psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F21	R:R:F25	3.22	No	No	0	3	3
2	R:R:F25	R:R:V24	5.24	No	No	0	3	6
3	R:R:L33	R:R:V29	5.96	Yes	No	9	6	4
4	R:R:V29	R:R:W427	2.45	No	No	9	4	9
5	R:R:A30	R:R:G31	1.95	No	No	0	7	4
6	R:R:G31	R:R:S34	3.71	No	No	0	4	8
7	R:R:L33	R:R:S32	3	Yes	No	0	6	5
8	R:R:L33	R:R:W427	4.56	Yes	No	9	6	9
9	R:R:L33	R:R:Y430	10.55	Yes	Yes	9	6	9
10	R:R:L35	R:R:S34	7.51	No	No	0	6	8
11	R:R:M77	R:R:S34	3.07	No	No	0	9	8
12	R:R:G73	R:R:T37	1.82	Yes	No	0	8	8
13	R:R:T37	R:R:T434	10.99	No	Yes	0	8	7
14	R:R:G73	R:R:I38	1.76	Yes	No	0	8	7
15	R:R:I38	R:R:V74	9.22	No	No	0	7	5
16	R:R:G40	R:R:I39	3.53	No	No	15	9	5
17	R:R:I39	R:R:L43	2.85	No	No	15	5	8
18	R:R:G40	R:R:L43	6.84	No	No	15	9	8
19	R:R:I42	R:R:N41	4.25	No	Yes	0	6	9
20	R:R:M45	R:R:N41	5.61	No	Yes	0	7	9
21	R:R:D69	R:R:N41	2.69	Yes	Yes	0	9	9
22	R:R:L70	R:R:N41	17.85	No	Yes	0	8	9
23	R:R:I42	R:R:L43	2.85	No	No	0	6	8
24	R:R:F447	R:R:V44	6.55	Yes	No	0	9	9
25	R:R:F63	R:R:M45	9.95	No	No	16	7	7
26	R:R:C67	R:R:M45	3.24	No	No	16	7	7
27	R:R:V46	R:R:V50	8.02	No	No	0	6	7
28	R:R:F447	R:R:S47	6.61	Yes	No	0	9	9
29	R:R:I48	R:R:Y60	14.51	No	No	0	8	8
30	R:R:F63	R:R:I48	17.58	No	No	0	7	8
31	R:R:L54	R:R:N51	12.36	Yes	No	10	9	8
32	R:R:N51	R:R:T450	14.62	No	No	10	8	8
33	R:R:Q55	R:R:R52	2.34	No	No	0	8	8
34	R:R:L54	R:R:N444	4.12	Yes	Yes	10	9	9
35	R:R:L54	R:R:T446	11.79	Yes	No	10	9	7
36	R:R:F447	R:R:L54	6.09	Yes	Yes	10	9	9
37	R:R:L54	R:R:T450	11.79	Yes	No	10	9	8
38	R:R:Q55	R:R:Y60	10.15	No	No	0	8	8
39	R:R:N58	R:R:T56	2.92	Yes	No	0	9	8
40	R:R:R135	R:R:V57	11.77	No	No	0	8	7
41	R:R:T137	R:R:V57	3.17	No	No	0	5	7
42	R:R:D120	R:R:N58	2.69	No	Yes	5	9	9
43	R:R:N58	R:R:Y131	11.63	Yes	Yes	5	9	9
44	R:R:N58	R:R:R135	14.46	Yes	No	5	9	8
45	R:R:N58	V:V:D69	4.04	Yes	No	0	9	9
46	R:R:L62	R:R:N59	4.12	No	No	0	8	9
47	R:R:N444	R:R:N59	9.54	Yes	No	0	9	9
48	R:R:N59	V:V:D69	4.04	No	No	0	9	9
49	R:R:F61	R:R:I116	13.82	Yes	No	5	8	8
50	R:R:D120	R:R:F61	8.36	No	Yes	5	9	8
51	R:R:A140	R:R:F61	2.77	No	Yes	0	8	8
52	R:R:F61	R:R:M143	8.71	Yes	No	5	8	8
53	R:R:F61	R:R:I144	6.28	Yes	Yes	5	8	9
54	R:R:L62	R:R:Y440	9.38	No	Yes	0	8	9
55	R:R:C67	R:R:F63	4.19	No	No	16	7	7
56	R:R:N113	R:R:S64	4.47	Yes	No	5	9	9
57	R:R:I144	R:R:S64	9.29	Yes	No	5	9	9
58	R:R:D69	R:R:L65	8.14	Yes	No	0	9	9
59	R:R:L65	R:R:S110	3	No	No	0	9	9
60	R:R:L65	R:R:N436	6.87	No	Yes	0	9	9
61	R:R:A66	R:R:D69	4.63	No	Yes	0	9	9
62	R:R:C67	R:R:W148	5.22	No	No	0	7	9
63	R:R:A68	R:R:S110	1.71	No	No	0	9	9
64	R:R:A68	R:R:W148	5.19	No	No	0	9	9
65	R:R:D69	R:R:S433	5.89	Yes	No	0	9	9
66	R:R:D69	R:R:P437	12.88	Yes	No	0	9	9
67	R:R:L70	R:R:V74	7.45	No	No	0	8	5
68	R:R:I71	R:R:V106	6.14	No	No	0	8	7
69	R:R:G73	R:R:I72	3.53	Yes	No	0	8	8
70	R:R:I72	R:R:S76	3.1	No	No	0	8	8
71	R:R:I72	R:R:S433	9.29	No	No	0	8	9
72	R:R:G73	R:R:M77	6.99	Yes	No	0	8	9
73	R:R:F75	R:R:V74	3.93	No	No	0	5	5
74	R:R:D103	R:R:S76	2.94	Yes	No	0	9	8
75	R:R:M77	R:R:Y430	19.16	No	Yes	0	9	9
76	R:R:L79	R:R:N78	5.49	No	No	0	7	9
77	R:R:L82	R:R:N78	2.75	No	No	0	5	9
78	R:R:L79	R:R:W89	2.28	No	Yes	1	7	9
79	R:R:L79	R:R:W99	12.53	No	Yes	1	7	7
80	R:R:Y80	R:R:Y83	17.87	Yes	Yes	1	8	7
81	R:R:T84	R:R:Y80	8.74	No	Yes	1	7	8
82	R:R:W99	R:R:Y80	7.72	Yes	Yes	1	7	8
83	R:R:T423	R:R:Y80	12.48	No	Yes	1	6	8
84	R:R:Y426	R:R:Y80	20.85	Yes	Yes	1	7	8
85	R:R:Y80	W:W:?1	5.17	Yes	Yes	1	8	0
86	R:R:L82	R:R:W89	3.42	No	Yes	0	5	9
87	R:R:W89	R:R:Y83	35.69	Yes	Yes	1	9	7
88	R:R:W99	R:R:Y83	11.58	Yes	Yes	1	7	7
89	R:R:C176	R:R:Y83	10.75	No	Yes	1	9	7
90	R:R:Y83	W:W:?1	7.76	Yes	Yes	1	7	0
91	R:R:T423	R:R:T84	14.13	No	No	1	6	7
92	R:R:I86	R:R:P90	5.08	No	No	0	6	4
93	R:R:G174	R:R:Y88	5.79	No	No	0	3	4
94	R:R:P90	R:R:W89	4.05	No	Yes	0	4	9
95	R:R:L91	R:R:W89	22.78	No	Yes	1	8	9
96	R:R:V95	R:R:W89	2.45	Yes	Yes	1	6	9
97	R:R:C96	R:R:W89	5.22	No	Yes	1	9	9
98	R:R:W89	R:R:W99	3.75	Yes	Yes	1	9	7
99	R:R:D173	R:R:W89	2.23	No	Yes	1	3	9
100	R:R:C176	R:R:W89	9.14	No	Yes	1	9	9
101	R:R:L91	R:R:V95	17.88	No	Yes	1	8	6
102	R:R:G92	R:R:P93	4.06	No	No	1	7	4
103	R:R:G92	R:R:V95	1.84	No	Yes	1	7	6
104	R:R:D173	R:R:G92	6.71	No	No	1	3	7
105	R:R:P93	R:R:R169	2.88	No	No	1	4	8
106	R:R:D173	R:R:P93	6.44	No	No	1	3	4
107	R:R:C176	R:R:C96	5.46	No	No	1	9	9
108	R:R:D97	R:R:L160	8.14	No	No	0	7	6
109	R:R:L102	R:R:L98	6.92	No	No	0	6	6
110	R:R:L100	R:R:W99	4.56	Yes	Yes	1	7	7
111	R:R:D103	R:R:L100	6.79	Yes	Yes	1	9	7
112	R:R:L100	R:R:Y104	12.89	Yes	Yes	1	7	8
113	R:R:L100	R:R:Y426	4.69	Yes	Yes	1	7	7
114	R:R:D103	R:R:Y104	19.54	Yes	Yes	1	9	8
115	R:R:D103	R:R:Y426	11.49	Yes	Yes	1	9	7
116	R:R:W155	R:R:Y104	2.89	Yes	Yes	1	8	8
117	R:R:I178	R:R:Y104	7.25	Yes	Yes	1	7	8
118	R:R:Y104	R:R:Y403	12.91	Yes	No	0	8	8
119	R:R:Y104	R:R:Y426	6.95	Yes	Yes	1	8	7
120	R:R:F152	R:R:V105	15.73	No	No	0	5	8
121	R:R:S107	R:R:W400	8.65	No	Yes	0	8	9
122	R:R:N108	R:R:S151	5.96	No	No	0	9	9
123	R:R:N108	R:R:W155	23.73	No	Yes	1	9	8
124	R:R:A194	R:R:N108	3.13	No	No	1	8	9
125	R:R:A109	R:R:W148	3.89	No	No	0	8	9
126	R:R:A109	R:R:S151	3.42	No	No	0	8	9
127	R:R:P198	R:R:V111	1.77	No	No	0	9	9
128	R:R:F396	R:R:V111	9.18	No	No	13	9	9
129	R:R:V111	R:R:W400	3.68	No	Yes	13	9	9
130	R:R:A147	R:R:M112	3.22	No	No	0	8	8
131	R:R:M112	R:R:S151	3.07	No	No	0	8	9
132	R:R:I116	R:R:N113	9.91	No	Yes	5	8	9
133	R:R:I144	R:R:N113	2.83	Yes	Yes	5	9	9
134	R:R:A147	R:R:N113	3.13	No	Yes	0	8	9
135	R:R:I117	R:R:L114	7.14	No	No	0	9	9
136	R:R:L114	R:R:M202	5.65	No	Yes	0	9	9
137	R:R:F396	R:R:L114	8.53	No	No	0	9	9
138	R:R:F119	R:R:L115	12.18	No	No	18	7	7
139	R:R:I201	R:R:L115	5.71	No	No	18	7	7
140	R:R:I116	R:R:M143	10.2	No	No	5	8	8
141	R:R:M202	R:R:S118	9.2	Yes	No	0	9	9
142	R:R:S118	R:R:Y206	8.9	No	Yes	0	9	9
143	R:R:F119	R:R:I201	2.51	No	No	18	7	7
144	R:R:F119	R:R:L205	2.44	No	No	0	7	8
145	R:R:D120	R:R:Y131	17.24	No	Yes	5	9	9
146	R:R:R121	R:R:Y206	5.14	No	Yes	0	9	9
147	R:R:R121	V:V:D69	2.38	No	No	0	9	9
148	R:R:R121	V:V:L71	6.07	No	Yes	0	9	6
149	R:R:F123	R:R:Y122	5.16	No	No	0	6	9
150	R:R:T126	R:R:Y122	19.97	No	No	3	8	9
151	R:R:H208	R:R:Y122	7.62	No	No	3	6	9
152	R:R:F123	R:R:Y131	6.19	No	Yes	0	6	9
153	R:R:C124	V:V:V70	5.12	No	No	0	8	9
154	R:R:T126	R:R:V125	3.17	No	Yes	3	8	8
155	R:R:I209	R:R:V125	10.75	No	Yes	3	9	8
156	R:R:V125	V:V:L73	2.98	Yes	Yes	3	8	7
157	R:R:H208	R:R:T126	2.74	No	No	3	6	8
158	R:R:K127	R:R:T130	3	No	No	19	7	6
159	R:R:K127	V:V:Y249	5.97	No	Yes	19	7	8
160	R:R:L129	R:R:P128	4.93	No	No	0	7	9
161	R:R:L129	V:V:Y249	11.72	No	Yes	0	7	8
162	R:R:T130	V:V:Y249	4.99	No	Yes	19	6	8
163	R:R:P132	R:R:Y131	11.13	No	Yes	0	7	9
164	R:R:R135	R:R:Y131	12.35	No	Yes	5	8	9
165	R:R:P132	V:V:R65	2.88	No	Yes	0	7	8
166	R:R:M139	R:R:T136	3.01	No	No	0	8	9
167	R:R:M139	R:R:M142	4.33	No	No	0	8	4
168	R:R:A140	R:R:G141	1.95	No	No	0	8	4
169	R:R:G141	R:R:I144	3.53	No	Yes	0	4	9
170	R:R:L150	R:R:L154	2.77	No	No	0	6	8
171	R:R:A156	R:R:F152	8.32	No	No	0	6	5
172	R:R:L154	R:R:W155	7.97	No	Yes	0	8	8
173	R:R:T190	R:R:W155	10.92	No	Yes	0	9	8
174	R:R:A194	R:R:W155	2.59	No	Yes	1	8	8
175	R:R:A156	R:R:P157	1.87	No	No	0	6	8
176	R:R:F161	R:R:P157	2.89	No	No	0	7	8
177	R:R:I159	R:R:I178	2.94	Yes	Yes	1	8	7
178	R:R:I159	R:R:Q179	2.74	Yes	Yes	1	8	7
179	R:R:F180	R:R:I159	6.28	Yes	Yes	1	7	8
180	R:R:I165	R:R:W162	7.05	No	Yes	1	5	6
181	R:R:V166	R:R:W162	9.81	No	Yes	1	4	6
182	R:R:Q179	R:R:W162	8.76	Yes	Yes	1	7	6
183	R:R:F180	R:R:W162	20.04	Yes	Yes	1	7	6
184	R:R:N183	R:R:W162	20.34	No	Yes	0	7	6
185	R:R:Q163	R:R:R169	17.52	No	No	1	7	8
186	R:R:Q163	R:R:Q179	16.64	No	Yes	1	7	7
187	R:R:I165	R:R:V166	3.07	No	No	1	5	4
188	R:R:Q179	R:R:R169	14.02	Yes	No	1	7	8
189	R:R:T170	R:R:V171	3.17	No	No	1	5	4
190	R:R:Q179	R:R:T170	2.83	Yes	No	1	7	5
191	R:R:F181	R:R:T170	15.56	Yes	No	1	5	5
192	R:R:V171	R:R:Y177	18.93	No	Yes	1	4	4
193	R:R:F181	R:R:V171	10.49	Yes	No	1	5	4
194	R:R:E175	R:R:Y177	7.86	No	Yes	1	5	4
195	R:R:E175	R:R:N419	6.57	No	No	1	5	4
196	R:R:E175	W:W:?1	10.72	No	Yes	1	5	0
197	R:R:F181	R:R:Y177	10.32	Yes	Yes	1	5	4
198	R:R:Y177	W:W:?1	64.64	Yes	Yes	1	4	0
199	R:R:F180	R:R:I178	7.54	Yes	Yes	1	7	7
200	R:R:F181	R:R:I178	3.77	Yes	Yes	1	5	7
201	R:R:I178	W:W:?1	4.2	Yes	Yes	1	7	0
202	R:R:F180	R:R:T187	2.59	Yes	No	0	7	8
203	R:R:F181	R:R:S182	9.25	Yes	No	0	5	6
204	R:R:F181	R:R:N410	8.46	Yes	Yes	1	5	4
205	R:R:F181	W:W:?1	21.49	Yes	Yes	1	5	0
206	R:R:A185	R:R:N183	4.69	No	No	0	4	7
207	R:R:N183	R:R:V186	2.96	No	No	0	7	8
208	R:R:A184	R:R:T411	5.03	No	No	20	4	7
209	R:R:A184	R:R:F412	2.77	No	No	20	4	7
210	R:R:T190	R:R:V186	4.76	No	No	0	9	8
211	R:R:T187	R:R:V407	4.76	No	No	0	8	8
212	R:R:T187	R:R:T411	7.85	No	No	0	8	7
213	R:R:F188	R:R:G189	3.01	No	No	0	7	6
214	R:R:G189	R:R:I192	3.53	No	No	0	6	7
215	R:R:I192	R:R:Y196	6.04	No	No	0	7	8
216	R:R:F195	R:R:V199	3.93	Yes	No	0	9	7
217	R:R:F195	R:R:W400	3.01	Yes	Yes	0	9	9
218	R:R:A401	R:R:F195	2.77	No	Yes	0	7	9
219	R:R:F195	R:R:N404	20.54	Yes	No	0	9	7
220	R:R:I200	R:R:Y196	6.04	No	No	0	5	8
221	R:R:L393	R:R:M202	2.83	No	Yes	0	8	9
222	R:R:L393	R:R:T203	2.95	No	No	0	8	6
223	R:R:I209	R:R:Y206	2.42	No	Yes	0	9	9
224	R:R:I389	R:R:Y206	3.63	Yes	Yes	0	9	9
225	R:R:I392	R:R:Y206	6.04	No	Yes	0	9	9
226	R:R:S210	R:R:W207	7.41	No	No	0	8	4
227	R:R:I209	V:V:L73	2.85	No	Yes	3	9	7
228	R:R:E382	R:R:S213	4.31	No	No	3	9	8
229	R:R:S213	R:R:V385	6.46	No	Yes	3	8	8
230	R:R:S213	V:V:L73	3	No	Yes	3	8	7
231	R:R:E382	R:R:V385	2.85	No	Yes	3	9	8
232	R:R:E382	R:R:T386	9.88	No	No	0	9	8
233	R:R:I389	R:R:V385	3.07	Yes	Yes	0	9	8
234	R:R:V385	V:V:L71	2.98	Yes	Yes	3	8	6
235	R:R:V385	V:V:L73	5.96	Yes	Yes	3	8	7
236	R:R:C443	R:R:T388	5.07	No	No	3	9	9
237	R:R:T388	V:V:L71	4.42	No	Yes	3	9	6
238	R:R:C439	R:R:I392	3.27	No	No	17	9	9
239	R:R:I392	R:R:Y440	13.3	No	Yes	17	9	9
240	R:R:I397	R:R:L394	4.28	No	No	0	7	7
241	R:R:F396	R:R:W400	5.01	No	Yes	13	9	9
242	R:R:I398	R:R:T399	3.04	No	No	0	5	9
243	R:R:T399	R:R:W400	12.13	No	Yes	13	9	9
244	R:R:N432	R:R:T399	7.31	Yes	No	13	9	9
245	R:R:C429	R:R:W400	7.84	No	Yes	0	8	9
246	R:R:N432	R:R:W400	13.56	Yes	Yes	13	9	9
247	R:R:A401	R:R:P402	1.87	No	No	0	7	9
248	R:R:C429	R:R:P402	1.88	No	No	0	8	9
249	R:R:N404	R:R:V405	4.43	No	No	0	7	7
250	R:R:I417	R:R:M406	2.92	Yes	No	1	7	7
251	R:R:M406	R:R:W422	8.14	No	Yes	1	7	6
252	R:R:I409	R:R:L408	7.14	No	No	0	7	7
253	R:R:C413	R:R:I409	3.27	No	No	0	7	7
254	R:R:A414	R:R:N410	3.13	No	Yes	1	3	4
255	R:R:N410	R:R:W422	6.78	Yes	Yes	1	4	6
256	R:R:N410	W:W:?1	19.18	Yes	Yes	1	4	0
257	R:R:F412	R:R:T411	9.08	No	No	20	7	7
258	R:R:C413	R:R:C416	7.28	No	No	0	7	7
259	R:R:A414	R:R:P415	1.87	No	No	0	3	4
260	R:R:A414	W:W:?1	5.79	No	Yes	1	3	0
261	R:R:I417	R:R:P418	5.08	Yes	No	0	7	7
262	R:R:I417	R:R:W422	22.31	Yes	Yes	1	7	6
263	R:R:I417	W:W:?1	2.1	Yes	Yes	1	7	0
264	R:R:P418	R:R:V421	10.6	No	No	0	7	5
265	R:R:N419	R:R:T420	4.39	No	No	0	4	4
266	R:R:N419	W:W:?1	3.03	No	Yes	1	4	0
267	R:R:I424	R:R:V421	6.14	No	No	0	5	5
268	R:R:W422	W:W:?1	70.34	Yes	Yes	1	6	0
269	R:R:T423	W:W:?1	5.42	No	Yes	1	6	0
270	R:R:G425	R:R:I424	3.53	No	No	0	6	5
271	R:R:G425	R:R:L428	1.71	No	No	0	6	8
272	R:R:C429	R:R:G425	1.96	No	No	0	8	6
273	R:R:W427	R:R:Y430	8.68	No	Yes	9	9	9
274	R:R:I431	R:R:Y430	2.42	No	Yes	9	6	9
275	R:R:T434	R:R:Y430	3.75	Yes	Yes	9	7	9
276	R:R:I431	R:R:T434	3.04	No	Yes	9	6	7
277	R:R:N432	R:R:S433	4.47	Yes	No	0	9	9
278	R:R:N432	R:R:N436	4.09	Yes	Yes	0	9	9
279	R:R:N436	R:R:P437	3.26	Yes	No	0	9	9
280	R:R:N436	R:R:Y440	13.96	Yes	Yes	0	9	9
281	R:R:C439	R:R:Y440	8.06	No	Yes	17	9	9
282	R:R:A441	R:R:F447	2.77	No	Yes	0	8	9
283	R:R:C443	V:V:L71	6.35	No	Yes	3	9	6
284	R:R:N444	R:R:T446	5.85	Yes	No	10	9	7
285	R:R:F447	R:R:N444	10.87	Yes	Yes	10	9	9
286	R:R:F447	R:R:F451	9.65	Yes	No	0	9	9
287	R:R:K448	R:R:K449	12.93	No	No	0	9	6
288	R:R:F451	R:R:K448	7.44	No	No	0	9	9
289	R:R:E487	V:V:K160	4.05	No	No	0	3	8
290	V:V:G23	V:V:V8	3.68	No	No	0	8	7
291	V:V:F9	V:V:R25	8.55	No	Yes	0	5	9
292	V:V:K10	V:V:Y21	20.3	No	Yes	0	8	8
293	V:V:K11	V:V:V164	7.59	No	No	0	9	8
294	V:V:A12	V:V:T19	3.36	No	No	0	5	7
295	V:V:P14	V:V:S13	3.56	No	No	0	6	7
296	V:V:L18	V:V:S13	9.01	Yes	No	21	5	7
297	V:V:S13	V:V:V164	6.46	No	No	21	7	8
298	V:V:K17	V:V:N15	6.99	Yes	No	6	5	8
299	V:V:N15	V:V:Y47	17.44	No	Yes	6	8	5
300	V:V:N15	V:V:N162	2.72	No	Yes	6	8	8
301	V:V:G16	V:V:K17	1.74	No	Yes	0	5	5
302	V:V:D44	V:V:K17	4.15	Yes	Yes	6	8	5
303	V:V:K17	V:V:Y47	10.75	Yes	Yes	6	5	5
304	V:V:L18	V:V:V43	4.47	Yes	No	0	5	5
305	V:V:A148	V:V:L18	3.15	No	Yes	0	6	5
306	V:V:L18	V:V:V164	2.98	Yes	No	21	5	8
307	V:V:T19	V:V:Y21	8.74	No	Yes	0	7	8
308	V:V:L42	V:V:T19	4.42	No	No	0	6	7
309	V:V:F115	V:V:V20	2.62	Yes	No	0	9	7
310	V:V:L104	V:V:Y21	3.52	No	Yes	0	9	8
311	V:V:L108	V:V:Y21	9.38	Yes	Yes	0	8	8
312	V:V:G23	V:V:L22	1.71	No	No	0	8	8
313	V:V:G23	V:V:L100	1.71	No	No	0	8	6
314	V:V:D35	V:V:K24	4.15	No	No	0	6	7
315	V:V:L166	V:V:R25	4.86	No	Yes	0	9	9
316	V:V:I168	V:V:R25	2.51	No	Yes	0	8	9
317	V:V:L293	V:V:R25	6.07	Yes	Yes	0	8	9
318	V:V:D26	V:V:R169	8.34	No	No	0	9	9
319	V:V:D26	V:V:E359	7.8	No	No	0	9	1
320	V:V:D35	V:V:F27	4.78	No	No	0	6	8
321	V:V:F27	V:V:V37	10.49	No	No	0	8	8
322	V:V:F27	V:V:I168	6.28	No	No	0	8	8
323	V:V:H30	V:V:V28	2.77	No	No	0	6	7
324	V:V:V28	V:V:Y173	5.05	No	Yes	0	7	5
325	V:V:D29	V:V:V34	7.3	No	No	0	9	8
326	V:V:D29	V:V:K170	16.59	No	No	0	9	9
327	V:V:D29	V:V:Q172	9.14	No	No	0	9	9
328	V:V:H30	V:V:L33	11.57	No	No	0	6	3
329	V:V:D32	V:V:I31	7	No	No	0	4	5
330	V:V:I31	V:V:R307	5.01	No	No	0	5	5
331	V:V:D32	V:V:L33	2.71	No	No	0	4	3
332	V:V:I119	V:V:V34	7.68	No	No	0	5	8
333	V:V:D35	V:V:P36	9.66	No	No	0	6	4
334	V:V:F117	V:V:V37	3.93	Yes	No	0	8	8
335	V:V:D38	V:V:T98	5.78	No	No	7	7	7
336	V:V:D38	V:V:Q101	9.14	No	Yes	7	7	9
337	V:V:D38	V:V:T116	10.12	No	No	7	7	4
338	V:V:G39	V:V:V40	1.84	No	Yes	0	8	7
339	V:V:F115	V:V:G39	7.53	Yes	No	0	9	8
340	V:V:Q101	V:V:V40	2.87	Yes	Yes	7	9	7
341	V:V:L104	V:V:V40	2.98	No	Yes	0	9	7
342	V:V:P114	V:V:V40	1.77	No	Yes	7	8	7
343	V:V:S86	V:V:V41	3.23	No	No	0	5	5
344	V:V:F115	V:V:V41	5.24	Yes	No	0	9	5
345	V:V:L108	V:V:L42	2.77	Yes	No	0	8	6
346	V:V:A112	V:V:L42	3.15	No	No	0	7	6
347	V:V:L48	V:V:V43	2.98	Yes	No	0	5	5
348	V:V:D44	V:V:P45	4.83	Yes	No	0	8	5
349	V:V:D44	V:V:E46	6.5	Yes	No	0	8	4
350	V:V:D44	V:V:Y47	2.3	Yes	Yes	6	8	5
351	V:V:H111	V:V:P45	18.3	No	No	0	7	5
352	V:V:L48	V:V:Y47	4.69	Yes	Yes	6	5	5
353	V:V:R51	V:V:Y47	6.17	No	Yes	6	5	5
354	V:V:N162	V:V:Y47	3.49	Yes	Yes	6	8	5
355	V:V:L48	V:V:R51	6.07	Yes	No	6	5	5
356	V:V:L48	V:V:V53	2.98	Yes	Yes	0	5	7
357	V:V:E50	V:V:K49	6.75	No	No	0	4	4
358	V:V:E152	V:V:E50	2.54	No	No	0	4	4
359	V:V:R51	V:V:V150	14.38	No	No	0	5	6
360	V:V:R52	V:V:Y54	15.43	No	Yes	11	5	4
361	V:V:Q85	V:V:R52	12.85	No	No	11	9	5
362	V:V:P88	V:V:R52	24.5	No	No	11	9	5
363	V:V:S86	V:V:V53	8.08	No	Yes	0	5	7
364	V:V:F87	V:V:V53	2.62	Yes	Yes	0	4	7
365	V:V:V150	V:V:V53	4.81	No	Yes	0	6	7
366	V:V:Q85	V:V:Y54	3.38	No	Yes	11	9	4
367	V:V:F149	V:V:Y54	5.16	No	Yes	0	5	4
368	V:V:L154	V:V:Y54	9.38	No	Yes	0	3	4
369	V:V:V55	V:V:V84	3.21	No	No	22	7	3
370	V:V:F115	V:V:V55	7.87	Yes	No	0	9	7
371	V:V:F117	V:V:V55	6.55	Yes	No	22	8	7
372	V:V:N83	V:V:T56	7.31	No	Yes	0	5	6
373	V:V:K147	V:V:T56	3	No	Yes	0	7	6
374	V:V:F149	V:V:T56	5.19	No	Yes	0	5	6
375	V:V:F80	V:V:L57	2.44	No	No	0	4	7
376	V:V:F117	V:V:L57	6.09	Yes	No	0	8	7
377	V:V:L57	V:V:V146	2.98	No	No	0	7	7
378	V:V:T58	V:V:V81	4.76	No	No	0	7	4
379	V:V:E145	V:V:T58	5.64	No	No	0	7	7
380	V:V:L79	V:V:V59	5.96	No	No	0	7	8
381	V:V:V59	V:V:Y144	16.4	No	Yes	0	8	7
382	V:V:A60	V:V:R76	6.91	No	Yes	0	8	9
383	V:V:F61	V:V:L79	2.44	No	No	0	9	7
384	V:V:F61	V:V:G141	3.01	No	No	0	9	9
385	V:V:F61	V:V:I317	5.02	No	No	0	9	8
386	V:V:E66	V:V:R62	5.82	No	Yes	24	7	8
387	V:V:R62	V:V:R76	8.53	Yes	Yes	0	8	9
388	V:V:K138	V:V:R62	16.09	No	Yes	24	8	8
389	V:V:D143	V:V:R62	2.38	No	Yes	0	8	8
390	V:V:F75	V:V:Y63	11.35	Yes	No	0	9	9
391	V:V:L243	V:V:Y63	3.52	No	No	0	8	9
392	V:V:G64	V:V:L68	3.42	No	Yes	4	9	8
393	V:V:F75	V:V:G64	4.52	Yes	No	4	9	9
394	V:V:G64	V:V:L140	1.71	No	No	4	9	9
395	V:V:D67	V:V:R65	8.34	No	Yes	4	9	8
396	V:V:L68	V:V:R65	2.43	Yes	Yes	4	8	8
397	V:V:D135	V:V:R65	7.15	No	Yes	4	8	8
398	V:V:R285	V:V:R65	4.26	Yes	Yes	4	7	8
399	V:V:E66	V:V:K138	10.8	No	No	24	7	8
400	V:V:D67	V:V:L68	6.79	No	Yes	4	9	8
401	V:V:F75	V:V:L68	17.05	Yes	Yes	4	9	8
402	V:V:L73	V:V:V70	5.96	Yes	No	0	7	9
403	V:V:F75	V:V:V70	5.24	Yes	No	0	9	9
404	V:V:G72	V:V:L71	1.71	No	Yes	0	9	6
405	V:V:D78	V:V:R76	4.76	No	Yes	0	9	9
406	V:V:E145	V:V:R76	2.33	No	Yes	0	7	9
407	V:V:K77	V:V:L243	5.64	No	No	0	9	8
408	V:V:D78	V:V:V81	4.38	No	No	0	9	4
409	V:V:G316	V:V:L79	1.71	No	No	0	9	7
410	V:V:A82	V:V:F80	2.77	No	No	0	4	4
411	V:V:F80	V:V:P120	17.34	No	Yes	0	4	6
412	V:V:F117	V:V:V84	6.55	Yes	No	22	8	3
413	V:V:A90	V:V:Q85	3.03	Yes	No	0	1	9
414	V:V:F87	V:V:P88	7.22	Yes	No	11	4	9
415	V:V:F87	V:V:P89	7.22	Yes	No	11	4	3
416	V:V:F87	V:V:Y113	6.19	Yes	No	0	4	3
417	V:V:P88	V:V:P89	1.95	No	No	11	9	3
418	V:V:A90	V:V:P91	1.87	Yes	No	0	1	3
419	V:V:A90	V:V:D93	4.63	Yes	No	0	1	3
420	V:V:D93	V:V:K95	13.83	No	No	0	3	2
421	V:V:K95	V:V:P96	3.35	No	No	0	2	3
422	V:V:L97	V:V:Q101	7.99	No	Yes	7	3	9
423	V:V:L97	V:V:P114	4.93	No	No	7	3	8
424	V:V:L100	V:V:T98	2.95	No	No	0	6	7
425	V:V:Q101	V:V:T98	9.92	Yes	No	7	9	7
426	V:V:L100	V:V:L104	2.77	No	No	0	6	9
427	V:V:P114	V:V:Q101	7.9	No	Yes	7	8	9
428	V:V:Q101	V:V:T116	5.67	Yes	No	7	9	4
429	V:V:K107	V:V:L108	5.64	No	Yes	0	9	8
430	V:V:G109	V:V:L108	1.71	No	Yes	0	9	8
431	V:V:H111	V:V:Y113	2.18	No	No	0	7	3
432	V:V:I119	V:V:P120	3.39	No	Yes	0	5	6
433	V:V:P120	V:V:P121	1.95	Yes	No	0	6	4
434	V:V:L123	V:V:P120	6.57	No	Yes	0	6	6
435	V:V:N122	V:V:P121	3.26	No	No	0	6	4
436	V:V:L123	V:V:P124	4.93	No	Yes	23	6	9
437	V:V:L123	V:V:Y144	3.52	No	Yes	23	6	7
438	V:V:P124	V:V:Y144	4.17	Yes	Yes	23	9	7
439	V:V:L315	V:V:P124	4.93	No	Yes	0	5	9
440	V:V:G316	V:V:P124	2.03	No	Yes	0	9	9
441	V:V:S126	V:V:Y144	6.36	No	Yes	0	9	7
442	V:V:R169	V:V:S126	2.64	No	No	0	9	9
443	V:V:I317	V:V:V127	4.61	No	No	0	8	8
444	V:V:G291	V:V:T128	5.46	No	No	25	9	6
445	V:V:K292	V:V:T128	4.5	Yes	No	25	6	6
446	V:V:L129	V:V:L140	2.77	No	No	4	7	9
447	V:V:G141	V:V:L129	1.71	No	No	4	9	7
448	V:V:P131	V:V:Q130	3.16	No	No	0	8	9
449	V:V:Q130	V:V:R282	2.34	No	No	0	9	6
450	V:V:L287	V:V:Q130	5.32	No	No	0	7	9
451	V:V:G132	V:V:P133	4.06	No	No	4	5	5
452	V:V:G132	V:V:R285	7.51	No	Yes	4	5	7
453	V:V:P133	V:V:R285	4.32	No	Yes	4	5	7
454	V:V:D135	V:V:R285	7.15	No	Yes	4	8	7
455	V:V:G137	V:V:T136	5.46	No	No	0	8	4
456	V:V:G141	V:V:L140	1.71	No	No	4	9	9
457	V:V:V142	V:V:Y144	2.52	No	Yes	0	9	7
458	V:V:D143	V:V:E145	10.39	No	No	0	8	7
459	V:V:K170	V:V:Y144	2.39	No	Yes	0	9	7
460	V:V:I158	V:V:K147	2.91	No	No	0	5	7
461	V:V:K147	V:V:R165	11.14	No	No	0	7	6
462	V:V:F149	V:V:S163	5.28	No	No	0	5	7
463	V:V:N162	V:V:V150	4.43	Yes	No	0	8	6
464	V:V:A151	V:V:E156	3.02	No	No	0	6	6
465	V:V:H159	V:V:K157	2.62	No	No	0	4	5
466	V:V:H159	V:V:N162	5.1	No	Yes	0	4	8
467	V:V:N162	V:V:R161	3.62	Yes	No	0	8	8
468	V:V:L293	V:V:V167	4.47	Yes	No	0	8	5
469	V:V:L293	V:V:R169	7.29	Yes	No	0	8	9
470	V:V:V171	V:V:Y173	2.52	No	Yes	0	6	5
471	V:V:M352	V:V:Q172	2.72	Yes	No	0	8	9
472	V:V:K355	V:V:Y173	5.97	No	Yes	0	7	5
473	V:V:P356	V:V:Y173	12.52	No	Yes	0	8	5
474	V:V:A174	V:V:P175	1.87	No	No	0	9	9
475	V:V:A174	V:V:Y209	2.67	No	No	0	9	7
476	V:V:I207	V:V:P175	6.77	No	No	0	5	9
477	V:V:L305	V:V:P175	6.57	No	No	0	5	9
478	V:V:P178	V:V:R177	2.88	No	No	0	4	3
479	V:V:G179	V:V:P180	4.06	No	No	0	5	4
480	V:V:E206	V:V:G179	6.55	Yes	No	0	7	5
481	V:V:P182	V:V:Q181	3.16	No	No	0	9	6
482	V:V:L203	V:V:P182	8.21	Yes	No	0	8	9
483	V:V:E206	V:V:P182	3.14	Yes	No	0	7	9
484	V:V:S202	V:V:T183	3.2	No	No	0	7	4
485	V:V:E185	V:V:H198	4.92	No	No	0	5	5
486	V:V:L199	V:V:T186	4.42	Yes	No	14	6	6
487	V:V:T186	V:V:V345	3.17	No	No	14	6	7
488	V:V:P196	V:V:T187	3.5	No	No	0	6	6
489	V:V:H198	V:V:T187	5.48	No	No	0	5	6
490	V:V:F190	V:V:R188	2.14	No	No	0	9	7
491	V:V:L197	V:V:R188	2.43	No	No	0	7	7
492	V:V:R188	V:V:V343	9.15	No	No	0	7	7
493	V:V:D194	V:V:Q189	7.83	No	No	27	6	6
494	V:V:P196	V:V:Q189	23.69	No	No	27	6	6
495	V:V:K226	V:V:M192	2.88	Yes	No	0	8	7
496	V:V:D194	V:V:P196	4.83	No	No	27	6	6
497	V:V:K195	V:V:N223	4.2	No	No	0	7	6
498	V:V:K195	V:V:T224	3	No	No	0	7	8
499	V:V:K226	V:V:L197	11.28	Yes	No	0	8	7
500	V:V:H198	V:V:T221	5.48	No	Yes	0	5	6
501	V:V:L199	V:V:V220	4.47	Yes	No	0	6	7
502	V:V:L199	V:V:L327	8.3	Yes	Yes	14	6	7
503	V:V:L199	V:V:V343	2.98	Yes	No	14	6	7
504	V:V:L199	V:V:V345	4.47	Yes	No	14	6	7
505	V:V:E200	V:V:H219	6.15	No	Yes	0	7	5
506	V:V:N217	V:V:S202	5.96	No	No	0	6	7
507	V:V:L203	V:V:V216	2.98	Yes	No	0	8	6
508	V:V:L203	V:V:V323	4.47	Yes	No	26	8	6
509	V:V:L203	V:V:L347	5.54	Yes	No	26	8	5
510	V:V:D204	V:V:K205	13.83	No	No	2	7	8
511	V:V:D204	V:V:Y208	4.6	No	Yes	2	7	7
512	V:V:D204	V:V:S215	4.42	No	No	0	7	4
513	V:V:K205	V:V:Y208	10.75	No	Yes	2	8	7
514	V:V:E212	V:V:K205	5.4	No	No	2	7	8
515	V:V:E206	V:V:I207	6.83	Yes	No	2	7	5
516	V:V:E206	V:V:T350	4.23	Yes	Yes	2	7	4
517	V:V:I207	V:V:T350	4.56	No	Yes	2	5	4
518	V:V:E212	V:V:Y208	6.73	No	Yes	2	7	7
519	V:V:I214	V:V:Y208	9.67	Yes	Yes	2	8	7
520	V:V:F349	V:V:Y208	3.09	Yes	Yes	2	7	7
521	V:V:P354	V:V:Y209	11.13	No	No	0	8	7
522	V:V:H210	V:V:N299	2.55	Yes	Yes	2	9	8
523	V:V:H210	V:V:S302	4.18	Yes	No	0	9	9
524	V:V:H210	V:V:L351	9	Yes	No	2	9	9
525	V:V:H210	V:V:H353	15.53	Yes	No	2	9	8
526	V:V:E212	V:V:P213	12.58	No	No	0	7	4
527	V:V:P213	V:V:T273	1.75	No	No	0	4	4
528	V:V:P213	V:V:T275	1.75	No	No	0	4	5
529	V:V:I214	V:V:L274	2.85	Yes	No	0	8	5
530	V:V:I214	V:V:P276	5.08	Yes	No	0	8	9
531	V:V:F349	V:V:I214	3.77	Yes	Yes	2	7	8
532	V:V:S215	V:V:T273	3.2	No	No	0	4	4
533	V:V:I233	V:V:V216	3.07	Yes	No	0	5	6
534	V:V:N217	V:V:V271	2.96	No	No	0	6	5
535	V:V:V218	V:V:Y272	2.52	No	Yes	0	7	4
536	V:V:V218	V:V:V325	3.21	No	No	0	7	8
537	V:V:H219	V:V:T221	4.11	Yes	Yes	28	5	6
538	V:V:H219	V:V:T267	6.85	Yes	No	28	5	6
539	V:V:H219	V:V:S269	9.76	Yes	No	0	5	6
540	V:V:F268	V:V:V220	3.93	Yes	No	0	5	7
541	V:V:N223	V:V:T221	5.85	No	Yes	0	6	6
542	V:V:T221	V:V:T267	6.28	Yes	No	28	6	6
543	V:V:K226	V:V:N222	8.39	Yes	No	0	8	9
544	V:V:N222	V:V:V262	4.43	No	No	0	9	7
545	V:V:N222	V:V:P264	4.89	No	Yes	0	9	5
546	V:V:K226	V:V:T224	6.01	Yes	No	0	8	8
547	V:V:N225	V:V:P264	9.77	No	Yes	0	5	5
548	V:V:K226	V:V:V329	6.07	Yes	No	0	8	6
549	V:V:P264	V:V:T227	5.25	Yes	No	0	5	5
550	V:V:V228	V:V:V262	3.21	No	No	0	8	7
551	V:V:L327	V:V:V228	2.98	Yes	No	0	7	8
552	V:V:V228	V:V:V329	4.81	No	No	0	8	6
553	V:V:K229	V:V:L338	7.05	No	No	0	8	4
554	V:V:D259	V:V:K230	11.06	No	No	0	4	6
555	V:V:D260	V:V:I231	2.8	Yes	No	0	6	6
556	V:V:I231	V:V:L327	4.28	No	Yes	0	6	7
557	V:V:K232	V:V:M255	4.32	No	No	0	6	3
558	V:V:E257	V:V:K232	2.7	No	No	0	7	6
559	V:V:K232	V:V:K326	7.18	No	Yes	0	6	6
560	V:V:E256	V:V:I233	8.2	No	Yes	8	4	5
561	V:V:I233	V:V:Y272	3.63	Yes	Yes	8	5	4
562	V:V:I233	V:V:V325	4.61	Yes	No	0	5	8
563	V:V:R236	V:V:S234	3.95	Yes	No	12	5	5
564	V:V:M255	V:V:S234	3.07	No	No	0	3	5
565	V:V:K324	V:V:S234	4.59	No	No	12	6	5
566	V:V:L274	V:V:V235	4.47	No	No	0	5	7
567	V:V:F349	V:V:V235	2.62	Yes	No	0	7	7
568	V:V:R236	V:V:Y238	18.52	Yes	Yes	12	5	5
569	V:V:K250	V:V:R236	6.19	No	Yes	12	5	5
570	V:V:K324	V:V:R236	4.95	No	Yes	12	6	5
571	V:V:Q237	V:V:V253	4.3	Yes	No	0	9	9
572	V:V:L287	V:V:Q237	3.99	No	Yes	0	7	9
573	V:V:A288	V:V:Q237	3.03	No	Yes	0	9	9
574	V:V:Q237	V:V:V319	4.3	Yes	No	2	9	9
575	V:V:Q237	V:V:Y321	16.91	Yes	Yes	2	9	9
576	V:V:Q248	V:V:Y238	4.51	No	Yes	12	7	5
577	V:V:K250	V:V:Y238	5.97	No	Yes	12	5	5
578	V:V:K322	V:V:Y238	14.33	No	Yes	0	6	5
579	V:V:E346	V:V:Y238	11.22	No	Yes	0	8	5
580	V:V:D240	V:V:Q248	14.36	No	No	0	7	7
581	V:V:I241	V:V:Y249	3.63	No	Yes	0	8	8
582	V:V:G316	V:V:V242	1.84	No	No	0	9	8
583	V:V:L243	V:V:N245	5.49	No	No	0	8	8
584	V:V:K250	V:V:Q248	14.92	No	No	12	5	7
585	V:V:P252	V:V:V251	3.53	No	No	30	4	6
586	V:V:K284	V:V:V251	3.04	Yes	No	30	8	6
587	V:V:M255	V:V:P252	3.35	No	No	0	3	4
588	V:V:K284	V:V:P252	5.02	Yes	No	30	8	4
589	V:V:P276	V:V:V253	1.77	No	No	0	9	9
590	V:V:N281	V:V:V253	2.96	No	No	0	9	9
591	V:V:E256	V:V:Y272	4.49	No	Yes	8	4	4
592	V:V:A258	V:V:D260	4.63	No	Yes	8	5	6
593	V:V:A258	V:V:Y272	4	No	Yes	8	5	4
594	V:V:D259	V:V:T261	5.78	No	No	0	4	5
595	V:V:D260	V:V:F268	4.78	Yes	Yes	8	6	5
596	V:V:D260	V:V:K270	5.53	Yes	No	8	6	7
597	V:V:D260	V:V:Y272	8.05	Yes	Yes	8	6	4
598	V:V:F268	V:V:V262	3.93	Yes	No	0	5	7
599	V:V:A263	V:V:P264	1.87	No	Yes	0	4	5
600	V:V:A263	V:V:S266	3.42	No	No	0	4	7
601	V:V:F268	V:V:K270	7.44	Yes	No	8	5	7
602	V:V:F268	V:V:Y272	2.06	Yes	Yes	8	5	4
603	V:V:K270	V:V:Y272	29.86	No	Yes	8	7	4
604	V:V:P276	V:V:T275	1.75	No	No	0	9	5
605	V:V:F277	V:V:T275	3.89	No	No	0	4	5
606	V:V:A279	V:V:F277	2.77	No	No	0	4	4
607	V:V:F277	V:V:N280	14.5	No	No	0	4	4
608	V:V:L278	V:V:R282	6.07	No	No	0	8	6
609	V:V:L278	V:V:L289	4.15	No	No	0	8	9
610	V:V:L278	V:V:L300	5.54	No	No	0	8	9
611	V:V:N280	V:V:N281	10.9	No	No	0	4	9
612	V:V:K284	V:V:N281	2.8	Yes	No	0	8	9
613	V:V:E283	V:V:K284	5.4	No	Yes	0	5	8
614	V:V:L287	V:V:L300	2.77	No	No	0	7	9
615	V:V:A288	V:V:A301	1.79	No	No	0	9	9
616	V:V:K292	V:V:L289	2.82	Yes	No	0	6	9
617	V:V:D290	V:V:N299	5.39	No	Yes	0	9	8
618	V:V:D290	V:V:S302	5.89	No	No	0	9	9
619	V:V:G291	V:V:K292	1.74	No	Yes	25	9	6
620	V:V:K292	V:V:T298	10.51	Yes	No	0	6	8
621	V:V:E296	V:V:L293	7.95	No	Yes	0	7	8
622	V:V:E296	V:V:K294	2.7	No	No	0	7	9
623	V:V:E296	V:V:H362	22.16	No	No	0	7	1
624	V:V:N299	V:V:T298	4.39	Yes	No	0	8	8
625	V:V:H353	V:V:N299	8.93	No	Yes	2	8	8
626	V:V:S303	V:V:Y321	2.54	No	Yes	2	8	9
627	V:V:S303	V:V:T350	6.4	No	Yes	2	8	4
628	V:V:M352	V:V:S303	3.07	Yes	No	2	8	8
629	V:V:L305	V:V:M352	4.24	No	Yes	0	5	8
630	V:V:E308	V:V:R307	8.14	No	No	0	4	5
631	V:V:E308	V:V:G309	6.55	No	No	0	4	4
632	V:V:E313	V:V:N311	14.46	No	No	0	7	4
633	V:V:I314	V:V:N311	5.66	No	No	0	6	4
634	V:V:I318	V:V:L315	5.71	No	No	0	6	5
635	V:V:V319	V:V:Y321	5.05	No	Yes	2	9	9
636	V:V:F349	V:V:Y321	5.16	Yes	Yes	2	7	9
637	V:V:L351	V:V:Y321	2.34	No	Yes	2	9	9
638	V:V:K322	V:V:P348	5.02	No	No	0	6	9
639	V:V:L347	V:V:V323	4.47	No	No	26	5	6
640	V:V:E346	V:V:K324	16.2	No	No	0	8	6
641	V:V:K326	V:V:V328	3.04	Yes	No	29	6	4
642	V:V:D342	V:V:K326	9.68	No	Yes	29	7	6
643	V:V:A344	V:V:K326	3.21	No	Yes	0	4	6
644	V:V:L327	V:V:V343	4.47	Yes	No	14	7	7
645	V:V:D342	V:V:V328	5.84	No	No	29	7	4
646	V:V:G332	V:V:S330	1.86	No	No	0	5	6
647	V:V:G336	V:V:R331	6	No	No	0	5	5
648	V:V:R331	V:V:S340	3.95	No	No	0	5	4
649	V:V:G332	V:V:G333	2.11	No	No	0	5	8
650	V:V:G332	V:V:G336	2.11	No	No	0	5	5
651	V:V:F349	V:V:L351	2.44	Yes	No	2	7	9
652	V:V:M352	V:V:T350	4.52	Yes	Yes	2	8	4
653	V:V:H353	V:V:P354	4.58	No	No	0	8	8
654	V:V:K355	V:V:K357	2.87	No	No	0	7	1
655	V:V:E359	V:V:P360	9.43	No	No	0	1	1
656	V:V:P360	V:V:P361	1.95	No	No	0	1	1
657	V:V:P361	V:V:R363	5.76	No	No	0	1	1
658	R:R:A68	R:R:V106	1.7	No	No	0	9	7
659	R:R:A212	R:R:V125	1.7	No	Yes	0	7	8
660	R:R:A146	R:R:V149	1.7	No	No	0	4	5
661	R:R:A191	R:R:V407	1.7	No	No	0	8	8
662	V:V:A184	V:V:V345	1.7	No	No	0	6	7
663	V:V:A201	V:V:V218	1.7	No	No	0	7	7
664	V:V:A254	V:V:V235	1.7	No	No	0	8	7
665	R:R:A30	R:R:T81	1.68	No	No	0	7	7
666	R:R:L197	R:R:P198	1.64	No	No	0	7	9
667	V:V:S265	V:V:S266	1.63	No	No	0	7	7
668	R:R:S47	R:R:V46	1.62	No	No	0	9	6
669	R:R:A101	R:R:I159	1.62	No	Yes	0	8	8
670	R:R:A395	R:R:I435	1.62	No	No	0	8	6
671	V:V:A112	V:V:I105	1.62	No	No	0	7	4
672	V:V:S125	V:V:V127	1.62	No	No	0	7	8
673	V:V:S340	V:V:V329	1.62	No	No	0	4	6
674	R:R:K127	V:V:A247	1.61	No	No	0	7	8
675	R:R:V23	R:R:V27	1.6	No	No	0	4	5
676	R:R:V94	R:R:V95	1.6	No	Yes	0	4	6
677	V:V:S125	V:V:T304	1.6	No	No	0	7	9
678	R:R:T20	R:R:V23	1.59	No	No	0	5	4
679	R:R:T434	R:R:V36	1.59	Yes	No	0	7	5
680	R:R:T81	R:R:V85	1.59	No	No	0	7	6
681	R:R:T203	R:R:V204	1.59	No	No	0	6	5
682	R:R:C443	R:R:L442	1.59	No	No	0	9	7
683	R:R:T136	R:R:T137	1.57	No	No	0	9	5
684	V:V:T56	V:V:T58	1.57	Yes	No	0	6	7
685	V:V:E134	V:V:P133	1.57	No	No	0	4	5
686	V:V:A310	V:V:N122	1.56	No	No	0	4	6
687	V:V:A247	V:V:N245	1.56	No	No	0	8	8
688	R:R:I389	R:R:S210	1.55	Yes	No	0	9	8
689	V:V:I318	V:V:S320	1.55	No	No	0	6	8
690	R:R:I26	R:R:V27	1.54	No	No	0	6	5
691	R:R:I397	R:R:V199	1.54	No	No	0	7	7
692	V:V:M192	V:V:S193	1.53	No	No	0	7	8
693	R:R:K49	R:R:V46	1.52	No	No	0	5	6
694	V:V:K230	V:V:V328	1.52	No	No	0	6	4
695	V:V:A239	V:V:Q237	1.52	No	Yes	0	8	9
696	V:V:A90	V:V:E92	1.51	Yes	No	0	1	3
697	R:R:L28	R:R:S32	1.5	No	No	0	4	5
698	R:R:K138	R:R:T136	1.5	No	No	0	5	9
699	R:R:K384	R:R:T388	1.5	No	No	0	9	9
700	V:V:G286	V:V:R285	1.5	No	Yes	0	9	7
701	R:R:L102	R:R:V106	1.49	No	No	0	6	7
702	R:R:L408	R:R:V405	1.49	No	No	0	7	7
703	V:V:N217	V:V:S269	1.49	No	No	0	6	6
704	R:R:I200	R:R:I201	1.47	No	No	0	5	7
705	V:V:L306	V:V:T304	1.47	No	No	0	4	9
706	V:V:D290	V:V:V171	1.46	No	No	0	9	6
707	R:R:G87	R:R:Y88	1.45	No	No	0	6	4
708	R:R:K134	R:R:M139	1.44	No	No	0	6	8
709	V:V:K229	V:V:K230	1.44	No	No	0	8	6
710	R:R:I389	R:R:L390	1.43	Yes	No	0	9	7
711	R:R:L115	R:R:M202	1.41	No	Yes	0	7	9
712	R:R:P90	R:R:Y88	1.39	No	No	0	4	4
713	V:V:A339	V:V:R331	1.38	No	No	0	4	5
714	V:V:L154	V:V:N153	1.37	No	No	0	3	4
715	R:R:D97	R:R:L98	1.36	No	No	0	7	6
716	V:V:E176	V:V:K355	1.35	No	No	0	3	7
717	R:R:V133	V:V:R285	1.31	No	Yes	0	5	7
718	V:V:E155	V:V:N153	1.31	No	No	0	4	4
719	V:V:E156	V:V:N153	1.31	No	No	0	6	4
720	R:R:F21	R:R:T20	1.3	No	No	0	3	5
721	V:V:R76	V:V:T74	1.29	Yes	No	0	9	7
722	R:R:H53	R:R:N51	1.28	No	No	0	6	8
723	V:V:E152	V:V:E156	1.27	No	No	0	4	6
724	V:V:I318	V:V:R312	1.25	No	No	0	6	6
725	R:R:V105	R:R:W155	1.23	No	Yes	0	8	8
726	V:V:D297	V:V:R282	1.19	No	No	0	9	6
727	R:R:E22	R:R:F21	1.17	No	No	0	5	3
728	R:R:F164	R:R:Q163	1.17	No	No	0	6	7
729	R:R:H208	R:R:R211	1.13	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L33	6.0175	4	9	6
2	R:R:N41	7.6	4	0	9
3	R:R:L54	9.23	5	10	9
4	R:R:N58	7.148	5	5	9
5	R:R:F61	7.988	5	5	8
6	R:R:D69	6.846	5	0	9
7	R:R:G73	3.525	4	0	8
8	R:R:Y80	12.1383	6	1	8
9	R:R:Y83	16.73	5	1	7
10	R:R:W89	9.101	10	1	9
11	R:R:V95	5.9425	4	1	6
12	R:R:W99	8.028	5	1	7
13	R:R:L100	7.2325	4	1	7
14	R:R:D103	10.19	4	1	9
15	R:R:Y104	10.405	6	1	8
16	R:R:N113	5.085	4	5	9
17	R:R:V125	4.65	4	3	8
18	R:R:Y131	11.708	5	5	9
19	R:R:I144	5.4825	4	5	9
20	R:R:W155	8.22167	6	1	8
21	R:R:I159	3.395	4	1	8
22	R:R:W162	13.2	5	1	6
23	R:R:Y177	25.4375	4	1	4
24	R:R:I178	5.14	5	1	7
25	R:R:Q179	8.998	5	1	7
26	R:R:F180	9.1125	4	1	7
27	R:R:F181	11.3343	7	1	5
28	R:R:F195	7.5625	4	0	9
29	R:R:M202	4.7725	4	0	9
30	R:R:Y206	5.226	5	0	9
31	R:R:V385	4.264	5	3	8
32	R:R:I389	2.42	4	0	9
33	R:R:W400	7.69714	7	13	9
34	R:R:N410	9.3875	4	1	4
35	R:R:I417	8.1025	4	1	7
36	R:R:W422	26.8925	4	1	6
37	R:R:Y426	10.995	4	1	7
38	R:R:Y430	8.912	5	9	9
39	R:R:N432	7.3575	4	13	9
40	R:R:T434	4.8425	4	9	7
41	R:R:N436	7.045	4	0	9
42	R:R:Y440	11.175	4	17	9
43	R:R:N444	7.595	4	10	9
44	R:R:F447	7.09	6	10	9
45	V:V:K17	5.9075	4	6	5
46	V:V:L18	4.9025	4	21	5
47	V:V:Y21	10.485	4	0	8
48	V:V:R25	5.4975	4	0	9
49	V:V:V40	2.365	4	7	7
50	V:V:D44	4.445	4	6	8
51	V:V:Y47	7.47333	6	6	5
52	V:V:L48	4.18	4	6	5
53	V:V:V53	4.6225	4	0	7
54	V:V:Y54	8.3375	4	11	4
55	V:V:T56	4.2675	4	0	6
56	V:V:R62	8.205	4	24	8
57	V:V:R65	5.012	5	4	8
58	V:V:L68	7.4225	4	4	8
59	V:V:L71	4.306	5	3	6
60	V:V:L73	4.15	5	3	7
61	V:V:F75	9.54	4	4	9
62	V:V:R76	4.764	5	0	9
63	V:V:F87	5.8125	4	11	4
64	V:V:A90	2.76	4	0	1
65	V:V:Q101	7.24833	6	7	9
66	V:V:L108	4.875	4	0	8
67	V:V:F115	5.815	4	0	9
68	V:V:F117	5.78	4	22	8
69	V:V:P120	7.3125	4	0	6
70	V:V:P124	4.015	4	23	9
71	V:V:Y144	5.89333	6	23	7
72	V:V:N162	3.872	5	6	8
73	V:V:Y173	6.515	4	0	5
74	V:V:L199	4.928	5	14	6
75	V:V:L203	5.3	4	26	8
76	V:V:E206	5.1875	4	2	7
77	V:V:Y208	6.968	5	2	7
78	V:V:H210	7.815	4	2	9
79	V:V:I214	5.3425	4	2	8
80	V:V:H219	6.7175	4	28	5
81	V:V:T221	5.43	4	28	6
82	V:V:K226	6.926	5	0	8
83	V:V:I233	4.8775	4	8	5
84	V:V:R236	8.4025	4	12	5
85	V:V:Q237	5.675	6	2	9
86	V:V:Y238	10.91	5	12	5
87	V:V:Y249	6.5775	4	19	8
88	V:V:D260	5.158	5	8	6
89	V:V:P264	5.445	4	0	5
90	V:V:F268	4.428	5	8	5
91	V:V:Y272	7.80143	7	8	4
92	V:V:K284	4.065	4	30	8
93	V:V:R285	4.34167	6	4	7
94	V:V:K292	4.8925	4	25	6
95	V:V:L293	6.445	4	0	8
96	V:V:N299	5.315	4	2	8
97	V:V:Y321	6.4	5	2	9
98	V:V:K326	5.7775	4	29	6
99	V:V:L327	5.0075	4	14	7
100	V:V:F349	3.416	5	2	7
101	V:V:T350	4.9275	4	2	4
102	V:V:M352	3.6375	4	2	8
103	W:W:?1	18.32	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I72	R:R:S433	29.2958	9.29	No	No	0	8	9
2	R:R:N436	R:R:Y440	47.598	13.96	Yes	Yes	0	9	9
3	R:R:N432	R:R:N436	34.5469	4.09	Yes	Yes	0	9	9
4	R:R:N432	R:R:S433	28.948	4.47	Yes	No	0	9	9
5	R:R:D120	R:R:F61	33.1505	8.36	No	Yes	5	9	8
6	R:R:I116	R:R:N113	15.5727	9.91	No	Yes	5	8	9
7	R:R:A147	R:R:N113	30.7524	3.13	No	Yes	0	8	9
8	R:R:A147	R:R:M112	30.2512	3.22	No	No	0	8	8
9	R:R:M112	R:R:S151	29.7573	3.07	No	No	0	8	9
10	R:R:N108	R:R:S151	29.1836	5.96	No	No	0	9	9
11	R:R:N108	R:R:W155	28.0646	23.73	No	Yes	1	9	8
12	R:R:W155	R:R:Y104	21.0749	2.89	Yes	Yes	1	8	8
13	R:R:D103	R:R:Y104	11.4726	19.54	Yes	Yes	1	9	8
14	R:R:D103	R:R:S76	23.2945	2.94	Yes	No	0	9	8
15	R:R:I72	R:R:S76	23.5667	3.1	No	No	0	8	8
16	R:R:I144	R:R:N113	15.636	2.83	Yes	Yes	5	9	9
17	R:R:I178	R:R:Y104	27.4492	7.25	Yes	Yes	1	7	8
18	R:R:M202	R:R:S118	11.6177	9.2	Yes	No	0	9	9
19	R:R:I392	R:R:Y440	44.5794	13.3	No	Yes	17	9	9
20	R:R:I392	R:R:Y206	45.0491	6.04	No	Yes	0	9	9
21	R:R:S118	R:R:Y206	11.9053	8.9	No	Yes	0	9	9
22	R:R:I209	R:R:Y206	54.8207	2.42	No	Yes	0	9	9
23	V:V:L73	V:V:V70	60.0317	5.96	Yes	No	0	7	9
24	R:R:I209	V:V:L73	54.2018	2.85	No	Yes	3	9	7
25	V:V:F75	V:V:V70	60.2509	5.24	Yes	No	0	9	9
26	R:R:P132	R:R:Y131	38.7952	11.13	No	Yes	0	7	9
27	R:R:P132	V:V:R65	38.8539	2.88	No	Yes	0	7	8
28	V:V:F75	V:V:G64	60.9496	4.52	Yes	No	4	9	9
29	V:V:G64	V:V:L140	99.8657	1.71	No	No	4	9	9
30	V:V:G141	V:V:L140	99.6671	1.71	No	No	4	9	9
31	V:V:F61	V:V:G141	99.9197	3.01	No	No	0	9	9
32	V:V:F61	V:V:L79	100	2.44	No	No	0	9	7
33	V:V:L79	V:V:V59	73.3421	5.96	No	No	0	7	8
34	V:V:V59	V:V:Y144	73.2907	16.4	No	Yes	0	8	7
35	V:V:L123	V:V:Y144	25.562	3.52	No	Yes	23	6	7
36	V:V:L123	V:V:P120	50.6028	6.57	No	Yes	0	6	6
37	V:V:F80	V:V:P120	59.618	17.34	No	Yes	0	4	6
38	V:V:F80	V:V:L57	58.6168	2.44	No	No	0	4	7
39	V:V:F117	V:V:L57	57.6217	6.09	Yes	No	0	8	7
40	V:V:F117	V:V:V55	56.5886	6.55	Yes	No	22	8	7
41	V:V:F115	V:V:V55	56.1245	7.87	Yes	No	0	9	7
42	V:V:F115	V:V:G39	16.3085	7.53	Yes	No	0	9	8
43	V:V:G39	V:V:V40	15.7178	1.84	No	Yes	0	8	7
44	V:V:L104	V:V:V40	10.9359	2.98	No	Yes	0	9	7
45	V:V:G316	V:V:L79	26.6692	1.71	No	No	0	9	7
46	V:V:G316	V:V:P124	26.5725	2.03	No	Yes	0	9	9
47	V:V:L123	V:V:P124	25.5373	4.93	No	Yes	23	6	9
48	V:V:F115	V:V:V41	40.7334	5.24	Yes	No	0	9	5
49	V:V:S86	V:V:V41	40.187	3.23	No	No	0	5	5
50	V:V:S86	V:V:V53	39.6395	8.08	No	Yes	0	5	7
51	V:V:K170	V:V:Y144	46.2649	2.39	No	Yes	0	9	7
52	V:V:D29	V:V:K170	46.073	16.59	No	No	0	9	9
53	V:V:D29	V:V:Q172	57.1936	9.14	No	No	0	9	9
54	V:V:M352	V:V:Q172	56.992	2.72	Yes	No	0	8	9
55	V:V:M352	V:V:S303	32.8783	3.07	Yes	No	2	8	8
56	V:V:S303	V:V:Y321	36.8689	2.54	No	Yes	2	8	9
57	V:V:L351	V:V:Y321	14.0539	2.34	No	Yes	2	9	9
58	V:V:H210	V:V:L351	14.0971	9	Yes	No	2	9	9
59	V:V:D290	V:V:V171	10.5377	1.46	No	No	0	9	6
60	V:V:D29	V:V:V34	11.7942	7.3	No	No	0	9	8
61	V:V:I119	V:V:P120	11.9413	3.39	No	Yes	0	5	6
62	V:V:F87	V:V:V53	26.1495	2.62	Yes	Yes	0	4	7
63	V:V:F87	V:V:P88	23.3161	7.22	Yes	No	11	4	9
64	V:V:P88	V:V:R52	22.7574	24.5	No	No	11	9	5
65	V:V:R52	V:V:Y54	17.9817	15.43	No	Yes	11	5	4
66	V:V:F149	V:V:Y54	12.7599	5.16	No	Yes	0	5	4
67	V:V:F149	V:V:T56	11.5642	5.19	No	Yes	0	5	6
68	V:V:Q237	V:V:Y321	17.6508	16.91	Yes	Yes	2	9	9
69	V:V:M352	V:V:T350	22.5732	4.52	Yes	Yes	2	8	4
70	V:V:E206	V:V:T350	26.1032	4.23	Yes	Yes	2	7	4
71	V:V:E206	V:V:P182	25.3906	3.14	Yes	No	0	7	9
72	V:V:L203	V:V:P182	24.7352	8.21	Yes	No	0	8	9
73	V:V:L203	V:V:V216	23.7442	2.98	Yes	No	0	8	6
74	V:V:I233	V:V:V216	23.4118	3.07	Yes	No	0	5	6
75	V:V:I233	V:V:Y272	21.6424	3.63	Yes	Yes	8	5	4
76	V:V:F268	V:V:Y272	17.7548	2.06	Yes	Yes	8	5	4
77	V:V:F268	V:V:V262	14.5478	3.93	Yes	No	0	5	7
78	V:V:N222	V:V:V262	10.8644	4.43	No	No	0	9	7
79	V:V:Q237	V:V:V253	13.6623	4.3	Yes	No	0	9	9
80	V:V:N281	V:V:V253	12.1512	2.96	No	No	0	9	9
81	V:V:K284	V:V:N281	10.8186	2.8	Yes	No	0	8	9
82	R:R:F61	R:R:I116	15.7369	13.82	Yes	No	5	8	8
83	R:R:F61	R:R:I144	16.362	6.28	Yes	Yes	5	8	9
84	V:V:L68	V:V:R65	39.2984	2.43	Yes	Yes	4	8	8
85	V:V:G64	V:V:L68	38.8955	3.42	No	Yes	4	9	8
86	R:R:D120	R:R:Y131	31.4675	17.24	No	Yes	5	9	9
87	V:V:I119	V:V:V34	11.5235	7.68	No	No	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y80	R:R:Y83	17.87	1	Yes	Yes	8	7	1	1
R:R:T84	R:R:Y80	8.74	1	No	Yes	7	8	2	1
R:R:W99	R:R:Y80	7.72	1	Yes	Yes	7	8	2	1
R:R:T423	R:R:Y80	12.48	1	No	Yes	6	8	1	1
R:R:Y426	R:R:Y80	20.85	1	Yes	Yes	7	8	2	1
R:R:Y80	W:W:?1	5.17	1	Yes	Yes	8	0	1	0
R:R:W89	R:R:Y83	35.69	1	Yes	Yes	9	7	2	1
R:R:W99	R:R:Y83	11.58	1	Yes	Yes	7	7	2	1
R:R:C176	R:R:Y83	10.75	1	No	Yes	9	7	2	1
R:R:Y83	W:W:?1	7.76	1	Yes	Yes	7	0	1	0
R:R:T423	R:R:T84	14.13	1	No	No	6	7	1	2
R:R:W89	R:R:W99	3.75	1	Yes	Yes	9	7	2	2
R:R:C176	R:R:W89	9.14	1	No	Yes	9	9	2	2
R:R:I178	R:R:Y104	7.25	1	Yes	Yes	7	8	1	2
R:R:Y104	R:R:Y426	6.95	1	Yes	Yes	8	7	2	2
R:R:I159	R:R:I178	2.94	1	Yes	Yes	8	7	2	1
R:R:F180	R:R:I159	6.28	1	Yes	Yes	7	8	2	2
R:R:T170	R:R:V171	3.17	1	No	No	5	4	2	2
R:R:F181	R:R:T170	15.56	1	Yes	No	5	5	1	2
R:R:V171	R:R:Y177	18.93	1	No	Yes	4	4	2	1
R:R:F181	R:R:V171	10.49	1	Yes	No	5	4	1	2
R:R:E175	R:R:Y177	7.86	1	No	Yes	5	4	1	1
R:R:E175	R:R:N419	6.57	1	No	No	5	4	1	1
R:R:E175	W:W:?1	10.72	1	No	Yes	5	0	1	0
R:R:F181	R:R:Y177	10.32	1	Yes	Yes	5	4	1	1
R:R:Y177	W:W:?1	64.64	1	Yes	Yes	4	0	1	0
R:R:F180	R:R:I178	7.54	1	Yes	Yes	7	7	2	1
R:R:F181	R:R:I178	3.77	1	Yes	Yes	5	7	1	1
R:R:I178	W:W:?1	4.2	1	Yes	Yes	7	0	1	0
R:R:F181	R:R:S182	9.25	1	Yes	No	5	6	1	2
R:R:F181	R:R:N410	8.46	1	Yes	Yes	5	4	1	1
R:R:F181	W:W:?1	21.49	1	Yes	Yes	5	0	1	0
R:R:I417	R:R:M406	2.92	1	Yes	No	7	7	1	2
R:R:M406	R:R:W422	8.14	1	No	Yes	7	6	2	1
R:R:A414	R:R:N410	3.13	1	No	Yes	3	4	1	1
R:R:N410	R:R:W422	6.78	1	Yes	Yes	4	6	1	1
R:R:N410	W:W:?1	19.18	1	Yes	Yes	4	0	1	0
R:R:A414	R:R:P415	1.87	1	No	No	3	4	1	2
R:R:A414	W:W:?1	5.79	1	No	Yes	3	0	1	0
R:R:I417	R:R:P418	5.08	1	Yes	No	7	7	1	2
R:R:I417	R:R:W422	22.31	1	Yes	Yes	7	6	1	1
R:R:I417	W:W:?1	2.1	1	Yes	Yes	7	0	1	0
R:R:N419	R:R:T420	4.39	1	No	No	4	4	1	2
R:R:N419	W:W:?1	3.03	1	No	Yes	4	0	1	0
R:R:W422	W:W:?1	70.34	1	Yes	Yes	6	0	1	0
R:R:T423	W:W:?1	5.42	1	No	Yes	6	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
81.82	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
72.73	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
64.29	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
63.64	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
63.64	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
61.54	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
61.54	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
61.54	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
61.54	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
61.54	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
60.00	Single	6OS2	TRV026	6OS2-AT₁-TRV026
60.00	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
60.00	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
60.00	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
58.33	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
55.56	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
54.55	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
53.85	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
53.33	Single	6OS1	TRV026	6OS1-AT₁-TRV026
52.94	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
50.00	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
50.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
50.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
47.62	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
47.37	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
47.37	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
47.37	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
47.06	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
47.06	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
47.06	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
46.67	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
46.67	Consensus	dp_off	Orthosteric Ligand	dp2_off
46.15	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
46.15	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
45.45	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
45.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
45.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
45.00	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
45.00	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
44.44	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
44.44	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.44	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.75	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.75	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
42.86	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
42.86	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
42.86	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
42.86	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
42.86	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
42.86	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
42.86	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
42.11	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
42.11	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
42.11	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
42.11	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
41.67	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
41.67	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
41.67	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
41.18	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
41.18	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
41.18	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
41.18	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
40.91	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
40.91	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
40.91	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
40.91	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
40.00	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
40.00	Single	6D27	CAY10471	6D27-DP₂-CAY10471
40.00	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
40.00	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
40.00	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
40.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
40.00	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
40.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
40.00	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.00	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
40.00	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
40.00	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
40.00	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
40.00	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
39.13	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
39.13	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
39.13	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
39.13	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
39.13	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
38.89	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
38.89	Single	7EZC	UKA	7EZC-A_2A-UKA
38.89	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
38.89	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
38.89	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.89	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
38.89	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
38.89	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
38.89	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
38.89	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
38.89	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
38.89	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
38.89	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
38.46	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
38.46	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
38.46	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
38.46	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
38.46	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
38.10	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
38.10	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
38.10	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
38.10	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
38.10	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
38.10	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
38.10	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.10	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
38.10	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
38.10	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
38.10	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
37.50	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
37.50	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
37.50	Single	5N2S	PSB36	5N2S-A₁-PSB36
37.50	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
37.50	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
37.50	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
37.50	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
37.50	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
37.50	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
37.50	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
37.50	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
37.50	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
37.50	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
37.50	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
37.50	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
37.50	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
37.50	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
37.50	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
37.50	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
37.50	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
37.50	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
36.84	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
36.84	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
36.84	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
36.84	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
36.84	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
36.84	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
36.84	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
36.84	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
36.84	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Single	7V68	LY2119620	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
36.36	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
36.36	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
36.36	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
36.36	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
36.36	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.36	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
36.36	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
36.36	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
36.36	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
36.00	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
36.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
36.00	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
35.71	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
35.71	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
35.71	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
35.71	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
35.71	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
35.71	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
35.71	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
35.71	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
35.71	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
35.71	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
35.71	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
35.71	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
35.71	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
35.71	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.29	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
35.29	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
35.29	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
35.29	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
35.29	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
35.29	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
35.29	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
35.29	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
35.29	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
35.29	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
35.29	Single	9UY3	Anamorelin	9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.29	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
35.29	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
35.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
35.00	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
35.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
35.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
35.00	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
35.00	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
35.00	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
35.00	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
35.00	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
35.00	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
35.00	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
34.78	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
34.78	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
34.78	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
34.78	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
34.78	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
34.78	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
34.78	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
34.62	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
34.62	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
34.62	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
34.62	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
34.62	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
33.33	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
33.33	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
33.33	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
33.33	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
33.33	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
33.33	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
33.33	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
33.33	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
33.33	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
33.33	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
33.33	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
33.33	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
33.33	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
33.33	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
33.33	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
33.33	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
33.33	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
33.33	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
33.33	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
33.33	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
33.33	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
33.33	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
33.33	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
33.33	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
33.33	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
33.33	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
33.33	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
33.33	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
33.33	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
33.33	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
33.33	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
33.33	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
33.33	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
33.33	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
33.33	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
33.33	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
33.33	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
33.33	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
33.33	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
33.33	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
33.33	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
33.33	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
33.33	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
33.33	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
33.33	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
33.33	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
33.33	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
33.33	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
33.33	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
33.33	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
33.33	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
33.33	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
33.33	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
33.33	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
33.33	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
33.33	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
33.33	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
33.33	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.14	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
32.00	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
31.82	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
31.82	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
31.82	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
31.82	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
31.82	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
31.82	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
31.82	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
31.82	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
31.58	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
31.58	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
31.58	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
31.58	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
31.58	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
31.58	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
31.58	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
31.58	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
31.58	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
31.25	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
31.25	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
31.25	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
31.25	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
31.25	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
31.25	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
31.25	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
31.25	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
31.25	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
31.25	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
31.25	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.25	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
31.25	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
31.25	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.25	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.25	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
31.25	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
31.25	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
31.25	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
31.25	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
31.25	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
31.25	Single	9H37	A1IR0	9H37-A_2A-A1IR0-Na
31.25	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
31.25	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.25	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
31.25	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
31.03	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
30.77	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
30.77	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
30.77	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
30.77	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
30.77	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
30.77	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
30.77	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
30.77	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
30.77	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
30.77	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
30.43	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.43	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
30.43	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.43	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
30.00	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.00	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
30.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
30.00	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
30.00	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
30.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
30.00	Single	8XQJ	JN241	8XQJ-Apelin-JN241
30.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
30.00	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
30.00	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
30.00	Single	9M0R	Neuropeptide VF	9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
30.00	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
30.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
29.63	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
29.41	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
29.41	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
29.41	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
29.41	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
29.41	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
29.41	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
29.41	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
29.41	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
29.41	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
29.41	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
29.41	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
29.41	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.41	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
29.17	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
29.17	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.17	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
29.17	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
28.57	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
28.57	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
28.57	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
28.57	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
28.57	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
28.57	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
28.57	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.57	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
28.57	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
28.57	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
28.57	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
28.57	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
28.57	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
28.57	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
28.57	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
28.57	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.57	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
28.57	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
28.57	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
28.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
28.00	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.00	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
28.00	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
28.00	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
27.78	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
27.78	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
27.78	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
27.78	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
27.78	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
27.78	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
27.78	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
27.78	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
27.78	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
27.78	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
27.78	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
27.78	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
27.78	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
27.78	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
27.78	Single	8ZWF	JR14a	8ZWF-C3a_B-JR14a
27.78	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
27.78	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
27.59	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
27.27	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
27.27	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
27.27	Single	9E82	SDF-1-beta	9E82-ACKR3-SDF-1-β-Arrestin2
27.27	Single	9IK8	SST analogue	9IK8-SST1-SST analogue-Gi1/β1/γ2
27.27	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
27.27	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
26.92	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
26.92	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
26.92	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
26.92	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
26.67	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
26.67	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
26.67	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
26.67	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
26.67	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
26.67	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
26.67	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
26.67	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
26.67	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
26.67	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
26.67	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
26.67	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
26.67	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
26.67	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
26.67	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
26.67	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
26.67	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
26.67	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
26.67	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
26.32	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
26.32	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
26.32	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
26.32	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
26.32	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
26.32	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
26.32	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
26.32	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
26.32	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
26.32	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
26.32	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
26.32	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
26.32	Single	8XQJ	JN241	8XQJ-Apelin-JN241
26.09	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
26.09	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
26.09	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
26.09	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
26.09	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.09	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
25.93	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
25.93	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
25.93	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
25.00	Single	3REY	XAC	3REY-A_2A-XAC
25.00	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
25.00	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
25.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
25.00	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
25.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
25.00	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
25.00	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
25.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
25.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
25.00	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.00	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
25.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
25.00	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
25.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
25.00	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
25.00	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
25.00	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
25.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
25.00	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
25.00	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
25.00	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
25.00	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
25.00	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
25.00	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
25.00	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.00	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
25.00	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
25.00	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
25.00	Single	9JH3	CMF-019	9JH3-Apelin-CMF-019-Gi1/β1/γ2
25.00	Single	9M54	Neuropeptide VF	9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
25.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
25.00	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
25.00	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
25.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
25.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
25.00	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.00	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
25.00	Consensus	hca_on	Orthosteric Ligand	hca2_on
25.00	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
24.14	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
24.14	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
24.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
24.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
24.00	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
24.00	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
24.00	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
24.00	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.00	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
24.00	Consensus	pac_on	Orthosteric Ligand	pac1_on
23.81	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
23.81	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
23.81	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
23.81	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
23.81	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
23.81	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
23.81	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.81	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
23.81	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
23.81	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
23.81	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
23.53	Single	5UEN	DU172	5UEN-A₁-DU172
23.53	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
23.53	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
23.53	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
23.53	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
23.53	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
23.53	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
23.53	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
23.53	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
23.53	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
23.53	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
23.53	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
23.53	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
23.53	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
23.53	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
23.53	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.53	Single	8ZYY	Neurotensin peptide 8-13	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
23.53	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
23.53	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
23.53	Consensus	a3_on	Orthosteric Ligand	a3a_on
23.53	Consensus	cck_off	Orthosteric Ligand	ccka_off
23.53	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
23.53	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
23.53	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
23.53	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
23.53	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
23.08	Single	6FJ3	PTH	6FJ3-PTH1-PTH
23.08	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
23.08	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
23.08	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
23.08	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
23.08	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
23.08	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
22.73	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
22.73	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.73	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
22.73	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
22.73	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
22.73	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
22.22	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
22.22	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.22	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
22.22	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
22.22	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
22.22	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
22.22	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
22.22	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
22.22	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
22.22	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.22	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
22.22	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
22.22	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
22.22	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.22	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.74	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
21.74	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
21.74	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
21.43	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.43	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
21.43	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
21.43	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
21.43	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.05	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
21.05	Single	5V56	TC114	5V56-SMO-TC114
21.05	Single	5V57	TC114	5V57-SMO-TC114
21.05	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
21.05	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
21.05	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
21.05	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
21.05	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.05	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.05	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
21.05	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
21.05	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
21.05	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
21.05	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
21.05	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
21.05	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
21.05	Single	9IK9	SST analogue	9IK9-SST1-SST analogue-Gi1/β1/γ2
21.05	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	9JMC	DS-3801b	9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
21.05	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
21.05	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
20.83	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
20.83	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
20.83	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
20.83	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
20.83	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
20.83	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.69	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
20.69	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.69	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.69	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
20.69	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
20.69	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
20.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
20.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
20.00	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
20.00	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
20.00	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
20.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
20.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
20.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.00	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
20.00	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
20.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
20.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
20.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
20.00	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
20.00	Single	8JWY	2-118	8JWY-A_2A-2-118
20.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
20.00	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
20.00	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
20.00	Single	8ZYU	Neurotensin peptide 8-13	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.00	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
20.00	Single	9M4Q	Doxazosin	9M4Q-Alpha1A-Doxazosin
20.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
20.00	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
20.00	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
20.00	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
20.00	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
20.00	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
20.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
20.00	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
20.00	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
20.00	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
20.00	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
20.00	Consensus	orexin_on	Orthosteric Ligand	ox2_on
20.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
20.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
20.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
20.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
20.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
19.35	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
19.23	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
19.23	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
19.23	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
19.23	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
19.23	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
19.23	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.05	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
19.05	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
19.05	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
19.05	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
19.05	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
19.05	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
19.05	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
19.05	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
19.05	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
19.05	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
19.05	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
19.05	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
19.05	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
18.75	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
18.75	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
18.75	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
18.75	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
18.75	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
18.75	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.75	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
18.75	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
18.75	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
18.75	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
18.75	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
18.75	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
18.75	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
18.75	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
18.75	Single	9H2X	A1IR1	9H2X-A_2A-A1IR1-Na
18.75	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
18.75	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
18.52	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
18.52	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
18.52	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
18.52	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
18.18	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
18.18	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
18.18	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
18.18	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
18.18	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
18.18	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
18.18	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
18.18	Single	8Y72	Peptide	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
17.86	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
17.86	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.86	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
17.86	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
17.86	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.86	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
17.86	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
17.65	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
17.65	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
17.65	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
17.65	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
17.65	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
17.65	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
17.65	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
17.65	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
17.65	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
17.65	Single	8K9L	Damgo	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
17.65	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
17.65	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
17.65	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
17.39	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
17.39	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
17.39	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.39	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
17.39	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
17.39	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
17.39	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
17.39	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
17.39	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
17.39	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
17.24	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
17.24	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.24	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
17.24	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.24	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
17.24	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
17.24	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.24	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
17.24	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
16.67	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
16.67	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
16.67	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
16.67	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
16.67	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
16.67	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
16.67	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.67	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
16.67	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
16.67	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
16.67	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
16.67	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
16.67	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
16.67	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
16.67	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
16.67	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.67	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
16.67	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
16.67	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
16.67	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
16.67	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
16.67	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
16.67	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
16.67	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
16.67	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
16.67	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
16.67	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
16.67	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
16.67	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
16.13	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.13	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
16.13	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
16.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
16.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
16.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
16.00	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
16.00	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
16.00	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
16.00	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
15.79	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
15.79	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
15.79	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
15.79	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
15.79	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
15.79	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
15.79	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
15.79	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
15.79	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
15.79	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
15.79	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
15.79	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
15.79	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
15.79	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
15.79	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
15.79	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
15.79	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
15.79	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
15.79	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
15.79	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.79	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.79	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
15.79	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
15.79	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
15.79	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
15.79	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
15.79	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
15.79	Consensus	blt_off	Orthosteric Ligand	blt1_off
15.79	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
15.79	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
15.79	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
15.79	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
15.79	Consensus	ep_off	Orthosteric Ligand	ep4_off
15.79	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
15.79	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
15.79	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
15.62	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
15.62	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.62	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.38	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
15.38	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
15.38	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
15.38	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
15.38	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
15.38	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.38	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
15.38	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
15.38	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
15.38	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
15.38	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.38	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.15	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
15.15	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
15.15	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
15.15	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
15.00	Single	3P0G	BI167107	3P0G-β₂-BI167107
15.00	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
15.00	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
15.00	Single	5TZR	MK8666	5TZR-FFA1-MK8666
15.00	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
15.00	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
15.00	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
15.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
15.00	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
15.00	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
15.00	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
15.00	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
15.00	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
15.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
15.00	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
15.00	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
15.00	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.00	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
15.00	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
15.00	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.00	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
15.00	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
15.00	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.00	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.00	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
15.00	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
15.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
15.00	Single	9I54	A1IZV	9I54-D₁-A1IZV-Gs/β1/γ2
15.00	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
15.00	Consensus	a2_on	Orthosteric Ligand	a2b_on
15.00	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
15.00	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
15.00	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
15.00	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
15.00	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
15.00	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.00	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
15.00	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
15.00	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
15.00	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.00	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
15.00	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
15.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
15.00	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
15.00	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
14.81	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
14.81	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
14.81	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.81	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.81	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.81	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
14.71	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
14.29	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
14.29	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
14.29	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
14.29	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
14.29	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
14.29	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
14.29	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
14.29	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
14.29	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
14.29	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
14.29	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
14.29	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
14.29	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
14.29	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
14.29	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
14.29	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
14.29	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
14.29	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
14.29	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
14.29	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
14.29	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
14.29	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
14.29	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
14.29	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
14.29	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
14.29	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
14.29	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
14.29	Single	9EE9	Adenosine	9EE9-A_2A-Adenosine-Gs/β1/γ2
14.29	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
14.29	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
14.29	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
14.29	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
14.29	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
14.29	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
14.29	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
14.29	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
14.29	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
14.29	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
14.29	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
14.29	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.29	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
14.29	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
14.29	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
14.29	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
14.29	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
14.29	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
13.89	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
13.79	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
13.79	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.79	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.79	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
13.79	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
13.79	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
13.79	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
13.79	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.79	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
13.64	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
13.64	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
13.64	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
13.64	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
13.64	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
13.64	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
13.64	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
13.64	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
13.64	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
13.64	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.64	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
13.64	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.64	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
13.64	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
13.64	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
13.64	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.64	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
13.64	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
13.33	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
13.33	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.33	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
13.33	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.33	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.33	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.33	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
13.33	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
13.33	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.33	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.33	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
13.33	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
13.33	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
13.33	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
13.33	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.33	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
13.33	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.33	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
13.33	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
13.16	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
13.04	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
13.04	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
13.04	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
13.04	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
13.04	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
13.04	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
13.04	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.04	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.04	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-Gz/β1/γ2
13.04	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
13.04	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
12.90	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
12.90	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.90	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
12.90	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
12.50	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
12.50	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
12.50	Single	6LI0	C17	6LI0-GPR52-C17
12.50	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
12.50	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
12.50	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
12.50	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.50	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7QA8	Peptide	7QA8-STE2-Peptide
12.50	Single	7QA8	Peptide	7QA8-STE2-Peptide
12.50	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.50	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
12.50	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
12.50	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
12.50	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
12.50	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
12.50	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.50	Single	8WKY	PG-934	8WKY-MC₄-PG-934
12.50	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
12.50	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
12.50	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
12.50	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
12.50	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
12.50	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
12.12	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.12	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
12.00	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.00	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
11.76	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
11.76	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
11.76	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.76	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
11.76	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
11.76	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
11.76	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
11.76	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.76	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.76	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.76	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
11.76	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.76	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
11.76	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
11.76	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
11.76	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
11.76	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
11.76	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
11.76	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
11.76	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
11.76	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.76	Single	9EBH	Adenosine	9EBH-A_3A-Adenosine-Gi1/β1/γ2
11.76	Single	9EEA	Adenosine	9EEA-A_2A-Adenosine-Gs/β1/γ2
11.76	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
11.76	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
11.76	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
11.76	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
11.76	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.76	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
11.76	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
11.76	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
11.76	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.76	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.54	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
11.54	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
11.54	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
11.43	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.43	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
11.11	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
11.11	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
11.11	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
11.11	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
11.11	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
11.11	Single	6IQL	L745870	6IQL-D₄-L745870
11.11	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
11.11	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
11.11	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
11.11	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
11.11	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
11.11	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
11.11	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
11.11	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
11.11	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
11.11	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
11.11	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
11.11	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
11.11	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
11.11	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
11.11	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
11.11	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.11	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
11.11	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
11.11	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
11.11	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
11.11	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
11.11	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
11.11	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
11.11	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
11.11	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
11.11	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
11.11	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.11	Single	9IXX	LTD4	9IXX-CysLT₂-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
11.11	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
11.11	Single	9KPD	SA0	9KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
11.11	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
11.11	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
11.11	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.81	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
10.81	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
10.71	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
10.71	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.71	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
10.71	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
10.71	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
10.53	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
10.53	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
10.53	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
10.53	Single	4QKX	35V	4QKX-β₂-35V
10.53	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
10.53	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
10.53	Single	5DHG	C-35	5DHG-NOP-C-35
10.53	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
10.53	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
10.53	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
10.53	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
10.53	Single	6GPS	MK0812	6GPS-CCR2-MK0812
10.53	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
10.53	Single	6PS1	Timolol	6PS1-β₂-Timolol
10.53	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
10.53	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
10.53	Single	7BU7	BI167107	7BU7-β₁-BI167107
10.53	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
10.53	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
10.53	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
10.53	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
10.53	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
10.53	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
10.53	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
10.53	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
10.53	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
10.53	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
10.53	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
10.53	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
10.53	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.53	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
10.53	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
10.53	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
10.53	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-Gi1/β1/γ1
10.53	Single	8T1W	CVN424	8T1W-GPR6-CVN424
10.53	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.53	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.53	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
10.53	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
10.53	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
10.53	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
10.53	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.53	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
10.53	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
10.53	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
10.53	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
10.53	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
10.53	Consensus	blt_on	Orthosteric Ligand	blt1_on
10.53	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
10.53	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
10.53	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.53	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
10.53	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
10.53	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
10.34	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
10.34	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.34	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
10.34	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
10.34	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
10.26	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.00	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
10.00	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
10.00	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
10.00	Single	5C1M	BU72	5C1M-μ-BU72
10.00	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
10.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
10.00	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
10.00	Single	6GPX	MK0812	6GPX-CCR2-MK0812
10.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
10.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
10.00	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
10.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.00	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
10.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
10.00	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
10.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
10.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
10.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
10.00	Single	7W41	PD176252	7W41-BB₂-PD176252
10.00	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
10.00	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
10.00	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
10.00	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
10.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
10.00	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
10.00	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.00	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
10.00	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
10.00	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
10.00	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
10.00	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
10.00	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
10.00	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
10.00	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
10.00	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
10.00	Single	9GE2	ML184	9GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
10.00	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
10.00	Single	9KPF	SA0	9KPF-TAS2R16-SA0-Gi1/β1/γ2
10.00	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
10.00	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
10.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
10.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
10.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
10.00	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
10.00	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
10.00	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
10.00	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
10.00	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
10.00	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
10.00	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
10.00	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
9.68	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.68	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
9.68	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
9.68	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.52	Single	2YDV	NECA	2YDV-A_2A-NECA
9.52	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
9.52	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
9.52	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
9.52	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
9.52	Single	5G53	NECA	5G53-A_2A-NECA-Gs
9.52	Single	5XR8	AM841	5XR8-CB₁-AM841
9.52	Single	5XRA	AM11542	5XRA-CB₁-AM11542
9.52	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
9.52	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
9.52	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
9.52	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
9.52	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
9.52	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
9.52	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.52	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
9.52	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
9.52	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
9.52	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
9.52	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
9.52	Single	8E0G	BU72	8E0G-μ-BU72
9.52	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
9.52	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
9.52	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
9.52	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
9.52	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
9.52	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
9.52	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
9.52	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
9.52	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
9.52	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
9.52	Single	9EGO	YVF	9EGO-CB₁-YVF-Gi1/β1/γ2
9.52	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
9.52	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
9.52	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
9.52	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
9.52	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
9.52	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.52	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
9.52	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.52	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
9.52	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
9.52	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
9.38	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.38	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
9.09	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
9.09	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
9.09	Single	4LDE	BI167107	4LDE-β₂-BI167107
9.09	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
9.09	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
9.09	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
9.09	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
9.09	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
9.09	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
9.09	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
9.09	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
9.09	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
9.09	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
9.09	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
9.09	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
9.09	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.09	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
9.09	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
9.09	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
9.09	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
9.09	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
9.09	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
9.09	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
9.09	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
9.09	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
9.09	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
9.09	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
9.09	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
9.09	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
9.09	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on adgrf_on adgrl_on adgre_on adgrd_on
9.09	Consensus	class-b2_on_gp	Orthosteric Ligand	adgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
9.09	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.09	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.09	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.09	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
9.09	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
9.09	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.09	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.82	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
8.82	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.82	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
8.70	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
8.70	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
8.70	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
8.70	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
8.70	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
8.70	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
8.70	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
8.70	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.70	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
8.70	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
8.70	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
8.70	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
8.70	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
8.70	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
8.70	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
8.70	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
8.70	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
8.70	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
8.70	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-Go/β1/γ2
8.70	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
8.70	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	9M1H	Prostaglandin E2	9M1H-EP₁-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
8.70	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
8.70	Consensus	endothelin_off	Orthosteric Ligand	etb_off
8.70	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
8.70	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.57	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
8.33	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
8.33	Single	6PT3	DPI-287	6PT3-δ-DPI-287
8.33	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
8.33	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
8.33	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
8.33	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
8.33	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
8.33	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
8.33	Single	9JF4	PD168368	9JF4-BB₁-PD168368
8.33	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.33	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
8.33	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
8.33	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
8.11	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
8.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
8.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
8.00	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
8.00	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
8.00	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
8.00	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
8.00	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
8.00	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
8.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.00	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
8.00	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
8.00	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
7.69	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
7.69	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
7.69	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.69	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
7.69	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
7.69	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
7.41	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
7.41	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
7.41	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.14	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
7.14	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
7.14	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
7.14	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
7.14	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.14	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.90	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
6.67	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
6.67	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.67	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
6.67	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
6.67	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.67	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
6.67	Consensus	sensory_on	Orthosteric Ligand	opsins_on
6.45	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
6.45	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
6.45	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.25	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.25	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.25	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
6.25	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.25	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
6.25	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.25	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
6.25	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.25	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
6.25	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
6.25	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.25	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
6.25	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
6.25	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
6.25	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
6.25	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
5.88	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
5.88	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.88	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.88	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
5.88	Single	6HLL	CP99994	6HLL-NK₁-CP99994
5.88	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.88	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
5.88	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
5.88	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
5.88	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.88	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88	Single	7XP6	Strychnine	7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.88	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.88	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
5.88	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
5.88	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.88	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
5.88	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
5.88	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
5.88	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.88	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.88	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.88	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9AS2	DMT	9AS2-5-HT_2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9B9Y	7DY	9B9Y-CB₁-7DY
5.88	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.88	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.88	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.56	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
5.56	Single	5U09	Taranabant	5U09-CB₁-Taranabant
5.56	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.56	Single	6AKX	A4R	6AKX-CCR5-A4R
5.56	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.56	Single	6B73	MP1104	6B73-κ-MP1104
5.56	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.56	Single	6OBA	S-Alprenolol	6OBA-β₂-S-Alprenolol-GTPL11074
5.56	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
5.56	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
5.56	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
5.56	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
5.56	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.56	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
5.56	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
5.56	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
5.56	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
5.56	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1
5.56	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
5.56	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
5.56	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
5.56	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
5.56	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
5.56	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.56	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.56	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
5.56	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go/β1/γ2
5.56	Single	9K6L	SA0	9K6L-TAS2R16-SA0-Gi2/β1/γ2
5.56	Single	9KPE	SA0	9KPE-TAS2R16-SA0-Gi1/β1/γ2
5.56	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.56	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.56	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
5.56	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.56	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
5.56	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.56	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
5.56	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
5.56	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.26	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.26	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
5.26	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
5.26	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
5.26	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.26	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
5.26	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.26	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.26	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
5.26	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
5.26	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
5.26	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
5.26	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.26	Single	6TPG	EMPA	6TPG-OX₂-EMPA
5.26	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.26	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.26	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.26	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
5.26	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
5.26	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
5.26	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.26	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.26	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
5.26	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
5.26	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
5.26	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
5.26	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
5.26	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
5.26	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.26	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
5.26	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
5.26	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
5.26	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
5.26	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
5.26	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
5.26	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
5.26	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
5.26	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
5.26	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
5.26	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.26	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.00	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.00	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.00	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
5.00	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
5.00	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
5.00	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.00	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
5.00	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
5.00	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.00	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.00	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
5.00	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
5.00	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
5.00	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
5.00	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
5.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.00	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.00	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
5.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.00	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.00	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
5.00	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
5.00	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
5.00	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.00	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.00	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.00	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
5.00	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
5.00	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
5.00	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
5.00	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
5.00	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
5.00	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
5.00	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
5.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
5.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.00	Single	8JXR	LSD	8JXR-D₁-LSD
5.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.00	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
5.00	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.00	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.00	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
5.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.00	Single	9AS1	DMT	9AS1-5-HT_2A-DMT
5.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.00	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.00	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
5.00	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.00	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.00	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.00	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.00	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.00	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
5.00	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
5.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.00	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
5.00	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
5.00	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.00	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
5.00	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.00	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.76	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
4.76	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.76	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
4.76	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
4.76	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
4.76	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
4.76	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
4.76	Single	5WQC	EMPA	5WQC-OX₂-EMPA
4.76	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-Cmpd-15
4.76	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
4.76	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.76	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
4.76	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.76	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
4.76	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
4.76	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
4.76	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.76	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.76	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
4.76	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
4.76	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.76	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.76	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.76	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
4.76	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.76	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
4.76	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
4.76	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
4.76	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.76	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.76	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
4.76	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
4.76	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
4.76	Single	9ARY	Serotonin	9ARY-5-HT_2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-Go/β1/γ2
4.76	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-Gi1/β1/γ2
4.76	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.76	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.76	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.76	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.76	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
4.76	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.76	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
4.76	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
4.76	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.76	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.76	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
4.76	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
4.76	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.76	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
4.76	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.76	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.76	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
4.55	Single	4DJH	JDTic	4DJH-κ-JDTic
4.55	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
4.55	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
4.55	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
4.55	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.55	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.55	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.55	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.55	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
4.55	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
4.55	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
4.55	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.55	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
4.55	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
4.55	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.55	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
4.55	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
4.55	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
4.55	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.55	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
4.55	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
4.55	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
4.55	Single	9CLW	TUG-1375	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
4.55	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
4.55	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
4.55	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.55	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
4.55	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
4.55	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.35	Single	3D4S	Timolol	3D4S-β₂-Timolol
4.35	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.35	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.35	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.35	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
4.35	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
4.35	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.35	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
4.35	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
4.35	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.35	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.17	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.17	Single	5X93	K-8794	5X93-ET_B-K-8794
4.17	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
4.17	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
4.17	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.17	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.17	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.17	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.17	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
4.17	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.17	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.17	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.45	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2

PDB Summary
PDB	6U1N
Class	A
SubFamily	Amine
Type	Acetylcholine (muscarinic)
SubType	M2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	LY2119620
Protein Partners	Arrestin2
PDB Resolution	4
Date	2020-02-26
D.O.I.	doi.org/10.1038/s41586-020-1954-0

Net Summary
I_min	1.71
Number of Linked Nodes	592
Number of Links	729
Number of Hubs	103
Number of Links mediated by Hubs	396
Number of Communities	30
Number of Nodes involved in Communities	197
Number of Links involved in Communities	268

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	306034
Length Of Smallest Path	3
Average Path Length	26.0492
Length of Longest Path	50
Minimum Path Strength	1.235
Average Path Strength	6.15024
Maximum Path Strength	67.49
Minimum Path Correlation	0.7
Average Path Correlation	0.970834
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.2168
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.6406
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • arrestin family protein binding • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • vasopressin receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • cellular response to stimulus • cellular response to nitrogen compound
Gene Ontology	Biological Process	• heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • regulation of body fluid levels • hemostasis • regulation of biological quality • regulation of tube diameter • regulation of tube size • positive regulation of biological process • positive regulation of vasoconstriction • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to endogenous stimulus • response to hormone • response to endogenous stimulus • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • positive regulation of signaling • renal system process • regulation of urine volume • renal water retention • negative regulation of urine volume • head development • forebrain development • animal organ development • brain development • central nervous system development • telencephalon development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • intracellular vesicle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • cytoplasm • organelle membrane • presynapse • somatodendritic compartment • dendrite • dendritic tree • neuron projection • cholinergic synapse • Golgi apparatus • endomembrane system • ciliary basal body • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • response to stimulus • immune response • immune system process • adaptive immune response • protein-containing complex • immunoglobulin complex • extracellular region • phosphoprotein binding • protein binding • binding • kinase binding • enzyme binding • protein kinase binding • mitogen-activated protein kinase kinase binding • arrestin family protein binding • protein-containing complex binding • AP-2 adaptor complex binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • protein phosphorylated amino acid binding • angiotensin receptor binding • signaling receptor binding • G protein-coupled receptor binding • molecular adaptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • insulin-like growth factor receptor binding • clathrin binding • adrenergic receptor binding • alpha-1B adrenergic receptor binding • transcription coactivator activity • transcription regulator activity • transcription coregulator activity • protein-macromolecule adaptor activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • cysteine-type endopeptidase regulator activity involved in apoptotic process • transmembrane transporter binding • alpha-1A adrenergic receptor binding • cargo adaptor activity • clathrin adaptor activity • follicle-stimulating hormone receptor binding • vasopressin receptor binding • V2 vasopressin receptor binding • transcription factor binding • RNA polymerase II-specific DNA-binding transcription factor binding • nuclear receptor binding • DNA-binding transcription factor binding • nuclear estrogen receptor binding • response to chemical • response to xenobiotic stimulus • interleukin-6 production • multicellular organismal process • regulation of cellular process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of biological process • negative regulation of metabolic process • biological regulation • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • negative regulation of post-translational protein modification • regulation of protein modification process • regulation of protein ubiquitination • regulation of primary metabolic process • protein ubiquitination • negative regulation of protein modification process • protein metabolic process • negative regulation of protein ubiquitination • regulation of protein modification by small protein conjugation or removal • protein modification process • negative regulation of protein metabolic process • negative regulation of protein modification by small protein conjugation or removal • regulation of post-translational protein modification • regulation of protein metabolic process • primary metabolic process • macromolecule modification • post-translational protein modification • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • actomyosin structure organization • actin cytoskeleton organization • actin filament organization • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • actin filament bundle organization • contractile actin filament bundle assembly • actin filament-based process • actin filament bundle assembly • stress fiber assembly • cellular component organization or biogenesis • supramolecular fiber organization • cytoskeleton organization • regulation of apoptotic process • apoptotic process • regulation of programmed cell death • cell death • programmed cell death • cellular response to stimulus • signaling • negative regulation of signaling • negative regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • negative regulation of cell communication • cell communication • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • negative regulation of response to stimulus • regulation of MAPK cascade • negative regulation of signal transduction • negative regulation of ERK1 and ERK2 cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • negative regulation of MAPK cascade • ovulation cycle process • reproductive process • sex differentiation • development of primary female sexual characteristics • developmental process involved in reproduction • ovulation cycle • multicellular organism development • development of primary sexual characteristics • anatomical structure development • reproductive structure development • ovarian follicle development • system development • rhythmic process • developmental process • gonad development • reproductive system development • female gonad development • multicellular organismal reproductive process • animal organ development • female sex differentiation • follicle-stimulating hormone signaling pathway • G protein-coupled receptor signaling pathway • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • regulation of small molecule metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • catabolic process • proteolysis involved in protein catabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • proteolysis • ubiquitin-dependent protein catabolic process • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • regulation of DNA-templated transcription • regulation of G protein-coupled receptor signaling pathway • response to morphine • response to isoquinoline alkaloid • response to nitrogen compound • response to alkaloid • negative regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of DNA-templated transcription • positive regulation of biological process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • negative adaptation of signaling pathway • import into cell • receptor internalization • transport • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • localization • G protein-coupled receptor internalization • establishment of localization • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • positive regulation of signaling • negative regulation of programmed cell death • negative regulation of apoptotic process • establishment of protein localization • nitrogen compound transport • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of protein metabolic process • positive regulation of post-translational protein modification • positive regulation of protein modification process • positive regulation of protein modification by small protein conjugation or removal • positive regulation of protein ubiquitination • neuron apoptotic process • negative regulation of neuron apoptotic process • regulation of neuron apoptotic process • proteasomal protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • system process • sensory perception • nervous system process • sensory perception of touch • sensory perception of mechanical stimulus • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • regulation of biological quality • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • cellular response to oxygen-containing compound • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • homeostatic process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • amide transport • signal release • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • response to oxygen-containing compound • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • cellular response to chemical stimulus • cellular homeostasis • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • phototransduction • detection of light stimulus • response to light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of phosphate metabolic process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of phosphorylation • pseudopodium • clathrin-coated pit • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • chromatin • chromosome • glutamatergic synapse • neuron spine • dendritic spine • postsynaptic density • neuron to neuron synapse • postsynaptic specialization • asymmetric synapse
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	2CU
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	2CU
Name	3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
Synonyms	LY2119620 positive allosteric modulator of M2/M4 receptor
Identifier
Formula	C19 H24 Cl N5 O3 S
Molecular Weight	437.944
SMILES
PubChem	57664406
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08172
Sequence	>6U1N_Chain_R T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N R H L Q T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G Y W P L G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P V K R T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G V R T V E D G E C Y I Q F F S N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C A P C I P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K K T F K E ?C ?? A ???L A K D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P29066
Sequence	>6U1N_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V D P V D G V V L V D P E Y L K E R R V Y V T L T V A F R Y G R E D L D V L G L T F R K D L F V A N V Q S F P P A P E D K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P S S V T L Q P G P E D T G K A L G V D Y E V K A F V A E N L E E K I H K R N S V R L V I R K V Q Y A P E R P G P Q P T A E T T R Q F L M S D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I V L F N T A Q Y K V P V A M E E A D D T V A P S S T F S K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V S R G G L L G D L A S S D V A V E L P F T L M H P K P K E E P P H R E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	3UON	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	3	2012-02-01	doi.org/10.1038/nature10753
	4MQS	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	-	-	3.5	2013-11-27	doi.org/10.1038/nature12735
	7T8X	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T8X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	5YC8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	2.5	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK3	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	2.6	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKB	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	AF-DX 384	-	-	2.95	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKC	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	2.3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8PM2	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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