psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I39	R:R:N35	4.25	No	No	0	5	3
2	R:R:F36	R:R:F40	8.57	No	No	0	4	5
3	R:R:L41	R:R:N37	5.49	Yes	No	0	6	3
4	R:R:F40	R:R:I44	5.02	No	No	0	5	5
5	R:R:L41	R:R:Y45	4.69	Yes	No	0	6	7
6	R:R:A98	R:R:P42	3.74	No	No	0	5	5
7	R:R:P42	R:R:V99	3.53	No	No	0	5	4
8	R:R:F292	R:R:Y45	6.19	Yes	No	0	7	7
9	R:R:F293	R:R:I48	15.07	Yes	No	0	5	7
10	R:R:F49	R:R:L50	3.65	Yes	No	0	6	5
11	R:R:F49	R:R:V88	3.93	Yes	No	0	6	6
12	R:R:F49	R:R:P92	7.22	Yes	No	0	6	9
13	R:R:C296	R:R:T51	5.07	No	No	0	7	5
14	R:R:I53	R:R:V88	3.07	No	No	0	5	6
15	R:R:G55	R:R:V54	3.68	No	No	0	8	4
16	R:R:G55	R:R:P299	4.06	No	No	0	8	9
17	R:R:N56	R:R:S81	5.96	Yes	No	0	9	9
18	R:R:D84	R:R:N56	6.73	No	Yes	0	9	9
19	R:R:N56	R:R:P299	6.52	Yes	No	0	9	9
20	R:R:S81	R:R:V59	6.46	No	No	0	9	8
21	R:R:I60	R:R:S81	6.19	No	No	0	7	9
22	R:R:F309	R:R:V62	7.87	Yes	No	0	8	7
23	R:R:A313	R:R:V62	3.39	No	No	0	5	7
24	R:R:D74	R:R:M63	8.32	Yes	No	0	8	6
25	R:R:D74	R:R:Q66	3.92	Yes	No	0	8	4
26	R:R:Q66	R:R:S312	4.33	No	No	0	4	6
27	R:R:D74	R:R:R70	4.76	Yes	No	0	8	6
28	R:R:D74	R:R:S71	4.42	Yes	No	0	8	7
29	R:R:K149	R:R:M72	4.32	No	No	0	6	6
30	R:R:R77	R:R:T73	3.88	No	No	0	8	7
31	R:R:D74	R:R:R77	3.57	Yes	No	0	8	8
32	R:R:E153	R:R:K75	13.5	No	No	0	7	6
33	R:R:I130	R:R:Y76	7.25	No	Yes	0	8	7
34	R:R:D133	R:R:Y76	11.49	No	Yes	0	8	7
35	R:R:V156	R:R:Y76	5.05	No	Yes	0	5	7
36	R:R:F309	R:R:R77	6.41	Yes	No	0	8	8
37	R:R:H79	R:R:I126	3.98	Yes	No	0	9	7
38	R:R:H79	R:R:V156	5.54	Yes	No	0	9	5
39	R:R:H79	R:R:W161	6.35	Yes	No	0	9	9
40	R:R:D84	R:R:L80	4.07	No	Yes	2	9	9
41	R:R:I126	R:R:L80	5.71	No	Yes	0	7	9
42	R:R:L127	R:R:L80	5.54	No	Yes	2	8	9
43	R:R:L80	R:R:N298	6.87	Yes	No	2	9	9
44	R:R:L80	R:R:Y302	3.52	Yes	Yes	2	9	9
45	R:R:A83	R:R:S122	3.42	No	No	0	8	7
46	R:R:D84	R:R:N298	8.08	No	No	2	9	9
47	R:R:I115	R:R:L86	4.28	No	No	0	5	7
48	R:R:F87	R:R:Y116	5.16	Yes	Yes	1	7	6
49	R:R:F87	R:R:S119	9.25	Yes	No	0	7	8
50	R:R:F87	R:R:L120	4.87	Yes	No	1	7	7
51	R:R:F292	R:R:F87	8.57	Yes	Yes	1	7	7
52	R:R:F87	R:R:H294	13.58	Yes	No	0	7	9
53	R:R:C295	R:R:F87	4.19	No	Yes	0	9	7
54	R:R:C295	R:R:V88	3.42	No	No	0	9	6
55	R:R:T90	R:R:V112	3.17	No	No	0	6	5
56	R:R:T90	R:R:Y116	3.75	No	Yes	0	6	6
57	R:R:F93	R:R:W102	4.01	Yes	Yes	3	6	9
58	R:R:F104	R:R:F93	4.29	Yes	Yes	3	7	6
59	R:R:F93	R:R:L108	4.87	Yes	No	3	6	5
60	R:R:F93	R:R:V112	7.87	Yes	No	0	6	5
61	R:R:V112	R:R:W94	4.9	No	No	0	5	7
62	R:R:H113	R:R:W94	6.35	Yes	No	0	6	7
63	L:L:?1	R:R:W94	17.46	Yes	No	0	0	7
64	R:R:F104	R:R:V96	5.24	Yes	No	0	7	5
65	R:R:D97	R:R:W102	5.58	No	Yes	0	5	9
66	R:R:N101	R:R:R183	10.85	No	No	0	4	3
67	R:R:F104	R:R:W102	6.01	Yes	Yes	3	7	9
68	R:R:C109	R:R:W102	6.53	No	Yes	3	9	9
69	R:R:C186	R:R:W102	10.45	No	Yes	3	9	9
70	R:R:F104	R:R:Y103	15.47	Yes	No	0	7	3
71	R:R:F104	R:R:L108	3.65	Yes	No	3	7	5
72	R:R:N106	R:R:V177	5.91	No	No	0	3	4
73	R:R:C109	R:R:H113	5.9	No	Yes	0	9	6
74	R:R:C109	R:R:C186	7.28	No	No	3	9	9
75	R:R:K110	R:R:N176	5.6	No	No	0	7	4
76	R:R:D171	R:R:H113	7.56	No	Yes	0	4	6
77	R:R:A175	R:R:H113	5.85	No	Yes	0	4	6
78	R:R:T168	R:R:V114	4.76	No	No	0	6	5
79	R:R:F172	R:R:V114	10.49	No	No	0	4	5
80	R:R:L120	R:R:Y116	4.69	No	Yes	1	7	6
81	R:R:F292	R:R:Y116	4.13	Yes	Yes	1	7	6
82	L:L:?1	R:R:Y116	5.67	Yes	Yes	1	0	6
83	R:R:T117	R:R:T168	3.14	No	No	0	5	6
84	R:R:D171	R:R:T117	8.67	No	No	0	4	5
85	R:R:L120	R:R:Y121	3.52	No	Yes	1	7	7
86	R:R:L167	R:R:Y121	9.38	No	Yes	1	5	7
87	R:R:Q202	R:R:Y121	4.51	Yes	Yes	1	3	7
88	R:R:H203	R:R:Y121	8.71	No	Yes	0	4	7
89	R:R:V206	R:R:Y121	3.79	No	Yes	1	4	7
90	R:R:S122	R:R:W161	7.41	No	No	0	7	9
91	R:R:H294	R:R:S123	5.58	No	No	0	9	9
92	R:R:P211	R:R:V124	5.3	No	No	0	9	7
93	R:R:V124	R:R:W252	3.68	No	Yes	0	7	9
94	R:R:L125	R:R:V160	4.47	No	Yes	0	5	7
95	R:R:I126	R:R:V160	4.61	No	Yes	0	7	7
96	R:R:L127	R:R:Y302	9.38	No	Yes	2	8	9
97	R:R:A128	R:R:V214	3.39	No	No	0	7	6
98	R:R:F129	R:R:V155	5.24	No	No	0	5	2
99	R:R:F129	R:R:V160	5.24	No	Yes	0	5	7
100	R:R:I130	R:R:R134	6.26	No	No	2	8	9
101	R:R:I130	R:R:Y302	6.04	No	Yes	2	8	9
102	R:R:I215	R:R:S131	6.19	No	No	0	7	9
103	R:R:C218	R:R:S131	5.16	No	No	0	6	9
104	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
105	R:R:C218	R:R:L132	3.17	No	No	0	6	6
106	R:R:D133	R:R:R148	13.1	No	Yes	0	8	6
107	R:R:R134	R:R:Y219	7.2	No	Yes	0	9	8
108	R:R:R134	R:R:Y302	6.17	No	Yes	2	9	9
109	R:R:V139	R:R:Y135	10.09	No	No	0	7	8
110	R:R:I221	R:R:Y135	6.04	No	No	0	4	8
111	R:R:L136	R:R:R148	3.64	No	Yes	0	5	6
112	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
113	R:R:H140	R:R:V139	5.54	No	No	0	6	7
114	R:R:K225	R:R:V139	4.55	No	No	0	4	7
115	R:R:H140	R:R:N143	7.65	No	No	0	6	5
116	R:R:L151	R:R:V155	5.96	No	No	0	4	2
117	R:R:G159	R:R:V158	3.68	No	No	0	3	4
118	R:R:G159	R:R:P163	4.06	No	No	0	3	4
119	R:R:V160	R:R:W161	8.58	Yes	No	0	7	9
120	R:R:I162	R:R:P163	3.39	No	No	0	4	4
121	R:R:L167	R:R:Q202	7.99	No	Yes	1	5	3
122	R:R:L167	R:R:V206	4.47	No	No	1	5	4
123	R:R:I169	R:R:P170	3.39	No	No	0	3	8
124	R:R:P170	R:R:R188	4.32	No	No	0	8	5
125	R:R:F199	R:R:P170	7.22	Yes	No	0	5	8
126	R:R:D171	R:R:R188	15.48	No	No	0	4	5
127	R:R:F174	R:R:I173	15.07	No	No	0	4	3
128	R:R:F174	R:R:Y190	6.19	No	Yes	1	4	4
129	R:R:F174	R:R:W195	6.01	No	Yes	1	4	5
130	R:R:C186	R:R:V177	3.42	No	No	0	9	4
131	R:R:I185	R:R:R183	7.52	No	No	0	3	3
132	R:R:D187	R:R:F189	9.55	No	No	0	3	3
133	R:R:R188	R:R:Y190	10.29	No	Yes	0	5	4
134	R:R:W195	R:R:Y190	3.86	Yes	Yes	1	5	4
135	R:R:V196	R:R:Y190	7.57	No	Yes	0	4	4
136	R:R:F199	R:R:Y190	14.44	Yes	Yes	1	5	4
137	R:R:N192	R:R:P191	3.26	No	No	0	1	5
138	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
139	R:R:D193	R:R:L266	9.5	No	No	0	1	3
140	R:R:F199	R:R:W195	6.01	Yes	Yes	1	5	5
141	R:R:F201	R:R:V197	3.93	No	No	0	4	3
142	R:R:L266	R:R:V197	4.47	No	No	0	3	3
143	R:R:F199	R:R:Q202	3.51	Yes	Yes	1	5	3
144	R:R:D262	R:R:Q200	5.22	No	No	0	5	5
145	R:R:F201	R:R:S263	5.28	No	No	0	4	5
146	R:R:Q202	R:R:V206	4.3	Yes	No	1	3	4
147	R:R:H203	R:R:Y256	8.71	No	Yes	0	4	8
148	R:R:L208	R:R:Y256	9.38	No	Yes	0	8	8
149	R:R:F248	R:R:I215	5.02	Yes	No	0	9	7
150	R:R:C220	R:R:L216	3.17	No	No	0	3	4
151	R:R:F249	R:R:L216	4.87	Yes	No	0	4	4
152	R:R:T241	R:R:Y219	3.75	No	Yes	0	7	8
153	R:R:L244	R:R:Y219	4.69	No	Yes	0	7	8
154	R:R:I245	R:R:Y219	4.84	No	Yes	0	7	8
155	R:R:I223	R:R:L238	4.28	No	No	0	4	5
156	R:R:I223	R:R:T241	6.08	No	No	0	4	7
157	R:R:K234	R:R:S229	12.24	No	No	0	7	5
158	R:R:H232	R:R:R235	4.51	No	No	0	4	5
159	R:R:H232	R:R:K236	14.41	No	No	0	4	8
160	R:R:L244	R:R:L301	5.54	No	Yes	0	7	7
161	R:R:F248	R:R:F249	7.5	Yes	Yes	4	9	4
162	R:R:F248	R:R:W252	6.01	Yes	Yes	0	9	9
163	R:R:F249	R:R:L253	4.87	Yes	No	0	4	5
164	R:R:W252	R:R:Y256	9.65	Yes	Yes	0	9	8
165	R:R:H294	R:R:W252	10.58	No	Yes	0	9	9
166	R:R:P254	R:R:T287	3.5	No	No	0	9	6
167	R:R:I259	R:R:Y255	6.04	No	No	0	5	7
168	R:R:E288	R:R:Y255	10.1	No	No	0	5	7
169	R:R:G258	R:R:I284	3.53	No	Yes	0	4	4
170	R:R:D262	R:R:I284	4.2	No	Yes	1	5	4
171	L:L:?1	R:R:D262	24.09	Yes	No	1	0	5
172	R:R:F264	R:R:I269	10.05	No	No	0	4	1
173	R:R:F264	R:R:I270	3.77	No	No	0	4	5
174	R:R:I265	R:R:V280	4.61	No	Yes	0	3	5
175	L:L:?1	R:R:L266	5.58	Yes	No	0	0	3
176	R:R:E268	R:R:K271	8.1	No	No	0	2	3
177	R:R:I270	R:R:Q272	4.12	No	No	0	5	2
178	R:R:F276	R:R:Q272	10.54	No	No	0	1	2
179	R:R:F276	R:R:V280	3.93	No	Yes	0	1	5
180	L:L:?1	R:R:E277	7.48	Yes	No	0	0	2
181	R:R:I284	R:R:V280	3.07	Yes	Yes	0	4	5
182	L:L:?1	R:R:H281	7.26	Yes	No	0	0	4
183	R:R:I286	R:R:K282	4.36	No	No	0	6	2
184	R:R:T287	R:R:W283	9.7	No	No	0	6	6
185	L:L:?1	R:R:I284	12.67	Yes	Yes	1	0	4
186	R:R:E288	R:R:F292	10.49	No	Yes	0	5	7
187	L:L:?1	R:R:E288	19.24	Yes	No	0	0	5
188	R:R:C296	R:R:F293	4.19	No	Yes	0	7	5
189	R:R:A303	R:R:F309	6.93	No	Yes	0	7	8
190	R:R:F304	R:R:F309	7.5	No	Yes	0	6	8
191	R:R:I47	R:R:T43	3.04	No	No	0	4	4
192	R:R:L136	R:R:S144	3	No	No	0	5	5
193	R:R:L267	R:R:V197	2.98	No	No	0	1	3
194	R:R:I44	R:R:I48	2.94	No	No	0	5	7
195	R:R:I138	R:R:I222	2.94	No	No	0	8	8
196	R:R:I204	R:R:I259	2.94	No	No	0	5	5
197	R:R:I209	R:R:I213	2.94	No	No	0	4	3
198	R:R:I209	R:R:M205	2.92	No	No	0	4	4
199	R:R:G207	R:R:Y256	2.9	No	Yes	0	5	8
200	R:R:I48	R:R:L91	2.85	No	No	0	7	8
201	R:R:I162	R:R:L166	2.85	No	No	0	4	4
202	R:R:L78	R:R:M63	2.83	No	No	0	5	6
203	R:R:G258	R:R:W283	2.81	No	No	0	4	6
204	R:R:K110	R:R:N106	2.8	No	No	0	7	3
205	R:R:H140	R:R:S144	2.79	No	No	0	6	5
206	R:R:H228	R:R:S227	2.79	No	No	0	5	4
207	R:R:H228	R:R:S229	2.79	No	No	0	5	5
208	R:R:H281	R:R:S285	2.79	No	No	0	4	5
209	R:R:L85	R:R:N56	2.75	No	Yes	0	7	9
210	R:R:H315	R:R:T311	2.74	No	No	0	4	4
211	R:R:K68	R:R:Q66	2.71	No	No	0	6	4
212	R:R:A95	R:R:Y45	2.67	No	No	0	7	7
213	R:R:A152	R:R:Y76	2.67	No	Yes	0	3	7
214	R:R:A291	R:R:Y255	2.67	No	No	0	8	7
215	R:R:D181	R:R:D182	2.66	No	No	0	2	6
216	R:R:F189	R:R:S178	2.64	No	No	0	3	1
217	R:R:C251	R:R:W252	2.61	No	Yes	0	8	9
218	R:R:F276	R:R:T279	2.59	No	No	0	1	2
219	R:R:F36	R:R:I286	2.51	No	No	0	4	6
220	R:R:F304	R:R:I300	2.51	No	No	0	6	6
221	R:R:M72	R:R:R148	2.48	No	Yes	0	6	6
222	R:R:F49	R:R:L91	2.44	Yes	No	0	6	8
223	R:R:F304	R:R:L58	2.44	No	No	0	6	5
224	R:R:F292	R:R:L91	2.44	Yes	No	0	7	8
225	R:R:F293	R:R:L297	2.44	Yes	No	0	5	6
226	R:R:I222	R:R:Y219	2.42	No	Yes	0	8	8
227	R:R:E179	R:R:Y184	2.24	No	No	0	2	5
228	R:R:C296	R:R:G52	1.96	No	No	0	7	8
229	R:R:A128	R:R:P211	1.87	No	No	0	7	9
230	R:R:G258	R:R:I257	1.76	No	No	0	4	6
231	R:R:G64	R:R:M63	1.75	No	No	0	2	6
232	R:R:G306	R:R:L305	1.71	No	No	0	8	6
233	R:R:A303	R:R:V59	1.7	No	No	0	7	8
234	R:R:A141	R:R:T142	1.68	No	No	0	8	5
235	R:R:L41	R:R:P42	1.64	Yes	No	0	6	5
236	R:R:L125	R:R:P163	1.64	No	No	0	5	4
237	R:R:L210	R:R:P211	1.64	No	No	0	6	9
238	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
239	R:R:A180	R:R:I185	1.62	No	No	0	1	3
240	R:R:A34	R:R:K38	1.61	No	No	0	1	4
241	R:R:V114	R:R:V118	1.6	No	No	0	5	5
242	R:R:A289	R:R:L41	1.58	No	Yes	0	4	6
243	R:R:A237	R:R:L226	1.58	No	No	0	7	8
244	R:R:A247	R:R:L301	1.58	No	Yes	0	6	7
245	R:R:C274	R:R:N278	1.57	No	No	0	5	3
246	R:R:I47	R:R:S46	1.55	No	No	0	4	5
247	R:R:I204	R:R:S260	1.55	No	No	0	5	5
248	R:R:I221	R:R:S217	1.55	No	No	0	4	3
249	R:R:I261	R:R:V280	1.54	No	Yes	0	5	5
250	R:R:K225	R:R:S224	1.53	No	No	0	4	4
251	R:R:I47	R:R:T51	1.52	No	No	0	4	5
252	R:R:I115	R:R:T90	1.52	No	No	0	5	6
253	R:R:A152	R:R:E153	1.51	No	No	0	3	7
254	R:R:F248	R:R:G212	1.51	Yes	No	4	9	6
255	R:R:F249	R:R:G212	1.51	Yes	No	4	4	6
256	R:R:L86	R:R:V82	1.49	No	No	0	7	5
257	R:R:L165	R:R:V118	1.49	No	No	0	3	5
258	R:R:L194	R:R:V198	1.49	No	No	0	2	3
259	R:R:I204	R:R:I209	1.47	No	No	0	5	4
260	R:R:L305	R:R:T240	1.47	No	No	0	6	7
261	R:R:N143	R:R:T142	1.46	No	No	0	5	5
262	R:R:I243	R:R:K239	1.45	No	No	0	5	6
263	R:R:P147	R:R:R146	1.44	No	No	0	4	5
264	R:R:I138	R:R:L226	1.43	No	No	0	8	8
265	R:R:I243	R:R:L301	1.43	No	Yes	0	5	7
266	R:R:K154	R:R:L150	1.41	No	No	0	3	4
267	R:R:L301	R:R:L305	1.38	Yes	No	0	7	6
268	R:R:L194	R:R:N192	1.37	No	No	0	2	1
269	R:R:D97	R:R:N101	1.35	No	No	0	5	4
270	R:R:A100	R:R:Y103	1.33	No	No	0	5	3
271	R:R:A164	R:R:Y121	1.33	No	Yes	0	7	7
272	R:R:F40	R:R:I39	1.26	No	No	0	5	5
273	R:R:D187	R:R:H113	1.26	No	Yes	0	3	6
274	R:R:V177	R:R:Y184	1.26	No	No	0	4	5
275	R:R:F293	R:R:L290	1.22	Yes	No	0	5	7
276	R:R:H79	R:R:Y157	1.09	Yes	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L41	3.35	4	0	6
2	R:R:F49	4.31	4	0	6
3	R:R:N56	5.49	4	0	9
4	R:R:D74	4.998	5	0	8
5	R:R:Y76	6.615	4	0	7
6	R:R:H79	4.24	4	0	9
7	R:R:L80	5.142	5	2	9
8	R:R:F87	7.60333	6	1	7
9	R:R:F93	5.26	4	3	6
10	R:R:W102	6.516	5	3	9
11	R:R:F104	6.932	5	3	7
12	R:R:H113	5.384	5	0	6
13	R:R:Y116	4.68	5	1	6
14	R:R:Y121	5.20667	6	1	7
15	R:R:R148	6.5325	4	0	6
16	R:R:V160	5.725	4	0	7
17	R:R:Y190	8.47	5	1	4
18	R:R:W195	5.3825	4	1	5
19	R:R:F199	7.795	4	1	5
20	R:R:Q202	5.0775	4	1	3
21	R:R:Y219	4.665	6	0	8
22	R:R:F248	5.01	4	4	9
23	R:R:F249	4.6875	4	4	4
24	R:R:W252	6.506	5	0	9
25	R:R:Y256	7.66	4	0	8
26	R:R:V280	3.2875	4	0	5
27	R:R:I284	5.8675	4	1	4
28	R:R:F292	6.364	5	1	7
29	R:R:F293	5.73	4	0	5
30	R:R:L301	2.4825	4	0	7
31	R:R:Y302	6.2775	4	2	9
32	R:R:F309	7.1775	4	0	8
33	L:L:?1	12.4312	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:I44	11.6714	5.02	No	No	0	5	5
2	R:R:I44	R:R:I48	13.6045	2.94	No	No	0	5	7
3	R:R:I48	R:R:L91	32.2642	2.85	No	No	0	7	8
4	R:R:F292	R:R:L91	39.2036	2.44	Yes	No	0	7	8
5	R:R:F292	R:R:Y45	15.751	6.19	Yes	No	0	7	7
6	R:R:L41	R:R:Y45	11.8849	4.69	Yes	No	0	6	7
7	R:R:F293	R:R:I48	17.6108	15.07	Yes	No	0	5	7
8	R:R:C296	R:R:F293	11.8483	4.19	No	Yes	0	7	5
9	R:R:D84	R:R:N56	36.3071	6.73	No	Yes	0	9	9
10	R:R:D84	R:R:L80	37.3864	4.07	No	Yes	2	9	9
11	R:R:L80	R:R:Y302	57.7535	3.52	Yes	Yes	2	9	9
12	R:R:R134	R:R:Y302	55.6253	6.17	No	Yes	2	9	9
13	R:R:R134	R:R:Y219	87.3956	7.2	No	Yes	0	9	8
14	R:R:S131	R:R:Y219	96.4571	5.09	No	Yes	0	9	8
15	R:R:I215	R:R:S131	97.6828	6.19	No	No	0	7	9
16	R:R:F248	R:R:I215	98.067	5.02	Yes	No	0	9	7
17	R:R:F248	R:R:W252	100	6.01	Yes	Yes	0	9	9
18	R:R:H294	R:R:W252	86.8894	10.58	No	Yes	0	9	9
19	R:R:F87	R:R:H294	87.2187	13.58	Yes	No	0	7	9
20	R:R:F292	R:R:F87	33.4533	8.57	Yes	Yes	1	7	7
21	R:R:N56	R:R:S81	29.9043	5.96	Yes	No	0	9	9
22	R:R:S81	R:R:V59	27.2334	6.46	No	No	0	9	8
23	R:R:A303	R:R:F309	24.4954	6.93	No	Yes	0	7	8
24	R:R:A303	R:R:V59	25.8613	1.7	No	No	0	7	8
25	R:R:D74	R:R:R77	13.3911	3.57	Yes	No	0	8	8
26	R:R:F309	R:R:R77	16.251	6.41	Yes	No	0	8	8
27	R:R:I130	R:R:R134	31.1238	6.26	No	No	2	8	9
28	R:R:I130	R:R:Y76	34.0996	7.25	No	Yes	0	8	7
29	R:R:D133	R:R:Y76	25.5442	11.49	No	Yes	0	8	7
30	R:R:D133	R:R:R148	24.1478	13.1	No	Yes	0	8	6
31	R:R:V156	R:R:Y76	10.0616	5.05	No	Yes	0	5	7
32	R:R:I126	R:R:L80	25.154	5.71	No	Yes	0	7	9
33	R:R:I126	R:R:V160	18.6414	4.61	No	Yes	0	7	7
34	R:R:T90	R:R:Y116	25.2515	3.75	No	Yes	0	6	6
35	R:R:F292	R:R:Y116	18.4401	4.13	Yes	Yes	1	7	6
36	R:R:L120	R:R:Y116	10.5189	4.69	No	Yes	1	7	6
37	R:R:T90	R:R:V112	20.794	3.17	No	No	0	6	5
38	R:R:F93	R:R:V112	22.3855	7.87	Yes	No	0	6	5
39	R:R:F93	R:R:W102	15.1168	4.01	Yes	Yes	3	6	9
40	L:L:?1	R:R:Y116	50.5397	5.67	Yes	Yes	1	0	6
41	L:L:?1	R:R:W94	35.8071	17.46	Yes	No	0	0	7
42	R:R:E288	R:R:F292	19.3487	10.49	No	Yes	0	5	7
43	L:L:?1	R:R:E288	14.4155	19.24	Yes	No	0	0	5
44	R:R:H113	R:R:W94	32.9715	6.35	Yes	No	0	6	7
45	R:R:C109	R:R:H113	16.2937	5.9	No	Yes	0	9	6
46	R:R:C109	R:R:C186	11.2629	7.28	No	No	3	9	9
47	R:R:C186	R:R:V177	16.312	3.42	No	No	0	9	4
48	R:R:D171	R:R:H113	17.1718	7.56	No	Yes	0	4	6
49	R:R:D171	R:R:T117	10.4275	8.67	No	No	0	4	5
50	R:R:L120	R:R:Y121	15.507	3.52	No	Yes	1	7	7
51	R:R:Q202	R:R:Y121	22.0196	4.51	Yes	Yes	1	3	7
52	R:R:H203	R:R:Y121	17.2937	8.71	No	Yes	0	4	7
53	R:R:L136	R:R:R148	18.3914	3.64	No	Yes	0	5	6
54	R:R:L136	R:R:S144	16.9218	3	No	No	0	5	5
55	R:R:H140	R:R:S144	15.44	2.79	No	No	0	6	5
56	R:R:F199	R:R:Q202	21.5928	3.51	Yes	Yes	1	5	3
57	R:R:F199	R:R:W195	10.1714	6.01	Yes	Yes	1	5	5
58	L:L:?1	R:R:L266	10.0555	5.58	Yes	No	0	0	3
59	R:R:W252	R:R:Y256	19.2085	9.65	Yes	Yes	0	9	8
60	R:R:L244	R:R:Y219	12.269	4.69	No	Yes	0	7	8
61	R:R:L244	R:R:L301	10.8055	5.54	No	Yes	0	7	7
62	L:L:?1	R:R:I284	26.4406	12.67	Yes	Yes	1	0	4
63	R:R:I259	R:R:Y255	10.4945	6.04	No	No	0	5	7
64	R:R:E288	R:R:Y255	13.8972	10.1	No	No	0	5	7
65	R:R:F276	R:R:V280	12.202	3.93	No	Yes	0	1	5
66	R:R:I284	R:R:V280	16.9949	3.07	Yes	Yes	0	4	5
67	R:R:F87	R:R:Y116	54.7716	5.16	Yes	Yes	1	7	6
68	R:R:H203	R:R:Y256	16.9218	8.71	No	Yes	0	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F87	R:R:Y116	5.16	1	Yes	Yes	7	6	2	1
R:R:F87	R:R:L120	4.87	1	Yes	No	7	7	2	2
R:R:F292	R:R:F87	8.57	1	Yes	Yes	7	7	2	2
R:R:T90	R:R:V112	3.17	0	No	No	6	5	2	2
R:R:T90	R:R:Y116	3.75	0	No	Yes	6	6	2	1
R:R:V112	R:R:W94	4.9	0	No	No	5	7	2	1
R:R:H113	R:R:W94	6.35	0	Yes	No	6	7	2	1
L:L:?1	R:R:W94	17.46	1	Yes	No	0	7	0	1
R:R:L120	R:R:Y116	4.69	1	No	Yes	7	6	2	1
R:R:F292	R:R:Y116	4.13	1	Yes	Yes	7	6	2	1
L:L:?1	R:R:Y116	5.67	1	Yes	Yes	0	6	0	1
R:R:D193	R:R:L266	9.5	0	No	No	1	3	2	1
R:R:L266	R:R:V197	4.47	0	No	No	3	3	1	2
R:R:D262	R:R:Q200	5.22	1	No	No	5	5	1	2
R:R:E288	R:R:Y255	10.1	0	No	No	5	7	1	2
R:R:G258	R:R:I284	3.53	0	No	Yes	4	4	2	1
R:R:D262	R:R:I284	4.2	1	No	Yes	5	4	1	1
L:L:?1	R:R:D262	24.09	1	Yes	No	0	5	0	1
L:L:?1	R:R:L266	5.58	1	Yes	No	0	3	0	1
L:L:?1	R:R:E277	7.48	1	Yes	No	0	2	0	1
R:R:I284	R:R:V280	3.07	1	Yes	Yes	4	5	1	2
L:L:?1	R:R:H281	7.26	1	Yes	No	0	4	0	1
L:L:?1	R:R:I284	12.67	1	Yes	Yes	0	4	0	1
R:R:E288	R:R:F292	10.49	0	No	Yes	5	7	1	2
L:L:?1	R:R:E288	19.24	1	Yes	No	0	5	0	1
R:R:H281	R:R:S285	2.79	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8U4P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	262
Number of Links	276
Number of Hubs	33
Number of Links mediated by Hubs	133
Number of Communities	4
Number of Nodes involved in Communities	31
Number of Links involved in Communities	42

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	35331
Length Of Smallest Path	3
Average Path Length	13.3742
Length of Longest Path	30
Minimum Path Strength	1.405
Average Path Strength	6.30986
Maximum Path Strength	17.94
Minimum Path Correlation	0.7
Average Path Correlation	0.9191
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.25
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.2782
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • protein binding • binding • myosin binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • bioluminescence • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development
Gene Ontology	Biological Process	• bioluminescence • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • apoptotic process • cell death • programmed cell death • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • cellular response to stimulus • chemotaxis • dendritic cell chemotaxis • response to stimulus • response to external stimulus • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • taxis • immune system process • response to chemical • mononuclear cell migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • neurogenesis • cellular developmental process • cell differentiation • regulation of response to external stimulus • regulation of chemotaxis • regulation of response to stimulus • regulation of locomotion • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • signaling • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • C-X-C chemokine receptor CXCR4 signaling pathway • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • regulation of multicellular organismal development • regulation of developmental process • positive regulation of biological process • vasculature development • regulation of vasculature development • circulatory system development • positive regulation of developmental process • positive regulation of vasculature development • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • positive regulation of response to stimulus • macrophage migration inhibitory factor signaling pathway • positive regulation of cellular process • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of metabolic process • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • positive regulation of nervous system development • cell development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell leading edge • intracellular anatomical structure • cytoplasm • anchoring junction • cell junction • intracellular organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein-containing complex • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • endomembrane system • late endosome • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	VH6
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	VH6
Name	Plerixafor
Synonyms	1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane); AMD3100
Identifier
Formula	C28 H54 N8
Molecular Weight	502.782
SMILES
PubChem	65015
Formal Charge	0
Total Atoms	90
Total Chiral Atoms	0
Total Bonds	92
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8U4P_nogp_Chain_R N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V S L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	doi.org/10.1016/j.celrep.2025.115255
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	Gi1/β1/γ2	2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ2	3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	Gi1/β1/γ2	3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.1	2024-03-13	doi.org/10.1101/2024.02.09.579708
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	doi.org/10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	doi.org/10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	doi.org/10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	doi.org/10.1126/science.1261064
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	-	-	3.01	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	-	-	3.2	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8U4P_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.