psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I39	R:R:N35	4.25	No	No	0	5	3
2	R:R:F36	R:R:F40	8.57	No	No	0	4	5
3	R:R:L41	R:R:N37	5.49	Yes	No	0	6	3
4	R:R:F40	R:R:I44	5.02	No	No	0	5	5
5	R:R:L41	R:R:Y45	4.69	Yes	No	0	6	7
6	R:R:A98	R:R:P42	3.74	No	No	0	5	5
7	R:R:P42	R:R:V99	3.53	No	No	0	5	4
8	R:R:F292	R:R:Y45	6.19	Yes	No	0	7	7
9	R:R:F293	R:R:I48	15.07	Yes	No	0	5	7
10	R:R:F49	R:R:L50	3.65	Yes	No	0	6	5
11	R:R:F49	R:R:V88	3.93	Yes	No	0	6	6
12	R:R:F49	R:R:P92	7.22	Yes	No	0	6	9
13	R:R:C296	R:R:T51	5.07	No	No	0	7	5
14	R:R:G55	R:R:V54	3.68	No	No	0	8	4
15	R:R:G55	R:R:P299	4.06	No	No	0	8	9
16	R:R:N56	R:R:S81	5.96	Yes	No	0	9	9
17	R:R:D84	R:R:N56	6.73	No	Yes	0	9	9
18	R:R:N56	R:R:P299	6.52	Yes	No	0	9	9
19	R:R:S81	R:R:V59	6.46	No	No	0	9	8
20	R:R:I60	R:R:S81	6.19	No	No	0	7	9
21	R:R:F309	R:R:V62	7.87	Yes	No	0	8	7
22	R:R:D74	R:R:M63	8.32	Yes	No	0	8	6
23	R:R:D74	R:R:Q66	3.92	Yes	No	0	8	4
24	R:R:Q66	R:R:S312	4.33	No	No	0	4	6
25	R:R:D74	R:R:R70	4.76	Yes	No	0	8	6
26	R:R:R70	W:W:?1	7.27	No	Yes	0	6	0
27	R:R:D74	R:R:S71	4.42	Yes	No	0	8	7
28	R:R:K149	R:R:M72	4.32	No	No	0	6	6
29	R:R:R77	R:R:T73	3.88	No	No	0	8	7
30	R:R:D74	R:R:R77	3.57	Yes	No	0	8	8
31	R:R:E153	R:R:K75	13.5	No	No	0	7	6
32	R:R:K75	W:W:?1	5.62	No	Yes	0	6	0
33	R:R:I130	R:R:Y76	7.25	No	Yes	0	8	7
34	R:R:D133	R:R:Y76	11.49	No	Yes	0	8	7
35	R:R:V156	R:R:Y76	5.05	No	Yes	0	5	7
36	R:R:F309	R:R:R77	6.41	Yes	No	0	8	8
37	R:R:L78	W:W:?1	9.66	No	Yes	0	5	0
38	R:R:H79	R:R:I126	3.98	Yes	No	0	9	7
39	R:R:H79	R:R:V156	5.54	Yes	No	0	9	5
40	R:R:H79	R:R:W161	6.35	Yes	Yes	4	9	9
41	R:R:H79	W:W:?1	17.95	Yes	Yes	4	9	0
42	R:R:D84	R:R:L80	4.07	No	Yes	2	9	9
43	R:R:I126	R:R:L80	5.71	No	Yes	0	7	9
44	R:R:L127	R:R:L80	5.54	No	Yes	2	8	9
45	R:R:L80	R:R:N298	6.87	Yes	No	2	9	9
46	R:R:L80	R:R:Y302	3.52	Yes	Yes	2	9	9
47	R:R:A83	R:R:S122	3.42	No	No	0	8	7
48	R:R:D84	R:R:N298	8.08	No	No	2	9	9
49	R:R:I115	R:R:L86	4.28	No	No	0	5	7
50	R:R:F87	R:R:Y116	5.16	Yes	Yes	1	7	6
51	R:R:F87	R:R:S119	9.25	Yes	No	0	7	8
52	R:R:F87	R:R:L120	4.87	Yes	No	1	7	7
53	R:R:F292	R:R:F87	8.57	Yes	Yes	1	7	7
54	R:R:F87	R:R:H294	13.58	Yes	No	0	7	9
55	R:R:C295	R:R:F87	4.19	No	Yes	0	9	7
56	R:R:C295	R:R:V88	3.42	No	No	0	9	6
57	R:R:T90	R:R:Y116	3.75	No	Yes	0	6	6
58	R:R:F93	R:R:W102	4.01	Yes	Yes	3	6	9
59	R:R:F104	R:R:F93	4.29	Yes	Yes	3	7	6
60	R:R:F93	R:R:L108	4.87	Yes	No	3	6	5
61	R:R:F93	R:R:V112	7.87	Yes	No	0	6	5
62	R:R:V112	R:R:W94	4.9	No	No	0	5	7
63	R:R:H113	R:R:W94	6.35	Yes	No	0	6	7
64	L:L:?1	R:R:W94	17.46	Yes	No	0	0	7
65	R:R:F104	R:R:V96	5.24	Yes	No	0	7	5
66	R:R:D97	R:R:W102	5.58	No	Yes	0	5	9
67	R:R:N101	R:R:R183	10.85	No	No	0	4	3
68	R:R:F104	R:R:W102	6.01	Yes	Yes	3	7	9
69	R:R:C109	R:R:W102	6.53	No	Yes	3	9	9
70	R:R:C186	R:R:W102	10.45	No	Yes	3	9	9
71	R:R:F104	R:R:Y103	15.47	Yes	No	0	7	3
72	R:R:F104	R:R:L108	3.65	Yes	No	3	7	5
73	R:R:N106	R:R:V177	5.91	No	No	0	3	4
74	R:R:C109	R:R:H113	5.9	No	Yes	0	9	6
75	R:R:C109	R:R:C186	7.28	No	No	3	9	9
76	R:R:K110	R:R:N176	5.6	No	No	0	7	4
77	R:R:D171	R:R:H113	7.56	No	Yes	0	4	6
78	R:R:A175	R:R:H113	5.85	No	Yes	0	4	6
79	R:R:T168	R:R:V114	4.76	No	No	0	6	5
80	R:R:F172	R:R:V114	10.49	No	No	0	4	5
81	R:R:L120	R:R:Y116	4.69	No	Yes	1	7	6
82	R:R:F292	R:R:Y116	4.13	Yes	Yes	1	7	6
83	L:L:?1	R:R:Y116	5.67	Yes	Yes	1	0	6
84	R:R:D171	R:R:T117	8.67	No	No	0	4	5
85	R:R:L120	R:R:Y121	3.52	No	Yes	1	7	7
86	R:R:L167	R:R:Y121	9.38	No	Yes	1	5	7
87	R:R:Q202	R:R:Y121	4.51	Yes	Yes	1	3	7
88	R:R:H203	R:R:Y121	8.71	No	Yes	0	4	7
89	R:R:V206	R:R:Y121	3.79	No	Yes	1	4	7
90	R:R:S122	R:R:W161	7.41	No	Yes	0	7	9
91	R:R:H294	R:R:S123	5.58	No	No	0	9	9
92	R:R:P211	R:R:V124	5.3	No	No	0	9	7
93	R:R:V124	R:R:W252	3.68	No	Yes	0	7	9
94	R:R:L125	R:R:V160	4.47	No	Yes	0	5	7
95	R:R:I126	R:R:V160	4.61	No	Yes	0	7	7
96	R:R:L127	R:R:Y302	9.38	No	Yes	2	8	9
97	R:R:F129	R:R:V155	5.24	No	No	0	5	2
98	R:R:F129	R:R:V160	5.24	No	Yes	0	5	7
99	R:R:I130	R:R:R134	6.26	No	No	2	8	9
100	R:R:I130	R:R:Y302	6.04	No	Yes	2	8	9
101	R:R:I215	R:R:S131	6.19	No	No	0	7	9
102	R:R:C218	R:R:S131	5.16	No	No	0	6	9
103	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
104	R:R:D133	R:R:R148	13.1	No	Yes	0	8	6
105	R:R:R134	R:R:Y219	7.2	No	Yes	0	9	8
106	R:R:R134	R:R:Y302	6.17	No	Yes	2	9	9
107	R:R:V139	R:R:Y135	10.09	No	No	0	7	8
108	R:R:I221	R:R:Y135	6.04	No	No	0	4	8
109	R:R:L136	R:R:R148	3.64	No	Yes	0	5	6
110	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
111	R:R:H140	R:R:V139	5.54	No	No	0	6	7
112	R:R:K225	R:R:V139	4.55	No	No	0	4	7
113	R:R:H140	R:R:N143	7.65	No	No	0	6	5
114	R:R:L151	R:R:V155	5.96	No	No	0	4	2
115	R:R:Y157	W:W:?1	14.03	No	Yes	0	7	0
116	R:R:G159	R:R:V158	3.68	No	No	0	3	4
117	R:R:G159	R:R:P163	4.06	No	No	0	3	4
118	R:R:V160	R:R:W161	8.58	Yes	Yes	0	7	9
119	R:R:W161	W:W:?1	9.09	Yes	Yes	4	9	0
120	R:R:L167	R:R:Q202	7.99	No	Yes	1	5	3
121	R:R:L167	R:R:V206	4.47	No	No	1	5	4
122	R:R:P170	R:R:R188	4.32	No	No	0	8	5
123	R:R:F199	R:R:P170	7.22	Yes	No	0	5	8
124	R:R:D171	R:R:R188	15.48	No	No	0	4	5
125	R:R:F174	R:R:I173	15.07	No	No	0	4	3
126	R:R:F174	R:R:Y190	6.19	No	Yes	1	4	4
127	R:R:F174	R:R:W195	6.01	No	Yes	1	4	5
128	R:R:C186	R:R:V177	3.42	No	No	0	9	4
129	R:R:I185	R:R:R183	7.52	No	No	0	3	3
130	R:R:D187	R:R:F189	9.55	No	No	0	3	3
131	R:R:R188	R:R:Y190	10.29	No	Yes	0	5	4
132	R:R:W195	R:R:Y190	3.86	Yes	Yes	1	5	4
133	R:R:V196	R:R:Y190	7.57	No	Yes	0	4	4
134	R:R:F199	R:R:Y190	14.44	Yes	Yes	1	5	4
135	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
136	R:R:D193	R:R:L266	9.5	No	No	0	1	3
137	R:R:F199	R:R:W195	6.01	Yes	Yes	1	5	5
138	R:R:F201	R:R:V197	3.93	No	No	0	4	3
139	R:R:L266	R:R:V197	4.47	No	No	0	3	3
140	R:R:F199	R:R:Q202	3.51	Yes	Yes	1	5	3
141	R:R:D262	R:R:Q200	5.22	No	No	0	5	5
142	R:R:F201	R:R:S263	5.28	No	No	0	4	5
143	R:R:Q202	R:R:V206	4.3	Yes	No	1	3	4
144	R:R:H203	R:R:Y256	8.71	No	Yes	0	4	8
145	R:R:L208	R:R:Y256	9.38	No	Yes	0	8	8
146	R:R:F248	R:R:I215	5.02	Yes	No	0	9	7
147	R:R:F249	R:R:L216	4.87	Yes	No	0	4	4
148	R:R:T241	R:R:Y219	3.75	No	Yes	0	7	8
149	R:R:L244	R:R:Y219	4.69	No	Yes	0	7	8
150	R:R:I245	R:R:Y219	4.84	No	Yes	0	7	8
151	R:R:I223	R:R:L238	4.28	No	No	0	4	5
152	R:R:I223	R:R:T241	6.08	No	No	0	4	7
153	R:R:K234	R:R:S229	12.24	No	No	0	7	5
154	R:R:H232	R:R:R235	4.51	No	No	0	4	5
155	R:R:H232	R:R:K236	14.41	No	No	0	4	8
156	R:R:L244	R:R:L301	5.54	No	Yes	0	7	7
157	R:R:F248	R:R:F249	7.5	Yes	Yes	5	9	4
158	R:R:F248	R:R:W252	6.01	Yes	Yes	0	9	9
159	R:R:F249	R:R:L253	4.87	Yes	No	0	4	5
160	R:R:W252	R:R:Y256	9.65	Yes	Yes	0	9	8
161	R:R:H294	R:R:W252	10.58	No	Yes	0	9	9
162	R:R:P254	R:R:T287	3.5	No	No	0	9	6
163	R:R:I259	R:R:Y255	6.04	No	No	0	5	7
164	R:R:E288	R:R:Y255	10.1	No	No	0	5	7
165	R:R:G258	R:R:I284	3.53	No	Yes	0	4	4
166	R:R:D262	R:R:I284	4.2	No	Yes	1	5	4
167	L:L:?1	R:R:D262	24.09	Yes	No	1	0	5
168	R:R:F264	R:R:I269	10.05	No	No	0	4	1
169	R:R:F264	R:R:I270	3.77	No	No	0	4	5
170	R:R:I265	R:R:V280	4.61	No	Yes	0	3	5
171	L:L:?1	R:R:L266	5.58	Yes	No	0	0	3
172	R:R:E268	R:R:K271	8.1	No	No	0	2	3
173	R:R:I270	R:R:Q272	4.12	No	No	0	5	2
174	R:R:F276	R:R:Q272	10.54	No	No	0	1	2
175	R:R:F276	R:R:V280	3.93	No	Yes	0	1	5
176	L:L:?1	R:R:E277	7.48	Yes	No	0	0	2
177	L:L:?1	R:R:H281	7.26	Yes	No	0	0	4
178	R:R:I286	R:R:K282	4.36	No	No	0	6	2
179	R:R:T287	R:R:W283	9.7	No	No	0	6	6
180	L:L:?1	R:R:I284	12.67	Yes	Yes	1	0	4
181	R:R:E288	R:R:F292	10.49	No	Yes	0	5	7
182	L:L:?1	R:R:E288	19.24	Yes	No	0	0	5
183	R:R:C296	R:R:F293	4.19	No	Yes	0	7	5
184	R:R:A303	R:R:F309	6.93	No	Yes	0	7	8
185	R:R:F304	R:R:F309	7.5	No	Yes	0	6	8
186	R:R:A313	R:R:V62	3.39	No	No	0	5	7
187	R:R:A128	R:R:V214	3.39	No	No	0	7	6
188	R:R:I162	R:R:P163	3.39	No	No	0	4	4
189	R:R:I169	R:R:P170	3.39	No	No	0	3	8
190	R:R:N192	R:R:P191	3.26	No	No	0	1	5
191	R:R:C218	R:R:L132	3.17	No	No	0	6	6
192	R:R:C220	R:R:L216	3.17	No	No	0	3	4
193	R:R:T117	R:R:T168	3.14	No	No	0	5	6
194	R:R:I53	R:R:V88	3.07	No	No	0	5	6
195	R:R:I284	R:R:V280	3.07	Yes	Yes	0	4	5
196	R:R:I47	R:R:T43	3.04	No	No	0	4	4
197	R:R:L136	R:R:S144	3	No	No	0	5	5
198	R:R:L267	R:R:V197	2.98	No	No	0	1	3
199	R:R:I44	R:R:I48	2.94	No	No	0	5	7
200	R:R:I138	R:R:I222	2.94	No	No	0	8	8
201	R:R:I204	R:R:I259	2.94	No	No	0	5	5
202	R:R:I209	R:R:I213	2.94	No	No	0	4	3
203	R:R:I209	R:R:M205	2.92	No	No	0	4	4
204	R:R:G207	R:R:Y256	2.9	No	Yes	0	5	8
205	R:R:I48	R:R:L91	2.85	No	No	0	7	8
206	R:R:I162	R:R:L166	2.85	No	No	0	4	4
207	R:R:G258	R:R:W283	2.81	No	No	0	4	6
208	R:R:K110	R:R:N106	2.8	No	No	0	7	3
209	R:R:H140	R:R:S144	2.79	No	No	0	6	5
210	R:R:H228	R:R:S227	2.79	No	No	0	5	4
211	R:R:H228	R:R:S229	2.79	No	No	0	5	5
212	R:R:H281	R:R:S285	2.79	No	No	0	4	5
213	R:R:L85	R:R:N56	2.75	No	Yes	0	7	9
214	R:R:H315	R:R:T311	2.74	No	No	0	4	4
215	R:R:K68	R:R:Q66	2.71	No	No	0	6	4
216	R:R:A95	R:R:Y45	2.67	No	No	0	7	7
217	R:R:A152	R:R:Y76	2.67	No	Yes	0	3	7
218	R:R:A291	R:R:Y255	2.67	No	No	0	8	7
219	R:R:D181	R:R:D182	2.66	No	No	0	2	6
220	R:R:F189	R:R:S178	2.64	No	No	0	3	1
221	R:R:C251	R:R:W252	2.61	No	Yes	0	8	9
222	R:R:F276	R:R:T279	2.59	No	No	0	1	2
223	R:R:F36	R:R:I286	2.51	No	No	0	4	6
224	R:R:F304	R:R:I300	2.51	No	No	0	6	6
225	R:R:M72	R:R:R148	2.48	No	Yes	0	6	6
226	R:R:F49	R:R:L91	2.44	Yes	No	0	6	8
227	R:R:F304	R:R:L58	2.44	No	No	0	6	5
228	R:R:F292	R:R:L91	2.44	Yes	No	0	7	8
229	R:R:F293	R:R:L297	2.44	Yes	No	0	5	6
230	R:R:I222	R:R:Y219	2.42	No	Yes	0	8	8
231	R:R:E179	R:R:Y184	2.24	No	No	0	2	5
232	R:R:C296	R:R:G52	1.96	No	No	0	7	8
233	R:R:A128	R:R:P211	1.87	No	No	0	7	9
234	R:R:G258	R:R:I257	1.76	No	No	0	4	6
235	R:R:G64	R:R:M63	1.75	No	No	0	2	6
236	R:R:G306	R:R:L305	1.71	No	No	0	8	6
237	R:R:A141	R:R:T142	1.68	No	No	0	8	5
238	R:R:L41	R:R:P42	1.64	Yes	No	0	6	5
239	R:R:L125	R:R:P163	1.64	No	No	0	5	4
240	R:R:L210	R:R:P211	1.64	No	No	0	6	9
241	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
242	R:R:A180	R:R:I185	1.62	No	No	0	1	3
243	R:R:A34	R:R:K38	1.61	No	No	0	1	4
244	R:R:V114	R:R:V118	1.6	No	No	0	5	5
245	R:R:A289	R:R:L41	1.58	No	Yes	0	4	6
246	R:R:A237	R:R:L226	1.58	No	No	0	7	8
247	R:R:A247	R:R:L301	1.58	No	Yes	0	6	7
248	R:R:C274	R:R:N278	1.57	No	No	0	5	3
249	R:R:I47	R:R:S46	1.55	No	No	0	4	5
250	R:R:I204	R:R:S260	1.55	No	No	0	5	5
251	R:R:I221	R:R:S217	1.55	No	No	0	4	3
252	R:R:I261	R:R:V280	1.54	No	Yes	0	5	5
253	R:R:K225	R:R:S224	1.53	No	No	0	4	4
254	R:R:I47	R:R:T51	1.52	No	No	0	4	5
255	R:R:I115	R:R:T90	1.52	No	No	0	5	6
256	R:R:F248	R:R:G212	1.51	Yes	No	5	9	6
257	R:R:F249	R:R:G212	1.51	Yes	No	5	4	6
258	R:R:L86	R:R:V82	1.49	No	No	0	7	5
259	R:R:L165	R:R:V118	1.49	No	No	0	3	5
260	R:R:L194	R:R:V198	1.49	No	No	0	2	3
261	R:R:I204	R:R:I209	1.47	No	No	0	5	4
262	R:R:L305	R:R:T240	1.47	No	No	0	6	7
263	R:R:N143	R:R:T142	1.46	No	No	0	5	5
264	R:R:I243	R:R:K239	1.45	No	No	0	5	6
265	R:R:P147	R:R:R146	1.44	No	No	0	4	5
266	R:R:I138	R:R:L226	1.43	No	No	0	8	8
267	R:R:I243	R:R:L301	1.43	No	Yes	0	5	7
268	R:R:K154	R:R:L150	1.41	No	No	0	3	4
269	R:R:L301	R:R:L305	1.38	Yes	No	0	7	6
270	R:R:L194	R:R:N192	1.37	No	No	0	2	1
271	R:R:D97	R:R:N101	1.35	No	No	0	5	4
272	R:R:A100	R:R:Y103	1.33	No	No	0	5	3
273	R:R:A164	R:R:Y121	1.33	No	Yes	0	7	7
274	R:R:F40	R:R:I39	1.26	No	No	0	5	5
275	R:R:D187	R:R:H113	1.26	No	Yes	0	3	6
276	R:R:V177	R:R:Y184	1.26	No	No	0	4	5
277	R:R:F293	R:R:L290	1.22	Yes	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L41	3.35	4	0	6
2	R:R:F49	4.31	4	0	6
3	R:R:N56	5.49	4	0	9
4	R:R:D74	4.998	5	0	8
5	R:R:Y76	6.615	4	0	7
6	R:R:H79	8.455	4	4	9
7	R:R:L80	5.142	5	2	9
8	R:R:F87	7.60333	6	1	7
9	R:R:F93	5.26	4	3	6
10	R:R:W102	6.516	5	3	9
11	R:R:F104	6.932	5	3	7
12	R:R:H113	5.384	5	0	6
13	R:R:Y116	4.68	5	1	6
14	R:R:Y121	5.20667	6	1	7
15	R:R:R148	6.5325	4	0	6
16	R:R:V160	5.725	4	0	7
17	R:R:W161	7.8575	4	4	9
18	R:R:Y190	8.47	5	1	4
19	R:R:W195	5.3825	4	1	5
20	R:R:F199	7.795	4	1	5
21	R:R:Q202	5.0775	4	1	3
22	R:R:Y219	4.665	6	0	8
23	R:R:F248	5.01	4	5	9
24	R:R:F249	4.6875	4	5	4
25	R:R:W252	6.506	5	0	9
26	R:R:Y256	7.66	4	0	8
27	R:R:V280	3.2875	4	0	5
28	R:R:I284	5.8675	4	1	4
29	R:R:F292	6.364	5	1	7
30	R:R:F293	5.73	4	0	5
31	R:R:L301	2.4825	4	0	7
32	R:R:Y302	6.2775	4	2	9
33	R:R:F309	7.1775	4	0	8
34	W:W:?1	10.6033	6	4	0
35	L:L:?1	12.4312	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:I44	10.9966	5.02	No	No	0	5	5
2	R:R:I44	R:R:I48	12.8268	2.94	No	No	0	5	7
3	R:R:I48	R:R:L91	30.565	2.85	No	No	0	7	8
4	R:R:F292	R:R:L91	37.2193	2.44	Yes	No	0	7	8
5	R:R:F292	R:R:Y45	14.8826	6.19	Yes	No	0	7	7
6	R:R:L41	R:R:Y45	11.2222	4.69	Yes	No	0	6	7
7	R:R:F293	R:R:I48	16.6513	15.07	Yes	No	0	5	7
8	R:R:C296	R:R:F293	11.1914	4.19	No	Yes	0	7	5
9	R:R:D84	R:R:N56	10.2071	6.73	No	Yes	0	9	9
10	R:R:D84	R:R:L80	11.3914	4.07	No	Yes	2	9	9
11	R:R:L80	R:R:Y302	48.5645	3.52	Yes	Yes	2	9	9
12	R:R:R134	R:R:Y302	48.8773	6.17	No	Yes	2	9	9
13	R:R:R134	R:R:Y219	92.4741	7.2	No	Yes	0	9	8
14	R:R:S131	R:R:Y219	98.2159	5.09	No	Yes	0	9	8
15	R:R:I215	R:R:S131	98.8926	6.19	No	No	0	7	9
16	R:R:F248	R:R:I215	99.0977	5.02	Yes	No	0	9	7
17	R:R:F248	R:R:W252	100	6.01	Yes	Yes	0	9	9
18	R:R:H294	R:R:W252	85.4404	10.58	No	Yes	0	9	9
19	R:R:F87	R:R:H294	85.4814	13.58	Yes	No	0	7	9
20	R:R:F292	R:R:F87	32.4823	8.57	Yes	Yes	1	7	7
21	R:R:F309	R:R:R77	14.3648	6.41	Yes	No	0	8	8
22	R:R:D74	R:R:R77	18.6968	3.57	Yes	No	0	8	8
23	R:R:D74	R:R:R70	33.2308	4.76	Yes	No	0	8	6
24	R:R:R70	W:W:?1	35.0149	7.27	No	Yes	0	6	0
25	R:R:H79	W:W:?1	43.7558	17.95	Yes	Yes	4	9	0
26	R:R:H79	R:R:I126	26.802	3.98	Yes	No	0	9	7
27	R:R:I126	R:R:L80	39.6135	5.71	No	Yes	0	7	9
28	R:R:H79	R:R:V156	28.5143	5.54	Yes	No	0	9	5
29	R:R:V156	R:R:Y76	29.2628	5.05	No	Yes	0	5	7
30	R:R:I130	R:R:Y76	43.6789	7.25	No	Yes	0	8	7
31	R:R:I130	R:R:R134	43.156	6.26	No	No	2	8	9
32	R:R:D133	R:R:Y76	21.4344	11.49	No	Yes	0	8	7
33	R:R:D133	R:R:R148	20.2861	13.1	No	Yes	0	8	6
34	R:R:I126	R:R:V160	14.252	4.61	No	Yes	0	7	7
35	R:R:F292	R:R:Y116	15.344	4.13	Yes	Yes	1	7	6
36	R:R:F93	R:R:V112	15.872	7.87	Yes	No	0	6	5
37	R:R:V112	R:R:W94	17.0819	4.9	No	No	0	5	7
38	L:L:?1	R:R:W94	53.7988	17.46	Yes	No	0	0	7
39	L:L:?1	R:R:Y116	65.9541	5.67	Yes	Yes	1	0	6
40	L:L:?1	R:R:E288	15.0415	19.24	Yes	No	0	0	5
41	R:R:E288	R:R:F292	20.204	10.49	No	Yes	0	5	7
42	R:R:H113	R:R:W94	36.5939	6.35	Yes	No	0	6	7
43	R:R:C109	R:R:H113	21.5472	5.9	No	Yes	0	9	6
44	R:R:D97	R:R:W102	14.0931	5.58	No	Yes	0	5	9
45	R:R:D97	R:R:N101	11.2273	1.35	No	No	0	5	4
46	R:R:C109	R:R:C186	10.4019	7.28	No	No	3	9	9
47	R:R:D171	R:R:H113	15.262	7.56	No	Yes	0	4	6
48	R:R:L120	R:R:Y121	12.914	3.52	No	Yes	1	7	7
49	R:R:Q202	R:R:Y121	20.2399	4.51	Yes	Yes	1	3	7
50	R:R:H203	R:R:Y121	16.7487	8.71	No	Yes	0	4	7
51	R:R:L136	R:R:R148	15.4465	3.64	No	Yes	0	5	6
52	R:R:L136	R:R:S144	14.211	3	No	No	0	5	5
53	R:R:H140	R:R:S144	12.9652	2.79	No	No	0	6	5
54	R:R:F199	R:R:Q202	19.9631	3.51	Yes	Yes	1	5	3
55	R:R:W252	R:R:Y256	18.8301	9.65	Yes	Yes	0	9	8
56	R:R:L244	R:R:Y219	11.1145	4.69	No	Yes	0	7	8
57	L:L:?1	R:R:I284	23.7722	12.67	Yes	Yes	1	0	4
58	R:R:E288	R:R:Y255	12.5859	10.1	No	No	0	5	7
59	R:R:F276	R:R:V280	10.8941	3.93	No	Yes	0	1	5
60	R:R:I284	R:R:V280	15.1902	3.07	Yes	Yes	0	4	5
61	R:R:F87	R:R:Y116	52.8812	5.16	Yes	Yes	1	7	6
62	R:R:H203	R:R:Y256	16.5693	8.71	No	Yes	0	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F87	R:R:Y116	5.16	1	Yes	Yes	7	6	2	1
R:R:F87	R:R:L120	4.87	1	Yes	No	7	7	2	2
R:R:F292	R:R:F87	8.57	1	Yes	Yes	7	7	2	2
R:R:T90	R:R:Y116	3.75	0	No	Yes	6	6	2	1
R:R:V112	R:R:W94	4.9	0	No	No	5	7	2	1
R:R:H113	R:R:W94	6.35	0	Yes	No	6	7	2	1
L:L:?1	R:R:W94	17.46	1	Yes	No	0	7	0	1
R:R:L120	R:R:Y116	4.69	1	No	Yes	7	6	2	1
R:R:F292	R:R:Y116	4.13	1	Yes	Yes	7	6	2	1
L:L:?1	R:R:Y116	5.67	1	Yes	Yes	0	6	0	1
R:R:D193	R:R:L266	9.5	0	No	No	1	3	2	1
R:R:L266	R:R:V197	4.47	0	No	No	3	3	1	2
R:R:D262	R:R:Q200	5.22	1	No	No	5	5	1	2
R:R:E288	R:R:Y255	10.1	0	No	No	5	7	1	2
R:R:G258	R:R:I284	3.53	0	No	Yes	4	4	2	1
R:R:D262	R:R:I284	4.2	1	No	Yes	5	4	1	1
L:L:?1	R:R:D262	24.09	1	Yes	No	0	5	0	1
L:L:?1	R:R:L266	5.58	1	Yes	No	0	3	0	1
L:L:?1	R:R:E277	7.48	1	Yes	No	0	2	0	1
L:L:?1	R:R:H281	7.26	1	Yes	No	0	4	0	1
L:L:?1	R:R:I284	12.67	1	Yes	Yes	0	4	0	1
R:R:E288	R:R:F292	10.49	0	No	Yes	5	7	1	2
L:L:?1	R:R:E288	19.24	1	Yes	No	0	5	0	1
R:R:I284	R:R:V280	3.07	1	Yes	Yes	4	5	1	2
R:R:H281	R:R:S285	2.79	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D74	R:R:R70	4.76	0	Yes	No	8	6	2	1
R:R:R70	W:W:?1	7.27	0	No	Yes	6	0	1	0
R:R:E153	R:R:K75	13.5	0	No	No	7	6	2	1
R:R:K75	W:W:?1	5.62	0	No	Yes	6	0	1	0
R:R:L78	W:W:?1	9.66	0	No	Yes	5	0	1	0
R:R:H79	R:R:I126	3.98	4	Yes	No	9	7	1	2
R:R:H79	R:R:V156	5.54	4	Yes	No	9	5	1	2
R:R:H79	R:R:W161	6.35	4	Yes	Yes	9	9	1	1
R:R:H79	W:W:?1	17.95	4	Yes	Yes	9	0	1	0
R:R:S122	R:R:W161	7.41	0	No	Yes	7	9	2	1
R:R:I126	R:R:V160	4.61	0	No	Yes	7	7	2	2
R:R:Y157	W:W:?1	14.03	0	No	Yes	7	0	1	0
R:R:V160	R:R:W161	8.58	0	Yes	Yes	7	9	2	1
R:R:W161	W:W:?1	9.09	4	Yes	Yes	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8U4P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	263
Number of Links	277
Number of Hubs	35
Number of Links mediated by Hubs	139
Number of Communities	5
Number of Nodes involved in Communities	34
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	39516
Length Of Smallest Path	3
Average Path Length	13.8556
Length of Longest Path	30
Minimum Path Strength	1.405
Average Path Strength	6.64062
Maximum Path Strength	17.94
Minimum Path Correlation	0.7
Average Path Correlation	0.917388
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.7089
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.6318
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • myosin binding • small molecule binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • bioluminescence • metabolic process • generation of precursor metabolites and energy • head development • central nervous system development • brain development • nervous system development • cell adhesion • regulation of cell adhesion • neuron recognition • cellular developmental process • cell development • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron development • cell recognition • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to ultrasound • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • forebrain development • telencephalon cell migration • forebrain cell migration • cell migration • telencephalon development • cell motility • apoptotic process • cell death • programmed cell death • epithelium development • endothelium development • tube development • morphogenesis of an endothelium • endothelial tube morphogenesis • morphogenesis of an epithelium • tissue development • tissue morphogenesis • anatomical structure morphogenesis • tube morphogenesis • epithelial tube morphogenesis • regulation of viral process • viral process • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • immune system process • mononuclear cell migration • leukocyte chemotaxis • detection of external stimulus • detection of stimulus involved in sensory perception of pain • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • epithelial cell development • epithelial cell differentiation • regulation of growth • developmental growth • cell projection organization • neuron projection development • regulation of cell morphogenesis • positive regulation of developmental process • cell projection morphogenesis • neuron projection morphogenesis • positive regulation of developmental growth • developmental growth involved in morphogenesis • positive regulation of dendrite extension • regulation of cellular component organization • regulation of developmental process • plasma membrane bounded cell projection morphogenesis • cell growth • cell morphogenesis • dendrite extension • positive regulation of cellular process • regulation of anatomical structure morphogenesis • neuron projection extension • regulation of developmental growth • plasma membrane bounded cell projection organization • developmental cell growth • growth • regulation of dendrite extension • positive regulation of cell growth • regulation of cell growth • positive regulation of growth • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • detection of mechanical stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • C-X-C chemokine receptor CXCR4 signaling pathway • response to activity • regulation of cell motility • positive regulation of mesenchymal stem cell migration • positive regulation of cell migration • regulation of mesenchymal stem cell migration • mesenchymal stem cell migration • positive regulation of cell motility • regulation of cell migration • calcium-mediated signaling • endothelial cell differentiation • angiogenesis • regulation of vasculature development • regulation of response to wounding • positive regulation of vascular wound healing • vascular wound healing • regulation of response to stress • regulation of multicellular organismal process • response to wounding • blood vessel development • positive regulation of response to wounding • wound healing • regulation of multicellular organismal development • blood vessel morphogenesis • angiogenesis involved in wound healing • positive regulation of angiogenesis • vasculature development • circulatory system development • positive regulation of vasculature development • positive regulation of wound healing • regulation of angiogenesis • regulation of wound healing • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • regulation of vascular wound healing • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • macrophage migration inhibitory factor signaling pathway • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of metabolic process • regulation of programmed cell death • response to tacrolimus • heart process • circulatory system process • cardiac muscle contraction • heart contraction • muscle contraction • muscle system process • blood circulation • striated muscle contraction • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • neuron migration • positive regulation of nervous system development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell surface • external side of plasma membrane • cell leading edge • anchoring junction • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • late endosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


Code	VH6
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	VH6
Name	Plerixafor
Synonyms	1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane); AMD3100
Identifier
Formula	C28 H54 N8
Molecular Weight	502.782
SMILES
PubChem	65015
Formal Charge	0
Total Atoms	90
Total Chiral Atoms	0
Total Bonds	92
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8U4P_nogp_Chain_R N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V S L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8YU7 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	To be published
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	To be published
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/β1/γ2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol		3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/β1/γ2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol		3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol		2.72	2024-03-13	10.1101/2024.02.09.579708
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	Cholesterol	-	3.2	2025-02-26	To be published
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	Cholesterol	-	3.01	2025-02-26	To be published
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE8 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	10.1126/science.1194396
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	10.1126/science.1194396
	3ODU (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		2.5	2010-10-27	10.1126/science.1194396

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