psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	4.67	Yes	No	1	0	9
2	L:L:?1	R:R:Y104	6.05	Yes	Yes	1	0	8
3	L:L:?1	R:R:S107	12.91	Yes	No	0	0	8
4	L:L:?1	R:R:W400	8.82	Yes	Yes	1	0	9
5	L:L:?1	R:R:Y403	13.11	Yes	Yes	1	0	8
6	L:L:?1	R:R:Y426	4.03	Yes	Yes	1	0	7
7	L:L:?1	R:R:C429	4.09	Yes	No	1	0	8
8	L:L:?1	R:R:Y430	13.11	Yes	Yes	1	0	9
9	R:R:V23	R:R:V85	3.21	No	No	1	4	6
10	R:R:A30	R:R:T81	5.03	No	No	0	7	7
11	R:R:N78	R:R:S34	5.96	No	No	0	9	8
12	R:R:I38	R:R:L35	4.28	No	No	0	7	6
13	R:R:T37	R:R:T434	6.28	No	No	0	8	7
14	R:R:D69	R:R:N41	16.16	No	No	0	9	9
15	R:R:N41	R:R:P437	4.89	No	No	0	9	9
16	R:R:F451	R:R:L43	7.31	No	No	0	9	8
17	R:R:A441	R:R:V44	3.39	No	No	0	8	9
18	R:R:F63	R:R:M45	8.71	No	Yes	0	7	7
19	R:R:A66	R:R:M45	3.22	No	Yes	0	9	7
20	R:R:C67	R:R:M45	3.24	No	Yes	0	7	7
21	R:R:S47	R:R:T450	3.2	Yes	No	0	9	8
22	R:R:I48	R:R:N59	5.66	No	Yes	2	8	9
23	R:R:F447	R:R:I48	6.28	Yes	No	2	9	8
24	R:R:K49	R:R:Q55	4.07	No	No	0	5	8
25	R:R:L54	R:R:N51	13.73	Yes	No	2	9	8
26	R:R:N51	R:R:T450	10.24	No	No	2	8	8
27	R:R:L54	R:R:T446	4.42	Yes	No	0	9	7
28	R:R:F447	R:R:L54	8.53	Yes	Yes	2	9	9
29	R:R:L54	R:R:T450	5.9	Yes	No	2	9	8
30	R:R:Q55	R:R:Y60	4.51	No	No	0	8	8
31	R:R:N58	R:R:T56	4.39	No	No	0	9	8
32	R:R:N59	R:R:T56	4.39	Yes	No	0	9	8
33	R:R:R135	R:R:V57	7.85	Yes	No	0	8	7
34	R:R:D120	R:R:N58	6.73	No	No	0	9	9
35	R:R:F447	R:R:N59	9.67	Yes	Yes	2	9	9
36	R:R:F61	R:R:I116	7.54	Yes	No	0	8	8
37	R:R:D120	R:R:F61	10.75	No	Yes	3	9	8
38	R:R:F61	R:R:R135	4.28	Yes	Yes	3	8	8
39	R:R:F61	R:R:I144	3.77	Yes	No	0	8	9
40	R:R:N113	R:R:S64	7.45	No	No	0	9	9
41	R:R:I144	R:R:S64	3.1	No	No	0	9	9
42	R:R:L65	R:R:N113	5.49	No	No	0	9	9
43	R:R:L65	R:R:N436	8.24	No	No	0	9	9
44	R:R:D69	R:R:S433	4.42	No	No	0	9	9
45	R:R:F75	R:R:I71	3.77	No	No	0	5	8
46	R:R:I72	R:R:S76	4.64	Yes	No	0	8	8
47	R:R:I72	R:R:V106	6.14	Yes	No	0	8	7
48	R:R:I72	R:R:S107	4.64	Yes	No	0	8	8
49	R:R:I72	R:R:S433	4.64	Yes	No	0	8	9
50	R:R:F75	R:R:V74	3.93	No	No	0	5	5
51	R:R:F75	R:R:L102	4.87	No	No	0	5	6
52	R:R:D103	R:R:S76	10.31	No	No	1	9	8
53	R:R:S76	R:R:Y430	6.36	No	Yes	1	8	9
54	R:R:M77	R:R:Y430	9.58	No	Yes	0	9	9
55	R:R:L79	R:R:L82	5.54	No	No	0	7	5
56	R:R:L79	R:R:W99	7.97	No	No	0	7	7
57	R:R:T84	R:R:Y80	4.99	Yes	Yes	1	7	8
58	R:R:T423	R:R:Y80	6.24	No	Yes	1	6	8
59	R:R:Y426	R:R:Y80	5.96	Yes	Yes	1	7	8
60	R:R:W427	R:R:Y80	6.75	No	Yes	1	9	8
61	R:R:Y80	W:W:?1	6.89	Yes	Yes	1	8	0
62	R:R:T81	R:R:T84	4.71	No	Yes	0	7	7
63	R:R:W89	R:R:Y83	8.68	Yes	No	0	9	7
64	R:R:Y83	W:W:?1	4.31	No	Yes	0	7	0
65	R:R:T84	R:R:V85	3.17	Yes	No	1	7	6
66	R:R:T84	R:R:W427	3.64	Yes	No	1	7	9
67	R:R:G87	R:R:I86	5.29	No	No	0	6	6
68	R:R:I86	R:R:Y88	3.63	No	No	0	6	4
69	R:R:P90	R:R:W89	5.4	No	Yes	0	4	9
70	R:R:L91	R:R:W89	3.42	No	Yes	0	8	9
71	R:R:C96	R:R:W89	9.14	No	Yes	4	9	9
72	R:R:W89	R:R:W99	7.5	Yes	No	0	9	7
73	R:R:C176	R:R:W89	14.37	No	Yes	4	9	9
74	R:R:L91	R:R:V95	5.96	No	No	0	8	6
75	R:R:G92	R:R:P93	4.06	No	No	0	7	4
76	R:R:D173	R:R:P93	3.22	No	No	0	3	4
77	R:R:V94	R:R:V95	3.21	No	No	0	4	6
78	R:R:C176	R:R:C96	7.28	No	No	4	9	9
79	R:R:D97	R:R:L160	12.21	No	No	0	7	6
80	R:R:L100	R:R:W99	3.42	No	No	0	7	7
81	R:R:A101	R:R:I159	3.25	No	No	0	8	8
82	R:R:D103	R:R:Y430	9.2	No	Yes	1	9	9
83	R:R:W155	R:R:Y104	7.72	Yes	Yes	1	8	8
84	R:R:I159	R:R:Y104	3.63	No	Yes	1	8	8
85	R:R:I178	R:R:Y104	7.25	No	Yes	0	7	8
86	R:R:Y104	R:R:Y403	5.96	Yes	Yes	1	8	8
87	R:R:Y104	R:R:Y426	8.94	Yes	Yes	1	8	7
88	R:R:N108	R:R:S151	4.47	No	No	0	9	9
89	R:R:N108	R:R:W155	10.17	No	Yes	1	9	8
90	R:R:A194	R:R:N108	4.69	No	No	1	8	9
91	R:R:A109	R:R:W148	7.78	No	No	0	8	9
92	R:R:A109	R:R:S151	3.42	No	No	0	8	9
93	R:R:P198	R:R:V111	3.53	No	No	0	9	9
94	R:R:F396	R:R:V111	3.93	No	No	0	9	9
95	R:R:V111	R:R:W400	4.9	No	Yes	0	9	9
96	R:R:L114	R:R:Y440	8.21	No	Yes	0	9	9
97	R:R:I201	R:R:L115	4.28	No	No	0	7	7
98	R:R:I117	R:R:R121	5.01	No	No	0	9	9
99	R:R:L205	R:R:S118	6.01	No	No	0	8	9
100	R:R:S118	R:R:Y206	8.9	No	Yes	0	9	9
101	R:R:F119	R:R:L205	4.87	No	No	0	7	8
102	R:R:D120	R:R:R135	9.53	No	Yes	3	9	8
103	R:R:R121	R:R:Y440	4.12	No	Yes	0	9	9
104	R:R:F123	R:R:Y122	5.16	No	Yes	0	6	9
105	R:R:T126	R:R:Y122	18.73	No	Yes	0	8	9
106	R:R:L205	R:R:Y122	5.86	No	Yes	0	8	9
107	R:R:H208	R:R:Y122	3.27	No	Yes	0	6	9
108	R:R:I209	R:R:Y122	6.04	No	Yes	0	9	9
109	R:R:F123	R:R:Y131	16.5	No	Yes	0	6	9
110	R:R:C124	R:R:Y131	5.38	No	Yes	0	8	9
111	R:R:I209	R:R:V125	4.61	No	No	0	9	8
112	R:R:L129	R:R:P128	4.93	No	No	0	7	9
113	R:R:P132	R:R:Y131	5.56	No	Yes	0	7	9
114	R:R:R135	R:R:Y131	18.52	Yes	Yes	0	8	9
115	R:R:T136	R:R:T137	3.14	No	No	0	9	5
116	R:R:G141	R:R:I144	5.29	No	No	0	4	9
117	R:R:A156	R:R:F152	4.16	No	No	0	6	5
118	R:R:L154	R:R:W155	3.42	No	Yes	0	8	8
119	R:R:I159	R:R:W155	5.87	No	Yes	1	8	8
120	R:R:T190	R:R:W155	8.49	No	Yes	0	9	8
121	R:R:A194	R:R:W155	3.89	No	Yes	1	8	8
122	R:R:F161	R:R:L160	10.96	No	No	0	7	6
123	R:R:I165	R:R:W162	10.57	No	Yes	0	5	6
124	R:R:V166	R:R:W162	7.36	No	Yes	0	4	6
125	R:R:Q179	R:R:W162	6.57	No	Yes	0	7	6
126	R:R:F180	R:R:W162	10.02	Yes	Yes	0	7	6
127	R:R:N183	R:R:W162	4.52	No	Yes	0	7	6
128	R:R:F164	R:R:Q163	4.68	No	No	0	6	7
129	R:R:Q163	R:R:R169	4.67	No	No	0	7	8
130	R:R:Q163	R:R:Q179	6.4	No	No	0	7	7
131	R:R:F181	R:R:T170	3.89	Yes	No	0	5	5
132	R:R:V171	R:R:Y177	11.36	No	Yes	0	4	4
133	R:R:Q179	R:R:V171	5.73	No	No	0	7	4
134	R:R:E172	R:R:E175	5.07	No	No	0	1	5
135	R:R:E175	R:R:Y177	12.35	No	Yes	1	5	4
136	R:R:E175	W:W:?1	5.85	No	Yes	1	5	0
137	R:R:F181	R:R:Y177	4.13	Yes	Yes	1	5	4
138	R:R:Y177	W:W:?1	23.27	Yes	Yes	1	4	0
139	R:R:F180	R:R:I178	7.54	Yes	No	0	7	7
140	R:R:F180	R:R:V186	10.49	Yes	No	0	7	8
141	R:R:F181	R:R:S182	10.57	Yes	No	0	5	6
142	R:R:F181	W:W:?1	10.75	Yes	Yes	1	5	0
143	R:R:N183	R:R:V186	11.82	No	No	0	7	8
144	R:R:A184	R:R:F188	4.16	No	Yes	0	4	7
145	R:R:F188	R:R:T187	3.89	Yes	No	5	7	8
146	R:R:T187	R:R:T411	4.71	No	No	5	8	7
147	R:R:F188	R:R:T411	6.49	Yes	No	5	7	7
148	R:R:G189	R:R:I192	3.53	No	No	0	6	7
149	R:R:F195	R:R:Y196	20.63	No	No	1	9	8
150	R:R:F195	R:R:N404	15.71	No	No	1	9	7
151	R:R:N404	R:R:Y196	3.49	No	No	1	7	8
152	R:R:L197	R:R:P198	3.28	No	No	0	7	9
153	R:R:I397	R:R:V199	4.61	No	No	0	7	7
154	R:R:M202	R:R:Y206	3.59	No	Yes	0	9	9
155	R:R:H208	R:R:V204	4.15	No	No	0	6	5
156	R:R:I389	R:R:Y206	14.51	No	Yes	0	9	9
157	R:R:L393	R:R:Y206	8.21	No	Yes	0	8	9
158	R:R:H208	R:R:W207	13.75	No	No	0	6	4
159	R:R:R211	R:R:W207	6	No	No	0	5	4
160	R:R:E382	R:R:S210	5.75	Yes	No	6	9	8
161	R:R:S210	R:R:T386	6.4	No	No	6	8	8
162	R:R:S213	R:R:V385	4.85	No	No	0	8	8
163	R:R:K383	R:R:P379	6.69	No	No	0	7	4
164	R:R:E382	R:R:T386	7.06	Yes	No	6	9	8
165	R:R:I392	R:R:Y440	12.09	No	Yes	0	9	9
166	R:R:F396	R:R:I397	3.77	No	No	0	9	7
167	R:R:T399	R:R:W400	3.64	No	Yes	1	9	9
168	R:R:L428	R:R:T399	5.9	Yes	No	0	8	9
169	R:R:N432	R:R:T399	11.7	No	No	1	9	9
170	R:R:N404	R:R:W400	4.52	No	Yes	1	7	9
171	R:R:N432	R:R:W400	9.04	No	Yes	1	9	9
172	R:R:L428	R:R:P402	3.28	Yes	No	0	8	9
173	R:R:V407	R:R:Y403	5.05	No	Yes	0	8	8
174	R:R:Y403	R:R:Y426	6.95	Yes	Yes	1	8	7
175	R:R:C429	R:R:Y403	4.03	No	Yes	1	8	8
176	R:R:N410	W:W:?1	8.08	No	Yes	0	4	0
177	R:R:I417	R:R:P418	5.08	No	No	1	7	7
178	R:R:I417	R:R:N419	4.25	No	No	0	7	4
179	R:R:I417	R:R:W422	3.52	No	Yes	1	7	6
180	R:R:P418	R:R:V421	7.07	No	No	0	7	5
181	R:R:P418	R:R:W422	10.81	No	Yes	1	7	6
182	R:R:N419	R:R:T420	13.16	No	No	0	4	4
183	R:R:W422	W:W:?1	78.71	Yes	Yes	1	6	0
184	R:R:T423	W:W:?1	10.84	No	Yes	1	6	0
185	R:R:G425	R:R:I424	3.53	No	No	0	6	5
186	R:R:Y426	R:R:Y430	8.94	Yes	Yes	1	7	9
187	R:R:Y426	W:W:?1	6.03	Yes	Yes	1	7	0
188	R:R:W427	R:R:Y430	3.86	No	Yes	1	9	9
189	R:R:I435	R:R:T434	4.56	No	No	0	6	7
190	R:R:N436	R:R:P437	6.52	No	No	0	9	9
191	R:R:A438	R:R:L442	4.73	No	No	0	7	7
192	R:R:A441	R:R:F447	4.16	No	Yes	0	8	9
193	R:R:K448	R:R:L442	4.23	No	No	0	9	7
194	R:R:F451	R:R:L442	4.87	No	No	0	9	7
195	R:R:N444	R:R:T446	7.31	No	No	0	9	7
196	R:R:F447	R:R:N444	9.67	Yes	No	0	9	9
197	R:R:C457	R:R:H453	5.9	No	No	0	6	6
198	R:R:R121	R:R:Y206	3.09	No	Yes	0	9	9
199	R:R:I26	R:R:V23	3.07	No	No	1	6	4
200	R:R:I26	R:R:V85	3.07	No	No	1	6	6
201	R:R:M77	R:R:S34	3.07	No	No	0	9	8
202	R:R:I71	R:R:V106	3.07	No	No	0	8	7
203	R:R:I200	R:R:V204	3.07	No	No	0	5	5
204	R:R:I431	R:R:T434	3.04	No	No	0	6	7
205	R:R:L28	R:R:S32	3	No	No	0	4	5
206	R:R:L393	R:R:T203	2.95	No	No	0	8	6
207	R:R:I38	R:R:I39	2.94	No	No	0	7	5
208	R:R:I409	R:R:M406	2.92	No	No	0	7	7
209	R:R:K138	R:R:M142	2.88	No	No	0	5	4
210	R:R:E382	R:R:S213	2.87	Yes	No	0	9	8
211	R:R:I201	R:R:L197	2.85	No	No	0	7	7
212	R:R:I431	R:R:L428	2.85	No	Yes	0	6	8
213	R:R:L150	R:R:M112	2.83	No	No	0	6	8
214	R:R:G92	R:R:W89	2.81	No	Yes	0	7	9
215	R:R:A140	R:R:F61	2.77	No	Yes	0	8	8
216	R:R:L390	R:R:L394	2.77	No	No	0	7	7
217	R:R:L62	R:R:N59	2.75	No	Yes	0	8	9
218	R:R:C439	R:R:Y440	2.69	No	Yes	0	9	9
219	R:R:F451	R:R:S47	2.64	No	Yes	0	9	9
220	R:R:A68	R:R:W148	2.59	No	No	0	9	9
221	R:R:F180	R:R:T187	2.59	Yes	No	0	7	8
222	R:R:F61	R:R:M143	2.49	Yes	No	0	8	8
223	R:R:F188	R:R:L408	2.44	Yes	No	0	7	7
224	R:R:I192	R:R:Y196	2.42	No	No	0	7	8
225	R:R:M406	R:R:W422	2.33	No	Yes	0	7	6
226	R:R:F63	R:R:Y60	2.06	No	No	0	7	8
227	R:R:A30	R:R:G31	1.95	No	No	0	7	4
228	R:R:P378	R:R:P379	1.95	No	No	0	5	4
229	R:R:A156	R:R:P157	1.87	No	No	0	6	8
230	R:R:A401	R:R:P402	1.87	No	No	0	7	9
231	R:R:G73	R:R:T37	1.82	No	No	0	8	8
232	R:R:A68	R:R:C67	1.81	No	No	0	9	7
233	R:R:G40	R:R:I39	1.76	No	No	0	9	5
234	R:R:G425	R:R:L428	1.71	No	Yes	0	6	8
235	R:R:A156	R:R:V105	1.7	No	No	0	6	8
236	R:R:A191	R:R:V407	1.7	No	No	0	8	8
237	R:R:I409	R:R:P415	1.69	No	No	0	7	4
238	R:R:K127	R:R:P128	1.67	No	No	0	7	9
239	R:R:S47	R:R:V46	1.62	Yes	No	0	9	6
240	R:R:A147	R:R:I116	1.62	No	No	0	8	8
241	R:R:A147	R:R:M112	1.61	No	No	0	8	8
242	R:R:V24	R:R:V27	1.6	No	No	0	6	5
243	R:R:V166	R:R:V168	1.6	No	No	0	4	3
244	R:R:T81	R:R:V27	1.59	No	No	0	7	5
245	R:R:A193	R:R:L154	1.58	No	No	0	6	8
246	R:R:A185	R:R:N183	1.56	No	No	0	4	7
247	R:R:A101	R:R:D97	1.54	No	No	0	8	7
248	R:R:I153	R:R:V149	1.54	No	No	0	5	5
249	R:R:L454	R:R:S47	1.5	No	Yes	0	7	9
250	R:R:L65	R:R:S110	1.5	No	No	0	9	9
251	R:R:K127	R:R:T126	1.5	No	No	0	7	8
252	R:R:K138	R:R:T136	1.5	No	No	0	5	9
253	R:R:L129	R:R:T130	1.47	No	No	0	7	6
254	R:R:G87	R:R:Y83	1.45	No	No	0	6	7
255	R:R:M139	R:R:M143	1.44	No	No	0	8	8
256	R:R:E382	R:R:S380	1.44	Yes	No	0	9	5
257	R:R:I38	R:R:L70	1.43	No	No	0	7	8
258	R:R:I42	R:R:L43	1.43	No	No	0	6	8
259	R:R:L70	R:R:M45	1.41	No	Yes	0	8	7
260	R:R:L455	R:R:M456	1.41	No	No	0	8	4
261	R:R:A158	R:R:F180	1.39	No	Yes	0	7	7
262	R:R:L43	R:R:L455	1.38	No	No	0	8	8
263	R:R:E382	R:R:K214	1.35	Yes	No	0	9	7
264	R:R:R381	R:R:S215	1.32	No	No	0	7	6
265	R:R:R381	R:R:S380	1.32	No	No	0	7	5
266	R:R:H53	R:R:L54	1.29	No	Yes	0	6	9
267	R:R:R387	R:R:T388	1.29	No	No	0	8	9
268	R:R:H453	R:R:L454	1.29	No	No	0	6	7
269	R:R:F152	R:R:I153	1.26	No	No	0	5	5
270	R:R:V105	R:R:W155	1.23	No	Yes	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.34875	8	1	0
2	R:R:M45	4.145	4	0	7
3	R:R:S47	2.24	4	0	9
4	R:R:L54	6.774	5	2	9
5	R:R:N59	5.6175	4	2	9
6	R:R:F61	5.26667	6	3	8
7	R:R:I72	5.015	4	0	8
8	R:R:Y80	6.166	5	1	8
9	R:R:T84	4.1275	4	1	7
10	R:R:W89	7.33143	7	4	9
11	R:R:Y104	6.59167	6	1	8
12	R:R:Y122	7.812	5	0	9
13	R:R:Y131	11.49	4	0	9
14	R:R:R135	10.045	4	3	8
15	R:R:W155	5.82714	7	1	8
16	R:R:W162	7.808	5	0	6
17	R:R:Y177	12.7775	4	1	4
18	R:R:F180	6.406	5	0	7
19	R:R:F181	7.335	4	1	5
20	R:R:F188	4.245	4	5	7
21	R:R:Y206	7.66	5	0	9
22	R:R:E382	3.694	5	6	9
23	R:R:W400	6.184	5	1	9
24	R:R:Y403	7.02	5	1	8
25	R:R:W422	23.8425	4	1	6
26	R:R:Y426	6.80833	6	1	7
27	R:R:L428	3.435	4	0	8
28	R:R:Y430	8.50833	6	1	9
29	R:R:Y440	6.7775	4	0	9
30	R:R:F447	7.662	5	2	9
31	W:W:?1	17.1922	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y426	33.4956	4.03	Yes	Yes	1	0	7
2	L:L:?1	R:R:Y104	42.2751	6.05	Yes	Yes	1	0	8
3	R:R:W155	R:R:Y104	35.8792	7.72	Yes	Yes	1	8	8
4	R:R:N108	R:R:W155	23.412	10.17	No	Yes	1	9	8
5	R:R:N108	R:R:S151	22.2576	4.47	No	No	0	9	9
6	R:R:A109	R:R:S151	20.9597	3.42	No	No	0	8	9
7	R:R:A109	R:R:W148	19.6493	7.78	No	No	0	8	9
8	R:R:A68	R:R:W148	18.3265	2.59	No	No	0	9	9
9	R:R:A68	R:R:C67	16.9911	1.81	No	No	0	9	7
10	R:R:C67	R:R:M45	15.6433	3.24	No	Yes	0	7	7
11	L:L:?1	R:R:W400	35.3613	8.82	Yes	Yes	1	0	9
12	R:R:T399	R:R:W400	15.9179	3.64	No	Yes	1	9	9
13	R:R:L428	R:R:T399	14.595	5.9	Yes	No	0	8	9
14	L:L:?1	R:R:S107	71.228	12.91	Yes	No	0	0	8
15	R:R:I72	R:R:S107	70.8162	4.64	Yes	No	0	8	8
16	R:R:I72	R:R:S433	100	4.64	Yes	No	0	8	9
17	R:R:D69	R:R:S433	99.2575	4.42	No	No	0	9	9
18	R:R:D69	R:R:N41	98.5024	16.16	No	No	0	9	9
19	R:R:N41	R:R:P437	97.7349	4.89	No	No	0	9	9
20	R:R:N436	R:R:P437	96.9549	6.52	No	No	0	9	9
21	R:R:L65	R:R:N436	96.1625	8.24	No	No	0	9	9
22	R:R:L65	R:R:N113	94.5401	5.49	No	No	0	9	9
23	R:R:N113	R:R:S64	93.7102	7.45	No	No	0	9	9
24	R:R:I144	R:R:S64	92.8678	3.1	No	No	0	9	9
25	R:R:F61	R:R:I144	91.1456	3.77	Yes	No	0	8	9
26	R:R:D120	R:R:F61	39.1239	10.75	No	Yes	3	9	8
27	R:R:D120	R:R:N58	43.8101	6.73	No	No	0	9	9
28	R:R:N58	R:R:T56	42.4373	4.39	No	No	0	9	8
29	R:R:N59	R:R:T56	41.0208	4.39	Yes	No	0	9	8
30	R:R:F447	R:R:N59	36.5531	9.67	Yes	Yes	2	9	9
31	R:R:F447	R:R:L54	29.3024	8.53	Yes	Yes	2	9	9
32	R:R:L54	R:R:T450	23.1436	5.9	Yes	No	2	9	8
33	R:R:S47	R:R:T450	21.6523	3.2	Yes	No	0	9	8
34	R:R:F451	R:R:S47	13.5655	2.64	No	Yes	0	9	9
35	R:R:F61	R:R:R135	44.5401	4.28	Yes	Yes	3	8	8
36	R:R:S76	R:R:Y430	33.5143	6.36	No	Yes	1	8	9
37	R:R:Y426	W:W:?1	64.2456	6.03	Yes	Yes	1	7	0
38	R:R:Y83	W:W:?1	33.1961	4.31	No	Yes	0	7	0
39	R:R:W89	R:R:Y83	26.2324	8.68	Yes	No	0	9	7
40	R:R:I178	R:R:Y104	24.8783	7.25	No	Yes	0	7	8
41	R:R:V111	R:R:W400	11.7746	4.9	No	Yes	0	9	9
42	R:R:R135	R:R:Y131	47.9408	18.52	Yes	Yes	0	8	9
43	R:R:F123	R:R:Y131	43.8038	16.5	No	Yes	0	6	9
44	R:R:F123	R:R:Y122	42.3998	5.16	No	Yes	0	6	9
45	R:R:L205	R:R:Y122	23.0126	5.86	No	Yes	0	8	9
46	R:R:L205	R:R:S118	19.8428	6.01	No	No	0	8	9
47	R:R:S118	R:R:Y206	18.2391	8.9	No	Yes	0	9	9
48	R:R:F180	R:R:I178	23.7614	7.54	Yes	No	0	7	7
49	R:R:F180	R:R:W162	11.5063	10.02	Yes	Yes	0	7	6
50	R:R:Y177	W:W:?1	11.5437	23.27	Yes	Yes	1	4	0
51	R:R:V171	R:R:Y177	10.4767	11.36	No	Yes	0	4	4
52	R:R:W422	W:W:?1	17.2345	78.71	Yes	Yes	1	6	0
53	R:R:Y426	R:R:Y430	27.4055	8.94	Yes	Yes	1	7	9
54	R:R:I72	R:R:S76	33.3833	4.64	Yes	No	0	8	8
55	R:R:Y104	R:R:Y426	15.3813	8.94	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	4.67	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y104	6.05	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S107	12.91	1	Yes	No	0	8	0	1
L:L:?1	R:R:W400	8.82	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y403	13.11	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y426	4.03	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C429	4.09	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y430	13.11	1	Yes	Yes	0	9	0	1
R:R:I72	R:R:S76	4.64	0	Yes	No	8	8	2	2
R:R:I72	R:R:S107	4.64	0	Yes	No	8	8	2	1
R:R:D103	R:R:S76	10.31	1	No	No	9	8	1	2
R:R:S76	R:R:Y430	6.36	1	No	Yes	8	9	2	1
R:R:M77	R:R:Y430	9.58	0	No	Yes	9	9	2	1
R:R:Y426	R:R:Y80	5.96	1	Yes	Yes	7	8	1	2
R:R:W427	R:R:Y80	6.75	1	No	Yes	9	8	2	2
R:R:Y80	W:W:?1	6.89	1	Yes	Yes	8	0	2	2
R:R:D103	R:R:Y430	9.2	1	No	Yes	9	9	1	1
R:R:W155	R:R:Y104	7.72	1	Yes	Yes	8	8	2	1
R:R:I159	R:R:Y104	3.63	1	No	Yes	8	8	2	1
R:R:I178	R:R:Y104	7.25	0	No	Yes	7	8	2	1
R:R:Y104	R:R:Y403	5.96	1	Yes	Yes	8	8	1	1
R:R:Y104	R:R:Y426	8.94	1	Yes	Yes	8	7	1	1
R:R:V111	R:R:W400	4.9	0	No	Yes	9	9	2	1
R:R:I159	R:R:W155	5.87	1	No	Yes	8	8	2	2
R:R:T399	R:R:W400	3.64	1	No	Yes	9	9	2	1
R:R:N432	R:R:T399	11.7	1	No	No	9	9	2	2
R:R:N404	R:R:W400	4.52	1	No	Yes	7	9	2	1
R:R:N432	R:R:W400	9.04	1	No	Yes	9	9	2	1
R:R:V407	R:R:Y403	5.05	0	No	Yes	8	8	2	1
R:R:Y403	R:R:Y426	6.95	1	Yes	Yes	8	7	1	1
R:R:C429	R:R:Y403	4.03	1	No	Yes	8	8	1	1
R:R:Y426	R:R:Y430	8.94	1	Yes	Yes	7	9	1	1
R:R:Y426	W:W:?1	6.03	1	Yes	Yes	7	0	1	2
R:R:W427	R:R:Y430	3.86	1	No	Yes	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y104	6.05	1	Yes	Yes	0	8	2	2
L:L:?1	R:R:Y403	13.11	1	Yes	Yes	0	8	2	2
L:L:?1	R:R:Y426	4.03	1	Yes	Yes	0	7	2	1
L:L:?1	R:R:Y430	13.11	1	Yes	Yes	0	9	2	2
R:R:T84	R:R:Y80	4.99	1	Yes	Yes	7	8	2	1
R:R:T423	R:R:Y80	6.24	1	No	Yes	6	8	1	1
R:R:Y426	R:R:Y80	5.96	1	Yes	Yes	7	8	1	1
R:R:W427	R:R:Y80	6.75	1	No	Yes	9	8	2	1
R:R:Y80	W:W:?1	6.89	1	Yes	Yes	8	0	1	0
R:R:W89	R:R:Y83	8.68	4	Yes	No	9	7	2	1
R:R:Y83	W:W:?1	4.31	0	No	Yes	7	0	1	0
R:R:T84	R:R:W427	3.64	1	Yes	No	7	9	2	2
R:R:Y104	R:R:Y403	5.96	1	Yes	Yes	8	8	2	2
R:R:Y104	R:R:Y426	8.94	1	Yes	Yes	8	7	2	1
R:R:F181	R:R:T170	3.89	1	Yes	No	5	5	1	2
R:R:V171	R:R:Y177	11.36	0	No	Yes	4	4	2	1
R:R:E172	R:R:E175	5.07	0	No	No	1	5	2	1
R:R:E175	R:R:Y177	12.35	1	No	Yes	5	4	1	1
R:R:E175	W:W:?1	5.85	1	No	Yes	5	0	1	0
R:R:F181	R:R:Y177	4.13	1	Yes	Yes	5	4	1	1
R:R:Y177	W:W:?1	23.27	1	Yes	Yes	4	0	1	0
R:R:F181	R:R:S182	10.57	1	Yes	No	5	6	1	2
R:R:F181	W:W:?1	10.75	1	Yes	Yes	5	0	1	0
R:R:Y403	R:R:Y426	6.95	1	Yes	Yes	8	7	2	1
R:R:N410	W:W:?1	8.08	0	No	Yes	4	0	1	0
R:R:I417	R:R:P418	5.08	1	No	No	7	7	2	2
R:R:I417	R:R:W422	3.52	1	No	Yes	7	6	2	1
R:R:P418	R:R:W422	10.81	1	No	Yes	7	6	2	1
R:R:W422	W:W:?1	78.71	1	Yes	Yes	6	0	1	0
R:R:T423	W:W:?1	10.84	1	No	Yes	6	0	1	0
R:R:Y426	R:R:Y430	8.94	1	Yes	Yes	7	9	1	2
R:R:Y426	W:W:?1	6.03	1	Yes	Yes	7	0	1	0
R:R:W427	R:R:Y430	3.86	1	No	Yes	9	9	2	2
R:R:M406	R:R:W422	2.33	0	No	Yes	7	6	2	1
R:R:G87	R:R:Y83	1.45	0	No	No	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T96_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	248
Number of Links	270
Number of Hubs	31
Number of Links mediated by Hubs	134
Number of Communities	6
Number of Nodes involved in Communities	50
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	31155
Length Of Smallest Path	3
Average Path Length	16.0142
Length of Longest Path	38
Minimum Path Strength	1.32
Average Path Strength	7.12597
Maximum Path Strength	50.99
Minimum Path Correlation	0.7
Average Path Correlation	0.935383
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	54.6873
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.7413
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • intracellular vesicle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • cytoplasm • organelle membrane • presynapse • somatodendritic compartment • dendrite • dendritic tree • neuron projection • cholinergic synapse • Golgi apparatus • endomembrane system • ciliary basal body • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACH
Name	Acetylcholine
Synonyms	Choline acetate O-Acetylcholine Acetylcholine Acetylcholine chloride ACh
Identifier
Formula	C7 H16 N O2
Molecular Weight	146.207
SMILES
PubChem	187
Formal Charge	1
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	25
Total Aromatic Bonds	0


Code	2CU
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	2CU
Name	3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
Synonyms	LY2119620 positive allosteric modulator of M2/M4 receptor
Identifier
Formula	C19 H24 Cl N5 O3 S
Molecular Weight	437.944
SMILES
PubChem	57664406
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08172
Sequence	>7T96_nogp_Chain_R E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N R H L Q T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G Y W P L G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P V K R T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G V R T V E D G E C Y I Q F F S N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T P C I P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K K T F K H L L M C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	3UON	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	3	2012-02-01	doi.org/10.1038/nature10753
	4MQS	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	-	-	3.5	2013-11-27	doi.org/10.1038/nature12735
	7T8X	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T8X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	5YC8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	2.5	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK3	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	2.6	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKB	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	AF-DX 384	-	-	2.95	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKC	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-Methyl-Scopolamine	-	-	2.3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8PM2	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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