Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:M4 3.35450
2L:L:Q6 4.53450
3L:L:C23 5.4075450
4L:L:Y37 6.8245150
5L:L:W40 9.24333650
6L:L:F41 5.152510
7L:L:Q42 7.4325430
8L:L:P49 7.745410
9L:L:R51 6.57667610
10L:L:L52 5.48430
11L:L:I53 4.505450
12L:L:V63 5.44530
13L:L:R66 8.015630
14L:L:F67 5.758530
15L:L:D87 6.915430
16L:L:Y92 5.725400
17L:L:M94 7.984510
18L:L:W99 7.06510
19L:L:L101 5.106510
20L:L:F103 8.1875410
21L:L:E110 4.44754140
22L:L:R113 4.428500
23L:L:P118 7.035460
24L:L:F121 3.74400
25L:L:I122 3.6675480
26L:L:F123 4.996500
27L:L:E128 8.8985100
28L:L:W153 7.84167680
29L:L:T177 5.985400
30L:L:Y178 7.6654140
31L:L:L184 8.025480
32L:L:Y191 6.5865110
33L:L:H194 9.6354110
34L:L:Y197 8.4825110
35L:L:V201 4.725460
36L:L:H203 6.735460
37L:L:R216 5.88254110
38N:N:L4 4.118520
39N:N:Q6 5.2925420
40N:N:V18 4.8054170
41N:N:Y27 4.528520
42N:N:F29 4.91420
43N:N:S31 3.7954120
44N:N:Y32 8.344120
45N:N:W36 10.8525420
46N:N:R38 8.6575420
47N:N:W47 5.7600
48N:N:W50 6.068510
49N:N:S52 3.0925400
50N:N:T53 3.945420
51N:N:N55 8.91754180
52N:N:Y60 9.0425400
53N:N:R67 6.0825400
54N:N:V68 5.0575400
55N:N:T78 5.265400
56N:N:M81 7.685420
57N:N:L83 3.6525400
58N:N:Y94 4.81620
59N:N:Y95 5.942510
60N:N:H99 6.356510
61N:N:I101 4.13400
62N:N:Y107 4.1075400
63N:N:Y108 6.334500
64N:N:Y111 7.724500
65N:N:M113 5.6375410
66N:N:W116 6.625610
67N:N:T129 3.754130
68N:N:V134 4.498540
69N:N:F135 9.93754100
70N:N:P139 2.455400
71N:N:Y158 6.5625400
72N:N:P160 6.6525130
73N:N:W167 7.0125440
74N:N:L172 1.8675440
75N:N:F179 4.88754160
76N:N:Y207 5.4725400
77N:N:H213 8.0465130
78N:N:P215 6.1854130
79R:R:P27 5.6175415
80R:R:F29 8.314514
81R:R:F49 3.688506
82R:R:D74 5.684218
83R:R:Y76 4.814597
84R:R:D84 5.8225209
85R:R:F87 7.48254197
86R:R:W102 8.5645229
87R:R:F104 8.3525407
88R:R:H113 5.8825476
89R:R:Y121 5.19407
90R:R:Y135 6.634248
91R:R:R148 8.3825406
92R:R:V156 5.175495
93R:R:S178 4.19754121
94R:R:I185 3.8854123
95R:R:F189 4.1945123
96R:R:Y190 9.042574
97R:R:W195 4.1425475
98R:R:F199 7.18475
99R:R:H203 6.414234
100R:R:P211 2.58409
101R:R:C218 3.125406
102R:R:Y219 5.39408
103R:R:F248 5.705409
104R:R:W252 6.4475409
105R:R:Y255 5.6965237
106R:R:Y256 6.66238
107R:R:D262 5.5675405
108R:R:F292 6.20254197
109R:R:H294 6.585409
110R:R:L301 2.4825407
111R:R:F309 6.91408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:C23 L:L:Q6 31.18854.58YesYes500
2L:L:G106 L:L:Q6 60.63043.29NoYes000
3L:L:G106 L:L:Y92 61.72494.35NoYes000
4L:L:Y92 N:N:I45 1003.63YesNo000
5L:L:F103 N:N:I45 86.522711.3YesNo000
6L:L:C93 L:L:Q6 28.23584.58NoYes500
7L:L:F90 L:L:Y92 95.12269.28NoYes000
8L:L:F90 L:L:K108 94.83738.69NoNo000
9L:L:E110 L:L:K108 94.26674.05YesNo000
10L:L:E110 L:L:Y178 92.54325.61YesYes1400
11L:L:F144 L:L:Y178 91.35844.13NoYes000
12L:L:F144 L:L:P118 90.76724.33NoYes000
13L:L:H203 L:L:P118 10.061513.73YesYes600
14L:L:H203 L:L:P146 10.28874.58YesNo000
15L:L:C23 L:L:W40 28.01896.53YesYes500
16L:L:I53 L:L:W40 49.28478.22YesYes500
17L:L:I53 L:L:R59 39.31653.76YesNo000
18L:L:R59 L:L:V63 37.64076.54NoYes000
19L:L:L52 L:L:V63 13.70182.98YesYes300
20L:L:C93 L:L:W40 27.839614.37NoYes500
21L:L:P64 L:L:V63 15.41815.3NoYes300
22L:L:F103 L:L:F41 80.32975.36YesYes100
23L:L:F41 L:L:R51 83.89665.34YesYes100
24L:L:Q43 L:L:Y92 28.92535.64NoYes000
25N:N:I45 N:N:Q39 14.50229.61NoNo000
26L:L:Q43 N:N:Q39 14.045211.52NoNo000
27N:N:Q39 N:N:Y95 28.25764.51NoYes000
28L:L:R51 R:R:D181 84.77968.34YesNo102
29L:L:L206 L:L:P118 80.1118.21NoYes600
30L:L:L206 L:L:V210 81.8512.98NoNo600
31L:L:V201 L:L:V210 81.13433.21YesNo600
32L:L:V151 L:L:V201 80.49346.41NoYes600
33L:L:S182 L:L:V151 80.24873.23NoNo000
34L:L:S182 L:L:W153 79.92599.88NoYes000
35L:L:V137 L:L:W153 56.14994.9NoYes800
36L:L:P125 L:L:V137 56.11783.53NoNo000
37L:L:P125 L:L:Y191 55.76755.56NoYes000
38L:L:L130 L:L:Y191 46.72862.34NoYes000
39L:L:K188 L:L:L130 46.35384.23NoNo000
40L:L:G133 L:L:K188 45.97833.49NoNo000
41L:L:G133 L:L:T134 45.6021.82NoNo000
42L:L:T134 N:N:K156 45.22494.5NoNo000
43N:N:K156 N:N:Q184 44.8479.49NoNo000
44N:N:Q184 N:N:S190 44.46858.66NoNo000
45N:N:S190 N:N:V182 44.08911.62NoNo000
46L:L:S167 N:N:V182 43.7093.23NoNo000
47L:L:S167 L:L:S181 43.32811.63NoNo000
48L:L:S181 N:N:F179 42.9466.61NoYes000
49L:L:L140 N:N:F179 41.41182.44NoYes000
50L:L:F121 L:L:L140 41.02676.09YesNo000
51L:L:C139 L:L:W153 10.47345.22NoYes800
52L:L:C139 L:L:I122 10.08143.27NoYes800
53L:L:C199 L:L:W153 10.47345.22NoYes800
54L:L:C199 L:L:I122 10.08143.27NoYes800
55L:L:F214 L:L:I122 18.65723.77NoYes000
56L:L:F121 L:L:F123 39.47712.14YesYes000
57L:L:F123 N:N:P139 36.34122.89YesYes000
58N:N:L151 N:N:P139 35.15263.28NoYes000
59N:N:L151 N:N:V224 25.9917.45NoNo000
60N:N:P136 N:N:V224 25.57835.3NoNo000
61L:L:H194 L:L:Y197 18.79763.27YesYes1100
62L:L:D156 L:L:H194 16.31613.87NoYes000
63L:L:D156 L:L:V196 15.06554.38NoNo000
64L:L:S213 L:L:V196 13.81423.23NoNo000
65L:L:A198 L:L:S213 12.56223.42NoNo000
66L:L:A198 L:L:T211 11.30941.68NoNo000
67L:L:E200 L:L:T211 10.05589.88NoNo000
68L:L:F214 L:L:Y197 15.64079.28NoYes000
69N:N:I101 N:N:Y108 48.6853.63YesYes000
70N:N:I101 N:N:Y32 11.15643.63YesYes000
71N:N:R98 N:N:Y32 11.256219.55NoYes000
72N:N:R98 N:N:Y27 11.44027.2NoYes000
73N:N:Y111 R:R:D181 84.93876.9YesNo002
74N:N:I101 N:N:Y111 45.29034.84YesYes000
75N:N:G119 N:N:Y95 42.76064.35NoYes000
76N:N:G119 N:N:Q6 42.22714.93NoYes000
77N:N:C22 N:N:Q6 10.04013.05NoYes200
78N:N:C22 N:N:L4 18.10084.76NoYes200
79N:N:L4 N:N:Y27 16.44453.52YesYes200
80N:N:C96 N:N:Q6 31.4996.1NoYes200
81N:N:C96 N:N:W36 39.342810.45NoYes200
82N:N:V20 N:N:W36 10.91517.36NoYes000
83N:N:S7 N:N:V20 10.27911.62NoNo000
84N:N:M81 N:N:W36 24.623419.78YesYes200
85N:N:M81 N:N:Y94 17.75473.59YesYes200
86N:N:K222 N:N:P136 21.42145.02NoNo000
87N:N:K222 N:N:V134 18.82553.04NoYes400
88N:N:V134 N:N:V155 15.99714.81YesNo000
89N:N:V155 N:N:Y158 15.56615.05NoYes000
90N:N:V163 N:N:Y158 12.52787.57NoYes000
91N:N:H213 N:N:V163 12.09075.54YesNo000
92N:N:Y108 R:R:R30 89.53163.09YesNo005
93R:R:H281 R:R:R30 89.202712.41NoNo045
94R:R:E277 R:R:H281 10.7354.92NoNo024
95R:R:D262 R:R:H281 81.559210.08YesNo054
96R:R:D262 R:R:Q200 65.73343.92YesNo055
97R:R:I259 R:R:Q200 64.58736.86NoNo055
98R:R:I259 R:R:Y255 64.203710.88NoYes057
99R:R:Y255 R:R:Y256 55.96024.96YesYes2378
100R:R:W252 R:R:Y256 54.27457.72YesYes098
101R:R:H294 R:R:W252 48.12411.64YesYes099
102R:R:H294 R:R:S123 47.60394.18YesNo099
103R:R:D84 R:R:S123 47.18824.42YesNo099
104R:R:D84 R:R:L80 29.80225.43YesNo2099
105R:R:I126 R:R:L80 29.37655.71NoNo079
106R:R:I126 R:R:V160 28.9264.61NoNo077
107R:R:V160 R:R:W161 28.47488.58NoNo079
108R:R:H79 R:R:W161 27.11646.35NoNo099
109R:R:H79 R:R:V156 26.66214.15NoYes095
110R:R:V156 R:R:Y76 22.88995.05YesYes957
111R:R:D133 R:R:Y76 13.63075.75NoYes087
112R:R:D133 R:R:R148 13.154214.29NoYes086
113R:R:D262 R:R:L266 14.10454.07YesNo053
114R:R:L266 R:R:V196 12.70942.98NoNo034
115R:R:V196 R:R:Y190 12.24636.31NoYes044
116N:N:H110 N:N:Y111 41.101617.42NoYes000
117L:L:P49 L:L:Q43 15.013511.05YesNo000
118N:N:H110 N:N:Y108 40.08747.62NoYes000
119L:L:P49 N:N:Y95 13.95615.56YesYes100
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:D33 R:R:E32 5.2 0 No No 0 4 0 1
L:L:R51 R:R:D181 8.34 1 Yes No 0 2 0 1
L:L:K55 R:R:D182 8.3 15 No No 0 6 0 1
L:L:W99 R:R:F29 4.01 1 Yes Yes 0 4 0 1
N:N:S31 R:R:S178 3.26 12 Yes Yes 0 1 0 1
N:N:S31 R:R:F189 3.96 12 Yes Yes 0 3 0 1
N:N:Y32 R:R:S178 3.82 12 Yes Yes 0 1 0 1
N:N:W50 R:R:P27 5.4 1 Yes Yes 0 5 0 1
N:N:W50 R:R:F29 7.02 1 Yes Yes 0 4 0 1
N:N:Y54 R:R:D193 6.9 18 No No 0 1 0 1
N:N:N55 R:R:D193 14.81 18 Yes No 0 1 0 1
N:N:R58 R:R:M24 7.44 0 No No 0 2 0 1
N:N:N59 R:R:E26 3.94 1 No No 0 2 0 1
N:N:N59 R:R:P27 8.15 1 No Yes 0 5 0 1
N:N:I101 R:R:I185 4.42 0 Yes Yes 0 3 0 1
N:N:G103 R:R:F189 3.01 0 No Yes 0 3 0 1
N:N:A104 R:R:D187 4.63 0 No No 0 3 0 1
N:N:R105 R:R:D187 3.57 0 No No 0 3 0 1
N:N:N106 R:R:I185 4.25 0 No Yes 0 3 0 1
N:N:N106 R:R:D187 6.73 0 No No 0 3 0 1
N:N:Y107 R:R:F29 4.13 0 Yes Yes 0 4 0 1
N:N:Y108 R:R:R30 3.09 0 Yes No 0 5 0 1
N:N:Y108 R:R:E32 3.37 0 Yes No 0 4 0 1
N:N:Y109 R:R:F29 20.63 1 No Yes 0 4 0 1
N:N:Y111 R:R:A180 5.34 0 Yes No 0 1 0 1
N:N:Y111 R:R:D181 6.9 0 Yes No 0 2 0 1
N:N:Y111 R:R:R183 4.12 0 Yes No 0 3 0 1
N:N:G112 R:R:D181 3.35 1 No No 0 2 0 1
R:R:E26 R:R:P27 3.14 1 No Yes 2 5 1 1
R:R:F29 R:R:P27 5.78 1 Yes Yes 4 5 1 1
R:R:H281 R:R:R30 12.41 0 No No 4 5 2 1
R:R:N101 R:R:R183 6.03 0 No No 4 3 2 1
R:R:F189 R:R:N176 3.62 12 Yes No 3 4 1 2
R:R:I185 R:R:S178 3.1 12 Yes Yes 3 1 1 1
R:R:F189 R:R:S178 6.61 12 Yes Yes 3 1 1 1
R:R:F189 R:R:I185 3.77 12 Yes Yes 3 3 1 1
R:R:E26 R:R:K25 2.7 1 No No 2 4 1 2
R:R:E32 R:R:N37 2.63 0 No No 4 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8U4Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.98
Number of Linked Nodes 679
Number of Links 766
Number of Hubs 111
Number of Links mediated by Hubs 400
Number of Communities 24
Number of Nodes involved in Communities 149
Number of Links involved in Communities 193
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 518843
Length Of Smallest Path 3
Average Path Length 30.4173
Length of Longest Path 79
Minimum Path Strength 1.4
Average Path Strength 6.05404
Maximum Path Strength 16.875
Minimum Path Correlation 0.7
Average Path Correlation 0.979368
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 67.8359
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.0546
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • cytoskeletal protein binding   • myosin light chain binding   • myosin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-X-C motif chemokine 12 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • virus receptor activity   • exogenous protein binding   • C-C chemokine receptor activity   • ubiquitin binding   • ubiquitin-like protein binding   • actin binding   • bioluminescence   • generation of precursor metabolites and energy   • head development   • central nervous system development   • brain development   • nervous system development   • cell adhesion   • regulation of cell adhesion   • apoptotic process   • cell death   • programmed cell death   • membrane organization   • myelination   • myelin maintenance   • axon ensheathment   • ensheathment of neurons   • plasma membrane organization   • endomembrane system organization   • cell chemotaxis   • chemotaxis   • dendritic cell chemotaxis   • response to external stimulus   • dendritic cell migration   • taxis   • leukocyte chemotaxis   • locomotion   • response to decreased oxygen levels   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • positive regulation of cytosolic calcium ion concentration   • neurogenesis   • cellular developmental process   • cell differentiation   • immune response   • chemokine (C-X-C motif) ligand 12 signaling pathway   • CXCL12-activated CXCR4 signaling pathway   • C-X-C chemokine receptor CXCR4 signaling pathway   • calcium-mediated signaling   • regulation of multicellular organismal development   • regulation of developmental process   • vasculature development   • regulation of vasculature development   • circulatory system development   • positive regulation of developmental process   • positive regulation of vasculature development   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of macrophage migration inhibitory factor signaling pathway   • positive regulation of response to cytokine stimulus   • positive regulation of response to stimulus   • macrophage migration inhibitory factor signaling pathway   • regulation of macrophage migration inhibitory factor signaling pathway   • regulation of cytokine-mediated signaling pathway   • regulation of response to cytokine stimulus   • regulation of response to stimulus   • positive regulation of cytokine-mediated signaling pathway   • positive regulation of signaling   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to external biotic stimulus   • response to virus   • response to biotic stimulus   • defense response   • inflammatory response   • positive regulation of nervous system development   • cell development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of gliogenesis   • positive regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • gliogenesis   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • oligodendrocyte differentiation   • glial cell differentiation   • regulation of oligodendrocyte differentiation   • cell surface   • external side of plasma membrane   • cell leading edge   • anchoring junction   • cytoplasmic vesicle   • intracellular vesicle   • early endosome   • endosome   • late endosome
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP61073
Sequence
>8U4Q_nogp_Chain_R
MKEPCFREE NANFNKIFL PTIYSIIFL TGIVGNGLV ILVMGYQKK 
LRSMTDKYR LHLSVADLL FVITLPFWA VDAVANWYF GNFLCKAVH 
VIYTVSLYS SVLILAFIS LDRYLAIVH ATNSQRPRK LLAEKVVYV 
GVWIPALLL TIPDFIFAN VSEADDRYI CDRFYPNDL WVVVFQFQH 
IMVGLILPG IVILSCYCI IISKLSHSK GHQKRKALK TTVILILAF 
FACWLPYYI GISIDSFIL LEIIKQGCE FENTVHKWI SITEALAFF 
HCCLNPILY AFLGAKFKT SAQHALT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-27doi.org/10.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-27doi.org/10.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-27doi.org/10.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-11doi.org/10.1126/science.1261064
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116--3.012025-02-26doi.org/10.1073/pnas.2425795122
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070--3.22025-02-26doi.org/10.1073/pnas.2425795122
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-05doi.org/10.1016/j.celrep.2025.115255
9MDUAProteinChemokineCXCR4Homo sapiens---2.92025-09-10To be published
9ME1AProteinChemokineCXCR4Homo sapiensCXCL12--3.372025-09-10To be published
9MEJAProteinChemokineCXCR4Homo sapiensGp120--3.992025-09-10To be published
9MENAProteinChemokineCXCR4Homo sapiensGp120 (V3 loop)--3.572025-09-10To be published
9METAProteinChemokineCXCR4Homo sapiensGp120; CD4--5.652025-09-10To be published
9MEUAProteinChemokineCXCR4Homo sapiensCXCL12--3.462025-09-10To be published
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens--2.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-3.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.12024-03-13doi.org/10.1101/2024.02.09.579708
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1




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