psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L2	L:L:Q4	5.32	No	No	0	0	0
2	L:L:L2	R:R:H304	7.71	No	No	0	0	2
3	L:L:F3	L:L:P5	4.33	No	No	0	0	0
4	L:L:F3	R:R:E185	12.83	No	No	0	0	1
5	L:L:Q4	R:R:Q37	7.68	No	No	0	0	1
6	L:L:Q4	R:R:N104	5.28	No	No	0	0	4
7	L:L:F8	L:L:Q6	4.68	Yes	No	0	0	0
8	L:L:F8	L:L:R7	14.97	Yes	No	0	0	0
9	L:L:R7	R:R:Y216	7.2	No	Yes	0	0	6
10	L:L:R7	R:R:L290	10.93	No	No	0	0	5
11	L:L:?9	L:L:F8	6.03	No	Yes	0	0	0
12	L:L:F8	R:R:G120	4.52	Yes	No	5	0	5
13	L:L:F8	R:R:Q123	5.86	Yes	Yes	5	0	7
14	L:L:F8	R:R:G124	4.52	Yes	No	0	0	5
15	L:L:?9	R:R:H315	9.55	No	Yes	0	0	6
16	R:R:F189	R:R:L30	3.65	No	No	0	1	2
17	R:R:L30	R:R:V191	4.47	No	No	0	2	4
18	R:R:H187	R:R:T31	10.95	No	No	2	3	4
19	R:R:H188	R:R:T31	21.91	Yes	No	2	1	4
20	R:R:S34	R:R:Y35	13.99	No	No	0	5	4
21	R:R:D192	R:R:S34	10.31	No	No	0	5	5
22	R:R:I106	R:R:Y35	6.04	No	No	0	4	4
23	R:R:T39	R:R:Y36	8.74	No	No	0	3	4
24	R:R:H38	R:R:P41	7.63	No	No	0	4	1
25	R:R:H38	R:R:V42	8.3	No	No	0	4	4
26	R:R:P41	R:R:S40	5.34	No	No	0	1	2
27	R:R:F313	R:R:M45	8.71	No	No	0	5	4
28	R:R:F46	R:R:Y50	15.47	No	Yes	3	5	7
29	R:R:F46	R:R:L101	7.31	No	No	3	5	7
30	R:R:A49	R:R:W316	5.19	No	Yes	0	5	5
31	R:R:I53	R:R:Y50	7.25	No	Yes	3	7	7
32	R:R:L101	R:R:Y50	4.69	No	Yes	3	7	7
33	R:R:H315	R:R:Y50	3.27	Yes	Yes	0	6	7
34	R:R:W316	R:R:Y50	7.72	Yes	Yes	3	5	7
35	R:R:I53	R:R:M97	4.37	No	Yes	0	7	7
36	R:R:I53	R:R:W316	14.09	No	Yes	3	7	5
37	R:R:F54	R:R:M97	9.95	No	Yes	0	6	7
38	R:R:C57	R:R:D89	4.67	No	Yes	7	8	9
39	R:R:C57	R:R:S322	5.16	No	No	7	8	9
40	R:R:G60	R:R:V59	3.68	No	No	0	8	5
41	R:R:A86	R:R:N61	3.13	No	No	0	9	9
42	R:R:D89	R:R:N61	12.12	Yes	No	0	9	9
43	R:R:L90	R:R:N61	8.24	No	No	0	7	9
44	R:R:F336	R:R:I67	13.82	Yes	No	0	8	7
45	R:R:N79	R:R:V68	7.39	No	No	4	8	6
46	R:R:L83	R:R:V68	5.96	No	No	0	6	6
47	R:R:F336	R:R:V68	3.93	Yes	No	4	8	6
48	R:R:M74	R:R:N71	15.43	No	No	0	7	5
49	R:R:N71	R:R:N79	13.62	No	No	4	5	8
50	R:R:F336	R:R:N71	3.62	Yes	No	4	8	5
51	R:R:H73	R:R:R72	6.77	No	No	0	5	6
52	R:R:H75	R:R:R72	4.51	No	No	0	7	6
53	R:R:H73	R:R:M74	3.94	No	No	0	5	7
54	R:R:T76	R:R:V77	4.76	No	Yes	8	7	7
55	R:R:T76	R:R:T78	4.71	No	No	0	7	8
56	R:R:T154	R:R:T76	4.71	Yes	No	8	7	7
57	R:R:F81	R:R:V77	5.24	No	Yes	0	8	7
58	R:R:E140	R:R:V77	8.56	No	Yes	0	8	7
59	R:R:T154	R:R:V77	11.11	Yes	Yes	8	7	7
60	R:R:F336	R:R:N79	4.83	Yes	No	4	8	8
61	R:R:F81	R:R:I162	10.05	No	No	0	8	8
62	R:R:F336	R:R:I82	5.02	Yes	No	0	8	8
63	R:R:N84	R:R:T133	8.77	Yes	No	0	9	8
64	R:R:I162	R:R:N84	5.66	No	Yes	0	8	9
65	R:R:I165	R:R:N84	4.25	No	Yes	0	7	9
66	R:R:N84	R:R:W166	4.52	Yes	Yes	0	9	9
67	R:R:S130	R:R:S88	4.89	No	No	0	9	8
68	R:R:D89	R:R:S322	4.42	Yes	No	7	9	9
69	R:R:D89	R:R:P326	4.83	Yes	No	0	9	9
70	R:R:L91	R:R:S126	6.01	No	No	0	7	8
71	R:R:L91	R:R:W166	3.42	No	Yes	0	7	9
72	R:R:S126	R:R:V92	6.46	No	No	0	8	7
73	R:R:G93	R:R:M97	3.49	No	Yes	0	7	7
74	R:R:F95	R:R:V122	7.87	No	No	0	6	5
75	R:R:C96	R:R:Q123	6.1	No	Yes	0	7	7
76	R:R:M97	R:R:P98	3.35	Yes	No	0	7	8
77	R:R:F319	R:R:M97	7.46	No	Yes	0	7	7
78	R:R:T99	R:R:W109	10.92	No	Yes	0	6	8
79	R:R:Q123	R:R:T99	8.5	Yes	No	0	7	6
80	R:R:P110	R:R:V102	5.3	No	No	0	3	4
81	R:R:D103	R:R:G108	3.35	No	No	0	4	4
82	R:R:D103	R:R:W109	26.8	No	Yes	0	4	8
83	R:R:N104	R:R:P312	4.89	No	No	0	4	3
84	R:R:I106	R:R:T107	3.04	No	No	0	4	4
85	R:R:H188	R:R:T107	4.11	Yes	No	2	1	4
86	R:R:L200	R:R:T107	7.37	No	No	2	1	4
87	R:R:P110	R:R:W109	4.05	No	Yes	0	3	8
88	R:R:D112	R:R:W109	7.82	Yes	Yes	1	8	8
89	R:R:T115	R:R:W109	6.06	No	Yes	0	6	8
90	R:R:C116	R:R:W109	5.22	Yes	Yes	1	9	8
91	R:R:S119	R:R:W109	3.71	No	Yes	0	5	8
92	R:R:C203	R:R:W109	3.92	No	Yes	1	9	8
93	R:R:F111	R:R:P110	14.45	No	No	0	7	3
94	R:R:F111	R:R:R196	6.41	No	Yes	0	7	6
95	R:R:C116	R:R:D112	6.22	Yes	Yes	1	9	8
96	R:R:D112	R:R:V182	8.76	Yes	No	1	8	5
97	R:R:D112	R:R:Y201	9.2	Yes	Yes	1	8	3
98	R:R:N113	R:R:Y201	15.12	No	Yes	0	3	3
99	R:R:C116	R:R:V182	3.42	Yes	No	1	9	5
100	R:R:C116	R:R:C203	5.46	Yes	No	1	9	9
101	R:R:K117	R:R:L121	4.23	No	No	0	7	6
102	R:R:G120	R:R:Q123	4.93	No	Yes	5	5	7
103	R:R:M125	R:R:W166	3.49	No	Yes	0	6	9
104	R:R:L170	R:R:M125	9.9	No	No	0	4	6
105	R:R:M125	R:R:M173	4.33	No	No	0	6	7
106	R:R:V127	R:R:W283	4.9	No	Yes	0	7	8
107	R:R:F132	R:R:S128	3.96	No	No	0	6	6
108	R:R:I224	R:R:S128	3.1	No	No	0	6	6
109	R:R:A129	R:R:W166	9.08	No	Yes	0	7	9
110	R:R:I224	R:R:V131	3.07	No	No	0	6	8
111	R:R:L134	R:R:N325	6.87	No	No	0	8	9
112	R:R:L134	R:R:Y329	3.52	No	Yes	0	8	9
113	R:R:P228	R:R:V135	3.53	No	No	0	9	7
114	R:R:I232	R:R:V135	6.14	No	No	0	8	7
115	R:R:I137	R:R:Y329	6.04	No	Yes	0	9	9
116	R:R:A138	R:R:Y236	4	No	Yes	0	9	9
117	R:R:M235	R:R:V139	6.09	No	No	0	7	6
118	R:R:C144	R:R:E140	7.6	No	No	0	8	8
119	R:R:R141	R:R:Y329	8.23	No	Yes	0	9	9
120	R:R:F142	R:R:V146	10.49	Yes	No	0	8	6
121	R:R:F142	R:R:M235	11.2	Yes	No	0	8	7
122	R:R:F142	R:R:R238	3.21	Yes	No	0	8	4
123	R:R:F142	R:R:I239	5.02	Yes	No	0	8	8
124	R:R:H147	R:R:V146	5.54	No	No	0	6	6
125	R:R:H147	R:R:R150	14.67	No	No	0	6	4
126	R:R:F149	R:R:P148	10.11	No	No	0	6	8
127	R:R:L153	R:R:L155	4.15	No	No	0	6	4
128	R:R:A158	R:R:T154	3.36	No	Yes	0	7	7
129	R:R:L159	R:R:R156	12.15	No	No	0	3	5
130	R:R:I172	R:R:L220	4.28	No	No	0	5	5
131	R:R:H223	R:R:I172	3.98	No	No	0	5	5
132	R:R:M173	R:R:S176	3.07	No	No	0	7	6
133	R:R:L220	R:R:M173	4.24	No	No	0	5	7
134	R:R:C174	R:R:P175	3.77	No	No	0	4	7
135	R:R:A206	R:R:S176	3.42	No	No	6	3	6
136	R:R:S176	R:R:Y216	7.63	No	Yes	6	6	6
137	R:R:C203	R:R:L180	3.17	No	No	0	9	5
138	R:R:T181	R:R:T183	3.14	No	No	0	5	3
139	R:R:V182	R:R:Y201	6.31	No	Yes	1	5	3
140	R:R:T183	R:R:W204	9.7	No	No	0	3	3
141	R:R:E186	R:R:R184	11.63	No	No	0	1	1
142	R:R:E185	R:R:H188	4.92	No	Yes	0	1	1
143	R:R:H187	R:R:H188	4.78	No	Yes	2	3	1
144	R:R:H188	R:R:L200	3.86	Yes	No	2	1	1
145	R:R:M190	R:R:R196	4.96	No	Yes	0	2	6
146	R:R:L200	R:R:M190	7.07	No	No	0	1	2
147	R:R:S197	R:R:V191	3.23	No	No	0	3	4
148	R:R:R196	R:R:Y198	5.14	Yes	No	0	6	2
149	R:R:P199	R:R:Y198	6.95	No	No	0	4	2
150	R:R:P199	R:R:Y201	4.17	No	Yes	0	4	3
151	R:R:E205	R:R:W204	10.9	No	No	0	4	3
152	R:R:P208	R:R:W204	5.4	No	No	0	3	3
153	R:R:E205	R:R:R213	10.47	No	No	0	4	4
154	R:R:A206	R:R:Y216	6.67	No	Yes	6	3	6
155	R:R:P208	R:R:W207	6.76	No	No	0	3	5
156	R:R:M212	R:R:W207	12.8	No	No	0	3	5
157	R:R:E209	R:R:M212	4.06	No	No	0	2	3
158	R:R:M212	R:R:V215	3.04	No	No	0	3	4
159	R:R:D294	R:R:R214	8.34	No	No	0	5	3
160	R:R:R214	R:R:Y295	18.52	No	No	0	3	4
161	R:R:T217	R:R:Y216	4.99	No	Yes	0	5	6
162	R:R:L220	R:R:W287	4.56	No	Yes	0	5	7
163	R:R:F221	R:R:W287	4.01	No	Yes	0	6	7
164	R:R:L226	R:R:S222	9.01	No	No	0	5	5
165	R:R:I224	R:R:W287	9.4	No	Yes	0	6	7
166	R:R:L229	R:R:Y225	10.55	No	No	0	6	8
167	R:R:W283	R:R:Y225	3.86	Yes	No	0	8	8
168	R:R:L284	R:R:Y225	7.03	No	No	0	5	8
169	R:R:F279	R:R:L229	7.31	No	No	0	9	6
170	R:R:L229	R:R:T280	4.42	No	No	0	6	5
171	R:R:I232	R:R:Y236	3.63	No	Yes	0	8	9
172	R:R:M235	R:R:Y236	3.59	No	Yes	0	7	9
173	R:R:L272	R:R:Y236	14.07	No	Yes	0	8	9
174	R:R:V275	R:R:Y236	3.79	No	Yes	0	8	9
175	R:R:K242	R:R:R238	6.19	No	No	0	4	4
176	R:R:A240	R:R:V269	5.09	No	No	0	5	7
177	R:R:K242	R:R:R241	3.71	No	No	0	4	4
178	R:R:C244	R:R:R265	13.93	No	No	0	5	6
179	R:R:H270	R:R:R267	11.28	No	No	0	6	7
180	R:R:M271	R:R:R267	4.96	No	No	0	8	7
181	R:R:F332	R:R:M271	6.22	No	No	0	6	8
182	R:R:I328	R:R:V275	4.61	No	No	0	8	8
183	R:R:F278	R:R:N321	9.67	No	Yes	0	5	9
184	R:R:A324	R:R:F278	4.16	No	No	0	6	5
185	R:R:F279	R:R:W283	5.01	No	Yes	0	9	8
186	R:R:S282	R:R:W283	4.94	No	Yes	9	8	8
187	R:R:N321	R:R:S282	7.45	Yes	No	9	9	8
188	R:R:A318	R:R:W283	3.89	No	Yes	0	7	8
189	R:R:N321	R:R:W283	10.17	Yes	Yes	9	9	8
190	R:R:L317	R:R:P285	6.57	No	No	0	7	9
191	R:R:L286	R:R:W287	3.42	No	Yes	0	7	7
192	R:R:H315	R:R:L286	5.14	Yes	No	0	6	7
193	R:R:A318	R:R:L286	3.15	No	No	0	7	7
194	R:R:L290	R:R:W287	5.69	No	Yes	0	5	7
195	R:R:F311	R:R:L289	7.31	No	No	0	4	5
196	R:R:L291	R:R:Y295	3.52	No	No	0	6	4
197	R:R:L303	R:R:Q297	7.99	No	No	0	3	2
198	R:R:L298	R:R:Q302	5.32	No	No	0	2	2
199	R:R:A300	R:R:P301	3.74	No	No	0	1	4
200	R:R:H304	R:R:T307	5.48	No	No	0	2	4
201	R:R:H304	R:R:V308	15.22	No	No	0	2	3
202	R:R:F313	R:R:Y309	24.76	No	No	0	5	1
203	R:R:F311	R:R:H315	4.53	No	Yes	0	4	6
204	R:R:F320	R:R:W316	8.02	No	Yes	0	5	5
205	R:R:F320	R:R:S323	5.28	No	No	0	5	7
206	R:R:N321	R:R:N325	4.09	Yes	No	0	9	9
207	R:R:I328	R:R:Y329	6.04	No	Yes	0	8	9
208	R:R:G330	R:R:N333	3.39	No	No	0	6	8
209	R:R:F332	R:R:Y331	10.32	No	No	0	6	5
210	R:R:R337	R:R:Y331	5.14	No	No	0	8	5
211	R:R:N333	R:R:N335	12.26	No	No	0	8	6
212	R:R:F336	R:R:N333	7.25	Yes	No	0	8	8
213	R:R:E334	R:R:R337	4.65	No	No	0	4	8
214	R:R:A300	R:R:Q302	3.03	No	No	0	1	2
215	R:R:M74	R:R:T78	3.01	No	No	0	7	8
216	R:R:L56	R:R:S323	3	No	No	0	5	7
217	R:R:K152	R:R:T154	3	No	Yes	0	5	7
218	R:R:L52	R:R:V48	2.98	No	No	0	5	6
219	R:R:L243	R:R:V268	2.98	No	No	0	8	8
220	R:R:L243	R:R:V269	2.98	No	No	0	8	7
221	R:R:L85	R:R:T133	2.95	No	No	0	9	8
222	R:R:I162	R:R:M80	2.92	No	No	0	8	5
223	R:R:F189	R:R:P199	2.89	No	No	0	1	4
224	R:R:W207	R:R:Y216	2.89	No	Yes	0	5	6
225	R:R:D294	R:R:T217	2.89	No	No	0	5	5
226	R:R:Q297	R:R:S299	2.89	No	No	0	2	3
227	R:R:I67	R:R:L63	2.85	No	No	0	7	6
228	R:R:I239	R:R:L243	2.85	No	No	0	8	8
229	R:R:K157	R:R:L153	2.82	No	No	0	5	6
230	R:R:H223	R:R:S222	2.79	No	No	0	5	5
231	R:R:P312	R:R:Y50	2.78	No	Yes	0	3	7
232	R:R:L55	R:R:L56	2.77	No	No	0	5	5
233	R:R:A136	R:R:F81	2.77	No	No	0	7	8
234	R:R:H223	R:R:V219	2.77	No	No	0	5	3
235	R:R:E209	R:R:K210	2.7	No	No	0	2	1
236	R:R:L305	R:R:Q302	2.66	No	No	0	2	2
237	R:R:F54	R:R:M58	2.49	No	No	0	6	6
238	R:R:M80	R:R:R156	2.48	No	No	0	5	5
239	R:R:F46	R:R:L105	2.44	No	No	0	5	5
240	R:R:N335	R:R:R338	2.41	No	No	0	6	4
241	R:R:L317	R:R:W316	2.28	No	Yes	0	7	5
242	R:R:R194	R:R:R196	2.13	No	Yes	0	4	6
243	R:R:G60	R:R:P326	2.03	No	No	0	8	9
244	R:R:A227	R:R:P228	1.87	No	No	0	5	9
245	R:R:A314	R:R:P285	1.87	No	No	0	6	9
246	R:R:G108	R:R:S202	1.86	No	No	0	4	4
247	R:R:G330	R:R:V64	1.84	No	No	0	6	9
248	R:R:A266	R:R:C244	1.81	No	No	0	5	5
249	R:R:P326	R:R:V64	1.77	No	No	0	9	9
250	R:R:G339	R:R:K70	1.74	No	No	0	6	5
251	R:R:G211	R:R:K210	1.74	No	No	0	3	1
252	R:R:A129	R:R:S88	1.71	No	No	0	7	8
253	R:R:A169	R:R:S128	1.71	No	No	0	8	6
254	R:R:A167	R:R:V164	1.7	No	No	0	4	3
255	R:R:A310	R:R:V306	1.7	No	No	0	5	3
256	R:R:M45	R:R:P312	1.68	No	No	0	4	3
257	R:R:C144	R:R:I145	1.64	No	No	0	8	8
258	R:R:A324	R:R:I327	1.62	No	No	0	6	7
259	R:R:S33	R:R:T31	1.6	No	No	0	5	4
260	R:R:V308	R:R:V42	1.6	No	No	0	3	4
261	R:R:V233	R:R:V234	1.6	No	No	0	4	3
262	R:R:V269	R:R:V273	1.6	No	No	0	7	5
263	R:R:T307	R:R:V306	1.59	No	No	0	4	3
264	R:R:A177	R:R:L121	1.58	No	No	0	5	6
265	R:R:A193	R:R:D192	1.54	No	No	0	6	5
266	R:R:H147	R:R:P148	1.53	No	No	0	6	8
267	R:R:K117	R:R:V178	1.52	No	No	0	7	4
268	R:R:M97	R:R:T100	1.51	Yes	No	0	7	6
269	R:R:G339	R:R:R338	1.5	No	No	0	6	4
270	R:R:L91	R:R:V122	1.49	No	No	0	7	5
271	R:R:L121	R:R:V122	1.49	No	No	0	6	5
272	R:R:L277	R:R:V273	1.49	No	No	0	5	5
273	R:R:L298	R:R:V306	1.49	No	No	0	2	3
274	R:R:L305	R:R:V308	1.49	No	No	0	2	3
275	R:R:I165	R:R:L168	1.43	No	No	0	7	4
276	R:R:L298	R:R:L303	1.38	No	No	0	2	3
277	R:R:I293	R:R:Q297	1.37	No	No	0	4	2
278	R:R:R143	R:R:V139	1.31	No	No	0	5	6
279	R:R:R184	R:R:T183	1.29	No	No	0	1	3
280	R:R:F95	R:R:I94	1.26	No	No	0	6	5
281	R:R:T218	R:R:Y295	1.25	No	No	0	4	4
282	R:R:F66	R:R:L69	1.22	No	No	0	4	3
283	R:R:L155	R:R:R156	1.21	No	No	0	4	5
284	R:R:D192	R:R:F32	1.19	No	No	0	5	5
285	R:R:R264	R:R:R267	1.07	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F8	6.76333	6	5	0
2	R:R:Y50	6.86333	6	3	7
3	R:R:V77	7.4175	4	8	7
4	R:R:N84	5.8	4	0	9
5	R:R:D89	6.51	4	7	9
6	R:R:M97	5.02167	6	0	7
7	R:R:W109	8.5625	8	1	8
8	R:R:D112	8	4	1	8
9	R:R:C116	5.08	4	1	9
10	R:R:Q123	6.3475	4	5	7
11	R:R:F142	7.48	4	0	8
12	R:R:T154	5.545	4	8	7
13	R:R:W166	5.1275	4	0	9
14	R:R:H188	7.916	5	2	1
15	R:R:R196	4.66	4	0	6
16	R:R:Y201	8.7	4	1	3
17	R:R:Y216	5.876	5	6	6
18	R:R:Y236	5.816	5	0	9
19	R:R:W283	5.46167	6	9	8
20	R:R:W287	5.416	5	0	7
21	R:R:H315	5.6225	4	0	6
22	R:R:W316	7.46	5	3	5
23	R:R:N321	7.845	4	9	9
24	R:R:Y329	5.9575	4	0	9
25	R:R:F336	6.41167	6	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H188	R:R:L200	13.0512	3.86	Yes	No	2	1	1
2	R:R:L200	R:R:M190	27.7135	7.07	No	No	0	1	2
3	R:R:M190	R:R:R196	29.448	4.96	No	Yes	0	2	6
4	R:R:F111	R:R:R196	33.3565	6.41	No	Yes	0	7	6
5	R:R:F111	R:R:P110	34.9445	14.45	No	No	0	7	3
6	R:R:P110	R:R:W109	38.1514	4.05	No	Yes	0	3	8
7	R:R:T99	R:R:W109	69.1258	10.92	No	Yes	0	6	8
8	R:R:Q123	R:R:T99	70.4826	8.5	Yes	No	0	7	6
9	L:L:F8	R:R:Q123	72.7413	5.86	Yes	Yes	5	0	7
10	L:L:?9	L:L:F8	47.3404	6.03	No	Yes	0	0	0
11	L:L:?9	R:R:H315	47.6334	9.55	No	Yes	0	0	6
12	R:R:H315	R:R:Y50	75.8326	3.27	Yes	Yes	0	6	7
13	R:R:P312	R:R:Y50	46.0376	2.78	No	Yes	0	3	7
14	R:R:N104	R:R:P312	39.5467	4.89	No	No	0	4	3
15	L:L:Q4	R:R:N104	38.0281	5.28	No	No	0	0	4
16	L:L:L2	L:L:Q4	34.8289	5.32	No	No	0	0	0
17	L:L:F8	L:L:R7	50.4163	14.97	Yes	No	0	0	0
18	L:L:R7	R:R:Y216	54.6408	7.2	No	Yes	0	0	6
19	R:R:H315	R:R:L286	70.6907	5.14	Yes	No	0	6	7
20	R:R:L286	R:R:W287	74.1443	3.42	No	Yes	0	7	7
21	R:R:L290	R:R:W287	16.1887	5.69	No	Yes	0	5	7
22	R:R:D112	R:R:W109	17.4761	7.82	Yes	Yes	1	8	8
23	R:R:D112	R:R:Y201	14.2538	9.2	Yes	Yes	1	8	3
24	R:R:P199	R:R:Y201	11.4169	4.17	No	Yes	0	4	3
25	R:R:L200	R:R:T107	12.9047	7.37	No	No	2	1	4
26	R:R:I106	R:R:T107	11.5557	3.04	No	No	0	4	4
27	L:L:L2	R:R:H304	33.1175	7.71	No	No	0	0	2
28	R:R:H304	R:R:V308	16.8363	15.22	No	No	0	2	3
29	R:R:W316	R:R:Y50	16.7129	7.72	Yes	Yes	3	5	7
30	R:R:I53	R:R:Y50	14.8551	7.25	No	Yes	3	7	7
31	R:R:I53	R:R:M97	13.5368	4.37	No	Yes	0	7	7
32	R:R:L220	R:R:W287	66.4971	4.56	No	Yes	0	5	7
33	R:R:L220	R:R:M173	63.4906	4.24	No	No	0	5	7
34	R:R:M125	R:R:M173	100	4.33	No	No	0	6	7
35	R:R:M125	R:R:W166	98.119	3.49	No	Yes	0	6	9
36	R:R:N84	R:R:W166	83.2254	4.52	Yes	Yes	0	9	9
37	R:R:I162	R:R:N84	77.1739	5.66	No	Yes	0	8	9
38	R:R:F81	R:R:I162	68.1545	10.05	No	No	0	8	8
39	R:R:F81	R:R:V77	65.4641	5.24	No	Yes	0	8	7
40	R:R:T76	R:R:V77	55.0031	4.76	No	Yes	8	7	7
41	R:R:T76	R:R:T78	54.2399	4.71	No	No	0	7	8
42	R:R:M74	R:R:T78	52.7212	3.01	No	No	0	7	8
43	R:R:M74	R:R:N71	46.4924	15.43	No	No	0	7	5
44	R:R:F336	R:R:N71	39.5082	3.62	Yes	No	4	8	5
45	R:R:F336	R:R:N333	29.5945	7.25	Yes	No	0	8	8
46	R:R:G330	R:R:N333	20.7678	3.39	No	No	0	6	8
47	R:R:G330	R:R:V64	18.9562	1.84	No	No	0	6	9
48	R:R:P326	R:R:V64	17.1292	1.77	No	No	0	9	9
49	R:R:D89	R:R:P326	11.5557	4.83	Yes	No	0	9	9
50	R:R:L91	R:R:W166	19.1104	3.42	No	Yes	0	7	9
51	R:R:L91	R:R:V122	13.5368	1.49	No	No	0	7	5
52	R:R:A318	R:R:L286	77.1045	3.15	No	No	0	7	7
53	R:R:A318	R:R:W283	75.848	3.89	No	Yes	0	7	8
54	R:R:N321	R:R:W283	62.1492	10.17	Yes	Yes	9	9	8
55	R:R:N321	R:R:N325	56.6374	4.09	Yes	No	0	9	9
56	R:R:L134	R:R:N325	55.1264	6.87	No	No	0	8	9
57	R:R:L134	R:R:Y329	53.5846	3.52	No	Yes	0	8	9
58	R:R:I328	R:R:Y329	49.2831	6.04	No	Yes	0	8	9
59	R:R:I328	R:R:V275	47.7027	4.61	No	No	0	8	8
60	R:R:V275	R:R:Y236	46.2303	3.79	No	Yes	0	8	9
61	R:R:M235	R:R:Y236	34.8674	3.59	No	Yes	0	7	9
62	R:R:F142	R:R:M235	29.7101	11.2	Yes	No	0	8	7
63	R:R:F142	R:R:I239	13.4058	5.02	Yes	No	0	8	8
64	R:R:I162	R:R:M80	11.5094	2.92	No	No	0	8	5
65	R:R:S176	R:R:Y216	40.572	7.63	No	Yes	6	6	6
66	R:R:M173	R:R:S176	42.0444	3.07	No	No	0	7	6
67	R:R:W207	R:R:Y216	26.0638	2.89	No	Yes	0	5	6
68	R:R:P208	R:R:W207	15.1943	6.76	No	No	0	3	5
69	R:R:P208	R:R:W204	13.3287	5.4	No	No	0	3	3
70	R:R:T217	R:R:Y216	11.4863	4.99	No	Yes	0	5	6
71	R:R:I239	R:R:L243	11.5171	2.85	No	No	0	8	8
72	R:R:H304	R:R:T307	14.8011	5.48	No	No	0	2	4
73	R:R:T307	R:R:V306	12.9741	1.59	No	No	0	4	3
74	L:L:R7	R:R:L290	15.3253	10.93	No	No	0	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:L2	R:R:H304	7.71	0	No	No	0	2	0	1
L:L:F3	R:R:E185	12.83	0	No	No	0	1	0	1
L:L:Q4	R:R:Q37	7.68	0	No	No	0	1	0	1
L:L:Q4	R:R:N104	5.28	0	No	No	0	4	0	1
L:L:R7	R:R:Y216	7.2	0	No	Yes	0	6	0	1
L:L:R7	R:R:L290	10.93	0	No	No	0	5	0	1
L:L:F8	R:R:G120	4.52	5	Yes	No	0	5	0	1
L:L:F8	R:R:Q123	5.86	5	Yes	Yes	0	7	0	1
L:L:F8	R:R:G124	4.52	5	Yes	No	0	5	0	1
L:L:?9	R:R:H315	9.55	0	No	Yes	0	6	0	1
R:R:H315	R:R:Y50	3.27	0	Yes	Yes	6	7	1	2
R:R:C96	R:R:Q123	6.1	0	No	Yes	7	7	2	1
R:R:Q123	R:R:T99	8.5	5	Yes	No	7	6	1	2
R:R:N104	R:R:P312	4.89	0	No	No	4	3	1	2
R:R:G120	R:R:Q123	4.93	5	No	Yes	5	7	1	1
R:R:A206	R:R:S176	3.42	6	No	No	3	6	2	2
R:R:S176	R:R:Y216	7.63	6	No	Yes	6	6	2	1
R:R:E185	R:R:H188	4.92	0	No	Yes	1	1	1	2
R:R:A206	R:R:Y216	6.67	6	No	Yes	3	6	2	1
R:R:T217	R:R:Y216	4.99	0	No	Yes	5	6	2	1
R:R:L286	R:R:W287	3.42	0	No	Yes	7	7	2	2
R:R:H315	R:R:L286	5.14	0	Yes	No	6	7	1	2
R:R:L290	R:R:W287	5.69	0	No	Yes	5	7	1	2
R:R:H304	R:R:T307	5.48	0	No	No	2	4	1	2
R:R:H304	R:R:V308	15.22	0	No	No	2	3	1	2
R:R:F311	R:R:H315	4.53	0	No	Yes	4	6	2	1
R:R:W207	R:R:Y216	2.89	0	No	Yes	5	6	2	1
R:R:P312	R:R:Y50	2.78	0	No	Yes	3	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M2F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	274
Number of Links	285
Number of Hubs	25
Number of Links mediated by Hubs	109
Number of Communities	9
Number of Nodes involved in Communities	35
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	32539
Length Of Smallest Path	3
Average Path Length	15.5655
Length of Longest Path	38
Minimum Path Strength	1.365
Average Path Strength	5.89809
Maximum Path Strength	18.86
Minimum Path Correlation	0.7
Average Path Correlation	0.924353
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.0962
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.5636
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ6
Sequence	>9M2F_nogp_Chain_R L T F S S Y Y Q H T S P V A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N R H M H T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T G W P F D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H P F R E K L T L R K A L V T I A V I W A L A L L I M C P S A V T L T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G Q L S A P Q L H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F R R G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M0R	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide VF	-	Gi1/β1/γ2	2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M0R (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide VF	-		2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9M2F_nogp.zip

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