	4.68	4	7	0
30	N:N:W50	5.63429	7	1	0
31	N:N:S52	4.67	4	1	0
32	N:N:N55	5.624	5	1	0
33	N:N:Y60	6.4475	4	0	0
34	N:N:V68	2.9375	4	0	0
35	N:N:D90	4.7625	4	8	0
36	N:N:Y95	6.1225	4	0	0
37	N:N:C96	6.272	5	2	0
38	N:N:R98	7.5675	4	2	0
39	N:N:H99	5.792	5	1	0
40	N:N:Y107	5.7775	4	1	0
41	N:N:Y108	7.4775	4	0	0
42	N:N:H110	10.8875	4	1	0
43	N:N:Y111	5.492	5	1	0
44	N:N:W116	5.968	5	0	0
45	R:R:P27	5.0575	4	1	5
46	R:R:F29	9.4475	4	1	4
47	R:R:F40	7.565	4	0	5
48	R:R:L41	4.5725	4	0	6
49	R:R:Y45	5.44	4	0	7
50	R:R:D74	5.6725	4	0	8
51	R:R:H79	4.055	4	0	9
52	R:R:D84	6.6175	4	10	9
53	R:R:F87	7.215	4	0	7
54	R:R:W102	7.44167	6	11	9
55	R:R:F104	8.7275	4	0	7
56	R:R:H113	5.0575	4	4	6
57	R:R:Y121	6.73	4	12	7
58	R:R:S122	3.1125	4	0	7
59	R:R:R148	7.5725	4	0	6
60	R:R:V160	6.2	4	0	7
61	R:R:D171	7.11	4	4	4
62	R:R:F189	5.895	4	0	3
63	R:R:Y190	7.818	5	0	4
64	R:R:L226	2.49	4	13	8
65	R:R:F249	5.0475	4	0	4
66	R:R:W252	6.3775	4	0	9
67	R:R:Y256	8.52	4	0	8
68	R:R:I261	2.7175	4	0	5
69	R:R:F293	5.4775	4	9	5
70	R:R:C296	4.805	4	9	7
71	R:R:N298	8.2225	4	10	9
72	R:R:L301	2.375	4	0	7
73	R:R:L305	3.5125	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:W99	N:N:W47	32.9099	6.56	Yes	Yes	0	0	0
2	L:L:W99	N:N:Y109	39.2188	6.75	Yes	No	1	0	0
3	L:L:Y31	N:N:Y109	53.8247	6.95	Yes	No	1	0	0
4	L:L:Y31	L:L:Y37	27.7122	2.98	Yes	Yes	1	0	0
5	L:L:L101	L:L:M94	10.4304	5.65	No	Yes	0	0	0
6	L:L:F103	N:N:I45	33.1216	16.33	Yes	Yes	0	0	0
7	L:L:Y92	N:N:I45	36.836	8.46	Yes	Yes	0	0	0
8	L:L:G106	L:L:Y92	33.0715	5.79	No	Yes	0	0	0
9	L:L:G106	L:L:Q6	31.2638	3.29	No	Yes	0	0	0
10	L:L:Q6	L:L:W40	28.0404	4.38	Yes	Yes	5	0	0
11	L:L:F90	L:L:Y92	10.5783	8.25	No	Yes	0	0	0
12	L:L:Y31	N:N:H110	31.121	7.62	Yes	Yes	1	0	0
13	L:L:Y37	N:N:Y111	33.1868	3.97	Yes	Yes	1	0	0
14	N:N:H110	N:N:Y111	36.3074	11.98	Yes	Yes	1	0	0
15	L:L:L78	L:L:W40	13.2805	15.94	No	Yes	0	0	0
16	L:L:F41	L:L:R51	40.4878	5.34	Yes	Yes	1	0	0
17	L:L:I80	L:L:L78	12.604	2.85	No	No	0	0	0
18	L:L:F103	N:N:W116	10.3052	5.01	Yes	Yes	0	0	0
19	L:L:R51	N:N:D114	22.2565	8.34	Yes	No	0	0	0
20	L:L:R51	R:R:D181	55.3731	5.96	Yes	No	1	0	2
21	N:N:D114	N:N:R98	21.8781	5.96	No	Yes	0	0	0
22	N:N:R98	N:N:Y27	15.4816	8.23	Yes	Yes	2	0	0
23	N:N:G49	N:N:W47	31.815	8.44	No	Yes	0	0	0
24	N:N:G49	N:N:M48	31.0896	3.49	No	Yes	0	0	0
25	N:N:M48	N:N:V64	24.3147	3.04	Yes	No	0	0	0
26	N:N:V64	N:N:V68	22.9843	3.21	No	Yes	0	0	0
27	N:N:M81	N:N:V68	11.2335	3.04	No	Yes	0	0	0
28	N:N:M81	N:N:W36	10.2889	12.8	No	Yes	2	0	0
29	N:N:L4	N:N:Y27	14.904	4.69	Yes	Yes	2	0	0
30	N:N:C96	N:N:L4	11.3813	3.17	Yes	Yes	2	0	0
31	N:N:G119	N:N:Y95	17.8618	5.79	No	Yes	0	0	0
32	N:N:G119	N:N:Q6	16.6579	6.58	No	Yes	2	0	0
33	N:N:G8	N:N:T120	10.8601	1.82	No	No	0	0	0
34	N:N:L83	N:N:V68	16.1743	2.98	No	Yes	0	0	0
35	N:N:L83	N:N:V18	15.1822	2.98	No	No	0	0	0
36	N:N:K12	N:N:V18	14.1875	6.07	No	No	0	0	0
37	N:N:E10	N:N:K12	13.1903	12.15	No	No	0	0	0
38	N:N:E10	N:N:V11	12.1906	2.85	No	No	0	0	0
39	N:N:T123	N:N:V11	10.1837	3.17	No	No	0	0	0
40	N:N:V68	N:N:Y60	11.1884	2.52	Yes	Yes	0	0	0
41	N:N:Y111	R:R:R183	100	3.09	Yes	No	0	0	3
42	R:R:D97	R:R:R183	99.2634	3.57	No	No	0	5	3
43	R:R:D97	R:R:W102	99.0203	4.47	No	Yes	0	5	9
44	R:R:F104	R:R:W102	97.5546	12.03	Yes	Yes	0	7	9
45	R:R:F104	R:R:F93	96.7992	12.86	Yes	No	0	7	6
46	R:R:F93	R:R:V112	96.5462	5.24	No	No	0	6	5
47	R:R:V112	R:R:W94	53.2973	4.9	No	No	4	5	7
48	R:R:H113	R:R:W94	56.017	6.35	Yes	No	4	6	7
49	R:R:H113	R:R:R188	52.1535	3.39	Yes	No	4	6	5
50	R:R:R188	R:R:Y190	52.5719	9.26	No	Yes	0	5	4
51	N:N:H110	N:N:Y108	14.6435	6.53	Yes	Yes	0	0	0
52	N:N:Y108	R:R:R30	13.2379	5.14	Yes	No	0	0	5
53	R:R:H281	R:R:R30	13.0324	10.16	No	No	0	4	5
54	R:R:V196	R:R:Y190	46.0701	6.31	No	Yes	0	4	4
55	R:R:Q200	R:R:V196	45.6592	4.3	No	No	0	5	4
56	R:R:I259	R:R:Q200	53.4238	6.86	No	No	0	5	5
57	R:R:I259	R:R:Y255	22.1375	12.09	No	No	0	5	7
58	R:R:E288	R:R:Y255	21.684	14.59	No	No	0	5	7
59	R:R:E288	R:R:Y116	21.2555	3.37	No	No	0	5	6
60	R:R:F87	R:R:Y116	22.3805	4.13	Yes	No	0	7	6
61	R:R:F292	R:R:F87	19.4215	13.93	No	Yes	0	7	7
62	R:R:F292	R:R:Y45	18.7199	6.19	No	Yes	0	7	7
63	R:R:L41	R:R:Y45	17.8092	9.38	Yes	Yes	0	6	7
64	R:R:L41	R:R:N37	13.6688	4.12	Yes	No	0	6	3
65	R:R:N33	R:R:N37	12.8332	5.45	No	No	0	6	3
66	R:R:F36	R:R:N33	11.9951	8.46	No	No	0	4	6
67	R:R:T90	R:R:V112	42.9996	3.17	No	No	4	6	5
68	R:R:I115	R:R:T90	45.6141	3.04	No	No	0	5	6
69	R:R:I115	R:R:L86	45.0729	2.85	No	No	0	5	7
70	R:R:L86	R:R:V82	44.6319	1.49	No	No	0	7	5
71	R:R:L78	R:R:V82	44.2574	1.49	No	No	0	5	5
72	R:R:L78	R:R:R70	43.9404	4.86	No	No	0	5	6
73	R:R:D74	R:R:R70	43.3241	5.96	Yes	No	0	8	6
74	R:R:D74	R:R:T73	42.0914	2.89	Yes	No	0	8	7
75	R:R:L305	R:R:T73	41.8383	4.42	Yes	No	0	6	7
76	R:R:L305	R:R:R77	22.6974	3.64	Yes	No	0	6	8
77	R:R:R77	R:R:V59	22.388	3.92	No	No	0	8	8
78	R:R:S81	R:R:V59	22.1299	6.46	No	No	0	9	8
79	R:R:N56	R:R:S81	17.4183	2.98	No	No	0	9	9
80	R:R:I204	R:R:I259	31.4129	4.42	No	No	0	5	5
81	R:R:I204	R:R:Y256	30.6913	4.84	No	Yes	0	5	8
82	R:R:W252	R:R:Y256	20.4851	7.72	Yes	Yes	0	9	8
83	R:R:H294	R:R:W252	18.7274	8.46	No	Yes	0	9	9
84	R:R:H294	R:R:N298	13.4421	20.41	No	Yes	0	9	9
85	R:R:I130	R:R:L305	49.8584	4.28	No	Yes	0	8	6
86	R:R:I130	R:R:Y76	26.938	4.84	No	No	0	8	7
87	R:R:D133	R:R:Y76	25.3295	11.49	No	No	0	8	7
88	R:R:I126	R:R:I130	24.5214	2.94	No	No	0	7	8
89	R:R:H79	R:R:I126	11.0681	3.98	Yes	No	0	9	7
90	R:R:I126	R:R:V160	12.7618	9.22	No	Yes	0	7	7
91	R:R:S122	R:R:W161	10.2739	7.41	Yes	No	0	7	9
92	R:R:H294	R:R:L127	12.1317	5.14	No	No	0	9	8
93	R:R:L127	R:R:Y302	11.2886	9.38	No	No	0	8	9
94	R:R:D133	R:R:R134	19.6207	3.57	No	No	0	8	9
95	R:R:I138	R:R:R134	18.7951	2.51	No	No	0	8	9
96	R:R:I138	R:R:I222	12.8332	5.89	No	No	13	8	8
97	R:R:C218	R:R:I222	12.1004	3.27	No	No	0	6	8
98	R:R:D262	R:R:H281	12.4436	7.56	No	No	0	5	4
99	R:R:D262	R:R:I284	12.3184	4.2	No	No	0	5	4
100	R:R:F276	R:R:I261	12.3271	1.26	No	Yes	0	1	5
101	R:R:F276	R:R:I265	12.0152	1.26	No	No	0	1	3
102	R:R:I265	R:R:I270	11.712	7.36	No	No	0	3	5
103	R:R:F264	R:R:I270	11.1433	2.51	No	No	0	4	5
104	R:R:F201	R:R:F264	10.572	4.29	No	No	0	4	4
105	R:R:F201	R:R:S263	10.2939	6.61	No	No	0	4	5
106	L:L:F103	L:L:F41	36.3988	4.29	Yes	Yes	1	0	0
107	N:N:Y111	R:R:D181	57.0217	5.75	Yes	No	1	0	2
108	N:N:Y109	R:R:F29	14.2025	17.54	No	Yes	1	0	4
109	N:N:Q6	N:N:T120	10.6685	4.25	Yes	No	0	0	0
110	R:R:Q200	R:R:S263	10.6384	7.22	No	No	0	5	5
111	N:N:Q39	N:N:Y95	10.9528	5.64	No	Yes	0	0	0
112	R:R:D84	R:R:N56	11.9538	6.73	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T32	R:R:E31	4.23	0	No	No	0	5	0	1
L:L:R51	R:R:D181	5.96	1	Yes	No	0	2	0	1
L:L:Y54	R:R:D181	4.6	1	Yes	No	0	2	0	1
L:L:Y54	R:R:D182	16.09	1	Yes	No	0	6	0	1
L:L:W99	R:R:F29	6.01	1	Yes	Yes	0	4	0	1
N:N:S31	R:R:F189	9.25	0	No	Yes	0	3	0	1
N:N:Y32	R:R:S178	6.36	2	Yes	No	0	1	0	1
N:N:W50	R:R:P27	4.05	1	Yes	Yes	0	5	0	1
N:N:W50	R:R:F29	7.02	1	Yes	Yes	0	4	0	1
N:N:N55	R:R:D193	6.73	1	Yes	No	0	1	0	1
N:N:N57	R:R:P27	4.89	0	No	Yes	0	5	0	1
N:N:R58	R:R:M24	4.96	0	No	No	0	2	0	1
N:N:N59	R:R:E26	3.94	1	No	No	0	2	0	1
N:N:N59	R:R:P27	8.15	1	No	Yes	0	5	0	1
N:N:R74	R:R:N192	3.62	0	No	No	0	1	0	1
N:N:I101	R:R:S178	4.64	2	No	No	0	1	0	1
N:N:G103	R:R:F189	3.01	0	No	Yes	0	3	0	1
N:N:R105	R:R:D187	4.76	0	No	No	0	3	0	1
N:N:N106	R:R:I185	5.66	0	No	No	0	3	0	1
N:N:N106	R:R:D187	12.12	0	No	No	0	3	0	1
N:N:Y107	R:R:F29	7.22	1	Yes	Yes	0	4	0	1
N:N:Y108	R:R:R30	5.14	0	Yes	No	0	5	0	1
N:N:Y108	R:R:E32	10.1	0	Yes	No	0	4	0	1
N:N:Y109	R:R:F29	17.54	1	No	Yes	0	4	0	1
N:N:Y111	R:R:D181	5.75	1	Yes	No	0	2	0	1
N:N:Y111	R:R:R183	3.09	1	Yes	No	0	3	0	1
R:R:E26	R:R:P27	3.14	1	No	Yes	2	5	1	1
R:R:H281	R:R:R30	10.16	0	No	No	4	5	2	1
R:R:D97	R:R:R183	3.57	0	No	No	5	3	2	1
R:R:N101	R:R:R183	14.46	0	No	No	4	3	2	1
R:R:F174	R:R:Y190	8.25	0	No	Yes	4	4	2	2
R:R:F189	R:R:N176	6.04	0	Yes	No	3	4	1	2
R:R:F189	R:R:S178	5.28	0	Yes	No	3	1	1	1
R:R:V196	R:R:Y190	6.31	0	No	Yes	4	4	1	2
R:R:P191	R:R:W195	8.11	0	No	No	5	5	1	2
R:R:D193	R:R:L266	8.14	0	No	No	1	3	1	2
R:R:Q200	R:R:V196	4.3	0	No	No	5	4	2	1
R:R:F174	R:R:P191	2.89	0	No	No	4	5	2	1
R:R:W195	R:R:Y190	2.89	0	No	Yes	5	4	2	2
N:N:Y111	R:R:A180	2.67	1	Yes	No	0	1	0	1
N:N:T30	R:R:P191	1.75	0	No	No	0	5	0	1
N:N:A104	R:R:V196	1.7	0	No	No	0	4	0	1
L:L:D33	R:R:A34	1.54	0	Yes	No	0	1	0	1
N:N:N57	R:R:K25	1.4	0	No	No	0	4	0	1
R:R:E31	R:R:N278	1.31	0	No	No	5	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
66.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
41.67	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
37.50	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
36.84	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
36.84	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
36.84	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
31.58	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
30.00	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
29.41	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
29.41	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
29.41	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
28.57	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
28.57	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
27.78	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
27.78	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
27.27	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
26.67	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
26.67	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
26.32	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
25.00	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
25.00	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
25.00	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
25.00	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
25.00	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
23.81	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
23.53	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.53	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
23.53	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
23.53	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.08	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
22.73	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.73	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
21.74	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.74	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.74	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
21.74	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
21.74	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
21.74	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.43	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
21.43	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05	Single	8XQJ	JN241	8XQJ-Apelin-JN241
21.05	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
21.05	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
21.05	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.05	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
20.83	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
20.83	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
20.69	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
20.00	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
20.00	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
20.00	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.00	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.00	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
20.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.00	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.00	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
20.00	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
20.00	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
20.00	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
20.00	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
20.00	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
20.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
20.00	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
19.23	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
19.23	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
19.23	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
19.23	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
19.23	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.23	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
19.23	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
19.23	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
19.23	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
19.05	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
19.05	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
19.05	Single	8XQJ	JN241	8XQJ-Apelin-JN241
19.05	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
19.05	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
18.75	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
18.75	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.75	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
18.75	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.52	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
18.18	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
18.18	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
18.18	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
17.86	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.86	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
17.86	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
17.86	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
17.65	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
17.65	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
17.65	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
17.65	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
17.65	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
17.65	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
17.65	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
17.39	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
17.39	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
17.39	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
17.39	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
17.39	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
17.39	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.39	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
17.24	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.24	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
16.67	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
16.67	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
16.67	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.67	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
16.67	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
16.67	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
16.67	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
16.67	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
16.67	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
16.67	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
16.67	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
16.67	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
16.67	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
16.67	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
16.67	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
16.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
16.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
16.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.00	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
16.00	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
16.00	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
16.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
16.00	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
16.00	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
16.00	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
16.00	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
16.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
16.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
16.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
16.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
15.79	Single	5V56	TC114	5V56-SMO-TC114
15.79	Single	5V57	TC114	5V57-SMO-TC114
15.79	Single	6OS1	TRV026	6OS1-AT₁-TRV026
15.79	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
15.79	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
15.79	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
15.79	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
15.79	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
15.79	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
15.79	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
15.79	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.79	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.79	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
15.62	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
15.62	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
15.38	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
15.38	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.38	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
15.38	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
15.38	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
15.38	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
15.38	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
15.38	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
15.38	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
15.38	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.38	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
15.15	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
15.00	Single	6OS2	TRV026	6OS2-AT₁-TRV026
15.00	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
15.00	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
15.00	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
15.00	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
15.00	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.00	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.00	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
15.00	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
15.00	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
15.00	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
15.00	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
14.81	Single	6FJ3	PTH	6FJ3-PTH1-PTH
14.81	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
14.81	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
14.81	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
14.81	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
14.81	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
14.81	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
14.81	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
14.81	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
14.29	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
14.29	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
14.29	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
14.29	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
14.29	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
14.29	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
14.29	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
14.29	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
14.29	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
14.29	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
14.29	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.29	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
14.29	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
14.29	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
14.29	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
14.29	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
14.29	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
13.79	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.79	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.79	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
13.79	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
13.79	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
13.79	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
13.79	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
13.79	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
13.79	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
13.79	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
13.79	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
13.79	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
13.79	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
13.79	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
13.64	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
13.64	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
13.64	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
13.64	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
13.64	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
13.64	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
13.64	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
13.64	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.64	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
13.64	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
13.64	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
13.64	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
13.33	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
13.33	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
13.33	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
13.33	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
13.33	Single	6LI0	C17	6LI0-GPR52-C17
13.33	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
13.33	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
13.33	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
13.33	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.33	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
13.33	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
13.33	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
13.33	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.33	Single	9B9Y	7DY	9B9Y-CB₁-7DY
13.33	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
13.33	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
13.33	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
13.33	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
13.33	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
13.33	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
13.33	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
13.33	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
13.04	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
13.04	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
13.04	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
13.04	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
13.04	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
13.04	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
13.04	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
13.04	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
13.04	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
13.04	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
13.04	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.04	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
13.04	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
13.04	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
13.04	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.04	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
12.50	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
12.50	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
12.50	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
12.50	Single	5U09	Taranabant	5U09-CB₁-Taranabant
12.50	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
12.50	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
12.50	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
12.50	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
12.50	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
12.50	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
12.50	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
12.50	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
12.50	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
12.50	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
12.50	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.50	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
12.50	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
12.50	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
12.50	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
12.50	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
12.50	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
12.50	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
12.50	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
12.50	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
12.50	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
12.50	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
12.50	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
12.50	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
12.50	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
12.50	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
12.50	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
12.50	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
12.50	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
12.50	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
12.50	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
12.50	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
12.12	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.12	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
12.12	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
12.00	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
12.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
12.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
12.00	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
12.00	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
12.00	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
12.00	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
12.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.00	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.00	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
12.00	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
12.00	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
12.00	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
11.76	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
11.76	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
11.76	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
11.76	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
11.76	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
11.76	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
11.76	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.76	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
11.76	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
11.76	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
11.76	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
11.76	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
11.76	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
11.76	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
11.76	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
11.76	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
11.76	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
11.76	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.76	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
11.76	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
11.76	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
11.76	Consensus	hca_on	Orthosteric Ligand	hca2_on
11.76	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
11.76	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
11.54	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
11.54	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
11.54	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
11.54	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
11.54	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
11.54	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
11.54	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
11.54	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.54	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
11.54	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.54	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.54	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
11.54	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
11.54	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
11.54	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
11.54	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
11.54	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.54	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.54	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
11.54	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
11.54	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
11.11	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
11.11	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
11.11	Single	6D27	CAY10471	6D27-DP₂-CAY10471
11.11	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
11.11	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
11.11	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
11.11	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
11.11	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
11.11	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
11.11	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
11.11	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
11.11	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
11.11	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
11.11	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
11.11	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
11.11	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
11.11	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
11.11	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
11.11	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
11.11	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
11.11	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
11.11	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
11.11	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
11.11	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
11.11	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
11.11	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
11.11	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
11.11	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
11.11	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
11.11	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
11.11	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
11.11	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
11.11	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
11.11	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
11.11	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.11	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.11	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.11	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
11.11	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.11	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
11.11	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
11.11	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
11.11	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
11.11	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
11.11	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
11.11	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
11.11	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
11.11	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
11.11	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.11	Single	7XW7	K1-70	7XW7-TSH-K1-70
11.11	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
11.11	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
11.11	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
11.11	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
11.11	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
11.11	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
11.11	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
11.11	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
11.11	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
11.11	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
11.11	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
11.11	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
11.11	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
11.11	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
11.11	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
11.11	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
11.11	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
11.11	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
11.11	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
11.11	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
11.11	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
11.11	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
11.11	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
11.11	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
11.11	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
11.11	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
11.11	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
11.11	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
11.11	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
11.11	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
11.11	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
11.11	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
11.11	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
11.11	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
11.11	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
11.11	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
11.11	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
11.11	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
11.11	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
11.11	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
11.11	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
11.11	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
11.11	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
11.11	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
11.11	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
11.11	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
11.11	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
11.11	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
11.11	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
11.11	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
11.11	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
11.11	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
11.11	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
11.11	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8WVX	Norrin	8WVX-LGR4-Norrin
11.11	Single	8WVY	Norrin	8WVY-LGR4-Norrin
11.11	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
11.11	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
11.11	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
11.11	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
11.11	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
11.11	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
11.11	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
11.11	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
11.11	Single	9KHH	Norrin	9KHH-LGR4-Norrin
11.11	Single	9S37	NB21	9S37-LGR4-NB21
11.11	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
11.11	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
11.11	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
11.11	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
11.11	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
11.11	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
11.11	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
11.11	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
11.11	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
11.11	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
11.11	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
10.71	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.71	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
10.71	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.71	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.71	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.71	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
10.71	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
10.71	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.71	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
10.71	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.71	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
10.71	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
10.53	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
10.53	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
10.53	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
10.53	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
10.53	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
10.53	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
10.53	Single	7W41	PD176252	7W41-BB₂-PD176252
10.53	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
10.53	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
10.53	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
10.53	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
10.53	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.53	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
10.53	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
10.53	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
10.53	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
10.53	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
10.53	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
10.53	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
10.53	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
10.53	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
10.53	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
10.53	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
10.53	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
10.53	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
10.53	Consensus	dp_off	Orthosteric Ligand	dp2_off
10.53	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
10.53	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
10.53	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
10.34	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
10.34	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
10.34	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
10.34	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
10.34	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
10.34	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
10.34	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
10.34	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
10.34	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
10.34	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
10.34	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
10.34	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
10.34	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
10.34	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
10.00	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
10.00	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
10.00	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
10.00	Single	5TZR	MK8666	5TZR-FFA1-MK8666
10.00	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
10.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
10.00	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
10.00	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
10.00	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
10.00	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
10.00	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
10.00	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
10.00	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.00	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
10.00	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
10.00	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
10.00	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
10.00	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
10.00	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
10.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.00	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
10.00	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
10.00	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.00	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Single	9IK9	SST analogue	9IK9-SST1-SST analogue-Gi1/β1/γ2
10.00	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
10.00	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on adgrf_on adgrl_on adgre_on adgrd_on
10.00	Consensus	class-b2_on_gp	Orthosteric Ligand	adgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
10.00	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
10.00	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
10.00	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
10.00	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
10.00	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
10.00	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
10.00	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
10.00	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
10.00	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
10.00	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
10.00	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
10.00	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
9.68	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.68	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
9.68	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.68	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.52	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
9.52	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
9.52	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
9.52	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
9.52	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
9.52	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
9.52	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
9.52	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
9.52	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
9.52	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
9.52	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
9.52	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.52	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
9.52	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
9.52	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
9.52	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
9.52	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
9.52	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
9.52	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
9.52	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.52	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
9.52	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
9.52	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
9.52	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
9.52	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
9.52	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
9.52	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.52	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.52	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
9.52	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
9.52	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
9.52	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
9.52	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
9.52	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
9.52	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
9.52	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
9.52	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
9.52	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
9.52	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
9.52	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
9.52	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.52	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.38	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
9.38	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
9.38	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.38	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
9.38	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
9.38	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.38	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
9.09	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
9.09	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
9.09	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
9.09	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
9.09	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
9.09	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
9.09	Single	7EZC	UKA	7EZC-A_2A-UKA
9.09	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
9.09	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
9.09	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
9.09	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
9.09	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
9.09	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
9.09	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
9.09	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
9.09	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
9.09	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
9.09	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
9.09	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
9.09	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
9.09	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
9.09	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
9.09	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
9.09	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.09	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.09	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9M54	Neuropeptide VF	9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
9.09	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
9.09	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
9.09	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
9.09	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
9.09	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
9.09	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
9.09	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
9.09	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
9.09	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.09	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
9.09	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
8.82	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
8.82	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
8.82	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.82	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.82	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
8.82	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
8.70	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
8.70	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
8.70	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.70	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
8.70	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
8.70	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
8.70	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
8.70	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
8.70	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
8.70	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
8.70	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	9JF4	PD168368	9JF4-BB₁-PD168368
8.70	Single	9M0R	Neuropeptide VF	9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
8.70	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.70	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
8.70	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
8.70	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
8.70	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
8.70	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.70	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.57	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
8.33	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
8.33	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
8.33	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
8.33	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
8.33	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.33	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
8.33	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
8.33	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
8.33	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
8.33	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
8.33	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
8.33	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
8.33	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
8.33	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
8.33	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
8.33	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
8.33	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.33	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
8.33	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
8.33	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
8.33	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
8.33	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
8.33	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
8.33	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
8.33	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
8.33	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
8.33	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
8.33	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
8.33	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
8.33	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.33	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.33	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
8.33	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.11	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
8.00	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
8.00	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
8.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
8.00	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
8.00	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
8.00	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
8.00	Single	9E82	SDF-1-beta	9E82-ACKR3-SDF-1-β-Arrestin2
8.00	Single	9IK8	SST analogue	9IK8-SST1-SST analogue-Gi1/β1/γ2
8.00	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
8.00	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
8.00	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
8.00	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
8.00	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
8.00	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
8.00	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
8.00	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
8.00	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
8.00	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
7.89	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.69	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
7.69	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
7.69	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
7.69	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
7.69	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
7.69	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
7.69	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
7.69	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
7.69	Single	7V68	LY2119620	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
7.69	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
7.69	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.69	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.69	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
7.69	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.69	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
7.69	Single	8HS2	Fab046	8HS2-GPR20-Fab046
7.69	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
7.69	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
7.69	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.69	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.69	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
7.69	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
7.69	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
7.69	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
7.41	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
7.41	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
7.41	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
7.41	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
7.41	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
7.41	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7.41	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
7.41	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
7.41	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
7.41	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
7.41	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
7.41	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
7.41	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
7.14	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
7.14	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
7.14	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.14	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
7.14	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
7.14	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
7.14	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
7.14	Consensus	pac_on	Orthosteric Ligand	pac1_on
7.14	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.14	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.90	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
6.90	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.90	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
6.90	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
6.90	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
6.90	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.90	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
6.90	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
6.90	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
6.90	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
6.90	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.67	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.67	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.67	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
6.67	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
6.67	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.67	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
6.67	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.67	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.67	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.67	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
6.67	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
6.67	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
6.67	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
6.67	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.67	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.67	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
6.67	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
6.67	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.67	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
6.67	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.67	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
6.67	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.67	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.45	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
6.45	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
6.45	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.45	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
6.45	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
6.45	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
6.45	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.45	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
6.45	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.25	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
6.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
6.25	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
6.25	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
6.25	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.25	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.25	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.25	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.25	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.25	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.25	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
6.25	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.25	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
6.25	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
6.25	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
6.25	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
6.25	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
6.25	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
6.25	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
6.25	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
6.25	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
6.25	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
6.25	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.25	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8ZYU	Neurotensin peptide 8-13	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.25	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
6.25	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
6.25	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.25	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.25	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.06	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
6.06	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
6.06	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.06	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
6.06	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
5.88	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.88	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.88	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
5.88	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
5.88	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
5.88	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
5.88	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
5.88	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
5.88	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
5.88	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.88	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
5.88	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
5.88	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.88	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
5.88	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.88	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
5.88	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.88	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
5.88	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
5.88	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.88	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
5.88	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.88	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
5.88	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
5.88	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
5.88	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.88	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
5.88	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.88	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
5.88	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
5.88	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
5.88	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
5.88	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
5.88	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
5.88	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
5.88	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
5.88	Single	9H2X	A1IR1	9H2X-A_2A-A1IR1-Na
5.88	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
5.88	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.88	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.88	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
5.88	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.88	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.88	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
5.88	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
5.56	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.56	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.56	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
5.56	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
5.56	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
5.56	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
5.56	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
5.56	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
5.56	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
5.56	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
5.56	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
5.56	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
5.56	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
5.56	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
5.56	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.56	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.56	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
5.56	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.56	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.56	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
5.56	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
5.56	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
5.56	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
5.56	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
5.56	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
5.56	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.56	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.56	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
5.56	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
5.56	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
5.56	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
5.56	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.56	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.56	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.56	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
5.56	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.56	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
5.56	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.56	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
5.56	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
5.56	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
5.56	Single	8K9L	Damgo	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
5.56	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
5.56	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
5.56	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
5.56	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
5.56	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
5.56	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
5.56	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
5.56	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.56	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
5.56	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
5.56	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9IXX	LTD4	9IXX-CysLT₂-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
5.56	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
5.56	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
5.56	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
5.56	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.56	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
5.56	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
5.56	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.56	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.56	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
5.56	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.56	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.41	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.41	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.41	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.26	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.26	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
5.26	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
5.26	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.26	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
5.26	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
5.26	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
5.26	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
5.26	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.26	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.26	Single	5UEN	DU172	5UEN-A₁-DU172
5.26	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
5.26	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
5.26	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.26	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
5.26	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.26	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.26	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.26	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
5.26	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
5.26	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
5.26	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
5.26	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
5.26	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
5.26	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
5.26	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
5.26	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
5.26	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.26	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.26	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
5.26	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
5.26	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
5.26	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.26	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
5.26	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
5.26	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
5.26	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
5.26	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
5.26	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
5.26	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
5.26	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.26	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.26	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
5.26	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
5.26	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
5.26	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
5.26	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
5.26	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
5.26	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
5.26	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.26	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
5.26	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
5.26	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.26	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
5.26	Single	8T1W	CVN424	8T1W-GPR6-CVN424
5.26	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.26	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.26	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
5.26	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
5.26	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
5.26	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.26	Single	9H37	A1IR0	9H37-A_2A-A1IR0-Na
5.26	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
5.26	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
5.26	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
5.26	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.26	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.26	Consensus	a3_on	Orthosteric Ligand	a3a_on
5.26	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
5.26	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
5.26	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
5.26	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
5.00	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.00	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
5.00	Single	5C1M	BU72	5C1M-μ-BU72
5.00	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
5.00	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
5.00	Single	5N2S	PSB36	5N2S-A₁-PSB36
5.00	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
5.00	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
5.00	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
5.00	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
5.00	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.00	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
5.00	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
5.00	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
5.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.00	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
5.00	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
5.00	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
5.00	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
5.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.00	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
5.00	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
5.00	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
5.00	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
5.00	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
5.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
5.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
5.00	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
5.00	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
5.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
5.00	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
5.00	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.00	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.00	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
5.00	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
5.00	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
5.00	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
5.00	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
5.00	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
5.00	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
5.00	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
5.00	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.00	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
5.00	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
5.00	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.00	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.00	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
5.00	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.00	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.00	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.00	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
5.00	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
5.00	Consensus	ep_off	Orthosteric Ligand	ep4_off
5.00	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.00	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
5.00	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
5.00	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
5.00	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
4.76	Single	2YDV	NECA	2YDV-A_2A-NECA
4.76	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
4.76	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
4.76	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.76	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.76	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.76	Single	5XR8	AM841	5XR8-CB₁-AM841
4.76	Single	5XRA	AM11542	5XRA-CB₁-AM11542
4.76	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.76	Single	6E59	L-760735	6E59-NK₁-L-760735
4.76	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.76	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.76	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
4.76	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
4.76	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.76	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
4.76	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.76	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
4.76	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.76	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
4.76	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.76	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
4.76	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
4.76	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
4.76	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
4.76	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
4.76	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
4.76	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
4.76	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
4.76	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.76	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
4.76	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
4.76	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
4.76	Single	8E0G	BU72	8E0G-μ-BU72
4.76	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
4.76	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
4.76	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
4.76	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.76	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
4.76	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
4.76	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
4.76	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
4.76	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
4.76	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
4.76	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
4.76	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
4.76	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.76	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
4.76	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
4.76	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
4.76	Single	9EGO	YVF	9EGO-CB₁-YVF-Gi1/β1/γ2
4.76	Single	9I54	A1IZV	9I54-D₁-A1IZV-Gs/β1/γ2
4.76	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
4.76	Consensus	a2_on	Orthosteric Ligand	a2b_on
4.76	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
4.76	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.76	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.76	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
4.76	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
4.76	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
4.76	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
4.76	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
4.76	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.76	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.76	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.76	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.76	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.76	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
4.65	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
4.55	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.55	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.55	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.55	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
4.55	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.55	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
4.55	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
4.55	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
4.55	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
4.55	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.55	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
4.55	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.55	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
4.55	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.55	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.55	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
4.55	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
4.55	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
4.55	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.55	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.55	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
4.55	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
4.55	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.55	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
4.55	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.55	Single	8JWY	2-118	8JWY-A_2A-2-118
4.55	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.55	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
4.55	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
4.55	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.55	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.55	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.55	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.55	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.55	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
4.55	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
4.55	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.55	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.55	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
4.55	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.55	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
4.55	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.55	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.55	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.55	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.55	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.55	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
4.55	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.55	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.35	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.35	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.35	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
4.35	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.35	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.35	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.35	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.35	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.35	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
4.35	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
4.35	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.35	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.35	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.35	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.35	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
4.35	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
4.35	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.35	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
4.35	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
4.35	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.35	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.35	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
4.35	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.35	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
4.35	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
4.35	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
4.35	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.35	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
4.35	Single	9M1H	Prostaglandin E2	9M1H-EP₁-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.35	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.35	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
4.35	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.35	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.35	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
4.17	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.17	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.17	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
4.17	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.17	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
4.17	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
4.17	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
4.17	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
4.17	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.17	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
4.17	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.17	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
4.17	Single	8Y72	Peptide	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
4.17	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
4.17	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.17	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.17	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.17	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
4.17	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
4.00	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.00	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.00	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
4.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
4.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
4.00	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
4.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
4.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
4.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.00	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
4.00	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
4.00	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
4.00	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
4.00	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
4.00	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
3.85	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.85	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
3.85	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
3.85	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.85	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.85	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.85	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
3.70	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
3.70	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
3.70	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
3.70	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
3.70	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
3.70	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
3.70	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.70	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.57	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
3.57	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
3.45	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
3.45	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.45	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.45	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.45	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.33	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
3.33	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
3.33	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
3.23	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
3.23	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.23	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
3.23	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.23	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.23	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
3.23	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.23	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
3.12	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.12	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.12	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.03	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.03	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.03	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2

PDB Summary
PDB	8U4T
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR4
Species	Homo Sapiens
Ligand	REGN7663-Fab
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.38
Date	2024-03-13
D.O.I.	doi.org/10.1038/s41594-024-01397-1

Net Summary
I_min	2.98
Number of Linked Nodes	475
Number of Links	528
Number of Hubs	73
Number of Links mediated by Hubs	271
Number of Communities	14
Number of Nodes involved in Communities	84
Number of Links involved in Communities	107

Path Summary
Number Of Nodes in MetaPath	113
Number Of Links MetaPath	112
Number of Shortest Paths	165712
Length Of Smallest Path	3
Average Path Length	21.123
Length of Longest Path	50
Minimum Path Strength	1.26
Average Path Strength	5.91774
Maximum Path Strength	16.46
Minimum Path Correlation	0.7
Average Path Correlation	0.957963
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.4351
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.3281
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • protein binding • binding • myosin binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • cellular process • apoptotic process • cell death • programmed cell death • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • cellular response to stimulus • chemotaxis • dendritic cell chemotaxis • response to stimulus • response to external stimulus • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • taxis • immune system process • response to chemical • mononuclear cell migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • neurogenesis • cellular developmental process • cell differentiation • regulation of response to external stimulus • regulation of chemotaxis • regulation of response to stimulus • regulation of locomotion • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • signaling • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • C-X-C chemokine receptor CXCR4 signaling pathway • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • regulation of multicellular organismal development • regulation of developmental process • positive regulation of biological process • vasculature development • regulation of vasculature development • circulatory system development • positive regulation of developmental process • positive regulation of vasculature development • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • positive regulation of response to stimulus • macrophage migration inhibitory factor signaling pathway • positive regulation of cellular process • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • positive regulation of nervous system development • cell development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell leading edge • intracellular anatomical structure • cytoplasm • anchoring junction • cell junction • intracellular organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein-containing complex • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • endomembrane system • late endosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8U4T_Chain_R M K E P C F R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	doi.org/10.1016/j.celrep.2025.115255
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	Gi1/β1/γ2	2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ2	3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	Gi1/β1/γ2	3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.1	2024-03-13	doi.org/10.1101/2024.02.09.579708
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	doi.org/10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	doi.org/10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	doi.org/10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	doi.org/10.1126/science.1261064
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	-	-	3.01	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	-	-	3.2	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122

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