psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E26	R:R:P27	4.72	No	No	0	2	5
2	R:R:C274	R:R:C28	7.28	No	No	0	5	9
3	R:R:N33	R:R:N37	6.81	No	Yes	2	6	3
4	R:R:K38	R:R:N33	4.2	No	No	0	4	6
5	R:R:A34	R:R:N37	4.69	No	Yes	0	1	3
6	R:R:K38	R:R:N35	4.2	No	No	0	4	3
7	R:R:F36	R:R:F40	7.5	No	No	0	4	5
8	R:R:F40	R:R:I44	11.3	No	No	0	5	5
9	R:R:L41	R:R:Y45	4.69	Yes	Yes	2	6	7
10	R:R:A98	R:R:L41	3.15	No	Yes	2	5	6
11	R:R:A289	R:R:I44	3.25	No	No	0	4	5
12	R:R:F293	R:R:I44	6.28	No	No	0	5	5
13	R:R:L91	R:R:Y45	3.52	Yes	Yes	2	8	7
14	R:R:W94	R:R:Y45	2.89	Yes	Yes	2	7	7
15	R:R:A95	R:R:Y45	4	No	Yes	0	7	7
16	R:R:A98	R:R:Y45	2.67	No	Yes	2	5	7
17	R:R:F292	R:R:Y45	6.19	Yes	Yes	2	7	7
18	R:R:I48	R:R:L91	2.85	Yes	Yes	0	7	8
19	R:R:F292	R:R:I48	3.77	Yes	Yes	0	7	7
20	R:R:F293	R:R:I48	5.02	No	Yes	0	5	7
21	R:R:C296	R:R:I48	8.18	No	Yes	0	7	7
22	R:R:F49	R:R:L50	3.65	No	No	0	6	5
23	R:R:F49	R:R:I53	5.02	No	No	0	6	5
24	R:R:F49	R:R:P92	8.67	No	No	0	6	9
25	R:R:C296	R:R:T51	6.76	No	No	0	7	5
26	R:R:I53	R:R:V88	4.61	No	No	0	5	6
27	R:R:G55	R:R:P299	4.06	No	No	0	8	9
28	R:R:N56	R:R:S81	2.98	Yes	No	0	9	9
29	R:R:D84	R:R:N56	5.39	Yes	Yes	0	9	9
30	R:R:L85	R:R:N56	2.75	No	Yes	0	7	9
31	R:R:N56	R:R:P299	6.52	Yes	No	0	9	9
32	R:R:S81	R:R:V59	4.85	No	No	0	9	8
33	R:R:V59	R:R:Y302	5.05	No	No	0	8	9
34	R:R:I60	R:R:L78	2.85	No	No	0	7	5
35	R:R:I60	R:R:V82	3.07	No	No	0	7	5
36	R:R:L61	R:R:Q66	2.66	No	No	0	4	4
37	R:R:K68	R:R:V62	3.04	Yes	No	0	6	7
38	R:R:K68	R:R:M63	2.88	Yes	Yes	0	6	6
39	R:R:L69	R:R:M63	2.83	No	Yes	6	6	6
40	R:R:D74	R:R:M63	4.16	No	Yes	6	8	6
41	R:R:M63	R:R:Y302	5.99	Yes	No	0	6	9
42	R:R:K68	R:R:Q66	8.14	Yes	No	0	6	4
43	R:R:K67	R:R:K68	2.87	No	Yes	0	6	6
44	R:R:D74	R:R:L69	2.71	No	No	6	8	6
45	R:R:D74	R:R:S71	5.89	No	No	0	8	7
46	R:R:D133	R:R:M72	2.77	Yes	No	0	8	6
47	R:R:K149	R:R:M72	2.88	No	No	0	6	6
48	R:R:I130	R:R:T73	3.04	No	No	0	8	7
49	R:R:E153	R:R:K75	5.4	No	No	0	7	6
50	R:R:F129	R:R:Y76	4.13	Yes	Yes	0	5	7
51	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
52	R:R:D133	R:R:Y76	5.75	Yes	Yes	0	8	7
53	R:R:A152	R:R:Y76	2.67	No	Yes	0	3	7
54	R:R:V156	R:R:Y76	3.79	No	Yes	0	5	7
55	R:R:R77	R:R:Y302	16.46	No	No	0	8	9
56	R:R:H79	R:R:I126	2.65	No	Yes	0	9	7
57	R:R:H79	R:R:V156	6.92	No	No	0	9	5
58	R:R:H79	R:R:W161	6.35	No	No	0	9	9
59	R:R:D84	R:R:L80	5.43	Yes	No	0	9	9
60	R:R:I126	R:R:L80	5.71	Yes	No	0	7	9
61	R:R:A83	R:R:N119	3.13	No	No	0	8	8
62	R:R:D84	R:R:N119	5.39	Yes	No	0	9	8
63	R:R:C295	R:R:D84	4.67	No	Yes	0	9	9
64	R:R:D84	R:R:N298	4.04	Yes	No	0	9	9
65	R:R:F87	R:R:L91	3.65	Yes	Yes	2	7	8
66	R:R:F87	R:R:Y116	6.19	Yes	Yes	2	7	6
67	R:R:F87	R:R:N119	8.46	Yes	No	0	7	8
68	R:R:F292	R:R:F87	13.93	Yes	Yes	2	7	7
69	R:R:T90	R:R:V112	4.76	No	No	0	6	5
70	R:R:I115	R:R:T90	6.08	No	No	0	5	6
71	R:R:L91	R:R:W94	3.42	Yes	Yes	2	8	7
72	R:R:F104	R:R:F93	4.29	No	No	0	7	6
73	R:R:F93	R:R:L108	6.09	No	No	0	6	5
74	R:R:F93	R:R:V112	2.62	No	No	0	6	5
75	R:R:V112	R:R:W94	4.9	No	Yes	0	5	7
76	R:R:W94	R:R:Y116	4.82	Yes	Yes	2	7	6
77	R:R:F104	R:R:V96	2.62	No	No	0	7	5
78	R:R:D97	R:R:W102	6.7	No	Yes	0	5	9
79	R:R:A100	R:R:Y103	2.67	No	No	0	5	3
80	R:R:F104	R:R:W102	15.03	No	Yes	0	7	9
81	R:R:C109	R:R:W102	3.92	No	Yes	1	9	9
82	R:R:C186	R:R:W102	10.45	No	Yes	1	9	9
83	R:R:N106	R:R:N176	6.81	No	No	0	3	4
84	R:R:N106	R:R:V177	5.91	No	No	0	3	4
85	R:R:C109	R:R:H113	2.95	No	Yes	1	9	6
86	R:R:C109	R:R:C186	7.28	No	No	1	9	9
87	R:R:D171	R:R:H113	6.3	No	Yes	1	4	6
88	R:R:A175	R:R:H113	4.39	No	Yes	0	4	6
89	R:R:C186	R:R:H113	4.42	No	Yes	1	9	6
90	R:R:H113	R:R:R188	3.39	Yes	No	1	6	5
91	R:R:F172	R:R:V114	6.55	No	No	0	4	5
92	R:R:E288	R:R:Y116	4.49	No	Yes	0	5	6
93	R:R:F292	R:R:Y116	3.09	Yes	Yes	2	7	6
94	R:R:T117	R:R:T168	4.71	No	No	0	5	6
95	R:R:D171	R:R:T117	8.67	No	No	0	4	5
96	R:R:T168	R:R:V118	3.17	No	No	0	6	5
97	R:R:H203	R:R:L120	6.43	Yes	No	0	4	7
98	R:R:L167	R:R:Y121	11.72	No	No	3	5	7
99	R:R:Q202	R:R:Y121	6.76	No	No	3	3	7
100	R:R:H203	R:R:Y121	5.44	Yes	No	3	4	7
101	R:R:I126	R:R:S122	3.1	Yes	No	0	7	7
102	R:R:F248	R:R:S123	6.61	Yes	No	0	9	9
103	R:R:F248	R:R:V124	2.62	Yes	No	0	9	7
104	R:R:L125	R:R:V160	2.98	No	Yes	0	5	7
105	R:R:I126	R:R:I130	2.94	Yes	No	0	7	8
106	R:R:I126	R:R:V160	3.07	Yes	Yes	0	7	7
107	R:R:L127	R:R:L244	2.77	No	No	0	8	7
108	R:R:F248	R:R:L127	8.53	Yes	No	0	9	8
109	R:R:F129	R:R:L151	3.65	Yes	No	7	5	4
110	R:R:F129	R:R:V155	5.24	Yes	No	7	5	2
111	R:R:F129	R:R:V160	5.24	Yes	Yes	0	5	7
112	R:R:I215	R:R:S131	7.74	Yes	No	0	7	9
113	R:R:C218	R:R:S131	3.44	No	No	0	6	9
114	R:R:D133	R:R:R134	3.57	Yes	No	0	8	9
115	R:R:D133	R:R:R148	11.91	Yes	No	0	8	6
116	R:R:A137	R:R:R134	4.15	No	No	0	8	9
117	R:R:L136	R:R:Y135	3.52	No	Yes	0	5	8
118	R:R:V139	R:R:Y135	10.09	No	Yes	4	7	8
119	R:R:H140	R:R:Y135	8.71	No	Yes	4	6	8
120	R:R:C218	R:R:Y135	6.72	No	Yes	0	6	8
121	R:R:I221	R:R:Y135	4.84	No	Yes	0	4	8
122	R:R:A137	R:R:R148	5.53	No	No	0	8	6
123	R:R:I138	R:R:I222	4.42	No	Yes	4	8	8
124	R:R:I138	R:R:L238	4.28	No	No	4	8	5
125	R:R:H140	R:R:V139	11.07	No	No	4	6	7
126	R:R:K225	R:R:V139	3.04	No	No	0	4	7
127	R:R:N143	R:R:T142	7.31	No	No	0	5	5
128	R:R:P147	R:R:S144	7.13	No	No	0	4	5
129	R:R:R148	R:R:S144	2.64	No	No	0	6	5
130	R:R:P147	R:R:R146	7.21	No	No	0	4	5
131	R:R:K154	R:R:L150	4.23	No	No	0	3	4
132	R:R:L151	R:R:V155	8.94	No	No	7	4	2
133	R:R:A152	R:R:E153	3.02	No	No	0	3	7
134	R:R:V156	R:R:V160	4.81	No	Yes	0	5	7
135	R:R:W161	R:R:Y157	2.89	No	No	0	9	7
136	R:R:G159	R:R:V158	5.52	No	No	0	3	4
137	R:R:I162	R:R:P163	3.39	No	No	0	4	4
138	R:R:I162	R:R:L166	2.85	No	No	0	4	4
139	R:R:L165	R:R:T168	2.95	No	No	0	3	6
140	R:R:I169	R:R:L166	2.85	No	No	0	3	4
141	R:R:L167	R:R:Q202	3.99	No	No	3	5	3
142	R:R:I169	R:R:P170	3.39	No	No	0	3	8
143	R:R:F199	R:R:P170	5.78	No	No	0	5	8
144	R:R:D171	R:R:R188	11.91	No	No	1	4	5
145	R:R:F174	R:R:Y190	10.32	No	Yes	1	4	4
146	R:R:F174	R:R:W195	4.01	No	Yes	1	4	5
147	R:R:F189	R:R:S178	3.96	No	No	0	3	1
148	R:R:E179	R:R:Y184	8.98	No	No	0	2	5
149	R:R:D187	R:R:I185	2.8	No	No	0	3	3
150	R:R:D187	R:R:F189	3.58	No	No	0	3	3
151	R:R:R188	R:R:Y190	12.35	No	Yes	1	5	4
152	R:R:W195	R:R:Y190	3.86	Yes	Yes	1	5	4
153	R:R:V196	R:R:Y190	6.31	No	Yes	0	4	4
154	R:R:F199	R:R:Y190	9.28	No	Yes	0	5	4
155	R:R:N192	R:R:P191	9.77	No	No	1	1	5
156	R:R:P191	R:R:W195	6.76	No	Yes	1	5	5
157	R:R:N192	R:R:W195	6.78	No	Yes	1	1	5
158	R:R:Q200	R:R:V196	2.87	No	No	0	5	4
159	R:R:L266	R:R:V196	2.98	No	No	0	3	4
160	R:R:L266	R:R:V197	4.47	No	No	0	3	3
161	R:R:L267	R:R:V197	7.45	No	No	0	1	3
162	R:R:Q200	R:R:S263	4.33	No	No	0	5	5
163	R:R:F201	R:R:S263	6.61	No	No	0	4	5
164	R:R:Q202	R:R:V206	5.73	No	No	0	3	4
165	R:R:H203	R:R:Y255	4.36	Yes	Yes	3	4	7
166	R:R:H203	R:R:Y256	5.44	Yes	Yes	3	4	8
167	R:R:H203	R:R:I259	2.65	Yes	Yes	3	4	5
168	R:R:I204	R:R:I259	5.89	No	Yes	0	5	5
169	R:R:I204	R:R:S260	4.64	No	No	0	5	5
170	R:R:G207	R:R:Y256	2.9	No	Yes	0	5	8
171	R:R:L208	R:R:Y256	11.72	No	Yes	0	8	8
172	R:R:L210	R:R:P211	3.28	No	No	0	6	9
173	R:R:I215	R:R:I245	2.94	Yes	No	8	7	7
174	R:R:T241	R:R:Y219	6.24	Yes	No	0	7	8
175	R:R:I245	R:R:Y219	3.63	No	No	0	7	8
176	R:R:I222	R:R:L226	2.85	Yes	No	0	8	8
177	R:R:I222	R:R:L238	2.85	Yes	No	4	8	5
178	R:R:K225	R:R:S224	4.59	No	No	0	4	4
179	R:R:K234	R:R:L226	5.64	No	No	0	7	8
180	R:R:H228	R:R:S229	5.58	No	No	0	5	5
181	R:R:G231	R:R:R235	6	No	No	0	4	5
182	R:R:I243	R:R:K239	2.91	No	No	0	5	6
183	R:R:T240	R:R:T241	3.14	No	Yes	0	7	7
184	R:R:L246	R:R:V242	4.47	No	No	0	5	4
185	R:R:I243	R:R:L301	2.85	No	No	0	5	7
186	R:R:F248	R:R:W252	8.02	Yes	Yes	3	9	9
187	R:R:F248	R:R:H294	13.58	Yes	Yes	3	9	9
188	R:R:C251	R:R:H294	4.42	No	Yes	0	8	9
189	R:R:W252	R:R:Y255	6.75	Yes	Yes	3	9	7
190	R:R:W252	R:R:Y256	5.79	Yes	Yes	3	9	8
191	R:R:A291	R:R:W252	10.37	No	Yes	0	8	9
192	R:R:H294	R:R:W252	13.75	Yes	Yes	3	9	9
193	R:R:P254	R:R:T287	5.25	No	No	0	9	6
194	R:R:Y255	R:R:Y256	3.97	Yes	Yes	3	7	8
195	R:R:I259	R:R:Y255	9.67	Yes	Yes	3	5	7
196	R:R:T287	R:R:Y255	4.99	No	Yes	0	6	7
197	R:R:E288	R:R:Y255	5.61	No	Yes	0	5	7
198	R:R:I259	R:R:Y256	3.63	Yes	Yes	3	5	8
199	R:R:G258	R:R:I257	3.53	No	No	0	4	6
200	R:R:I257	R:R:I261	2.94	No	No	0	6	5
201	R:R:I259	R:R:I284	4.42	Yes	No	0	5	4
202	R:R:I261	R:R:I265	2.94	No	Yes	0	5	3
203	R:R:I261	R:R:V280	3.07	No	No	0	5	5
204	R:R:D262	R:R:V280	4.38	No	No	9	5	5
205	R:R:D262	R:R:H281	7.56	No	No	9	5	4
206	R:R:D262	R:R:I284	2.8	No	No	0	5	4
207	R:R:F264	R:R:I269	5.02	No	No	5	4	1
208	R:R:F264	R:R:I270	3.77	No	Yes	5	4	5
209	R:R:I265	R:R:I270	2.94	Yes	Yes	5	3	5
210	R:R:E277	R:R:I265	4.1	No	Yes	0	2	3
211	R:R:I269	R:R:I270	2.94	No	Yes	5	1	5
212	R:R:I270	R:R:Q272	4.12	Yes	No	0	5	2
213	R:R:K282	R:R:N278	2.8	No	No	0	2	3
214	R:R:H281	R:R:V280	2.77	No	No	9	4	5
215	R:R:T287	R:R:W283	3.64	No	No	0	6	6
216	R:R:E288	R:R:I284	2.73	No	No	0	5	4
217	R:R:C295	R:R:H294	4.42	No	Yes	0	9	9
218	R:R:N298	R:R:P299	11.4	No	No	0	9	9
219	R:R:R134	R:R:T241	2.59	No	Yes	0	9	7
220	R:R:F293	R:R:I47	2.51	No	No	0	5	4
221	R:R:F174	R:R:I173	2.51	No	No	0	4	3
222	R:R:F249	R:R:I215	2.51	No	Yes	8	4	7
223	R:R:F249	R:R:I245	2.51	No	No	8	4	7
224	R:R:F276	R:R:I265	2.51	No	Yes	5	1	3
225	R:R:F276	R:R:I270	2.51	No	Yes	5	1	5
226	R:R:F304	R:R:I300	2.51	No	No	0	6	6
227	R:R:L301	R:R:R77	2.43	No	No	0	7	8
228	R:R:I222	R:R:Y135	2.42	Yes	Yes	4	8	8
229	R:R:I222	R:R:Y219	2.42	Yes	No	0	8	8
230	R:R:N101	R:R:Y103	2.33	No	No	0	4	3
231	R:R:N101	R:R:Y184	2.33	No	No	0	4	5
232	R:R:D182	R:R:Y184	2.3	No	No	0	6	5
233	R:R:G159	R:R:P163	2.03	No	No	0	3	4
234	R:R:C296	R:R:G52	1.96	No	No	0	7	8
235	R:R:A128	R:R:P211	1.87	No	No	0	7	9
236	R:R:G52	R:R:V88	1.84	No	No	0	8	6
237	R:R:G55	R:R:V54	1.84	No	No	0	8	4
238	R:R:P42	R:R:V99	1.77	No	No	0	5	4
239	R:R:P211	R:R:V124	1.77	No	No	0	9	7
240	R:R:G212	R:R:I215	1.76	No	Yes	0	6	7
241	R:R:G64	R:R:M63	1.75	No	Yes	0	2	6
242	R:R:G231	R:R:K230	1.74	No	No	0	4	5
243	R:R:G64	R:R:L78	1.71	No	No	0	2	5
244	R:R:A100	R:R:V99	1.7	No	No	0	5	4
245	R:R:L41	R:R:P42	1.64	Yes	No	0	6	5
246	R:R:L253	R:R:P254	1.64	No	No	0	5	9
247	R:R:A175	R:R:K110	1.61	No	No	0	4	7
248	R:R:V114	R:R:V118	1.6	No	No	0	5	5
249	R:R:C218	R:R:L132	1.59	No	No	0	6	6
250	R:R:G231	R:R:H232	1.59	No	No	0	4	4
251	R:R:T241	R:R:V242	1.59	Yes	No	0	7	4
252	R:R:C251	R:R:L297	1.59	No	No	0	8	6
253	R:R:I213	R:R:S217	1.55	No	No	0	3	3
254	R:R:A180	R:R:D181	1.54	No	No	0	1	2
255	R:R:C28	R:R:E31	1.52	No	No	0	9	5
256	R:R:C28	R:R:E277	1.52	No	No	0	9	2
257	R:R:I47	R:R:T43	1.52	No	No	0	4	4
258	R:R:I300	R:R:T51	1.52	No	No	0	6	5
259	R:R:A237	R:R:Q233	1.52	No	No	0	7	5
260	R:R:L86	R:R:V82	1.49	No	No	0	7	5
261	R:R:L194	R:R:V198	1.49	No	No	0	2	3
262	R:R:I53	R:R:I89	1.47	No	No	0	5	4
263	R:R:I209	R:R:I213	1.47	No	No	0	4	3
264	R:R:I209	R:R:M205	1.46	No	No	0	4	4
265	R:R:E179	R:R:S178	1.44	No	No	0	2	1
266	R:R:I286	R:R:L290	1.43	No	No	0	6	7
267	R:R:I286	R:R:N37	1.42	No	Yes	0	6	3
268	R:R:K110	R:R:N106	1.4	No	No	0	7	3
269	R:R:A111	R:R:F107	1.39	No	No	0	4	1
270	R:R:L58	R:R:L61	1.38	No	No	0	5	4
271	R:R:L41	R:R:N33	1.37	Yes	No	2	6	6
272	R:R:L41	R:R:N37	1.37	Yes	Yes	2	6	3
273	R:R:D193	R:R:L266	1.36	No	No	0	1	3
274	R:R:E153	R:R:K154	1.35	No	No	0	7	3
275	R:R:R70	R:R:S71	1.32	No	No	0	6	7
276	R:R:E31	R:R:N278	1.31	No	No	0	5	3
277	R:R:H228	R:R:K234	1.31	No	No	0	5	7
278	R:R:E277	R:R:N278	1.31	No	No	0	2	3
279	R:R:I185	R:R:R183	1.25	No	No	0	3	3
280	R:R:L226	R:R:R235	1.21	No	No	0	8	5
281	R:R:L61	R:R:Y65	1.17	No	No	0	4	5
282	R:R:F29	R:R:R30	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N37	3.5725	4	2	3
2	R:R:L41	2.444	5	2	6
3	R:R:Y45	3.99333	6	2	7
4	R:R:I48	4.955	4	0	7
5	R:R:N56	4.41	4	0	9
6	R:R:M63	3.522	5	6	6
7	R:R:K68	4.2325	4	0	6
8	R:R:Y76	4.236	5	0	7
9	R:R:D84	4.984	5	0	9
10	R:R:F87	8.0575	4	2	7
11	R:R:L91	3.36	4	2	8
12	R:R:W94	4.0075	4	2	7
13	R:R:W102	9.025	4	1	9
14	R:R:H113	4.29	5	1	6
15	R:R:Y116	4.6475	4	2	6
16	R:R:I126	3.494	5	0	7
17	R:R:F129	4.565	4	7	5
18	R:R:D133	6	4	0	8
19	R:R:Y135	6.05	6	4	8
20	R:R:V160	4.025	4	0	7
21	R:R:Y190	8.424	5	1	4
22	R:R:W195	5.3525	4	1	5
23	R:R:H203	4.864	5	3	4
24	R:R:I215	3.7375	4	8	7
25	R:R:I222	2.992	5	4	8
26	R:R:T241	3.39	4	0	7
27	R:R:F248	7.872	5	3	9
28	R:R:W252	8.936	5	3	9
29	R:R:Y255	5.89167	6	3	7
30	R:R:Y256	5.575	6	3	8
31	R:R:I259	5.252	5	3	5
32	R:R:I265	3.1225	4	5	3
33	R:R:I270	3.256	5	5	5
34	R:R:F292	6.745	4	2	7
35	R:R:H294	9.0425	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I261	R:R:I265	15.2455	2.94	No	Yes	0	5	3
2	R:R:I261	R:R:V280	18.6395	3.07	No	No	0	5	5
3	R:R:D262	R:R:V280	19.6939	4.38	No	No	9	5	5
4	R:R:D262	R:R:I284	21.865	2.8	No	No	0	5	4
5	R:R:E288	R:R:I284	21.3891	2.73	No	No	0	5	4
6	R:R:E288	R:R:Y116	37.8574	4.49	No	Yes	0	5	6
7	R:R:W94	R:R:Y116	51.9496	4.82	Yes	Yes	2	7	6
8	R:R:W94	R:R:Y45	12.3677	2.89	Yes	Yes	2	7	7
9	R:R:L41	R:R:Y45	33.4566	4.69	Yes	Yes	2	6	7
10	R:R:F292	R:R:Y45	15.6958	6.19	Yes	Yes	2	7	7
11	R:R:F292	R:R:I48	12.6606	3.77	Yes	Yes	0	7	7
12	R:R:F293	R:R:I48	10.376	5.02	No	Yes	0	5	7
13	R:R:F87	R:R:Y116	38.2382	6.19	Yes	Yes	2	7	6
14	R:R:F87	R:R:L91	46.5493	3.65	Yes	Yes	2	7	8
15	R:R:L91	R:R:W94	36.3819	3.42	Yes	Yes	2	8	7
16	R:R:C296	R:R:I48	16.1462	8.18	No	Yes	0	7	7
17	R:R:C296	R:R:G52	10.376	1.96	No	No	0	7	8
18	R:R:F87	R:R:N119	100	8.46	Yes	No	0	7	8
19	R:R:D84	R:R:N119	98.6307	5.39	Yes	No	0	9	8
20	R:R:D84	R:R:N56	40.4899	5.39	Yes	Yes	0	9	9
21	R:R:N56	R:R:S81	33.9985	2.98	Yes	No	0	9	9
22	R:R:S81	R:R:V59	32.6548	4.85	No	No	0	9	8
23	R:R:V59	R:R:Y302	31.3038	5.05	No	No	0	8	9
24	R:R:M63	R:R:Y302	24.5561	5.99	Yes	No	0	6	9
25	R:R:K68	R:R:M63	10.4273	2.88	Yes	Yes	0	6	6
26	R:R:D84	R:R:L80	78.2668	5.43	Yes	No	0	9	9
27	R:R:I126	R:R:L80	77.1867	5.71	Yes	No	0	7	9
28	R:R:I126	R:R:I130	61.9339	2.94	Yes	No	0	7	8
29	R:R:I130	R:R:Y76	59.7408	4.84	No	Yes	0	8	7
30	R:R:D133	R:R:Y76	54.388	5.75	Yes	Yes	0	8	7
31	R:R:W252	R:R:Y255	15.0405	6.75	Yes	Yes	3	9	7
32	R:R:H294	R:R:W252	12.7192	13.75	Yes	Yes	3	9	9
33	R:R:C295	R:R:H294	15.0441	4.42	No	Yes	0	9	9
34	R:R:E288	R:R:Y255	18.6065	5.61	No	Yes	0	5	7
35	R:R:V112	R:R:W94	90.0597	4.9	No	Yes	0	5	7
36	R:R:F93	R:R:V112	87.6835	2.62	No	No	0	6	5
37	R:R:F104	R:R:F93	86.036	4.29	No	No	0	7	6
38	R:R:F104	R:R:W102	84.4763	15.03	No	Yes	0	7	9
39	R:R:A100	R:R:V99	18.028	1.7	No	No	0	5	4
40	R:R:P42	R:R:V99	19.6353	1.77	No	No	0	5	4
41	R:R:L41	R:R:P42	21.2353	1.64	Yes	No	0	6	5
42	R:R:A100	R:R:Y103	16.4134	2.67	No	No	0	5	3
43	R:R:C109	R:R:W102	41.332	3.92	No	Yes	1	9	9
44	R:R:C186	R:R:W102	41.4345	10.45	No	Yes	1	9	9
45	R:R:C109	R:R:H113	40.3324	2.95	No	Yes	1	9	6
46	R:R:A175	R:R:H113	11.9137	4.39	No	Yes	0	4	6
47	R:R:C186	R:R:H113	40.4313	4.42	No	Yes	1	9	6
48	R:R:D171	R:R:H113	16.04	6.3	No	Yes	1	4	6
49	R:R:H113	R:R:R188	51.7519	3.39	Yes	No	1	6	5
50	R:R:D171	R:R:T117	14.2606	8.67	No	No	0	4	5
51	R:R:T117	R:R:T168	11.9137	4.71	No	No	0	5	6
52	R:R:D133	R:R:R134	44.4111	3.57	Yes	No	0	8	9
53	R:R:R134	R:R:T241	42.2583	2.59	No	Yes	0	9	7
54	R:R:T241	R:R:Y219	37.052	6.24	Yes	No	0	7	8
55	R:R:I222	R:R:Y135	13.4661	2.42	Yes	Yes	4	8	8
56	R:R:I222	R:R:Y219	28.8141	2.42	Yes	No	0	8	8
57	R:R:R188	R:R:Y190	50.1995	12.35	No	Yes	1	5	4
58	R:R:F199	R:R:Y190	18.7457	9.28	No	Yes	0	5	4
59	R:R:F199	R:R:P170	16.6258	5.78	No	No	0	5	8
60	R:R:I169	R:R:P170	14.2753	3.39	No	No	0	3	8
61	R:R:I169	R:R:L166	11.9137	2.85	No	No	0	3	4
62	R:R:N101	R:R:Y103	14.7915	2.33	No	No	0	4	3
63	R:R:N101	R:R:Y184	13.1622	2.33	No	No	0	4	5
64	R:R:V196	R:R:Y190	18.5406	6.31	No	Yes	0	4	4
65	R:R:I222	R:R:L226	11.749	2.85	Yes	No	0	8	8
66	R:R:I48	R:R:L91	14.678	2.85	Yes	Yes	0	7	8
67	R:R:L91	R:R:Y45	10.5737	3.52	Yes	Yes	2	8	7
68	R:R:F292	R:R:F87	16.3219	13.93	Yes	Yes	2	7	7
69	R:R:C295	R:R:D84	15.9777	4.67	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8YU7

PDB Summary
PDB	8YU7
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR4
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.01
Date	2025-03-05
D.O.I.	doi.org/10.1016/j.celrep.2025.115255

Net Summary
I_min	2.62
Number of Linked Nodes	256
Number of Links	282
Number of Hubs	35
Number of Links mediated by Hubs	128
Number of Communities	9
Number of Nodes involved in Communities	54
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	53110
Length Of Smallest Path	3
Average Path Length	15.8175
Length of Longest Path	34
Minimum Path Strength	1.275
Average Path Strength	5.10396
Maximum Path Strength	12.74
Minimum Path Correlation	0.7
Average Path Correlation	0.923301
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	41.9924
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7855
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • protein binding • binding • myosin binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • cellular process • apoptotic process • cell death • programmed cell death • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • cellular response to stimulus • chemotaxis • dendritic cell chemotaxis • response to stimulus • response to external stimulus • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • taxis • immune system process • response to chemical • mononuclear cell migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • neurogenesis • cellular developmental process • cell differentiation • regulation of response to external stimulus • regulation of chemotaxis • regulation of response to stimulus • regulation of locomotion • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • signaling • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • C-X-C chemokine receptor CXCR4 signaling pathway • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • regulation of multicellular organismal development • regulation of developmental process • positive regulation of biological process • vasculature development • regulation of vasculature development • circulatory system development • positive regulation of developmental process • positive regulation of vasculature development • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • positive regulation of response to stimulus • macrophage migration inhibitory factor signaling pathway • positive regulation of cellular process • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • positive regulation of nervous system development • cell development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell leading edge • intracellular anatomical structure • cytoplasm • anchoring junction • cell junction • intracellular organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein-containing complex • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • endomembrane system • late endosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8YU7_Chain_R E P C F R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	doi.org/10.1016/j.celrep.2025.115255
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	Gi1/β1/γ2	2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ2	3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	Gi1/β1/γ2	3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.1	2024-03-13	doi.org/10.1101/2024.02.09.579708
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	doi.org/10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	doi.org/10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	doi.org/10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	doi.org/10.1126/science.1261064
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	-	-	3.01	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	-	-	3.2	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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