Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L23 3.9725446
2A:A:V34 6.2575
3A:A:L36 4.04477
4A:A:L37 5.792509
5A:A:E43 4.1825409
6A:A:I49 3.7225477
7A:A:F189 8.4225409
8A:A:F191 9.935475
9A:A:L194 5.9425474
10A:A:F196 7.635677
11A:A:M198 5.77577
12A:A:F199 7.10833615
13A:A:T202 5.59754179
14A:A:Q204 6.5175419
15A:A:S206 5.39418
16A:A:R208 4.06519
17A:A:K210 6.24143719
18A:A:W211 5.20875819
19A:A:I212 4.7625418
20A:A:H213 7.9425418
21A:A:C214 3.6375417
22A:A:F215 8.25419
23A:A:I221 4.405418
24A:A:I222 4.094577
25A:A:V225 5.6675437
26A:A:Y230 6.928538
27A:A:D231 6.57539
28A:A:M240 2.83406
29A:A:M243 3.428538
30A:A:H244 7.67434
31A:A:F250 7.662509
32A:A:N256 5.5125418
33A:A:W258 9.41833615
34A:A:F259 5.9575419
35A:A:I265 3.6725408
36A:A:F267 4.6145189
37A:A:L268 5.416538
38A:A:K270 4.4675439
39A:A:L273 4.3125436
40A:A:F274 4.878539
41A:A:L283 6.6375437
42A:A:C286 8.295436
43A:A:Y287 9.14429737
44A:A:Y290 9.018537
45A:A:Y296 6.455634
46A:A:Y302 12.98436
47A:A:I303 4.6825437
48A:A:F307 7.095638
49A:A:N311 5.74254148
50A:A:K317 5.74754147
51A:A:Y320 8.148336157
52A:A:T321 9.335435
53A:A:H322 10.2954189
54A:A:F323 4.7225434
55A:A:Q333 6.5675475
56A:A:F336 5.90857778
57A:A:I343 2.995407
58A:A:K345 5.324155
59A:A:L348 4.34409
60A:A:F354 5.97333605
61B:B:L14 3.48408
62B:B:I37 4.19333692
63B:B:V40 4.868593
64B:B:I43 3.7375403
65B:B:R48 4.5125447
66B:B:L51 6.906549
67B:B:H54 8.84333649
68B:B:Y59 8.984518
69B:B:M61 3.7925446
70B:B:W63 6.04714747
71B:B:L70 4.728545
72B:B:V71 4.225118
73B:B:D76 5.324549
74B:B:L79 4.66254117
75B:B:I80 9.585448
76B:B:I81 4.555117
77B:B:W82 8.93429749
78B:B:S84 4.39445
79B:B:N88 6.665407
80B:B:K89 5.59286749
81B:B:I93 5.722507
82B:B:W99 7.3825819
83B:B:Y105 4.521676116
84B:B:N110 7.8275414
85B:B:Y111 7.304514
86B:B:V112 4.5645118
87B:B:L117 3.82519
88B:B:C121 3.7375418
89B:B:I123 4.2425416
90B:B:Y124 6.166506
91B:B:L139 7.2425409
92B:B:H142 7.528519
93B:B:Y145 7.17333918
94B:B:C148 3.195456
95B:B:C149 3.368518
96B:B:F151 5.14833619
97B:B:L152 3.82453
98B:B:I157 5.055417
99B:B:V158 4.29455
100B:B:T159 5.842519
101B:B:S160 5.2456
102B:B:D163 7.424519
103B:B:C166 3.885458
104B:B:L168 3.982556
105B:B:W169 9.53667618
106B:B:Q176 7.61414
107B:B:F180 8.294557
108B:B:H183 7.97667659
109B:B:D186 5.8075419
110B:B:V187 5.024559
111B:B:L190 4.935455
112B:B:F199 7.34333659
113B:B:V200 7.255466
114B:B:S201 5.2625459
115B:B:C204 5.122517
116B:B:D205 5.265459
117B:B:K209 10.58456
118B:B:L210 4.836505
119B:B:W211 8.93333658
120B:B:Q220 7.3875467
121B:B:H225 8.61669
122B:B:D228 7.555419
123B:B:I232 5.8625468
124B:B:F235 6.72758126
125B:B:P236 6.7254127
126B:B:F241 8.062566
127B:B:T243 6.6575468
128B:B:D246 7.55419
129B:B:D247 8.552569
130B:B:T249 5.9025466
131B:B:R251 12.7425468
132B:B:F253 9.03466
133B:B:D258 11.38467
134B:B:M262 5.65404
135B:B:T263 6.23461
136B:B:Y264 6.422505
137B:B:F278 5.833336127
138B:B:R283 9.578599
139B:B:L284 5.4575405
140B:B:Y289 7.896676167
141B:B:D290 9.07406
142B:B:N295 5.9685166
143B:B:V296 4.645405
144B:B:W297 7.49754168
145B:B:L300 6.8496
146B:B:K301 6.05595
147B:B:L308 9.18407
148B:B:H311 9.25667689
149B:B:L318 3.852586
150B:B:V327 3.2125486
151B:B:W332 11.0143719
152B:B:D333 8.4125489
153B:B:F335 7.4925484
154B:B:L336 4.682547
155B:B:K337 8.8175486
156B:B:I338 4.388545
157B:B:W339 7.31167689
158G:G:L19 3.17754199
159G:G:R27 8.228568
160G:G:I28 3.77404
161G:G:M38 4.245494
162G:G:Y40 9.74254126
163G:G:D48 7.23599
164G:G:L51 5.384596
165G:G:N59 5.5925449
166G:G:F61 5.035848
167R:R:F40 7.02405
168R:R:L41 4.2675406
169R:R:Y45 5.202527
170R:R:M63 5.88754106
171R:R:Q66 4.9454104
172R:R:K67 4.23486
173R:R:R70 4.1685106
174R:R:D74 6.1645108
175R:R:Y76 5.99627
176R:R:R77 5.8854108
177R:R:H79 7.175429
178R:R:L80 5.416529
179R:R:D84 6.672529
180R:R:F87 7.55429727
181R:R:V88 3.525406
182R:R:F93 8.42754136
183R:R:W102 9.913336139
184R:R:F104 7.286137
185R:R:L108 4.7485135
186R:R:H113 5.64506
187R:R:Y116 5.158526
188R:R:L120 4.534527
189R:R:Y121 5.78286727
190R:R:I126 4.31407
191R:R:F129 4.855625
192R:R:I130 5.32428
193R:R:R134 6.88167629
194R:R:Y135 7.57754238
195R:R:H140 6.32754236
196R:R:R148 7.755406
197R:R:L151 4.295424
198R:R:V156 5.386525
199R:R:V160 5.24527
200R:R:T168 4.695406
201R:R:D171 6.55404
202R:R:F174 7.0975424
203R:R:Y190 7.895624
204R:R:P191 4.9675425
205R:R:W195 6.364525
206R:R:F199 5.54167625
207R:R:Q200 6.25405
208R:R:H203 7.2275424
209R:R:I204 3.9075405
210R:R:P211 3.4325409
211R:R:Y219 7.37167628
212R:R:L226 2.8025408
213R:R:T241 5.315407
214R:R:L244 4.585427
215R:R:F248 7.0725429
216R:R:W252 6.5975829
217R:R:Y255 5.99571727
218R:R:Y256 8.01667628
219R:R:F276 4.6225401
220R:R:F292 9.7175427
221R:R:H294 8.9025429
222R:R:C295 5.61429
223R:R:N298 6.67429
224R:R:L301 2.4825407
225R:R:Y302 5.66286729
226R:R:F304 3.4845106
227R:R:F309 7.2825108
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 24.39594.86NoYes076
2B:B:C317 B:B:S316 24.50223.44NoNo079
3B:B:S316 B:B:W332 24.60926.18NoYes099
4A:A:W258 B:B:W332 15.89923.75YesYes159
5A:A:N256 A:A:W258 27.969110.17YesYes185
6A:A:F259 A:A:N256 25.38264.83YesYes198
7A:A:F259 A:A:I221 25.51658.79YesYes198
8A:A:I221 A:A:I264 29.95942.94YesNo086
9A:A:F250 A:A:I264 30.04553.77YesNo096
10A:A:F250 A:A:F307 65.621510.72YesYes098
11A:A:F307 A:A:M243 41.18863.73YesYes388
12A:A:I303 A:A:M243 49.90892.92YesYes378
13A:A:I303 A:A:L283 49.85024.28YesYes377
14A:A:L283 A:A:Y230 91.38735.86YesYes378
15A:A:K277 A:A:Y230 99.83777.17NoYes398
16A:A:K277 A:A:S228 1003.06NoNo399
17A:A:K270 A:A:S228 99.70646.12YesNo399
18A:A:E43 A:A:K270 99.78622.7YesYes099
19A:A:C224 A:A:E43 97.95144.56NoYes079
20A:A:C224 A:A:I49 96.46973.27NoYes077
21A:A:I49 A:A:M198 18.18692.92YesYes777
22A:A:L36 A:A:M198 11.66414.24YesYes777
23A:A:L36 A:A:V34 11.21072.98YesYes775
24A:A:V339 A:A:V34 10.5928.02NoYes785
25A:A:I343 A:A:V339 26.26943.07YesNo078
26A:A:I343 A:A:N347 25.25484.25YesNo078
27A:A:N347 R:R:A137 24.8654.69NoNo088
28R:R:A137 R:R:R148 24.47536.91NoYes086
29A:A:F307 A:A:M247 41.65068.71YesNo086
30A:A:M247 A:A:Y287 41.63448.38NoYes067
31A:A:L283 A:A:Y287 41.75477.03YesYes377
32A:A:I222 A:A:I49 78.18634.42YesYes777
33A:A:I222 A:A:L36 11.58312.85YesYes777
34A:A:F196 A:A:L36 11.87076.09YesYes777
35A:A:F196 A:A:V339 16.06863.93YesNo778
36A:A:I253 A:A:R208 17.49013.76NoYes089
37A:A:A41 A:A:L249 35.01423.15NoNo079
38A:A:L249 A:A:R208 52.36243.64NoYes099
39A:A:A41 A:A:S246 35.22473.42NoNo079
40B:B:G162 B:B:Y145 18.48878.69NoYes198
41B:B:G162 B:B:S161 18.19863.71NoNo199
42A:A:W211 B:B:Y145 71.51645.79YesYes198
43A:A:K210 B:B:Y145 32.65783.58YesYes198
44A:A:K210 B:B:D246 30.28525.53YesYes199
45A:A:I222 A:A:I265 66.67694.42YesYes078
46A:A:F223 A:A:L249 17.51897.31NoNo099
47A:A:F223 A:A:I253 17.58356.28NoNo098
48A:A:S246 A:A:V225 17.70474.85NoYes397
49A:A:A338 A:A:I265 66.86733.25NoYes068
50A:A:A338 A:A:Y320 66.80488.01NoYes067
51A:A:D341 A:A:Y320 65.32799.2NoYes1587
52A:A:D341 R:R:K234 65.30786.91NoNo087
53R:R:K234 R:R:L226 65.11982.82NoYes078
54A:A:L348 R:R:L226 26.32122.77YesYes098
55A:A:L348 A:A:L353 26.38984.15YesNo097
56R:R:I222 R:R:L226 38.32462.85NoYes088
57R:R:S81 R:R:V59 12.98238.08NoNo098
58R:R:N56 R:R:S81 14.3452.98NoNo099
59R:R:D84 R:R:N56 24.588412.12YesNo099
60R:R:D84 R:R:L80 25.754.07YesYes299
61R:R:L80 R:R:Y302 25.57383.52YesYes299
62R:R:R134 R:R:Y302 25.4767.2YesYes299
63A:A:L353 R:R:R134 26.29149.72NoYes079
64R:R:D84 R:R:N298 25.41248.08YesYes299
65R:R:N298 R:R:Y302 25.56583.49YesYes299
66R:R:Y219 R:R:Y302 25.46422.98YesYes289
67R:R:T241 R:R:Y219 38.22426.24YesYes078
68R:R:I222 R:R:T241 38.18513.04NoYes087
69B:B:D246 B:B:S227 30.00855.89YesNo096
70B:B:D247 B:B:S227 29.71082.94YesNo096
71B:B:D247 B:B:H225 27.01277.56YesYes699
72B:B:H225 B:B:T243 25.52018.21YesYes698
73B:B:F253 B:B:T243 18.01717.78YesYes668
74B:B:F222 B:B:F253 17.127310.72NoYes686
75B:B:F222 B:B:Q220 16.8347.03NoYes687
76B:B:D258 B:B:Q220 11.142311.75YesYes677
77B:B:I18 G:G:A23 11.74843.25NoNo078
78B:B:Q17 G:G:A23 10.84493.03NoNo048
79B:B:D290 B:B:R314 12.456523.82YesNo068
80B:B:S147 B:B:Y145 23.82643.82NoYes098
81B:B:S147 B:B:S160 23.53114.89NoYes096
82B:B:H142 B:B:S161 13.404813.95YesNo199
83B:B:H142 B:B:W169 10.43786.35YesYes198
84B:B:S160 B:B:V187 10.79216.46YesYes569
85R:R:C295 R:R:D84 26.24644.67YesYes299
86R:R:C295 R:R:F87 23.10546.98YesYes297
87R:R:S131 R:R:Y219 12.406713.99NoYes098
88R:R:I215 R:R:S131 12.14127.74NoNo079
89R:R:F248 R:R:I215 12.05787.54YesNo097
90R:R:F248 R:R:W252 11.66587.02YesYes299
91R:R:D133 R:R:R148 17.19914.29NoYes086
92R:R:D133 R:R:Y76 16.80910.34NoYes087
93R:R:F87 R:R:Y116 14.17826.19YesYes276
94R:R:W94 R:R:Y116 16.47375.79NoYes276
95R:R:H113 R:R:W94 16.05489.52YesNo067
96A:A:F223 A:A:F250 35.126913.93NoYes099
97A:A:F307 A:A:S246 17.62613.96YesNo389
98A:A:R208 A:A:W211 68.90674YesYes199
99A:A:W258 B:B:R314 11.79045YesNo158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8U4N
Class A
SubFamily Protein
Type Chemokine
SubType CXCR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.72
Date 2024-03-13
D.O.I. doi.org/10.1101/2024.02.09.579708
Net Summary
Imin 2.77
Number of Linked Nodes 853
Number of Links 1142
Number of Hubs 227
Number of Links mediated by Hubs 792
Number of Communities 23
Number of Nodes involved in Communities 310
Number of Links involved in Communities 499
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 4976722
Length Of Smallest Path 3
Average Path Length 36.4147
Length of Longest Path 61
Minimum Path Strength 1.28
Average Path Strength 5.80341
Maximum Path Strength 23.7267
Minimum Path Correlation 0.7
Average Path Correlation 0.992111
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 33.1557
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.7721
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • coreceptor activity   • signaling receptor activity   • cytoskeletal protein binding   • myosin light chain binding   • protein binding   • binding   • myosin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-X-C motif chemokine 12 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • virus receptor activity   • exogenous protein binding   • C-C chemokine receptor activity   • ubiquitin binding   • ubiquitin-like protein binding   • actin binding   • bioluminescence   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development
Gene OntologyBiological Process• bioluminescence   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion   • biological regulation   • apoptotic process   • cell death   • programmed cell death   • membrane organization   • cellular component organization   • myelination   • myelin maintenance   • axon ensheathment   • ensheathment of neurons   • plasma membrane organization   • cellular component organization or biogenesis   • endomembrane system organization   • cell chemotaxis   • cellular response to stimulus   • chemotaxis   • dendritic cell chemotaxis   • response to stimulus   • response to external stimulus   • leukocyte migration   • dendritic cell migration   • cellular response to chemical stimulus   • taxis   • immune system process   • response to chemical   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • locomotion   • response to decreased oxygen levels   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • neurogenesis   • cellular developmental process   • cell differentiation   • regulation of response to external stimulus   • regulation of chemotaxis   • regulation of response to stimulus   • regulation of locomotion   • immune response   • cell surface receptor signaling pathway   • chemokine (C-X-C motif) ligand 12 signaling pathway   • signaling   • CXCL12-activated CXCR4 signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • cell communication   • response to peptide   • G protein-coupled receptor signaling pathway   • cellular response to cytokine stimulus   • signal transduction   • C-X-C chemokine receptor CXCR4 signaling pathway   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • regulation of multicellular organismal development   • regulation of developmental process   • positive regulation of biological process   • vasculature development   • regulation of vasculature development   • circulatory system development   • positive regulation of developmental process   • positive regulation of vasculature development   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of macrophage migration inhibitory factor signaling pathway   • positive regulation of response to cytokine stimulus   • positive regulation of response to stimulus   • macrophage migration inhibitory factor signaling pathway   • positive regulation of cellular process   • regulation of signaling   • regulation of macrophage migration inhibitory factor signaling pathway   • regulation of cytokine-mediated signaling pathway   • regulation of response to cytokine stimulus   • regulation of cell communication   • positive regulation of cytokine-mediated signaling pathway   • positive regulation of signaling   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • regulation of metabolic process   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • positive regulation of cell motility   • regulation of cell migration   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to external biotic stimulus   • response to virus   • response to biotic stimulus   • defense response   • inflammatory response   • positive regulation of nervous system development   • cell development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of gliogenesis   • positive regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • gliogenesis   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • oligodendrocyte differentiation   • glial cell differentiation   • regulation of oligodendrocyte differentiation   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell leading edge   • intracellular anatomical structure   • cytoplasm   • anchoring junction   • cell junction   • intracellular organelle   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • lysosome   • protein-containing complex   • cytoplasmic vesicle   • intracellular vesicle   • early endosome   • endosome   • endomembrane system   • late endosome   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • synapse   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • ciliary basal body
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8U4N_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMTGIVET HFTFKDLHF KMFDVTAQR SERKKWIHC FEGVTAIIF 
CVALSDYDL VLAEDEEMN RMHASMKLF DSICNNKWF TDTSIILFL 
NKKDLFEEK IKKSPLTIC YPEYAGSNT YEEAAAYIQ CQFEDLNKR 
KDTKEIYTH FTCSTDTKN VQFVFDAVT DVIIKNNLK DCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8U4N_Chain_B
QLRQEAEQL KNQIRDARK ACADATLSQ ITNNIDPVG RIQMRTRRT 
LRGHLAKIY AMHWGTDSR LLVSASQDG KLIIWDSYT TNKVHAIPL 
RSSWVMTCA YAPSGNYVA CGGLDNICS IYNLKTREG NVRVSRELA 
GHTGYLSCC RFLDDNQIV TSSGDTTCA LWDIETGQQ TTTFTGHTG 
DVMSLSLAP DTRLFVSGA CDASAKLWD VREGMCRQT FTGHESDIN 
AICFFPNGN AFATGSDDA TCRLFDLRA DQELMTYSH DNIICGITS 
VSFSKSGRL LLAGYDDFN CNVWDALKA DRAGVLAGH DNRVSCLGV 
TDDGMAVAT GSWDSFLKI WN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8U4N_Chain_G
ARKLVEQLK MEANIDRIK VSKAAADLM AYCEAHAKE DPLLTPVPA 
SENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP61073
Sequence
>8U4N_Chain_R
FNKIFLPTI YSIIFLTGI VGNGLVILV MGYQKKLRS MTDKYRLHL 
SVADLLFVI TLPFWAVDA VANWYFGNF LCKAVHVIY TVSLYSSVL 
ILAFISLDR YLAIVHATN SQRPRKLLA EKVVYVGVW IPALLLTIP 
DFIFANVSE ADDRYICDR FYPNDLWVV VFQFQHIMV GLILPGIVI 
LSCYCIIIS KLSHSKGHQ KRKALKTTV ILILAFFAC WLPYYIGIS 
IDSFILLEI IKQGCEFEN TVHKWISIT EALAFFHCC LNPILYAFL 
GAKFKTSAQ HALT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-05doi.org/10.1016/j.celrep.2025.115255
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens--2.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-3.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.12024-03-13doi.org/10.1101/2024.02.09.579708
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-27doi.org/10.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-27doi.org/10.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-27doi.org/10.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-11doi.org/10.1126/science.1261064
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116--3.012025-02-26doi.org/10.1073/pnas.2425795122
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070--3.22025-02-26doi.org/10.1073/pnas.2425795122
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122




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