psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C16	L:L:C21	7.28	No	No	0	0	0
2	L:L:C16	R:R:Y292	9.41	No	Yes	0	0	6
3	L:L:R17	R:R:Y292	3.09	No	Yes	0	0	6
4	L:L:F18	R:R:C299	2.79	No	No	0	0	4
5	L:L:T20	R:R:Y227	3.75	No	Yes	1	0	8
6	L:L:T20	R:R:I298	4.56	No	No	1	0	7
7	L:L:T20	R:R:F349	6.49	No	Yes	1	0	8
8	L:L:C21	L:L:K25	3.23	No	No	0	0	0
9	L:L:C21	R:R:H295	13.27	No	No	0	0	6
10	L:L:K25	L:L:T22	3	No	Yes	0	0	0
11	L:L:T22	R:R:M369	3.01	Yes	No	1	0	8
12	L:L:T22	R:R:H370	6.85	Yes	Yes	1	0	7
13	L:L:T22	R:R:M373	3.01	Yes	No	1	0	7
14	L:L:V23	R:R:H219	2.77	No	Yes	0	0	6
15	L:L:Q24	R:R:Q216	5.12	No	Yes	3	0	6
16	L:L:Q24	R:R:L220	5.32	No	Yes	3	0	7
17	L:L:Q24	R:R:L291	7.99	No	No	0	0	5
18	L:L:K25	R:R:S286	3.06	No	No	0	0	7
19	L:L:I30	L:L:L26	5.71	Yes	No	0	0	0
20	L:L:L26	R:R:T145	2.95	No	No	0	0	7
21	L:L:A27	R:R:I284	3.25	No	No	0	0	6
22	L:L:H28	L:L:Q32	21.02	No	No	0	0	0
23	L:L:H28	R:R:S286	9.76	No	No	0	0	7
24	L:L:H28	R:R:D287	8.82	No	No	0	0	3
25	L:L:F33	L:L:Q29	3.51	Yes	No	0	0	0
26	L:L:I30	L:L:T34	3.04	Yes	No	4	0	0
27	L:L:I30	R:R:F142	8.79	Yes	No	0	0	6
28	L:L:I30	R:R:A199	3.25	Yes	No	0	0	4
29	L:L:I30	R:R:N200	4.25	Yes	No	4	0	3
30	L:L:Y31	R:R:Q202	6.76	No	No	0	0	2
31	L:L:Y31	R:R:V205	10.09	No	No	0	0	4
32	L:L:Y31	R:R:I284	10.88	No	No	0	0	6
33	L:L:F33	L:L:Q32	7.03	Yes	No	5	0	0
34	L:L:Q32	R:R:P97	20.53	No	No	5	0	3
35	L:L:F33	R:R:D96	9.55	Yes	No	0	0	5
36	L:L:F33	R:R:P97	2.89	Yes	No	5	0	3
37	L:L:F33	R:R:V135	7.87	Yes	No	0	0	1
38	L:L:T34	R:R:N200	4.39	No	No	4	0	3
39	L:L:T34	R:R:Q202	5.67	No	No	0	0	2
40	L:L:D35	L:L:D37	3.99	No	No	0	0	0
41	L:L:D35	R:R:Q202	9.14	No	No	0	0	2
42	L:L:K38	R:R:Q93	5.42	No	No	0	0	4
43	L:L:D39	L:L:P43	4.83	No	No	0	0	0
44	L:L:R44	L:L:V41	3.92	No	No	0	0	0
45	L:L:V41	R:R:D94	2.92	No	No	0	0	5
46	L:L:A42	R:R:F92	2.77	No	Yes	2	0	6
47	L:L:A42	R:R:D94	3.09	No	No	0	0	5
48	L:L:A42	R:R:F95	2.77	No	Yes	2	0	5
49	L:L:P43	R:R:F92	14.45	No	Yes	0	0	6
50	L:L:S45	L:L:Y52	11.45	No	Yes	0	0	0
51	L:L:K46	R:R:W72	4.64	Yes	Yes	2	0	5
52	L:L:K46	R:R:Y124	5.97	Yes	Yes	2	0	4
53	L:L:K46	R:R:T125	6.01	Yes	No	0	0	6
54	L:L:K46	R:R:N128	11.19	Yes	No	0	0	3
55	L:L:P49	L:L:S48	3.56	No	No	6	0	0
56	L:L:Q50	L:L:S48	10.11	No	No	6	0	0
57	L:L:P49	L:L:Q50	4.74	No	No	6	0	0
58	L:L:P49	R:R:H114	6.1	No	Yes	0	0	4
59	E:E:Y83	L:L:Q50	3.38	No	No	0	6	0
60	L:L:Y52	R:R:G71	4.35	Yes	Yes	2	0	4
61	L:L:Y52	R:R:W72	12.54	Yes	Yes	2	0	5
62	E:E:W84	L:L:Y52	9.65	Yes	Yes	2	9	0
63	E:E:P85	L:L:Y52	4.17	No	Yes	2	9	0
64	R:R:F92	R:R:T37	6.49	Yes	No	0	6	4
65	R:R:M42	R:R:R38	4.96	No	No	2	3	5
66	E:E:E67	R:R:R38	13.96	No	No	2	4	5
67	R:R:N39	R:R:T43	4.39	No	No	0	5	5
68	R:R:D90	R:R:K40	4.15	No	No	0	3	5
69	R:R:K40	R:R:Y91	8.36	No	Yes	0	5	5
70	R:R:I41	R:R:M42	2.92	No	No	2	6	3
71	R:R:I41	R:R:W72	4.7	No	Yes	2	6	5
72	R:R:I41	R:R:Y91	13.3	No	Yes	2	6	5
73	E:E:E67	R:R:M42	23.01	No	No	2	4	3
74	E:E:I63	R:R:T43	3.04	No	No	0	6	5
75	R:R:Q45	R:R:W69	13.14	No	Yes	0	5	7
76	E:E:Y66	R:R:Q45	11.27	No	No	0	9	5
77	E:E:T70	R:R:Q45	4.25	No	No	0	9	5
78	R:R:Q50	R:R:Y46	27.05	No	Yes	7	4	2
79	E:E:L59	R:R:Y46	4.69	No	Yes	0	7	2
80	E:E:F62	R:R:Y46	10.32	No	Yes	0	8	2
81	E:E:H97	R:R:Y46	7.62	No	Yes	7	9	2
82	E:E:V106	R:R:E47	5.7	Yes	No	0	4	6
83	R:R:C48	R:R:W69	5.22	No	Yes	0	9	7
84	R:R:C48	R:R:C74	7.28	No	No	0	9	9
85	R:R:I52	R:R:Y49	9.67	No	No	0	5	3
86	R:R:W69	R:R:Y49	3.86	Yes	No	0	7	3
87	E:E:H97	R:R:Q50	3.71	No	No	7	9	4
88	E:E:V106	R:R:Q50	7.16	Yes	No	0	4	4
89	E:E:V106	R:R:K51	9.11	Yes	No	0	4	3
90	E:E:R108	R:R:K51	4.95	No	No	0	4	3
91	R:R:I52	R:R:R67	8.77	No	No	0	5	4
92	E:E:R98	R:R:M53	6.2	No	No	0	6	2
93	E:E:V106	R:R:Q54	5.73	Yes	No	0	4	2
94	R:R:C105	R:R:C65	7.28	No	No	2	9	9
95	R:R:C65	R:R:W111	9.14	No	Yes	2	9	9
96	R:R:N76	R:R:R67	10.85	No	No	0	6	4
97	R:R:D77	R:R:R67	13.1	No	No	0	4	4
98	R:R:T68	R:R:W111	13.34	No	Yes	0	5	9
99	R:R:G71	R:R:W69	8.44	Yes	Yes	2	4	7
100	E:E:W84	R:R:W69	3.75	Yes	Yes	2	9	7
101	R:R:D70	R:R:G71	5.03	Yes	Yes	2	9	4
102	R:R:D70	R:R:L73	6.79	Yes	No	2	9	5
103	R:R:D70	R:R:W75	13.4	Yes	Yes	2	9	9
104	R:R:D70	R:R:Y124	8.05	Yes	Yes	2	9	4
105	E:E:W84	R:R:G71	2.81	Yes	Yes	2	9	4
106	R:R:W72	R:R:Y91	6.75	Yes	Yes	2	5	5
107	R:R:F92	R:R:W72	3.01	Yes	Yes	2	6	5
108	R:R:F95	R:R:W72	4.01	Yes	Yes	2	5	5
109	R:R:W72	R:R:Y124	10.61	Yes	Yes	2	5	4
110	R:R:L73	R:R:P89	9.85	No	No	0	5	8
111	R:R:L73	R:R:Y124	3.52	No	Yes	2	5	4
112	R:R:Q86	R:R:W75	6.57	No	Yes	0	5	9
113	R:R:K103	R:R:W75	20.89	Yes	Yes	2	8	9
114	R:R:W111	R:R:W75	7.5	Yes	Yes	2	9	9
115	R:R:T122	R:R:W75	3.64	No	Yes	2	7	9
116	R:R:W75	R:R:Y124	2.89	Yes	Yes	2	9	4
117	R:R:E83	R:R:T82	2.82	No	No	0	3	5
118	R:R:K103	R:R:S84	9.18	Yes	No	0	8	7
119	R:R:M85	R:R:T102	6.02	No	No	0	4	5
120	R:R:K100	R:R:L87	7.05	No	No	0	3	4
121	R:R:C88	R:R:P89	3.77	Yes	No	0	9	8
122	R:R:C88	R:R:F95	8.38	Yes	Yes	2	9	5
123	R:R:C88	R:R:V101	3.42	Yes	No	0	9	7
124	R:R:C127	R:R:C88	7.28	No	Yes	2	9	9
125	R:R:P89	R:R:Y91	9.74	No	Yes	0	8	5
126	R:R:F92	R:R:Y91	6.19	Yes	Yes	2	6	5
127	R:R:F92	R:R:F95	8.57	Yes	Yes	2	6	5
128	R:R:D94	R:R:T131	2.89	No	No	0	5	1
129	R:R:C127	R:R:F95	4.19	No	Yes	2	9	5
130	R:R:F95	R:R:N128	6.04	Yes	No	0	5	3
131	R:R:D96	R:R:T131	13.01	No	No	0	5	1
132	R:R:D96	R:R:K134	4.15	No	No	0	5	3
133	R:R:E99	R:R:Q126	5.1	No	No	0	5	5
134	R:R:V101	R:R:Y124	10.09	No	Yes	0	7	4
135	R:R:Q126	R:R:V101	5.73	No	No	0	5	7
136	R:R:Q126	R:R:T102	2.83	No	No	0	5	5
137	R:R:C105	R:R:K103	4.85	No	Yes	2	9	8
138	R:R:K103	R:R:W111	13.92	Yes	Yes	2	8	9
139	R:R:K103	R:R:T122	6.01	Yes	No	2	8	7
140	R:R:D106	R:R:I104	4.2	No	No	0	5	4
141	R:R:F112	R:R:I104	3.77	No	No	0	5	4
142	R:R:C105	R:R:W111	5.22	No	Yes	2	9	9
143	R:R:N110	R:R:R113	4.82	No	No	0	5	1
144	R:R:R113	R:R:W111	3	No	Yes	0	1	9
145	R:R:T120	R:R:W111	9.7	No	Yes	0	5	9
146	R:R:F112	R:R:H114	4.53	No	Yes	0	5	4
147	R:R:H114	R:R:P115	7.63	Yes	No	0	4	3
148	R:R:H114	R:R:S117	4.18	Yes	No	0	4	4
149	R:R:H114	R:R:W121	29.62	Yes	No	0	4	8
150	E:E:Y83	R:R:S117	5.09	No	No	0	6	4
151	E:E:Y83	R:R:R119	10.29	No	No	0	6	4
152	R:R:N123	R:R:W121	6.78	No	No	0	8	8
153	R:R:T122	R:R:Y124	9.99	No	Yes	2	7	4
154	R:R:N130	R:R:V129	7.39	No	No	0	2	2
155	R:R:E133	R:R:H132	11.08	No	No	0	1	2
156	R:R:E133	R:R:K136	5.4	No	No	0	1	2
157	R:R:K136	R:R:N140	4.2	No	No	0	2	4
158	R:R:L141	R:R:T137	2.95	No	No	1	6	4
159	R:R:T137	R:R:Y367	4.99	No	No	1	4	6
160	R:R:L139	R:R:Y143	4.69	No	No	0	3	4
161	R:R:L141	R:R:Y367	4.69	No	No	1	6	6
162	R:R:H370	R:R:L141	11.57	Yes	No	1	7	6
163	R:R:F142	R:R:I146	3.77	No	No	0	6	6
164	R:R:F142	R:R:L195	7.31	No	No	0	6	7
165	R:R:I371	R:R:L144	2.85	No	No	0	6	6
166	R:R:H370	R:R:T145	5.48	Yes	No	1	7	7
167	R:R:H374	R:R:T145	19.17	No	No	1	9	7
168	R:R:F375	R:R:G148	9.03	No	No	0	7	9
169	R:R:H149	R:R:S188	13.95	Yes	No	0	7	8
170	R:R:H149	R:R:T191	6.85	Yes	No	0	7	7
171	R:R:H149	R:R:I192	3.98	Yes	No	0	7	6
172	R:R:H149	R:R:H374	10.75	Yes	No	0	7	9
173	R:R:G150	R:R:I153	3.53	No	Yes	0	7	6
174	R:R:G377	R:R:S152	3.71	No	No	0	9	9
175	R:R:I153	R:R:L157	2.85	Yes	No	0	6	3
176	R:R:I153	R:R:S188	4.64	Yes	No	0	6	8
177	R:R:I153	R:R:V189	4.61	Yes	No	0	6	4
178	R:R:L378	R:R:S155	4.5	No	No	0	6	6
179	R:R:S155	R:R:S381	6.52	No	Yes	0	6	8
180	R:R:F181	R:R:L156	7.31	Yes	Yes	1	8	9
181	R:R:F184	R:R:L156	6.09	Yes	Yes	1	8	9
182	R:R:L156	R:R:V185	4.47	Yes	No	0	9	7
183	R:R:G377	R:R:L156	5.13	No	Yes	1	9	9
184	R:R:L156	R:R:S381	6.01	Yes	Yes	1	9	8
185	R:R:L157	R:R:V185	5.96	No	No	0	3	7
186	R:R:F386	R:R:I158	3.77	Yes	No	0	8	5
187	R:R:F181	R:R:S159	5.28	Yes	Yes	1	8	8
188	R:R:S159	R:R:S381	4.89	Yes	Yes	1	8	8
189	R:R:C385	R:R:S159	6.89	Yes	Yes	1	9	8
190	R:R:F386	R:R:S159	5.28	Yes	Yes	1	8	8
191	R:R:F181	R:R:L160	3.65	Yes	No	0	8	5
192	R:R:F166	R:R:I162	5.02	Yes	No	1	7	8
193	R:R:C385	R:R:I162	3.27	Yes	No	1	9	8
194	R:R:I162	R:R:L395	2.85	No	No	1	8	5
195	R:R:F163	R:R:I174	3.77	No	Yes	1	7	9
196	R:R:F163	R:R:K178	3.72	No	No	1	7	6
197	R:R:C385	R:R:F163	5.59	Yes	No	1	9	7
198	R:R:F164	R:R:K178	14.89	No	No	0	4	6
199	R:R:F166	R:R:Y165	9.28	Yes	No	0	7	3
200	R:R:F166	R:R:I394	5.02	Yes	No	0	7	8
201	R:R:F166	R:R:L395	3.65	Yes	No	1	7	5
202	R:R:K167	R:R:S170	3.06	No	No	0	7	7
203	R:R:I174	R:R:L169	4.28	Yes	No	0	9	9
204	R:R:I394	R:R:L169	2.85	No	No	0	8	9
205	R:R:C171	R:R:R173	2.79	No	Yes	1	8	9
206	R:R:C171	R:R:I174	3.27	No	Yes	1	8	9
207	R:R:C171	R:R:E248	4.56	No	No	0	8	6
208	R:R:Q172	R:R:Y236	7.89	Yes	Yes	1	7	8
209	R:R:E248	R:R:Q172	6.37	No	Yes	0	6	7
210	R:R:Q172	R:R:Q250	6.4	Yes	Yes	1	7	6
211	R:R:L252	R:R:Q172	9.32	Yes	Yes	1	6	7
212	R:R:I174	R:R:R173	3.76	Yes	Yes	1	9	9
213	R:R:H177	R:R:R173	5.64	No	Yes	0	9	9
214	R:R:R173	R:R:Y236	3.09	Yes	Yes	1	9	8
215	R:R:N388	R:R:R173	3.62	No	Yes	1	9	9
216	R:R:E390	R:R:R173	5.82	No	Yes	1	9	9
217	R:R:I174	R:R:K178	5.82	Yes	No	1	9	6
218	R:R:L252	R:R:T175	2.95	Yes	No	0	6	6
219	R:R:L176	R:R:W229	3.42	Yes	Yes	1	9	9
220	R:R:E233	R:R:L176	3.98	Yes	Yes	0	9	9
221	R:R:L176	R:R:Y236	8.21	Yes	Yes	1	9	8
222	R:R:L176	R:R:L252	4.15	Yes	Yes	1	9	6
223	R:R:L176	R:R:Y255	3.52	Yes	Yes	1	9	8
224	R:R:E233	R:R:H177	11.08	Yes	No	0	9	9
225	R:R:F384	R:R:H177	4.53	Yes	No	0	8	9
226	R:R:N179	R:R:W229	16.95	No	Yes	1	8	9
227	R:R:N179	R:R:Y256	15.12	No	No	1	8	5
228	R:R:N179	R:R:W260	5.65	No	Yes	1	8	9
229	R:R:F181	R:R:L180	4.87	Yes	No	0	8	9
230	R:R:F184	R:R:L180	6.09	Yes	No	0	8	9
231	R:R:E233	R:R:L180	3.98	Yes	No	0	9	9
232	R:R:F181	R:R:S381	5.28	Yes	Yes	1	8	8
233	R:R:C186	R:R:F182	8.38	No	No	0	7	4
234	R:R:F182	R:R:W260	4.01	No	Yes	0	4	9
235	R:R:S183	R:R:W229	4.94	No	Yes	1	8	9
236	R:R:S183	R:R:W260	7.41	No	Yes	1	8	9
237	R:R:F184	R:R:N226	22.96	Yes	No	1	8	8
238	R:R:F184	R:R:M230	3.73	Yes	Yes	1	8	9
239	R:R:F184	R:R:Q376	12.88	Yes	Yes	1	8	9
240	R:R:F184	R:R:G377	3.01	Yes	No	1	8	9
241	R:R:C186	R:R:L222	4.76	No	Yes	0	7	5
242	R:R:N187	R:R:T191	4.39	No	No	0	8	7
243	R:R:M223	R:R:N187	4.21	No	No	0	6	8
244	R:R:N187	R:R:N226	14.98	No	No	0	8	8
245	R:R:I193	R:R:V189	3.07	No	No	0	5	4
246	R:R:H219	R:R:V190	4.15	Yes	No	0	6	6
247	R:R:L222	R:R:V190	2.98	Yes	No	0	5	6
248	R:R:H219	R:R:T191	8.21	Yes	No	0	6	7
249	R:R:H194	R:R:V198	9.69	No	No	0	7	6
250	R:R:H194	R:R:S215	4.18	No	No	0	7	6
251	R:R:H194	R:R:Q216	6.18	No	Yes	0	7	6
252	R:R:C212	R:R:V198	3.42	No	No	0	9	6
253	R:R:L204	R:R:P209	4.93	No	No	0	4	5
254	R:R:C282	R:R:V205	10.25	No	No	0	9	4
255	R:R:K213	R:R:N208	6.99	No	No	0	8	6
256	R:R:N208	R:R:N281	16.35	No	No	0	6	4
257	R:R:C212	R:R:P209	3.77	No	No	0	9	5
258	R:R:C212	R:R:C282	7.28	No	No	0	9	9
259	R:R:K213	R:R:N279	6.99	No	No	0	8	6
260	R:R:K213	R:R:W283	20.89	No	Yes	0	8	8
261	R:R:I218	R:R:V214	3.07	No	No	0	5	4
262	R:R:L220	R:R:Q216	11.98	Yes	Yes	3	7	6
263	R:R:Q216	R:R:W283	7.67	Yes	Yes	3	6	8
264	R:R:A267	R:R:F217	4.16	No	No	0	6	6
265	R:R:C268	R:R:F217	4.19	No	No	0	2	6
266	R:R:A271	R:R:F217	2.77	No	No	0	5	6
267	R:R:I218	R:R:L222	2.85	No	Yes	0	5	5
268	R:R:H219	R:R:L220	5.14	Yes	Yes	0	6	7
269	R:R:H270	R:R:L220	5.14	Yes	Yes	3	8	7
270	R:R:I294	R:R:L220	9.99	No	Yes	3	7	7
271	R:R:L222	R:R:Y221	3.52	Yes	Yes	1	5	8
272	R:R:C225	R:R:Y221	9.41	Yes	Yes	1	8	8
273	R:R:P263	R:R:Y221	4.17	Yes	Yes	1	9	8
274	R:R:L264	R:R:Y221	14.07	No	Yes	0	3	8
275	R:R:C225	R:R:L222	3.17	Yes	Yes	1	8	5
276	R:R:G224	R:R:P263	4.06	No	Yes	0	5	9
277	R:R:C225	R:R:W260	5.22	Yes	Yes	1	8	9
278	R:R:C225	R:R:P263	7.53	Yes	Yes	1	8	9
279	R:R:M230	R:R:N226	4.21	Yes	No	1	9	8
280	R:R:M230	R:R:Y227	5.99	Yes	Yes	1	9	8
281	R:R:I298	R:R:Y227	13.3	No	Yes	1	7	8
282	R:R:F349	R:R:Y227	9.28	Yes	Yes	1	8	8
283	R:R:F228	R:R:L258	3.65	Yes	Yes	0	5	6
284	R:R:F228	R:R:F262	6.43	Yes	No	1	5	4
285	R:R:F228	R:R:P263	2.89	Yes	Yes	1	5	9
286	R:R:F228	R:R:P297	2.89	Yes	Yes	1	5	8
287	E:E:T130	R:R:F228	7.78	No	Yes	1	9	5
288	R:R:C232	R:R:W229	7.84	No	Yes	0	7	9
289	R:R:W229	R:R:Y256	2.89	Yes	No	1	9	5
290	R:R:G259	R:R:W229	8.44	No	Yes	0	9	9
291	R:R:W229	R:R:W260	19.68	Yes	Yes	1	9	9
292	R:R:M230	R:R:Q376	6.8	Yes	Yes	1	9	9
293	R:R:I235	R:R:L231	5.71	Yes	Yes	0	6	8
294	R:R:L231	R:R:L258	2.77	Yes	Yes	0	8	6
295	R:R:A301	R:R:L231	6.3	No	Yes	0	7	8
296	R:R:L231	R:R:V304	2.98	Yes	No	0	8	6
297	R:R:C232	R:R:L258	4.76	No	Yes	0	7	6
298	R:R:E233	R:R:L344	10.6	Yes	No	0	9	9
299	R:R:G234	R:R:N305	3.39	No	No	0	8	9
300	R:R:I235	R:R:Y255	4.84	Yes	Yes	1	6	8
301	R:R:F308	R:R:I235	5.02	Yes	Yes	0	8	6
302	E:E:V137	R:R:I235	3.07	No	Yes	1	9	6
303	E:E:V138	R:R:I235	6.14	No	Yes	0	9	6
304	R:R:L240	R:R:Y236	14.07	No	Yes	0	8	8
305	R:R:Q250	R:R:Y236	5.64	Yes	Yes	1	6	8
306	R:R:Y236	R:R:Y255	4.96	Yes	Yes	1	8	8
307	R:R:I241	R:R:L237	2.85	No	No	8	8	9
308	R:R:I312	R:R:L237	5.71	No	No	8	9	9
309	R:R:H238	R:R:V242	13.84	Yes	No	0	8	6
310	R:R:H238	R:R:V243	2.77	Yes	No	0	8	5
311	R:R:F308	R:R:H238	22.63	Yes	Yes	0	8	8
312	R:R:H238	R:R:N311	3.83	Yes	No	0	8	7
313	R:R:I241	R:R:I312	2.94	No	No	8	8	9
314	R:R:I241	R:R:V315	3.07	No	No	0	8	8
315	R:R:V243	R:R:V245	3.21	No	No	0	5	7
316	E:E:K142	R:R:V243	3.04	No	No	0	8	5
317	R:R:Q250	R:R:V245	4.3	Yes	No	0	6	7
318	R:R:F246	R:R:K249	3.72	No	No	0	6	5
319	R:R:A247	R:R:E248	4.53	No	No	0	6	6
320	R:R:Q250	R:R:Y255	7.89	Yes	Yes	1	6	8
321	E:E:S141	R:R:Q250	10.11	No	Yes	1	9	6
322	R:R:H251	R:R:M253	9.19	No	No	0	4	3
323	E:E:R140	R:R:H251	3.39	No	No	0	8	4
324	R:R:L252	R:R:Y255	4.69	Yes	Yes	1	6	8
325	E:E:V137	R:R:W254	3.68	No	No	0	9	2
326	E:E:R140	R:R:W254	11	No	No	0	8	2
327	E:E:V137	R:R:Y255	3.79	No	Yes	1	9	8
328	E:E:S141	R:R:Y255	5.09	No	Yes	1	9	8
329	E:E:M133	R:R:F257	3.73	No	No	0	9	3
330	E:E:M133	R:R:L258	4.24	No	Yes	0	9	6
331	E:E:T130	R:R:F262	6.49	No	No	1	9	4
332	E:E:M133	R:R:F262	13.68	No	No	0	9	4
333	R:R:I265	R:R:P266	3.39	No	No	0	4	6
334	R:R:I265	R:R:I269	2.94	No	No	0	4	5
335	R:R:P266	R:R:P297	3.9	No	Yes	0	6	8
336	R:R:I269	R:R:I293	2.94	No	Yes	3	5	8
337	E:E:L122	R:R:I269	4.28	No	No	3	9	5
338	R:R:H270	R:R:R274	11.28	Yes	Yes	3	8	7
339	R:R:H270	R:R:L291	3.86	Yes	No	0	8	5
340	R:R:H270	R:R:I293	3.98	Yes	Yes	3	8	8
341	R:R:H270	R:R:I294	5.3	Yes	No	3	8	7
342	R:R:I272	R:R:L276	2.85	No	No	0	4	3
343	R:R:A273	R:R:L290	3.15	No	Yes	0	5	3
344	R:R:D280	R:R:R274	10.72	Yes	Yes	3	4	7
345	R:R:R274	R:R:W283	23.99	Yes	Yes	3	7	8
346	R:R:L290	R:R:R274	3.64	Yes	Yes	0	3	7
347	R:R:S275	R:R:W283	4.94	No	Yes	0	3	8
348	E:E:P114	R:R:Y277	2.78	Yes	No	0	9	3
349	R:R:D280	R:R:Y278	5.75	Yes	Yes	3	4	6
350	R:R:S285	R:R:Y278	3.82	No	Yes	3	5	6
351	R:R:T288	R:R:Y278	17.48	No	Yes	0	5	6
352	E:E:L111	R:R:Y278	7.03	No	Yes	3	4	6
353	R:R:D280	R:R:W283	4.47	Yes	Yes	3	4	8
354	R:R:D280	R:R:S285	5.89	Yes	No	3	4	5
355	E:E:L111	R:R:D280	6.79	No	Yes	3	4	4
356	R:R:L290	R:R:T288	5.9	Yes	No	0	3	5
357	E:E:D113	R:R:T288	4.34	No	No	0	9	5
358	R:R:H289	R:R:Y292	17.42	No	Yes	0	4	6
359	E:E:D113	R:R:H289	11.35	No	No	0	9	4
360	E:E:L119	R:R:H289	3.86	Yes	No	0	9	4
361	R:R:I293	R:R:L290	2.85	Yes	Yes	0	8	3
362	E:E:L119	R:R:L290	2.77	Yes	Yes	0	9	3
363	R:R:H295	R:R:L291	3.86	No	No	0	6	5
364	E:E:I123	R:R:Y292	6.04	No	Yes	0	9	6
365	E:E:L122	R:R:I293	2.85	No	Yes	3	9	8
366	R:R:G296	R:R:P297	4.06	No	Yes	0	4	8
367	E:E:P126	R:R:P297	3.9	No	Yes	0	9	8
368	E:E:T130	R:R:P297	5.25	No	Yes	1	9	8
369	R:R:I298	R:R:L302	2.85	No	No	0	7	7
370	R:R:F349	R:R:L302	6.09	Yes	No	0	8	7
371	R:R:F308	R:R:V304	5.24	Yes	No	0	8	6
372	R:R:L345	R:R:N305	13.73	Yes	No	0	9	9
373	R:R:I347	R:R:L306	4.28	No	No	0	7	5
374	R:R:F307	R:R:F308	5.36	No	Yes	0	4	8
375	R:R:F307	R:R:N311	15.71	No	No	0	4	7
376	R:R:L309	R:R:L341	2.77	No	No	0	9	9
377	R:R:L309	R:R:L345	2.77	No	Yes	0	9	9
378	R:R:T338	R:R:V313	4.76	No	No	0	9	6
379	R:R:K319	R:R:V315	3.04	No	No	0	9	8
380	R:R:I317	R:R:T318	3.04	No	No	0	5	7
381	R:R:V335	R:R:Y331	8.83	No	No	0	8	7
382	R:R:M332	R:R:R336	3.72	No	No	0	6	8
383	R:R:K333	R:R:R336	8.66	No	No	0	8	8
384	R:R:I340	R:R:R336	7.52	No	No	0	8	8
385	R:R:P343	R:R:V342	3.53	No	No	0	9	8
386	R:R:L379	R:R:P343	3.28	No	No	0	5	9
387	R:R:L344	R:R:L345	2.77	No	Yes	0	9	9
388	R:R:F384	R:R:L344	10.96	Yes	No	0	8	9
389	R:R:I347	R:R:L345	2.85	No	Yes	0	7	9
390	R:R:E348	R:R:G346	3.27	Yes	No	1	8	9
391	R:R:G346	R:R:Q376	3.29	No	Yes	1	9	9
392	R:R:E348	R:R:F349	7	Yes	Yes	1	8	8
393	R:R:E348	R:R:L372	5.3	Yes	No	0	8	6
394	R:R:E348	R:R:Q376	11.47	Yes	Yes	1	8	9
395	R:R:F349	R:R:M373	11.2	Yes	No	1	8	7
396	R:R:E363	R:R:V364	5.7	No	No	0	4	4
397	R:R:M369	R:R:M373	5.78	No	No	1	8	7
398	R:R:H370	R:R:H374	14.33	Yes	No	1	7	9
399	R:R:F375	R:R:I371	7.54	No	No	0	7	6
400	R:R:L378	R:R:T382	2.95	No	No	0	6	5
401	R:R:F384	R:R:V380	5.24	Yes	No	0	8	9
402	R:R:F386	R:R:T382	5.19	Yes	No	0	8	5
403	R:R:F387	R:R:T382	6.49	No	No	0	5	5
404	R:R:F384	R:R:I383	7.54	Yes	No	0	8	7
405	R:R:C385	R:R:F386	4.19	Yes	Yes	1	9	8
406	R:R:E390	R:R:N388	9.2	No	No	1	9	9
407	R:R:N388	R:R:V391	7.39	No	No	0	9	9
408	R:R:L395	R:R:V391	2.98	No	No	0	5	9
409	R:R:I394	R:R:R397	6.26	No	No	0	8	7
410	E:E:L34	E:E:M33	11.31	No	Yes	10	5	8
411	E:E:M33	E:E:V80	13.69	Yes	No	0	8	5
412	E:E:L88	E:E:M33	5.65	No	Yes	10	6	8
413	E:E:L34	E:E:L88	17.99	No	No	10	5	6
414	E:E:F92	E:E:L34	8.53	No	No	0	8	5
415	E:E:E76	E:E:R36	13.96	No	No	0	6	3
416	E:E:L37	E:E:T73	4.42	No	No	0	8	9
417	E:E:F92	E:E:L37	10.96	No	No	0	8	8
418	E:E:F92	E:E:P38	2.89	No	No	0	8	5
419	E:E:C40	E:E:C72	7.28	No	No	0	9	9
420	E:E:F44	E:E:Y65	3.09	No	No	0	9	5
421	E:E:F44	E:E:Y66	5.16	No	No	0	9	9
422	E:E:F44	E:E:F69	6.43	No	Yes	0	9	8
423	E:E:K50	E:E:M47	2.88	No	No	0	3	4
424	E:E:M48	E:E:W56	3.49	No	No	0	9	7
425	E:E:F100	E:E:M48	6.22	No	No	0	8	9
426	E:E:K50	E:E:Y65	17.91	No	No	0	3	5
427	E:E:E61	E:E:V51	11.41	No	No	0	6	6
428	E:E:D52	E:E:W54	3.35	No	No	0	6	3
429	E:E:D52	E:E:K55	8.3	No	No	0	6	4
430	E:E:V53	E:E:W56	4.9	No	No	0	4	7
431	E:E:K55	E:E:N58	8.39	No	No	0	4	8
432	E:E:F101	E:E:W56	15.03	No	No	0	9	7
433	E:E:C104	E:E:C57	7.28	No	No	0	9	9
434	E:E:E61	E:E:N58	15.77	No	No	0	6	8
435	E:E:I63	E:E:L59	7.14	No	No	0	6	7
436	E:E:H97	E:E:Y66	7.62	No	No	0	9	9
437	E:E:F69	E:E:T73	5.19	Yes	No	0	8	9
438	E:E:F69	E:E:I96	6.28	Yes	No	0	8	6
439	E:E:T70	E:E:W84	4.85	No	Yes	0	9	9
440	E:E:E74	E:E:N71	5.26	No	No	0	5	4
441	E:E:E74	E:E:W84	14.17	No	Yes	0	5	9
442	E:E:A77	E:E:N78	3.13	No	No	0	7	1
443	E:E:C82	E:E:N86	11.02	No	No	0	9	9
444	E:E:P85	E:E:W84	5.4	No	Yes	2	9	9
445	E:E:N86	E:E:P87	4.89	No	No	0	9	5
446	E:E:G91	E:E:Q90	3.29	No	No	0	4	9
447	E:E:G95	E:E:T94	3.64	No	No	0	3	7
448	E:E:I96	E:E:Q99	5.49	No	No	0	6	4
449	E:E:F100	E:E:Q99	9.37	No	No	0	8	4
450	E:E:F100	E:E:F101	20.36	No	No	0	8	9
451	E:E:L111	E:E:V109	4.47	No	No	0	4	5
452	E:E:E112	E:E:H110	22.16	No	No	0	4	4
453	E:E:D113	E:E:P114	4.83	No	Yes	0	9	9
454	E:E:L119	E:E:P114	8.21	Yes	Yes	0	9	9
455	E:E:I123	E:E:L119	5.71	No	Yes	0	9	9
456	E:E:I120	E:E:P121	5.08	No	No	0	5	5
457	E:E:I125	E:E:P126	3.39	No	No	0	5	9
458	E:E:I125	E:E:L129	2.85	No	No	0	5	7
459	E:E:R143	E:E:W139	18.99	No	No	0	8	9
460	E:E:K142	E:E:R143	4.95	No	No	0	8	8
461	R:R:E83	R:R:I104	2.73	No	No	0	3	4
462	L:L:K36	R:R:Q93	2.71	No	No	0	0	4
463	E:E:C57	R:R:Y46	2.69	No	Yes	0	9	2
464	R:R:A44	R:R:Y91	2.67	No	Yes	0	6	5
465	E:E:Q90	R:R:N66	2.64	No	No	0	9	5
466	E:E:E74	E:E:N78	2.63	No	No	0	5	1
467	R:R:A271	R:R:W283	2.59	No	Yes	0	5	8
468	E:E:V64	E:E:Y65	2.52	No	No	0	4	5
469	L:L:I47	L:L:R44	2.51	No	No	0	0	0
470	E:E:F69	E:E:I93	2.51	Yes	No	0	8	9
471	R:R:T239	R:R:Y236	2.5	No	Yes	1	7	8
472	R:R:T239	R:R:Y255	2.5	No	Yes	1	7	8
473	R:R:N311	R:R:R314	2.41	No	No	0	7	7
474	R:R:L276	R:R:Y277	2.34	No	No	0	3	3
475	R:R:Q392	R:R:R396	2.34	No	No	0	7	5
476	R:R:N66	R:R:Y64	2.33	No	No	0	5	3
477	E:E:Q90	R:R:Y49	2.25	No	No	0	9	3
478	R:R:G261	R:R:P263	2.03	No	Yes	0	7	9
479	R:R:R396	R:R:W399	2	No	No	0	5	5
480	R:R:A80	R:R:G81	1.95	No	No	0	6	7
481	E:E:P114	E:E:P115	1.95	Yes	No	9	9	8
482	E:E:A134	E:E:G135	1.95	No	No	0	8	7
483	L:L:G51	L:L:S45	1.86	No	No	0	0	0
484	L:L:G51	L:L:S48	1.86	No	No	0	0	0
485	E:E:V127	R:R:G296	1.84	No	No	0	7	4
486	E:E:G135	E:E:V138	1.84	No	No	0	7	9
487	R:R:G81	R:R:T82	1.82	No	No	0	7	5
488	E:E:G91	E:E:T94	1.82	No	No	0	4	7
489	E:E:A77	E:E:C82	1.81	No	No	0	7	9
490	R:R:P343	R:R:V380	1.77	No	No	0	9	9
491	E:E:P114	E:E:V118	1.77	Yes	No	9	9	7
492	E:E:P115	E:E:V118	1.77	No	No	9	8	7
493	R:R:G148	R:R:I147	1.76	No	No	0	9	5
494	E:E:G41	E:E:I96	1.76	No	No	0	7	6
495	R:R:P209	R:R:T207	1.75	No	No	0	5	3
496	E:E:G49	E:E:M48	1.75	No	No	0	3	9
497	R:R:G161	R:R:L160	1.71	No	No	0	1	5
498	R:R:G234	R:R:L237	1.71	No	No	0	8	9
499	E:E:V127	R:R:A300	1.7	No	No	0	7	3
500	E:E:V131	R:R:A300	1.7	No	No	0	6	3
501	E:E:K42	E:E:P38	1.67	No	No	0	3	5
502	R:R:A334	R:R:I317	1.62	No	No	0	8	5
503	E:E:A89	E:E:I93	1.62	No	No	0	8	9
504	E:E:A43	E:E:M47	1.61	No	No	0	2	4
505	E:E:V79	E:E:V80	1.6	No	No	0	1	5
506	R:R:T323	R:R:V322	1.59	No	No	0	5	6
507	R:R:T338	R:R:V342	1.59	No	No	0	9	8
508	R:R:A337	R:R:L316	1.58	No	No	0	9	8
509	R:R:A334	R:R:L330	1.58	No	No	0	8	6
510	R:R:I347	R:R:V350	1.54	No	No	0	7	6
511	L:L:Q29	R:R:A138	1.52	No	No	0	0	5
512	R:R:I192	R:R:T196	1.52	No	No	0	6	3
513	E:E:C40	E:E:E76	1.52	No	No	0	9	6
514	L:L:F18	L:L:G19	1.51	No	No	0	0	0
515	L:L:K38	R:R:T37	1.5	No	No	0	0	4
516	E:E:G95	E:E:R98	1.5	No	No	0	3	6
517	R:R:L139	R:R:V135	1.49	No	No	0	3	1
518	R:R:L303	R:R:V350	1.49	No	No	0	3	6
519	E:E:N58	E:E:S60	1.49	No	No	0	8	7
520	R:R:N39	R:R:V36	1.48	No	No	0	5	2
521	R:R:I146	R:R:I147	1.47	No	No	0	6	5
522	R:R:I340	R:R:I383	1.47	No	No	0	8	7
523	L:L:Q29	R:R:S98	1.44	No	No	0	0	3
524	R:R:K100	R:R:M85	1.44	No	No	0	3	4
525	R:R:I147	R:R:L151	1.43	No	No	0	5	5
526	R:R:I368	R:R:L372	1.43	No	No	0	4	6
527	R:R:K333	R:R:L320	1.41	No	No	0	8	7
528	R:R:K321	R:R:L330	1.41	No	No	0	6	6
529	L:L:C16	L:L:F18	1.4	No	No	0	0	0
530	R:R:K134	R:R:N130	1.4	No	No	0	3	2
531	R:R:M332	R:R:N329	1.4	No	No	0	6	5
532	E:E:C40	E:E:F69	1.4	No	Yes	0	9	8
533	R:R:D366	R:R:M369	1.39	No	No	0	6	8
534	R:R:L306	R:R:L310	1.38	No	No	0	5	5
535	R:R:L309	R:R:L310	1.38	No	No	0	9	5
536	R:R:L316	R:R:L320	1.38	No	No	0	8	7
537	L:L:D39	L:L:N40	1.35	No	No	0	0	0
538	E:E:E35	E:E:M33	1.35	No	Yes	0	3	8
539	E:E:E61	E:E:K50	1.35	No	No	0	6	3
540	R:R:N398	R:R:Q401	1.32	No	No	0	5	6
541	E:E:R98	E:E:S102	1.32	No	No	0	6	7
542	R:R:R314	R:R:T318	1.29	No	No	0	7	7
543	R:R:N118	R:R:R119	1.21	No	No	0	6	4
544	R:R:F166	R:R:N398	1.21	Yes	No	0	7	5
545	E:E:D107	E:E:R108	1.19	No	No	0	5	4
546	R:R:N329	R:R:Y331	1.16	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:T22	3.9675	4	1	0
2	L:L:I30	5.008	5	4	0
3	L:L:F33	6.17	5	5	0
4	L:L:K46	6.9525	4	2	0
5	L:L:Y52	8.432	5	2	0
6	R:R:Y46	10.474	5	7	2
7	R:R:W69	6.882	5	2	7
8	R:R:D70	8.3175	4	2	9
9	R:R:G71	5.1575	4	2	4
10	R:R:W72	6.60857	7	2	5
11	R:R:W75	9.14833	6	2	9
12	R:R:C88	5.7125	4	2	9
13	R:R:Y91	7.835	6	2	5
14	R:R:F92	6.91333	6	2	6
15	R:R:F95	5.66	6	2	5
16	R:R:K103	10.97	5	2	8
17	R:R:W111	8.83143	7	2	9
18	R:R:H114	10.412	5	0	4
19	R:R:Y124	7.30286	7	2	4
20	R:R:H149	8.8825	4	0	7
21	R:R:I153	3.9075	4	0	6
22	R:R:L156	5.802	5	1	9
23	R:R:S159	5.585	4	1	8
24	R:R:F166	4.836	5	1	7
25	R:R:Q172	7.495	4	1	7
26	R:R:R173	4.12	6	1	9
27	R:R:I174	4.18	5	1	9
28	R:R:L176	4.656	5	1	9
29	R:R:F181	5.278	5	1	8
30	R:R:F184	9.12667	6	1	8
31	R:R:Q216	7.7375	4	3	6
32	R:R:H219	5.0675	4	0	6
33	R:R:L220	7.514	5	3	7
34	R:R:Y221	7.7925	4	1	8
35	R:R:L222	3.456	5	1	5
36	R:R:C225	6.3325	4	1	8
37	R:R:Y227	8.08	4	1	8
38	R:R:F228	4.728	5	1	5
39	R:R:W229	9.16572	7	1	9
40	R:R:M230	5.1825	4	1	9
41	R:R:L231	4.44	4	0	8
42	R:R:E233	7.41	4	0	9
43	R:R:I235	4.956	5	1	6
44	R:R:Y236	6.62286	7	1	8
45	R:R:H238	10.7675	4	0	8
46	R:R:Q250	6.868	5	1	6
47	R:R:L252	5.2775	4	1	6
48	R:R:Y255	4.66	8	1	8
49	R:R:L258	3.855	4	0	6
50	R:R:W260	8.394	5	1	9
51	R:R:P263	4.136	5	1	9
52	R:R:H270	5.912	5	3	8
53	R:R:R274	12.4075	4	3	7
54	R:R:Y278	8.52	4	3	6
55	R:R:D280	6.724	5	3	4
56	R:R:W283	10.7583	6	3	8
57	R:R:L290	3.662	5	0	3
58	R:R:Y292	8.99	4	0	6
59	R:R:I293	3.155	4	3	8
60	R:R:P297	4	5	1	8
61	R:R:F308	9.5625	4	0	8
62	R:R:L345	5.53	4	0	9
63	R:R:E348	6.76	4	1	8
64	R:R:F349	8.012	5	1	8
65	R:R:H370	9.5575	4	1	7
66	R:R:Q376	8.61	4	1	9
67	R:R:S381	5.675	4	1	8
68	R:R:F384	7.0675	4	0	8
69	R:R:C385	4.985	4	1	9
70	R:R:F386	4.6075	4	1	8
71	E:E:M33	8	4	10	8
72	E:E:F69	4.362	5	0	8
73	E:E:W84	6.77167	6	2	9
74	E:E:V106	6.925	4	0	4
75	E:E:P114	3.908	5	9	9
76	E:E:L119	5.1375	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C21	L:L:K25	25.2259	3.23	No	No	0	0	0
2	L:L:K25	L:L:T22	77.5203	3	No	Yes	0	0	0
3	L:L:T22	R:R:M373	67.7406	3.01	Yes	No	1	0	7
4	R:R:F349	R:R:M373	67.8754	11.2	Yes	No	1	8	7
5	R:R:F349	R:R:Y227	33.5276	9.28	Yes	Yes	1	8	8
6	L:L:C21	R:R:H295	18.5582	13.27	No	No	0	0	6
7	L:L:T22	R:R:H370	10.4177	6.85	Yes	Yes	1	0	7
8	R:R:H295	R:R:L291	18.4587	3.86	No	No	0	6	5
9	R:R:H219	R:R:L220	11.4176	5.14	Yes	Yes	0	6	7
10	R:R:H270	R:R:L291	11.6441	3.86	Yes	No	0	8	5
11	L:L:K25	R:R:S286	100	3.06	No	No	0	0	7
12	L:L:H28	R:R:S286	99.9947	9.76	No	No	0	0	7
13	L:L:H28	L:L:Q32	99.9826	21.02	No	No	0	0	0
14	L:L:F33	L:L:Q32	99.8099	7.03	Yes	No	5	0	0
15	L:L:F33	R:R:D96	99.902	9.55	Yes	No	0	0	5
16	R:R:D96	R:R:T131	99.8525	13.01	No	No	0	5	1
17	R:R:D94	R:R:T131	99.8388	2.89	No	No	0	5	1
18	L:L:A42	R:R:D94	99.7788	3.09	No	No	0	0	5
19	L:L:A42	R:R:F92	50.1346	2.77	No	Yes	2	0	6
20	L:L:A42	R:R:F95	49.6277	2.77	No	Yes	2	0	5
21	R:R:F92	R:R:W72	47.6606	3.01	Yes	Yes	2	6	5
22	L:L:Y52	R:R:W72	87.0172	12.54	Yes	Yes	2	0	5
23	R:R:F95	R:R:W72	47.3472	4.01	Yes	Yes	2	5	5
24	L:L:Y52	R:R:G71	27.9806	4.35	Yes	Yes	2	0	4
25	E:E:W84	L:L:Y52	52.2836	9.65	Yes	Yes	2	9	0
26	R:R:G71	R:R:W69	28.1778	8.44	Yes	Yes	2	4	7
27	R:R:Q45	R:R:W69	43.9975	13.14	No	Yes	0	5	7
28	E:E:Y66	R:R:Q45	64.6534	11.27	No	No	0	9	5
29	E:E:H97	E:E:Y66	18.4945	7.62	No	No	0	9	9
30	E:E:W84	R:R:W69	27.727	3.75	Yes	Yes	2	9	7
31	E:E:T70	E:E:W84	22.0557	4.85	No	Yes	0	9	9
32	E:E:T70	R:R:Q45	21.706	4.25	No	No	0	9	5
33	R:R:W69	R:R:Y49	10.2853	3.86	Yes	No	0	7	3
34	R:R:M230	R:R:Y227	33.4754	5.99	Yes	Yes	1	9	8
35	R:R:F184	R:R:M230	33.1094	3.73	Yes	Yes	1	8	9
36	R:R:E348	R:R:F349	33.6937	7	Yes	Yes	1	8	8
37	R:R:E348	R:R:Q376	33.2313	11.47	Yes	Yes	1	8	9
38	R:R:F184	R:R:Q376	33.1616	12.88	Yes	Yes	1	8	9
39	R:R:F184	R:R:L156	16.1477	6.09	Yes	Yes	1	8	9
40	R:R:F184	R:R:L180	53.7911	6.09	Yes	No	0	8	9
41	R:R:F181	R:R:S159	12.6629	5.28	Yes	Yes	1	8	8
42	R:R:C385	R:R:S159	13.2972	6.89	Yes	Yes	1	9	8
43	R:R:E233	R:R:L180	46.9986	3.98	Yes	No	0	9	9
44	R:R:E233	R:R:H177	12.1633	11.08	Yes	No	0	9	9
45	R:R:E233	R:R:L176	23.5449	3.98	Yes	Yes	0	9	9
46	R:R:L176	R:R:Y255	14.8272	3.52	Yes	Yes	1	9	8
47	R:R:H219	R:R:V190	11.341	4.15	Yes	No	0	6	6
48	R:R:L222	R:R:V190	10.8783	2.98	Yes	No	0	5	6
49	R:R:E233	R:R:L344	13.4241	10.6	Yes	No	0	9	9
50	R:R:I235	R:R:Y255	10.3258	4.84	Yes	Yes	1	6	8
51	E:E:L37	E:E:T73	10.912	4.42	No	No	0	8	9
52	E:E:F69	E:E:T73	12.0003	5.19	Yes	No	0	8	9
53	E:E:F44	E:E:F69	31.5002	6.43	No	Yes	0	9	8
54	E:E:F44	E:E:Y66	45.4774	5.16	No	No	0	9	9
55	E:E:F44	E:E:Y65	13.0881	3.09	No	No	0	9	5
56	E:E:K50	E:E:Y65	10.912	17.91	No	No	0	3	5
57	E:E:F69	E:E:I96	12.0003	6.28	Yes	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C16	R:R:Y292	9.41	0	No	Yes	0	6	0	1
L:L:R17	R:R:Y292	3.09	0	No	Yes	0	6	0	1
L:L:F18	R:R:C299	2.79	0	No	No	0	4	0	1
L:L:T20	R:R:Y227	3.75	1	No	Yes	0	8	0	1
L:L:T20	R:R:I298	4.56	1	No	No	0	7	0	1
L:L:T20	R:R:F349	6.49	1	No	Yes	0	8	0	1
L:L:C21	R:R:H295	13.27	0	No	No	0	6	0	1
L:L:T22	R:R:M369	3.01	1	Yes	No	0	8	0	1
L:L:T22	R:R:H370	6.85	1	Yes	Yes	0	7	0	1
L:L:T22	R:R:M373	3.01	1	Yes	No	0	7	0	1
L:L:V23	R:R:H219	2.77	0	No	Yes	0	6	0	1
L:L:Q24	R:R:Q216	5.12	3	No	Yes	0	6	0	1
L:L:Q24	R:R:L220	5.32	3	No	Yes	0	7	0	1
L:L:Q24	R:R:L291	7.99	3	No	No	0	5	0	1
L:L:K25	R:R:S286	3.06	0	No	No	0	7	0	1
L:L:L26	R:R:T145	2.95	0	No	No	0	7	0	1
L:L:A27	R:R:I284	3.25	0	No	No	0	6	0	1
L:L:H28	R:R:S286	9.76	0	No	No	0	7	0	1
L:L:H28	R:R:D287	8.82	0	No	No	0	3	0	1
L:L:I30	R:R:F142	8.79	4	Yes	No	0	6	0	1
L:L:I30	R:R:A199	3.25	4	Yes	No	0	4	0	1
L:L:I30	R:R:N200	4.25	4	Yes	No	0	3	0	1
L:L:Y31	R:R:Q202	6.76	0	No	No	0	2	0	1
L:L:Y31	R:R:V205	10.09	0	No	No	0	4	0	1
L:L:Y31	R:R:I284	10.88	0	No	No	0	6	0	1
L:L:Q32	R:R:P97	20.53	5	No	No	0	3	0	1
L:L:F33	R:R:D96	9.55	5	Yes	No	0	5	0	1
L:L:F33	R:R:P97	2.89	5	Yes	No	0	3	0	1
L:L:F33	R:R:V135	7.87	5	Yes	No	0	1	0	1
L:L:T34	R:R:N200	4.39	4	No	No	0	3	0	1
L:L:T34	R:R:Q202	5.67	4	No	No	0	2	0	1
L:L:D35	R:R:Q202	9.14	0	No	No	0	2	0	1
L:L:K38	R:R:Q93	5.42	0	No	No	0	4	0	1
L:L:V41	R:R:D94	2.92	0	No	No	0	5	0	1
L:L:A42	R:R:F92	2.77	2	No	Yes	0	6	0	1
L:L:A42	R:R:D94	3.09	2	No	No	0	5	0	1
L:L:A42	R:R:F95	2.77	2	No	Yes	0	5	0	1
L:L:P43	R:R:F92	14.45	0	No	Yes	0	6	0	1
L:L:K46	R:R:W72	4.64	2	Yes	Yes	0	5	0	1
L:L:K46	R:R:Y124	5.97	2	Yes	Yes	0	4	0	1
L:L:K46	R:R:T125	6.01	2	Yes	No	0	6	0	1
L:L:K46	R:R:N128	11.19	2	Yes	No	0	3	0	1
L:L:P49	R:R:H114	6.1	6	No	Yes	0	4	0	1
E:E:Y83	L:L:Q50	3.38	0	No	No	6	0	1	0
L:L:Y52	R:R:G71	4.35	2	Yes	Yes	0	4	0	1
L:L:Y52	R:R:W72	12.54	2	Yes	Yes	0	5	0	1
E:E:W84	L:L:Y52	9.65	2	Yes	Yes	9	0	1	0
E:E:P85	L:L:Y52	4.17	2	No	Yes	9	0	1	0
R:R:F92	R:R:T37	6.49	2	Yes	No	6	4	1	1
R:R:I41	R:R:W72	4.7	2	No	Yes	6	5	2	1
R:R:I41	R:R:Y91	13.3	2	No	Yes	6	5	2	2
R:R:G71	R:R:W69	8.44	2	Yes	Yes	4	7	1	2
E:E:W84	R:R:W69	3.75	2	Yes	Yes	9	7	1	2
R:R:D70	R:R:G71	5.03	2	Yes	Yes	9	4	2	1
R:R:D70	R:R:L73	6.79	2	Yes	No	9	5	2	2
R:R:D70	R:R:W75	13.4	2	Yes	Yes	9	9	2	2
R:R:D70	R:R:Y124	8.05	2	Yes	Yes	9	4	2	1
E:E:W84	R:R:G71	2.81	2	Yes	Yes	9	4	1	1
R:R:W72	R:R:Y91	6.75	2	Yes	Yes	5	5	1	2
R:R:F92	R:R:W72	3.01	2	Yes	Yes	6	5	1	1
R:R:F95	R:R:W72	4.01	2	Yes	Yes	5	5	1	1
R:R:W72	R:R:Y124	10.61	2	Yes	Yes	5	4	1	1
R:R:L73	R:R:Y124	3.52	2	No	Yes	5	4	2	1
R:R:T122	R:R:W75	3.64	2	No	Yes	7	9	2	2
R:R:W75	R:R:Y124	2.89	2	Yes	Yes	9	4	2	1
R:R:C88	R:R:F95	8.38	2	Yes	Yes	9	5	2	1
R:R:C88	R:R:V101	3.42	2	Yes	No	9	7	2	2
R:R:C127	R:R:C88	7.28	2	No	Yes	9	9	2	2
R:R:F92	R:R:Y91	6.19	2	Yes	Yes	6	5	1	2
R:R:F92	R:R:F95	8.57	2	Yes	Yes	6	5	1	1
R:R:D94	R:R:T131	2.89	0	No	No	5	1	1	2
R:R:C127	R:R:F95	4.19	2	No	Yes	9	5	2	1
R:R:F95	R:R:N128	6.04	2	Yes	No	5	3	1	1
R:R:D96	R:R:T131	13.01	0	No	No	5	1	1	2
R:R:D96	R:R:K134	4.15	0	No	No	5	3	1	2
R:R:V101	R:R:Y124	10.09	0	No	Yes	7	4	2	1
R:R:F112	R:R:H114	4.53	0	No	Yes	5	4	2	1
R:R:H114	R:R:P115	7.63	0	Yes	No	4	3	1	2
R:R:H114	R:R:S117	4.18	0	Yes	No	4	4	1	2
R:R:H114	R:R:W121	29.62	0	Yes	No	4	8	1	2
E:E:Y83	R:R:S117	5.09	0	No	No	6	4	1	2
E:E:Y83	R:R:R119	10.29	0	No	No	6	4	1	2
R:R:T122	R:R:Y124	9.99	2	No	Yes	7	4	2	1
R:R:H370	R:R:L141	11.57	1	Yes	No	7	6	1	2
R:R:F142	R:R:I146	3.77	0	No	No	6	6	1	2
R:R:F142	R:R:L195	7.31	0	No	No	6	7	1	2
R:R:H370	R:R:T145	5.48	1	Yes	No	7	7	1	1
R:R:H374	R:R:T145	19.17	1	No	No	9	7	2	1
R:R:H219	R:R:V190	4.15	0	Yes	No	6	6	1	2
R:R:H219	R:R:T191	8.21	0	Yes	No	6	7	1	2
R:R:H194	R:R:Q216	6.18	0	No	Yes	7	6	2	1
R:R:C282	R:R:V205	10.25	0	No	No	9	4	2	1
R:R:L220	R:R:Q216	11.98	3	Yes	Yes	7	6	1	1
R:R:Q216	R:R:W283	7.67	3	Yes	Yes	6	8	1	2
R:R:H219	R:R:L220	5.14	0	Yes	Yes	6	7	1	1
R:R:H270	R:R:L220	5.14	3	Yes	Yes	8	7	2	1
R:R:I294	R:R:L220	9.99	3	No	Yes	7	7	2	1
R:R:M230	R:R:Y227	5.99	1	Yes	Yes	9	8	2	1
R:R:I298	R:R:Y227	13.3	1	No	Yes	7	8	1	1
R:R:F349	R:R:Y227	9.28	1	Yes	Yes	8	8	1	1
R:R:H270	R:R:L291	3.86	3	Yes	No	8	5	2	1
R:R:H270	R:R:I294	5.3	3	Yes	No	8	7	2	2
R:R:H289	R:R:Y292	17.42	0	No	Yes	4	6	2	1
R:R:H295	R:R:L291	3.86	0	No	No	6	5	1	1
E:E:I123	R:R:Y292	6.04	0	No	Yes	9	6	2	1
R:R:I298	R:R:L302	2.85	1	No	No	7	7	1	2
R:R:F349	R:R:L302	6.09	1	Yes	No	8	7	1	2
R:R:E348	R:R:F349	7	1	Yes	Yes	8	8	2	1
R:R:F349	R:R:M373	11.2	1	Yes	No	8	7	1	1
R:R:M369	R:R:M373	5.78	1	No	No	8	7	1	1
R:R:H370	R:R:H374	14.33	1	Yes	No	7	9	1	2
E:E:T70	E:E:W84	4.85	0	No	Yes	9	9	2	1
E:E:E74	E:E:W84	14.17	0	No	Yes	5	9	2	1
E:E:P85	E:E:W84	5.4	2	No	Yes	9	9	1	1
L:L:K36	R:R:Q93	2.71	0	No	No	0	4	0	1
L:L:Q29	R:R:A138	1.52	0	No	No	0	5	0	1
L:L:K38	R:R:T37	1.5	0	No	No	0	4	0	1
R:R:L139	R:R:V135	1.49	0	No	No	3	1	2	1
L:L:Q29	R:R:S98	1.44	0	No	No	0	3	0	1
R:R:D366	R:R:M369	1.39	0	No	No	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6UUS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	454
Number of Links	546
Number of Hubs	76
Number of Links mediated by Hubs	283
Number of Communities	10
Number of Nodes involved in Communities	120
Number of Links involved in Communities	174

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	486659
Length Of Smallest Path	3
Average Path Length	25.466
Length of Longest Path	45
Minimum Path Strength	1.265
Average Path Strength	7.00158
Maximum Path Strength	22.44
Minimum Path Correlation	0.7
Average Path Correlation	0.961244
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	46.1555
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.312
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • adrenomedullin receptor binding • G protein-coupled receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • regulation of body fluid levels • renal system process • regulation of urine volume • regulation of biological quality • heart process • regulation of heart contraction • regulation of system process • positive regulation of biological process • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • positive regulation of multicellular organismal process • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of heart rate • heart development • circulatory system development • regulation of tube diameter • regulation of tube size • negative regulation of biological process • negative regulation of vasoconstriction • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • negative regulation of multicellular organismal process • vasoconstriction • regulation of anatomical structure size • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of developmental process • cellular developmental process • regulation of vasculogenesis • regulation of cell differentiation • vasculogenesis • positive regulation of developmental process • tube morphogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of cellular process • blood vessel development • blood vessel morphogenesis • tube development • vasculature development • anatomical structure morphogenesis • positive regulation of vasculogenesis • smooth muscle cell differentiation • cell development • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • chordate embryonic development • labyrinthine layer development • embryo development • embryonic placenta development • embryo development ending in birth or egg hatching • embryonic organ development • epithelium development • placenta development • embryonic morphogenesis • morphogenesis of an epithelium • branching involved in labyrinthine layer morphogenesis • tissue development • in utero embryonic development • embryonic placenta morphogenesis • labyrinthine layer morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • morphogenesis of a branching epithelium • developmental growth • growth • negative regulation of vascular permeability • regulation of vascular permeability • embryonic epithelial tube formation • tube formation • epithelial tube formation • primary neural tube formation • epithelial tube morphogenesis • morphogenesis of embryonic epithelium • neural tube development • nervous system development • neural tube closure • neural tube formation • anatomical structure formation involved in morphogenesis • tube closure • positive regulation of cell population proliferation • regulation of cell population proliferation • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • angiogenesis • regulation of vasculature development • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of progesterone biosynthetic process • regulation of hormone biosynthetic process • regulation of lipid metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • hormone biosynthetic process • olefinic compound biosynthetic process • regulation of hormone levels • C21-steroid hormone biosynthetic process • regulation of progesterone biosynthetic process • primary metabolic process • regulation of ketone metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • metabolic process • positive regulation of hormone biosynthetic process • regulation of metabolic process • regulation of steroid biosynthetic process • ketone metabolic process • regulation of hormone metabolic process • steroid metabolic process • lipid biosynthetic process • C21-steroid hormone metabolic process • positive regulation of biosynthetic process • progesterone metabolic process • steroid biosynthetic process • steroid hormone biosynthetic process • regulation of biosynthetic process • small molecule biosynthetic process • positive regulation of hormone metabolic process • progesterone biosynthetic process • regulation of ketone biosynthetic process • regulation of steroid metabolic process • hormone metabolic process • positive regulation of lipid biosynthetic process • positive regulation of steroid metabolic process • olefinic compound metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • ketone biosynthetic process • lipid metabolic process • regulation of systemic arterial blood pressure • regulation of blood pressure • defense response • response to stress • inflammatory response • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • vesicle lumen • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • cytoplasmic vesicle • organelle lumen • secretory granule • secretory vesicle • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • calcitonin family binding • amide binding • adrenomedullin binding • peptide hormone binding • hormone binding • adrenomedullin receptor activity • calcitonin gene-related peptide receptor activity • establishment of protein localization • nitrogen compound transport • protein transport • macromolecule localization • intracellular protein localization • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • response to disaccharide • cellular response to sucrose stimulus • cellular response to carbohydrate stimulus • response to carbohydrate • response to sucrose • cellular response to disaccharide stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • endosome • CGRP receptor complex • endoplasmic reticulum • amyloid-beta binding • peptide binding • coreceptor activity • amylin receptor activity • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of intracellular signal transduction • calcium-mediated signaling • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • positive regulation of protein localization to plasma membrane • regulation of localization • cellular localization • regulation of protein localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • regulation of signaling receptor activity • negative regulation of molecular function • regulation of molecular function • cross-receptor inhibition within G protein-coupled receptor heterodimer • negative regulation of signaling receptor activity • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of receptor recycling • receptor recycling • receptor metabolic process • positive regulation of receptor recycling • response to amyloid-beta • G protein-coupled receptor signaling pathway involved in heart process • intracellular transport • establishment of localization in cell • intracellular protein transport • amylin receptor signaling pathway • response to estradiol • cellular response to estradiol stimulus • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • cell surface • amylin receptor complex • amylin receptor complex 3
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16602
Sequence	>6UUS_nogp_Chain_R G V T R N K I M T A Q Y E C Y Q K I M Q Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D N W F R H P A S N R T W T N Y T Q C N V N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F K S L S C Q R I T L H K N L F F S F V C N S V V T I I H L T A V A N N Q A L V A T N P V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V A V F A E K Q H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y N D N C W I S S D T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K V T N L Y M K A V R A T L I L V P L L G I E F V L E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E V Q A I L R R N W N Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>6UUS_nogp_Chain_E M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080

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