psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E22	R:R:F21	3.5	No	No	0	5	3
2	R:R:V23	R:R:V85	4.81	No	No	0	4	6
3	R:R:F25	R:R:I26	5.02	No	No	0	3	6
4	R:R:A30	R:R:T81	5.03	No	No	0	7	7
5	R:R:L33	R:R:S32	4.5	No	No	0	6	5
6	R:R:M77	R:R:S34	3.07	No	No	0	9	8
7	R:R:S433	R:R:T37	3.2	No	No	0	9	8
8	R:R:T37	R:R:T434	10.99	No	No	0	8	7
9	R:R:G40	R:R:L43	3.42	No	No	0	9	8
10	R:R:A66	R:R:N41	4.69	No	No	0	9	9
11	R:R:F451	R:R:L43	3.65	No	No	0	9	8
12	R:R:A441	R:R:V44	3.39	No	No	4	8	9
13	R:R:F447	R:R:V44	6.55	Yes	No	4	9	9
14	R:R:A66	R:R:M45	3.22	No	Yes	0	9	7
15	R:R:F447	R:R:S47	5.28	Yes	Yes	0	9	9
16	R:R:I48	R:R:K49	5.82	No	No	0	8	5
17	R:R:F63	R:R:I48	5.02	No	No	0	7	8
18	R:R:L454	R:R:V50	4.47	No	No	0	7	7
19	R:R:L54	R:R:N51	5.49	Yes	No	0	9	8
20	R:R:Q55	R:R:R52	4.67	No	No	0	8	8
21	R:R:L54	R:R:N59	6.87	Yes	No	0	9	9
22	R:R:L54	R:R:T446	5.9	Yes	No	0	9	7
23	R:R:F447	R:R:L54	4.87	Yes	Yes	0	9	9
24	R:R:L54	R:R:T450	5.9	Yes	No	0	9	8
25	R:R:Q55	R:R:Y60	13.53	No	No	0	8	8
26	R:R:T56	R:R:V57	3.17	No	No	0	8	7
27	R:R:R135	R:R:V57	10.46	Yes	No	0	8	7
28	R:R:D120	R:R:N58	8.08	Yes	No	0	9	9
29	R:R:F61	R:R:I116	5.02	Yes	No	0	8	8
30	R:R:F61	R:R:I117	3.77	Yes	Yes	0	8	9
31	R:R:D120	R:R:F61	8.36	Yes	Yes	0	9	8
32	R:R:A140	R:R:F61	4.16	No	Yes	0	8	8
33	R:R:N113	R:R:S64	7.45	No	No	0	9	9
34	R:R:I144	R:R:S64	6.19	No	No	0	9	9
35	R:R:L65	R:R:N113	6.87	No	No	0	9	9
36	R:R:L114	R:R:L65	4.15	No	No	0	9	9
37	R:R:L65	R:R:N436	10.98	No	Yes	0	9	9
38	R:R:D69	R:R:S110	4.42	No	No	0	9	9
39	R:R:D69	R:R:S433	8.83	No	No	0	9	9
40	R:R:D69	R:R:N436	6.73	No	Yes	0	9	9
41	R:R:I71	R:R:V106	10.75	No	No	0	8	7
42	R:R:I72	R:R:S76	7.74	No	Yes	0	8	8
43	R:R:I72	R:R:V106	3.07	No	No	0	8	7
44	R:R:I72	R:R:S107	4.64	No	No	0	8	8
45	R:R:F75	R:R:V74	3.93	Yes	No	0	5	5
46	R:R:F75	R:R:S76	5.28	Yes	Yes	0	5	8
47	R:R:F75	R:R:W99	4.01	Yes	Yes	0	5	7
48	R:R:F75	R:R:L102	4.87	Yes	No	0	5	6
49	R:R:D103	R:R:S76	10.31	No	Yes	1	9	8
50	R:R:S76	R:R:Y430	3.82	Yes	Yes	1	8	9
51	R:R:M77	R:R:Y430	4.79	No	Yes	0	9	9
52	R:R:L79	R:R:N78	6.87	No	No	0	7	9
53	R:R:L79	R:R:W99	7.97	No	Yes	0	7	7
54	R:R:Y426	R:R:Y80	15.89	Yes	No	0	7	8
55	R:R:W427	R:R:Y80	3.86	No	No	0	9	8
56	R:R:Y80	W:W:?2	6.03	No	Yes	0	8	0
57	R:R:W89	R:R:Y83	6.75	Yes	No	0	9	7
58	R:R:Y83	W:W:?2	6.03	No	Yes	0	7	0
59	R:R:T84	W:W:?2	6.5	No	Yes	0	7	0
60	R:R:G87	R:R:I86	3.53	No	No	0	6	6
61	R:R:I86	R:R:Y88	8.46	No	No	0	6	4
62	R:R:I86	R:R:P90	3.39	No	No	0	6	4
63	R:R:P90	R:R:W89	5.4	No	Yes	3	4	9
64	R:R:L91	R:R:W89	12.53	No	Yes	3	8	9
65	R:R:V95	R:R:W89	6.13	No	Yes	3	6	9
66	R:R:C96	R:R:W89	11.75	No	Yes	3	9	9
67	R:R:C176	R:R:W89	5.22	No	Yes	3	9	9
68	R:R:L91	R:R:P90	3.28	No	No	3	8	4
69	R:R:L91	R:R:V95	5.96	No	No	3	8	6
70	R:R:G92	R:R:P93	4.06	No	No	0	7	4
71	R:R:P93	R:R:R169	10.09	No	No	0	4	8
72	R:R:C96	R:R:D97	6.22	No	No	0	9	7
73	R:R:C176	R:R:C96	7.28	No	No	3	9	9
74	R:R:L160	R:R:L98	4.15	No	No	0	6	6
75	R:R:L100	R:R:W99	5.69	No	Yes	0	7	7
76	R:R:D103	R:R:W99	3.35	No	Yes	0	9	7
77	R:R:L100	R:R:Y104	7.03	No	Yes	0	7	8
78	R:R:C176	R:R:L100	3.17	No	No	0	9	7
79	R:R:A101	R:R:I159	3.25	No	No	0	8	8
80	R:R:A101	R:R:L160	4.73	No	No	0	8	6
81	R:R:D103	R:R:Y430	12.64	No	Yes	1	9	9
82	R:R:W155	R:R:Y104	5.79	Yes	Yes	1	8	8
83	R:R:Y104	R:R:Y403	9.93	Yes	No	1	8	8
84	R:R:Y104	R:R:Y426	9.93	Yes	Yes	1	8	7
85	L:L:?1	R:R:Y104	12.54	Yes	Yes	1	0	8
86	R:R:S151	R:R:V105	4.85	No	No	0	9	8
87	R:R:F152	R:R:V105	3.93	No	No	0	5	8
88	R:R:S107	R:R:W400	4.94	No	Yes	1	8	9
89	L:L:?1	R:R:S107	11.78	Yes	No	1	0	8
90	R:R:N108	R:R:S151	8.94	Yes	No	0	9	9
91	R:R:L154	R:R:N108	4.12	Yes	Yes	1	8	9
92	R:R:N108	R:R:W155	7.91	Yes	Yes	1	9	8
93	R:R:A194	R:R:N108	3.13	No	Yes	1	8	9
94	L:L:?1	R:R:N108	6.86	Yes	Yes	1	0	9
95	R:R:A109	R:R:W148	7.78	No	No	0	8	9
96	R:R:A109	R:R:S151	3.42	No	No	0	8	9
97	R:R:L114	R:R:Y440	9.38	No	Yes	0	9	9
98	R:R:F119	R:R:L115	6.09	Yes	No	0	7	7
99	R:R:F119	R:R:I116	3.77	Yes	No	0	7	8
100	R:R:I116	R:R:M143	8.75	No	No	0	8	8
101	R:R:I117	R:R:R121	6.26	Yes	No	6	9	9
102	R:R:I117	R:R:Y440	3.63	Yes	Yes	6	9	9
103	R:R:M202	R:R:S118	4.6	No	No	0	9	9
104	R:R:S118	R:R:Y206	11.45	No	Yes	0	9	9
105	R:R:F119	R:R:L205	6.09	Yes	No	0	7	8
106	R:R:D120	R:R:Y131	9.2	Yes	Yes	5	9	9
107	R:R:D120	R:R:R135	4.76	Yes	Yes	5	9	8
108	R:R:R121	R:R:Y206	6.17	No	Yes	0	9	9
109	R:R:R121	R:R:Y440	8.23	No	Yes	6	9	9
110	R:R:F123	R:R:Y122	7.22	No	Yes	0	6	9
111	R:R:T126	R:R:Y122	14.98	No	Yes	0	8	9
112	R:R:L205	R:R:Y122	4.69	No	Yes	0	8	9
113	R:R:H208	R:R:Y122	6.53	No	Yes	0	6	9
114	R:R:I209	R:R:Y122	3.63	No	Yes	0	9	9
115	R:R:F123	R:R:Y131	11.35	No	Yes	0	6	9
116	R:R:C124	R:R:Y131	4.03	No	Yes	0	8	9
117	R:R:K127	R:R:P128	3.35	No	No	0	7	9
118	R:R:L129	R:R:P128	3.28	No	No	0	7	9
119	R:R:L129	R:R:T130	5.9	No	No	0	7	6
120	R:R:K134	R:R:T130	4.5	No	No	0	6	6
121	R:R:R135	R:R:Y131	16.46	Yes	Yes	5	8	9
122	R:R:I144	R:R:W148	4.7	No	No	0	9	9
123	R:R:A156	R:R:F152	5.55	No	No	0	6	5
124	R:R:L154	R:R:W155	5.69	Yes	Yes	1	8	8
125	R:R:L154	R:R:T190	4.42	Yes	No	1	8	9
126	R:R:T190	R:R:W155	10.92	No	Yes	1	9	8
127	R:R:A194	R:R:W155	3.89	No	Yes	1	8	8
128	L:L:?1	R:R:W155	7.31	Yes	Yes	1	0	8
129	R:R:I159	R:R:Q179	5.49	No	Yes	0	8	7
130	R:R:V166	R:R:W162	3.68	No	No	0	4	6
131	R:R:Q179	R:R:W162	6.57	Yes	No	0	7	6
132	R:R:F180	R:R:W162	9.02	No	No	0	7	6
133	R:R:F164	R:R:Q163	10.54	No	No	0	6	7
134	R:R:R169	R:R:V171	3.92	No	No	0	8	4
135	R:R:V171	R:R:Y177	15.14	No	No	0	4	4
136	R:R:E172	R:R:E175	11.42	No	Yes	0	1	5
137	R:R:D173	R:R:G174	3.35	No	No	0	3	3
138	R:R:E175	R:R:G174	3.27	Yes	No	0	5	3
139	R:R:Y177	W:W:?2	37.06	No	Yes	0	4	0
140	R:R:F180	R:R:I178	11.3	No	No	0	7	7
141	R:R:F180	R:R:V186	3.93	No	No	0	7	8
142	R:R:F181	R:R:N410	12.08	Yes	No	2	5	4
143	R:R:F181	R:R:W422	5.01	Yes	Yes	2	5	6
144	R:R:F181	W:W:?2	19.7	Yes	Yes	2	5	0
145	R:R:N183	R:R:V186	10.35	No	No	0	7	8
146	R:R:A184	R:R:T411	3.36	No	No	0	4	7
147	R:R:T187	R:R:T411	6.28	No	No	0	8	7
148	R:R:F188	R:R:L408	8.53	No	No	0	7	7
149	R:R:F188	R:R:F412	4.29	No	No	0	7	7
150	R:R:A191	R:R:L408	4.73	No	No	0	8	7
151	R:R:I192	R:R:Y196	9.67	No	Yes	0	7	8
152	L:L:?1	R:R:A194	5.62	Yes	No	1	0	8
153	R:R:F195	R:R:Y196	5.16	Yes	Yes	0	9	8
154	R:R:F195	R:R:V199	3.93	Yes	No	1	9	7
155	R:R:F195	R:R:F396	5.36	Yes	Yes	1	9	9
156	R:R:F195	R:R:N404	15.71	Yes	No	1	9	7
157	L:L:?1	R:R:F195	3.48	Yes	Yes	1	0	9
158	R:R:L408	R:R:Y196	3.52	No	Yes	0	7	8
159	R:R:F396	R:R:V199	3.93	Yes	No	1	9	7
160	R:R:I397	R:R:V199	3.07	No	No	0	7	7
161	R:R:F396	R:R:M202	4.98	Yes	No	0	9	9
162	R:R:L393	R:R:T203	4.42	No	No	0	8	6
163	R:R:I389	R:R:Y206	9.67	Yes	Yes	0	9	9
164	R:R:L393	R:R:Y206	3.52	No	Yes	0	8	9
165	R:R:H208	R:R:W207	5.29	No	No	0	6	4
166	R:R:R211	R:R:W207	6	No	No	0	5	4
167	R:R:S210	R:R:T386	4.8	No	No	0	8	8
168	R:R:I389	R:R:S210	3.1	Yes	No	0	9	8
169	R:R:S213	R:R:V385	8.08	No	No	0	8	8
170	R:R:K214	R:R:R216	8.66	No	No	0	7	8
171	R:R:E382	R:R:K214	14.85	No	No	0	9	7
172	R:R:R381	R:R:S215	5.27	No	No	0	7	6
173	R:R:K384	R:R:S380	4.59	No	No	0	9	5
174	R:R:C439	R:R:I392	3.27	No	No	0	9	9
175	R:R:I392	R:R:Y440	8.46	No	Yes	0	9	9
176	R:R:F396	R:R:W400	7.02	Yes	Yes	1	9	9
177	R:R:T399	R:R:W400	4.85	No	Yes	1	9	9
178	R:R:N432	R:R:T399	11.7	Yes	No	1	9	9
179	R:R:N432	R:R:W400	10.17	Yes	Yes	1	9	9
180	L:L:?1	R:R:W400	30.87	Yes	Yes	1	0	9
181	R:R:A401	R:R:P402	3.74	No	No	0	7	9
182	R:R:N404	R:R:Y403	9.3	No	No	1	7	8
183	L:L:?1	R:R:Y403	15.89	Yes	No	1	0	8
184	L:L:?1	R:R:N404	3.92	Yes	No	1	0	7
185	R:R:I417	R:R:N410	14.16	Yes	No	2	7	4
186	R:R:N410	R:R:W422	12.43	No	Yes	2	4	6
187	R:R:F412	R:R:T411	9.08	No	No	0	7	7
188	R:R:C413	R:R:C416	7.28	No	No	0	7	7
189	R:R:C416	R:R:I417	3.27	No	Yes	0	7	7
190	R:R:I417	R:R:P418	3.39	Yes	No	0	7	7
191	R:R:I417	R:R:W422	4.7	Yes	Yes	2	7	6
192	R:R:P418	R:R:V421	5.3	No	No	0	7	5
193	R:R:N419	R:R:W422	5.65	No	Yes	2	4	6
194	R:R:N419	W:W:?2	7.07	No	Yes	2	4	0
195	R:R:W422	W:W:?2	48.57	Yes	Yes	2	6	0
196	R:R:T423	R:R:W427	8.49	No	No	0	6	9
197	R:R:Y426	R:R:Y430	10.92	Yes	Yes	1	7	9
198	L:L:?1	R:R:Y426	13.38	Yes	Yes	1	0	7
199	L:L:?1	R:R:C429	5.66	Yes	No	0	0	8
200	L:L:?1	R:R:Y430	6.69	Yes	Yes	1	0	9
201	R:R:N432	R:R:N436	12.26	Yes	Yes	0	9	9
202	R:R:N436	R:R:P437	3.26	Yes	No	0	9	9
203	R:R:A441	R:R:F447	6.93	No	Yes	4	8	9
204	R:R:F447	R:R:L442	4.87	Yes	No	0	9	7
205	R:R:K448	R:R:L442	4.23	No	No	0	9	7
206	R:R:N444	R:R:T446	4.39	No	No	0	9	7
207	R:R:F447	R:R:N444	3.62	Yes	No	0	9	9
208	R:R:K449	R:R:K452	10.06	No	No	0	6	7
209	R:R:H453	R:R:L454	9	No	No	0	6	7
210	R:R:M406	R:R:V421	3.04	No	No	0	7	5
211	R:R:M77	R:R:T81	3.01	No	No	0	9	7
212	R:R:L454	R:R:S47	3	No	Yes	0	7	9
213	R:R:K127	R:R:T126	3	No	No	0	7	8
214	R:R:L70	R:R:V74	2.98	No	No	0	8	5
215	R:R:L98	R:R:V94	2.98	No	No	0	6	4
216	R:R:N108	R:R:V111	2.96	Yes	No	0	9	9
217	R:R:I38	R:R:I42	2.94	No	No	0	7	6
218	R:R:I409	R:R:I417	2.94	No	Yes	0	7	7
219	R:R:F161	R:R:P157	2.89	No	No	0	7	8
220	R:R:K138	R:R:M139	2.88	No	No	0	5	8
221	R:R:K138	R:R:M142	2.88	No	No	0	5	4
222	R:R:I117	R:R:L62	2.85	Yes	No	0	9	8
223	R:R:I192	R:R:L197	2.85	No	No	0	7	7
224	R:R:I200	R:R:L197	2.85	No	No	0	5	7
225	R:R:I431	R:R:L428	2.85	No	No	0	6	8
226	R:R:L70	R:R:M45	2.83	No	Yes	0	8	7
227	R:R:L115	R:R:M112	2.83	No	No	0	7	8
228	R:R:A401	R:R:F195	2.77	No	Yes	0	7	9
229	R:R:H208	R:R:V204	2.77	No	No	0	6	5
230	R:R:R381	R:R:S213	2.64	No	No	0	7	8
231	R:R:F181	R:R:V407	2.62	Yes	No	0	5	8
232	R:R:D97	R:R:Q179	2.61	No	Yes	0	7	7
233	R:R:A68	R:R:W148	2.59	No	No	0	9	9
234	R:R:H53	R:R:N51	2.55	No	No	0	6	8
235	R:R:F119	R:R:I201	2.51	Yes	No	0	7	7
236	R:R:T137	R:R:Y60	2.5	No	No	0	5	8
237	R:R:F63	R:R:M45	2.49	No	Yes	0	7	7
238	R:R:M139	R:R:R135	2.48	No	Yes	0	8	8
239	R:R:F451	R:R:K452	2.48	No	No	0	9	7
240	R:R:I48	R:R:Y60	2.42	No	No	0	8	8
241	R:R:I26	R:R:W427	2.35	No	No	0	6	9
242	R:R:E382	R:R:R381	2.33	No	No	0	9	7
243	R:R:E175	R:R:Y83	2.24	Yes	No	0	5	7
244	R:R:E175	R:R:Y177	2.24	Yes	No	0	5	4
245	R:R:F21	R:R:F25	2.14	No	No	0	3	3
246	R:R:A30	R:R:G31	1.95	No	No	0	7	4
247	R:R:A156	R:R:P157	1.87	No	No	0	6	8
248	R:R:A414	R:R:P415	1.87	No	No	0	3	4
249	R:R:A395	R:R:C439	1.81	No	No	0	8	9
250	R:R:P437	R:R:V44	1.77	No	No	0	9	9
251	R:R:G73	R:R:I38	1.76	No	No	0	8	7
252	R:R:G40	R:R:I39	1.76	No	No	0	9	5
253	R:R:G141	R:R:I144	1.76	No	No	0	4	9
254	R:R:G425	R:R:M406	1.75	No	No	0	6	7
255	R:R:G425	R:R:L428	1.71	No	No	0	6	8
256	R:R:A212	R:R:V125	1.7	No	No	0	7	8
257	R:R:M112	R:R:P198	1.68	No	No	0	8	9
258	R:R:A212	R:R:T126	1.68	No	No	0	7	8
259	R:R:S32	R:R:V29	1.62	No	No	0	5	4
260	R:R:C67	R:R:M45	1.62	No	Yes	0	7	7
261	R:R:S47	R:R:V46	1.62	Yes	No	0	9	6
262	R:R:A147	R:R:M112	1.61	No	No	0	8	8
263	R:R:A445	R:R:K448	1.61	No	No	0	5	9
264	R:R:V166	R:R:V168	1.6	No	No	0	4	3
265	R:R:T434	R:R:V36	1.59	No	No	0	7	5
266	R:R:T84	R:R:V85	1.59	No	No	0	7	6
267	R:R:A193	R:R:L154	1.58	No	Yes	0	6	8
268	R:R:A185	R:R:N183	1.56	No	No	0	4	7
269	R:R:I153	R:R:V149	1.54	No	No	0	5	5
270	R:R:I165	R:R:V166	1.54	No	No	0	5	4
271	R:R:I209	R:R:V385	1.54	No	No	0	9	8
272	R:R:I389	R:R:V385	1.54	Yes	No	0	9	8
273	R:R:I389	R:R:T388	1.52	Yes	No	0	9	9
274	R:R:I424	R:R:T420	1.52	No	No	0	5	4
275	R:R:M139	R:R:T136	1.51	No	No	0	8	9
276	R:R:F188	R:R:G189	1.51	No	No	0	7	6
277	R:R:L35	R:R:S34	1.5	No	No	0	6	8
278	R:R:L43	R:R:S47	1.5	No	Yes	0	8	9
279	R:R:L28	R:R:V27	1.49	No	No	0	4	5
280	R:R:L82	R:R:V27	1.49	No	No	0	5	5
281	R:R:L82	R:R:V85	1.49	No	No	0	5	6
282	R:R:I38	R:R:I39	1.47	No	No	0	7	5
283	R:R:I431	R:R:L33	1.43	No	No	0	6	6
284	R:R:I389	R:R:L390	1.43	Yes	No	0	9	7
285	R:R:Q179	R:R:T170	1.42	Yes	No	0	7	5
286	R:R:I435	R:R:N432	1.42	No	Yes	0	6	9
287	R:R:P132	R:R:Y131	1.39	No	Yes	0	7	9
288	R:R:F21	R:R:T20	1.3	No	No	0	3	5
289	R:R:V405	R:R:Y196	1.26	No	Yes	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M45	2.54	4	0	7
2	R:R:S47	2.85	4	0	9
3	R:R:L54	5.806	5	0	9
4	R:R:F61	5.3275	4	0	8
5	R:R:F75	4.5225	4	0	5
6	R:R:S76	6.7875	4	1	8
7	R:R:W89	7.96333	6	3	9
8	R:R:W99	5.255	4	0	7
9	R:R:Y104	9.044	5	1	8
10	R:R:N108	5.65333	6	1	9
11	R:R:I117	4.1275	4	6	9
12	R:R:F119	4.615	4	0	7
13	R:R:D120	7.6	4	5	9
14	R:R:Y122	7.41	5	0	9
15	R:R:Y131	8.486	5	5	9
16	R:R:R135	8.54	4	5	8
17	R:R:L154	3.9525	4	1	8
18	R:R:W155	6.91833	6	1	8
19	R:R:E175	4.7925	4	0	5
20	R:R:Q179	4.0225	4	0	7
21	R:R:F181	9.8525	4	2	5
22	R:R:F195	6.06833	6	1	9
23	R:R:Y196	4.9025	4	0	8
24	R:R:Y206	7.7025	4	0	9
25	R:R:I389	3.452	5	0	9
26	R:R:F396	5.3225	4	1	9
27	R:R:W400	11.57	5	1	9
28	R:R:I417	5.692	5	2	7
29	R:R:W422	15.272	5	2	6
30	R:R:Y426	12.53	4	1	7
31	R:R:Y430	7.772	5	1	9
32	R:R:N432	8.8875	4	1	9
33	R:R:N436	8.3075	4	0	9
34	R:R:Y440	7.425	4	6	9
35	R:R:F447	5.35333	6	4	9
36	L:L:?1	10.3333	12	1	0
37	W:W:?2	18.7086	7	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I26	R:R:W427	10.0065	2.35	No	No	0	6	9
2	R:R:W427	R:R:Y80	13.9808	3.86	No	No	0	9	8
3	R:R:Y80	W:W:?2	66.9615	6.03	No	Yes	0	8	0
4	R:R:T84	W:W:?2	11.8757	6.5	No	Yes	0	7	0
5	R:R:M77	R:R:Y430	14.0397	4.79	No	Yes	0	9	9
6	R:R:Y426	R:R:Y80	76.7026	15.89	Yes	No	0	7	8
7	R:R:W422	W:W:?2	29.8013	48.57	Yes	Yes	2	6	0
8	R:R:I417	R:R:W422	26.1336	4.7	Yes	Yes	2	7	6
9	R:R:I417	R:R:P418	18.4622	3.39	Yes	No	0	7	7
10	R:R:P418	R:R:V421	16.4573	5.3	No	No	0	7	5
11	R:R:M406	R:R:V421	14.4407	3.04	No	No	0	7	5
12	R:R:G425	R:R:M406	12.4123	1.75	No	No	0	6	7
13	R:R:G425	R:R:L428	10.3721	1.71	No	No	0	6	8
14	L:L:?1	R:R:Y426	67.5276	13.38	Yes	Yes	1	0	7
15	L:L:?1	R:R:W400	100	30.87	Yes	Yes	1	0	9
16	R:R:N432	R:R:W400	69.5678	10.17	Yes	Yes	1	9	9
17	R:R:N432	R:R:N436	68.3354	12.26	Yes	Yes	0	9	9
18	R:R:D69	R:R:N436	11.0679	6.73	No	Yes	0	9	9
19	R:R:N436	R:R:P437	49.2305	3.26	Yes	No	0	9	9
20	R:R:P437	R:R:V44	47.6856	1.77	No	No	0	9	9
21	R:R:F447	R:R:V44	44.4012	6.55	Yes	No	4	9	9
22	R:R:F447	R:R:S47	24.9779	5.28	Yes	Yes	0	9	9
23	R:R:L43	R:R:S47	16.4338	1.5	No	Yes	0	8	9
24	R:R:L70	R:R:M45	29.477	2.83	No	Yes	0	8	7
25	R:R:L70	R:R:V74	32.1422	2.98	No	No	0	8	5
26	R:R:F75	R:R:V74	34.7898	3.93	Yes	No	0	5	5
27	R:R:F75	R:R:S76	37.1307	5.28	Yes	Yes	0	5	8
28	R:R:S76	R:R:Y430	27.136	3.82	Yes	Yes	1	8	9
29	R:R:F63	R:R:M45	18.9988	2.49	No	Yes	0	7	7
30	R:R:F63	R:R:I48	16.2804	5.02	No	No	0	7	8
31	R:R:F447	R:R:L54	11.0266	4.87	Yes	Yes	0	9	9
32	R:R:I48	R:R:Y60	10.8084	2.42	No	No	0	8	8
33	L:L:?1	R:R:F195	61.2595	3.48	Yes	Yes	1	0	9
34	R:R:F195	R:R:F396	53.6175	5.36	Yes	Yes	1	9	9
35	R:R:F396	R:R:M202	99.829	4.98	Yes	No	0	9	9
36	R:R:M202	R:R:S118	98.3784	4.6	No	No	0	9	9
37	R:R:S118	R:R:Y206	96.7746	11.45	No	Yes	0	9	9
38	R:R:R121	R:R:Y206	51.9606	6.17	No	Yes	0	9	9
39	R:R:I117	R:R:R121	41.5826	6.26	Yes	No	6	9	9
40	R:R:F61	R:R:I117	72.7637	3.77	Yes	Yes	0	8	9
41	R:R:D120	R:R:F61	40.2028	8.36	Yes	Yes	0	9	8
42	R:R:D120	R:R:R135	21.0979	4.76	Yes	Yes	5	9	8
43	R:R:F396	R:R:W400	56.0175	7.02	Yes	Yes	1	9	9
44	R:R:L65	R:R:N436	48.7588	10.98	No	Yes	0	9	9
45	R:R:L114	R:R:L65	48.6349	4.15	No	No	0	9	9
46	R:R:L114	R:R:Y440	47.721	9.38	No	Yes	0	9	9
47	R:R:I117	R:R:Y440	36.3996	3.63	Yes	Yes	6	9	9
48	R:R:F61	R:R:I116	28.8284	5.02	Yes	No	0	8	8
49	L:L:?1	R:R:N108	24.005	6.86	Yes	Yes	1	0	9
50	R:R:N108	R:R:S151	19.5943	8.94	Yes	No	0	9	9
51	R:R:I72	R:R:S76	14.7002	7.74	No	Yes	0	8	8
52	R:R:I72	R:R:S107	16.8229	4.64	No	No	0	8	8
53	R:R:L100	R:R:Y104	47.7681	7.03	No	Yes	0	7	8
54	R:R:L100	R:R:W99	11.9641	5.69	No	Yes	0	7	7
55	R:R:Y83	W:W:?2	15.4785	6.03	No	Yes	0	7	0
56	R:R:C176	R:R:W89	14.3817	5.22	No	Yes	3	9	9
57	R:R:C176	R:R:L100	47.4085	3.17	No	No	0	9	7
58	R:R:Y177	W:W:?2	16.9468	37.06	No	Yes	0	4	0
59	R:R:C96	R:R:D97	35.6094	6.22	No	No	0	9	7
60	R:R:D97	R:R:Q179	33.5692	2.61	No	Yes	0	7	7
61	R:R:I159	R:R:Q179	10.6964	5.49	No	Yes	0	8	7
62	R:R:S151	R:R:V105	11.7283	4.85	No	No	0	9	8
63	R:R:F119	R:R:I116	23.0084	3.77	Yes	No	0	7	8
64	R:R:F119	R:R:L115	13.0373	6.09	Yes	No	0	7	7
65	R:R:I389	R:R:Y206	57.126	9.67	Yes	Yes	0	9	9
66	R:R:I389	R:R:V385	47.4438	1.54	Yes	No	0	9	8
67	R:R:I209	R:R:V385	34.8782	1.54	No	No	0	9	8
68	R:R:I209	R:R:Y122	32.9736	3.63	No	Yes	0	9	9
69	R:R:D120	R:R:Y131	13.3439	9.2	Yes	Yes	5	9	9
70	R:R:T126	R:R:Y122	23.3445	14.98	No	Yes	0	8	9
71	R:R:H208	R:R:Y122	11.7637	6.53	No	Yes	0	6	9
72	R:R:K127	R:R:T126	14.6766	3	No	No	0	7	8
73	R:R:K127	R:R:P128	11.7637	3.35	No	No	0	7	9
74	R:R:Q179	R:R:W162	19.5236	6.57	Yes	No	0	7	6
75	R:R:F180	R:R:W162	10.9617	9.02	No	No	0	7	6
76	R:R:F188	R:R:L408	10.6079	8.53	No	No	0	7	7
77	R:R:L408	R:R:Y196	13.8982	3.52	No	Yes	0	7	8
78	R:R:F195	R:R:Y196	22.1593	5.16	Yes	Yes	0	9	8
79	R:R:S213	R:R:V385	13.456	8.08	No	No	0	8	8
80	R:R:R381	R:R:S213	11.4217	2.64	No	No	0	7	8
81	R:R:M139	R:R:R135	13.0845	2.48	No	Yes	0	8	8
82	L:L:?1	R:R:Y430	37.6319	6.69	Yes	Yes	1	0	9
83	L:L:?1	R:R:Y104	42.5143	12.54	Yes	Yes	1	0	8
84	R:R:C176	R:R:C96	31.7766	7.28	No	No	3	9	9
85	R:R:S107	R:R:W400	15.3488	4.94	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I72	R:R:S76	7.74	0	No	Yes	8	8	2	2
R:R:I72	R:R:S107	4.64	0	No	No	8	8	2	1
R:R:D103	R:R:S76	10.31	1	No	Yes	9	8	2	2
R:R:S76	R:R:Y430	3.82	1	Yes	Yes	8	9	2	1
R:R:M77	R:R:Y430	4.79	0	No	Yes	9	9	2	1
R:R:Y426	R:R:Y80	15.89	1	Yes	No	7	8	1	2
R:R:L100	R:R:Y104	7.03	0	No	Yes	7	8	2	1
R:R:D103	R:R:Y430	12.64	1	No	Yes	9	9	2	1
R:R:W155	R:R:Y104	5.79	1	Yes	Yes	8	8	1	1
R:R:Y104	R:R:Y403	9.93	1	Yes	No	8	8	1	1
R:R:Y104	R:R:Y426	9.93	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y104	12.54	1	Yes	Yes	0	8	0	1
R:R:S107	R:R:W400	4.94	1	No	Yes	8	9	1	1
L:L:?1	R:R:S107	11.78	1	Yes	No	0	8	0	1
R:R:N108	R:R:S151	8.94	1	Yes	No	9	9	1	2
R:R:L154	R:R:N108	4.12	1	Yes	Yes	8	9	2	1
R:R:N108	R:R:W155	7.91	1	Yes	Yes	9	8	1	1
R:R:A194	R:R:N108	3.13	1	No	Yes	8	9	1	1
L:L:?1	R:R:N108	6.86	1	Yes	Yes	0	9	0	1
R:R:L154	R:R:W155	5.69	1	Yes	Yes	8	8	2	1
R:R:L154	R:R:T190	4.42	1	Yes	No	8	9	2	2
R:R:T190	R:R:W155	10.92	1	No	Yes	9	8	2	1
R:R:A194	R:R:W155	3.89	1	No	Yes	8	8	1	1
L:L:?1	R:R:W155	7.31	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A194	5.62	1	Yes	No	0	8	0	1
R:R:F195	R:R:Y196	5.16	1	Yes	Yes	9	8	1	2
R:R:F195	R:R:V199	3.93	1	Yes	No	9	7	1	2
R:R:F195	R:R:F396	5.36	1	Yes	Yes	9	9	1	2
R:R:F195	R:R:N404	15.71	1	Yes	No	9	7	1	1
L:L:?1	R:R:F195	3.48	1	Yes	Yes	0	9	0	1
R:R:F396	R:R:V199	3.93	1	Yes	No	9	7	2	2
R:R:F396	R:R:W400	7.02	1	Yes	Yes	9	9	2	1
R:R:T399	R:R:W400	4.85	1	No	Yes	9	9	2	1
R:R:N432	R:R:T399	11.7	1	Yes	No	9	9	2	2
R:R:N432	R:R:W400	10.17	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W400	30.87	1	Yes	Yes	0	9	0	1
R:R:N404	R:R:Y403	9.3	1	No	No	7	8	1	1
L:L:?1	R:R:Y403	15.89	1	Yes	No	0	8	0	1
L:L:?1	R:R:N404	3.92	1	Yes	No	0	7	0	1
R:R:Y426	R:R:Y430	10.92	1	Yes	Yes	7	9	1	1
L:L:?1	R:R:Y426	13.38	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C429	5.66	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y430	6.69	1	Yes	Yes	0	9	0	1
R:R:N108	R:R:V111	2.96	1	Yes	No	9	9	1	2
R:R:A401	R:R:F195	2.77	0	No	Yes	7	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y426	R:R:Y80	15.89	1	Yes	No	7	8	2	1
R:R:W427	R:R:Y80	3.86	0	No	No	9	8	2	1
R:R:Y80	W:W:?2	6.03	0	No	Yes	8	0	1	0
R:R:W89	R:R:Y83	6.75	3	Yes	No	9	7	2	1
R:R:Y83	W:W:?2	6.03	0	No	Yes	7	0	1	0
R:R:T84	W:W:?2	6.5	0	No	Yes	7	0	1	0
R:R:V171	R:R:Y177	15.14	0	No	No	4	4	2	1
R:R:Y177	W:W:?2	37.06	0	No	Yes	4	0	1	0
R:R:F181	R:R:N410	12.08	2	Yes	No	5	4	1	2
R:R:F181	R:R:W422	5.01	2	Yes	Yes	5	6	1	1
R:R:F181	W:W:?2	19.7	2	Yes	Yes	5	0	1	0
R:R:I417	R:R:N410	14.16	2	Yes	No	7	4	2	2
R:R:N410	R:R:W422	12.43	2	No	Yes	4	6	2	1
R:R:I417	R:R:W422	4.7	2	Yes	Yes	7	6	2	1
R:R:N419	R:R:W422	5.65	2	No	Yes	4	6	1	1
R:R:N419	W:W:?2	7.07	2	No	Yes	4	0	1	0
R:R:W422	W:W:?2	48.57	2	Yes	Yes	6	0	1	0
R:R:F181	R:R:V407	2.62	2	Yes	No	5	8	1	2
R:R:E175	R:R:Y83	2.24	0	Yes	No	5	7	2	1
R:R:E175	R:R:Y177	2.24	0	Yes	No	5	4	2	1
R:R:T84	R:R:V85	1.59	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OIK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	259
Number of Links	289
Number of Hubs	37
Number of Links mediated by Hubs	144
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	49245
Length Of Smallest Path	3
Average Path Length	13.2586
Length of Longest Path	30
Minimum Path Strength	1.475
Average Path Strength	7.41656
Maximum Path Strength	42.815
Minimum Path Correlation	0.7
Average Path Correlation	0.930178
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	48.6271
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.3279
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • membrane-bounded organelle • cell projection • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle
Gene Ontology	Cellular Component	• symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • membrane-bounded organelle • cell projection • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell periphery • postsynapse • postsynaptic membrane • membrane • plasma membrane • plasma membrane region • synaptic membrane • intracellular vesicle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • cytoplasm • organelle membrane • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • neuron projection • cholinergic synapse • glutamatergic synapse • Golgi apparatus • endomembrane system • cell body • neuronal cell body • asymmetric synapse • axon • axon terminus • distal axon • neuron projection terminus • ciliary basal body • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • GABA-ergic synapse • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IXO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IXO
Name	4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
Synonyms	Iperoxo
Identifier
Formula	C10 H17 N2 O2
Molecular Weight	197.254
SMILES
PubChem	10104167
Formal Charge	1
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	0


Code	2CU
PDB Residues	W:W:?2
Environment Details	Open EMBL-EBI Page
Code	2CU
Name	3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
Synonyms	LY2119620 positive allosteric modulator of M2/M4 receptor
Identifier
Formula	C19 H24 Cl N5 O3 S
Molecular Weight	437.944
SMILES
PubChem	57664406
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08172
Sequence	>6OIK_nogp_Chain_R T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N R H L Q T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G Y W P L G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P V K R T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G V R T V E D G E C Y I Q F F S N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C A P C I P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K K T F K H L L M C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8PM2	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	10.1038/s41422-024-01044-w
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	10.1038/s41422-023-00779-2
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	PubChem 57664406	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	PubChem 57664406		3.16	2023-01-25	10.1038/s41467-022-35726-z
	7T90	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.32	2023-01-25	10.1038/s41467-022-35726-z
	7T90 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.32	2023-01-25	10.1038/s41467-022-35726-z
	7T8X	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.21	2023-01-25	10.1038/s41467-022-35726-z
	7T8X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.21	2023-01-25	10.1038/s41467-022-35726-z
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	10.1016/j.cell.2022.09.041
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	10.1038/s41586-022-05173-3
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	PubChem 644078	Gs/β1/γ2	2.9	2022-08-03	10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	PubChem 644078		2.9	2022-08-03	10.1038/s41586-022-05159-1
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	10.1002/anie.202200269
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	10.1021/acsptsci.9b00080
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	10.1126/science.aaw5188
	5ZKC	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	2.3	2018-11-21	10.1038/s41589-018-0152-y
	5ZKB	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	AF-DX 384	-	-	2.95	2018-11-21	10.1038/s41589-018-0152-y
	5ZK8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	3	2018-11-21	10.1038/s41589-018-0152-y
	5ZK3	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	2.6	2018-11-21	10.1038/s41589-018-0152-y
	5YC8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	2.5	2018-11-21	10.1038/s41589-018-0152-y
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	10.1038/s41467-017-00630-4
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	10.1038/nature12735
	4MQS	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	-	-	3.5	2013-11-27	10.1038/nature12735
	3UON	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	3	2012-02-01	10.1038/nature10753

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