psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	R:R:W204	14.86	No	No	0	0	3
2	L:L:N3	R:R:S202	8.94	No	No	0	0	4
3	L:L:P5	R:R:N104	3.26	Yes	No	0	0	4
4	L:L:P5	R:R:T307	5.25	Yes	No	0	0	4
5	L:L:P5	R:R:F311	13	Yes	No	0	0	4
6	L:L:Q6	R:R:D103	3.92	No	No	0	0	4
7	L:L:Q6	R:R:Q123	6.4	No	Yes	0	0	7
8	L:L:F8	L:L:R7	11.76	Yes	Yes	0	0	0
9	L:L:R7	R:R:E205	4.65	Yes	Yes	2	0	4
10	L:L:R7	R:R:T217	3.88	Yes	No	2	0	5
11	L:L:R7	R:R:L290	6.07	Yes	No	2	0	5
12	L:L:F8	R:R:V127	9.18	Yes	No	0	0	7
13	L:L:F8	R:R:W287	7.02	Yes	Yes	0	0	7
14	L:L:?9	R:R:T100	3.65	Yes	No	1	0	6
15	L:L:?9	R:R:Q123	9.88	Yes	Yes	1	0	7
16	L:L:?9	R:R:H315	6.36	Yes	Yes	1	0	6
17	L:L:?9	R:R:F319	6.03	Yes	Yes	1	0	7
18	R:R:F32	R:R:L30	3.65	No	No	0	5	2
19	R:R:H188	R:R:T31	13.69	No	No	0	1	4
20	R:R:F189	R:R:F32	4.29	No	No	0	1	5
21	R:R:H188	R:R:S33	6.97	No	No	0	1	5
22	R:R:T107	R:R:Y35	14.98	Yes	No	4	4	4
23	R:R:W109	R:R:Y35	12.54	Yes	No	4	8	4
24	R:R:I106	R:R:Y36	15.71	No	No	0	4	4
25	R:R:G108	R:R:Q37	3.29	No	No	0	4	1
26	R:R:H38	R:R:V42	4.15	No	No	0	4	4
27	R:R:F46	R:R:H38	10.18	No	No	0	5	4
28	R:R:P41	R:R:T39	5.25	No	No	0	1	3
29	R:R:T39	R:R:V42	4.76	No	No	0	3	4
30	R:R:P41	R:R:S40	3.56	No	No	0	1	2
31	R:R:A49	R:R:W316	3.89	No	Yes	0	5	5
32	R:R:M97	R:R:Y50	4.79	Yes	No	0	7	7
33	R:R:L101	R:R:Y50	23.45	No	No	0	7	7
34	R:R:I53	R:R:M97	4.37	No	Yes	0	7	7
35	R:R:I53	R:R:W316	8.22	No	Yes	0	7	5
36	R:R:F54	R:R:M58	3.73	No	No	0	6	6
37	R:R:F54	R:R:M97	7.46	No	Yes	1	6	7
38	R:R:F54	R:R:P98	10.11	No	No	1	6	8
39	R:R:L56	R:R:S323	4.5	No	No	0	5	7
40	R:R:C57	R:R:M58	4.86	No	No	0	8	6
41	R:R:C57	R:R:N61	3.15	No	Yes	0	8	9
42	R:R:G60	R:R:V59	3.68	No	No	0	8	5
43	R:R:G60	R:R:P326	4.06	No	No	0	8	9
44	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
45	R:R:D89	R:R:N61	12.12	Yes	Yes	0	9	9
46	R:R:L90	R:R:N61	6.87	No	Yes	0	7	9
47	R:R:N61	R:R:P326	4.89	Yes	No	0	9	9
48	R:R:F66	R:R:K70	7.44	No	No	0	4	5
49	R:R:I67	R:R:K70	5.82	No	No	0	7	5
50	R:R:F336	R:R:I67	8.79	Yes	No	0	8	7
51	R:R:L83	R:R:V68	8.94	No	No	0	6	6
52	R:R:K70	R:R:N71	15.39	No	No	0	5	5
53	R:R:M74	R:R:N71	7.01	Yes	No	0	7	5
54	R:R:H73	R:R:M74	7.88	No	Yes	0	5	7
55	R:R:M74	R:R:N79	5.61	Yes	No	0	7	8
56	R:R:T76	R:R:T78	3.14	No	No	0	7	8
57	R:R:N79	R:R:T76	8.77	No	No	0	8	7
58	R:R:L153	R:R:V77	4.47	Yes	No	0	6	7
59	R:R:E140	R:R:T78	12.7	Yes	No	0	8	8
60	R:R:A136	R:R:F81	4.16	No	Yes	0	7	8
61	R:R:F81	R:R:I137	6.28	Yes	Yes	0	8	9
62	R:R:E140	R:R:F81	7	Yes	Yes	0	8	8
63	R:R:F81	R:R:T161	6.49	Yes	No	0	8	6
64	R:R:F336	R:R:I82	7.54	Yes	No	0	8	8
65	R:R:N84	R:R:T133	8.77	No	No	0	9	8
66	R:R:I162	R:R:N84	12.74	No	No	6	8	9
67	R:R:N84	R:R:W166	5.65	No	Yes	6	9	9
68	R:R:D89	R:R:L85	4.07	Yes	Yes	3	9	9
69	R:R:L85	R:R:T133	5.9	Yes	No	0	9	8
70	R:R:L85	R:R:N325	10.98	Yes	No	3	9	9
71	R:R:A129	R:R:S88	3.42	No	No	0	7	8
72	R:R:S130	R:R:S88	4.89	No	No	0	9	8
73	R:R:D89	R:R:S130	4.42	Yes	No	0	9	9
74	R:R:D89	R:R:S322	8.83	Yes	No	0	9	9
75	R:R:D89	R:R:N325	12.12	Yes	No	3	9	9
76	R:R:F95	R:R:L91	3.65	No	Yes	0	6	7
77	R:R:L91	R:R:S126	6.01	Yes	No	0	7	8
78	R:R:L91	R:R:W166	3.42	Yes	Yes	0	7	9
79	R:R:G93	R:R:V92	3.68	No	Yes	0	7	7
80	R:R:C96	R:R:V92	6.83	No	Yes	0	7	7
81	R:R:S126	R:R:V92	6.46	No	Yes	0	8	7
82	R:R:S322	R:R:V92	8.08	No	Yes	0	9	7
83	R:R:G93	R:R:M97	3.49	No	Yes	0	7	7
84	R:R:F95	R:R:I94	5.02	No	No	0	6	5
85	R:R:F95	R:R:V122	14.42	No	No	0	6	5
86	R:R:C96	R:R:F319	6.98	No	Yes	0	7	7
87	R:R:M97	R:R:P98	3.35	Yes	No	1	7	8
88	R:R:F319	R:R:M97	8.71	Yes	Yes	1	7	7
89	R:R:S119	R:R:T99	6.4	No	No	1	5	6
90	R:R:Q123	R:R:T99	4.25	Yes	No	1	7	6
91	R:R:H315	R:R:T100	8.21	Yes	No	1	6	6
92	R:R:F319	R:R:T100	7.78	Yes	No	1	7	6
93	R:R:L101	R:R:L105	8.3	No	Yes	0	7	5
94	R:R:D103	R:R:P110	6.44	No	No	0	4	3
95	R:R:I106	R:R:L105	8.56	No	Yes	0	4	5
96	R:R:G108	R:R:T107	3.64	No	Yes	0	4	4
97	R:R:T107	R:R:W109	9.7	Yes	Yes	4	4	8
98	R:R:M190	R:R:W109	8.14	No	Yes	4	2	8
99	R:R:W109	R:R:Y198	23.15	Yes	Yes	4	8	2
100	R:R:C116	R:R:P110	5.65	No	No	7	9	3
101	R:R:C203	R:R:P110	9.41	No	No	7	9	3
102	R:R:F111	R:R:T115	15.56	No	No	0	7	6
103	R:R:D112	R:R:N113	4.04	No	No	0	8	3
104	R:R:D112	R:R:T115	5.78	No	No	0	8	6
105	R:R:M118	R:R:T115	4.52	No	No	0	4	6
106	R:R:C116	R:R:L180	3.17	No	No	0	9	5
107	R:R:C116	R:R:C203	7.28	No	No	7	9	9
108	R:R:K117	R:R:L180	5.64	No	No	0	7	5
109	R:R:M118	R:R:S119	3.07	No	No	0	4	5
110	R:R:Q123	R:R:S119	5.78	Yes	No	1	7	5
111	R:R:G120	R:R:Q123	6.58	No	Yes	0	5	7
112	R:R:L121	R:R:M173	4.24	No	No	0	6	7
113	R:R:M125	R:R:W166	3.49	No	Yes	0	6	9
114	R:R:L170	R:R:M125	4.24	No	No	0	4	6
115	R:R:F132	R:R:S128	3.96	No	Yes	0	6	6
116	R:R:I224	R:R:S128	3.1	No	Yes	0	6	6
117	R:R:A129	R:R:W166	5.19	No	Yes	0	7	9
118	R:R:I224	R:R:V131	3.07	No	Yes	0	6	8
119	R:R:P228	R:R:V131	3.53	No	Yes	0	9	8
120	R:R:F279	R:R:V131	5.24	No	Yes	0	9	8
121	R:R:V131	R:R:W283	3.68	Yes	Yes	0	8	8
122	R:R:F132	R:R:I165	8.79	No	No	0	6	7
123	R:R:L134	R:R:Y329	3.52	No	Yes	0	8	9
124	R:R:P228	R:R:V135	3.53	No	No	0	9	7
125	R:R:I232	R:R:V135	6.14	No	No	0	8	7
126	R:R:I137	R:R:R141	3.76	Yes	No	3	9	9
127	R:R:I137	R:R:Y329	7.25	Yes	Yes	3	9	9
128	R:R:A138	R:R:Y236	4	No	Yes	0	9	9
129	R:R:M235	R:R:V139	6.09	No	No	0	7	6
130	R:R:E140	R:R:L153	9.28	Yes	Yes	0	8	6
131	R:R:R141	R:R:Y236	6.17	No	Yes	0	9	9
132	R:R:R141	R:R:Y329	3.09	No	Yes	3	9	9
133	R:R:F142	R:R:R143	4.28	Yes	No	0	8	5
134	R:R:F142	R:R:V146	10.49	Yes	No	0	8	6
135	R:R:F142	R:R:M235	13.68	Yes	No	0	8	7
136	R:R:F142	R:R:R238	3.21	Yes	No	0	8	4
137	R:R:F142	R:R:I239	6.28	Yes	No	0	8	8
138	R:R:E151	R:R:R143	12.79	No	No	0	6	5
139	R:R:I145	R:R:V146	4.61	No	No	0	8	6
140	R:R:I145	R:R:I239	10.3	No	No	0	8	8
141	R:R:I145	R:R:K242	5.82	No	No	0	8	4
142	R:R:H147	R:R:V146	9.69	No	No	0	6	6
143	R:R:H147	R:R:R150	10.16	No	No	0	6	4
144	R:R:F149	R:R:P148	5.78	No	No	8	6	8
145	R:R:P148	R:R:R150	4.32	No	No	8	8	4
146	R:R:F149	R:R:R150	17.1	No	No	8	6	4
147	R:R:R156	R:R:T154	3.88	No	No	0	5	7
148	R:R:K157	R:R:R156	6.19	No	No	0	5	5
149	R:R:R156	R:R:V160	6.54	No	No	0	5	2
150	R:R:I162	R:R:W166	5.87	No	Yes	6	8	9
151	R:R:C174	R:R:L170	3.17	No	No	0	4	4
152	R:R:H223	R:R:I172	11.93	No	No	0	5	5
153	R:R:P175	R:R:Y216	13.91	No	Yes	0	7	6
154	R:R:S176	R:R:Y216	6.36	No	Yes	0	6	6
155	R:R:E205	R:R:T179	8.47	Yes	No	2	4	5
156	R:R:T179	R:R:W207	19.41	No	Yes	2	5	5
157	R:R:E205	R:R:L180	3.98	Yes	No	0	4	5
158	R:R:A206	R:R:T181	5.03	No	No	0	3	5
159	R:R:V182	R:R:Y201	6.31	No	No	0	5	3
160	R:R:C203	R:R:V182	5.12	No	No	0	9	5
161	R:R:E185	R:R:T183	7.06	No	No	5	1	3
162	R:R:S202	R:R:T183	3.2	No	No	5	4	3
163	R:R:E186	R:R:R184	3.49	No	No	0	1	1
164	R:R:E185	R:R:S202	8.62	No	No	5	1	4
165	R:R:H188	R:R:L200	16.71	No	No	0	1	1
166	R:R:F189	R:R:V191	5.24	No	No	0	1	4
167	R:R:F189	R:R:S197	3.96	No	No	0	1	3
168	R:R:M190	R:R:Y198	3.59	No	Yes	4	2	2
169	R:R:L200	R:R:M190	5.65	No	No	0	1	2
170	R:R:N195	R:R:V191	5.91	No	No	0	6	4
171	R:R:D192	R:R:R194	9.53	No	No	0	5	4
172	R:R:R194	R:R:R196	3.2	No	No	0	4	6
173	R:R:P199	R:R:Y198	5.56	No	Yes	0	4	2
174	R:R:Y198	R:R:Y201	9.93	Yes	No	0	2	3
175	R:R:A206	R:R:W204	3.89	No	No	0	3	3
176	R:R:E205	R:R:W207	5.45	Yes	Yes	2	4	5
177	R:R:E205	R:R:R213	4.65	Yes	Yes	2	4	4
178	R:R:P208	R:R:W207	5.4	No	Yes	2	3	5
179	R:R:M212	R:R:W207	10.47	No	Yes	2	3	5
180	R:R:R213	R:R:W207	5	Yes	Yes	2	4	5
181	R:R:W207	R:R:Y216	10.61	Yes	Yes	0	5	6
182	R:R:M212	R:R:P208	5.03	No	No	2	3	3
183	R:R:E209	R:R:G211	4.91	No	No	0	2	3
184	R:R:E209	R:R:M212	9.47	No	No	0	2	3
185	R:R:G211	R:R:K210	3.49	No	No	9	3	1
186	R:R:K210	R:R:R214	3.71	No	Yes	9	1	3
187	R:R:G211	R:R:R214	4.5	No	Yes	9	3	3
188	R:R:D294	R:R:R213	13.1	No	Yes	0	5	4
189	R:R:D294	R:R:R214	4.76	No	Yes	0	5	3
190	R:R:R214	R:R:Y295	9.26	Yes	No	0	3	4
191	R:R:L220	R:R:Y216	7.03	No	Yes	0	5	6
192	R:R:L290	R:R:T217	4.42	No	No	2	5	5
193	R:R:D294	R:R:T217	15.9	No	No	0	5	5
194	R:R:T218	R:R:Y295	4.99	No	No	0	4	4
195	R:R:F221	R:R:Y225	9.28	Yes	Yes	0	6	8
196	R:R:F221	R:R:L226	8.53	Yes	No	0	6	5
197	R:R:F221	R:R:W287	10.02	Yes	Yes	0	6	7
198	R:R:F221	R:R:L291	8.53	Yes	No	0	6	6
199	R:R:L226	R:R:S222	6.01	No	No	0	5	5
200	R:R:I224	R:R:W287	10.57	No	Yes	0	6	7
201	R:R:L229	R:R:Y225	7.03	No	Yes	0	6	8
202	R:R:W283	R:R:Y225	5.79	Yes	Yes	0	8	8
203	R:R:L284	R:R:Y225	10.55	No	Yes	0	5	8
204	R:R:F279	R:R:L229	6.09	No	No	0	9	6
205	R:R:L229	R:R:T280	5.9	No	No	0	6	5
206	R:R:L272	R:R:Y236	16.41	No	Yes	0	8	9
207	R:R:V275	R:R:Y236	3.79	No	Yes	0	8	9
208	R:R:A240	R:R:V269	5.09	No	No	0	5	7
209	R:R:K242	R:R:L243	8.46	No	No	0	4	8
210	R:R:F332	R:R:M271	6.22	No	No	0	6	8
211	R:R:L277	R:R:T280	4.42	No	No	0	5	5
212	R:R:F278	R:R:S282	3.96	Yes	No	10	5	8
213	R:R:F278	R:R:F320	5.36	Yes	No	0	5	5
214	R:R:F278	R:R:N321	7.25	Yes	No	10	5	9
215	R:R:L281	R:R:T280	5.9	No	No	0	6	5
216	R:R:N321	R:R:S282	7.45	No	No	10	9	8
217	R:R:W283	R:R:W287	6.56	Yes	Yes	0	8	7
218	R:R:N321	R:R:W283	9.04	No	Yes	0	9	8
219	R:R:L284	R:R:P285	3.28	No	No	0	5	9
220	R:R:L317	R:R:P285	4.93	No	No	0	7	9
221	R:R:A314	R:R:L286	4.73	No	No	0	6	7
222	R:R:H315	R:R:L286	12.86	Yes	No	0	6	7
223	R:R:A318	R:R:L286	3.15	No	No	0	7	7
224	R:R:L290	R:R:W287	3.42	No	Yes	0	5	7
225	R:R:L289	R:R:V306	5.96	No	Yes	11	5	3
226	R:R:A310	R:R:L289	3.15	No	No	11	5	5
227	R:R:L292	R:R:L298	12.46	No	No	0	4	2
228	R:R:I293	R:R:V306	4.61	No	Yes	0	4	3
229	R:R:L298	R:R:Q302	10.65	No	No	0	2	2
230	R:R:P301	R:R:S299	5.34	No	No	0	4	3
231	R:R:H304	R:R:L305	3.86	No	No	0	2	2
232	R:R:H304	R:R:V308	9.69	No	No	0	2	3
233	R:R:L305	R:R:Y309	3.52	No	No	0	2	1
234	R:R:A310	R:R:V306	3.39	No	Yes	11	5	3
235	R:R:V308	R:R:Y309	12.62	No	No	0	3	1
236	R:R:F311	R:R:H315	9.05	No	Yes	0	4	6
237	R:R:F313	R:R:W316	4.01	No	Yes	0	5	5
238	R:R:F319	R:R:H315	9.05	Yes	Yes	1	7	6
239	R:R:L317	R:R:W316	3.42	No	Yes	0	7	5
240	R:R:F320	R:R:S323	5.28	No	No	0	5	7
241	R:R:I328	R:R:Y329	4.84	No	Yes	0	8	9
242	R:R:R337	R:R:Y331	6.17	No	No	0	8	5
243	R:R:N333	R:R:N335	10.9	No	No	0	8	6
244	R:R:F336	R:R:N333	3.62	Yes	No	0	8	8
245	R:R:E334	R:R:R337	6.98	No	No	0	4	8
246	R:R:N335	R:R:R338	8.44	No	No	0	6	4
247	R:R:C144	R:R:E140	3.04	No	Yes	0	8	8
248	L:L:F8	R:R:G124	3.01	Yes	No	0	0	5
249	R:R:K152	R:R:T154	3	No	No	0	5	7
250	R:R:R213	R:R:W204	3	Yes	No	0	4	3
251	R:R:L91	R:R:V87	2.98	Yes	No	0	7	6
252	R:R:L272	R:R:V268	2.98	No	No	0	8	8
253	R:R:A266	R:R:H270	2.93	No	No	0	5	6
254	R:R:I328	R:R:M274	2.92	No	No	0	8	6
255	R:R:F46	R:R:P312	2.89	No	No	0	5	3
256	R:R:I137	R:R:L85	2.85	Yes	Yes	3	9	9
257	R:R:I293	R:R:L292	2.85	No	No	0	4	4
258	R:R:L155	R:R:M80	2.83	No	No	0	4	5
259	R:R:K157	R:R:L153	2.82	No	Yes	0	5	6
260	R:R:C244	R:R:R241	2.79	No	No	0	5	4
261	R:R:L55	R:R:L56	2.77	No	No	0	5	5
262	R:R:H223	R:R:V219	2.77	No	No	0	5	3
263	R:R:H270	R:R:V269	2.77	No	No	0	6	7
264	R:R:A324	R:R:F278	2.77	No	Yes	0	6	5
265	R:R:L303	R:R:Q297	2.66	No	No	0	3	2
266	R:R:F311	R:R:V306	2.62	No	Yes	0	4	3
267	R:R:H38	R:R:L105	2.57	No	Yes	0	4	5
268	R:R:F132	R:R:L168	2.44	No	No	0	6	4
269	R:R:L153	R:R:R143	2.43	Yes	No	0	6	5
270	R:R:Q245	R:R:R241	2.34	No	No	0	4	4
271	R:R:E334	R:R:R338	2.33	No	No	0	4	4
272	R:R:H75	R:R:R72	2.26	No	No	0	7	6
273	R:R:F332	R:R:R267	2.14	No	No	0	6	7
274	R:R:R184	R:R:Y201	2.06	No	No	0	1	3
275	R:R:A227	R:R:P228	1.87	No	No	0	5	9
276	R:R:A300	R:R:P301	1.87	No	No	0	1	4
277	R:R:A86	R:R:C65	1.81	No	No	0	9	7
278	L:L:P2	L:L:V1	1.77	No	No	0	0	0
279	R:R:P326	R:R:V64	1.77	No	No	0	9	9
280	R:R:G339	R:R:M74	1.75	No	Yes	0	6	7
281	R:R:G124	R:R:M173	1.75	No	No	0	5	7
282	R:R:A169	R:R:S128	1.71	No	Yes	0	8	6
283	R:R:A158	R:R:V77	1.7	No	No	0	7	7
284	L:L:L4	L:L:P5	1.64	No	Yes	0	0	0
285	R:R:G296	R:R:Q297	1.64	No	No	0	3	2
286	R:R:A324	R:R:I327	1.62	No	No	0	6	7
287	R:R:A158	R:R:M80	1.61	No	No	0	7	5
288	R:R:V160	R:R:V164	1.6	No	No	0	2	3
289	R:R:V233	R:R:V234	1.6	No	No	0	4	3
290	R:R:V269	R:R:V273	1.6	No	No	0	7	5
291	R:R:C65	R:R:L83	1.59	No	No	0	7	6
292	R:R:T107	R:R:V102	1.59	Yes	No	0	4	4
293	R:R:T179	R:R:V178	1.59	No	No	0	5	4
294	R:R:T307	R:R:V308	1.59	No	No	0	4	3
295	R:R:A43	R:R:L105	1.58	No	Yes	0	4	5
296	R:R:A288	R:R:L289	1.58	No	No	0	5	5
297	R:R:A114	R:R:N113	1.56	No	No	0	1	3
298	R:R:I172	R:R:S128	1.55	No	Yes	0	5	6
299	R:R:F336	R:R:G330	1.51	Yes	No	0	8	6
300	R:R:L52	R:R:V48	1.49	No	No	0	5	6
301	R:R:L231	R:R:V135	1.49	No	No	0	6	7
302	R:R:L303	R:R:T307	1.47	No	No	0	3	4
303	R:R:M271	R:R:M274	1.44	No	No	0	8	6
304	R:R:I47	R:R:L105	1.43	No	Yes	0	5	5
305	R:R:L159	R:R:M80	1.41	No	No	0	3	5
306	R:R:L52	R:R:L55	1.38	No	No	0	5	5
307	R:R:H75	R:R:V68	1.38	No	No	0	7	6
308	R:R:E185	R:R:L200	1.33	No	No	0	1	1
309	R:R:E186	R:R:H187	1.23	No	No	0	1	3
310	R:R:F66	R:R:L63	1.22	No	No	0	4	6
311	R:R:R264	R:R:R267	1.07	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P5	5.7875	4	0	0
2	L:L:R7	6.59	4	2	0
3	L:L:F8	7.7425	4	0	0
4	L:L:?9	6.48	4	1	0
5	R:R:N61	6.344	5	0	9
6	R:R:M74	5.5625	4	0	7
7	R:R:F81	5.9825	4	0	8
8	R:R:L85	5.95	4	3	9
9	R:R:D89	8.312	5	3	9
10	R:R:L91	4.015	4	0	7
11	R:R:V92	6.2625	4	0	7
12	R:R:M97	5.36167	6	1	7
13	R:R:L105	4.488	5	0	5
14	R:R:T107	7.4775	4	4	4
15	R:R:W109	13.3825	4	4	8
16	R:R:Q123	6.578	5	1	7
17	R:R:S128	2.58	4	0	6
18	R:R:V131	3.88	4	0	8
19	R:R:I137	5.035	4	3	9
20	R:R:E140	8.005	4	0	8
21	R:R:F142	7.588	5	0	8
22	R:R:L153	4.75	4	0	6
23	R:R:W166	4.724	5	6	9
24	R:R:Y198	10.5575	4	4	2
25	R:R:E205	5.44	5	2	4
26	R:R:W207	9.39	6	2	5
27	R:R:R213	6.4375	4	2	4
28	R:R:R214	5.5575	4	9	3
29	R:R:Y216	9.4775	4	0	6
30	R:R:F221	9.09	4	0	6
31	R:R:Y225	8.1625	4	0	8
32	R:R:Y236	7.5925	4	0	9
33	R:R:F278	4.835	4	10	5
34	R:R:W283	6.2675	4	0	8
35	R:R:W287	7.518	5	0	7
36	R:R:V306	4.145	4	11	3
37	R:R:H315	9.106	5	1	6
38	R:R:W316	4.885	4	0	5
39	R:R:F319	7.71	5	1	7
40	R:R:Y329	4.675	4	3	9
41	R:R:F336	5.365	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L200	R:R:M190	17.0799	5.65	No	No	0	1	2
2	R:R:M190	R:R:Y198	18.8232	3.59	No	Yes	4	2	2
3	R:R:Y198	R:R:Y201	35.1227	9.93	Yes	No	0	2	3
4	R:R:V182	R:R:Y201	42.9452	6.31	No	No	0	5	3
5	R:R:C203	R:R:V182	44.8647	5.12	No	No	0	9	5
6	R:R:C116	R:R:C203	20.6608	7.28	No	No	7	9	9
7	R:R:C116	R:R:L180	60.9566	3.17	No	No	0	9	5
8	R:R:E205	R:R:L180	60.3398	3.98	Yes	No	0	4	5
9	R:R:E205	R:R:R213	20.6734	4.65	Yes	Yes	2	4	4
10	R:R:R213	R:R:W204	13.3669	3	Yes	No	0	4	3
11	R:R:C116	R:R:P110	40.6608	5.65	No	No	7	9	3
12	R:R:D103	R:R:P110	66.8722	6.44	No	No	0	4	3
13	L:L:Q6	R:R:D103	66.9163	3.92	No	No	0	0	4
14	L:L:Q6	R:R:Q123	67.1114	6.4	No	Yes	0	0	7
15	L:L:?9	R:R:Q123	71.0132	9.88	Yes	Yes	1	0	7
16	L:L:?9	R:R:H315	11.3153	6.36	Yes	Yes	1	0	6
17	R:R:F311	R:R:H315	36.6583	9.05	No	Yes	0	4	6
18	L:L:P5	R:R:F311	21.5922	13	Yes	No	0	0	4
19	L:L:P5	R:R:T307	16.4191	5.25	Yes	No	0	0	4
20	L:L:F8	L:L:R7	22.9893	11.76	Yes	Yes	0	0	0
21	L:L:R7	R:R:E205	44.078	4.65	Yes	Yes	2	0	4
22	R:R:D294	R:R:R213	10.7741	13.1	No	Yes	0	5	4
23	L:L:R7	R:R:L290	20.6042	6.07	Yes	No	2	0	5
24	L:L:F8	R:R:W287	29.9434	7.02	Yes	Yes	0	0	7
25	R:R:L290	R:R:W287	31.6425	3.42	No	Yes	0	5	7
26	L:L:?9	R:R:F319	60.0944	6.03	Yes	Yes	1	0	7
27	R:R:W109	R:R:Y198	12.3726	23.15	Yes	Yes	4	8	2
28	R:R:F319	R:R:M97	33.7445	8.71	Yes	Yes	1	7	7
29	R:R:M97	R:R:Y50	26.073	4.79	Yes	No	0	7	7
30	R:R:L101	R:R:Y50	24.292	23.45	No	No	0	7	7
31	R:R:L101	R:R:L105	22.4984	8.3	No	Yes	0	7	5
32	R:R:H38	R:R:L105	13.3417	2.57	No	Yes	0	4	5
33	R:R:F221	R:R:W287	28.2819	10.02	Yes	Yes	0	6	7
34	R:R:F221	R:R:Y225	28.9113	9.28	Yes	Yes	0	6	8
35	R:R:L284	R:R:Y225	79.5784	10.55	No	Yes	0	5	8
36	R:R:L284	R:R:P285	78.8798	3.28	No	No	0	5	9
37	R:R:L317	R:R:P285	78.2001	4.93	No	No	0	7	9
38	R:R:L317	R:R:W316	78.2631	3.42	No	Yes	0	7	5
39	R:R:W283	R:R:W287	41.202	6.56	Yes	Yes	0	8	7
40	R:R:W283	R:R:Y225	53.1278	5.79	Yes	Yes	0	8	8
41	R:R:I53	R:R:W316	78.4896	8.22	No	Yes	0	7	5
42	R:R:I53	R:R:M97	78.6973	4.37	No	Yes	0	7	7
43	R:R:F54	R:R:M97	19.1693	7.46	No	Yes	1	6	7
44	R:R:F54	R:R:M58	18.9427	3.73	No	No	0	6	6
45	R:R:N321	R:R:W283	23.7382	9.04	No	Yes	0	9	8
46	R:R:F278	R:R:N321	19.4777	7.25	Yes	No	10	5	9
47	R:R:F278	R:R:F320	13.1278	5.36	Yes	No	0	5	5
48	R:R:F320	R:R:S323	10.9755	5.28	No	No	0	5	7
49	R:R:C57	R:R:M58	18.219	4.86	No	No	0	8	6
50	R:R:C96	R:R:F319	61.0761	6.98	No	Yes	0	7	7
51	R:R:C96	R:R:V92	60.516	6.83	No	Yes	0	7	7
52	R:R:S322	R:R:V92	100	8.08	No	Yes	0	9	7
53	R:R:D89	R:R:S322	99.314	8.83	Yes	No	0	9	9
54	R:R:D89	R:R:N61	16.394	12.12	Yes	Yes	0	9	9
55	R:R:C57	R:R:N61	17.6023	3.15	No	Yes	0	8	9
56	R:R:N61	R:R:P326	10.1133	4.89	Yes	No	0	9	9
57	R:R:A86	R:R:N61	15.0975	4.69	No	Yes	0	9	9
58	R:R:D89	R:R:L85	96.287	4.07	Yes	Yes	3	9	9
59	R:R:I137	R:R:L85	99.5846	2.85	Yes	Yes	3	9	9
60	R:R:F81	R:R:I137	83.4172	6.28	Yes	Yes	0	8	9
61	R:R:E140	R:R:F81	79.9182	7	Yes	Yes	0	8	8
62	R:R:E140	R:R:T78	34.8332	12.7	Yes	No	0	8	8
63	R:R:T76	R:R:T78	33.2347	3.14	No	No	0	7	8
64	R:R:N79	R:R:T76	31.5985	8.77	No	No	0	8	7
65	R:R:M74	R:R:N79	29.9497	5.61	Yes	No	0	7	8
66	R:R:M74	R:R:N71	24.9276	7.01	Yes	No	0	7	5
67	R:R:K70	R:R:N71	23.2284	15.39	No	No	0	5	5
68	R:R:I67	R:R:K70	18.0554	5.82	No	No	0	7	5
69	R:R:F336	R:R:I67	16.3059	8.79	Yes	No	0	8	7
70	R:R:A86	R:R:C65	12.6117	1.81	No	No	0	9	7
71	R:R:C65	R:R:L83	10.1133	1.59	No	No	0	7	6
72	R:R:E140	R:R:L153	50.214	9.28	Yes	Yes	0	8	6
73	R:R:S126	R:R:V92	16.7716	6.46	No	Yes	0	8	7
74	R:R:L91	R:R:S126	15.0975	6.01	Yes	No	0	7	8
75	R:R:L91	R:R:W166	11.1013	3.42	Yes	Yes	0	7	9
76	R:R:G93	R:R:M97	55.28	3.49	No	Yes	0	7	7
77	R:R:Q123	R:R:S119	14.8836	5.78	Yes	No	1	7	5
78	R:R:M118	R:R:S119	12.832	3.07	No	No	0	4	5
79	R:R:M118	R:R:T115	10.7237	4.52	No	No	0	4	6
80	R:R:I224	R:R:W287	32.7565	10.57	No	Yes	0	6	7
81	R:R:I224	R:R:S128	33.0711	3.1	No	Yes	0	6	6
82	R:R:F132	R:R:S128	12.4921	3.96	No	Yes	0	6	6
83	R:R:I224	R:R:V131	16.331	3.07	No	Yes	0	6	8
84	R:R:V131	R:R:W283	22.8068	3.68	Yes	Yes	0	8	8
85	R:R:P228	R:R:V131	15.0661	3.53	No	Yes	0	9	8
86	R:R:I137	R:R:Y329	14.0906	7.25	Yes	Yes	3	9	9
87	R:R:I137	R:R:R141	10.4972	3.76	Yes	No	3	9	9
88	R:R:L153	R:R:R143	31.3908	2.43	Yes	No	0	6	5
89	R:R:F142	R:R:R143	28.0868	4.28	Yes	No	0	8	5
90	R:R:F142	R:R:V146	14.2668	10.49	Yes	No	0	8	6
91	R:R:K157	R:R:L153	10.9817	2.82	No	Yes	0	5	6
92	R:R:I172	R:R:S128	12.4921	1.55	No	Yes	0	5	6
93	R:R:D294	R:R:R214	11.5796	4.76	No	Yes	0	5	3
94	R:R:L229	R:R:Y225	11.5859	7.03	No	Yes	0	6	8
95	R:R:I328	R:R:Y329	10.8811	4.84	No	Yes	0	8	9
96	R:R:F311	R:R:V306	14.6444	2.62	No	Yes	0	4	3
97	R:R:F336	R:R:N333	10.9817	3.62	Yes	No	0	8	8
98	R:R:C203	R:R:P110	26.1045	9.41	No	No	7	9	3
99	R:R:E205	R:R:W207	18.4393	5.45	Yes	Yes	2	4	5
100	R:R:F319	R:R:H315	31.5481	9.05	Yes	Yes	1	7	6
101	R:R:G93	R:R:V92	54.6444	3.68	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P2	R:R:W204	14.86	0	No	No	0	3	0	1
L:L:N3	R:R:S202	8.94	0	No	No	0	4	0	1
L:L:P5	R:R:N104	3.26	0	Yes	No	0	4	0	1
L:L:P5	R:R:T307	5.25	0	Yes	No	0	4	0	1
L:L:P5	R:R:F311	13	0	Yes	No	0	4	0	1
L:L:Q6	R:R:D103	3.92	0	No	No	0	4	0	1
L:L:Q6	R:R:Q123	6.4	0	No	Yes	0	7	0	1
L:L:R7	R:R:E205	4.65	2	Yes	Yes	0	4	0	1
L:L:R7	R:R:T217	3.88	2	Yes	No	0	5	0	1
L:L:R7	R:R:L290	6.07	2	Yes	No	0	5	0	1
L:L:F8	R:R:V127	9.18	0	Yes	No	0	7	0	1
L:L:F8	R:R:W287	7.02	0	Yes	Yes	0	7	0	1
L:L:?9	R:R:T100	3.65	1	Yes	No	0	6	0	1
L:L:?9	R:R:Q123	9.88	1	Yes	Yes	0	7	0	1
L:L:?9	R:R:H315	6.36	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F319	6.03	1	Yes	Yes	0	7	0	1
R:R:C96	R:R:F319	6.98	0	No	Yes	7	7	2	1
R:R:F319	R:R:M97	8.71	1	Yes	Yes	7	7	1	2
R:R:S119	R:R:T99	6.4	1	No	No	5	6	2	2
R:R:Q123	R:R:T99	4.25	1	Yes	No	7	6	1	2
R:R:H315	R:R:T100	8.21	1	Yes	No	6	6	1	1
R:R:F319	R:R:T100	7.78	1	Yes	No	7	6	1	1
R:R:D103	R:R:P110	6.44	0	No	No	4	3	1	2
R:R:Q123	R:R:S119	5.78	1	Yes	No	7	5	1	2
R:R:G120	R:R:Q123	6.58	0	No	Yes	5	7	2	1
R:R:E205	R:R:T179	8.47	2	Yes	No	4	5	1	2
R:R:T179	R:R:W207	19.41	2	No	Yes	5	5	2	2
R:R:E205	R:R:L180	3.98	2	Yes	No	4	5	1	2
R:R:E185	R:R:T183	7.06	5	No	No	1	3	2	2
R:R:S202	R:R:T183	3.2	5	No	No	4	3	1	2
R:R:E185	R:R:S202	8.62	5	No	No	1	4	2	1
R:R:A206	R:R:W204	3.89	0	No	No	3	3	2	1
R:R:E205	R:R:W207	5.45	2	Yes	Yes	4	5	1	2
R:R:E205	R:R:R213	4.65	2	Yes	Yes	4	4	1	2
R:R:R213	R:R:W207	5	2	Yes	Yes	4	5	2	2
R:R:D294	R:R:R213	13.1	0	No	Yes	5	4	2	2
R:R:L290	R:R:T217	4.42	2	No	No	5	5	1	1
R:R:D294	R:R:T217	15.9	0	No	No	5	5	2	1
R:R:F221	R:R:W287	10.02	0	Yes	Yes	6	7	2	1
R:R:I224	R:R:W287	10.57	0	No	Yes	6	7	2	1
R:R:W283	R:R:W287	6.56	0	Yes	Yes	8	7	2	1
R:R:H315	R:R:L286	12.86	1	Yes	No	6	7	1	2
R:R:L290	R:R:W287	3.42	2	No	Yes	5	7	1	1
R:R:F311	R:R:H315	9.05	0	No	Yes	4	6	1	1
R:R:F319	R:R:H315	9.05	1	Yes	Yes	7	6	1	1
L:L:F8	R:R:G124	3.01	0	Yes	No	0	5	0	1
R:R:R213	R:R:W204	3	2	Yes	No	4	3	2	1
R:R:F311	R:R:V306	2.62	0	No	Yes	4	3	1	2
R:R:G124	R:R:M173	1.75	0	No	No	5	7	1	2
R:R:T307	R:R:V308	1.59	0	No	No	4	3	1	2
R:R:L303	R:R:T307	1.47	0	No	No	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M0R_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	285
Number of Links	311
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	11
Number of Nodes involved in Communities	51
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	46258
Length Of Smallest Path	3
Average Path Length	15.1542
Length of Longest Path	38
Minimum Path Strength	1.435
Average Path Strength	6.33251
Maximum Path Strength	16.425
Minimum Path Correlation	0.7
Average Path Correlation	0.926471
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.4406
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.0723
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • neuropeptide signaling pathway
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ6
Sequence	>9M0R_nogp_Chain_R L T F S S Y Y Q H T S P V A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N R H M H T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T G W P F D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H P F R E K L T L R K A L V T I A V I W A L A L L I M C P S A V T L T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G Q L S A P Q L H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F R R G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M0R	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide VF	-	Gi1/β1/γ2	2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M0R (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide VF	-		2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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Download 9M0R_nogp.zip

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