psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:E14	A:A:K10	12.15	No	No	0	3	3
2	A:A:K17	A:A:V13	6.07	No	No	0	4	3
3	A:A:V13	B:B:N88	7.39	No	Yes	0	3	7
4	A:A:E14	A:A:K17	6.75	No	No	0	3	4
5	A:A:S16	B:B:N88	8.94	No	Yes	0	7	7
6	A:A:S16	B:B:K89	3.06	No	Yes	0	7	9
7	A:A:I19	A:A:M18	2.92	No	No	0	9	4
8	A:A:I19	B:B:K89	7.27	No	Yes	0	9	9
9	A:A:D20	A:A:R24	10.72	No	No	0	6	3
10	A:A:D20	B:B:K89	8.3	No	Yes	0	6	9
11	A:A:R21	A:A:R24	7.46	No	No	0	4	3
12	A:A:E25	A:A:N22	7.89	No	No	0	4	4
13	A:A:L23	B:B:K78	5.64	Yes	No	0	6	8
14	A:A:L23	B:B:I80	4.28	Yes	Yes	4	6	8
15	A:A:L23	B:B:K89	2.82	Yes	Yes	4	6	9
16	A:A:L23	B:B:A92	3.15	Yes	No	0	6	6
17	A:A:D26	B:B:K78	8.3	No	No	0	5	8
18	A:A:E28	R:R:K149	5.4	No	No	0	4	6
19	A:A:R32	R:R:Q145	4.67	No	No	0	4	5
20	A:A:R32	R:R:R146	14.93	No	No	0	4	5
21	A:A:E33	A:A:H195	13.54	No	No	0	6	4
22	A:A:E33	A:A:K197	4.05	No	No	0	6	6
23	A:A:L36	A:A:V34	2.98	Yes	Yes	7	7	5
24	A:A:L194	A:A:V34	4.47	Yes	Yes	7	4	5
25	A:A:F196	A:A:V34	9.18	Yes	Yes	7	7	5
26	A:A:T219	A:A:V34	6.35	No	Yes	0	7	5
27	A:A:V339	A:A:V34	8.02	No	Yes	7	8	5
28	A:A:F199	A:A:K35	9.93	Yes	No	0	5	9
29	A:A:K35	A:A:V218	3.04	No	No	0	9	9
30	A:A:F196	A:A:L36	6.09	Yes	Yes	7	7	7
31	A:A:L36	A:A:M198	4.24	Yes	Yes	7	7	7
32	A:A:I222	A:A:L36	2.85	Yes	Yes	7	7	7
33	A:A:L37	A:A:L39	5.54	Yes	No	0	9	9
34	A:A:L37	A:A:V201	2.98	Yes	No	0	9	9
35	A:A:F215	A:A:L37	14.61	Yes	Yes	0	9	9
36	A:A:L37	A:A:V218	2.98	Yes	No	0	9	9
37	A:A:I221	A:A:L37	2.85	Yes	Yes	0	8	9
38	A:A:I49	A:A:L38	4.28	Yes	No	7	7	8
39	A:A:L38	A:A:M198	12.72	No	Yes	7	8	7
40	A:A:I222	A:A:L38	5.71	Yes	No	7	7	8
41	A:A:I253	A:A:L39	2.85	No	No	0	8	9
42	A:A:A41	A:A:S246	3.42	No	No	0	7	9
43	A:A:A41	A:A:L249	3.15	No	No	0	7	9
44	A:A:E43	A:A:G45	4.91	Yes	No	0	9	9
45	A:A:C47	A:A:E43	4.56	No	Yes	0	9	9
46	A:A:C224	A:A:E43	4.56	No	Yes	0	7	9
47	A:A:K46	A:A:S44	6.12	No	No	16	9	9
48	A:A:S44	A:A:T202	3.2	No	Yes	16	9	9
49	A:A:K46	A:A:T202	4.5	No	Yes	16	9	9
50	A:A:C47	A:A:T48	5.07	No	No	0	9	9
51	A:A:C47	A:A:N269	6.3	No	No	0	9	9
52	A:A:I49	A:A:M198	2.92	Yes	Yes	7	7	7
53	A:A:I222	A:A:I49	4.42	Yes	Yes	7	7	7
54	A:A:C224	A:A:I49	3.27	No	Yes	0	7	7
55	A:A:N331	A:A:Q52	5.28	No	No	0	8	9
56	A:A:Q52	A:A:V332	2.87	No	No	0	9	7
57	A:A:F189	A:A:M53	6.22	Yes	No	0	9	8
58	A:A:T182	B:B:N119	4.39	No	No	0	7	9
59	A:A:G183	B:B:N119	5.09	No	No	0	9	9
60	A:A:F199	A:A:I184	5.02	Yes	No	2	5	9
61	A:A:I184	A:A:V201	3.07	No	No	0	9	9
62	A:A:I184	B:B:W99	7.05	No	Yes	2	9	9
63	A:A:E186	A:A:F199	5.83	No	Yes	2	9	5
64	A:A:E186	B:B:S97	2.87	No	No	2	9	8
65	A:A:E186	B:B:W99	6.54	No	Yes	2	9	9
66	A:A:H188	A:A:H195	5.97	No	No	0	3	4
67	A:A:H188	A:A:K197	10.48	No	No	0	3	6
68	A:A:F189	A:A:F196	16.08	Yes	Yes	0	9	7
69	A:A:F189	A:A:M198	7.46	Yes	Yes	0	9	7
70	A:A:F189	A:A:V332	3.93	Yes	No	0	9	7
71	A:A:H195	A:A:T190	9.58	No	No	0	4	3
72	A:A:F191	A:A:K192	13.65	Yes	No	7	5	4
73	A:A:F191	A:A:V332	10.49	Yes	No	0	5	7
74	A:A:F191	A:A:Q333	7.03	Yes	Yes	7	5	5
75	A:A:F191	A:A:F336	8.57	Yes	Yes	7	5	8
76	A:A:K192	A:A:Q333	5.42	No	Yes	7	4	5
77	A:A:F336	A:A:K192	7.44	Yes	No	7	8	4
78	A:A:F196	A:A:L194	7.31	Yes	Yes	7	7	4
79	A:A:F336	A:A:L194	6.09	Yes	Yes	7	8	4
80	A:A:L194	R:R:T142	5.9	Yes	No	0	4	5
81	A:A:F196	A:A:F336	3.22	Yes	Yes	7	7	8
82	A:A:F196	A:A:V339	3.93	Yes	No	7	7	8
83	A:A:F199	A:A:F215	5.36	Yes	Yes	2	5	9
84	A:A:F199	B:B:W99	14.03	Yes	Yes	2	5	9
85	A:A:D200	A:A:T202	13.01	No	Yes	0	9	9
86	A:A:V201	A:A:W211	7.36	No	Yes	0	9	9
87	A:A:Q204	A:A:S206	4.33	Yes	Yes	2	9	8
88	A:A:Q204	A:A:W211	9.86	Yes	Yes	2	9	9
89	A:A:Q204	B:B:L117	3.99	Yes	Yes	2	9	9
90	A:A:Q204	B:B:Y145	7.89	Yes	Yes	2	9	8
91	A:A:S206	A:A:W211	3.71	Yes	Yes	2	8	9
92	A:A:S206	B:B:Y145	7.63	Yes	Yes	2	8	8
93	A:A:S206	B:B:D186	5.89	Yes	Yes	2	8	9
94	A:A:E207	A:A:K209	6.75	No	No	0	9	8
95	A:A:R208	A:A:W211	4	Yes	Yes	2	9	9
96	A:A:I212	A:A:R208	6.26	Yes	Yes	2	8	9
97	A:A:L249	A:A:R208	3.64	No	Yes	0	9	9
98	A:A:I253	A:A:R208	3.76	No	Yes	0	8	9
99	A:A:K209	A:A:K210	4.31	No	Yes	2	8	9
100	A:A:K209	B:B:D228	4.15	No	Yes	2	8	9
101	A:A:K210	B:B:Y145	3.58	Yes	Yes	2	9	8
102	A:A:K210	B:B:M188	11.52	Yes	No	2	9	8
103	A:A:K210	B:B:C204	4.85	Yes	Yes	2	9	7
104	A:A:K210	B:B:D228	8.3	Yes	Yes	2	9	9
105	A:A:K210	B:B:N230	5.6	Yes	No	2	9	9
106	A:A:K210	B:B:D246	5.53	Yes	Yes	2	9	9
107	A:A:I212	A:A:W211	3.52	Yes	Yes	2	8	9
108	A:A:F215	A:A:W211	4.01	Yes	Yes	2	9	9
109	A:A:W211	B:B:L117	3.42	Yes	Yes	2	9	9
110	A:A:W211	B:B:Y145	5.79	Yes	Yes	2	9	8
111	A:A:I212	A:A:N256	4.25	Yes	Yes	2	8	8
112	A:A:F259	A:A:I212	5.02	Yes	Yes	2	9	8
113	A:A:C214	A:A:H213	2.95	Yes	Yes	2	7	8
114	A:A:H213	A:A:W258	12.7	Yes	Yes	2	8	5
115	A:A:H213	B:B:Y59	8.71	Yes	Yes	2	8	8
116	A:A:H213	B:B:W332	7.41	Yes	Yes	2	8	9
117	A:A:C214	B:B:Y59	5.38	Yes	Yes	2	7	8
118	A:A:C214	B:B:Q75	3.05	Yes	No	2	7	9
119	A:A:C214	B:B:L117	3.17	Yes	Yes	2	7	9
120	A:A:F215	B:B:W99	9.02	Yes	Yes	2	9	9
121	A:A:E216	A:A:W258	9.81	No	Yes	0	7	5
122	A:A:E216	B:B:K57	6.75	No	No	0	7	9
123	A:A:A220	A:A:I265	3.25	No	Yes	0	8	8
124	A:A:F259	A:A:I221	8.79	Yes	Yes	2	9	8
125	A:A:I221	A:A:T262	3.04	Yes	No	2	8	7
126	A:A:I221	A:A:I264	2.94	Yes	No	0	8	6
127	A:A:I222	A:A:I265	4.42	Yes	Yes	0	7	8
128	A:A:I222	A:A:V335	3.07	Yes	No	0	7	8
129	A:A:F223	A:A:L249	7.31	No	No	0	9	9
130	A:A:F223	A:A:F250	13.93	No	Yes	0	9	9
131	A:A:F223	A:A:I253	6.28	No	No	0	9	8
132	A:A:C224	A:A:N269	6.3	No	No	0	7	9
133	A:A:M243	A:A:V225	3.04	Yes	Yes	3	8	7
134	A:A:S246	A:A:V225	4.85	No	Yes	3	9	7
135	A:A:L268	A:A:V225	2.98	Yes	Yes	3	8	7
136	A:A:F307	A:A:V225	11.8	Yes	Yes	3	8	7
137	A:A:A226	A:A:D229	6.18	No	No	0	8	8
138	A:A:A226	A:A:K270	4.82	No	Yes	0	8	9
139	A:A:L227	A:A:L268	11.07	No	Yes	0	7	8
140	A:A:F274	A:A:L227	7.31	Yes	No	0	9	7
141	A:A:I303	A:A:L227	4.28	Yes	No	0	7	7
142	A:A:K270	A:A:S228	6.12	Yes	No	3	9	9
143	A:A:L273	A:A:S228	9.01	Yes	No	3	6	9
144	A:A:K277	A:A:S228	3.06	No	No	3	9	9
145	A:A:D229	A:A:R242	10.72	No	No	0	8	9
146	A:A:D231	A:A:Y230	9.2	Yes	Yes	3	9	8
147	A:A:F274	A:A:Y230	5.16	Yes	Yes	3	9	8
148	A:A:K277	A:A:Y230	7.17	No	Yes	3	9	8
149	A:A:I278	A:A:Y230	7.25	No	Yes	3	6	8
150	A:A:L283	A:A:Y230	5.86	Yes	Yes	3	7	8
151	A:A:D231	A:A:L232	4.07	Yes	No	0	9	8
152	A:A:D231	A:A:K277	12.44	Yes	No	3	9	9
153	A:A:D231	A:A:S281	2.94	Yes	No	0	9	7
154	A:A:D231	A:A:I285	4.2	Yes	No	0	9	3
155	A:A:L232	A:A:R242	9.72	No	No	0	8	9
156	A:A:E236	A:A:L234	3.98	No	No	0	9	8
157	A:A:L234	A:A:M240	4.24	No	Yes	0	8	6
158	A:A:D237	A:A:M240	4.16	No	Yes	0	8	6
159	A:A:M243	A:A:N241	4.21	Yes	No	3	8	9
160	A:A:H244	A:A:N241	16.58	Yes	No	3	4	9
161	A:A:C286	A:A:N241	6.3	Yes	No	3	6	9
162	A:A:C286	A:A:M243	3.24	Yes	Yes	3	6	8
163	A:A:I303	A:A:M243	2.92	Yes	Yes	3	7	8
164	A:A:F307	A:A:M243	3.73	Yes	Yes	3	8	8
165	A:A:H244	A:A:M247	3.94	Yes	No	0	4	6
166	A:A:C286	A:A:H244	8.85	Yes	Yes	3	6	4
167	A:A:F307	A:A:S246	3.96	Yes	No	3	8	9
168	A:A:M247	A:A:Y287	8.38	No	Yes	0	6	7
169	A:A:F307	A:A:M247	8.71	Yes	No	0	8	6
170	A:A:F250	A:A:I264	3.77	Yes	No	0	9	6
171	A:A:F250	A:A:F307	10.72	Yes	Yes	0	9	8
172	A:A:F250	A:A:L310	4.87	Yes	No	0	9	4
173	A:A:F250	A:A:I319	5.02	Yes	No	0	9	5
174	A:A:D251	A:A:N255	8.08	No	No	13	5	8
175	A:A:D251	A:A:L310	13.57	No	No	0	5	4
176	A:A:D251	A:A:K312	4.15	No	No	13	5	5
177	A:A:C254	A:A:N255	4.72	No	No	13	5	8
178	A:A:C254	A:A:N311	4.72	No	Yes	13	5	8
179	A:A:C254	A:A:K317	6.47	No	Yes	13	5	7
180	A:A:K312	A:A:N255	11.19	No	No	13	5	8
181	A:A:K257	A:A:N256	2.8	No	Yes	2	4	8
182	A:A:N256	A:A:W258	10.17	Yes	Yes	2	8	5
183	A:A:F259	A:A:N256	4.83	Yes	Yes	2	9	8
184	A:A:K257	A:A:W258	15.08	No	Yes	2	4	5
185	A:A:W258	B:B:R314	5	Yes	No	2	5	8
186	A:A:W258	B:B:W332	3.75	Yes	Yes	2	5	9
187	A:A:F259	A:A:T262	5.19	Yes	No	2	9	7
188	A:A:D261	A:A:T260	4.34	No	No	0	4	3
189	A:A:R313	A:A:T260	11.64	No	No	0	4	3
190	A:A:D261	A:A:T262	2.89	No	No	0	4	7
191	A:A:S263	A:A:Y320	5.09	No	Yes	14	7	7
192	A:A:S263	A:A:V342	3.23	No	No	14	7	7
193	A:A:I264	A:A:K317	5.82	No	Yes	0	6	7
194	A:A:F267	A:A:I265	3.77	Yes	Yes	0	9	8
195	A:A:A338	A:A:I265	3.25	No	Yes	0	6	8
196	A:A:L266	A:A:L268	2.77	No	Yes	3	9	8
197	A:A:F307	A:A:L266	3.65	Yes	No	3	8	9
198	A:A:L266	A:A:T321	10.32	No	Yes	3	9	5
199	A:A:F267	A:A:H322	5.66	Yes	Yes	17	9	9
200	A:A:F267	A:A:T324	6.49	Yes	No	0	9	9
201	A:A:F267	A:A:F334	3.22	Yes	No	17	9	3
202	A:A:F267	A:A:V335	3.93	Yes	No	0	9	8
203	A:A:L268	A:A:T321	2.95	Yes	Yes	3	8	5
204	A:A:F323	A:A:L268	7.31	Yes	Yes	3	4	8
205	A:A:N269	A:A:T324	7.31	No	No	0	9	9
206	A:A:K270	A:A:L273	4.23	Yes	Yes	3	9	6
207	A:A:K271	A:A:Y296	7.17	No	Yes	0	5	4
208	A:A:F274	A:A:I278	5.02	Yes	No	3	9	6
209	A:A:F274	A:A:Y296	4.13	Yes	Yes	3	9	4
210	A:A:A299	A:A:F274	2.77	No	Yes	0	7	9
211	A:A:E275	A:A:K279	5.4	No	No	0	5	2
212	A:A:E275	A:A:Y296	13.47	No	Yes	0	5	4
213	A:A:K279	A:A:K280	4.31	No	No	0	2	1
214	A:A:P282	A:A:S281	3.56	No	No	0	5	7
215	A:A:P282	A:A:T284	5.25	No	No	0	5	4
216	A:A:L283	A:A:Y287	7.03	Yes	Yes	3	7	7
217	A:A:L283	A:A:Y290	9.38	Yes	Yes	3	7	7
218	A:A:I303	A:A:L283	4.28	Yes	Yes	3	7	7
219	A:A:C286	A:A:Y287	14.79	Yes	Yes	3	6	7
220	A:A:Y287	A:A:Y302	13.9	Yes	Yes	3	7	6
221	A:A:I303	A:A:Y287	7.25	Yes	Yes	3	7	7
222	A:A:Q306	A:A:Y287	11.27	No	Yes	3	5	7
223	A:A:G292	A:A:Y290	7.24	No	Yes	3	7	7
224	A:A:E298	A:A:Y290	5.61	No	Yes	3	4	7
225	A:A:A299	A:A:Y290	4	No	Yes	0	7	7
226	A:A:Y290	A:A:Y302	18.86	Yes	Yes	3	7	6
227	A:A:E298	A:A:G292	4.91	No	No	3	4	7
228	A:A:S293	A:A:T295	4.8	No	No	0	3	5
229	A:A:E298	A:A:S293	7.19	No	No	0	4	3
230	A:A:E297	A:A:Y296	4.49	No	Yes	0	4	4
231	A:A:A300	A:A:Y296	5.34	No	Yes	3	5	4
232	A:A:F323	A:A:Y296	4.13	Yes	Yes	3	4	4
233	A:A:A300	A:A:F323	2.77	No	Yes	3	5	4
234	A:A:Q306	A:A:Y302	18.04	No	Yes	3	5	6
235	A:A:E308	A:A:Q304	10.19	No	No	3	3	5
236	A:A:Q304	A:A:T321	17.01	No	Yes	3	5	5
237	A:A:F323	A:A:Q304	4.68	Yes	No	3	4	5
238	A:A:E308	A:A:T321	7.06	No	Yes	3	3	5
239	A:A:K314	A:A:N311	5.6	No	Yes	0	3	8
240	A:A:K317	A:A:N311	6.99	Yes	Yes	13	7	8
241	A:A:I319	A:A:N311	5.66	No	Yes	0	5	8
242	A:A:R313	A:A:T316	3.88	No	No	0	4	3
243	A:A:K317	A:A:R313	3.71	Yes	No	0	7	4
244	A:A:D315	R:R:H232	5.04	No	No	0	3	4
245	A:A:E318	A:A:Y320	17.96	No	Yes	14	4	7
246	A:A:E318	A:A:K345	8.1	No	Yes	14	4	5
247	A:A:A338	A:A:Y320	8.01	No	Yes	0	6	7
248	A:A:D341	A:A:Y320	9.2	No	Yes	14	8	7
249	A:A:V342	A:A:Y320	5.05	No	Yes	14	7	7
250	A:A:K345	A:A:Y320	3.58	Yes	Yes	14	5	7
251	A:A:H322	A:A:K330	5.24	Yes	No	0	9	4
252	A:A:H322	A:A:N331	7.65	Yes	No	0	9	8
253	A:A:F334	A:A:H322	22.63	No	Yes	17	3	9
254	A:A:N331	A:A:T324	5.85	No	No	0	8	9
255	A:A:C325	A:A:K330	6.47	No	No	0	7	4
256	A:A:T327	A:A:T329	3.14	No	No	0	8	9
257	A:A:F336	A:A:Q333	4.68	Yes	Yes	7	8	5
258	A:A:D337	A:A:Q333	9.14	No	Yes	7	4	5
259	A:A:D337	A:A:F336	3.58	No	Yes	7	4	8
260	A:A:F336	A:A:T340	7.78	Yes	No	0	8	6
261	A:A:I343	A:A:V339	3.07	Yes	No	0	7	8
262	A:A:D341	A:A:K345	5.53	No	Yes	14	8	5
263	A:A:D341	R:R:K234	6.91	No	No	0	8	7
264	A:A:N346	A:A:V342	4.43	No	No	0	4	7
265	A:A:I343	A:A:N347	4.25	Yes	No	0	7	8
266	A:A:I343	R:R:T142	3.04	Yes	No	0	7	5
267	A:A:K345	R:R:Q233	4.07	Yes	No	0	5	5
268	A:A:N347	R:R:A137	4.69	No	No	0	8	8
269	A:A:L348	A:A:L353	4.15	Yes	No	0	9	7
270	A:A:L348	R:R:I138	5.71	Yes	No	0	9	8
271	A:A:L348	R:R:L226	2.77	Yes	Yes	0	9	8
272	A:A:L348	R:R:A237	4.73	Yes	No	0	9	7
273	A:A:F354	A:A:K349	4.96	Yes	No	0	5	5
274	A:A:D350	R:R:K308	5.53	No	No	0	4	6
275	A:A:C351	R:R:R134	4.18	No	Yes	0	4	9
276	A:A:L353	R:R:R134	9.72	No	Yes	0	7	9
277	A:A:L353	R:R:T241	5.9	No	Yes	0	7	7
278	A:A:F354	R:R:Q233	16.4	Yes	No	0	5	5
279	A:A:F354	R:R:K236	8.69	Yes	No	0	5	8
280	A:A:F354	R:R:A237	2.77	Yes	No	0	5	7
281	B:B:L7	G:G:A12	4.73	No	No	0	8	5
282	B:B:L7	G:G:V16	2.98	No	No	0	8	7
283	B:B:Q9	B:B:R8	5.84	No	No	0	3	3
284	B:B:E12	B:B:R8	17.45	No	No	0	4	3
285	B:B:Q13	B:B:Q9	5.12	No	No	0	1	3
286	B:B:E10	G:G:V16	5.7	No	No	0	8	7
287	B:B:L14	G:G:L19	5.54	Yes	Yes	0	8	9
288	B:B:L14	G:G:K20	4.23	Yes	No	0	8	6
289	B:B:K15	G:G:L19	2.82	No	Yes	0	6	9
290	B:B:Q17	G:G:A23	3.03	No	No	0	4	8
291	B:B:I18	B:B:R22	3.76	No	No	0	7	6
292	B:B:I18	G:G:A23	3.25	No	No	0	7	8
293	B:B:I18	G:G:R27	5.01	No	Yes	0	7	8
294	B:B:A21	G:G:R27	5.53	No	Yes	0	4	8
295	B:B:D258	B:B:R22	14.29	Yes	No	0	7	6
296	B:B:Q259	B:B:R22	9.35	No	No	0	6	6
297	B:B:A26	B:B:Q259	3.03	No	No	0	3	6
298	B:B:D27	G:G:K29	5.53	No	No	0	8	4
299	B:B:D27	G:G:S31	4.42	No	No	0	8	9
300	B:B:Q32	B:B:T29	11.34	No	No	0	1	3
301	B:B:L261	B:B:L30	5.54	No	No	0	5	5
302	B:B:L30	B:B:M262	7.07	No	Yes	0	5	4
303	B:B:L30	G:G:A34	4.73	No	No	0	5	6
304	B:B:I33	G:G:A34	3.25	No	No	0	3	6
305	B:B:I37	B:B:T34	3.04	Yes	No	9	2	5
306	B:B:K301	B:B:T34	4.5	Yes	No	9	5	5
307	B:B:T34	G:G:M38	3.01	No	Yes	9	5	4
308	B:B:I37	B:B:R283	5.01	Yes	Yes	9	2	9
309	B:B:I37	B:B:L300	4.28	Yes	Yes	9	2	6
310	B:B:I37	B:B:K301	4.36	Yes	Yes	9	2	5
311	B:B:I37	G:G:M38	4.37	Yes	Yes	9	2	4
312	B:B:I37	G:G:E42	4.1	Yes	No	9	2	1
313	B:B:K301	B:B:P39	11.71	Yes	No	0	5	1
314	B:B:I43	B:B:V40	3.07	Yes	Yes	0	3	3
315	B:B:R283	B:B:V40	9.15	Yes	Yes	9	9	3
316	B:B:D298	B:B:V40	7.3	No	Yes	9	9	3
317	B:B:V40	G:G:L51	2.98	Yes	Yes	9	3	6
318	B:B:Q44	B:B:R42	4.67	No	No	0	4	2
319	B:B:G306	B:B:R42	3	No	No	0	4	2
320	B:B:I43	B:B:M45	2.92	Yes	No	0	3	4
321	B:B:I43	B:B:L284	5.71	Yes	Yes	0	3	5
322	B:B:A305	B:B:I43	3.25	No	Yes	0	4	3
323	B:B:L308	B:B:M45	5.65	Yes	No	0	7	4
324	B:B:M45	G:G:L50	7.07	No	No	0	4	9
325	B:B:R46	B:B:R48	6.4	No	Yes	0	5	7
326	B:B:K337	B:B:T47	9.01	Yes	No	8	6	3
327	B:B:T47	B:B:W339	3.64	No	Yes	8	3	9
328	B:B:N340	B:B:R48	4.82	No	Yes	4	9	7
329	B:B:R48	G:G:N59	3.62	Yes	Yes	4	7	9
330	B:B:R48	G:G:F61	3.21	Yes	Yes	4	7	8
331	B:B:R49	B:B:T87	5.17	No	No	0	7	5
332	B:B:I338	B:B:R49	5.01	Yes	No	4	5	7
333	B:B:R49	G:G:F61	6.41	No	Yes	4	7	8
334	B:B:R52	B:B:T50	11.64	No	No	8	7	3
335	B:B:K337	B:B:T50	7.51	Yes	No	8	6	3
336	B:B:T50	R:R:K67	3	No	Yes	8	3	6
337	B:B:L51	B:B:L70	4.15	Yes	Yes	4	9	5
338	B:B:L51	B:B:W82	14.81	Yes	Yes	4	9	9
339	B:B:L51	B:B:T87	4.42	Yes	No	0	9	5
340	B:B:L336	B:B:L51	8.3	Yes	Yes	4	7	9
341	B:B:I338	B:B:L51	2.85	Yes	Yes	4	5	9
342	B:B:F335	B:B:R52	6.41	Yes	No	8	4	7
343	B:B:R52	R:R:K67	4.95	No	Yes	8	7	6
344	B:B:H54	B:B:I58	9.28	Yes	No	4	9	9
345	B:B:H54	B:B:S72	9.76	Yes	No	4	9	9
346	B:B:H54	B:B:S74	12.55	Yes	No	4	9	9
347	B:B:D76	B:B:H54	5.04	Yes	Yes	4	9	9
348	B:B:H54	B:B:I80	13.26	Yes	Yes	4	9	8
349	B:B:H54	B:B:W82	3.17	Yes	Yes	4	9	9
350	B:B:A56	B:B:D76	3.09	No	Yes	0	7	9
351	B:B:K57	B:B:Y59	7.17	No	Yes	2	9	8
352	B:B:K57	B:B:W332	24.37	No	Yes	2	9	9
353	B:B:I58	B:B:S74	3.1	No	No	4	9	9
354	B:B:I58	B:B:L336	2.85	No	Yes	4	9	7
355	B:B:Q75	B:B:Y59	16.91	No	Yes	2	9	8
356	B:B:W332	B:B:Y59	6.75	Yes	Yes	2	9	8
357	B:B:M61	B:B:W63	4.65	Yes	Yes	4	6	7
358	B:B:L70	B:B:M61	2.83	Yes	Yes	4	5	6
359	B:B:C317	B:B:M61	4.86	No	Yes	0	7	6
360	B:B:L336	B:B:M61	2.83	Yes	Yes	4	7	6
361	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
362	B:B:H62	B:B:R150	19.18	No	No	0	6	6
363	B:B:L70	B:B:W63	7.97	Yes	Yes	4	5	7
364	B:B:S84	B:B:W63	6.18	Yes	Yes	4	5	7
365	B:B:G319	B:B:W63	2.81	No	Yes	0	5	7
366	B:B:T321	B:B:W63	12.13	No	Yes	4	7	7
367	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
368	B:B:I338	B:B:W63	4.7	Yes	Yes	4	5	7
369	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
370	B:B:D322	B:B:T65	4.34	No	No	0	1	1
371	B:B:D66	B:B:R68	3.57	No	No	0	8	5
372	B:B:D66	B:B:L69	5.43	No	No	0	8	5
373	B:B:S67	B:B:T321	7.99	No	No	4	5	7
374	B:B:D323	B:B:S67	10.31	No	No	4	7	5
375	B:B:D83	B:B:R68	15.48	No	No	0	8	5
376	B:B:R68	B:B:Y85	23.66	No	No	0	5	4
377	B:B:D83	B:B:L69	4.07	No	No	0	8	5
378	B:B:L70	B:B:W82	5.69	Yes	Yes	4	5	9
379	B:B:L70	B:B:S84	3	Yes	Yes	4	5	5
380	B:B:L79	B:B:V71	4.47	Yes	Yes	10	7	8
381	B:B:I81	B:B:V71	4.61	Yes	Yes	10	7	8
382	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
383	B:B:V71	B:B:Y105	3.79	Yes	Yes	10	8	6
384	B:B:V112	B:B:V71	4.81	Yes	Yes	10	8	8
385	B:B:S72	B:B:W82	7.41	No	Yes	4	9	9
386	B:B:L336	B:B:S72	6.01	Yes	No	4	7	9
387	B:B:A73	B:B:V100	3.39	No	No	0	9	9
388	B:B:A73	B:B:C103	3.61	No	No	0	9	8
389	B:B:D76	B:B:S74	8.83	Yes	No	4	9	9
390	B:B:Q75	B:B:W99	4.38	No	Yes	2	9	9
391	B:B:D76	B:B:K78	8.3	Yes	No	0	9	8
392	B:B:I93	B:B:L79	4.28	Yes	Yes	0	7	7
393	B:B:L79	B:B:L95	6.92	Yes	No	0	7	8
394	B:B:L79	B:B:V112	2.98	Yes	Yes	10	7	8
395	B:B:I80	B:B:W82	16.44	Yes	Yes	4	8	9
396	B:B:I80	B:B:K89	4.36	Yes	Yes	4	8	9
397	B:B:I81	B:B:V90	3.07	Yes	No	10	7	5
398	B:B:H91	B:B:I81	9.28	No	Yes	10	5	7
399	B:B:I81	B:B:I93	2.94	Yes	Yes	0	7	7
400	B:B:I81	B:B:L126	2.85	Yes	No	10	7	5
401	B:B:K89	B:B:W82	11.6	Yes	Yes	4	9	9
402	B:B:L336	B:B:W82	3.42	Yes	Yes	4	7	9
403	B:B:D83	B:B:T86	7.23	No	No	0	8	6
404	B:B:I338	B:B:S84	3.1	Yes	Yes	4	5	5
405	B:B:S84	G:G:F61	5.28	Yes	Yes	4	5	8
406	B:B:Y85	G:G:P60	13.91	No	No	4	4	9
407	B:B:Y85	G:G:F61	7.22	No	Yes	4	4	8
408	B:B:N88	B:B:T86	8.77	Yes	No	0	7	6
409	B:B:H91	B:B:V90	6.92	No	No	10	5	5
410	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
411	B:B:I93	B:B:Y124	7.25	Yes	Yes	0	7	6
412	B:B:I93	B:B:V133	10.75	Yes	No	0	7	4
413	B:B:C114	B:B:L95	6.35	No	No	0	8	8
414	B:B:L95	B:B:Y124	5.86	No	Yes	0	8	6
415	B:B:R134	B:B:R96	5.33	No	No	0	3	6
416	B:B:R96	B:B:V135	6.54	No	No	0	6	4
417	B:B:S97	B:B:W99	4.94	No	Yes	2	8	9
418	B:B:D118	B:B:S97	8.83	No	No	0	9	8
419	B:B:S98	B:B:W99	7.41	No	Yes	0	8	9
420	B:B:L117	B:B:W99	5.69	Yes	Yes	2	9	9
421	B:B:C114	B:B:V100	5.12	No	No	0	8	9
422	B:B:G116	B:B:M101	3.49	No	No	0	9	9
423	B:B:L117	B:B:M101	2.83	Yes	No	0	9	9
424	B:B:M101	B:B:Y145	9.58	No	Yes	0	9	8
425	B:B:C148	B:B:T102	3.38	Yes	No	0	6	8
426	B:B:C149	B:B:T102	3.38	Yes	No	0	8	8
427	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
428	B:B:G109	B:B:Y105	7.24	No	Yes	0	5	6
429	B:B:V112	B:B:Y105	3.79	Yes	Yes	10	8	6
430	B:B:L126	B:B:Y105	4.69	No	Yes	10	5	6
431	B:B:A106	B:B:F151	8.32	No	Yes	0	6	9
432	B:B:F151	B:B:P107	4.33	Yes	No	0	9	6
433	B:B:N110	B:B:S108	10.43	Yes	No	2	4	6
434	B:B:D154	B:B:S108	10.31	No	No	2	6	6
435	B:B:N110	B:B:Y111	5.81	Yes	Yes	2	4	4
436	B:B:K127	B:B:N110	6.99	No	Yes	0	4	4
437	B:B:D154	B:B:N110	8.08	No	Yes	2	6	4
438	B:B:I123	B:B:Y111	3.63	Yes	Yes	2	6	4
439	B:B:N125	B:B:Y111	12.79	No	Yes	0	4	4
440	B:B:S136	B:B:Y111	5.09	No	Yes	2	4	4
441	B:B:D154	B:B:Y111	9.2	No	Yes	2	6	4
442	B:B:V112	B:B:Y124	3.79	Yes	Yes	0	8	6
443	B:B:L126	B:B:V112	7.45	No	Yes	10	5	8
444	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
445	B:B:C114	B:B:G115	3.92	No	No	0	8	9
446	B:B:D118	B:B:I120	4.2	No	No	0	9	6
447	B:B:G144	B:B:N119	3.39	No	No	0	8	9
448	B:B:E138	B:B:I120	4.1	No	No	0	6	6
449	B:B:C121	B:B:L139	4.76	Yes	Yes	0	8	9
450	B:B:C121	B:B:L146	3.17	Yes	No	2	8	7
451	B:B:C121	B:B:C149	3.64	Yes	Yes	2	8	8
452	B:B:C121	B:B:T159	3.38	Yes	Yes	2	8	9
453	B:B:S122	B:B:Y124	6.36	No	Yes	0	8	6
454	B:B:E138	B:B:S122	7.19	No	No	0	6	8
455	B:B:I123	B:B:S136	4.64	Yes	No	2	6	4
456	B:B:I123	B:B:L139	4.28	Yes	Yes	0	6	9
457	B:B:I123	B:B:I171	4.42	Yes	No	2	6	6
458	B:B:V135	B:B:Y124	7.57	No	Yes	0	4	6
459	B:B:N125	B:B:T128	4.39	No	No	0	4	3
460	B:B:E130	B:B:T128	5.64	No	No	0	3	3
461	B:B:E130	B:B:N132	15.77	No	No	0	3	3
462	B:B:E138	B:B:V135	4.28	No	No	0	6	4
463	B:B:G174	B:B:R137	3	No	No	0	4	5
464	B:B:L139	B:B:W169	18.22	Yes	Yes	0	9	8
465	B:B:H142	B:B:T159	6.85	Yes	Yes	2	9	9
466	B:B:H142	B:B:S161	13.95	Yes	No	2	9	9
467	B:B:D163	B:B:H142	7.56	Yes	Yes	2	9	9
468	B:B:A167	B:B:H142	2.93	No	Yes	2	4	9
469	B:B:H142	B:B:W169	6.35	Yes	Yes	2	9	8
470	B:B:D163	B:B:T143	5.78	Yes	No	0	9	5
471	B:B:D163	B:B:G144	3.35	Yes	No	0	9	8
472	B:B:S147	B:B:Y145	3.82	No	Yes	0	9	8
473	B:B:G162	B:B:Y145	8.69	No	Yes	2	9	8
474	B:B:D186	B:B:Y145	9.2	Yes	Yes	2	9	8
475	B:B:M188	B:B:Y145	8.38	No	Yes	2	8	8
476	B:B:C149	B:B:L146	3.17	Yes	No	2	8	7
477	B:B:L146	B:B:T159	5.9	No	Yes	2	7	9
478	B:B:S147	B:B:S160	4.89	No	Yes	0	9	6
479	B:B:C148	B:B:R150	2.79	Yes	No	0	6	6
480	B:B:C148	B:B:S160	3.44	Yes	Yes	5	6	6
481	B:B:C148	B:B:L190	3.17	Yes	Yes	5	6	5
482	B:B:C149	B:B:I157	3.27	Yes	Yes	2	8	7
483	B:B:C149	B:B:T159	3.38	Yes	Yes	2	8	9
484	B:B:F151	B:B:I157	7.54	Yes	Yes	2	9	7
485	B:B:F151	B:B:I171	3.77	Yes	No	2	9	6
486	B:B:L152	B:B:Q156	3.99	Yes	No	5	3	5
487	B:B:L152	B:B:V158	2.98	Yes	Yes	5	3	5
488	B:B:L152	B:B:L168	2.77	Yes	Yes	5	3	6
489	B:B:L152	B:B:L192	5.54	Yes	No	5	3	5
490	B:B:D153	B:B:Q156	9.14	No	No	0	5	5
491	B:B:D170	B:B:N155	8.08	No	No	19	9	3
492	B:B:E172	B:B:N155	6.57	No	No	19	6	3
493	B:B:L168	B:B:Q156	5.32	Yes	No	5	6	5
494	B:B:I157	B:B:W169	3.52	Yes	Yes	2	7	8
495	B:B:I157	B:B:I171	5.89	Yes	No	2	7	6
496	B:B:L190	B:B:V158	4.47	Yes	Yes	5	5	5
497	B:B:L192	B:B:V158	4.47	No	Yes	5	5	5
498	B:B:F199	B:B:V158	5.24	Yes	Yes	5	9	5
499	B:B:T159	B:B:W169	9.7	Yes	Yes	2	9	8
500	B:B:S160	B:B:V187	6.46	Yes	Yes	5	6	9
501	B:B:L190	B:B:S160	6.01	Yes	Yes	5	5	6
502	B:B:G162	B:B:S161	3.71	No	No	2	9	9
503	B:B:D163	B:B:S161	10.31	Yes	No	2	9	9
504	B:B:D186	B:B:G162	5.03	Yes	No	2	9	9
505	B:B:D163	B:B:T165	10.12	Yes	No	0	9	7
506	B:B:T165	B:B:T181	3.14	No	No	0	7	2
507	B:B:C166	B:B:F180	2.79	Yes	Yes	5	8	7
508	B:B:C166	B:B:V187	5.12	Yes	Yes	5	8	9
509	B:B:C166	B:B:F199	4.19	Yes	Yes	5	8	9
510	B:B:C166	B:B:S201	3.44	Yes	Yes	5	8	9
511	B:B:A167	B:B:W169	5.19	No	Yes	2	4	8
512	B:B:A167	B:B:Q176	6.06	No	Yes	2	4	4
513	B:B:L168	B:B:T177	4.42	Yes	No	5	6	4
514	B:B:L168	B:B:T178	4.42	Yes	No	5	6	4
515	B:B:L168	B:B:V213	2.98	Yes	No	0	6	4
516	B:B:Q176	B:B:W169	14.24	Yes	Yes	2	4	8
517	B:B:D170	B:B:E172	3.9	No	No	19	9	6
518	B:B:D170	B:B:T173	7.23	No	No	0	9	5
519	B:B:Q175	B:B:T173	2.83	No	No	0	4	5
520	B:B:Q176	B:B:T179	8.5	Yes	No	0	4	4
521	B:B:T177	B:B:T178	3.14	No	No	5	4	4
522	B:B:F180	B:B:T178	7.78	Yes	No	5	7	4
523	B:B:F180	B:B:F199	12.86	Yes	Yes	5	7	9
524	B:B:F180	B:B:W211	15.03	Yes	Yes	5	7	8
525	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
526	B:B:H183	B:B:V187	6.92	Yes	Yes	5	9	9
527	B:B:H183	B:B:S201	6.97	Yes	Yes	5	9	9
528	B:B:A203	B:B:H183	8.78	No	Yes	5	8	9
529	B:B:D205	B:B:H183	6.3	Yes	Yes	5	9	9
530	B:B:H183	B:B:K209	15.72	Yes	Yes	5	9	6
531	B:B:H183	B:B:W211	3.17	Yes	Yes	5	9	8
532	B:B:D205	B:B:T184	5.78	Yes	No	0	9	3
533	B:B:C204	B:B:D186	3.11	Yes	Yes	2	7	9
534	B:B:S201	B:B:V187	3.23	Yes	Yes	5	9	9
535	B:B:A203	B:B:V187	3.39	No	Yes	5	8	9
536	B:B:C204	B:B:M188	3.24	Yes	No	2	7	8
537	B:B:I232	B:B:S189	6.19	Yes	No	0	8	7
538	B:B:F199	B:B:L190	6.09	Yes	Yes	5	9	5
539	B:B:C233	B:B:S191	3.44	No	No	0	3	8
540	B:B:F234	B:B:S191	6.61	No	No	0	5	8
541	B:B:F199	B:B:L192	3.65	Yes	No	5	9	5
542	B:B:A193	B:B:D195	3.09	No	No	0	4	5
543	B:B:A193	B:B:F234	4.16	No	No	0	4	5
544	B:B:G238	B:B:P194	4.06	No	No	0	7	4
545	B:B:D195	B:B:R197	8.34	No	No	0	5	5
546	B:B:R197	B:B:R214	21.32	No	No	0	5	9
547	B:B:L198	B:B:L210	4.15	No	Yes	0	3	5
548	B:B:D212	B:B:L198	5.43	No	No	0	9	3
549	B:B:F199	B:B:W211	12.03	Yes	Yes	5	9	8
550	B:B:L210	B:B:V200	2.98	Yes	Yes	0	5	6
551	B:B:I232	B:B:V200	7.68	Yes	Yes	6	8	6
552	B:B:F234	B:B:V200	10.49	No	Yes	0	5	6
553	B:B:F241	B:B:V200	7.87	Yes	Yes	6	6	6
554	B:B:S201	B:B:W211	7.41	Yes	Yes	5	9	8
555	B:B:G202	B:B:I229	5.29	No	No	0	6	7
556	B:B:A203	B:B:D205	3.09	No	Yes	5	8	9
557	B:B:C204	B:B:D228	12.45	Yes	Yes	2	7	9
558	B:B:D205	B:B:S207	5.89	Yes	No	0	9	5
559	B:B:S207	B:B:T223	3.2	No	No	0	5	2
560	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
561	B:B:K209	B:B:W211	8.12	Yes	Yes	5	6	8
562	B:B:C218	B:B:K209	6.47	No	Yes	5	5	6
563	B:B:K209	B:B:T221	12.01	Yes	No	0	6	7
564	B:B:L210	B:B:R219	4.86	Yes	No	0	5	5
565	B:B:L210	B:B:Q220	6.65	Yes	Yes	0	5	7
566	B:B:L210	B:B:L255	5.54	Yes	No	0	5	6
567	B:B:C218	B:B:W211	7.84	No	Yes	5	5	8
568	B:B:D212	B:B:E215	9.09	No	No	0	9	3
569	B:B:D212	B:B:R219	9.53	No	No	0	9	5
570	B:B:E215	B:B:M217	6.77	No	No	0	3	3
571	B:B:M217	B:B:R219	4.96	No	No	0	3	5
572	B:B:C218	G:G:Q18	6.1	No	No	0	5	9
573	B:B:F222	B:B:Q220	7.03	No	Yes	6	8	7
574	B:B:D258	B:B:Q220	11.75	Yes	Yes	6	7	7
575	B:B:Q220	G:G:I25	4.12	Yes	No	6	7	2
576	B:B:T221	G:G:E22	8.47	No	No	0	7	9
577	B:B:F222	B:B:F241	12.86	No	Yes	6	8	6
578	B:B:F222	B:B:F253	10.72	No	Yes	6	8	6
579	B:B:H225	B:B:I229	7.95	Yes	No	6	9	7
580	B:B:H225	B:B:T243	8.21	Yes	Yes	6	9	8
581	B:B:H225	B:B:S245	12.55	Yes	No	6	9	9
582	B:B:D247	B:B:H225	7.56	Yes	Yes	6	9	9
583	B:B:H225	B:B:T249	4.11	Yes	Yes	6	9	6
584	B:B:H225	B:B:R251	11.28	Yes	Yes	6	9	8
585	B:B:D247	B:B:E226	10.39	Yes	No	0	9	3
586	B:B:E226	B:B:R251	4.65	No	Yes	0	3	8
587	B:B:D246	B:B:S227	5.89	Yes	No	0	9	6
588	B:B:D247	B:B:S227	2.94	Yes	No	0	9	6
589	B:B:D228	B:B:D246	5.32	Yes	Yes	2	9	9
590	B:B:I229	B:B:T243	6.08	No	Yes	6	7	8
591	B:B:D246	B:B:N230	13.46	Yes	No	2	9	9
592	B:B:A231	B:B:V276	5.09	No	No	0	5	6
593	B:B:F241	B:B:I232	5.02	Yes	Yes	6	6	8
594	B:B:I232	B:B:T243	4.56	Yes	Yes	6	8	8
595	B:B:F235	B:B:P236	11.56	Yes	Yes	11	6	7
596	B:B:F235	B:B:N237	6.04	Yes	No	11	6	5
597	B:B:A240	B:B:F235	2.77	No	Yes	0	6	6
598	B:B:F235	B:B:F278	9.65	Yes	Yes	11	6	7
599	B:B:F235	B:B:G282	4.52	Yes	No	11	6	9
600	B:B:F235	G:G:L37	10.96	Yes	No	0	6	7
601	B:B:F235	G:G:Y40	4.13	Yes	Yes	11	6	6
602	B:B:F235	G:G:C41	4.19	Yes	No	0	6	7
603	B:B:F278	B:B:P236	4.33	Yes	Yes	11	7	7
604	B:B:G282	B:B:P236	4.06	No	Yes	11	9	7
605	B:B:P236	G:G:Y40	6.95	Yes	Yes	11	7	6
606	B:B:N237	B:B:N239	8.17	No	No	0	5	2
607	B:B:N237	G:G:Y40	10.47	No	Yes	11	5	6
608	B:B:N239	B:B:R256	14.46	No	No	0	2	9
609	B:B:F241	B:B:F253	11.79	Yes	Yes	6	6	6
610	B:B:A242	B:B:F278	2.77	No	Yes	11	4	7
611	B:B:A242	B:B:L285	3.15	No	No	11	4	6
612	B:B:F253	B:B:T243	7.78	Yes	Yes	6	6	8
613	B:B:G244	B:B:I273	5.29	No	No	0	5	6
614	B:B:D247	B:B:S245	10.31	Yes	No	6	9	9
615	B:B:D247	B:B:T249	11.56	Yes	Yes	6	9	6
616	B:B:A248	B:B:I269	3.25	No	No	0	5	4
617	B:B:T249	B:B:T263	3.14	Yes	Yes	6	6	1
618	B:B:S265	B:B:T249	4.8	No	Yes	6	2	6
619	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
620	B:B:C250	B:B:I273	6.55	No	No	0	8	6
621	B:B:E260	B:B:R251	22.1	No	Yes	6	6	8
622	B:B:R251	B:B:T263	12.94	Yes	Yes	6	8	1
623	B:B:L252	B:B:Y264	5.86	No	Yes	0	7	5
624	B:B:E260	B:B:F253	5.83	No	Yes	6	6	6
625	B:B:A257	B:B:D254	4.63	No	No	0	7	9
626	B:B:D254	G:G:A33	6.18	No	No	0	9	7
627	B:B:R256	G:G:I28	7.52	No	Yes	0	9	4
628	B:B:R256	G:G:D36	7.15	No	No	0	9	5
629	B:B:D258	G:G:I25	2.8	Yes	No	6	7	2
630	B:B:D258	G:G:R27	16.68	Yes	Yes	6	7	8
631	B:B:Q259	G:G:V30	4.3	No	No	0	6	8
632	B:B:E260	B:B:T263	5.64	No	Yes	6	6	1
633	B:B:M262	B:B:Y264	10.78	Yes	Yes	0	4	5
634	B:B:A302	B:B:M262	3.22	No	Yes	0	2	4
635	B:B:S265	B:B:T263	3.2	No	Yes	6	2	1
636	B:B:L285	B:B:Y264	4.69	No	Yes	0	6	5
637	B:B:W297	B:B:Y264	6.75	Yes	Yes	0	8	5
638	B:B:H266	B:B:N268	3.83	No	No	0	4	4
639	B:B:H266	B:B:R304	3.39	No	No	0	4	5
640	B:B:I269	B:B:Y289	6.04	No	Yes	15	4	7
641	B:B:I269	B:B:N295	2.83	No	Yes	15	4	6
642	B:B:C271	B:B:D290	6.22	No	Yes	0	5	6
643	B:B:C271	B:B:D291	4.67	No	No	0	5	8
644	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
645	B:B:I273	B:B:Y289	12.09	No	Yes	0	6	7
646	B:B:S275	B:B:T274	4.8	No	No	0	8	8
647	B:B:D290	B:B:T274	2.89	Yes	No	0	6	8
648	B:B:L318	B:B:S275	6.01	Yes	No	0	6	8
649	B:B:S277	B:B:V320	4.85	No	No	0	5	7
650	B:B:F278	B:B:G282	4.52	Yes	No	11	7	9
651	B:B:F278	B:B:L285	10.96	Yes	No	11	7	6
652	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
653	B:B:L284	B:B:S279	6.01	Yes	No	0	5	9
654	B:B:S279	G:G:D48	7.36	No	Yes	0	9	9
655	B:B:S279	G:G:L50	3	No	No	0	9	9
656	B:B:G324	B:B:K280	3.49	No	No	0	9	1
657	B:B:K280	G:G:D48	4.15	No	Yes	0	1	9
658	B:B:S281	G:G:D48	10.31	No	Yes	9	9	9
659	B:B:S281	G:G:L51	3	No	Yes	9	9	6
660	B:B:D298	B:B:R283	14.29	No	Yes	9	9	9
661	B:B:L300	B:B:R283	12.15	Yes	Yes	9	6	9
662	B:B:R283	G:G:L51	7.29	Yes	Yes	9	9	6
663	B:B:L284	B:B:V296	5.96	Yes	Yes	0	5	5
664	B:B:L284	G:G:L51	4.15	Yes	Yes	0	5	6
665	B:B:L286	B:B:V296	4.47	No	Yes	0	7	5
666	B:B:L286	B:B:L318	4.15	No	Yes	8	7	6
667	B:B:L286	B:B:V327	2.98	No	Yes	8	7	6
668	B:B:A287	B:B:Y289	5.34	No	Yes	0	6	7
669	B:B:G288	B:B:V315	3.68	No	No	0	7	7
670	B:B:D291	B:B:Y289	8.05	No	Yes	0	8	7
671	B:B:N295	B:B:Y289	8.14	Yes	Yes	15	6	7
672	B:B:W297	B:B:Y289	7.72	Yes	Yes	15	8	7
673	B:B:D290	B:B:R314	23.82	Yes	No	0	6	8
674	B:B:D291	B:B:N293	5.39	No	No	0	8	5
675	B:B:A309	B:B:N293	6.25	No	No	0	3	5
676	B:B:C294	B:B:L308	9.52	No	Yes	0	5	7
677	B:B:C294	B:B:L318	3.17	No	Yes	0	5	6
678	B:B:N295	B:B:W297	4.52	Yes	Yes	15	6	8
679	B:B:N295	B:B:R304	8.44	Yes	No	15	6	5
680	B:B:N295	B:B:V307	5.91	Yes	No	0	6	3
681	B:B:G306	B:B:V296	3.68	No	Yes	0	4	5
682	B:B:L308	B:B:V296	4.47	Yes	Yes	0	7	5
683	B:B:R304	B:B:W297	11	No	Yes	15	5	8
684	B:B:D298	B:B:K301	8.3	No	Yes	9	9	5
685	B:B:L300	G:G:M38	2.83	Yes	Yes	9	6	4
686	B:B:L300	G:G:C41	7.94	Yes	No	0	6	7
687	B:B:L308	B:B:W339	17.08	Yes	Yes	0	7	9
688	B:B:G310	B:B:W339	2.81	No	Yes	0	5	9
689	B:B:H311	B:B:V315	5.54	Yes	No	0	9	7
690	B:B:H311	B:B:T329	8.21	Yes	No	0	9	8
691	B:B:G330	B:B:H311	3.18	No	Yes	0	5	9
692	B:B:H311	B:B:S331	16.74	Yes	No	8	9	9
693	B:B:D333	B:B:H311	10.08	Yes	Yes	8	9	9
694	B:B:H311	B:B:K337	11.79	Yes	Yes	8	9	6
695	B:B:D312	B:B:D333	3.99	No	Yes	0	5	9
696	B:B:D312	R:R:K67	2.77	No	Yes	0	5	6
697	B:B:D312	R:R:H315	8.82	No	No	0	5	4
698	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
699	B:B:R314	B:B:W332	22.99	No	Yes	2	8	9
700	B:B:C317	B:B:S316	3.44	No	No	0	7	9
701	B:B:S316	B:B:W332	6.18	No	Yes	0	9	9
702	B:B:L318	B:B:V327	2.98	Yes	Yes	8	6	6
703	B:B:L318	B:B:T329	2.95	Yes	No	0	6	8
704	B:B:V320	B:B:V327	3.21	No	Yes	0	7	6
705	B:B:D323	B:B:T321	8.67	No	No	4	7	7
706	B:B:D323	B:B:M325	9.7	No	No	0	7	5
707	B:B:G324	G:G:P49	4.06	No	No	0	9	7
708	B:B:M325	G:G:P49	6.71	No	No	0	5	7
709	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
710	B:B:V327	B:B:W339	3.68	Yes	Yes	8	6	9
711	B:B:T329	B:B:W339	9.7	No	Yes	0	8	9
712	B:B:D333	B:B:S331	8.83	Yes	No	8	9	9
713	B:B:D333	B:B:F335	10.75	Yes	Yes	8	9	4
714	B:B:F335	B:B:S334	6.61	Yes	No	0	4	4
715	B:B:F335	R:R:K67	6.2	Yes	Yes	8	4	6
716	B:B:K337	B:B:W339	6.96	Yes	Yes	8	6	9
717	B:B:I338	G:G:F61	6.28	Yes	Yes	4	5	8
718	B:B:N340	G:G:N59	10.9	No	Yes	4	9	9
719	B:B:N340	G:G:F61	4.83	No	Yes	4	9	8
720	G:G:L15	G:G:L19	2.77	No	Yes	18	2	9
721	G:G:E22	G:G:Q18	11.47	No	No	0	9	9
722	G:G:I25	G:G:R27	12.53	No	Yes	6	2	8
723	G:G:I28	G:G:K32	2.91	Yes	No	0	4	5
724	G:G:A33	G:G:I28	3.25	No	Yes	0	7	4
725	G:G:D36	G:G:K32	9.68	No	No	0	5	5
726	G:G:E42	G:G:M38	6.77	No	Yes	9	1	4
727	G:G:H44	G:G:Y40	17.42	No	Yes	0	6	6
728	G:G:A43	G:G:H44	2.93	No	No	0	4	6
729	G:G:E47	G:G:H44	6.15	No	No	0	3	6
730	G:G:D48	G:G:P49	4.83	Yes	No	0	9	7
731	G:G:D48	G:G:L51	9.5	Yes	Yes	9	9	6
732	G:G:P55	G:G:V54	3.53	No	No	0	5	6
733	G:G:N59	G:G:V54	2.96	Yes	No	0	9	6
734	G:G:E58	G:G:S57	4.31	No	No	0	5	6
735	G:G:N59	G:G:P60	4.89	Yes	No	4	9	9
736	G:G:F61	G:G:P60	2.89	Yes	No	4	8	9
737	R:R:F36	R:R:F40	4.29	No	Yes	0	4	5
738	R:R:F36	R:R:K282	9.93	No	No	0	4	2
739	R:R:L41	R:R:N37	5.49	Yes	No	0	6	3
740	R:R:I39	R:R:T43	3.04	No	No	0	5	4
741	R:R:F40	R:R:I44	16.33	Yes	No	0	5	5
742	R:R:F40	R:R:I286	5.02	Yes	No	0	5	6
743	R:R:L41	R:R:P42	3.28	Yes	No	0	6	5
744	R:R:L41	R:R:Y45	5.86	Yes	Yes	0	6	7
745	R:R:A98	R:R:P42	3.74	No	No	0	5	5
746	R:R:P42	R:R:V99	3.53	No	No	0	5	4
747	R:R:E288	R:R:Y45	4.49	No	Yes	1	5	7
748	R:R:F292	R:R:Y45	10.32	Yes	Yes	1	7	7
749	R:R:I48	R:R:L91	2.85	No	No	0	7	8
750	R:R:F293	R:R:I48	12.56	No	No	20	5	7
751	R:R:C296	R:R:I48	6.55	No	No	20	7	7
752	R:R:F49	R:R:V88	3.93	No	Yes	0	6	6
753	R:R:F49	R:R:P92	8.67	No	No	0	6	9
754	R:R:C296	R:R:T51	3.38	No	No	0	7	5
755	R:R:G52	R:R:V88	3.68	No	Yes	0	8	6
756	R:R:I53	R:R:V88	3.07	No	Yes	0	5	6
757	R:R:G55	R:R:V54	3.68	No	No	0	8	4
758	R:R:L58	R:R:V54	2.98	No	No	0	5	4
759	R:R:G55	R:R:P299	4.06	No	No	1	8	9
760	R:R:F304	R:R:G55	3.01	Yes	No	1	6	8
761	R:R:N56	R:R:S81	2.98	No	No	0	9	9
762	R:R:D84	R:R:N56	12.12	Yes	No	0	9	9
763	R:R:N56	R:R:P299	13.03	No	No	0	9	9
764	R:R:F304	R:R:L58	3.65	Yes	No	0	6	5
765	R:R:S81	R:R:V59	8.08	No	No	0	9	8
766	R:R:A303	R:R:V59	5.09	No	No	1	7	8
767	R:R:F309	R:R:V59	5.24	Yes	No	1	8	8
768	R:R:I60	R:R:S81	4.64	No	No	0	7	9
769	R:R:F309	R:R:V62	7.87	Yes	No	0	8	7
770	R:R:S312	R:R:V62	3.23	No	No	0	6	7
771	R:R:A313	R:R:V62	3.39	No	No	0	5	7
772	R:R:M63	R:R:R70	6.2	Yes	Yes	1	6	6
773	R:R:D74	R:R:M63	8.32	Yes	Yes	1	8	6
774	R:R:M63	R:R:R77	6.2	Yes	Yes	1	6	8
775	R:R:L78	R:R:M63	2.83	No	Yes	1	5	6
776	R:R:K68	R:R:Q66	5.42	No	Yes	0	6	4
777	R:R:Q66	R:R:R70	3.5	Yes	Yes	1	4	6
778	R:R:D74	R:R:Q66	6.53	Yes	Yes	1	8	4
779	R:R:Q66	R:R:S312	4.33	Yes	No	0	4	6
780	R:R:D74	R:R:R70	3.57	Yes	Yes	1	8	6
781	R:R:L78	R:R:R70	6.07	No	Yes	1	5	6
782	R:R:S71	R:R:T73	4.8	No	No	0	7	7
783	R:R:D74	R:R:S71	8.83	Yes	No	0	8	7
784	R:R:K75	R:R:M72	4.32	No	No	0	6	6
785	R:R:M72	R:R:R148	4.96	No	Yes	0	6	6
786	R:R:K149	R:R:M72	2.88	No	No	0	6	6
787	R:R:D74	R:R:R77	3.57	Yes	Yes	1	8	8
788	R:R:E153	R:R:K75	8.1	No	No	0	7	6
789	R:R:F129	R:R:Y76	8.25	Yes	Yes	1	5	7
790	R:R:I130	R:R:Y76	6.04	Yes	Yes	1	8	7
791	R:R:D133	R:R:Y76	10.34	No	Yes	0	8	7
792	R:R:L151	R:R:Y76	3.52	Yes	Yes	1	4	7
793	R:R:A152	R:R:Y76	4	No	Yes	0	3	7
794	R:R:V156	R:R:Y76	3.79	Yes	Yes	1	5	7
795	R:R:A303	R:R:R77	4.15	No	Yes	1	7	8
796	R:R:F309	R:R:R77	9.62	Yes	Yes	1	8	8
797	R:R:L78	W:W:?1	13.92	No	Yes	1	5	0
798	R:R:H79	R:R:I126	3.98	Yes	Yes	0	9	7
799	R:R:H79	R:R:V156	9.69	Yes	Yes	1	9	5
800	R:R:H79	R:R:Y157	7.62	Yes	No	1	9	7
801	R:R:H79	R:R:W161	7.41	Yes	Yes	1	9	9
802	R:R:H79	W:W:?1	20.69	Yes	Yes	1	9	0
803	R:R:D84	R:R:L80	4.07	Yes	Yes	1	9	9
804	R:R:I126	R:R:L80	5.71	Yes	Yes	0	7	9
805	R:R:L127	R:R:L80	5.54	No	Yes	1	8	9
806	R:R:L80	R:R:N298	8.24	Yes	Yes	1	9	9
807	R:R:L80	R:R:Y302	3.52	Yes	Yes	1	9	9
808	R:R:V82	W:W:?1	4.5	No	Yes	0	5	0
809	R:R:A83	R:R:S122	3.42	No	No	0	8	7
810	R:R:D84	R:R:S123	4.42	Yes	No	0	9	9
811	R:R:C295	R:R:D84	4.67	Yes	Yes	1	9	9
812	R:R:D84	R:R:N298	8.08	Yes	Yes	1	9	9
813	R:R:F87	R:R:L91	4.87	Yes	No	0	7	8
814	R:R:F87	R:R:Y116	6.19	Yes	Yes	1	7	6
815	R:R:F87	R:R:S119	9.25	Yes	No	0	7	8
816	R:R:F87	R:R:L120	4.87	Yes	Yes	1	7	7
817	R:R:F292	R:R:F87	13.93	Yes	Yes	1	7	7
818	R:R:F87	R:R:H294	6.79	Yes	Yes	1	7	9
819	R:R:C295	R:R:F87	6.98	Yes	Yes	1	9	7
820	R:R:C295	R:R:V88	3.42	Yes	Yes	0	9	6
821	R:R:T90	R:R:W94	6.06	No	No	1	6	7
822	R:R:I115	R:R:T90	3.04	No	No	0	5	6
823	R:R:T90	R:R:Y116	4.99	No	Yes	1	6	6
824	R:R:F93	R:R:W102	8.02	Yes	Yes	12	6	9
825	R:R:F104	R:R:F93	5.36	Yes	Yes	12	7	6
826	R:R:F93	R:R:L108	8.53	Yes	Yes	12	6	5
827	R:R:F93	R:R:V112	11.8	Yes	No	12	6	5
828	R:R:H113	R:R:W94	9.52	Yes	No	0	6	7
829	R:R:W94	R:R:Y116	5.79	No	Yes	1	7	6
830	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
831	R:R:D97	R:R:N101	5.39	No	No	0	5	4
832	R:R:D97	R:R:W102	3.35	No	Yes	0	5	9
833	R:R:N101	R:R:R183	13.26	No	No	0	4	3
834	R:R:I185	R:R:N101	5.66	No	No	0	3	4
835	R:R:F104	R:R:W102	20.04	Yes	Yes	12	7	9
836	R:R:L108	R:R:W102	4.56	Yes	Yes	12	5	9
837	R:R:C109	R:R:W102	9.14	No	Yes	12	9	9
838	R:R:C186	R:R:W102	14.37	No	Yes	12	9	9
839	R:R:F104	R:R:Y103	4.13	Yes	No	0	7	3
840	R:R:F104	R:R:L108	6.09	Yes	Yes	12	7	5
841	R:R:K110	R:R:N106	5.6	No	No	21	7	3
842	R:R:N106	R:R:N176	5.45	No	No	21	3	4
843	R:R:N106	R:R:V177	7.39	No	No	0	3	4
844	R:R:L108	R:R:V112	2.98	Yes	No	12	5	5
845	R:R:C109	R:R:H113	2.95	No	Yes	0	9	6
846	R:R:C109	R:R:C186	7.28	No	No	12	9	9
847	R:R:A175	R:R:K110	3.21	No	No	0	4	7
848	R:R:K110	R:R:N176	5.6	No	No	21	7	4
849	R:R:D171	R:R:H113	10.08	Yes	Yes	0	4	6
850	R:R:A175	R:R:H113	4.39	No	Yes	0	4	6
851	R:R:T168	R:R:V114	7.93	Yes	No	0	6	5
852	R:R:D171	R:R:V114	4.38	Yes	No	0	4	5
853	R:R:F172	R:R:V114	11.8	No	No	0	4	5
854	R:R:L120	R:R:Y116	4.69	Yes	Yes	1	7	6
855	R:R:F292	R:R:Y116	4.13	Yes	Yes	1	7	6
856	R:R:T117	R:R:T168	3.14	No	Yes	0	5	6
857	R:R:D171	R:R:T117	5.78	Yes	No	0	4	5
858	R:R:T168	R:R:V118	4.76	Yes	No	0	6	5
859	R:R:L120	R:R:Y121	4.69	Yes	Yes	1	7	7
860	R:R:H203	R:R:L120	3.86	Yes	Yes	1	4	7
861	R:R:L120	R:R:W252	4.56	Yes	Yes	1	7	9
862	R:R:L167	R:R:Y121	9.38	No	Yes	1	5	7
863	R:R:Q202	R:R:Y121	3.38	No	Yes	1	3	7
864	R:R:H203	R:R:Y121	8.71	Yes	Yes	1	4	7
865	R:R:V206	R:R:Y121	10.09	No	Yes	1	4	7
866	R:R:G207	R:R:Y121	2.9	No	Yes	1	5	7
867	R:R:S122	R:R:W161	8.65	No	Yes	0	7	9
868	R:R:H294	R:R:S123	5.58	Yes	No	0	9	9
869	R:R:P211	R:R:V124	5.3	Yes	No	0	9	7
870	R:R:V124	R:R:W252	3.68	No	Yes	0	7	9
871	R:R:L125	R:R:V160	4.47	No	Yes	0	5	7
872	R:R:L125	R:R:P211	3.28	No	Yes	0	5	9
873	R:R:I126	R:R:I130	2.94	Yes	Yes	0	7	8
874	R:R:I126	R:R:V160	4.61	Yes	Yes	0	7	7
875	R:R:L127	R:R:N298	6.87	No	Yes	1	8	9
876	R:R:L127	R:R:Y302	10.55	No	Yes	1	8	9
877	R:R:A128	R:R:V214	3.39	No	No	0	7	6
878	R:R:F129	R:R:L151	3.65	Yes	Yes	1	5	4
879	R:R:F129	R:R:V155	5.24	Yes	No	1	5	2
880	R:R:F129	R:R:V156	3.93	Yes	Yes	1	5	5
881	R:R:F129	R:R:V160	6.55	Yes	Yes	1	5	7
882	R:R:I130	R:R:R134	6.26	Yes	Yes	1	8	9
883	R:R:I130	R:R:Y302	6.04	Yes	Yes	1	8	9
884	R:R:I215	R:R:S131	7.74	No	No	0	7	9
885	R:R:C218	R:R:S131	5.16	No	No	0	6	9
886	R:R:S131	R:R:Y219	13.99	No	Yes	0	9	8
887	R:R:L132	R:R:L151	5.54	No	Yes	0	6	4
888	R:R:D133	R:R:R148	14.29	No	Yes	0	8	6
889	R:R:R134	R:R:Y219	10.29	Yes	Yes	1	9	8
890	R:R:L244	R:R:R134	3.64	Yes	Yes	1	7	9
891	R:R:R134	R:R:Y302	7.2	Yes	Yes	1	9	9
892	R:R:V139	R:R:Y135	12.62	No	Yes	22	7	8
893	R:R:H140	R:R:Y135	7.62	Yes	Yes	22	6	8
894	R:R:C218	R:R:Y135	4.03	No	Yes	0	6	8
895	R:R:I221	R:R:Y135	6.04	No	Yes	0	4	8
896	R:R:L136	R:R:S144	4.5	No	No	0	5	5
897	R:R:L136	R:R:R148	4.86	No	Yes	0	5	6
898	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
899	R:R:I138	R:R:I222	2.94	No	No	0	8	8
900	R:R:H140	R:R:V139	11.07	Yes	No	22	6	7
901	R:R:K225	R:R:V139	4.55	No	No	0	4	7
902	R:R:H140	R:R:N143	3.83	Yes	No	0	6	5
903	R:R:H140	R:R:S144	2.79	Yes	No	0	6	5
904	R:R:K154	R:R:L150	2.82	No	No	0	3	4
905	R:R:L151	R:R:V155	4.47	Yes	No	1	4	2
906	R:R:A152	R:R:E153	3.02	No	No	0	3	7
907	R:R:V156	R:R:Y157	6.31	Yes	No	1	5	7
908	R:R:V156	R:R:V160	3.21	Yes	Yes	1	5	7
909	R:R:Y157	W:W:?1	9.43	No	Yes	1	7	0
910	R:R:G159	R:R:P163	4.06	No	No	0	3	4
911	R:R:V160	R:R:W161	7.36	Yes	Yes	1	7	9
912	R:R:W161	W:W:?1	19.47	Yes	Yes	1	9	0
913	R:R:I162	R:R:P163	3.39	No	No	0	4	4
914	R:R:L165	R:R:T168	2.95	No	Yes	0	3	6
915	R:R:I169	R:R:L166	2.85	No	No	0	3	4
916	R:R:L167	R:R:Q202	3.99	No	No	1	5	3
917	R:R:L167	R:R:V206	4.47	No	No	1	5	4
918	R:R:I169	R:R:P170	3.39	No	No	0	3	8
919	R:R:F199	R:R:P170	5.78	Yes	No	0	5	8
920	R:R:D171	R:R:R188	5.96	Yes	No	0	4	5
921	R:R:F174	R:R:I173	8.79	Yes	No	0	4	3
922	R:R:F174	R:R:Y190	8.25	Yes	Yes	1	4	4
923	R:R:F174	R:R:P191	4.33	Yes	Yes	1	4	5
924	R:R:F174	R:R:W195	7.02	Yes	Yes	1	4	5
925	R:R:C186	R:R:V177	6.83	No	No	0	9	4
926	R:R:F189	R:R:S178	6.61	No	No	0	3	1
927	R:R:D181	R:R:D182	6.65	No	No	0	2	6
928	R:R:D187	R:R:F189	14.33	No	No	0	3	3
929	R:R:R188	R:R:Y190	14.4	No	Yes	1	5	4
930	R:R:F199	R:R:R188	4.28	Yes	No	1	5	5
931	R:R:P191	R:R:Y190	4.17	Yes	Yes	1	5	4
932	R:R:W195	R:R:Y190	2.89	Yes	Yes	1	5	4
933	R:R:V196	R:R:Y190	6.31	No	Yes	0	4	4
934	R:R:F199	R:R:Y190	11.35	Yes	Yes	1	5	4
935	R:R:N192	R:R:P191	3.26	No	Yes	1	1	5
936	R:R:P191	R:R:W195	8.11	Yes	Yes	1	5	5
937	R:R:L194	R:R:N192	4.12	No	No	0	2	1
938	R:R:N192	R:R:W195	6.78	No	Yes	1	1	5
939	R:R:F199	R:R:W195	7.02	Yes	Yes	1	5	5
940	R:R:Q200	R:R:V196	2.87	Yes	No	0	5	4
941	R:R:L266	R:R:V196	2.98	No	No	0	3	4
942	R:R:F201	R:R:V197	3.93	No	No	0	4	3
943	R:R:L266	R:R:V197	2.98	No	No	0	3	3
944	R:R:L267	R:R:V197	8.94	No	No	0	1	3
945	R:R:F199	R:R:Q202	3.51	Yes	No	1	5	3
946	R:R:I259	R:R:Q200	5.49	No	Yes	0	5	5
947	R:R:D262	R:R:Q200	6.53	No	Yes	0	5	5
948	R:R:Q200	R:R:S263	10.11	Yes	No	0	5	5
949	R:R:F201	R:R:S263	6.61	No	No	0	4	5
950	R:R:H203	R:R:Y255	3.27	Yes	Yes	1	4	7
951	R:R:H203	R:R:Y256	13.07	Yes	Yes	1	4	8
952	R:R:I204	R:R:Y256	3.63	Yes	Yes	0	5	8
953	R:R:I204	R:R:I259	5.89	Yes	No	0	5	5
954	R:R:I204	R:R:S260	4.64	Yes	No	0	5	5
955	R:R:I209	R:R:M205	4.37	No	No	0	4	4
956	R:R:G207	R:R:V206	3.68	No	No	1	5	4
957	R:R:G207	R:R:Y256	2.9	No	Yes	1	5	8
958	R:R:L208	R:R:L253	2.77	No	No	0	8	5
959	R:R:L208	R:R:Y256	12.89	No	Yes	0	8	8
960	R:R:I209	R:R:I213	2.94	No	No	0	4	3
961	R:R:L210	R:R:P211	3.28	No	Yes	0	6	9
962	R:R:F248	R:R:G212	3.01	Yes	No	1	9	6
963	R:R:F249	R:R:G212	3.01	No	No	1	4	6
964	R:R:F248	R:R:I215	7.54	Yes	No	0	9	7
965	R:R:C220	R:R:L216	3.17	No	No	0	3	4
966	R:R:F249	R:R:L216	10.96	No	No	0	4	4
967	R:R:T241	R:R:Y219	6.24	Yes	Yes	0	7	8
968	R:R:L244	R:R:Y219	4.69	Yes	Yes	1	7	8
969	R:R:I245	R:R:Y219	6.04	No	Yes	0	7	8
970	R:R:Y219	R:R:Y302	2.98	Yes	Yes	1	8	9
971	R:R:I222	R:R:L226	2.85	No	Yes	0	8	8
972	R:R:I222	R:R:T241	3.04	No	Yes	0	8	7
973	R:R:I223	R:R:L238	2.85	No	No	0	4	5
974	R:R:I223	R:R:T241	6.08	No	Yes	0	4	7
975	R:R:I223	R:R:V242	3.07	No	No	0	4	4
976	R:R:K225	R:R:S224	4.59	No	No	0	4	4
977	R:R:K234	R:R:L226	2.82	No	Yes	0	7	8
978	R:R:L226	R:R:L238	2.77	Yes	No	0	8	5
979	R:R:H228	R:R:S229	5.58	No	No	0	5	5
980	R:R:K234	R:R:S229	12.24	No	No	0	7	5
981	R:R:H232	R:R:R235	3.39	No	No	0	4	5
982	R:R:H232	R:R:K236	15.72	No	No	0	4	8
983	R:R:K236	R:R:K239	4.31	No	No	0	8	6
984	R:R:L246	R:R:V242	2.98	No	No	0	5	4
985	R:R:L244	R:R:L301	4.15	Yes	Yes	0	7	7
986	R:R:L244	R:R:Y302	5.86	Yes	Yes	1	7	9
987	R:R:F248	R:R:F249	10.72	Yes	No	1	9	4
988	R:R:F248	R:R:W252	7.02	Yes	Yes	1	9	9
989	R:R:C251	R:R:W252	3.92	No	Yes	0	8	9
990	R:R:W252	R:R:Y255	2.89	Yes	Yes	1	9	7
991	R:R:W252	R:R:Y256	9.65	Yes	Yes	1	9	8
992	R:R:A291	R:R:W252	5.19	No	Yes	1	8	9
993	R:R:H294	R:R:W252	15.87	Yes	Yes	1	9	9
994	R:R:P254	R:R:T287	5.25	No	No	0	9	6
995	R:R:Y255	R:R:Y256	5.96	Yes	Yes	1	7	8
996	R:R:I259	R:R:Y255	10.88	No	Yes	0	5	7
997	R:R:T287	R:R:Y255	3.75	No	Yes	0	6	7
998	R:R:E288	R:R:Y255	11.22	No	Yes	1	5	7
999	R:R:A291	R:R:Y255	4	No	Yes	1	8	7
1000	R:R:G258	R:R:I284	3.53	No	No	0	4	4
1001	R:R:I261	R:R:V280	6.14	No	No	0	5	5
1002	R:R:D262	R:R:H281	8.82	No	No	0	5	4
1003	R:R:D262	R:R:I284	4.2	No	No	0	5	4
1004	R:R:F264	R:R:I269	5.02	No	No	0	4	1
1005	R:R:I265	R:R:I270	2.94	No	No	0	3	5
1006	R:R:E277	R:R:I265	5.47	No	No	0	2	3
1007	R:R:I265	R:R:V280	4.61	No	No	0	3	5
1008	R:R:E268	R:R:K271	5.4	No	No	0	2	3
1009	R:R:F276	R:R:I270	3.77	Yes	No	0	1	5
1010	R:R:F276	R:R:Q272	8.2	Yes	No	0	1	2
1011	R:R:F276	R:R:V280	3.93	Yes	No	0	1	5
1012	R:R:K282	R:R:S285	3.06	No	No	0	2	5
1013	R:R:T287	R:R:W283	10.92	No	No	0	6	6
1014	R:R:E288	R:R:F292	10.49	No	Yes	1	5	7
1015	R:R:C296	R:R:F293	4.19	No	No	20	7	5
1016	R:R:C295	R:R:H294	7.37	Yes	Yes	1	9	9
1017	R:R:L297	R:R:L301	2.77	No	Yes	0	6	7
1018	R:R:N298	R:R:Y302	3.49	Yes	Yes	1	9	9
1019	R:R:F304	R:R:P299	2.89	Yes	No	1	6	9
1020	R:R:A303	R:R:F309	8.32	No	Yes	1	7	8
1021	R:R:F304	R:R:F309	5.36	Yes	Yes	1	6	8
1022	R:R:H315	R:R:T311	5.48	No	No	0	4	4
1023	G:G:E17	G:G:M21	2.71	No	No	0	6	1
1024	R:R:D193	R:R:L266	2.71	No	No	0	1	3
1025	A:A:E43	A:A:K270	2.7	Yes	Yes	0	9	9
1026	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
1027	R:R:A289	R:R:Y45	2.67	No	Yes	0	4	7
1028	B:B:L14	B:B:Q17	2.66	Yes	No	0	8	4
1029	A:A:E276	A:A:L273	2.65	No	Yes	0	5	6
1030	A:A:R208	A:A:S252	2.64	Yes	No	0	9	7
1031	B:B:E12	B:B:N16	2.63	No	No	0	4	1
1032	R:R:F276	R:R:T279	2.59	Yes	No	0	1	2
1033	R:R:F304	R:R:I300	2.51	Yes	No	0	6	6
1034	A:A:K29	A:A:R32	2.48	No	No	0	1	4
1035	A:A:F199	A:A:K197	2.48	Yes	No	0	5	6
1036	R:R:F40	R:R:L41	2.44	Yes	Yes	0	5	6
1037	B:B:F292	B:B:N313	2.42	No	No	0	4	7
1038	A:A:R15	B:B:H91	2.26	No	No	0	5	5
1039	R:R:E179	R:R:Y184	2.24	No	No	0	2	5
1040	A:A:G40	A:A:G45	2.11	No	No	0	9	9
1041	R:R:R183	R:R:Y184	2.06	No	No	0	3	5
1042	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
1043	A:A:A30	A:A:G27	1.95	No	No	0	3	5
1044	A:A:A41	A:A:G42	1.95	No	No	0	7	8
1045	A:A:A203	A:A:G183	1.95	No	No	0	9	9
1046	B:B:A140	B:B:G141	1.95	No	No	0	5	5
1047	B:B:A231	B:B:G244	1.95	No	No	0	5	5
1048	B:B:A193	B:B:P194	1.87	No	No	0	4	4
1049	R:R:A128	R:R:P211	1.87	No	Yes	0	7	9
1050	B:B:G77	B:B:S98	1.86	No	No	0	8	8
1051	B:B:G41	B:B:V40	1.84	No	Yes	0	1	3
1052	R:R:G159	R:R:V158	1.84	No	No	0	3	4
1053	B:B:G131	B:B:T128	1.82	No	No	0	4	3
1054	B:B:G185	B:B:T164	1.82	No	No	0	5	6
1055	B:B:G174	B:B:T173	1.82	No	No	0	4	5
1056	B:B:G182	B:B:T181	1.82	No	No	0	6	2
1057	B:B:G224	B:B:T223	1.82	No	No	0	6	2
1058	B:B:A60	B:B:C103	1.81	No	No	0	7	8
1059	R:R:G57	R:R:I60	1.76	No	No	0	3	7
1060	R:R:G258	R:R:I261	1.76	No	No	0	4	5
1061	B:B:P107	B:B:T65	1.75	No	No	0	6	1
1062	G:G:P53	G:G:T52	1.75	No	No	0	8	4
1063	B:B:G53	B:B:K89	1.74	No	Yes	0	9	9
1064	R:R:C218	R:R:S217	1.72	No	No	0	6	3
1065	A:A:G27	B:B:L55	1.71	No	No	0	5	6
1066	B:B:A28	G:G:S31	1.71	No	No	0	4	9
1067	B:B:G174	B:B:L139	1.71	No	Yes	0	4	9
1068	R:R:A100	R:R:V99	1.7	No	No	0	5	4
1069	A:A:C325	A:A:T327	1.69	No	No	0	7	8
1070	A:A:A203	A:A:T202	1.68	No	Yes	0	9	9
1071	B:B:G141	B:B:Q176	1.64	No	Yes	0	5	4
1072	R:R:L290	R:R:P254	1.64	No	No	0	7	9
1073	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
1074	A:A:N294	A:A:P282	1.63	No	No	0	3	5
1075	A:A:I343	R:R:A141	1.62	Yes	No	0	7	8
1076	A:A:I344	R:R:A141	1.62	No	No	0	6	8
1077	B:B:A28	B:B:I33	1.62	No	No	0	4	3
1078	R:R:A180	R:R:I185	1.62	No	No	0	1	3
1079	A:A:A245	A:A:M240	1.61	No	Yes	0	9	6
1080	A:A:K349	R:R:A307	1.61	No	No	0	5	5
1081	B:B:A26	B:B:K23	1.61	No	No	0	3	2
1082	B:B:D38	B:B:P39	1.61	No	No	0	1	1
1083	B:B:S31	B:B:T29	1.6	No	No	0	1	3
1084	A:A:T187	A:A:V50	1.59	No	No	0	6	6
1085	A:A:T187	A:A:V185	1.59	No	No	0	6	5
1086	B:B:A11	G:G:L15	1.58	No	No	18	5	2
1087	B:B:A11	G:G:L19	1.58	No	Yes	18	5	9
1088	R:R:A111	R:R:L108	1.58	No	Yes	0	4	5
1089	R:R:A247	R:R:L301	1.58	No	Yes	0	6	7
1090	G:G:E58	G:G:P55	1.57	No	No	0	5	5
1091	R:R:C274	R:R:N278	1.57	No	No	0	5	3
1092	A:A:A12	B:B:N88	1.56	No	Yes	0	4	7
1093	B:B:M262	B:B:S31	1.53	Yes	No	0	4	1
1094	R:R:I47	R:R:T51	1.52	No	No	0	4	5
1095	R:R:C274	R:R:E277	1.52	No	No	0	5	2
1096	A:A:A11	A:A:E8	1.51	No	No	0	4	5
1097	A:A:M198	A:A:T187	1.51	Yes	No	0	7	6
1098	A:A:A235	A:A:E236	1.51	No	No	0	4	9
1099	A:A:F354	A:A:G352	1.51	Yes	No	0	5	8
1100	A:A:F354	R:R:G306	1.51	Yes	No	0	5	8
1101	R:R:F104	R:R:G105	1.51	Yes	No	0	7	8
1102	R:R:F129	R:R:G159	1.51	Yes	No	0	5	3
1103	A:A:K51	A:A:T48	1.5	No	No	0	9	9
1104	B:B:T181	G:G:K14	1.5	No	No	0	2	4
1105	G:G:K46	G:G:T52	1.5	No	No	0	1	4
1106	R:R:G64	R:R:R70	1.5	No	Yes	0	2	6
1107	R:R:L86	R:R:S119	1.5	No	No	0	7	8
1108	R:R:L238	R:R:S227	1.5	No	No	0	5	4
1109	R:R:K239	R:R:T240	1.5	No	No	0	6	7
1110	B:B:L14	G:G:V16	1.49	Yes	No	0	8	7
1111	A:A:D9	A:A:S6	1.47	No	No	0	4	7
1112	R:R:I204	R:R:I209	1.47	Yes	No	0	5	4
1113	R:R:I257	R:R:I261	1.47	No	No	0	6	5
1114	R:R:I269	R:R:I270	1.47	No	No	0	1	5
1115	A:A:D9	A:A:V13	1.46	No	No	0	4	3
1116	A:A:D328	A:A:T327	1.45	No	No	0	9	8
1117	R:R:K308	R:R:K68	1.44	No	No	0	6	6
1118	R:R:P147	R:R:R146	1.44	No	No	0	4	5
1119	A:A:E238	A:A:V233	1.43	No	No	0	4	5
1120	R:R:I53	R:R:L85	1.43	No	No	0	5	7
1121	R:R:I89	R:R:L86	1.43	No	No	0	4	7
1122	R:R:I243	R:R:L301	1.43	No	Yes	0	5	7
1123	R:R:I300	R:R:L305	1.43	No	No	0	6	6
1124	G:G:D26	G:G:I28	1.4	No	Yes	0	1	4
1125	A:A:P288	A:A:Y287	1.39	No	Yes	0	5	7
1126	B:B:C25	G:G:R27	1.39	No	Yes	0	3	8
1127	A:A:D309	A:A:K314	1.38	No	No	0	4	3
1128	B:B:D303	B:B:K301	1.38	No	Yes	0	2	5
1129	A:A:D272	A:A:L273	1.36	No	Yes	0	9	6
1130	B:B:D76	B:B:L55	1.36	Yes	No	0	9	6
1131	A:A:E33	A:A:K29	1.35	No	No	0	6	1
1132	A:A:D193	R:R:N143	1.35	No	No	0	3	5
1133	B:B:D20	B:B:N16	1.35	No	No	0	2	1
1134	R:R:E153	R:R:K154	1.35	No	No	0	7	3
1135	R:R:A316	R:R:Y65	1.33	No	No	0	5	5
1136	R:R:A164	R:R:Y121	1.33	No	Yes	0	7	7
1137	A:A:H244	A:A:M240	1.31	Yes	Yes	0	4	6
1138	R:R:F199	R:R:V198	1.31	Yes	No	0	5	3
1139	A:A:D26	A:A:E25	1.3	No	No	0	5	4
1140	A:A:D237	A:A:E239	1.3	No	No	0	8	4
1141	G:G:E17	G:G:Q18	1.27	No	No	0	6	9
1142	R:R:D187	R:R:H113	1.26	No	Yes	0	3	6
1143	R:R:F49	R:R:L50	1.22	No	No	0	6	5
1144	B:B:L7	G:G:R13	1.21	No	No	0	8	6
1145	B:B:N16	B:B:R19	1.21	No	No	0	1	4
1146	A:A:E289	A:A:Y302	1.12	No	Yes	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:L23	3.9725	4	4	6
2	A:A:V34	6.2	5	7	5
3	A:A:L36	4.04	4	7	7
4	A:A:L37	5.792	5	0	9
5	A:A:E43	4.1825	4	0	9
6	A:A:I49	3.7225	4	7	7
7	A:A:F189	8.4225	4	0	9
8	A:A:F191	9.935	4	7	5
9	A:A:L194	5.9425	4	7	4
10	A:A:F196	7.635	6	7	7
11	A:A:M198	5.77	5	7	7
12	A:A:F199	7.10833	6	2	5
13	A:A:T202	5.5975	4	16	9
14	A:A:Q204	6.5175	4	2	9
15	A:A:S206	5.39	4	2	8
16	A:A:R208	4.06	5	2	9
17	A:A:K210	6.24143	7	2	9
18	A:A:W211	5.20875	8	2	9
19	A:A:I212	4.7625	4	2	8
20	A:A:H213	7.9425	4	2	8
21	A:A:C214	3.6375	4	2	7
22	A:A:F215	8.25	4	2	9
23	A:A:I221	4.405	4	2	8
24	A:A:I222	4.094	5	7	7
25	A:A:V225	5.6675	4	3	7
26	A:A:Y230	6.928	5	3	8
27	A:A:D231	6.57	5	3	9
28	A:A:M240	2.83	4	0	6
29	A:A:M243	3.428	5	3	8
30	A:A:H244	7.67	4	3	4
31	A:A:F250	7.662	5	0	9
32	A:A:N256	5.5125	4	2	8
33	A:A:W258	9.41833	6	2	5
34	A:A:F259	5.9575	4	2	9
35	A:A:I265	3.6725	4	0	8
36	A:A:F267	4.614	5	17	9
37	A:A:L268	5.416	5	3	8
38	A:A:K270	4.4675	4	3	9
39	A:A:L273	4.3125	4	3	6
40	A:A:F274	4.878	5	3	9
41	A:A:L283	6.6375	4	3	7
42	A:A:C286	8.295	4	3	6
43	A:A:Y287	9.14429	7	3	7
44	A:A:Y290	9.018	5	3	7
45	A:A:Y296	6.455	6	3	4
46	A:A:Y302	12.98	4	3	6
47	A:A:I303	4.6825	4	3	7
48	A:A:F307	7.095	6	3	8
49	A:A:N311	5.7425	4	13	8
50	A:A:K317	5.7475	4	13	7
51	A:A:Y320	8.14833	6	14	7
52	A:A:T321	9.335	4	3	5
53	A:A:H322	10.295	4	17	9
54	A:A:F323	4.7225	4	3	4
55	A:A:Q333	6.5675	4	7	5
56	A:A:F336	5.90857	7	7	8
57	A:A:I343	2.995	4	0	7
58	A:A:K345	5.32	4	14	5
59	A:A:L348	4.34	4	0	9
60	A:A:F354	5.97333	6	0	5
61	B:B:L14	3.48	4	0	8
62	B:B:I37	4.19333	6	9	2
63	B:B:V40	4.868	5	9	3
64	B:B:I43	3.7375	4	0	3
65	B:B:R48	4.5125	4	4	7
66	B:B:L51	6.906	5	4	9
67	B:B:H54	8.84333	6	4	9
68	B:B:Y59	8.984	5	2	8
69	B:B:M61	3.7925	4	4	6
70	B:B:W63	6.04714	7	4	7
71	B:B:L70	4.728	5	4	5
72	B:B:V71	4.22	5	10	8
73	B:B:D76	5.324	5	4	9
74	B:B:L79	4.6625	4	10	7
75	B:B:I80	9.585	4	4	8
76	B:B:I81	4.55	5	10	7
77	B:B:W82	8.93429	7	4	9
78	B:B:S84	4.39	4	4	5
79	B:B:N88	6.665	4	0	7
80	B:B:K89	5.59286	7	4	9
81	B:B:I93	5.722	5	0	7
82	B:B:W99	7.3825	8	2	9
83	B:B:Y105	4.52167	6	10	6
84	B:B:N110	7.8275	4	2	4
85	B:B:Y111	7.304	5	2	4
86	B:B:V112	4.564	5	10	8
87	B:B:L117	3.82	5	2	9
88	B:B:C121	3.7375	4	2	8
89	B:B:I123	4.2425	4	2	6
90	B:B:Y124	6.166	5	0	6
91	B:B:L139	7.2425	4	0	9
92	B:B:H142	7.528	5	2	9
93	B:B:Y145	7.17333	9	2	8
94	B:B:C148	3.195	4	5	6
95	B:B:C149	3.368	5	2	8
96	B:B:F151	5.14833	6	2	9
97	B:B:L152	3.82	4	5	3
98	B:B:I157	5.055	4	2	7
99	B:B:V158	4.29	4	5	5
100	B:B:T159	5.842	5	2	9
101	B:B:S160	5.2	4	5	6
102	B:B:D163	7.424	5	2	9
103	B:B:C166	3.885	4	5	8
104	B:B:L168	3.982	5	5	6
105	B:B:W169	9.53667	6	2	8
106	B:B:Q176	7.61	4	2	4
107	B:B:F180	8.294	5	5	7
108	B:B:H183	7.97667	6	5	9
109	B:B:D186	5.8075	4	2	9
110	B:B:V187	5.024	5	5	9
111	B:B:L190	4.935	4	5	5
112	B:B:F199	7.34333	6	5	9
113	B:B:V200	7.255	4	6	6
114	B:B:S201	5.2625	4	5	9
115	B:B:C204	5.122	5	2	7
116	B:B:D205	5.265	4	5	9
117	B:B:K209	10.58	4	5	6
118	B:B:L210	4.836	5	0	5
119	B:B:W211	8.93333	6	5	8
120	B:B:Q220	7.3875	4	6	7
121	B:B:H225	8.61	6	6	9
122	B:B:D228	7.555	4	2	9
123	B:B:I232	5.8625	4	6	8
124	B:B:F235	6.7275	8	11	6
125	B:B:P236	6.725	4	11	7
126	B:B:F241	8.062	5	6	6
127	B:B:T243	6.6575	4	6	8
128	B:B:D246	7.55	4	2	9
129	B:B:D247	8.552	5	6	9
130	B:B:T249	5.9025	4	6	6
131	B:B:R251	12.7425	4	6	8
132	B:B:F253	9.03	4	6	6
133	B:B:D258	11.38	4	6	7
134	B:B:M262	5.65	4	0	4
135	B:B:T263	6.23	4	6	1
136	B:B:Y264	6.422	5	0	5
137	B:B:F278	5.83333	6	11	7
138	B:B:R283	9.578	5	9	9
139	B:B:L284	5.4575	4	0	5
140	B:B:Y289	7.89667	6	15	7
141	B:B:D290	9.07	4	0	6
142	B:B:N295	5.968	5	15	6
143	B:B:V296	4.645	4	0	5
144	B:B:W297	7.4975	4	15	8
145	B:B:L300	6.8	4	9	6
146	B:B:K301	6.05	5	9	5
147	B:B:L308	9.18	4	0	7
148	B:B:H311	9.25667	6	8	9
149	B:B:L318	3.852	5	8	6
150	B:B:V327	3.2125	4	8	6
151	B:B:W332	11.0143	7	2	9
152	B:B:D333	8.4125	4	8	9
153	B:B:F335	7.4925	4	8	4
154	B:B:L336	4.682	5	4	7
155	B:B:K337	8.8175	4	8	6
156	B:B:I338	4.388	5	4	5
157	B:B:W339	7.31167	6	8	9
158	G:G:L19	3.1775	4	18	9
159	G:G:R27	8.228	5	6	8
160	G:G:I28	3.77	4	0	4
161	G:G:M38	4.245	4	9	4
162	G:G:Y40	9.7425	4	11	6
163	G:G:D48	7.23	5	9	9
164	G:G:L51	5.384	5	9	6
165	G:G:N59	5.5925	4	4	9
166	G:G:F61	5.035	8	4	8
167	R:R:F40	7.02	4	0	5
168	R:R:L41	4.2675	4	0	6
169	R:R:Y45	5.202	5	1	7
170	R:R:M63	5.8875	4	1	6
171	R:R:Q66	4.945	4	1	4
172	R:R:K67	4.23	4	8	6
173	R:R:R70	4.168	5	1	6
174	R:R:D74	6.164	5	1	8
175	R:R:Y76	5.99	6	1	7
176	R:R:R77	5.885	4	1	8
177	R:R:H79	9.878	5	1	9
178	R:R:L80	5.416	5	1	9
179	R:R:D84	6.672	5	1	9
180	R:R:F87	7.55429	7	1	7
181	R:R:V88	3.525	4	0	6
182	R:R:F93	8.4275	4	12	6
183	R:R:W102	9.91333	6	12	9
184	R:R:F104	7.28	6	12	7
185	R:R:L108	4.748	5	12	5
186	R:R:H113	5.64	5	0	6
187	R:R:Y116	5.158	5	1	6
188	R:R:L120	4.534	5	1	7
189	R:R:Y121	5.78286	7	1	7
190	R:R:I126	4.31	4	0	7
191	R:R:F129	4.855	6	1	5
192	R:R:I130	5.32	4	1	8
193	R:R:R134	6.88167	6	1	9
194	R:R:Y135	7.5775	4	22	8
195	R:R:H140	6.3275	4	22	6
196	R:R:R148	7.755	4	0	6
197	R:R:L151	4.295	4	1	4
198	R:R:V156	5.386	5	1	5
199	R:R:V160	5.24	5	1	7
200	R:R:W161	10.7225	4	1	9
201	R:R:T168	4.695	4	0	6
202	R:R:D171	6.55	4	0	4
203	R:R:F174	7.0975	4	1	4
204	R:R:Y190	7.895	6	1	4
205	R:R:P191	4.9675	4	1	5
206	R:R:W195	6.364	5	1	5
207	R:R:F199	5.54167	6	1	5
208	R:R:Q200	6.25	4	0	5
209	R:R:H203	7.2275	4	1	4
210	R:R:I204	3.9075	4	0	5
211	R:R:P211	3.4325	4	0	9
212	R:R:Y219	7.37167	6	1	8
213	R:R:L226	2.8025	4	0	8
214	R:R:T241	5.315	4	0	7
215	R:R:L244	4.585	4	1	7
216	R:R:F248	7.0725	4	1	9
217	R:R:W252	6.5975	8	1	9
218	R:R:Y255	5.99571	7	1	7
219	R:R:Y256	8.01667	6	1	8
220	R:R:F276	4.6225	4	0	1
221	R:R:F292	9.7175	4	1	7
222	R:R:H294	8.9025	4	1	9
223	R:R:C295	5.61	4	1	9
224	R:R:N298	6.67	4	1	9
225	R:R:L301	2.4825	4	0	7
226	R:R:Y302	5.66286	7	1	9
227	R:R:F304	3.484	5	1	6
228	R:R:F309	7.282	5	1	8
229	W:W:?1	13.602	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:C317	B:B:M61	24.1487	4.86	No	Yes	0	7	6
2	B:B:C317	B:B:S316	24.2539	3.44	No	No	0	7	9
3	B:B:S316	B:B:W332	24.3599	6.18	No	Yes	0	9	9
4	A:A:W258	B:B:W332	15.8497	3.75	Yes	Yes	2	5	9
5	A:A:N256	A:A:W258	27.8824	10.17	Yes	Yes	2	8	5
6	A:A:F259	A:A:N256	25.356	4.83	Yes	Yes	2	9	8
7	A:A:F259	A:A:I221	25.4896	8.79	Yes	Yes	2	9	8
8	A:A:I221	A:A:I264	29.9269	2.94	Yes	No	0	8	6
9	A:A:F250	A:A:I264	30.0192	3.77	Yes	No	0	9	6
10	A:A:F250	A:A:F307	65.5768	10.72	Yes	Yes	0	9	8
11	A:A:F307	A:A:M243	41.1718	3.73	Yes	Yes	3	8	8
12	A:A:I303	A:A:M243	49.8914	2.92	Yes	Yes	3	7	8
13	A:A:I303	A:A:L283	49.8346	4.28	Yes	Yes	3	7	7
14	A:A:L283	A:A:Y230	91.3688	5.86	Yes	Yes	3	7	8
15	A:A:K277	A:A:Y230	99.8359	7.17	No	Yes	3	9	8
16	A:A:K277	A:A:S228	100	3.06	No	No	3	9	9
17	A:A:K270	A:A:S228	99.7136	6.12	Yes	No	3	9	9
18	A:A:E43	A:A:K270	99.797	2.7	Yes	Yes	0	9	9
19	A:A:C224	A:A:E43	98.0179	4.56	No	Yes	0	7	9
20	A:A:C224	A:A:I49	96.5871	3.27	No	Yes	0	7	7
21	A:A:I49	A:A:M198	29.2521	2.92	Yes	Yes	7	7	7
22	A:A:L36	A:A:M198	19.028	4.24	Yes	Yes	7	7	7
23	A:A:L36	A:A:V34	18.5965	2.98	Yes	Yes	7	7	5
24	A:A:V339	A:A:V34	17.9851	8.02	No	Yes	7	8	5
25	A:A:I343	A:A:V339	44.7237	3.07	Yes	No	0	7	8
26	A:A:I343	A:A:N347	43.6966	4.25	Yes	No	0	7	8
27	A:A:N347	R:R:A137	43.3123	4.69	No	No	0	8	8
28	R:R:A137	R:R:R148	42.9281	6.91	No	Yes	0	8	6
29	A:A:F307	A:A:M247	41.6235	8.71	Yes	No	0	8	6
30	A:A:M247	A:A:Y287	41.6138	8.38	No	Yes	0	6	7
31	A:A:L283	A:A:Y287	41.7415	7.03	Yes	Yes	3	7	7
32	A:A:I222	A:A:I49	67.2413	4.42	Yes	Yes	7	7	7
33	A:A:I222	A:A:L36	18.9788	2.85	Yes	Yes	7	7	7
34	A:A:F196	A:A:L36	19.2419	6.09	Yes	Yes	7	7	7
35	A:A:F196	A:A:V339	27.1242	3.93	Yes	No	7	7	8
36	A:A:F189	A:A:M198	10.1125	7.46	Yes	Yes	0	9	7
37	A:A:I253	A:A:R208	17.4781	3.76	No	Yes	0	8	9
38	A:A:A41	A:A:L249	34.9922	3.15	No	No	0	7	9
39	A:A:L249	A:A:R208	52.3288	3.64	No	Yes	0	9	9
40	A:A:A41	A:A:S246	35.2034	3.42	No	No	0	7	9
41	B:B:G162	B:B:Y145	18.4129	8.69	No	Yes	2	9	8
42	B:B:G162	B:B:S161	18.1237	3.71	No	No	2	9	9
43	A:A:W211	B:B:Y145	71.3532	5.79	Yes	Yes	2	9	8
44	A:A:K210	B:B:Y145	32.5211	3.58	Yes	Yes	2	9	8
45	A:A:K210	B:B:D246	30.1579	5.53	Yes	Yes	2	9	9
46	A:A:I222	A:A:I265	48.3261	4.42	Yes	Yes	0	7	8
47	A:A:F223	A:A:L249	17.5076	7.31	No	No	0	9	9
48	A:A:F223	A:A:I253	17.5721	6.28	No	No	0	9	8
49	A:A:S246	A:A:V225	17.6933	4.85	No	Yes	3	9	7
50	A:A:A338	A:A:I265	48.4271	3.25	No	Yes	0	6	8
51	A:A:A338	A:A:Y320	48.3612	8.01	No	Yes	0	6	7
52	A:A:D341	A:A:Y320	46.8938	9.2	No	Yes	14	8	7
53	A:A:D341	R:R:K234	46.8601	6.91	No	No	0	8	7
54	R:R:K234	R:R:L226	46.6622	2.82	No	Yes	0	7	8
55	A:A:L348	R:R:L226	17.2353	2.77	Yes	Yes	0	9	8
56	A:A:L348	A:A:L353	17.2665	4.15	Yes	No	0	9	7
57	R:R:I222	R:R:L226	28.9597	2.85	No	Yes	0	8	8
58	R:R:L78	W:W:?1	17.7136	13.92	No	Yes	1	5	0
59	R:R:H79	R:R:V156	11.2075	9.69	Yes	Yes	1	9	5
60	R:R:V156	R:R:Y76	25.7025	3.79	Yes	Yes	1	5	7
61	R:R:D133	R:R:Y76	35.4147	10.34	No	Yes	0	8	7
62	R:R:D133	R:R:R148	35.7992	14.29	No	Yes	0	8	6
63	R:R:V156	R:R:Y157	10.009	6.31	Yes	No	1	5	7
64	A:A:L353	R:R:R134	17.1711	9.72	No	Yes	0	7	9
65	R:R:I222	R:R:T241	28.8201	3.04	No	Yes	0	8	7
66	B:B:D246	B:B:S227	29.8819	5.89	Yes	No	0	9	6
67	B:B:D247	B:B:S227	29.5855	2.94	Yes	No	0	9	6
68	B:B:D247	B:B:H225	26.8987	7.56	Yes	Yes	6	9	9
69	B:B:H225	B:B:T243	25.4122	8.21	Yes	Yes	6	9	8
70	B:B:F253	B:B:T243	17.9409	7.78	Yes	Yes	6	6	8
71	B:B:F222	B:B:F253	17.0547	10.72	No	Yes	6	8	6
72	B:B:F222	B:B:Q220	16.7625	7.03	No	Yes	6	8	7
73	B:B:D258	B:B:Q220	11.0946	11.75	Yes	Yes	6	7	7
74	B:B:I18	G:G:A23	11.698	3.25	No	No	0	7	8
75	B:B:Q17	G:G:A23	10.7985	3.03	No	No	0	4	8
76	B:B:D290	B:B:R314	12.4025	23.82	Yes	No	0	6	8
77	B:B:S147	B:B:Y145	23.74	3.82	No	Yes	0	9	8
78	B:B:S147	B:B:S160	23.4458	4.89	No	Yes	0	9	6
79	B:B:H142	B:B:S161	13.3501	13.95	Yes	No	2	9	9
80	B:B:H142	B:B:W169	10.3949	6.35	Yes	Yes	2	9	8
81	B:B:S160	B:B:V187	10.7468	6.46	Yes	Yes	5	6	9
82	R:R:R134	R:R:Y302	16.3449	7.2	Yes	Yes	1	9	9
83	R:R:L80	R:R:Y302	16.3601	3.52	Yes	Yes	1	9	9
84	R:R:D84	R:R:L80	16.4264	4.07	Yes	Yes	1	9	9
85	R:R:C295	R:R:D84	25.59	4.67	Yes	Yes	1	9	9
86	R:R:C295	R:R:F87	22.5788	6.98	Yes	Yes	1	9	7
87	R:R:T241	R:R:Y219	28.8518	6.24	Yes	Yes	0	7	8
88	R:R:Y219	R:R:Y302	16.3453	2.98	Yes	Yes	1	8	9
89	R:R:N298	R:R:Y302	16.3418	3.49	Yes	Yes	1	9	9
90	R:R:D84	R:R:N298	16.1898	8.08	Yes	Yes	1	9	9
91	R:R:S131	R:R:Y219	12.112	13.99	No	Yes	0	9	8
92	R:R:I215	R:R:S131	11.871	7.74	No	No	0	7	9
93	R:R:F248	R:R:I215	11.7882	7.54	Yes	No	0	9	7
94	R:R:F248	R:R:W252	11.3974	7.02	Yes	Yes	1	9	9
95	R:R:F87	R:R:Y116	13.8577	6.19	Yes	Yes	1	7	6
96	R:R:W94	R:R:Y116	16.1027	5.79	No	Yes	1	7	6
97	R:R:H113	R:R:W94	15.6932	9.52	Yes	No	0	6	7
98	A:A:F223	A:A:F250	35.1051	13.93	No	Yes	0	9	9
99	A:A:F307	A:A:S246	17.6165	3.96	Yes	No	3	8	9
100	A:A:R208	A:A:W211	68.866	4	Yes	Yes	2	9	9
101	A:A:W258	B:B:R314	11.7526	5	Yes	No	2	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M63	R:R:R70	6.2	1	Yes	Yes	6	6	2	2
R:R:L78	R:R:M63	2.83	1	No	Yes	5	6	1	2
R:R:L78	R:R:R70	6.07	1	No	Yes	5	6	1	2
R:R:L78	W:W:?1	13.92	1	No	Yes	5	0	1	0
R:R:H79	R:R:I126	3.98	1	Yes	Yes	9	7	1	2
R:R:H79	R:R:V156	9.69	1	Yes	Yes	9	5	1	2
R:R:H79	R:R:Y157	7.62	1	Yes	No	9	7	1	1
R:R:H79	R:R:W161	7.41	1	Yes	Yes	9	9	1	1
R:R:H79	W:W:?1	20.69	1	Yes	Yes	9	0	1	0
R:R:V82	W:W:?1	4.5	0	No	Yes	5	0	1	0
R:R:S122	R:R:W161	8.65	0	No	Yes	7	9	2	1
R:R:I126	R:R:V160	4.61	0	Yes	Yes	7	7	2	2
R:R:V156	R:R:Y157	6.31	1	Yes	No	5	7	2	1
R:R:V156	R:R:V160	3.21	1	Yes	Yes	5	7	2	2
R:R:Y157	W:W:?1	9.43	1	No	Yes	7	0	1	0
R:R:V160	R:R:W161	7.36	1	Yes	Yes	7	9	2	1
R:R:W161	W:W:?1	19.47	1	Yes	Yes	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
71.43	Single	8U4O	Cholesterol	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
62.50	Single	8U4Q	Cholesterol	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
57.14	Single	8U4P	Cholesterol	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
50.00	Single	8U4R	Cholesterol	8U4R-CXCR4-REGN7663-Fab-Cholesterol
37.50	Single	8T3O	2Y5	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22	Single	6KQI	Org27569	6KQI-CB₁-CP55940-Org27569
8.33	Single	5NDZ	AZ3451; Na	5NDZ-PAR2-AZ3451; Na
8.33	Single	8IKH	Q2L	8IKH-CB₁-Q2L-Gi1/β1/γ1
7.69	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
7.69	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/β1/γ2
7.14	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
6.25	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
5.88	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/β1/γ2

PDB Summary
PDB	8U4N
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR4
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Cholesterol
Protein Partners	Gi1/Beta1/Gamma2
PDB Resolution	2.72
Date	2024-03-13
D.O.I.	10.1101/2024.02.09.579708

Net Summary
I_min	2.77
Number of Linked Nodes	854
Number of Links	1146
Number of Hubs	229
Number of Links mediated by Hubs	798
Number of Communities	22
Number of Nodes involved in Communities	312
Number of Links involved in Communities	505

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	5048817
Length Of Smallest Path	3
Average Path Length	35.9838
Length of Longest Path	61
Minimum Path Strength	1.28
Average Path Strength	5.86603
Maximum Path Strength	23.7267
Minimum Path Correlation	0.7
Average Path Correlation	0.991969
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.32558
Average % Of Corr. Nodes	32.9037
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	62.9792
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • myosin binding • small molecule binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • bioluminescence • metabolic process • generation of precursor metabolites and energy • head development • central nervous system development • brain development • nervous system development • cell adhesion • regulation of cell adhesion • neuron recognition • cellular developmental process • cell development • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron development • cell recognition • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to ultrasound • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • forebrain development • telencephalon cell migration • forebrain cell migration • cell migration • telencephalon development • cell motility • apoptotic process • cell death • programmed cell death • epithelium development • endothelium development • tube development • morphogenesis of an endothelium • endothelial tube morphogenesis • morphogenesis of an epithelium • tissue development • tissue morphogenesis • anatomical structure morphogenesis • tube morphogenesis • epithelial tube morphogenesis • regulation of viral process • viral process • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • immune system process • mononuclear cell migration • leukocyte chemotaxis • detection of external stimulus • detection of stimulus involved in sensory perception of pain • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • epithelial cell development • epithelial cell differentiation • regulation of growth • developmental growth • cell projection organization • neuron projection development • regulation of cell morphogenesis • positive regulation of developmental process • cell projection morphogenesis • neuron projection morphogenesis • positive regulation of developmental growth • developmental growth involved in morphogenesis • positive regulation of dendrite extension • regulation of cellular component organization • regulation of developmental process • plasma membrane bounded cell projection morphogenesis • cell growth • cell morphogenesis • dendrite extension • positive regulation of cellular process • regulation of anatomical structure morphogenesis • neuron projection extension • regulation of developmental growth • plasma membrane bounded cell projection organization • developmental cell growth • growth • regulation of dendrite extension • positive regulation of cell growth • regulation of cell growth • positive regulation of growth • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • detection of mechanical stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • C-X-C chemokine receptor CXCR4 signaling pathway • response to activity • regulation of cell motility • positive regulation of mesenchymal stem cell migration • positive regulation of cell migration • regulation of mesenchymal stem cell migration • mesenchymal stem cell migration • positive regulation of cell motility • regulation of cell migration • calcium-mediated signaling • endothelial cell differentiation • angiogenesis • regulation of vasculature development • regulation of response to wounding • positive regulation of vascular wound healing • vascular wound healing • regulation of response to stress • regulation of multicellular organismal process • response to wounding • blood vessel development • positive regulation of response to wounding • wound healing • regulation of multicellular organismal development • blood vessel morphogenesis • angiogenesis involved in wound healing • positive regulation of angiogenesis • vasculature development • circulatory system development • positive regulation of vasculature development • positive regulation of wound healing • regulation of angiogenesis • regulation of wound healing • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • regulation of vascular wound healing • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • macrophage migration inhibitory factor signaling pathway • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of metabolic process • regulation of programmed cell death • response to tacrolimus • heart process • circulatory system process • cardiac muscle contraction • heart contraction • muscle contraction • muscle system process • blood circulation • striated muscle contraction • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • neuron migration • positive regulation of nervous system development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell surface • external side of plasma membrane • cell leading edge • anchoring junction • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • late endosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>8U4N_Chain_A S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K C T I V K Q M T G I V E T H F T F K D L H F K M F D V T A Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V L A E D E E M N R M H A S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C S T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8U4N_Chain_B Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8U4N_Chain_G A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8U4N_Chain_R F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V S L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8YU7 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	To be published
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	To be published
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/β1/γ2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol		3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/β1/γ2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol		3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol		2.72	2024-03-13	10.1101/2024.02.09.579708
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	Cholesterol	-	3.2	2025-02-26	To be published
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	Cholesterol	-	3.01	2025-02-26	To be published
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE8 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	10.1126/science.1194396
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	10.1126/science.1194396
	3ODU (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		2.5	2010-10-27	10.1126/science.1194396

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