psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	R:R:W204	14.86	No	No	0	0	3
2	L:L:N3	R:R:S202	8.94	No	No	0	0	4
3	L:L:P5	R:R:N104	3.26	Yes	No	0	0	4
4	L:L:P5	R:R:T307	5.25	Yes	No	0	0	4
5	L:L:P5	R:R:F311	13	Yes	No	0	0	4
6	L:L:Q6	R:R:D103	3.92	No	No	0	0	4
7	L:L:Q6	R:R:Q123	6.4	No	Yes	0	0	7
8	L:L:F8	L:L:R7	11.76	Yes	Yes	0	0	0
9	L:L:R7	R:R:E205	4.65	Yes	Yes	2	0	4
10	L:L:R7	R:R:T217	3.88	Yes	No	2	0	5
11	L:L:R7	R:R:L290	6.07	Yes	No	2	0	5
12	L:L:F8	R:R:V127	9.18	Yes	No	0	0	7
13	L:L:F8	R:R:W287	7.02	Yes	Yes	0	0	7
14	L:L:?9	R:R:T100	3.65	Yes	No	1	0	6
15	L:L:?9	R:R:Q123	9.88	Yes	Yes	1	0	7
16	L:L:?9	R:R:H315	6.36	Yes	Yes	1	0	6
17	L:L:?9	R:R:F319	6.03	Yes	Yes	1	0	7
18	R:R:F32	R:R:L30	3.65	No	No	0	5	2
19	R:R:H188	R:R:T31	13.69	No	No	0	1	4
20	R:R:F189	R:R:F32	4.29	No	No	0	1	5
21	R:R:H188	R:R:S33	6.97	No	No	0	1	5
22	R:R:T107	R:R:Y35	14.98	Yes	No	4	4	4
23	R:R:W109	R:R:Y35	12.54	Yes	No	4	8	4
24	R:R:I106	R:R:Y36	15.71	No	No	0	4	4
25	R:R:G108	R:R:Q37	3.29	No	No	0	4	1
26	R:R:H38	R:R:V42	4.15	No	No	0	4	4
27	R:R:F46	R:R:H38	10.18	No	No	0	5	4
28	R:R:P41	R:R:T39	5.25	No	No	0	1	3
29	R:R:T39	R:R:V42	4.76	No	No	0	3	4
30	R:R:P41	R:R:S40	3.56	No	No	0	1	2
31	R:R:A49	R:R:W316	3.89	No	Yes	0	5	5
32	R:R:M97	R:R:Y50	4.79	Yes	No	0	7	7
33	R:R:L101	R:R:Y50	23.45	No	No	0	7	7
34	R:R:I53	R:R:M97	4.37	No	Yes	0	7	7
35	R:R:I53	R:R:W316	8.22	No	Yes	0	7	5
36	R:R:F54	R:R:M58	3.73	No	No	0	6	6
37	R:R:F54	R:R:M97	7.46	No	Yes	1	6	7
38	R:R:F54	R:R:P98	10.11	No	No	1	6	8
39	R:R:L56	R:R:S323	4.5	No	No	0	5	7
40	R:R:C57	R:R:M58	4.86	No	No	0	8	6
41	R:R:C57	R:R:N61	3.15	No	Yes	0	8	9
42	R:R:G60	R:R:V59	3.68	No	No	0	8	5
43	R:R:G60	R:R:P326	4.06	No	No	0	8	9
44	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
45	R:R:D89	R:R:N61	12.12	Yes	Yes	0	9	9
46	R:R:L90	R:R:N61	6.87	No	Yes	0	7	9
47	R:R:N61	R:R:P326	4.89	Yes	No	0	9	9
48	R:R:F66	R:R:K70	7.44	No	No	0	4	5
49	R:R:I67	R:R:K70	5.82	No	No	0	7	5
50	R:R:F336	R:R:I67	8.79	Yes	No	0	8	7
51	R:R:L83	R:R:V68	8.94	No	No	0	6	6
52	R:R:K70	R:R:N71	15.39	No	No	0	5	5
53	R:R:M74	R:R:N71	7.01	Yes	No	0	7	5
54	R:R:H73	R:R:M74	7.88	No	Yes	0	5	7
55	R:R:M74	R:R:N79	5.61	Yes	No	0	7	8
56	R:R:T76	R:R:T78	3.14	No	No	0	7	8
57	R:R:N79	R:R:T76	8.77	No	No	0	8	7
58	R:R:L153	R:R:V77	4.47	Yes	No	0	6	7
59	R:R:E140	R:R:T78	12.7	Yes	No	0	8	8
60	R:R:A136	R:R:F81	4.16	No	Yes	0	7	8
61	R:R:F81	R:R:I137	6.28	Yes	Yes	0	8	9
62	R:R:E140	R:R:F81	7	Yes	Yes	0	8	8
63	R:R:F81	R:R:T161	6.49	Yes	No	0	8	6
64	R:R:F336	R:R:I82	7.54	Yes	No	0	8	8
65	R:R:N84	R:R:T133	8.77	No	No	0	9	8
66	R:R:I162	R:R:N84	12.74	No	No	6	8	9
67	R:R:N84	R:R:W166	5.65	No	Yes	6	9	9
68	R:R:D89	R:R:L85	4.07	Yes	Yes	3	9	9
69	R:R:L85	R:R:T133	5.9	Yes	No	0	9	8
70	R:R:L85	R:R:N325	10.98	Yes	No	3	9	9
71	R:R:A129	R:R:S88	3.42	No	No	0	7	8
72	R:R:S130	R:R:S88	4.89	No	No	0	9	8
73	R:R:D89	R:R:S130	4.42	Yes	No	0	9	9
74	R:R:D89	R:R:S322	8.83	Yes	No	0	9	9
75	R:R:D89	R:R:N325	12.12	Yes	No	3	9	9
76	R:R:F95	R:R:L91	3.65	No	Yes	0	6	7
77	R:R:L91	R:R:S126	6.01	Yes	No	0	7	8
78	R:R:L91	R:R:W166	3.42	Yes	Yes	0	7	9
79	R:R:G93	R:R:V92	3.68	No	Yes	0	7	7
80	R:R:C96	R:R:V92	6.83	No	Yes	0	7	7
81	R:R:S126	R:R:V92	6.46	No	Yes	0	8	7
82	R:R:S322	R:R:V92	8.08	No	Yes	0	9	7
83	R:R:G93	R:R:M97	3.49	No	Yes	0	7	7
84	R:R:F95	R:R:I94	5.02	No	No	0	6	5
85	R:R:F95	R:R:V122	14.42	No	No	0	6	5
86	R:R:C96	R:R:F319	6.98	No	Yes	0	7	7
87	R:R:M97	R:R:P98	3.35	Yes	No	1	7	8
88	R:R:F319	R:R:M97	8.71	Yes	Yes	1	7	7
89	R:R:S119	R:R:T99	6.4	No	No	1	5	6
90	R:R:Q123	R:R:T99	4.25	Yes	No	1	7	6
91	R:R:H315	R:R:T100	8.21	Yes	No	1	6	6
92	R:R:F319	R:R:T100	7.78	Yes	No	1	7	6
93	R:R:L101	R:R:L105	8.3	No	Yes	0	7	5
94	R:R:D103	R:R:P110	6.44	No	No	0	4	3
95	R:R:I106	R:R:L105	8.56	No	Yes	0	4	5
96	R:R:G108	R:R:T107	3.64	No	Yes	0	4	4
97	R:R:T107	R:R:W109	9.7	Yes	Yes	4	4	8
98	R:R:M190	R:R:W109	8.14	No	Yes	4	2	8
99	R:R:W109	R:R:Y198	23.15	Yes	Yes	4	8	2
100	R:R:C116	R:R:P110	5.65	No	No	7	9	3
101	R:R:C203	R:R:P110	9.41	No	No	7	9	3
102	R:R:F111	R:R:T115	15.56	No	No	0	7	6
103	R:R:D112	R:R:N113	4.04	No	No	0	8	3
104	R:R:D112	R:R:T115	5.78	No	No	0	8	6
105	R:R:M118	R:R:T115	4.52	No	No	0	4	6
106	R:R:C116	R:R:L180	3.17	No	No	0	9	5
107	R:R:C116	R:R:C203	7.28	No	No	7	9	9
108	R:R:K117	R:R:L180	5.64	No	No	0	7	5
109	R:R:M118	R:R:S119	3.07	No	No	0	4	5
110	R:R:Q123	R:R:S119	5.78	Yes	No	1	7	5
111	R:R:G120	R:R:Q123	6.58	No	Yes	0	5	7
112	R:R:L121	R:R:M173	4.24	No	No	0	6	7
113	R:R:M125	R:R:W166	3.49	No	Yes	0	6	9
114	R:R:L170	R:R:M125	4.24	No	No	0	4	6
115	R:R:F132	R:R:S128	3.96	No	Yes	0	6	6
116	R:R:I224	R:R:S128	3.1	No	Yes	0	6	6
117	R:R:A129	R:R:W166	5.19	No	Yes	0	7	9
118	R:R:I224	R:R:V131	3.07	No	Yes	0	6	8
119	R:R:P228	R:R:V131	3.53	No	Yes	0	9	8
120	R:R:F279	R:R:V131	5.24	No	Yes	0	9	8
121	R:R:V131	R:R:W283	3.68	Yes	Yes	0	8	8
122	R:R:F132	R:R:I165	8.79	No	No	0	6	7
123	R:R:L134	R:R:Y329	3.52	No	Yes	0	8	9
124	R:R:P228	R:R:V135	3.53	No	No	0	9	7
125	R:R:I232	R:R:V135	6.14	No	No	0	8	7
126	R:R:I137	R:R:R141	3.76	Yes	No	3	9	9
127	R:R:I137	R:R:Y329	7.25	Yes	Yes	3	9	9
128	R:R:A138	R:R:Y236	4	No	Yes	0	9	9
129	R:R:M235	R:R:V139	6.09	No	No	0	7	6
130	R:R:E140	R:R:L153	9.28	Yes	Yes	0	8	6
131	R:R:R141	R:R:Y236	6.17	No	Yes	0	9	9
132	R:R:R141	R:R:Y329	3.09	No	Yes	3	9	9
133	R:R:F142	R:R:R143	4.28	Yes	No	0	8	5
134	R:R:F142	R:R:V146	10.49	Yes	No	0	8	6
135	R:R:F142	R:R:M235	13.68	Yes	No	0	8	7
136	R:R:F142	R:R:R238	3.21	Yes	No	0	8	4
137	R:R:F142	R:R:I239	6.28	Yes	No	0	8	8
138	R:R:E151	R:R:R143	12.79	No	No	0	6	5
139	R:R:I145	R:R:V146	4.61	No	No	0	8	6
140	R:R:I145	R:R:I239	10.3	No	No	0	8	8
141	R:R:I145	R:R:K242	5.82	No	No	0	8	4
142	R:R:H147	R:R:V146	9.69	No	No	0	6	6
143	R:R:H147	R:R:R150	10.16	No	No	0	6	4
144	R:R:F149	R:R:P148	5.78	No	No	8	6	8
145	R:R:P148	R:R:R150	4.32	No	No	8	8	4
146	R:R:F149	R:R:R150	17.1	No	No	8	6	4
147	R:R:R156	R:R:T154	3.88	No	No	0	5	7
148	R:R:K157	R:R:R156	6.19	No	No	0	5	5
149	R:R:R156	R:R:V160	6.54	No	No	0	5	2
150	R:R:I162	R:R:W166	5.87	No	Yes	6	8	9
151	R:R:C174	R:R:L170	3.17	No	No	0	4	4
152	R:R:H223	R:R:I172	11.93	No	No	0	5	5
153	R:R:P175	R:R:Y216	13.91	No	Yes	0	7	6
154	R:R:S176	R:R:Y216	6.36	No	Yes	0	6	6
155	R:R:E205	R:R:T179	8.47	Yes	No	2	4	5
156	R:R:T179	R:R:W207	19.41	No	Yes	2	5	5
157	R:R:E205	R:R:L180	3.98	Yes	No	0	4	5
158	R:R:A206	R:R:T181	5.03	No	No	0	3	5
159	R:R:V182	R:R:Y201	6.31	No	No	0	5	3
160	R:R:C203	R:R:V182	5.12	No	No	0	9	5
161	R:R:E185	R:R:T183	7.06	No	No	5	1	3
162	R:R:S202	R:R:T183	3.2	No	No	5	4	3
163	R:R:E186	R:R:R184	3.49	No	No	0	1	1
164	R:R:E185	R:R:S202	8.62	No	No	5	1	4
165	R:R:H188	R:R:L200	16.71	No	No	0	1	1
166	R:R:F189	R:R:V191	5.24	No	No	0	1	4
167	R:R:F189	R:R:S197	3.96	No	No	0	1	3
168	R:R:M190	R:R:Y198	3.59	No	Yes	4	2	2
169	R:R:L200	R:R:M190	5.65	No	No	0	1	2
170	R:R:N195	R:R:V191	5.91	No	No	0	6	4
171	R:R:D192	R:R:R194	9.53	No	No	0	5	4
172	R:R:R194	R:R:R196	3.2	No	No	0	4	6
173	R:R:P199	R:R:Y198	5.56	No	Yes	0	4	2
174	R:R:Y198	R:R:Y201	9.93	Yes	No	0	2	3
175	R:R:A206	R:R:W204	3.89	No	No	0	3	3
176	R:R:E205	R:R:W207	5.45	Yes	Yes	2	4	5
177	R:R:E205	R:R:R213	4.65	Yes	Yes	2	4	4
178	R:R:P208	R:R:W207	5.4	No	Yes	2	3	5
179	R:R:M212	R:R:W207	10.47	No	Yes	2	3	5
180	R:R:R213	R:R:W207	5	Yes	Yes	2	4	5
181	R:R:W207	R:R:Y216	10.61	Yes	Yes	0	5	6
182	R:R:M212	R:R:P208	5.03	No	No	2	3	3
183	R:R:E209	R:R:G211	4.91	No	No	0	2	3
184	R:R:E209	R:R:M212	9.47	No	No	0	2	3
185	R:R:G211	R:R:K210	3.49	No	No	9	3	1
186	R:R:K210	R:R:R214	3.71	No	Yes	9	1	3
187	R:R:G211	R:R:R214	4.5	No	Yes	9	3	3
188	R:R:D294	R:R:R213	13.1	No	Yes	0	5	4
189	R:R:D294	R:R:R214	4.76	No	Yes	0	5	3
190	R:R:R214	R:R:Y295	9.26	Yes	No	0	3	4
191	R:R:L220	R:R:Y216	7.03	No	Yes	0	5	6
192	R:R:L290	R:R:T217	4.42	No	No	2	5	5
193	R:R:D294	R:R:T217	15.9	No	No	0	5	5
194	R:R:T218	R:R:Y295	4.99	No	No	0	4	4
195	R:R:F221	R:R:Y225	9.28	Yes	Yes	0	6	8
196	R:R:F221	R:R:L226	8.53	Yes	No	0	6	5
197	R:R:F221	R:R:W287	10.02	Yes	Yes	0	6	7
198	R:R:F221	R:R:L291	8.53	Yes	No	0	6	6
199	R:R:L226	R:R:S222	6.01	No	No	0	5	5
200	R:R:I224	R:R:W287	10.57	No	Yes	0	6	7
201	R:R:L229	R:R:Y225	7.03	No	Yes	0	6	8
202	R:R:W283	R:R:Y225	5.79	Yes	Yes	0	8	8
203	R:R:L284	R:R:Y225	10.55	No	Yes	0	5	8
204	R:R:F279	R:R:L229	6.09	No	No	0	9	6
205	R:R:L229	R:R:T280	5.9	No	No	0	6	5
206	R:R:L272	R:R:Y236	16.41	No	Yes	0	8	9
207	R:R:V275	R:R:Y236	3.79	No	Yes	0	8	9
208	R:R:A240	R:R:V269	5.09	No	No	0	5	7
209	R:R:K242	R:R:L243	8.46	No	No	0	4	8
210	R:R:F332	R:R:M271	6.22	No	No	0	6	8
211	R:R:L277	R:R:T280	4.42	No	No	0	5	5
212	R:R:F278	R:R:S282	3.96	Yes	No	10	5	8
213	R:R:F278	R:R:F320	5.36	Yes	No	0	5	5
214	R:R:F278	R:R:N321	7.25	Yes	No	10	5	9
215	R:R:L281	R:R:T280	5.9	No	No	0	6	5
216	R:R:N321	R:R:S282	7.45	No	No	10	9	8
217	R:R:W283	R:R:W287	6.56	Yes	Yes	0	8	7
218	R:R:N321	R:R:W283	9.04	No	Yes	0	9	8
219	R:R:L284	R:R:P285	3.28	No	No	0	5	9
220	R:R:L317	R:R:P285	4.93	No	No	0	7	9
221	R:R:A314	R:R:L286	4.73	No	No	0	6	7
222	R:R:H315	R:R:L286	12.86	Yes	No	0	6	7
223	R:R:A318	R:R:L286	3.15	No	No	0	7	7
224	R:R:L290	R:R:W287	3.42	No	Yes	0	5	7
225	R:R:L289	R:R:V306	5.96	No	Yes	11	5	3
226	R:R:A310	R:R:L289	3.15	No	No	11	5	5
227	R:R:L292	R:R:L298	12.46	No	No	0	4	2
228	R:R:I293	R:R:V306	4.61	No	Yes	0	4	3
229	R:R:L298	R:R:Q302	10.65	No	No	0	2	2
230	R:R:P301	R:R:S299	5.34	No	No	0	4	3
231	R:R:H304	R:R:L305	3.86	No	No	0	2	2
232	R:R:H304	R:R:V308	9.69	No	No	0	2	3
233	R:R:L305	R:R:Y309	3.52	No	No	0	2	1
234	R:R:A310	R:R:V306	3.39	No	Yes	11	5	3
235	R:R:V308	R:R:Y309	12.62	No	No	0	3	1
236	R:R:F311	R:R:H315	9.05	No	Yes	0	4	6
237	R:R:F313	R:R:W316	4.01	No	Yes	0	5	5
238	R:R:F319	R:R:H315	9.05	Yes	Yes	1	7	6
239	R:R:L317	R:R:W316	3.42	No	Yes	0	7	5
240	R:R:F320	R:R:S323	5.28	No	No	0	5	7
241	R:R:I328	R:R:Y329	4.84	No	Yes	0	8	9
242	R:R:R337	R:R:Y331	6.17	No	No	0	8	5
243	R:R:N333	R:R:N335	10.9	No	No	0	8	6
244	R:R:F336	R:R:N333	3.62	Yes	No	0	8	8
245	R:R:E334	R:R:R337	6.98	No	No	0	4	8
246	R:R:N335	R:R:R338	8.44	No	No	0	6	4
247	R:R:C144	R:R:E140	3.04	No	Yes	0	8	8
248	L:L:F8	R:R:G124	3.01	Yes	No	0	0	5
249	R:R:K152	R:R:T154	3	No	No	0	5	7
250	R:R:R213	R:R:W204	3	Yes	No	0	4	3
251	R:R:L91	R:R:V87	2.98	Yes	No	0	7	6
252	R:R:L272	R:R:V268	2.98	No	No	0	8	8
253	R:R:A266	R:R:H270	2.93	No	No	0	5	6
254	R:R:I328	R:R:M274	2.92	No	No	0	8	6
255	R:R:F46	R:R:P312	2.89	No	No	0	5	3
256	R:R:I137	R:R:L85	2.85	Yes	Yes	3	9	9
257	R:R:I293	R:R:L292	2.85	No	No	0	4	4
258	R:R:L155	R:R:M80	2.83	No	No	0	4	5
259	R:R:K157	R:R:L153	2.82	No	Yes	0	5	6
260	R:R:C244	R:R:R241	2.79	No	No	0	5	4
261	R:R:L55	R:R:L56	2.77	No	No	0	5	5
262	R:R:H223	R:R:V219	2.77	No	No	0	5	3
263	R:R:H270	R:R:V269	2.77	No	No	0	6	7
264	R:R:A324	R:R:F278	2.77	No	Yes	0	6	5
265	R:R:L303	R:R:Q297	2.66	No	No	0	3	2
266	R:R:F311	R:R:V306	2.62	No	Yes	0	4	3
267	R:R:H38	R:R:L105	2.57	No	Yes	0	4	5
268	R:R:F132	R:R:L168	2.44	No	No	0	6	4
269	R:R:L153	R:R:R143	2.43	Yes	No	0	6	5
270	R:R:Q245	R:R:R241	2.34	No	No	0	4	4
271	R:R:E334	R:R:R338	2.33	No	No	0	4	4
272	R:R:H75	R:R:R72	2.26	No	No	0	7	6
273	R:R:F332	R:R:R267	2.14	No	No	0	6	7
274	R:R:R184	R:R:Y201	2.06	No	No	0	1	3
275	R:R:A227	R:R:P228	1.87	No	No	0	5	9
276	R:R:A300	R:R:P301	1.87	No	No	0	1	4
277	R:R:A86	R:R:C65	1.81	No	No	0	9	7
278	L:L:P2	L:L:V1	1.77	No	No	0	0	0
279	R:R:P326	R:R:V64	1.77	No	No	0	9	9
280	R:R:G339	R:R:M74	1.75	No	Yes	0	6	7
281	R:R:G124	R:R:M173	1.75	No	No	0	5	7
282	R:R:A169	R:R:S128	1.71	No	Yes	0	8	6
283	R:R:A158	R:R:V77	1.7	No	No	0	7	7
284	L:L:L4	L:L:P5	1.64	No	Yes	0	0	0
285	R:R:G296	R:R:Q297	1.64	No	No	0	3	2
286	R:R:A324	R:R:I327	1.62	No	No	0	6	7
287	R:R:A158	R:R:M80	1.61	No	No	0	7	5
288	R:R:V160	R:R:V164	1.6	No	No	0	2	3
289	R:R:V233	R:R:V234	1.6	No	No	0	4	3
290	R:R:V269	R:R:V273	1.6	No	No	0	7	5
291	R:R:C65	R:R:L83	1.59	No	No	0	7	6
292	R:R:T107	R:R:V102	1.59	Yes	No	0	4	4
293	R:R:T179	R:R:V178	1.59	No	No	0	5	4
294	R:R:T307	R:R:V308	1.59	No	No	0	4	3
295	R:R:A43	R:R:L105	1.58	No	Yes	0	4	5
296	R:R:A288	R:R:L289	1.58	No	No	0	5	5
297	R:R:A114	R:R:N113	1.56	No	No	0	1	3
298	R:R:I172	R:R:S128	1.55	No	Yes	0	5	6
299	R:R:F336	R:R:G330	1.51	Yes	No	0	8	6
300	R:R:L52	R:R:V48	1.49	No	No	0	5	6
301	R:R:L231	R:R:V135	1.49	No	No	0	6	7
302	R:R:L303	R:R:T307	1.47	No	No	0	3	4
303	R:R:M271	R:R:M274	1.44	No	No	0	8	6
304	R:R:I47	R:R:L105	1.43	No	Yes	0	5	5
305	R:R:L159	R:R:M80	1.41	No	No	0	3	5
306	R:R:L52	R:R:L55	1.38	No	No	0	5	5
307	R:R:H75	R:R:V68	1.38	No	No	0	7	6
308	R:R:E185	R:R:L200	1.33	No	No	0	1	1
309	R:R:E186	R:R:H187	1.23	No	No	0	1	3
310	R:R:F66	R:R:L63	1.22	No	No	0	4	6
311	R:R:R264	R:R:R267	1.07	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P5	5.7875	4	0	0
2	L:L:R7	6.59	4	2	0
3	L:L:F8	7.7425	4	0	0
4	L:L:?9	6.48	4	1	0
5	R:R:N61	6.344	5	0	9
6	R:R:M74	5.5625	4	0	7
7	R:R:F81	5.9825	4	0	8
8	R:R:L85	5.95	4	3	9
9	R:R:D89	8.312	5	3	9
10	R:R:L91	4.015	4	0	7
11	R:R:V92	6.2625	4	0	7
12	R:R:M97	5.36167	6	1	7
13	R:R:L105	4.488	5	0	5
14	R:R:T107	7.4775	4	4	4
15	R:R:W109	13.3825	4	4	8
16	R:R:Q123	6.578	5	1	7
17	R:R:S128	2.58	4	0	6
18	R:R:V131	3.88	4	0	8
19	R:R:I137	5.035	4	3	9
20	R:R:E140	8.005	4	0	8
21	R:R:F142	7.588	5	0	8
22	R:R:L153	4.75	4	0	6
23	R:R:W166	4.724	5	6	9
24	R:R:Y198	10.5575	4	4	2
25	R:R:E205	5.44	5	2	4
26	R:R:W207	9.39	6	2	5
27	R:R:R213	6.4375	4	2	4
28	R:R:R214	5.5575	4	9	3
29	R:R:Y216	9.4775	4	0	6
30	R:R:F221	9.09	4	0	6
31	R:R:Y225	8.1625	4	0	8
32	R:R:Y236	7.5925	4	0	9
33	R:R:F278	4.835	4	10	5
34	R:R:W283	6.2675	4	0	8
35	R:R:W287	7.518	5	0	7
36	R:R:V306	4.145	4	11	3
37	R:R:H315	9.106	5	1	6
38	R:R:W316	4.885	4	0	5
39	R:R:F319	7.71	5	1	7
40	R:R:Y329	4.675	4	3	9
41	R:R:F336	5.365	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L200	R:R:M190	17.0799	5.65	No	No	0	1	2
2	R:R:M190	R:R:Y198	18.8232	3.59	No	Yes	4	2	2
3	R:R:Y198	R:R:Y201	35.1227	9.93	Yes	No	0	2	3
4	R:R:V182	R:R:Y201	42.9452	6.31	No	No	0	5	3
5	R:R:C203	R:R:V182	44.8647	5.12	No	No	0	9	5
6	R:R:C116	R:R:C203	20.6608	7.28	No	No	7	9	9
7	R:R:C116	R:R:L180	60.9566	3.17	No	No	0	9	5
8	R:R:E205	R:R:L180	60.3398	3.98	Yes	No	0	4	5
9	R:R:E205	R:R:R213	20.6734	4.65	Yes	Yes	2	4	4
10	R:R:R213	R:R:W204	13.3669	3	Yes	No	0	4	3
11	R:R:C116	R:R:P110	40.6608	5.65	No	No	7	9	3
12	R:R:D103	R:R:P110	66.8722	6.44	No	No	0	4	3
13	L:L:Q6	R:R:D103	66.9163	3.92	No	No	0	0	4
14	L:L:Q6	R:R:Q123	67.1114	6.4	No	Yes	0	0	7
15	L:L:?9	R:R:Q123	71.0132	9.88	Yes	Yes	1	0	7
16	L:L:?9	R:R:H315	11.3153	6.36	Yes	Yes	1	0	6
17	R:R:F311	R:R:H315	36.6583	9.05	No	Yes	0	4	6
18	L:L:P5	R:R:F311	21.5922	13	Yes	No	0	0	4
19	L:L:P5	R:R:T307	16.4191	5.25	Yes	No	0	0	4
20	L:L:F8	L:L:R7	22.9893	11.76	Yes	Yes	0	0	0
21	L:L:R7	R:R:E205	44.078	4.65	Yes	Yes	2	0	4
22	R:R:D294	R:R:R213	10.7741	13.1	No	Yes	0	5	4
23	L:L:R7	R:R:L290	20.6042	6.07	Yes	No	2	0	5
24	L:L:F8	R:R:W287	29.9434	7.02	Yes	Yes	0	0	7
25	R:R:L290	R:R:W287	31.6425	3.42	No	Yes	0	5	7
26	L:L:?9	R:R:F319	60.0944	6.03	Yes	Yes	1	0	7
27	R:R:W109	R:R:Y198	12.3726	23.15	Yes	Yes	4	8	2
28	R:R:F319	R:R:M97	33.7445	8.71	Yes	Yes	1	7	7
29	R:R:M97	R:R:Y50	26.073	4.79	Yes	No	0	7	7
30	R:R:L101	R:R:Y50	24.292	23.45	No	No	0	7	7
31	R:R:L101	R:R:L105	22.4984	8.3	No	Yes	0	7	5
32	R:R:H38	R:R:L105	13.3417	2.57	No	Yes	0	4	5
33	R:R:F221	R:R:W287	28.2819	10.02	Yes	Yes	0	6	7
34	R:R:F221	R:R:Y225	28.9113	9.28	Yes	Yes	0	6	8
35	R:R:L284	R:R:Y225	79.5784	10.55	No	Yes	0	5	8
36	R:R:L284	R:R:P285	78.8798	3.28	No	No	0	5	9
37	R:R:L317	R:R:P285	78.2001	4.93	No	No	0	7	9
38	R:R:L317	R:R:W316	78.2631	3.42	No	Yes	0	7	5
39	R:R:W283	R:R:W287	41.202	6.56	Yes	Yes	0	8	7
40	R:R:W283	R:R:Y225	53.1278	5.79	Yes	Yes	0	8	8
41	R:R:I53	R:R:W316	78.4896	8.22	No	Yes	0	7	5
42	R:R:I53	R:R:M97	78.6973	4.37	No	Yes	0	7	7
43	R:R:F54	R:R:M97	19.1693	7.46	No	Yes	1	6	7
44	R:R:F54	R:R:M58	18.9427	3.73	No	No	0	6	6
45	R:R:N321	R:R:W283	23.7382	9.04	No	Yes	0	9	8
46	R:R:F278	R:R:N321	19.4777	7.25	Yes	No	10	5	9
47	R:R:F278	R:R:F320	13.1278	5.36	Yes	No	0	5	5
48	R:R:F320	R:R:S323	10.9755	5.28	No	No	0	5	7
49	R:R:C57	R:R:M58	18.219	4.86	No	No	0	8	6
50	R:R:C96	R:R:F319	61.0761	6.98	No	Yes	0	7	7
51	R:R:C96	R:R:V92	60.516	6.83	No	Yes	0	7	7
52	R:R:S322	R:R:V92	100	8.08	No	Yes	0	9	7
53	R:R:D89	R:R:S322	99.314	8.83	Yes	No	0	9	9
54	R:R:D89	R:R:N61	16.394	12.12	Yes	Yes	0	9	9
55	R:R:C57	R:R:N61	17.6023	3.15	No	Yes	0	8	9
56	R:R:N61	R:R:P326	10.1133	4.89	Yes	No	0	9	9
57	R:R:A86	R:R:N61	15.0975	4.69	No	Yes	0	9	9
58	R:R:D89	R:R:L85	96.287	4.07	Yes	Yes	3	9	9
59	R:R:I137	R:R:L85	99.5846	2.85	Yes	Yes	3	9	9
60	R:R:F81	R:R:I137	83.4172	6.28	Yes	Yes	0	8	9
61	R:R:E140	R:R:F81	79.9182	7	Yes	Yes	0	8	8
62	R:R:E140	R:R:T78	34.8332	12.7	Yes	No	0	8	8
63	R:R:T76	R:R:T78	33.2347	3.14	No	No	0	7	8
64	R:R:N79	R:R:T76	31.5985	8.77	No	No	0	8	7
65	R:R:M74	R:R:N79	29.9497	5.61	Yes	No	0	7	8
66	R:R:M74	R:R:N71	24.9276	7.01	Yes	No	0	7	5
67	R:R:K70	R:R:N71	23.2284	15.39	No	No	0	5	5
68	R:R:I67	R:R:K70	18.0554	5.82	No	No	0	7	5
69	R:R:F336	R:R:I67	16.3059	8.79	Yes	No	0	8	7
70	R:R:A86	R:R:C65	12.6117	1.81	No	No	0	9	7
71	R:R:C65	R:R:L83	10.1133	1.59	No	No	0	7	6
72	R:R:E140	R:R:L153	50.214	9.28	Yes	Yes	0	8	6
73	R:R:S126	R:R:V92	16.7716	6.46	No	Yes	0	8	7
74	R:R:L91	R:R:S126	15.0975	6.01	Yes	No	0	7	8
75	R:R:L91	R:R:W166	11.1013	3.42	Yes	Yes	0	7	9
76	R:R:G93	R:R:M97	55.28	3.49	No	Yes	0	7	7
77	R:R:Q123	R:R:S119	14.8836	5.78	Yes	No	1	7	5
78	R:R:M118	R:R:S119	12.832	3.07	No	No	0	4	5
79	R:R:M118	R:R:T115	10.7237	4.52	No	No	0	4	6
80	R:R:I224	R:R:W287	32.7565	10.57	No	Yes	0	6	7
81	R:R:I224	R:R:S128	33.0711	3.1	No	Yes	0	6	6
82	R:R:F132	R:R:S128	12.4921	3.96	No	Yes	0	6	6
83	R:R:I224	R:R:V131	16.331	3.07	No	Yes	0	6	8
84	R:R:V131	R:R:W283	22.8068	3.68	Yes	Yes	0	8	8
85	R:R:P228	R:R:V131	15.0661	3.53	No	Yes	0	9	8
86	R:R:I137	R:R:Y329	14.0906	7.25	Yes	Yes	3	9	9
87	R:R:I137	R:R:R141	10.4972	3.76	Yes	No	3	9	9
88	R:R:L153	R:R:R143	31.3908	2.43	Yes	No	0	6	5
89	R:R:F142	R:R:R143	28.0868	4.28	Yes	No	0	8	5
90	R:R:F142	R:R:V146	14.2668	10.49	Yes	No	0	8	6
91	R:R:K157	R:R:L153	10.9817	2.82	No	Yes	0	5	6
92	R:R:I172	R:R:S128	12.4921	1.55	No	Yes	0	5	6
93	R:R:D294	R:R:R214	11.5796	4.76	No	Yes	0	5	3
94	R:R:L229	R:R:Y225	11.5859	7.03	No	Yes	0	6	8
95	R:R:I328	R:R:Y329	10.8811	4.84	No	Yes	0	8	9
96	R:R:F311	R:R:V306	14.6444	2.62	No	Yes	0	4	3
97	R:R:F336	R:R:N333	10.9817	3.62	Yes	No	0	8	8
98	R:R:C203	R:R:P110	26.1045	9.41	No	No	7	9	3
99	R:R:E205	R:R:W207	18.4393	5.45	Yes	Yes	2	4	5
100	R:R:F319	R:R:H315	31.5481	9.05	Yes	Yes	1	7	6
101	R:R:G93	R:R:V92	54.6444	3.68	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P2	R:R:W204	14.86	0	No	No	0	3	0	1
L:L:N3	R:R:S202	8.94	0	No	No	0	4	0	1
L:L:P5	R:R:N104	3.26	0	Yes	No	0	4	0	1
L:L:P5	R:R:T307	5.25	0	Yes	No	0	4	0	1
L:L:P5	R:R:F311	13	0	Yes	No	0	4	0	1
L:L:Q6	R:R:D103	3.92	0	No	No	0	4	0	1
L:L:Q6	R:R:Q123	6.4	0	No	Yes	0	7	0	1
L:L:R7	R:R:E205	4.65	2	Yes	Yes	0	4	0	1
L:L:R7	R:R:T217	3.88	2	Yes	No	0	5	0	1
L:L:R7	R:R:L290	6.07	2	Yes	No	0	5	0	1
L:L:F8	R:R:V127	9.18	0	Yes	No	0	7	0	1
L:L:F8	R:R:W287	7.02	0	Yes	Yes	0	7	0	1
L:L:?9	R:R:T100	3.65	1	Yes	No	0	6	0	1
L:L:?9	R:R:Q123	9.88	1	Yes	Yes	0	7	0	1
L:L:?9	R:R:H315	6.36	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F319	6.03	1	Yes	Yes	0	7	0	1
R:R:C96	R:R:F319	6.98	0	No	Yes	7	7	2	1
R:R:F319	R:R:M97	8.71	1	Yes	Yes	7	7	1	2
R:R:S119	R:R:T99	6.4	1	No	No	5	6	2	2
R:R:Q123	R:R:T99	4.25	1	Yes	No	7	6	1	2
R:R:H315	R:R:T100	8.21	1	Yes	No	6	6	1	1
R:R:F319	R:R:T100	7.78	1	Yes	No	7	6	1	1
R:R:D103	R:R:P110	6.44	0	No	No	4	3	1	2
R:R:Q123	R:R:S119	5.78	1	Yes	No	7	5	1	2
R:R:G120	R:R:Q123	6.58	0	No	Yes	5	7	2	1
R:R:E205	R:R:T179	8.47	2	Yes	No	4	5	1	2
R:R:T179	R:R:W207	19.41	2	No	Yes	5	5	2	2
R:R:E205	R:R:L180	3.98	2	Yes	No	4	5	1	2
R:R:E185	R:R:T183	7.06	5	No	No	1	3	2	2
R:R:S202	R:R:T183	3.2	5	No	No	4	3	1	2
R:R:E185	R:R:S202	8.62	5	No	No	1	4	2	1
R:R:A206	R:R:W204	3.89	0	No	No	3	3	2	1
R:R:E205	R:R:W207	5.45	2	Yes	Yes	4	5	1	2
R:R:E205	R:R:R213	4.65	2	Yes	Yes	4	4	1	2
R:R:R213	R:R:W207	5	2	Yes	Yes	4	5	2	2
R:R:D294	R:R:R213	13.1	0	No	Yes	5	4	2	2
R:R:L290	R:R:T217	4.42	2	No	No	5	5	1	1
R:R:D294	R:R:T217	15.9	0	No	No	5	5	2	1
R:R:F221	R:R:W287	10.02	0	Yes	Yes	6	7	2	1
R:R:I224	R:R:W287	10.57	0	No	Yes	6	7	2	1
R:R:W283	R:R:W287	6.56	0	Yes	Yes	8	7	2	1
R:R:H315	R:R:L286	12.86	1	Yes	No	6	7	1	2
R:R:L290	R:R:W287	3.42	2	No	Yes	5	7	1	1
R:R:F311	R:R:H315	9.05	0	No	Yes	4	6	1	1
R:R:F319	R:R:H315	9.05	1	Yes	Yes	7	6	1	1
L:L:F8	R:R:G124	3.01	0	Yes	No	0	5	0	1
R:R:R213	R:R:W204	3	2	Yes	No	4	3	2	1
R:R:F311	R:R:V306	2.62	0	No	Yes	4	3	1	2
R:R:G124	R:R:M173	1.75	0	No	No	5	7	1	2
R:R:T307	R:R:V308	1.59	0	No	No	4	3	1	2
R:R:L303	R:R:T307	1.47	0	No	No	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M0R_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	285
Number of Links	311
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	11
Number of Nodes involved in Communities	51
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	46258
Length Of Smallest Path	3
Average Path Length	15.1542
Length of Longest Path	38
Minimum Path Strength	1.435
Average Path Strength	6.33251
Maximum Path Strength	16.425
Minimum Path Correlation	0.7
Average Path Correlation	0.926471
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.4406
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.0723
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ6
Sequence	>9M0R_nogp_Chain_R L T F S S Y Y Q H T S P V A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N R H M H T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T G W P F D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H P F R E K L T L R K A L V T I A V I W A L A L L I M C P S A V T L T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G Q L S A P Q L H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F R R G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M0R	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-	Gi1/β1/γ2	2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M0R (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-		2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9VI9	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	RFRP-3	-	Gi1/β1/γ2	3.02	2025-12-03	10.1093/procel/pwaf090
	9VI9 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	RFRP-3	-		3.02	2025-12-03	10.1093/procel/pwaf090
	9VIF	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-	Gi1/β1/γ2	3.19	2025-12-03	10.1093/procel/pwaf090
	9VIF (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-		3.19	2025-12-03	10.1093/procel/pwaf090

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9M0R_nogp.zip

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