psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E22	R:R:I26	4.1	No	No	0	5	6
2	R:R:L28	R:R:V24	4.47	No	No	0	4	6
3	R:R:T81	R:R:V27	4.76	No	No	0	7	5
4	R:R:A30	R:R:T81	5.03	No	No	0	7	7
5	R:R:L33	R:R:S32	3	No	No	0	6	5
6	R:R:M77	R:R:S34	7.67	No	No	0	9	8
7	R:R:I38	R:R:T37	3.04	Yes	Yes	0	7	8
8	R:R:N41	R:R:T37	2.92	No	Yes	0	9	8
9	R:R:S433	R:R:T37	4.8	No	Yes	0	9	8
10	R:R:T37	R:R:T434	3.14	Yes	No	0	8	7
11	R:R:I38	R:R:I42	2.94	Yes	No	0	7	6
12	R:R:I38	R:R:L70	5.71	Yes	No	0	7	8
13	R:R:I38	R:R:V74	3.07	Yes	No	0	7	5
14	R:R:I39	R:R:L43	2.85	No	No	0	5	8
15	R:R:A66	R:R:N41	3.13	No	No	0	9	9
16	R:R:N41	R:R:P437	4.89	No	No	0	9	9
17	R:R:F451	R:R:L43	3.65	No	No	0	9	8
18	R:R:L62	R:R:V44	2.98	No	No	0	8	9
19	R:R:A66	R:R:M45	3.22	No	No	0	9	7
20	R:R:L454	R:R:V46	2.98	No	No	0	7	6
21	R:R:S47	R:R:T450	3.2	No	No	0	9	8
22	R:R:F451	R:R:S47	5.28	No	No	0	9	9
23	R:R:L454	R:R:S47	3	No	No	0	7	9
24	R:R:I48	R:R:N59	7.08	No	Yes	3	8	9
25	R:R:I48	R:R:L62	4.28	No	No	3	8	8
26	R:R:F447	R:R:I48	5.02	Yes	No	3	9	8
27	R:R:H453	R:R:V50	2.77	No	No	0	6	7
28	R:R:L454	R:R:V50	4.47	No	No	0	7	7
29	R:R:H53	R:R:N51	10.2	No	No	0	6	8
30	R:R:L54	R:R:N51	10.98	Yes	No	0	9	8
31	R:R:Q55	R:R:R52	9.35	No	No	0	8	8
32	R:R:L54	R:R:N59	2.75	Yes	Yes	3	9	9
33	R:R:L54	R:R:T446	2.95	Yes	No	0	9	7
34	R:R:F447	R:R:L54	9.74	Yes	Yes	3	9	9
35	R:R:L54	R:R:T450	5.9	Yes	No	0	9	8
36	R:R:N58	R:R:T56	2.92	No	No	0	9	8
37	R:R:N59	R:R:T56	7.31	Yes	No	0	9	8
38	R:R:R135	R:R:V57	6.54	Yes	No	0	8	7
39	R:R:D120	R:R:N58	2.69	No	No	0	9	9
40	R:R:N58	R:R:R135	6.03	No	Yes	0	9	8
41	R:R:F447	R:R:N59	7.25	Yes	Yes	3	9	9
42	R:R:T137	R:R:Y60	6.24	No	No	0	5	8
43	R:R:F61	R:R:I116	8.79	Yes	No	0	8	8
44	R:R:F61	R:R:I117	3.77	Yes	Yes	1	8	9
45	R:R:D120	R:R:F61	10.75	No	Yes	1	9	8
46	R:R:A140	R:R:F61	2.77	No	Yes	0	8	8
47	R:R:F61	R:R:M143	3.73	Yes	No	0	8	8
48	R:R:F447	R:R:L62	3.65	Yes	No	3	9	8
49	R:R:C67	R:R:F63	8.38	No	No	0	7	7
50	R:R:N113	R:R:S64	5.96	No	No	0	9	9
51	R:R:I144	R:R:S64	9.29	No	No	0	9	9
52	R:R:D69	R:R:L65	5.43	Yes	Yes	1	9	9
53	R:R:L65	R:R:N113	5.49	Yes	No	0	9	9
54	R:R:L114	R:R:L65	4.15	No	Yes	1	9	9
55	R:R:L65	R:R:N436	8.24	Yes	Yes	1	9	9
56	R:R:D69	R:R:S110	2.94	Yes	No	0	9	9
57	R:R:D69	R:R:S433	11.78	Yes	No	0	9	9
58	R:R:D69	R:R:N436	8.08	Yes	Yes	1	9	9
59	R:R:I71	R:R:V106	3.07	No	No	0	8	7
60	R:R:D103	R:R:I72	2.8	Yes	Yes	0	9	8
61	R:R:I72	R:R:V106	7.68	Yes	No	0	8	7
62	R:R:I72	R:R:S107	3.1	Yes	No	0	8	8
63	R:R:I72	R:R:S433	3.1	Yes	No	0	8	9
64	R:R:N78	R:R:V74	2.96	No	No	0	9	5
65	R:R:F75	R:R:L79	10.96	No	No	0	5	7
66	R:R:D103	R:R:S76	8.83	Yes	No	1	9	8
67	R:R:S76	R:R:Y430	5.09	No	Yes	1	8	9
68	R:R:M77	R:R:Y430	5.99	No	Yes	0	9	9
69	R:R:L79	R:R:W99	5.69	No	No	0	7	7
70	R:R:Y80	R:R:Y83	8.94	Yes	No	0	8	7
71	R:R:T84	R:R:Y80	6.24	Yes	Yes	1	7	8
72	R:R:W99	R:R:Y80	6.75	No	Yes	0	7	8
73	R:R:T423	R:R:Y80	7.49	No	Yes	1	6	8
74	R:R:Y426	R:R:Y80	6.95	Yes	Yes	1	7	8
75	R:R:W427	R:R:Y80	4.82	Yes	Yes	1	9	8
76	R:R:Y430	R:R:Y80	2.98	Yes	Yes	1	9	8
77	R:R:T81	R:R:T84	4.71	No	Yes	0	7	7
78	R:R:E175	R:R:Y83	6.73	No	No	0	5	7
79	R:R:T84	R:R:V85	3.17	Yes	No	0	7	6
80	R:R:T84	R:R:W427	8.49	Yes	Yes	1	7	9
81	R:R:G87	R:R:I86	3.53	No	No	0	6	6
82	R:R:I86	R:R:P90	3.39	No	No	0	6	4
83	R:R:W89	R:R:Y88	11.58	Yes	No	0	9	4
84	R:R:G92	R:R:W89	9.85	No	Yes	2	7	9
85	R:R:P93	R:R:W89	2.7	No	Yes	2	4	9
86	R:R:D173	R:R:W89	4.47	No	Yes	0	3	9
87	R:R:G174	R:R:W89	5.63	No	Yes	0	3	9
88	R:R:L91	R:R:V95	7.45	No	No	0	8	6
89	R:R:G92	R:R:P93	4.06	No	No	2	7	4
90	R:R:P93	R:R:R169	4.32	No	Yes	2	4	8
91	R:R:C176	R:R:C96	7.28	No	No	0	9	9
92	R:R:D97	R:R:Q163	7.83	No	Yes	2	7	7
93	R:R:D97	R:R:R169	11.91	No	Yes	2	7	8
94	R:R:L100	R:R:W99	4.56	No	No	0	7	7
95	R:R:I178	R:R:L100	8.56	Yes	No	0	7	7
96	R:R:A101	R:R:I159	3.25	No	No	0	8	8
97	R:R:D103	R:R:Y430	10.34	Yes	Yes	1	9	9
98	L:L:?1	R:R:D103	5.84	Yes	Yes	1	0	9
99	R:R:W155	R:R:Y104	12.54	Yes	Yes	1	8	8
100	R:R:I178	R:R:Y104	8.46	Yes	Yes	0	7	8
101	R:R:F181	R:R:Y104	7.22	No	Yes	1	5	8
102	R:R:Y104	R:R:Y403	3.97	Yes	Yes	1	8	8
103	R:R:Y104	R:R:Y426	2.98	Yes	Yes	1	8	7
104	L:L:?1	R:R:Y104	7.06	Yes	Yes	1	0	8
105	R:R:S151	R:R:V105	3.23	Yes	No	6	9	8
106	R:R:F152	R:R:V105	6.55	No	No	6	5	8
107	L:L:?1	R:R:S107	7.75	Yes	No	0	0	8
108	R:R:M112	R:R:N108	4.21	No	Yes	0	8	9
109	R:R:N108	R:R:S151	4.47	Yes	Yes	0	9	9
110	R:R:L154	R:R:N108	5.49	No	Yes	0	8	9
111	R:R:N108	R:R:W155	7.91	Yes	Yes	0	9	8
112	R:R:A109	R:R:W148	7.78	No	No	0	8	9
113	R:R:A109	R:R:S151	3.42	No	Yes	0	8	9
114	R:R:P198	R:R:V111	3.53	No	No	0	9	9
115	R:R:V111	R:R:W400	3.68	No	Yes	0	9	9
116	R:R:L114	R:R:N436	8.24	No	Yes	1	9	9
117	R:R:L114	R:R:Y440	4.69	No	Yes	1	9	9
118	R:R:F119	R:R:L115	6.09	No	No	0	7	7
119	R:R:I201	R:R:L115	2.85	No	No	0	7	7
120	R:R:D120	R:R:I117	2.8	No	Yes	1	9	9
121	R:R:I117	R:R:R121	5.01	Yes	No	1	9	9
122	R:R:I117	R:R:Y440	6.04	Yes	Yes	1	9	9
123	R:R:M202	R:R:S118	4.6	No	No	0	9	9
124	R:R:L205	R:R:S118	6.01	No	No	0	8	9
125	R:R:S118	R:R:Y206	10.17	No	Yes	0	9	9
126	R:R:F119	R:R:L205	3.65	No	No	0	7	8
127	R:R:R121	R:R:Y440	7.2	No	Yes	1	9	9
128	R:R:F123	R:R:Y122	5.16	No	Yes	0	6	9
129	R:R:T126	R:R:Y122	11.24	No	Yes	0	8	9
130	R:R:L205	R:R:Y122	14.07	No	Yes	0	8	9
131	R:R:H208	R:R:Y122	4.36	No	Yes	0	6	9
132	R:R:I209	R:R:Y122	6.04	No	Yes	0	9	9
133	R:R:F123	R:R:Y131	14.44	No	Yes	0	6	9
134	R:R:C124	R:R:Y131	5.38	No	Yes	5	8	9
135	R:R:C124	R:R:R135	4.18	No	Yes	5	8	8
136	R:R:K127	R:R:T130	4.5	No	No	0	7	6
137	R:R:P132	R:R:Y131	5.56	No	Yes	0	7	9
138	R:R:R135	R:R:Y131	15.43	Yes	Yes	5	8	9
139	R:R:F152	R:R:W148	3.01	No	No	0	5	9
140	R:R:F152	R:R:S151	3.96	No	Yes	6	5	9
141	R:R:T190	R:R:W155	10.92	No	Yes	0	9	8
142	L:L:?1	R:R:W155	3.92	Yes	Yes	1	0	8
143	R:R:A158	R:R:F180	5.55	No	Yes	0	7	7
144	R:R:I159	R:R:I178	11.77	No	Yes	0	8	7
145	R:R:I165	R:R:W162	19.97	No	No	0	5	6
146	R:R:Q179	R:R:W162	6.57	Yes	No	0	7	6
147	R:R:F180	R:R:W162	7.02	Yes	No	0	7	6
148	R:R:Q163	R:R:R169	7.01	Yes	Yes	2	7	8
149	R:R:Q163	R:R:Q179	6.4	Yes	Yes	0	7	7
150	R:R:R169	R:R:V171	9.15	Yes	No	0	8	4
151	R:R:Q179	R:R:T170	8.5	Yes	No	0	7	5
152	R:R:V171	R:R:Y177	10.09	No	No	0	4	4
153	R:R:Q179	R:R:V171	2.87	Yes	No	0	7	4
154	R:R:E172	R:R:E175	8.88	No	No	0	1	5
155	R:R:E172	R:R:Y177	13.47	No	No	0	1	4
156	R:R:F180	R:R:I178	3.77	Yes	Yes	0	7	7
157	R:R:F180	R:R:N183	15.71	Yes	No	7	7	7
158	R:R:F180	R:R:V186	7.87	Yes	No	7	7	8
159	R:R:F181	R:R:T187	3.89	No	No	0	5	8
160	R:R:F181	R:R:Y403	5.16	No	Yes	1	5	8
161	R:R:N183	R:R:V186	4.43	No	No	7	7	8
162	R:R:N183	R:R:T187	10.24	No	No	0	7	8
163	R:R:T187	R:R:T411	3.14	No	No	0	8	7
164	R:R:F188	R:R:L408	9.74	No	No	0	7	7
165	R:R:F188	R:R:T411	11.67	No	No	0	7	7
166	R:R:I192	R:R:Y196	8.46	No	No	0	7	8
167	R:R:F195	R:R:Y196	7.22	Yes	No	0	9	8
168	R:R:F195	R:R:V199	5.24	Yes	No	1	9	7
169	R:R:F195	R:R:F396	3.22	Yes	Yes	1	9	9
170	R:R:F195	R:R:W400	5.01	Yes	Yes	1	9	9
171	R:R:F195	R:R:N404	20.54	Yes	No	0	9	7
172	R:R:L408	R:R:Y196	5.86	No	No	0	7	8
173	R:R:F396	R:R:V199	3.93	Yes	No	1	9	7
174	R:R:I397	R:R:V199	3.07	No	No	0	7	7
175	R:R:L393	R:R:M202	2.83	Yes	No	0	8	9
176	R:R:L393	R:R:T203	2.95	Yes	No	0	8	6
177	R:R:H208	R:R:V204	2.77	No	No	0	6	5
178	R:R:I209	R:R:Y206	3.63	No	Yes	4	9	9
179	R:R:I389	R:R:Y206	7.25	Yes	Yes	4	9	9
180	R:R:L393	R:R:Y206	7.03	Yes	Yes	4	8	9
181	R:R:H208	R:R:W207	12.7	No	No	0	6	4
182	R:R:R211	R:R:W207	16.99	No	No	0	5	4
183	R:R:I209	R:R:I389	2.94	No	Yes	4	9	9
184	R:R:E382	R:R:S210	2.87	Yes	No	8	9	8
185	R:R:S210	R:R:T386	6.4	No	No	8	8	8
186	R:R:E382	R:R:S213	2.87	Yes	No	0	9	8
187	R:R:S213	R:R:V385	9.7	No	No	0	8	8
188	R:R:K214	R:R:S380	4.59	No	No	0	7	5
189	R:R:E382	R:R:K214	16.2	Yes	No	0	9	7
190	R:R:K218	R:R:S215	4.59	No	No	0	6	6
191	R:R:E382	R:R:T386	2.82	Yes	No	8	9	8
192	R:R:K383	R:R:R387	6.19	No	No	0	7	8
193	R:R:I389	R:R:V385	3.07	Yes	No	0	9	8
194	R:R:I389	R:R:L393	2.85	Yes	Yes	4	9	8
195	R:R:C439	R:R:I392	3.27	Yes	No	1	9	9
196	R:R:I392	R:R:Y440	3.63	No	Yes	1	9	9
197	R:R:I398	R:R:L394	2.85	No	No	0	5	7
198	R:R:F396	R:R:W400	6.01	Yes	Yes	1	9	9
199	R:R:F396	R:R:N432	4.83	Yes	No	1	9	9
200	R:R:T399	R:R:W400	6.06	No	Yes	0	9	9
201	R:R:N432	R:R:W400	5.65	No	Yes	1	9	9
202	L:L:?1	R:R:W400	9.8	Yes	Yes	1	0	9
203	R:R:V407	R:R:Y403	8.83	No	Yes	0	8	8
204	R:R:Y403	R:R:Y426	3.97	Yes	Yes	1	8	7
205	R:R:C429	R:R:Y403	4.03	No	Yes	1	8	8
206	L:L:?1	R:R:Y403	4.03	Yes	Yes	1	0	8
207	R:R:I409	R:R:M406	2.92	No	Yes	0	7	7
208	R:R:M406	R:R:W422	4.65	Yes	No	0	7	6
209	R:R:L408	R:R:V407	2.98	No	No	0	7	8
210	R:R:N410	R:R:T411	4.39	No	No	0	4	7
211	R:R:N410	R:R:W422	4.52	No	No	0	4	6
212	R:R:C413	R:R:F412	8.38	No	No	0	7	7
213	R:R:P418	R:R:T420	3.5	No	No	0	7	4
214	R:R:T420	R:R:V421	3.17	No	No	0	4	5
215	R:R:W422	R:R:Y426	8.68	No	Yes	0	6	7
216	R:R:T423	R:R:W427	14.55	No	Yes	1	6	9
217	R:R:I424	R:R:W427	7.05	No	Yes	0	5	9
218	R:R:Y426	R:R:Y430	2.98	Yes	Yes	1	7	9
219	L:L:?1	R:R:Y426	8.07	Yes	Yes	1	0	7
220	R:R:W427	R:R:Y430	3.86	Yes	Yes	1	9	9
221	L:L:?1	R:R:C429	6.82	Yes	No	1	0	8
222	L:L:?1	R:R:Y430	15.12	Yes	Yes	1	0	9
223	R:R:I431	R:R:I435	2.94	No	No	0	6	6
224	R:R:N432	R:R:N436	9.54	No	Yes	1	9	9
225	R:R:A438	R:R:L442	3.15	No	No	0	7	7
226	R:R:C439	R:R:Y440	2.69	Yes	Yes	1	9	9
227	R:R:A441	R:R:F447	5.55	No	Yes	0	8	9
228	R:R:K448	R:R:L442	7.05	No	No	0	9	7
229	R:R:N444	R:R:T446	11.7	No	No	0	9	7
230	R:R:F447	R:R:N444	9.67	Yes	No	0	9	9
231	R:R:A445	R:R:K449	3.21	No	No	0	5	6
232	R:R:A68	R:R:W148	2.59	No	No	0	9	9
233	R:R:F63	R:R:M45	2.49	No	No	0	7	7
234	R:R:M139	R:R:R135	2.48	No	Yes	0	8	8
235	R:R:F75	R:R:L102	2.44	No	No	0	5	6
236	R:R:F161	R:R:L160	2.44	No	No	0	7	6
237	R:R:I86	R:R:Y83	2.42	No	No	0	6	7
238	R:R:A30	R:R:G31	1.95	No	No	0	7	4
239	R:R:A140	R:R:G141	1.95	No	No	0	8	4
240	R:R:A156	R:R:P157	1.87	No	No	0	6	8
241	R:R:A401	R:R:P402	1.87	No	No	0	7	9
242	R:R:A395	R:R:C439	1.81	No	Yes	0	8	9
243	R:R:G73	R:R:I38	1.76	No	Yes	0	8	7
244	R:R:G73	R:R:I72	1.76	No	Yes	0	8	8
245	R:R:G189	R:R:I192	1.76	No	No	0	6	7
246	R:R:G425	R:R:M406	1.75	No	Yes	0	6	7
247	R:R:G40	R:R:L43	1.71	No	No	0	9	8
248	R:R:A156	R:R:V105	1.7	No	No	0	6	8
249	R:R:A191	R:R:V407	1.7	No	No	0	8	8
250	R:R:C443	R:R:T388	1.69	No	No	0	9	9
251	R:R:I417	R:R:P418	1.69	No	No	0	7	7
252	R:R:A212	R:R:T126	1.68	No	No	0	7	8
253	R:R:M406	R:R:P402	1.68	Yes	No	0	7	9
254	R:R:K127	R:R:P128	1.67	No	No	0	7	9
255	R:R:K383	R:R:P379	1.67	No	No	0	7	4
256	R:R:L82	R:R:P90	1.64	No	No	0	5	4
257	R:R:L129	R:R:P128	1.64	No	No	0	7	9
258	R:R:L197	R:R:P198	1.64	No	No	0	7	9
259	R:R:L428	R:R:P402	1.64	No	No	0	8	9
260	R:R:C439	R:R:I435	1.64	Yes	No	0	9	6
261	R:R:A147	R:R:I116	1.62	No	No	0	8	8
262	R:R:T434	R:R:V36	1.59	No	No	0	7	5
263	R:R:T137	R:R:V57	1.59	No	No	0	5	7
264	R:R:A101	R:R:L160	1.58	No	No	0	8	6
265	R:R:A194	R:R:L154	1.58	No	No	0	8	8
266	R:R:C96	R:R:D97	1.56	No	No	0	9	7
267	R:R:I217	R:R:S215	1.55	No	No	0	5	6
268	R:R:I26	R:R:V85	1.54	No	No	0	6	6
269	R:R:I200	R:R:V204	1.54	No	No	0	5	5
270	R:R:I392	R:R:T388	1.52	No	No	0	9	9
271	R:R:M406	R:R:V421	1.52	Yes	No	0	7	5
272	R:R:M139	R:R:T136	1.51	No	No	0	8	9
273	R:R:K127	R:R:T126	1.5	No	No	0	7	8
274	R:R:K138	R:R:T136	1.5	No	No	0	5	9
275	R:R:L33	R:R:T434	1.47	No	No	0	6	7
276	R:R:L390	R:R:T386	1.47	No	No	0	7	8
277	R:R:C457	R:R:H453	1.47	No	No	0	6	6
278	R:R:K138	R:R:M142	1.44	No	No	0	5	4
279	R:R:M142	R:R:M143	1.44	No	No	0	4	8
280	R:R:E22	R:R:V23	1.43	No	No	0	5	4
281	R:R:L150	R:R:M112	1.41	No	No	0	6	8
282	R:R:A185	R:R:F188	1.39	No	No	0	4	7
283	R:R:L390	R:R:L394	1.38	No	No	0	7	7
284	R:R:R381	R:R:S215	1.32	No	No	0	7	6
285	R:R:R381	R:R:S380	1.32	No	No	0	7	5
286	R:R:K214	R:R:R216	1.24	No	No	0	7	8
287	R:R:F164	R:R:Q163	1.17	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T37	3.475	4	0	8
2	R:R:I38	3.304	5	0	7
3	R:R:L54	6.464	5	3	9
4	R:R:N59	6.0975	4	3	9
5	R:R:F61	5.962	5	1	8
6	R:R:L65	5.8275	4	1	9
7	R:R:D69	7.0575	4	1	9
8	R:R:I72	3.688	5	0	8
9	R:R:Y80	6.31	7	1	8
10	R:R:T84	5.6525	4	1	7
11	R:R:W89	6.846	5	2	9
12	R:R:D103	6.9525	4	1	9
13	R:R:Y104	7.03833	6	1	8
14	R:R:N108	5.52	4	0	9
15	R:R:I117	4.405	4	1	9
16	R:R:Y122	8.174	5	0	9
17	R:R:Y131	10.2025	4	5	9
18	R:R:R135	6.932	5	5	8
19	R:R:S151	3.77	4	6	9
20	R:R:W155	8.8225	4	1	8
21	R:R:Q163	5.6025	4	2	7
22	R:R:R169	8.0975	4	2	8
23	R:R:I178	8.14	4	0	7
24	R:R:Q179	6.085	4	0	7
25	R:R:F180	7.984	5	7	7
26	R:R:F195	8.246	5	1	9
27	R:R:Y206	7.02	4	4	9
28	R:R:E382	6.19	4	8	9
29	R:R:I389	4.0275	4	4	9
30	R:R:L393	3.915	4	4	8
31	R:R:F396	4.4975	4	1	9
32	R:R:W400	6.035	6	1	9
33	R:R:Y403	4.99833	6	1	8
34	R:R:M406	2.504	5	0	7
35	R:R:Y426	5.605	6	1	7
36	R:R:W427	7.754	5	1	9
37	R:R:Y430	6.62286	7	1	9
38	R:R:N436	8.525	4	1	9
39	R:R:C439	2.3525	4	1	9
40	R:R:Y440	4.85	5	1	9
41	R:R:F447	6.81333	6	3	9
42	L:L:?1	7.60111	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T84	R:R:V85	10.7675	3.17	Yes	No	0	7	6
2	R:R:T81	R:R:T84	10.7536	4.71	No	Yes	0	7	7
3	R:R:T84	R:R:Y80	17.0493	6.24	Yes	Yes	1	7	8
4	R:R:Y430	R:R:Y80	18.9334	2.98	Yes	Yes	1	9	8
5	R:R:D103	R:R:I72	19.1603	2.8	Yes	Yes	0	9	8
6	R:R:I72	R:R:S433	23.2062	3.1	Yes	No	0	8	9
7	R:R:S433	R:R:T37	28.7983	4.8	No	Yes	0	9	8
8	R:R:N41	R:R:T37	13.4108	2.92	No	Yes	0	9	8
9	R:R:Y426	R:R:Y80	21.4332	6.95	Yes	Yes	1	7	8
10	L:L:?1	R:R:Y426	26.1504	8.07	Yes	Yes	1	0	7
11	L:L:?1	R:R:W400	79.7334	9.8	Yes	Yes	1	0	9
12	R:R:N432	R:R:W400	75.0301	5.65	No	Yes	1	9	9
13	R:R:N432	R:R:N436	81.0666	9.54	No	Yes	1	9	9
14	R:R:L114	R:R:N436	87.1586	8.24	No	Yes	1	9	9
15	R:R:L114	R:R:Y440	100	4.69	No	Yes	1	9	9
16	R:R:I117	R:R:Y440	93.7089	6.04	Yes	Yes	1	9	9
17	R:R:D120	R:R:I117	83.6728	2.8	No	Yes	1	9	9
18	R:R:D120	R:R:N58	85.1403	2.69	No	No	0	9	9
19	R:R:N58	R:R:T56	34.0154	2.92	No	No	0	9	8
20	R:R:N59	R:R:T56	32.7423	7.31	Yes	No	0	9	8
21	R:R:L54	R:R:N59	20.5768	2.75	Yes	Yes	3	9	9
22	R:R:L54	R:R:T450	15.5402	5.9	Yes	No	0	9	8
23	R:R:S47	R:R:T450	14.332	3.2	No	No	0	9	8
24	L:L:?1	R:R:Y430	25.0671	15.12	Yes	Yes	1	0	9
25	R:R:N58	R:R:R135	61.985	6.03	No	Yes	0	9	8
26	R:R:D69	R:R:S433	26.2244	11.78	Yes	No	0	9	9
27	R:R:D69	R:R:L65	12.8553	5.43	Yes	Yes	1	9	9
28	L:L:?1	R:R:S107	11.1008	7.75	Yes	No	0	0	8
29	R:R:Y80	R:R:Y83	17.1975	8.94	Yes	No	0	8	7
30	R:R:R169	R:R:V171	10.3787	9.15	Yes	No	0	8	4
31	R:R:P93	R:R:R169	15.1606	4.32	No	Yes	2	4	8
32	R:R:P93	R:R:W89	10.1241	2.7	No	Yes	2	4	9
33	R:R:Q163	R:R:Q179	13.7256	6.4	Yes	Yes	0	7	7
34	R:R:F180	R:R:I178	30.5527	3.77	Yes	Yes	0	7	7
35	R:R:F180	R:R:W162	27.303	7.02	Yes	No	0	7	6
36	R:R:Q179	R:R:W162	24.9699	6.57	Yes	No	0	7	6
37	R:R:I178	R:R:Y104	35.094	8.46	Yes	Yes	0	7	8
38	L:L:?1	R:R:W155	19.5584	3.92	Yes	Yes	1	0	8
39	R:R:N108	R:R:W155	23.7432	7.91	Yes	Yes	0	9	8
40	R:R:N108	R:R:S151	16.0587	4.47	Yes	Yes	0	9	9
41	R:R:R135	R:R:Y131	54.6848	15.43	Yes	Yes	5	8	9
42	R:R:F123	R:R:Y131	52.6618	14.44	No	Yes	0	6	9
43	R:R:F123	R:R:Y122	51.5369	5.16	No	Yes	0	6	9
44	R:R:I209	R:R:Y122	29.5806	6.04	No	Yes	0	9	9
45	R:R:W422	R:R:Y426	18.0539	8.68	No	Yes	0	6	7
46	R:R:F195	R:R:W400	10.3416	5.01	Yes	Yes	1	9	9
47	R:R:I209	R:R:I389	24.2015	2.94	No	Yes	4	9	9
48	R:R:I389	R:R:V385	20.9055	3.07	Yes	No	0	9	8
49	R:R:S213	R:R:V385	19.7019	9.7	No	No	0	8	8
50	R:R:E382	R:R:S213	18.3177	2.87	Yes	No	0	9	8
51	R:R:M406	R:R:W422	14.8875	4.65	Yes	No	0	7	6
52	R:R:L114	R:R:L65	13.4663	4.15	No	Yes	1	9	9
53	R:R:D69	R:R:N436	13.9385	8.08	Yes	Yes	1	9	9
54	R:R:I72	R:R:S107	10.9342	3.1	Yes	No	0	8	8
55	L:L:?1	R:R:D103	11.573	5.84	Yes	Yes	1	0	9
56	L:L:?1	R:R:Y104	30.849	7.06	Yes	Yes	1	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D103	R:R:I72	2.8	1	Yes	Yes	9	8	1	2
R:R:I72	R:R:S107	3.1	0	Yes	No	8	8	2	1
R:R:D103	R:R:S76	8.83	1	Yes	No	9	8	1	2
R:R:S76	R:R:Y430	5.09	1	No	Yes	8	9	2	1
R:R:M77	R:R:Y430	5.99	0	No	Yes	9	9	2	1
R:R:Y426	R:R:Y80	6.95	1	Yes	Yes	7	8	1	2
R:R:W427	R:R:Y80	4.82	1	Yes	Yes	9	8	2	2
R:R:Y430	R:R:Y80	2.98	1	Yes	Yes	9	8	1	2
R:R:D103	R:R:Y430	10.34	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:D103	5.84	1	Yes	Yes	0	9	0	1
R:R:W155	R:R:Y104	12.54	1	Yes	Yes	8	8	1	1
R:R:I178	R:R:Y104	8.46	0	Yes	Yes	7	8	2	1
R:R:F181	R:R:Y104	7.22	1	No	Yes	5	8	2	1
R:R:Y104	R:R:Y403	3.97	1	Yes	Yes	8	8	1	1
R:R:Y104	R:R:Y426	2.98	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y104	7.06	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S107	7.75	1	Yes	No	0	8	0	1
R:R:N108	R:R:W155	7.91	0	Yes	Yes	9	8	2	1
R:R:V111	R:R:W400	3.68	0	No	Yes	9	9	2	1
R:R:T190	R:R:W155	10.92	0	No	Yes	9	8	2	1
L:L:?1	R:R:W155	3.92	1	Yes	Yes	0	8	0	1
R:R:F181	R:R:Y403	5.16	1	No	Yes	5	8	2	1
R:R:F195	R:R:F396	3.22	1	Yes	Yes	9	9	2	2
R:R:F195	R:R:W400	5.01	1	Yes	Yes	9	9	2	1
R:R:F396	R:R:W400	6.01	1	Yes	Yes	9	9	2	1
R:R:F396	R:R:N432	4.83	1	Yes	No	9	9	2	2
R:R:T399	R:R:W400	6.06	0	No	Yes	9	9	2	1
R:R:N432	R:R:W400	5.65	1	No	Yes	9	9	2	1
L:L:?1	R:R:W400	9.8	1	Yes	Yes	0	9	0	1
R:R:V407	R:R:Y403	8.83	0	No	Yes	8	8	2	1
R:R:Y403	R:R:Y426	3.97	1	Yes	Yes	8	7	1	1
R:R:C429	R:R:Y403	4.03	1	No	Yes	8	8	1	1
L:L:?1	R:R:Y403	4.03	1	Yes	Yes	0	8	0	1
R:R:W422	R:R:Y426	8.68	0	No	Yes	6	7	2	1
R:R:Y426	R:R:Y430	2.98	1	Yes	Yes	7	9	1	1
L:L:?1	R:R:Y426	8.07	1	Yes	Yes	0	7	0	1
R:R:W427	R:R:Y430	3.86	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:C429	6.82	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y430	15.12	1	Yes	Yes	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T90_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	248
Number of Links	287
Number of Hubs	42
Number of Links mediated by Hubs	158
Number of Communities	8
Number of Nodes involved in Communities	57
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	44309
Length Of Smallest Path	3
Average Path Length	13.1971
Length of Longest Path	33
Minimum Path Strength	1.32
Average Path Strength	6.08429
Maximum Path Strength	14.935
Minimum Path Correlation	0.7
Average Path Correlation	0.929355
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	53.3824
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.4203
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACH
Name	Acetylcholine
Synonyms	Acetylcholine chloride Acetylcholine ACh O-Acetylcholine Choline acetate
Identifier
Formula	C7 H16 N O2
Molecular Weight	146.207
SMILES
PubChem	187
Formal Charge	1
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	25
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08172
Sequence	>7T90_nogp_Chain_R E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N R H L Q T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G Y W P L G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P V K R T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G V R T V E D G E C Y I Q F F S N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C A C I P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K K T F K H L L M C H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3UON	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	3	2012-02-01	doi.org/10.1038/nature10753
	4MQS	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	-	-	3.5	2013-11-27	doi.org/10.1038/nature12735
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5YC8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-methyl-Scopolamine	-	-	2.5	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK3	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	2.6	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-methyl-Scopolamine	-	-	3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKB	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	AF-DX 384	-	-	2.95	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKC	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-methyl-Scopolamine	-	-	2.3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T8X	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T8X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	9PEE	A	Protein	Chemokine	CCR6	Homo sapiens	-	PF-07054894; OXM2	-	3.35	2025-10-01	doi.org/10.1021/acs.jmedchem.5c01946
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	8PM2	A	Amine	Trace Amine	TA7	Mus musculus	DMCHA	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine	TA7	Mus musculus	DMCHA	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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