psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F36	R:R:F40	4.29	No	Yes	0	4	5
2	R:R:F36	R:R:K282	9.93	No	No	0	4	2
3	R:R:L41	R:R:N37	5.49	Yes	No	0	6	3
4	R:R:F40	R:R:I44	16.33	Yes	No	0	5	5
5	R:R:F40	R:R:I286	5.02	Yes	No	0	5	6
6	R:R:L41	R:R:P42	3.28	Yes	No	0	6	5
7	R:R:L41	R:R:Y45	5.86	Yes	Yes	0	6	7
8	R:R:A98	R:R:P42	3.74	No	No	0	5	5
9	R:R:P42	R:R:V99	3.53	No	No	0	5	4
10	R:R:E288	R:R:Y45	4.49	No	Yes	1	5	7
11	R:R:F292	R:R:Y45	10.32	Yes	Yes	1	7	7
12	R:R:F293	R:R:I48	12.56	No	No	4	5	7
13	R:R:C296	R:R:I48	6.55	No	No	4	7	7
14	R:R:F49	R:R:V88	3.93	No	Yes	0	6	6
15	R:R:F49	R:R:P92	8.67	No	No	0	6	9
16	R:R:C296	R:R:T51	3.38	No	No	0	7	5
17	R:R:G52	R:R:V88	3.68	No	Yes	0	8	6
18	R:R:G55	R:R:V54	3.68	No	No	0	8	4
19	R:R:G55	R:R:P299	4.06	No	No	0	8	9
20	R:R:D84	R:R:N56	12.12	Yes	No	0	9	9
21	R:R:N56	R:R:P299	13.03	No	No	0	9	9
22	R:R:F304	R:R:L58	3.65	Yes	No	0	6	5
23	R:R:S81	R:R:V59	8.08	No	No	0	9	8
24	R:R:A303	R:R:V59	5.09	No	No	2	7	8
25	R:R:F309	R:R:V59	5.24	Yes	No	2	8	8
26	R:R:I60	R:R:S81	4.64	No	No	0	7	9
27	R:R:F309	R:R:V62	7.87	Yes	No	0	8	7
28	R:R:S312	R:R:V62	3.23	No	No	0	6	7
29	R:R:A313	R:R:V62	3.39	No	No	0	5	7
30	R:R:M63	R:R:R70	6.2	No	Yes	2	6	6
31	R:R:D74	R:R:M63	8.32	Yes	No	2	8	6
32	R:R:M63	R:R:R77	6.2	No	Yes	2	6	8
33	R:R:K68	R:R:Q66	5.42	No	Yes	0	6	4
34	R:R:Q66	R:R:R70	3.5	Yes	Yes	2	4	6
35	R:R:D74	R:R:Q66	6.53	Yes	Yes	2	8	4
36	R:R:Q66	R:R:S312	4.33	Yes	No	0	4	6
37	R:R:D74	R:R:R70	3.57	Yes	Yes	2	8	6
38	R:R:L78	R:R:R70	6.07	No	Yes	0	5	6
39	R:R:S71	R:R:T73	4.8	No	No	0	7	7
40	R:R:D74	R:R:S71	8.83	Yes	No	0	8	7
41	R:R:K75	R:R:M72	4.32	No	No	0	6	6
42	R:R:M72	R:R:R148	4.96	No	Yes	0	6	6
43	R:R:D74	R:R:R77	3.57	Yes	Yes	2	8	8
44	R:R:E153	R:R:K75	8.1	No	No	0	7	6
45	R:R:F129	R:R:Y76	8.25	Yes	Yes	1	5	7
46	R:R:I130	R:R:Y76	6.04	No	Yes	1	8	7
47	R:R:D133	R:R:Y76	10.34	No	Yes	0	8	7
48	R:R:L151	R:R:Y76	3.52	Yes	Yes	1	4	7
49	R:R:A152	R:R:Y76	4	No	Yes	0	3	7
50	R:R:V156	R:R:Y76	3.79	Yes	Yes	1	5	7
51	R:R:A303	R:R:R77	4.15	No	Yes	2	7	8
52	R:R:F309	R:R:R77	9.62	Yes	Yes	2	8	8
53	R:R:H79	R:R:I126	3.98	Yes	No	0	9	7
54	R:R:H79	R:R:V156	9.69	Yes	Yes	1	9	5
55	R:R:H79	R:R:Y157	7.62	Yes	No	1	9	7
56	R:R:H79	R:R:W161	7.41	Yes	No	0	9	9
57	R:R:D84	R:R:L80	4.07	Yes	Yes	1	9	9
58	R:R:I126	R:R:L80	5.71	No	Yes	0	7	9
59	R:R:L127	R:R:L80	5.54	No	Yes	1	8	9
60	R:R:L80	R:R:N298	8.24	Yes	Yes	1	9	9
61	R:R:L80	R:R:Y302	3.52	Yes	Yes	1	9	9
62	R:R:A83	R:R:S122	3.42	No	No	0	8	7
63	R:R:D84	R:R:S123	4.42	Yes	No	0	9	9
64	R:R:C295	R:R:D84	4.67	Yes	Yes	1	9	9
65	R:R:D84	R:R:N298	8.08	Yes	Yes	1	9	9
66	R:R:F87	R:R:L91	4.87	Yes	No	0	7	8
67	R:R:F87	R:R:Y116	6.19	Yes	Yes	1	7	6
68	R:R:F87	R:R:S119	9.25	Yes	No	0	7	8
69	R:R:F87	R:R:L120	4.87	Yes	Yes	1	7	7
70	R:R:F292	R:R:F87	13.93	Yes	Yes	1	7	7
71	R:R:F87	R:R:H294	6.79	Yes	Yes	1	7	9
72	R:R:C295	R:R:F87	6.98	Yes	Yes	1	9	7
73	R:R:C295	R:R:V88	3.42	Yes	Yes	0	9	6
74	R:R:T90	R:R:W94	6.06	No	No	1	6	7
75	R:R:T90	R:R:Y116	4.99	No	Yes	1	6	6
76	R:R:F93	R:R:W102	8.02	Yes	Yes	3	6	9
77	R:R:F104	R:R:F93	5.36	Yes	Yes	3	7	6
78	R:R:F93	R:R:L108	8.53	Yes	Yes	3	6	5
79	R:R:F93	R:R:V112	11.8	Yes	No	0	6	5
80	R:R:H113	R:R:W94	9.52	Yes	No	0	6	7
81	R:R:W94	R:R:Y116	5.79	No	Yes	1	7	6
82	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
83	R:R:D97	R:R:N101	5.39	No	No	0	5	4
84	R:R:D97	R:R:W102	3.35	No	Yes	0	5	9
85	R:R:N101	R:R:R183	13.26	No	No	0	4	3
86	R:R:I185	R:R:N101	5.66	No	No	0	3	4
87	R:R:F104	R:R:W102	20.04	Yes	Yes	3	7	9
88	R:R:L108	R:R:W102	4.56	Yes	Yes	3	5	9
89	R:R:C109	R:R:W102	9.14	No	Yes	3	9	9
90	R:R:C186	R:R:W102	14.37	No	Yes	3	9	9
91	R:R:F104	R:R:Y103	4.13	Yes	No	0	7	3
92	R:R:F104	R:R:L108	6.09	Yes	Yes	3	7	5
93	R:R:K110	R:R:N106	5.6	No	No	5	7	3
94	R:R:N106	R:R:N176	5.45	No	No	5	3	4
95	R:R:N106	R:R:V177	7.39	No	No	0	3	4
96	R:R:C109	R:R:C186	7.28	No	No	3	9	9
97	R:R:A175	R:R:K110	3.21	No	No	0	4	7
98	R:R:K110	R:R:N176	5.6	No	No	5	7	4
99	R:R:D171	R:R:H113	10.08	Yes	Yes	0	4	6
100	R:R:A175	R:R:H113	4.39	No	Yes	0	4	6
101	R:R:T168	R:R:V114	7.93	No	No	0	6	5
102	R:R:D171	R:R:V114	4.38	Yes	No	0	4	5
103	R:R:F172	R:R:V114	11.8	No	No	0	4	5
104	R:R:L120	R:R:Y116	4.69	Yes	Yes	1	7	6
105	R:R:F292	R:R:Y116	4.13	Yes	Yes	1	7	6
106	R:R:D171	R:R:T117	5.78	Yes	No	0	4	5
107	R:R:T168	R:R:V118	4.76	No	No	0	6	5
108	R:R:L120	R:R:Y121	4.69	Yes	Yes	1	7	7
109	R:R:H203	R:R:L120	3.86	Yes	Yes	1	4	7
110	R:R:L120	R:R:W252	4.56	Yes	Yes	0	7	9
111	R:R:L167	R:R:Y121	9.38	No	Yes	1	5	7
112	R:R:Q202	R:R:Y121	3.38	No	Yes	1	3	7
113	R:R:H203	R:R:Y121	8.71	Yes	Yes	1	4	7
114	R:R:V206	R:R:Y121	10.09	No	Yes	1	4	7
115	R:R:S122	R:R:W161	8.65	No	No	0	7	9
116	R:R:H294	R:R:S123	5.58	Yes	No	0	9	9
117	R:R:P211	R:R:V124	5.3	Yes	No	0	9	7
118	R:R:V124	R:R:W252	3.68	No	Yes	0	7	9
119	R:R:L125	R:R:V160	4.47	No	Yes	0	5	7
120	R:R:L125	R:R:P211	3.28	No	Yes	0	5	9
121	R:R:I126	R:R:V160	4.61	No	Yes	0	7	7
122	R:R:L127	R:R:N298	6.87	No	Yes	1	8	9
123	R:R:L127	R:R:Y302	10.55	No	Yes	1	8	9
124	R:R:A128	R:R:V214	3.39	No	No	0	7	6
125	R:R:F129	R:R:L151	3.65	Yes	Yes	1	5	4
126	R:R:F129	R:R:V155	5.24	Yes	No	1	5	2
127	R:R:F129	R:R:V156	3.93	Yes	Yes	1	5	5
128	R:R:F129	R:R:V160	6.55	Yes	Yes	1	5	7
129	R:R:I130	R:R:R134	6.26	No	Yes	1	8	9
130	R:R:I130	R:R:Y302	6.04	No	Yes	1	8	9
131	R:R:I215	R:R:S131	7.74	No	No	0	7	9
132	R:R:C218	R:R:S131	5.16	No	No	0	6	9
133	R:R:S131	R:R:Y219	13.99	No	Yes	0	9	8
134	R:R:L132	R:R:L151	5.54	No	Yes	0	6	4
135	R:R:D133	R:R:R148	14.29	No	Yes	0	8	6
136	R:R:R134	R:R:Y219	10.29	Yes	Yes	1	9	8
137	R:R:L244	R:R:R134	3.64	Yes	Yes	1	7	9
138	R:R:R134	R:R:Y302	7.2	Yes	Yes	1	9	9
139	R:R:V139	R:R:Y135	12.62	No	Yes	6	7	8
140	R:R:H140	R:R:Y135	7.62	No	Yes	6	6	8
141	R:R:C218	R:R:Y135	4.03	No	Yes	0	6	8
142	R:R:I221	R:R:Y135	6.04	No	Yes	0	4	8
143	R:R:L136	R:R:S144	4.5	No	No	0	5	5
144	R:R:L136	R:R:R148	4.86	No	Yes	0	5	6
145	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
146	R:R:H140	R:R:V139	11.07	No	No	6	6	7
147	R:R:K225	R:R:V139	4.55	No	No	0	4	7
148	R:R:H140	R:R:N143	3.83	No	No	0	6	5
149	R:R:L151	R:R:V155	4.47	Yes	No	1	4	2
150	R:R:V156	R:R:Y157	6.31	Yes	No	1	5	7
151	R:R:V156	R:R:V160	3.21	Yes	Yes	1	5	7
152	R:R:G159	R:R:P163	4.06	No	No	0	3	4
153	R:R:V160	R:R:W161	7.36	Yes	No	0	7	9
154	R:R:I162	R:R:P163	3.39	No	No	0	4	4
155	R:R:L167	R:R:Q202	3.99	No	No	1	5	3
156	R:R:L167	R:R:V206	4.47	No	No	1	5	4
157	R:R:I169	R:R:P170	3.39	No	No	0	3	8
158	R:R:F199	R:R:P170	5.78	Yes	No	0	5	8
159	R:R:D171	R:R:R188	5.96	Yes	No	0	4	5
160	R:R:F174	R:R:I173	8.79	Yes	No	0	4	3
161	R:R:F174	R:R:Y190	8.25	Yes	Yes	1	4	4
162	R:R:F174	R:R:P191	4.33	Yes	Yes	1	4	5
163	R:R:F174	R:R:W195	7.02	Yes	Yes	1	4	5
164	R:R:C186	R:R:V177	6.83	No	No	0	9	4
165	R:R:F189	R:R:S178	6.61	No	No	0	3	1
166	R:R:D181	R:R:D182	6.65	No	No	0	2	6
167	R:R:D187	R:R:F189	14.33	No	No	0	3	3
168	R:R:R188	R:R:Y190	14.4	No	Yes	1	5	4
169	R:R:F199	R:R:R188	4.28	Yes	No	1	5	5
170	R:R:P191	R:R:Y190	4.17	Yes	Yes	1	5	4
171	R:R:V196	R:R:Y190	6.31	No	Yes	0	4	4
172	R:R:F199	R:R:Y190	11.35	Yes	Yes	1	5	4
173	R:R:N192	R:R:P191	3.26	No	Yes	1	1	5
174	R:R:P191	R:R:W195	8.11	Yes	Yes	1	5	5
175	R:R:L194	R:R:N192	4.12	No	No	0	2	1
176	R:R:N192	R:R:W195	6.78	No	Yes	1	1	5
177	R:R:F199	R:R:W195	7.02	Yes	Yes	1	5	5
178	R:R:F201	R:R:V197	3.93	No	No	0	4	3
179	R:R:L267	R:R:V197	8.94	No	No	0	1	3
180	R:R:F199	R:R:Q202	3.51	Yes	No	1	5	3
181	R:R:I259	R:R:Q200	5.49	No	No	0	5	5
182	R:R:D262	R:R:Q200	6.53	No	No	0	5	5
183	R:R:Q200	R:R:S263	10.11	No	No	0	5	5
184	R:R:F201	R:R:S263	6.61	No	No	0	4	5
185	R:R:H203	R:R:Y255	3.27	Yes	Yes	1	4	7
186	R:R:H203	R:R:Y256	13.07	Yes	Yes	1	4	8
187	R:R:I204	R:R:Y256	3.63	Yes	Yes	0	5	8
188	R:R:I204	R:R:I259	5.89	Yes	No	0	5	5
189	R:R:I204	R:R:S260	4.64	Yes	No	0	5	5
190	R:R:I209	R:R:M205	4.37	No	No	0	4	4
191	R:R:G207	R:R:V206	3.68	No	No	0	5	4
192	R:R:L208	R:R:Y256	12.89	No	Yes	0	8	8
193	R:R:L210	R:R:P211	3.28	No	Yes	0	6	9
194	R:R:F248	R:R:I215	7.54	Yes	No	0	9	7
195	R:R:F249	R:R:L216	10.96	No	No	0	4	4
196	R:R:T241	R:R:Y219	6.24	No	Yes	0	7	8
197	R:R:L244	R:R:Y219	4.69	Yes	Yes	1	7	8
198	R:R:I245	R:R:Y219	6.04	No	Yes	0	7	8
199	R:R:I223	R:R:T241	6.08	No	No	0	4	7
200	R:R:K225	R:R:S224	4.59	No	No	0	4	4
201	R:R:H228	R:R:S229	5.58	No	No	0	5	5
202	R:R:K234	R:R:S229	12.24	No	No	0	7	5
203	R:R:H232	R:R:R235	3.39	No	No	0	4	5
204	R:R:H232	R:R:K236	15.72	No	No	0	4	8
205	R:R:K236	R:R:K239	4.31	No	No	0	8	6
206	R:R:L244	R:R:L301	4.15	Yes	Yes	0	7	7
207	R:R:L244	R:R:Y302	5.86	Yes	Yes	1	7	9
208	R:R:F248	R:R:F249	10.72	Yes	No	7	9	4
209	R:R:F248	R:R:W252	7.02	Yes	Yes	0	9	9
210	R:R:C251	R:R:W252	3.92	No	Yes	0	8	9
211	R:R:W252	R:R:Y256	9.65	Yes	Yes	0	9	8
212	R:R:A291	R:R:W252	5.19	No	Yes	0	8	9
213	R:R:H294	R:R:W252	15.87	Yes	Yes	0	9	9
214	R:R:P254	R:R:T287	5.25	No	No	0	9	6
215	R:R:Y255	R:R:Y256	5.96	Yes	Yes	1	7	8
216	R:R:I259	R:R:Y255	10.88	No	Yes	0	5	7
217	R:R:T287	R:R:Y255	3.75	No	Yes	0	6	7
218	R:R:E288	R:R:Y255	11.22	No	Yes	1	5	7
219	R:R:A291	R:R:Y255	4	No	Yes	0	8	7
220	R:R:G258	R:R:I284	3.53	No	No	0	4	4
221	R:R:I261	R:R:V280	6.14	No	No	0	5	5
222	R:R:D262	R:R:H281	8.82	No	No	0	5	4
223	R:R:D262	R:R:I284	4.2	No	No	0	5	4
224	R:R:F264	R:R:I269	5.02	No	No	0	4	1
225	R:R:E277	R:R:I265	5.47	No	No	0	2	3
226	R:R:I265	R:R:V280	4.61	No	No	0	3	5
227	R:R:E268	R:R:K271	5.4	No	No	0	2	3
228	R:R:F276	R:R:I270	3.77	Yes	No	0	1	5
229	R:R:F276	R:R:Q272	8.2	Yes	No	0	1	2
230	R:R:F276	R:R:V280	3.93	Yes	No	0	1	5
231	R:R:T287	R:R:W283	10.92	No	No	0	6	6
232	R:R:E288	R:R:F292	10.49	No	Yes	1	5	7
233	R:R:C296	R:R:F293	4.19	No	No	4	7	5
234	R:R:C295	R:R:H294	7.37	Yes	Yes	1	9	9
235	R:R:N298	R:R:Y302	3.49	Yes	Yes	1	9	9
236	R:R:A303	R:R:F309	8.32	No	Yes	2	7	8
237	R:R:F304	R:R:F309	5.36	Yes	Yes	0	6	8
238	R:R:H315	R:R:T311	5.48	No	No	0	4	4
239	R:R:C220	R:R:L216	3.17	No	No	0	3	4
240	R:R:I53	R:R:V88	3.07	No	Yes	0	5	6
241	R:R:I223	R:R:V242	3.07	No	No	0	4	4
242	R:R:K282	R:R:S285	3.06	No	No	0	2	5
243	R:R:I39	R:R:T43	3.04	No	No	0	5	4
244	R:R:I115	R:R:T90	3.04	No	No	0	5	6
245	R:R:I222	R:R:T241	3.04	No	No	0	8	7
246	R:R:F304	R:R:G55	3.01	Yes	No	0	6	8
247	R:R:F248	R:R:G212	3.01	Yes	No	7	9	6
248	R:R:F249	R:R:G212	3.01	No	No	7	4	6
249	R:R:L266	R:R:V196	2.98	No	No	0	3	4
250	R:R:L266	R:R:V197	2.98	No	No	0	3	3
251	R:R:L246	R:R:V242	2.98	No	No	0	5	4
252	R:R:L165	R:R:T168	2.95	No	No	0	3	6
253	R:R:I138	R:R:I222	2.94	No	No	0	8	8
254	R:R:I209	R:R:I213	2.94	No	No	0	4	3
255	R:R:K149	R:R:M72	2.88	No	No	0	6	6
256	R:R:I48	R:R:L91	2.85	No	No	0	7	8
257	R:R:I169	R:R:L166	2.85	No	No	0	3	4
258	R:R:I222	R:R:L226	2.85	No	No	0	8	8
259	R:R:I223	R:R:L238	2.85	No	No	0	4	5
260	R:R:K154	R:R:L150	2.82	No	No	0	3	4
261	R:R:K234	R:R:L226	2.82	No	No	0	7	8
262	R:R:L208	R:R:L253	2.77	No	No	0	8	5
263	R:R:L297	R:R:L301	2.77	No	Yes	0	6	7
264	R:R:D193	R:R:L266	2.71	No	No	0	1	3
265	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
266	R:R:A289	R:R:Y45	2.67	No	Yes	0	4	7
267	R:R:F276	R:R:T279	2.59	Yes	No	0	1	2
268	R:R:F304	R:R:I300	2.51	Yes	No	0	6	6
269	R:R:F40	R:R:L41	2.44	Yes	Yes	0	5	6
270	R:R:E179	R:R:Y184	2.24	No	No	0	2	5
271	R:R:R183	R:R:Y184	2.06	No	No	0	3	5
272	R:R:A128	R:R:P211	1.87	No	Yes	0	7	9
273	R:R:G159	R:R:V158	1.84	No	No	0	3	4
274	R:R:G57	R:R:I60	1.76	No	No	0	3	7
275	R:R:G258	R:R:I261	1.76	No	No	0	4	5
276	R:R:C218	R:R:S217	1.72	No	No	0	6	3
277	R:R:A100	R:R:V99	1.7	No	No	0	5	4
278	R:R:L290	R:R:P254	1.64	No	No	0	7	9
279	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
280	R:R:A180	R:R:I185	1.62	No	No	0	1	3
281	R:R:A111	R:R:L108	1.58	No	Yes	0	4	5
282	R:R:A237	R:R:L226	1.58	No	No	0	7	8
283	R:R:A247	R:R:L301	1.58	No	Yes	0	6	7
284	R:R:C274	R:R:N278	1.57	No	No	0	5	3
285	R:R:I60	R:R:V82	1.54	No	No	0	7	5
286	R:R:I47	R:R:T51	1.52	No	No	0	4	5
287	R:R:C274	R:R:E277	1.52	No	No	0	5	2
288	R:R:F104	R:R:G105	1.51	Yes	No	0	7	8
289	R:R:F129	R:R:G159	1.51	Yes	No	0	5	3
290	R:R:G64	R:R:R70	1.5	No	Yes	0	2	6
291	R:R:L86	R:R:S119	1.5	No	No	0	7	8
292	R:R:L238	R:R:S227	1.5	No	No	0	5	4
293	R:R:K239	R:R:T240	1.5	No	No	0	6	7
294	R:R:I204	R:R:I209	1.47	Yes	No	0	5	4
295	R:R:L244	R:R:T240	1.47	Yes	No	0	7	7
296	R:R:I257	R:R:I261	1.47	No	No	0	6	5
297	R:R:I269	R:R:I270	1.47	No	No	0	1	5
298	R:R:N143	R:R:T142	1.46	No	No	0	5	5
299	R:R:K308	R:R:K68	1.44	No	No	0	6	6
300	R:R:P147	R:R:R146	1.44	No	No	0	4	5
301	R:R:I53	R:R:L85	1.43	No	No	0	5	7
302	R:R:I89	R:R:L86	1.43	No	No	0	4	7
303	R:R:I243	R:R:L301	1.43	No	Yes	0	5	7
304	R:R:I300	R:R:L305	1.43	No	No	0	6	6
305	R:R:E153	R:R:K154	1.35	No	No	0	7	3
306	R:R:A316	R:R:Y65	1.33	No	No	0	5	5
307	R:R:A164	R:R:Y121	1.33	No	Yes	0	7	7
308	R:R:F199	R:R:V198	1.31	Yes	No	0	5	3
309	R:R:D187	R:R:H113	1.26	No	Yes	0	3	6
310	R:R:F49	R:R:L50	1.22	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F40	7.02	4	0	5
2	R:R:L41	4.2675	4	0	6
3	R:R:Y45	5.202	5	1	7
4	R:R:Q66	4.945	4	2	4
5	R:R:R70	4.168	5	2	6
6	R:R:D74	6.164	5	2	8
7	R:R:Y76	5.99	6	1	7
8	R:R:R77	5.885	4	2	8
9	R:R:H79	7.175	4	1	9
10	R:R:L80	5.416	5	1	9
11	R:R:D84	6.672	5	1	9
12	R:R:F87	7.55429	7	1	7
13	R:R:V88	3.525	4	0	6
14	R:R:F93	8.4275	4	3	6
15	R:R:W102	9.91333	6	3	9
16	R:R:F104	7.28	6	3	7
17	R:R:L108	5.19	4	3	5
18	R:R:H113	6.3125	4	0	6
19	R:R:Y116	5.158	5	1	6
20	R:R:L120	4.534	5	1	7
21	R:R:Y121	6.26333	6	1	7
22	R:R:F129	4.855	6	1	5
23	R:R:R134	6.8475	4	1	9
24	R:R:Y135	7.5775	4	6	8
25	R:R:R148	7.755	4	0	6
26	R:R:L151	4.295	4	1	4
27	R:R:V156	5.386	5	1	5
28	R:R:V160	5.24	5	1	7
29	R:R:D171	6.55	4	0	4
30	R:R:F174	7.0975	4	1	4
31	R:R:Y190	8.896	5	1	4
32	R:R:P191	4.9675	4	1	5
33	R:R:W195	7.2325	4	1	5
34	R:R:F199	5.54167	6	1	5
35	R:R:H203	7.2275	4	1	4
36	R:R:I204	3.9075	4	0	5
37	R:R:P211	3.4325	4	0	9
38	R:R:Y219	8.25	5	1	8
39	R:R:L244	3.962	5	1	7
40	R:R:F248	7.0725	4	7	9
41	R:R:W252	7.12714	7	0	9
42	R:R:Y255	6.51333	6	1	7
43	R:R:Y256	9.04	5	1	8
44	R:R:F276	4.6225	4	0	1
45	R:R:F292	9.7175	4	1	7
46	R:R:H294	8.9025	4	1	9
47	R:R:C295	5.61	4	1	9
48	R:R:N298	6.67	4	1	9
49	R:R:L301	2.4825	4	0	7
50	R:R:Y302	6.11	6	1	9
51	R:R:F304	3.6325	4	0	6
52	R:R:F309	7.282	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:L41	16.0531	2.44	Yes	Yes	0	5	6
2	R:R:L41	R:R:P42	11.0683	3.28	Yes	No	0	6	5
3	R:R:L41	R:R:Y45	32.2527	5.86	Yes	Yes	0	6	7
4	R:R:E288	R:R:Y45	10.7802	4.49	No	Yes	1	5	7
5	R:R:F292	R:R:Y45	29.3819	10.32	Yes	Yes	1	7	7
6	R:R:I48	R:R:L91	10.7363	2.85	No	No	0	7	8
7	R:R:F87	R:R:L91	12.8552	4.87	Yes	No	0	7	8
8	R:R:F292	R:R:F87	32.6677	13.93	Yes	Yes	1	7	7
9	R:R:C295	R:R:F87	75.7983	6.98	Yes	Yes	1	9	7
10	R:R:C295	R:R:V88	15.3745	3.42	Yes	Yes	0	9	6
11	R:R:C295	R:R:D84	100	4.67	Yes	Yes	1	9	9
12	R:R:D84	R:R:N56	94.6978	12.12	Yes	No	0	9	9
13	R:R:N56	R:R:P299	92.1199	13.03	No	No	0	9	9
14	R:R:G55	R:R:P299	89.5323	4.06	No	No	0	8	9
15	R:R:F304	R:R:G55	84.2886	3.01	Yes	No	0	6	8
16	R:R:F304	R:R:F309	73.8893	5.36	Yes	Yes	0	6	8
17	R:R:F309	R:R:V59	14.3785	5.24	Yes	No	2	8	8
18	R:R:S81	R:R:V59	11.8299	8.08	No	No	0	9	8
19	R:R:F309	R:R:V62	16.6683	7.87	Yes	No	0	8	7
20	R:R:S312	R:R:V62	11.3514	3.23	No	No	0	6	7
21	R:R:F309	R:R:R77	38.3752	9.62	Yes	Yes	2	8	8
22	R:R:M63	R:R:R77	10.8632	6.2	No	Yes	2	6	8
23	R:R:D74	R:R:R77	25.1196	3.57	Yes	Yes	2	8	8
24	R:R:K68	R:R:Q66	11.41	5.42	No	Yes	0	6	4
25	R:R:D84	R:R:L80	53.5006	4.07	Yes	Yes	1	9	9
26	R:R:L80	R:R:Y302	38.59	3.52	Yes	Yes	1	9	9
27	R:R:I130	R:R:Y302	24.8657	6.04	No	Yes	1	8	9
28	R:R:I130	R:R:Y76	28.1369	6.04	No	Yes	1	8	7
29	R:R:D133	R:R:Y76	33.1315	10.34	No	Yes	0	8	7
30	R:R:D133	R:R:R148	30.3095	14.29	No	Yes	0	8	6
31	R:R:M72	R:R:R148	18.2941	4.96	No	Yes	0	6	6
32	R:R:K75	R:R:M72	12.24	4.32	No	No	0	6	6
33	R:R:D84	R:R:N298	38.8634	8.08	Yes	Yes	1	9	9
34	R:R:N298	R:R:Y302	35.4165	3.49	Yes	Yes	1	9	9
35	R:R:F129	R:R:V160	20.208	6.55	Yes	Yes	1	5	7
36	R:R:I126	R:R:V160	11.1366	4.61	No	Yes	0	7	7
37	R:R:I126	R:R:L80	18.4064	5.71	No	Yes	0	7	9
38	R:R:V156	R:R:V160	11.5711	3.21	Yes	Yes	1	5	7
39	R:R:H294	R:R:S123	24.4214	5.58	Yes	No	0	9	9
40	R:R:F292	R:R:Y116	13.2995	4.13	Yes	Yes	1	7	6
41	R:R:F87	R:R:L120	31.9305	4.87	Yes	Yes	1	7	7
42	R:R:L120	R:R:Y116	23.9283	4.69	Yes	Yes	1	7	6
43	R:R:W94	R:R:Y116	48.9601	5.79	No	Yes	1	7	6
44	R:R:H113	R:R:W94	48.4718	9.52	Yes	No	0	6	7
45	R:R:A175	R:R:H113	36.0414	4.39	No	Yes	0	4	6
46	R:R:A175	R:R:K110	34.5816	3.21	No	No	0	4	7
47	R:R:K110	R:R:N106	31.535	5.6	No	No	5	7	3
48	R:R:N106	R:R:V177	30.1435	7.39	No	No	0	3	4
49	R:R:C186	R:R:V177	28.6447	6.83	No	No	0	9	4
50	R:R:C186	R:R:W102	25.5395	14.37	No	Yes	3	9	9
51	R:R:D97	R:R:W102	11.5125	3.35	No	Yes	0	5	9
52	R:R:D171	R:R:H113	14.9888	10.08	Yes	Yes	0	4	6
53	R:R:E288	R:R:Y255	25.5834	11.22	No	Yes	1	5	7
54	R:R:H203	R:R:Y255	18.8751	3.27	Yes	Yes	1	4	7
55	R:R:L120	R:R:Y121	29.9336	4.69	Yes	Yes	1	7	7
56	R:R:Y255	R:R:Y256	32.2137	5.96	Yes	Yes	1	7	8
57	R:R:W252	R:R:Y256	64.2857	9.65	Yes	Yes	0	9	8
58	R:R:A291	R:R:Y255	31.3495	4	No	Yes	0	8	7
59	R:R:A291	R:R:W252	32.3406	5.19	No	Yes	0	8	9
60	R:R:L120	R:R:W252	32.1844	4.56	Yes	Yes	0	7	9
61	R:R:H294	R:R:W252	56.8743	15.87	Yes	Yes	0	9	9
62	R:R:Q202	R:R:Y121	28.6203	3.38	No	Yes	1	3	7
63	R:R:V124	R:R:W252	38.8341	3.68	No	Yes	0	7	9
64	R:R:P211	R:R:V124	37.1643	5.3	Yes	No	0	9	7
65	R:R:L125	R:R:P211	31.8133	3.28	No	Yes	0	5	9
66	R:R:R134	R:R:Y302	17.1858	7.2	Yes	Yes	1	9	9
67	R:R:F248	R:R:W252	51.5868	7.02	Yes	Yes	0	9	9
68	R:R:F248	R:R:I215	43.985	7.54	Yes	No	0	9	7
69	R:R:I215	R:R:S131	42.613	7.74	No	No	0	7	9
70	R:R:C218	R:R:S131	25.0122	5.16	No	No	0	6	9
71	R:R:S131	R:R:Y219	40.1621	13.99	No	Yes	0	9	8
72	R:R:R134	R:R:Y219	22.4246	10.29	Yes	Yes	1	9	8
73	R:R:L244	R:R:Y302	31.5301	5.86	Yes	Yes	1	7	9
74	R:R:L244	R:R:Y219	23.3327	4.69	Yes	Yes	1	7	8
75	R:R:C218	R:R:Y135	20.0615	4.03	No	Yes	0	6	8
76	R:R:F199	R:R:Q202	28.0783	3.51	Yes	No	1	5	3
77	R:R:F201	R:R:S263	13.6705	6.61	No	No	0	4	5
78	R:R:Q200	R:R:S263	17.5276	10.11	No	No	0	5	5
79	R:R:I259	R:R:Q200	93.9557	5.49	No	No	0	5	5
80	R:R:I259	R:R:Y255	74.7437	10.88	No	Yes	0	5	7
81	R:R:F201	R:R:V197	10.0869	3.93	No	No	0	4	3
82	R:R:D262	R:R:Q200	76.0619	6.53	No	No	0	5	5
83	R:R:I204	R:R:Y256	32.0818	3.63	Yes	Yes	0	5	8
84	R:R:I204	R:R:I259	24.4166	5.89	Yes	No	0	5	5
85	R:R:T241	R:R:Y219	40.7724	6.24	No	Yes	0	7	8
86	R:R:I223	R:R:T241	15.9604	6.08	No	No	0	4	7
87	R:R:I222	R:R:T241	22.0486	3.04	No	No	0	8	7
88	R:R:I222	R:R:L226	15.9604	2.85	No	No	0	8	8
89	R:R:L244	R:R:T240	12.4207	1.47	Yes	No	0	7	7
90	R:R:T287	R:R:Y255	13.4704	3.75	No	Yes	0	6	7
91	R:R:D262	R:R:I284	68.1623	4.2	No	No	0	5	4
92	R:R:G258	R:R:I284	64.0758	3.53	No	No	0	4	4
93	R:R:G258	R:R:I261	59.8379	1.76	No	No	0	4	5
94	R:R:I261	R:R:V280	51.3231	6.14	No	No	0	5	5
95	R:R:F276	R:R:I270	13.0798	3.77	Yes	No	0	1	5
96	R:R:F276	R:R:V280	30.4023	3.93	Yes	No	0	1	5
97	R:R:E277	R:R:I265	13.0847	5.47	No	No	0	2	3
98	R:R:I265	R:R:V280	17.4202	4.61	No	No	0	3	5
99	R:R:E288	R:R:F292	14.8667	10.49	No	Yes	1	5	7
100	R:R:L125	R:R:V160	31.2128	4.47	No	Yes	0	5	7
101	R:R:H203	R:R:L120	16.9222	3.86	Yes	Yes	1	4	7
102	R:R:F87	R:R:Y116	25.6225	6.19	Yes	Yes	1	7	6
103	R:R:D84	R:R:S123	24.1236	4.42	Yes	No	0	9	9
104	R:R:C295	R:R:H294	27.8293	7.37	Yes	Yes	1	9	9
105	R:R:F129	R:R:Y76	10.8046	8.25	Yes	Yes	1	5	7
106	R:R:V156	R:R:Y76	10.5019	3.79	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8U4N_nogp

PDB Summary
PDB	8U4N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	264
Number of Links	310
Number of Hubs	52
Number of Links mediated by Hubs	181
Number of Communities	7
Number of Nodes involved in Communities	67
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	107
Number Of Links MetaPath	106
Number of Shortest Paths	68789
Length Of Smallest Path	3
Average Path Length	13.4347
Length of Longest Path	28
Minimum Path Strength	1.465
Average Path Strength	6.29582
Maximum Path Strength	17.205
Minimum Path Correlation	0.7
Average Path Correlation	0.922823
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.5813
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.7719
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • myosin binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • bioluminescence • metabolic process • generation of precursor metabolites and energy • head development • central nervous system development • brain development • nervous system development • cell adhesion • regulation of cell adhesion • apoptotic process • cell death • programmed cell death • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • chemotaxis • dendritic cell chemotaxis • response to external stimulus • leukocyte migration • dendritic cell migration • taxis • immune system process • mononuclear cell migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • neurogenesis • cellular developmental process • cell differentiation • regulation of response to external stimulus • regulation of chemotaxis • regulation of response to stimulus • regulation of locomotion • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • C-X-C chemokine receptor CXCR4 signaling pathway • calcium-mediated signaling • regulation of multicellular organismal development • regulation of developmental process • positive regulation of biological process • vasculature development • regulation of vasculature development • circulatory system development • positive regulation of developmental process • positive regulation of vasculature development • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • positive regulation of response to stimulus • macrophage migration inhibitory factor signaling pathway • positive regulation of cellular process • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of metabolic process • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • positive regulation of nervous system development • cell development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • cell surface • external side of plasma membrane • cell leading edge • anchoring junction • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • late endosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>8U4N_nogp_Chain_R F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V S L Y S S V L I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	doi.org/10.1016/j.celrep.2025.115255
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	Gi1/β1/γ2	2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		2.72	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ2	3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		3.29	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	Gi1/β1/γ2	3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.36	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.1	2024-03-13	doi.org/10.1101/2024.02.09.579708
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	doi.org/10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	doi.org/10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	doi.org/10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	doi.org/10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	doi.org/10.1126/science.1261064
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	doi.org/10.1016/j.celrep.2024.114578
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	-	-	3.01	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	-	-	3.2	2025-02-26	doi.org/10.1073/pnas.2425795122
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122

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