psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F13	R:R:K25	3.72	No	No	0	0	4
2	L:L:V49	R:R:K25	4.55	No	No	0	0	4
3	L:L:R47	R:R:E26	6.98	No	No	0	0	2
4	L:L:C11	R:R:P27	3.77	No	No	0	0	5
5	L:L:Q48	R:R:P27	3.16	No	No	0	0	5
6	R:R:C274	R:R:C28	7.28	No	No	0	5	9
7	L:L:R8	R:R:R30	3.2	No	No	0	0	5
8	R:R:N278	R:R:N33	12.26	No	No	0	3	6
9	R:R:H281	R:R:N33	11.48	No	No	0	4	6
10	R:R:F36	R:R:F40	16.08	No	No	0	4	5
11	R:R:F36	R:R:K282	9.93	No	No	0	4	2
12	R:R:L41	R:R:N37	6.87	Yes	No	0	6	3
13	R:R:L41	R:R:Y45	15.24	Yes	Yes	0	6	7
14	R:R:I44	R:R:I48	2.94	No	No	0	5	7
15	R:R:E288	R:R:Y45	4.49	Yes	Yes	1	5	7
16	R:R:F292	R:R:Y45	7.22	Yes	Yes	1	7	7
17	R:R:F293	R:R:I48	7.54	No	No	0	5	7
18	R:R:F49	R:R:V88	3.93	No	Yes	0	6	6
19	R:R:F49	R:R:P92	8.67	No	No	0	6	9
20	R:R:C296	R:R:T51	3.38	No	No	0	7	5
21	R:R:I53	R:R:V88	3.07	No	Yes	0	5	6
22	R:R:G55	R:R:V54	3.68	No	No	0	8	4
23	R:R:N56	R:R:S81	2.98	Yes	No	0	9	9
24	R:R:D84	R:R:N56	6.73	Yes	Yes	0	9	9
25	R:R:L85	R:R:N56	5.49	No	Yes	0	7	9
26	R:R:N56	R:R:P299	4.89	Yes	No	0	9	9
27	R:R:S81	R:R:V59	4.85	No	No	0	9	8
28	R:R:F309	R:R:V62	9.18	Yes	No	0	8	7
29	R:R:A313	R:R:V62	3.39	No	No	0	5	7
30	R:R:D74	R:R:M63	4.16	Yes	No	2	8	6
31	R:R:M63	R:R:R77	3.72	No	Yes	2	6	8
32	R:R:K68	R:R:Q66	5.42	No	Yes	0	6	4
33	R:R:Q66	R:R:R70	3.5	Yes	No	2	4	6
34	R:R:D74	R:R:Q66	5.22	Yes	Yes	2	8	4
35	R:R:Q66	R:R:S312	7.22	Yes	No	0	4	6
36	R:R:D74	R:R:R70	4.76	Yes	No	2	8	6
37	R:R:R70	W:W:?1	12.11	No	Yes	0	6	0
38	R:R:D74	R:R:S71	2.94	Yes	No	0	8	7
39	R:R:A152	R:R:M72	3.22	No	No	0	3	6
40	R:R:R77	R:R:T73	3.88	Yes	No	0	8	7
41	R:R:D74	R:R:R77	3.57	Yes	Yes	2	8	8
42	R:R:E153	R:R:K75	10.8	No	No	0	7	6
43	R:R:I130	R:R:Y76	6.04	Yes	Yes	0	8	7
44	R:R:D133	R:R:Y76	9.2	No	Yes	0	8	7
45	R:R:A152	R:R:Y76	5.34	No	Yes	0	3	7
46	R:R:V156	R:R:Y76	3.79	No	Yes	0	5	7
47	R:R:F309	R:R:R77	5.34	Yes	Yes	0	8	8
48	R:R:L78	W:W:?1	8.28	No	Yes	0	5	0
49	R:R:H79	R:R:I126	5.3	No	Yes	0	9	7
50	R:R:H79	W:W:?1	7.69	No	Yes	0	9	0
51	R:R:D84	R:R:L80	4.07	Yes	No	1	9	9
52	R:R:I126	R:R:L80	4.28	Yes	No	0	7	9
53	R:R:L80	R:R:N298	9.61	No	No	1	9	9
54	R:R:V82	W:W:?1	7.43	No	Yes	0	5	0
55	R:R:D84	R:R:S123	2.94	Yes	No	0	9	9
56	R:R:C295	R:R:D84	4.67	Yes	Yes	1	9	9
57	R:R:D84	R:R:N298	8.08	Yes	No	1	9	9
58	R:R:F87	R:R:Y116	4.13	Yes	Yes	1	7	6
59	R:R:F87	R:R:S119	5.28	Yes	No	0	7	8
60	R:R:F292	R:R:F87	8.57	Yes	Yes	1	7	7
61	R:R:F87	R:R:H294	10.18	Yes	Yes	1	7	9
62	R:R:C295	R:R:F87	5.59	Yes	Yes	1	9	7
63	R:R:C295	R:R:V88	3.42	Yes	Yes	0	9	6
64	R:R:T90	R:R:W94	4.85	No	Yes	0	6	7
65	R:R:I115	R:R:T90	3.04	No	No	0	5	6
66	R:R:F104	R:R:F93	6.43	Yes	No	0	7	6
67	R:R:F93	R:R:V112	9.18	No	No	0	6	5
68	R:R:V112	R:R:W94	4.9	No	Yes	0	5	7
69	R:R:H113	R:R:W94	7.41	Yes	Yes	1	6	7
70	R:R:W94	R:R:Y116	2.89	Yes	Yes	1	7	6
71	L:L:K1	R:R:W94	3.48	Yes	Yes	1	0	7
72	L:L:P2	R:R:W94	10.81	Yes	Yes	1	0	7
73	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
74	R:R:D97	R:R:W102	10.05	No	Yes	0	5	9
75	R:R:D97	R:R:I185	4.2	No	No	0	5	3
76	L:L:K1	R:R:D97	4.15	Yes	No	0	0	5
77	R:R:A100	R:R:N101	3.13	No	No	0	5	4
78	R:R:N101	R:R:Y103	19.77	No	No	0	4	3
79	R:R:N101	R:R:R183	6.03	No	No	0	4	3
80	R:R:F104	R:R:W102	8.02	Yes	Yes	0	7	9
81	R:R:C109	R:R:W102	5.22	No	Yes	1	9	9
82	R:R:V177	R:R:W102	3.68	No	Yes	0	4	9
83	R:R:C186	R:R:W102	14.37	No	Yes	1	9	9
84	R:R:F104	R:R:L108	6.09	Yes	No	0	7	5
85	R:R:K110	R:R:N106	6.99	No	No	0	7	3
86	R:R:N106	R:R:N176	6.81	No	No	0	3	4
87	R:R:N106	R:R:V177	2.96	No	No	0	3	4
88	R:R:C109	R:R:H113	2.95	No	Yes	1	9	6
89	R:R:C109	R:R:C186	7.28	No	No	1	9	9
90	R:R:D171	R:R:H113	6.3	No	Yes	0	4	6
91	R:R:A175	R:R:H113	2.93	No	Yes	0	4	6
92	R:R:C186	R:R:H113	7.37	No	Yes	1	9	6
93	L:L:K1	R:R:H113	5.24	Yes	Yes	1	0	6
94	R:R:T168	R:R:V114	4.76	No	No	0	6	5
95	R:R:F172	R:R:V114	11.8	No	No	0	4	5
96	R:R:L120	R:R:Y116	3.52	No	Yes	0	7	6
97	R:R:F292	R:R:Y116	5.16	Yes	Yes	1	7	6
98	R:R:A164	R:R:V118	3.39	No	No	0	7	5
99	R:R:L167	R:R:Y121	4.69	No	Yes	5	5	7
100	R:R:Q202	R:R:Y121	5.64	No	Yes	5	3	7
101	R:R:H203	R:R:Y121	7.62	No	Yes	0	4	7
102	R:R:S122	R:R:V160	3.23	No	Yes	6	7	7
103	R:R:S122	R:R:W161	8.65	No	Yes	6	7	9
104	R:R:H294	R:R:S123	8.37	Yes	No	0	9	9
105	R:R:P211	R:R:V124	3.53	Yes	No	0	9	7
106	R:R:L125	R:R:V160	5.96	No	Yes	0	5	7
107	R:R:I126	R:R:I130	2.94	Yes	Yes	0	7	8
108	R:R:I126	R:R:V160	9.22	Yes	Yes	0	7	7
109	R:R:L127	R:R:Y302	7.03	No	No	0	8	9
110	R:R:F129	R:R:G159	3.01	Yes	No	0	5	3
111	R:R:I130	R:R:R134	6.26	Yes	No	4	8	9
112	R:R:I130	R:R:Y302	6.04	Yes	No	4	8	9
113	R:R:I215	R:R:S131	6.19	No	No	0	7	9
114	R:R:S131	R:R:Y219	3.82	No	Yes	0	9	8
115	R:R:D133	R:R:R148	11.91	No	No	0	8	6
116	R:R:R134	R:R:Y219	6.17	No	Yes	0	9	8
117	R:R:R134	R:R:Y302	6.17	No	No	4	9	9
118	R:R:L136	R:R:Y135	4.69	No	Yes	0	5	8
119	R:R:V139	R:R:Y135	7.57	No	Yes	7	7	8
120	R:R:H140	R:R:Y135	4.36	No	Yes	7	6	8
121	R:R:C218	R:R:Y135	5.38	Yes	Yes	0	6	8
122	R:R:I221	R:R:Y135	6.04	No	Yes	0	4	8
123	R:R:L136	R:R:S144	4.5	No	No	0	5	5
124	R:R:A137	R:R:R148	5.53	No	No	0	8	6
125	R:R:H140	R:R:V139	8.3	No	No	7	6	7
126	R:R:K225	R:R:V139	4.55	No	No	0	4	7
127	R:R:K154	R:R:L150	4.23	No	No	0	3	4
128	R:R:L150	R:R:V155	2.98	No	No	0	4	2
129	R:R:Y157	W:W:?1	14.03	No	Yes	0	7	0
130	R:R:V160	R:R:W161	3.68	Yes	Yes	6	7	9
131	R:R:W161	W:W:?1	9.09	Yes	Yes	0	9	0
132	R:R:I162	R:R:P163	3.39	No	No	0	4	4
133	R:R:L165	W:W:?1	4.14	No	Yes	0	3	0
134	R:R:L167	R:R:Q202	9.32	No	No	5	5	3
135	R:R:I169	R:R:P170	3.39	No	No	0	3	8
136	R:R:I169	R:R:I173	2.94	No	No	0	3	3
137	R:R:F174	R:R:P170	2.89	Yes	No	0	4	8
138	R:R:F199	R:R:P170	5.78	Yes	No	0	5	8
139	R:R:D171	R:R:R188	11.91	No	No	0	4	5
140	R:R:F174	R:R:I173	5.02	Yes	No	0	4	3
141	R:R:F174	R:R:R188	5.34	Yes	No	3	4	5
142	R:R:F174	R:R:Y190	6.19	Yes	Yes	3	4	4
143	R:R:F174	R:R:W195	3.01	Yes	Yes	3	4	5
144	R:R:F189	R:R:S178	6.61	No	No	8	3	1
145	L:L:N33	R:R:S178	5.96	No	No	8	0	1
146	R:R:E179	R:R:Y184	3.37	No	No	0	2	5
147	R:R:D182	R:R:R183	3.57	No	No	0	6	3
148	L:L:K1	R:R:D187	11.06	Yes	No	0	0	3
149	L:L:S6	R:R:D187	5.89	No	No	0	0	3
150	L:L:Y7	R:R:D187	3.45	No	No	0	0	3
151	R:R:R188	R:R:Y190	16.46	No	Yes	3	5	4
152	L:L:N33	R:R:F189	26.58	No	No	8	0	3
153	R:R:W195	R:R:Y190	4.82	Yes	Yes	3	5	4
154	R:R:V196	R:R:Y190	7.57	No	Yes	0	4	4
155	R:R:F199	R:R:Y190	6.19	Yes	Yes	3	5	4
156	R:R:P191	R:R:W195	5.4	No	Yes	0	5	5
157	R:R:L194	R:R:N192	6.87	No	No	0	2	1
158	R:R:N192	R:R:W195	4.52	No	Yes	0	1	5
159	L:L:R12	R:R:D193	19.06	No	No	0	0	1
160	R:R:L194	R:R:V197	2.98	No	No	0	2	3
161	R:R:F199	R:R:W195	7.02	Yes	Yes	3	5	5
162	R:R:L266	R:R:V196	2.98	No	No	0	3	4
163	R:R:L266	R:R:V197	2.98	No	No	0	3	3
164	R:R:F199	R:R:V198	3.93	Yes	No	0	5	3
165	R:R:I259	R:R:Q200	5.49	No	No	0	5	5
166	R:R:D262	R:R:Q200	6.53	No	No	0	5	5
167	R:R:Q200	R:R:S263	5.78	No	No	0	5	5
168	R:R:F201	R:R:S263	6.61	No	No	0	4	5
169	R:R:Q202	R:R:V206	5.73	No	No	0	3	4
170	R:R:H203	R:R:Y256	7.62	No	Yes	0	4	8
171	R:R:I204	R:R:I259	5.89	No	No	0	5	5
172	R:R:I204	R:R:S260	3.1	No	No	0	5	5
173	R:R:I209	R:R:M205	5.83	No	No	0	4	4
174	R:R:G207	R:R:Y256	4.35	No	Yes	0	5	8
175	R:R:L208	R:R:Y256	10.55	No	Yes	0	8	8
176	R:R:L210	R:R:P211	3.28	No	Yes	0	6	9
177	R:R:C220	R:R:L216	3.17	No	No	0	3	4
178	R:R:F249	R:R:L216	6.09	No	No	0	4	4
179	R:R:C218	R:R:S217	3.44	Yes	No	0	6	3
180	R:R:T241	R:R:Y219	4.99	Yes	Yes	0	7	8
181	R:R:L244	R:R:Y219	3.52	No	Yes	0	7	8
182	R:R:I245	R:R:Y219	8.46	No	Yes	0	7	8
183	R:R:I223	R:R:T241	6.08	No	Yes	0	4	7
184	R:R:K234	R:R:L226	4.23	No	Yes	0	7	8
185	R:R:H228	R:R:S227	4.18	No	No	0	5	4
186	R:R:H228	R:R:S229	4.18	No	No	0	5	5
187	R:R:K234	R:R:S229	9.18	No	No	0	7	5
188	R:R:G231	R:R:R235	3	No	No	0	4	5
189	R:R:L244	R:R:T240	2.95	No	No	0	7	7
190	R:R:L244	R:R:L301	5.54	No	Yes	0	7	7
191	R:R:F248	R:R:F249	5.36	No	No	0	9	4
192	R:R:F248	R:R:W252	7.02	No	Yes	0	9	9
193	R:R:C251	R:R:W252	3.92	No	Yes	0	8	9
194	R:R:W252	R:R:Y256	5.79	Yes	Yes	0	9	8
195	R:R:H294	R:R:W252	12.7	Yes	Yes	0	9	9
196	R:R:L253	R:R:P254	4.93	No	No	0	5	9
197	R:R:I257	R:R:L253	4.28	No	No	0	6	5
198	R:R:P254	R:R:T287	5.25	No	No	0	9	6
199	R:R:Y255	R:R:Y256	4.96	Yes	Yes	0	7	8
200	R:R:I259	R:R:Y255	12.09	No	Yes	0	5	7
201	R:R:E288	R:R:Y255	4.49	Yes	Yes	0	5	7
202	R:R:I261	R:R:V280	3.07	No	No	0	5	5
203	R:R:F276	R:R:I265	5.02	No	No	0	1	3
204	L:L:R8	R:R:L266	7.29	No	No	0	0	3
205	R:R:I269	R:R:L267	7.14	No	No	0	1	1
206	L:L:F13	R:R:E268	18.66	No	No	0	0	2
207	R:R:E275	R:R:G273	4.91	No	No	0	3	5
208	R:R:C274	R:R:E277	7.6	No	No	0	5	2
209	R:R:F276	R:R:V280	3.93	No	No	0	1	5
210	R:R:I284	R:R:V280	3.07	Yes	No	0	4	5
211	R:R:I286	R:R:K282	7.27	No	No	0	6	2
212	R:R:T287	R:R:W283	6.06	No	No	0	6	6
213	L:L:V3	R:R:I284	3.07	No	Yes	0	0	4
214	L:L:S4	R:R:S285	4.89	No	No	0	0	5
215	R:R:E288	R:R:F292	8.16	Yes	Yes	1	5	7
216	L:L:S4	R:R:E288	10.06	No	Yes	0	0	5
217	L:L:P2	R:R:F292	2.89	Yes	Yes	1	0	7
218	R:R:C296	R:R:F293	4.19	No	No	0	7	5
219	R:R:C295	R:R:H294	2.95	Yes	Yes	1	9	9
220	R:R:A303	R:R:F309	8.32	No	Yes	0	7	8
221	R:R:F304	R:R:F309	6.43	No	Yes	0	6	8
222	L:L:K1	L:L:P2	3.35	Yes	Yes	1	0	0
223	L:L:K1	L:L:L5	4.23	Yes	Yes	1	0	0
224	L:L:L5	L:L:P2	8.21	Yes	Yes	1	0	0
225	L:L:L5	L:L:S4	3	Yes	No	0	0	0
226	L:L:C9	L:L:Y7	4.03	No	No	0	0	0
227	L:L:T31	L:L:Y7	3.75	Yes	No	0	0	0
228	L:L:C34	L:L:C9	7.28	No	No	0	0	0
229	L:L:L29	L:L:P10	3.28	No	No	0	0	0
230	L:L:C11	L:L:Q37	3.05	No	Yes	0	0	0
231	L:L:C11	L:L:C50	7.28	No	No	0	0	0
232	L:L:F13	L:L:R12	11.76	No	No	0	0	0
233	L:L:D52	L:L:F14	23.88	No	No	0	0	0
234	L:L:E15	L:L:V18	11.41	No	No	10	0	0
235	L:L:E15	L:L:I51	10.93	No	Yes	10	0	0
236	L:L:I51	L:L:V18	3.07	Yes	No	10	0	0
237	L:L:R20	L:L:V23	3.92	No	No	11	0	0
238	L:L:R20	L:L:W57	28.99	No	No	11	0	0
239	L:L:L42	L:L:N22	8.24	No	No	0	0	0
240	L:L:K43	L:L:N22	4.2	No	No	0	0	0
241	L:L:N22	L:L:N44	16.35	No	No	0	0	0
242	L:L:L26	L:L:V23	2.98	No	No	0	0	0
243	L:L:V23	L:L:W57	6.13	No	No	11	0	0
244	L:L:H25	L:L:K24	17.03	No	No	0	0	0
245	L:L:K24	L:L:K43	2.87	No	No	0	0	0
246	L:L:K24	L:L:N46	8.39	No	No	0	0	0
247	L:L:H25	L:L:R41	12.41	No	No	0	0	0
248	L:L:L26	L:L:Y61	7.03	No	No	0	0	0
249	L:L:K27	L:L:V39	3.04	No	No	0	0	0
250	L:L:I28	L:L:I38	14.72	No	No	0	0	0
251	L:L:L29	L:L:T31	5.9	No	Yes	9	0	0
252	L:L:L29	L:L:Q37	11.98	No	Yes	9	0	0
253	L:L:P32	L:L:T31	3.5	No	Yes	0	0	0
254	L:L:Q37	L:L:T31	12.76	Yes	Yes	9	0	0
255	L:L:N33	L:L:P32	3.26	No	No	0	0	0
256	L:L:Q48	L:L:V39	8.6	No	No	0	0	0
257	L:L:Q48	L:L:R41	15.19	No	No	0	0	0
258	L:L:L42	L:L:V49	4.47	No	No	0	0	0
259	L:L:N45	L:L:R47	12.05	No	No	0	0	0
260	L:L:I51	L:L:V49	3.07	Yes	No	0	0	0
261	L:L:I51	L:L:I58	4.42	Yes	Yes	0	0	0
262	L:L:D52	L:L:P53	11.27	No	No	0	0	0
263	L:L:D52	L:L:K54	9.68	No	No	0	0	0
264	L:L:K54	L:L:Q59	4.07	No	No	0	0	0
265	L:L:I58	L:L:L55	5.71	Yes	No	0	0	0
266	L:L:K56	L:L:Q59	6.78	No	No	0	0	0
267	L:L:E60	L:L:K56	12.15	No	No	0	0	0
268	L:L:I58	L:L:W57	5.87	Yes	No	0	0	0
269	L:L:E60	L:L:K64	6.75	No	No	0	0	0
270	R:R:I48	R:R:L91	2.85	No	No	0	7	8
271	R:R:I60	R:R:L61	2.85	No	No	0	7	4
272	L:L:I58	L:L:L62	2.85	Yes	No	0	0	0
273	R:R:D262	R:R:I284	2.8	No	Yes	0	5	4
274	R:R:H281	R:R:S285	2.79	No	No	0	4	5
275	R:R:A289	R:R:F40	2.77	No	No	0	4	5
276	R:R:L132	R:R:L151	2.77	No	No	0	6	4
277	R:R:H315	R:R:T311	2.74	No	No	0	4	4
278	R:R:E277	R:R:I265	2.73	No	No	0	2	3
279	R:R:K149	R:R:Q145	2.71	No	No	0	6	5
280	R:R:E153	R:R:K149	2.7	No	No	0	7	6
281	R:R:E153	R:R:K154	2.7	No	No	0	7	3
282	R:R:L317	R:R:Q314	2.66	No	No	0	5	5
283	R:R:F264	R:R:S260	2.64	No	No	0	4	5
284	R:R:H79	R:R:K75	2.62	No	No	0	9	6
285	R:R:F129	R:R:V155	2.62	Yes	No	0	5	2
286	R:R:F129	R:R:V156	2.62	Yes	No	0	5	5
287	R:R:F129	R:R:V160	2.62	Yes	Yes	0	5	7
288	R:R:F40	R:R:I44	2.51	No	No	0	5	5
289	R:R:F264	R:R:I269	2.51	No	No	0	4	1
290	R:R:F304	R:R:I300	2.51	No	No	0	6	6
291	R:R:T117	R:R:Y121	2.5	No	Yes	0	5	7
292	R:R:V118	R:R:W161	2.45	No	Yes	0	5	9
293	R:R:V124	R:R:W252	2.45	No	Yes	0	7	9
294	R:R:F107	R:R:L108	2.44	No	No	0	1	5
295	R:R:L91	R:R:Y45	2.34	No	Yes	0	8	7
296	R:R:Q145	R:R:R146	2.34	No	No	0	5	5
297	R:R:F276	R:R:Q272	2.34	No	No	0	1	2
298	R:R:F104	R:R:Y103	2.06	Yes	No	0	7	3
299	R:R:G212	R:R:P211	2.03	No	Yes	0	6	9
300	R:R:A95	R:R:P42	1.87	No	No	0	7	5
301	R:R:A128	R:R:P211	1.87	No	Yes	0	7	9
302	R:R:G52	R:R:V88	1.84	No	Yes	0	8	6
303	R:R:P147	R:R:S144	1.78	No	No	0	4	5
304	R:R:G57	R:R:I60	1.76	No	No	0	3	7
305	R:R:G258	R:R:I261	1.76	No	No	0	4	5
306	R:R:G258	R:R:I284	1.76	No	Yes	0	4	4
307	R:R:G273	R:R:M24	1.75	No	No	0	5	2
308	R:R:G64	R:R:M63	1.75	No	No	0	2	6
309	R:R:A83	R:R:S122	1.71	No	No	0	8	7
310	R:R:C218	R:R:V214	1.71	Yes	No	0	6	6
311	R:R:A100	R:R:V99	1.7	No	No	0	5	4
312	L:L:I58	L:L:P53	1.69	Yes	No	0	0	0
313	R:R:L41	R:R:P42	1.64	Yes	No	0	6	5
314	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
315	R:R:S131	R:R:V214	1.62	No	No	0	9	6
316	R:R:C218	R:R:L132	1.59	Yes	No	0	6	6
317	R:R:T241	R:R:V242	1.59	Yes	No	0	7	4
318	R:R:C251	R:R:L297	1.59	No	No	0	8	6
319	R:R:A98	R:R:L41	1.58	No	Yes	0	5	6
320	L:L:L5	R:R:A98	1.58	Yes	No	0	0	5
321	R:R:A237	R:R:L226	1.58	No	Yes	0	7	8
322	R:R:A247	R:R:L301	1.58	No	Yes	0	6	7
323	L:L:A40	L:L:L26	1.58	No	No	0	0	0
324	R:R:E26	R:R:P27	1.57	No	No	0	2	5
325	R:R:T117	R:R:T168	1.57	No	No	0	5	6
326	R:R:I47	R:R:S46	1.55	No	No	0	4	5
327	R:R:I53	R:R:V54	1.54	No	No	0	5	4
328	R:R:A180	R:R:D181	1.54	No	No	0	1	2
329	R:R:I47	R:R:T43	1.52	No	No	0	4	4
330	R:R:I47	R:R:T51	1.52	No	No	0	4	5
331	R:R:I89	R:R:T90	1.52	No	No	0	4	6
332	R:R:I222	R:R:T241	1.52	No	Yes	0	8	7
333	R:R:A34	R:R:E31	1.51	No	No	0	1	5
334	R:R:L86	R:R:S119	1.5	No	No	0	7	8
335	R:R:L238	R:R:S227	1.5	No	No	0	5	4
336	L:L:L55	L:L:S16	1.5	No	No	0	0	0
337	R:R:L246	R:R:V242	1.49	No	No	0	5	4
338	R:R:I257	R:R:I261	1.47	No	No	0	6	5
339	R:R:I269	R:R:I270	1.47	No	No	0	1	5
340	R:R:L317	R:R:T318	1.47	No	No	0	5	4
341	R:R:N143	R:R:T142	1.46	No	No	0	5	5
342	L:L:P10	R:R:F29	1.44	No	No	0	0	4
343	R:R:I60	R:R:L78	1.43	No	No	0	7	5
344	R:R:I138	R:R:L226	1.43	No	Yes	0	8	8
345	R:R:I222	R:R:L226	1.43	No	Yes	0	8	8
346	R:R:I223	R:R:L238	1.43	No	No	0	4	5
347	R:R:I243	R:R:L301	1.43	No	Yes	0	5	7
348	L:L:I28	L:L:L36	1.43	No	No	0	0	0
349	R:R:G105	R:R:W102	1.41	No	Yes	0	8	9
350	R:R:L210	R:R:M205	1.41	No	No	0	6	4
351	R:R:L301	R:R:L305	1.38	Yes	No	0	7	6
352	R:R:A316	R:R:Y65	1.33	No	No	0	5	5
353	R:R:D181	R:R:D182	1.33	No	No	0	2	6
354	R:R:A291	R:R:Y255	1.33	No	Yes	0	8	7
355	L:L:L36	L:L:Q37	1.33	No	Yes	0	0	0
356	R:R:E32	R:R:N278	1.31	No	No	0	4	3
357	R:R:E31	R:R:E32	1.27	No	No	0	5	4
358	R:R:V177	R:R:Y184	1.26	No	No	0	4	5
359	R:R:H232	R:R:Q233	1.24	No	No	0	4	5
360	L:L:E15	L:L:H17	1.23	No	No	0	0	0
361	R:R:F49	R:R:L50	1.22	No	No	0	6	5
362	R:R:F304	R:R:L58	1.22	No	No	0	6	5
363	R:R:F293	R:R:L290	1.22	No	No	0	5	7
364	R:R:N143	R:R:R146	1.21	No	No	0	5	5
365	R:R:H232	R:R:R235	1.13	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L41	6.3325	4	0	6
2	R:R:Y45	7.3225	4	1	7
3	R:R:N56	5.0225	4	0	9
4	R:R:Q66	5.34	4	2	4
5	R:R:D74	4.13	5	2	8
6	R:R:Y76	6.0925	4	0	7
7	R:R:R77	4.1275	4	2	8
8	R:R:D84	5.298	5	1	9
9	R:R:F87	6.75	5	1	7
10	R:R:V88	3.065	4	0	6
11	R:R:W94	5.72333	6	1	7
12	R:R:W102	7.125	6	1	9
13	R:R:F104	5.83	5	0	7
14	R:R:H113	5.36667	6	1	6
15	R:R:Y116	3.925	4	1	6
16	R:R:Y121	5.1125	4	5	7
17	R:R:I126	5.435	4	0	7
18	R:R:F129	2.7175	4	0	5
19	R:R:I130	5.32	4	4	8
20	R:R:Y135	5.608	5	7	8
21	R:R:V160	4.942	5	6	7
22	R:R:W161	5.9675	4	6	9
23	R:R:F174	4.49	5	3	4
24	R:R:Y190	8.246	5	3	4
25	R:R:W195	4.954	5	3	5
26	R:R:F199	5.73	4	3	5
27	R:R:P211	2.6775	4	0	9
28	R:R:C218	3.03	4	0	6
29	R:R:Y219	5.392	5	0	8
30	R:R:L226	2.1675	4	0	8
31	R:R:T241	3.545	4	0	7
32	R:R:W252	6.376	5	0	9
33	R:R:Y255	5.7175	4	0	7
34	R:R:Y256	6.654	5	0	8
35	R:R:I284	2.675	4	0	4
36	R:R:E288	6.8	4	1	5
37	R:R:F292	6.4	5	1	7
38	R:R:H294	8.55	4	1	9
39	R:R:C295	4.1575	4	1	9
40	R:R:L301	2.4825	4	0	7
41	R:R:F309	7.3175	4	0	8
42	L:L:K1	5.25167	6	1	0
43	L:L:P2	6.315	4	1	0
44	L:L:L5	4.255	4	1	0
45	L:L:T31	6.4775	4	9	0
46	L:L:Q37	7.28	4	9	0
47	L:L:I51	5.3725	4	10	0
48	L:L:I58	4.108	5	0	0
49	W:W:?1	8.96714	7	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L42	L:L:V49	33.2647	4.47	No	No	0	0	0
2	L:L:L42	L:L:N22	34.3849	8.24	No	No	0	0	0
3	L:L:K43	L:L:N22	36.6105	4.2	No	No	0	0	0
4	L:L:K24	L:L:K43	37.716	2.87	No	No	0	0	0
5	L:L:H25	L:L:K24	39.9122	17.03	No	No	0	0	0
6	L:L:H25	L:L:R41	41.003	12.41	No	No	0	0	0
7	L:L:Q48	L:L:R41	42.0889	15.19	No	No	0	0	0
8	L:L:Q48	R:R:P27	45.3171	3.16	No	No	0	0	5
9	L:L:C11	R:R:P27	49.5527	3.77	No	No	0	0	5
10	L:L:C11	L:L:Q37	51.6386	3.05	No	Yes	0	0	0
11	L:L:Q37	L:L:T31	55.4085	12.76	Yes	Yes	9	0	0
12	L:L:T31	L:L:Y7	63.7302	3.75	Yes	No	0	0	0
13	L:L:Y7	R:R:D187	66.6495	3.45	No	No	0	0	3
14	L:L:K1	R:R:D187	68.5712	11.06	Yes	No	0	0	3
15	L:L:K1	L:L:P2	42.1428	3.35	Yes	Yes	1	0	0
16	L:L:P2	R:R:F292	50.6189	2.89	Yes	Yes	1	0	7
17	R:R:E288	R:R:F292	38.9857	8.16	Yes	Yes	1	5	7
18	R:R:E288	R:R:Y255	54.6094	4.49	Yes	Yes	0	5	7
19	R:R:I259	R:R:Y255	62.3845	12.09	No	Yes	0	5	7
20	R:R:I259	R:R:Q200	50.7513	5.49	No	No	0	5	5
21	R:R:D262	R:R:Q200	45.6921	6.53	No	No	0	5	5
22	R:R:D262	R:R:I284	43.9959	2.8	No	Yes	0	5	4
23	R:R:I284	R:R:V280	28.2594	3.07	Yes	No	0	4	5
24	R:R:F276	R:R:V280	16.0796	3.93	No	No	0	1	5
25	L:L:K1	L:L:L5	18.0577	4.23	Yes	Yes	1	0	0
26	L:L:L5	L:L:S4	16.9253	3	Yes	No	0	0	0
27	L:L:S4	R:R:E288	18.3567	10.06	No	Yes	0	0	5
28	L:L:K1	R:R:H113	13.1578	5.24	Yes	Yes	1	0	6
29	R:R:D171	R:R:H113	29.8772	6.3	No	Yes	0	4	6
30	R:R:D171	R:R:R188	28.632	11.91	No	No	0	4	5
31	R:R:R188	R:R:Y190	15.6458	16.46	No	Yes	3	5	4
32	R:R:F292	R:R:Y45	14.9717	7.22	Yes	Yes	1	7	7
33	R:R:L91	R:R:Y45	15.3663	2.34	No	Yes	0	8	7
34	R:R:I48	R:R:L91	14.3761	2.85	No	No	0	7	8
35	L:L:K1	R:R:W94	24.8033	3.48	Yes	Yes	1	0	7
36	R:R:W94	R:R:Y116	52.2024	2.89	Yes	Yes	1	7	6
37	R:R:F87	R:R:Y116	44.6577	4.13	Yes	Yes	1	7	6
38	R:R:C295	R:R:F87	77.165	5.59	Yes	Yes	1	9	7
39	R:R:F292	R:R:F87	44.3439	8.57	Yes	Yes	1	7	7
40	R:R:C295	R:R:D84	89.411	4.67	Yes	Yes	1	9	9
41	R:R:D84	R:R:L80	100	4.07	Yes	No	1	9	9
42	R:R:I126	R:R:L80	99.4068	4.28	Yes	No	0	7	9
43	R:R:H79	R:R:I126	39.9196	5.3	No	Yes	0	9	7
44	R:R:H79	W:W:?1	29.9851	7.69	No	Yes	0	9	0
45	R:R:R70	W:W:?1	21.1167	12.11	No	Yes	0	6	0
46	R:R:D74	R:R:R70	16.1899	4.76	Yes	No	2	8	6
47	R:R:D74	R:R:R77	11.2974	3.57	Yes	Yes	2	8	8
48	R:R:I126	R:R:I130	54.7932	2.94	Yes	Yes	0	7	8
49	R:R:H79	R:R:K75	10.1208	2.62	No	No	0	9	6
50	R:R:I126	R:R:V160	14.0108	9.22	Yes	Yes	0	7	7
51	R:R:F87	R:R:H294	10.7925	10.18	Yes	Yes	1	7	9
52	R:R:H294	R:R:S123	17.0209	8.37	Yes	No	0	9	9
53	L:L:K1	R:R:D97	17.2684	4.15	Yes	No	0	0	5
54	R:R:D97	R:R:W102	14.9839	10.05	No	Yes	0	5	9
55	R:R:V112	R:R:W94	10.3954	4.9	No	Yes	0	5	7
56	R:R:F104	R:R:Y103	10.7827	2.06	Yes	No	0	7	3
57	R:R:V177	R:R:W102	11.8367	3.68	No	Yes	0	4	9
58	R:R:Y255	R:R:Y256	33.8383	4.96	Yes	Yes	0	7	8
59	R:R:H203	R:R:Y256	14.778	7.62	No	Yes	0	4	8
60	R:R:H203	R:R:Y121	13.1554	7.62	No	Yes	0	4	7
61	R:R:H294	R:R:W252	43.2899	12.7	Yes	Yes	0	9	9
62	R:R:I130	R:R:R134	44.3685	6.26	Yes	No	4	8	9
63	R:R:R134	R:R:Y219	43.415	6.17	No	Yes	0	9	8
64	R:R:S131	R:R:Y219	18.896	3.82	No	Yes	0	9	8
65	R:R:S131	R:R:V214	16.4399	1.62	No	No	0	9	6
66	R:R:C218	R:R:V214	15.2045	1.71	Yes	No	0	6	6
67	R:R:C218	R:R:Y135	10.214	5.38	Yes	Yes	0	6	8
68	R:R:F174	R:R:R188	11.7337	5.34	Yes	No	3	4	5
69	R:R:I204	R:R:I259	10.8366	5.89	No	No	0	5	5
70	R:R:T241	R:R:Y219	16.4399	4.99	Yes	Yes	0	7	8
71	R:R:I261	R:R:V280	10.7581	3.07	No	No	0	5	5
72	R:R:I257	R:R:I261	17.793	1.47	No	No	0	6	5
73	R:R:I257	R:R:L253	14.2437	4.28	No	No	0	6	5
74	R:R:G258	R:R:I284	12.3759	1.76	No	Yes	0	4	4
75	R:R:G258	R:R:I261	10.6258	1.76	No	No	0	4	5
76	R:R:L253	R:R:P254	10.6895	4.93	No	No	0	5	9
77	L:L:I51	L:L:I58	21.8619	4.42	Yes	Yes	0	0	0
78	L:L:I51	L:L:V49	26.4652	3.07	Yes	No	0	0	0
79	R:R:H113	R:R:W94	24.3204	7.41	Yes	Yes	1	6	7
80	R:R:W252	R:R:Y256	30.6322	5.79	Yes	Yes	0	9	8
81	R:R:C295	R:R:H294	17.6925	2.95	Yes	Yes	1	9	9
82	R:R:D84	R:R:S123	16.5086	2.94	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F13	R:R:K25	3.72	0	No	No	0	4	0	1
L:L:V49	R:R:K25	4.55	0	No	No	0	4	0	1
L:L:R47	R:R:E26	6.98	0	No	No	0	2	0	1
L:L:C11	R:R:P27	3.77	0	No	No	0	5	0	1
L:L:Q48	R:R:P27	3.16	0	No	No	0	5	0	1
L:L:R8	R:R:R30	3.2	0	No	No	0	5	0	1
R:R:L41	R:R:Y45	15.24	0	Yes	Yes	6	7	2	2
R:R:E288	R:R:Y45	4.49	1	Yes	Yes	5	7	1	2
R:R:F292	R:R:Y45	7.22	1	Yes	Yes	7	7	1	2
R:R:F87	R:R:Y116	4.13	1	Yes	Yes	7	6	2	2
R:R:F292	R:R:F87	8.57	1	Yes	Yes	7	7	1	2
R:R:T90	R:R:W94	4.85	0	No	Yes	6	7	2	1
R:R:V112	R:R:W94	4.9	0	No	Yes	5	7	2	1
R:R:H113	R:R:W94	7.41	1	Yes	Yes	6	7	1	1
R:R:W94	R:R:Y116	2.89	1	Yes	Yes	7	6	1	2
L:L:K1	R:R:W94	3.48	1	Yes	Yes	0	7	0	1
L:L:P2	R:R:W94	10.81	1	Yes	Yes	0	7	0	1
R:R:D97	R:R:W102	10.05	0	No	Yes	5	9	1	2
R:R:D97	R:R:I185	4.2	0	No	No	5	3	1	2
L:L:K1	R:R:D97	4.15	1	Yes	No	0	5	0	1
R:R:C109	R:R:W102	5.22	1	No	Yes	9	9	2	2
R:R:C186	R:R:W102	14.37	1	No	Yes	9	9	2	2
R:R:C109	R:R:H113	2.95	1	No	Yes	9	6	2	1
R:R:C109	R:R:C186	7.28	1	No	No	9	9	2	2
R:R:D171	R:R:H113	6.3	0	No	Yes	4	6	2	1
R:R:A175	R:R:H113	2.93	0	No	Yes	4	6	2	1
R:R:C186	R:R:H113	7.37	1	No	Yes	9	6	2	1
L:L:K1	R:R:H113	5.24	1	Yes	Yes	0	6	0	1
R:R:F292	R:R:Y116	5.16	1	Yes	Yes	7	6	1	2
R:R:F189	R:R:S178	6.61	8	No	No	3	1	1	1
L:L:N33	R:R:S178	5.96	8	No	No	0	1	0	1
L:L:K1	R:R:D187	11.06	1	Yes	No	0	3	0	1
L:L:S6	R:R:D187	5.89	0	No	No	0	3	0	1
L:L:Y7	R:R:D187	3.45	0	No	No	0	3	0	1
L:L:N33	R:R:F189	26.58	8	No	No	0	3	0	1
L:L:R12	R:R:D193	19.06	0	No	No	0	1	0	1
R:R:L266	R:R:V196	2.98	0	No	No	3	4	1	2
R:R:L266	R:R:V197	2.98	0	No	No	3	3	1	2
R:R:E288	R:R:Y255	4.49	1	Yes	Yes	5	7	1	2
L:L:R8	R:R:L266	7.29	0	No	No	0	3	0	1
L:L:F13	R:R:E268	18.66	0	No	No	0	2	0	1
R:R:I284	R:R:V280	3.07	0	Yes	No	4	5	1	2
L:L:V3	R:R:I284	3.07	0	No	Yes	0	4	0	1
L:L:S4	R:R:S285	4.89	0	No	No	0	5	0	1
R:R:E288	R:R:F292	8.16	1	Yes	Yes	5	7	1	1
L:L:S4	R:R:E288	10.06	0	No	Yes	0	5	0	1
L:L:P2	R:R:F292	2.89	1	Yes	Yes	0	7	0	1
R:R:D262	R:R:I284	2.8	0	No	Yes	5	4	2	1
R:R:H281	R:R:S285	2.79	0	No	No	4	5	2	1
R:R:G258	R:R:I284	1.76	0	No	Yes	4	4	2	1
R:R:A98	R:R:L41	1.58	0	No	Yes	5	6	1	2
L:L:L5	R:R:A98	1.58	1	Yes	No	0	5	0	1
R:R:E26	R:R:P27	1.57	0	No	No	2	5	1	1
L:L:P10	R:R:F29	1.44	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q66	R:R:R70	3.5	2	Yes	No	4	6	2	1
R:R:D74	R:R:Q66	5.22	2	Yes	Yes	8	4	2	2
R:R:D74	R:R:R70	4.76	2	Yes	No	8	6	2	1
R:R:R70	W:W:?1	12.11	2	No	Yes	6	0	1	0
R:R:L78	W:W:?1	8.28	0	No	Yes	5	0	1	0
R:R:H79	R:R:I126	5.3	0	No	Yes	9	7	1	2
R:R:H79	W:W:?1	7.69	0	No	Yes	9	0	1	0
R:R:V82	W:W:?1	7.43	0	No	Yes	5	0	1	0
R:R:S122	R:R:V160	3.23	6	No	Yes	7	7	2	2
R:R:S122	R:R:W161	8.65	6	No	Yes	7	9	2	1
R:R:I126	R:R:V160	9.22	0	Yes	Yes	7	7	2	2
R:R:Y157	W:W:?1	14.03	0	No	Yes	7	0	1	0
R:R:V160	R:R:W161	3.68	6	Yes	Yes	7	9	2	1
R:R:W161	W:W:?1	9.09	6	Yes	Yes	9	0	1	0
R:R:L165	W:W:?1	4.14	0	No	Yes	3	0	1	0
R:R:H79	R:R:K75	2.62	0	No	No	9	6	1	2
R:R:V118	R:R:W161	2.45	0	No	Yes	5	9	2	1
R:R:I60	R:R:L78	1.43	0	No	No	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8U4O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.87
Number of Linked Nodes	334
Number of Links	365
Number of Hubs	49
Number of Links mediated by Hubs	176
Number of Communities	11
Number of Nodes involved in Communities	52
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	90598
Length Of Smallest Path	3
Average Path Length	16.2882
Length of Longest Path	41
Minimum Path Strength	1.185
Average Path Strength	5.74868
Maximum Path Strength	17.575
Minimum Path Correlation	0.7
Average Path Correlation	0.951858
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	60.6335
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.2895
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • growth factor activity • signaling receptor activator activity • protein binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • chemokine activity • cytokine activity • CXCR chemokine receptor binding • cell adhesion molecule binding • protein-containing complex binding • integrin binding • response to peptide • response to stimulus • response to chemical • response to chemokine • response to cytokine • cellular response to cytokine stimulus • cellular response to chemokine • cellular component organization • cellular component biogenesis • cellular component assembly • protein-containing complex organization • protein-containing complex assembly • cellular process • integrin activation
Gene Ontology	Biological Process	• response to peptide • response to stimulus • response to chemical • response to chemokine • response to cytokine • cellular response to cytokine stimulus • cellular response to chemokine • cellular component organization • cellular component biogenesis • cellular component assembly • protein-containing complex organization • protein-containing complex assembly • cellular process • integrin activation • cellular component organization or biogenesis • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to ultrasound • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • signaling • biological regulation • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • telencephalon cell migration • central nervous system development • forebrain cell migration • anatomical structure development • cell migration • telencephalon development • cell motility • system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • defense response • response to stress • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • regulation of cellular component size • actin filament-based process • regulation of biological quality • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • regulation of actin polymerization or depolymerization • actin filament organization • regulation of organelle organization • organelle organization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • regulation of anatomical structure size • chemotaxis • taxis • locomotion • detection of external stimulus • system process • detection of stimulus involved in sensory perception of pain • nervous system process • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • cell chemotaxis • cellular response to chemical stimulus • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • regulation of response to external stimulus • positive regulation of biological process • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • positive regulation of cellular process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • regulation of response to stimulus • immune system process • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • regulation of calcium ion import • regulation of calcium ion transport • regulation of localization • positive regulation of calcium ion transport • positive regulation of calcium ion import • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • regulation of lymphocyte migration • positive regulation of lymphocyte migration • positive regulation of T cell migration • lymphocyte migration • regulation of T cell migration • T cell migration • cell adhesion • response to decreased oxygen levels • response to hypoxia • response to oxygen levels • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of biological process • regulation of cellular response to stress • regulation of signal transduction • regulation of intrinsic apoptotic signaling pathway in response to DNA damage • regulation of programmed cell death • regulation of intrinsic apoptotic signaling pathway • intracellular signal transduction • negative regulation of cell communication • cellular response to stress • regulation of intracellular signal transduction • negative regulation of apoptotic signaling pathway • regulation of response to stress • negative regulation of cellular process • intrinsic apoptotic signaling pathway in response to DNA damage • intrinsic apoptotic signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of programmed cell death • regulation of apoptotic process • cell death • negative regulation of signal transduction • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • apoptotic signaling pathway • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of apoptotic process • DNA damage response • regulation of cell communication • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • adult locomotory behavior • behavior • adult behavior • locomotory behavior • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • detection of mechanical stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • positive chemotaxis • positive regulation of positive chemotaxis • induction of positive chemotaxis • regulation of positive chemotaxis • immune response • axon extension • positive regulation of nervous system development • regulation of growth • axonogenesis • developmental growth • cell projection organization • regulation of cell differentiation • regulation of neurogenesis • neuron projection development • regulation of cell development • positive regulation of axon extension involved in axon guidance • positive regulation of developmental process • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cell differentiation • positive regulation of cell projection organization • positive regulation of developmental growth • neuron projection extension involved in neuron projection guidance • regulation of cell projection organization • positive regulation of cell development • developmental growth involved in morphogenesis • generation of neurons • positive regulation of multicellular organismal process • regulation of neuron projection development • positive regulation of cellular component organization • cellular developmental process • regulation of developmental process • plasma membrane bounded cell projection morphogenesis • cell development • cell growth • cell morphogenesis • regulation of axon extension • regulation of nervous system development • neurogenesis • regulation of axon extension involved in axon guidance • regulation of extent of cell growth • positive regulation of cell differentiation • regulation of axonogenesis • positive regulation of neurogenesis • regulation of multicellular organismal process • axon extension involved in axon guidance • positive regulation of axon extension • positive regulation of axonogenesis • regulation of anatomical structure morphogenesis • regulation of cell size • neuron projection extension • regulation of multicellular organismal development • regulation of developmental growth • plasma membrane bounded cell projection organization • developmental cell growth • growth • axon guidance • positive regulation of cell growth • axon development • regulation of cell growth • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • positive regulation of growth • neuron projection guidance • neuron development • regulation of plasma membrane bounded cell projection organization • CXCL12-activated CXCR4 signaling pathway • C-X-C chemokine receptor CXCR4 signaling pathway • negative regulation of locomotion • regulation of leukocyte adhesion to vascular endothelial cell • leukocyte cell-cell adhesion • negative regulation of cell adhesion • leukocyte tethering or rolling • negative regulation of leukocyte tethering or rolling • cell-cell adhesion • negative regulation of cellular extravasation • cellular extravasation • regulation of cell-cell adhesion • negative regulation of cell migration • regulation of cell adhesion • negative regulation of leukocyte adhesion to vascular endothelial cell • regulation of leukocyte tethering or rolling • negative regulation of leukocyte migration • negative regulation of leukocyte cell-cell adhesion • negative regulation of immune system process • leukocyte adhesion to vascular endothelial cell • negative regulation of cell-cell adhesion • regulation of leukocyte cell-cell adhesion • negative regulation of cell motility • regulation of cellular extravasation • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • secretion by cell • regulation of secretion by cell • catecholamine transport • positive regulation of secretion • signal release • secretion • positive regulation of catecholamine secretion • export from cell • cell-cell signaling • dopamine secretion • positive regulation of dopamine secretion • regulation of secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • vasculature development • regulation of vasculature development • circulatory system development • positive regulation of vasculature development • regulation of leukocyte apoptotic process • dendritic cell apoptotic process • negative regulation of dendritic cell apoptotic process • leukocyte apoptotic process • negative regulation of leukocyte apoptotic process • regulation of dendritic cell apoptotic process • positive regulation of cell adhesion • positive regulation of neuron differentiation • regulation of neuron differentiation • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • neuron migration • animal organ regeneration • regeneration • cell population proliferation • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of endothelial cell proliferation • regulation of cell population proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • circulatory system process • blood circulation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • extracellular matrix • external encapsulating structure • collagen-containing extracellular matrix • molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • protein binding • binding • myosin binding • small molecule binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • bioluminescence • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • neuron recognition • cellular developmental process • cell development • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron development • cell recognition • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • response to stimulus • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to ultrasound • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • forebrain development • telencephalon cell migration • forebrain cell migration • cell migration • telencephalon development • cell motility • apoptotic process • cell death • programmed cell death • epithelium development • endothelium development • tube development • morphogenesis of an endothelium • endothelial tube morphogenesis • morphogenesis of an epithelium • tissue development • tissue morphogenesis • anatomical structure morphogenesis • tube morphogenesis • epithelial tube morphogenesis • regulation of viral process • viral process • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • cellular response to stimulus • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • immune system process • mononuclear cell migration • leukocyte chemotaxis • detection of external stimulus • system process • detection of stimulus involved in sensory perception of pain • nervous system process • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • epithelial cell development • epithelial cell differentiation • regulation of growth • developmental growth • cell projection organization • neuron projection development • regulation of cell morphogenesis • positive regulation of developmental process • cell projection morphogenesis • neuron projection morphogenesis • positive regulation of developmental growth • developmental growth involved in morphogenesis • positive regulation of dendrite extension • regulation of cellular component organization • regulation of developmental process • plasma membrane bounded cell projection morphogenesis • cell growth • cell morphogenesis • dendrite extension • positive regulation of cellular process • regulation of anatomical structure morphogenesis • neuron projection extension • regulation of developmental growth • plasma membrane bounded cell projection organization • developmental cell growth • growth • regulation of dendrite extension • positive regulation of cell growth • regulation of cell growth • positive regulation of growth • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • detection of mechanical stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • signaling • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • C-X-C chemokine receptor CXCR4 signaling pathway • response to activity • regulation of cell motility • positive regulation of mesenchymal stem cell migration • positive regulation of cell migration • regulation of mesenchymal stem cell migration • mesenchymal stem cell migration • positive regulation of cell motility • regulation of cell migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • endothelial cell differentiation • angiogenesis • regulation of vasculature development • regulation of response to wounding • positive regulation of vascular wound healing • vascular wound healing • regulation of response to stress • regulation of multicellular organismal process • response to wounding • blood vessel development • positive regulation of response to wounding • wound healing • regulation of multicellular organismal development • blood vessel morphogenesis • angiogenesis involved in wound healing • positive regulation of angiogenesis • vasculature development • circulatory system development • positive regulation of vasculature development • positive regulation of wound healing • regulation of angiogenesis • regulation of wound healing • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • regulation of vascular wound healing • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • macrophage migration inhibitory factor signaling pathway • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of metabolic process • regulation of programmed cell death • response to tacrolimus • response to oxygen-containing compound • response to nitrogen compound • heart process • circulatory system process • cardiac muscle contraction • heart contraction • muscle contraction • muscle system process • blood circulation • striated muscle contraction • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • neuron migration • positive regulation of nervous system development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell leading edge • intracellular anatomical structure • cytoplasm • anchoring junction • cell junction • intracellular organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein-containing complex • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • endomembrane system • late endosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • cell division • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Interleukin 8-like chemokines • G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Interleukin 8-like chemokines • G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8U4O_nogp_Chain_R M K E P C F R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V S L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8YU7 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	To be published
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	To be published
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/β1/γ2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol		3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/β1/γ2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol		3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol		2.72	2024-03-13	10.1101/2024.02.09.579708
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	Cholesterol	-	3.2	2025-02-26	To be published
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	Cholesterol	-	3.01	2025-02-26	To be published
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE8 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	10.1126/science.1194396
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	10.1126/science.1194396
	3ODU (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		2.5	2010-10-27	10.1126/science.1194396

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