psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:L34	E:E:R36	3.64	No	Yes	0	5	3
2	E:E:L34	E:E:N86	4.12	No	No	0	5	9
3	E:E:E35	E:E:R36	4.65	No	Yes	0	3	3
4	E:E:E76	E:E:R36	11.63	No	Yes	0	6	3
5	E:E:F92	E:E:L37	6.09	No	No	0	8	8
6	E:E:C40	E:E:C72	7.28	No	No	0	9	9
7	E:E:F69	E:E:G41	4.52	Yes	No	8	8	7
8	E:E:G41	E:E:I96	3.53	No	No	8	7	6
9	E:E:K42	E:E:Q99	6.78	No	No	0	3	4
10	E:E:F44	E:E:M48	7.46	No	Yes	0	9	9
11	E:E:F44	E:E:F69	21.43	No	Yes	0	9	8
12	E:E:A45	E:E:F100	4.16	No	Yes	0	5	8
13	E:E:M47	E:E:Y65	7.18	No	No	0	4	5
14	E:E:M48	E:E:W56	6.98	Yes	Yes	7	9	7
15	E:E:F100	E:E:M48	4.98	Yes	Yes	7	8	9
16	E:E:F101	E:E:M48	4.98	Yes	Yes	7	9	9
17	E:E:K50	E:E:Y65	3.58	No	No	0	3	5
18	E:E:D52	E:E:K55	12.44	No	No	0	6	4
19	E:E:V53	E:E:W56	11.03	No	Yes	0	4	7
20	E:E:F100	E:E:W56	16.04	Yes	Yes	7	8	7
21	E:E:C104	E:E:C57	7.28	No	No	0	9	9
22	E:E:E61	E:E:N58	5.26	No	No	0	6	8
23	E:E:E61	E:E:S60	4.31	No	No	0	6	7
24	E:E:F62	E:E:I63	3.77	Yes	No	0	8	6
25	E:E:F62	E:E:Y66	4.13	Yes	No	0	8	9
26	E:E:F101	E:E:F62	7.5	Yes	Yes	0	9	8
27	E:E:F62	R:R:Y46	14.44	Yes	Yes	0	8	2
28	E:E:I63	R:R:M42	5.83	No	No	0	6	3
29	E:E:H97	E:E:Y66	4.36	No	No	0	9	9
30	E:E:Y66	R:R:Q45	6.76	No	No	0	9	5
31	E:E:E67	E:E:N71	5.26	No	No	0	4	4
32	E:E:E67	R:R:R38	4.65	No	No	0	4	5
33	E:E:E67	R:R:M42	4.06	No	No	0	4	3
34	E:E:F69	E:E:T73	6.49	Yes	No	0	8	9
35	E:E:F69	E:E:I93	5.02	Yes	No	0	8	9
36	E:E:F69	E:E:I96	3.77	Yes	No	8	8	6
37	E:E:E74	E:E:W84	37.07	No	No	0	5	9
38	E:E:A77	E:E:E76	4.53	No	No	0	7	6
39	E:E:A77	E:E:C82	3.61	No	No	0	7	9
40	E:E:P85	E:E:Y83	6.95	No	No	0	9	6
41	E:E:Y83	R:R:S117	10.17	No	No	0	6	4
42	E:E:Y83	R:R:R119	9.26	No	Yes	0	6	4
43	E:E:W84	L:L:Y47	16.4	No	No	0	9	0
44	E:E:A89	E:E:N86	4.69	No	No	0	8	9
45	E:E:G91	E:E:Q90	6.58	No	No	0	4	9
46	E:E:I93	R:R:Y49	9.67	No	No	0	9	3
47	E:E:F101	E:E:H97	26.02	Yes	No	0	9	9
48	E:E:H97	R:R:Y46	6.53	No	Yes	0	9	2
49	E:E:R98	E:E:S102	10.54	No	No	0	6	7
50	E:E:R98	R:R:M53	3.72	No	No	0	6	2
51	E:E:F100	E:E:Q99	7.03	Yes	No	0	8	4
52	E:E:F100	E:E:F101	6.43	Yes	Yes	7	8	9
53	E:E:D107	E:E:T105	5.78	No	No	0	5	8
54	E:E:R108	E:E:V106	3.92	No	No	0	4	4
55	E:E:R108	R:R:E47	10.47	No	No	0	4	6
56	E:E:E112	E:E:H110	8.62	No	No	0	4	4
57	E:E:L111	R:R:Y278	15.24	No	Yes	1	4	6
58	E:E:L111	R:R:D280	4.07	No	Yes	1	4	4
59	E:E:E112	R:R:Y277	5.61	No	No	0	4	3
60	E:E:D113	E:E:P114	4.83	No	Yes	0	9	9
61	E:E:L119	E:E:P114	18.06	No	Yes	0	9	9
62	E:E:P115	E:E:V118	5.3	No	No	0	8	7
63	E:E:I120	E:E:P121	6.77	No	No	0	5	5
64	E:E:L122	R:R:I269	4.28	No	No	1	9	5
65	E:E:L122	R:R:I293	4.28	No	No	1	9	8
66	E:E:I123	R:R:Y292	4.84	No	Yes	0	9	6
67	E:E:P126	R:R:P297	5.84	No	Yes	0	9	8
68	E:E:T130	R:R:F228	9.08	No	Yes	5	9	5
69	E:E:T130	R:R:F262	3.89	No	Yes	5	9	4
70	E:E:M133	R:R:F257	4.98	No	No	0	9	3
71	E:E:M133	R:R:L258	4.24	No	Yes	5	9	6
72	E:E:M133	R:R:F262	8.71	No	Yes	5	9	4
73	E:E:G135	E:E:V138	3.68	No	No	0	7	9
74	E:E:L136	R:R:W254	4.56	No	No	0	6	2
75	E:E:V137	R:R:I235	4.61	No	Yes	3	9	6
76	E:E:V137	R:R:Y255	5.05	No	Yes	3	9	8
77	E:E:R140	E:E:W139	5	No	No	0	8	9
78	E:E:R143	E:E:W139	23.99	No	No	0	8	9
79	E:E:R140	R:R:W254	17.99	No	No	0	8	2
80	E:E:S141	R:R:T239	7.99	No	No	3	9	7
81	E:E:S141	R:R:V245	6.46	No	Yes	3	9	7
82	E:E:S141	R:R:Q250	4.33	No	Yes	3	9	6
83	E:E:K142	E:E:R143	3.71	No	No	0	8	8
84	E:E:K142	R:R:V243	4.55	No	No	0	8	5
85	L:L:L6	L:L:R7	4.86	No	No	0	0	0
86	L:L:L6	R:R:Y292	4.69	No	Yes	0	0	6
87	L:L:R7	L:L:V11	5.23	No	No	0	0	0
88	L:L:C10	L:L:C15	7.28	No	No	2	0	0
89	L:L:C10	R:R:H295	4.42	No	Yes	2	0	6
90	L:L:V11	R:R:Y292	3.79	No	Yes	0	0	6
91	L:L:L12	R:R:Y292	3.52	No	Yes	0	0	6
92	L:L:T14	R:R:Y227	6.24	No	Yes	2	0	8
93	L:L:T14	R:R:H295	8.21	No	Yes	2	0	6
94	L:L:T14	R:R:I298	6.08	No	No	2	0	7
95	L:L:C15	R:R:H295	11.79	No	Yes	2	0	6
96	L:L:Q16	R:R:M369	6.8	No	Yes	0	0	8
97	L:L:Q16	R:R:H370	16.07	No	Yes	0	0	7
98	L:L:Q16	R:R:M373	4.08	No	No	0	0	7
99	L:L:V17	R:R:T191	4.76	No	Yes	0	0	7
100	L:L:Q18	R:R:Q216	6.4	Yes	Yes	1	0	6
101	L:L:Q18	R:R:H219	4.95	Yes	No	0	0	6
102	L:L:Q18	R:R:L220	3.99	Yes	Yes	1	0	7
103	L:L:Q18	R:R:L291	3.99	Yes	No	0	0	5
104	L:L:N19	R:R:S286	4.47	No	No	0	0	7
105	L:L:L20	R:R:H370	3.86	No	Yes	0	0	7
106	L:L:S21	R:R:L195	4.5	No	No	0	0	7
107	L:L:H22	L:L:Q26	22.25	No	No	0	0	0
108	L:L:H22	R:R:S285	4.18	No	Yes	0	0	5
109	L:L:H22	R:R:S286	8.37	No	No	0	0	7
110	L:L:Q26	L:L:R23	5.84	No	Yes	0	0	0
111	L:L:L27	L:L:R23	15.79	Yes	Yes	6	0	0
112	L:L:R23	R:R:D96	10.72	Yes	Yes	6	0	5
113	L:L:R23	R:R:S98	7.91	Yes	No	6	0	3
114	L:L:L24	R:R:F142	3.65	No	Yes	0	0	6
115	L:L:W25	R:R:I284	11.74	No	No	0	0	6
116	L:L:L27	R:R:D96	4.07	Yes	Yes	6	0	5
117	L:L:L27	R:R:V135	4.47	Yes	No	0	0	1
118	L:L:M28	R:R:L139	4.24	No	No	0	0	3
119	L:L:G29	L:L:P30	4.06	No	No	0	0	0
120	L:L:P30	L:L:R33	4.32	No	Yes	9	0	0
121	L:L:P30	R:R:D90	4.83	No	Yes	9	0	3
122	L:L:R33	R:R:T37	3.88	Yes	No	0	0	4
123	L:L:R33	R:R:D90	15.48	Yes	Yes	9	0	3
124	L:L:R33	R:R:Q93	23.36	Yes	No	0	0	4
125	L:L:Q34	R:R:T37	11.34	No	No	0	0	4
126	L:L:A37	L:L:P38	3.74	No	No	0	0	0
127	L:L:S43	L:L:V39	4.85	No	No	0	0	0
128	L:L:D40	L:L:S46	4.42	Yes	No	0	0	0
129	L:L:D40	R:R:F95	5.97	Yes	Yes	4	0	5
130	L:L:D40	R:R:Y124	4.6	Yes	Yes	4	0	4
131	L:L:D40	R:R:N128	8.08	Yes	No	4	0	3
132	L:L:P44	L:L:S43	5.34	No	No	0	0	0
133	L:L:H45	L:L:P44	7.63	No	No	0	0	0
134	L:L:P44	R:R:S117	3.56	No	No	0	0	4
135	L:L:S46	R:R:W121	6.18	No	No	0	0	8
136	L:L:Y47	R:R:W72	21.22	No	Yes	0	0	5
137	R:R:F92	R:R:T37	5.19	Yes	No	0	6	4
138	R:R:I41	R:R:R38	3.76	No	No	0	6	5
139	R:R:D90	R:R:K40	4.15	Yes	No	0	3	5
140	R:R:K40	R:R:Y91	7.17	No	Yes	0	5	5
141	R:R:I41	R:R:W72	3.52	No	Yes	0	6	5
142	R:R:Q45	R:R:W69	13.14	No	Yes	0	5	7
143	R:R:C48	R:R:W69	6.53	No	Yes	10	9	7
144	R:R:C48	R:R:C74	7.28	No	No	10	9	9
145	R:R:I52	R:R:K51	4.36	Yes	No	0	5	3
146	R:R:I52	R:R:R67	13.78	Yes	No	0	5	4
147	R:R:C105	R:R:C65	7.28	No	No	11	9	9
148	R:R:C65	R:R:W111	14.37	No	Yes	11	9	9
149	R:R:D77	R:R:R67	3.57	No	No	0	4	4
150	R:R:T68	R:R:W75	3.64	No	Yes	0	5	9
151	R:R:T68	R:R:W111	7.28	No	Yes	0	5	9
152	R:R:G71	R:R:W69	8.44	No	Yes	0	4	7
153	R:R:C74	R:R:W69	3.92	No	Yes	10	9	7
154	R:R:D70	R:R:W75	4.47	No	Yes	0	9	9
155	R:R:D70	R:R:T122	7.23	No	No	4	9	7
156	R:R:D70	R:R:Y124	5.75	No	Yes	4	9	4
157	R:R:W72	R:R:Y91	6.75	Yes	Yes	4	5	5
158	R:R:F92	R:R:W72	7.02	Yes	Yes	4	6	5
159	R:R:W72	R:R:Y124	17.36	Yes	Yes	4	5	4
160	R:R:L73	R:R:Q86	7.99	Yes	No	0	5	5
161	R:R:L73	R:R:P89	9.85	Yes	No	4	5	8
162	R:R:L73	R:R:Y91	3.52	Yes	Yes	4	5	5
163	R:R:L73	R:R:Y124	3.52	Yes	Yes	4	5	4
164	R:R:S84	R:R:W75	4.94	No	Yes	0	7	9
165	R:R:Q86	R:R:W75	10.95	No	Yes	0	5	9
166	R:R:K103	R:R:W75	11.6	Yes	Yes	0	8	9
167	R:R:S84	R:R:V78	6.46	No	No	0	7	7
168	R:R:E83	R:R:M85	9.47	No	No	0	3	4
169	R:R:S84	R:R:W111	3.71	No	Yes	0	7	9
170	R:R:K100	R:R:M85	5.76	No	No	0	3	4
171	R:R:C88	R:R:P89	3.77	No	No	0	9	8
172	R:R:C127	R:R:C88	7.28	No	No	0	9	9
173	R:R:P89	R:R:Y91	18.08	No	Yes	4	8	5
174	R:R:D90	R:R:P97	9.66	Yes	No	0	3	3
175	R:R:F92	R:R:Y91	5.16	Yes	Yes	4	6	5
176	R:R:F92	R:R:F95	7.5	Yes	Yes	4	6	5
177	R:R:D94	R:R:N128	6.73	No	No	0	5	3
178	R:R:C127	R:R:F95	4.19	No	Yes	0	9	5
179	R:R:F95	R:R:N128	9.67	Yes	No	4	5	3
180	R:R:D96	R:R:P97	4.83	Yes	No	0	5	3
181	R:R:D96	R:R:S98	5.89	Yes	No	6	5	3
182	R:R:D96	R:R:E99	11.69	Yes	No	6	5	5
183	R:R:E99	R:R:S98	5.75	No	No	6	5	3
184	R:R:V101	R:R:Y124	8.83	No	Yes	0	7	4
185	R:R:K103	R:R:W111	11.6	Yes	Yes	0	8	9
186	R:R:K103	R:R:T122	9.01	Yes	No	0	8	7
187	R:R:F112	R:R:I104	15.07	No	No	0	5	4
188	R:R:C105	R:R:W111	7.84	No	Yes	11	9	9
189	R:R:D106	R:R:N110	10.77	No	No	0	5	5
190	R:R:N110	R:R:R113	9.64	No	No	0	5	1
191	R:R:H114	R:R:P115	10.68	No	No	0	4	3
192	R:R:H114	R:R:W121	16.93	No	No	0	4	8
193	R:R:N123	R:R:W121	5.65	No	No	0	8	8
194	R:R:T122	R:R:Y124	6.24	No	Yes	4	7	4
195	R:R:N123	R:R:T125	13.16	No	No	0	8	6
196	R:R:E133	R:R:N130	11.83	No	No	0	1	2
197	R:R:K134	R:R:N130	4.2	No	No	0	3	2
198	R:R:E133	R:R:H132	3.69	No	No	0	1	2
199	R:R:L139	R:R:Y143	4.69	No	No	0	3	4
200	R:R:H370	R:R:L141	10.29	Yes	No	0	7	6
201	R:R:F142	R:R:Y143	6.19	Yes	No	0	6	4
202	R:R:F142	R:R:I146	11.3	Yes	No	0	6	6
203	R:R:F142	R:R:L195	4.87	Yes	No	0	6	7
204	R:R:F142	R:R:T196	5.19	Yes	No	0	6	3
205	R:R:F142	R:R:N200	7.25	Yes	No	0	6	3
206	R:R:H374	R:R:T145	13.69	Yes	No	0	9	7
207	R:R:I146	R:R:I192	4.42	No	No	0	6	6
208	R:R:H149	R:R:S188	12.55	Yes	No	0	7	8
209	R:R:H149	R:R:T191	6.85	Yes	Yes	0	7	7
210	R:R:H149	R:R:I192	5.3	Yes	No	0	7	6
211	R:R:H149	R:R:H374	14.33	Yes	Yes	0	7	9
212	R:R:G150	R:R:I153	5.29	No	No	0	7	6
213	R:R:G377	R:R:S152	3.71	No	No	0	9	9
214	R:R:I153	R:R:S188	6.19	No	No	0	6	8
215	R:R:L378	R:R:S155	6.01	No	No	0	6	6
216	R:R:S155	R:R:S381	6.52	No	No	0	6	8
217	R:R:F181	R:R:L156	8.53	No	No	0	8	9
218	R:R:F184	R:R:L156	4.87	Yes	No	0	8	9
219	R:R:L157	R:R:V185	4.47	No	No	0	3	7
220	R:R:F386	R:R:I158	3.77	Yes	No	0	8	5
221	R:R:F181	R:R:S159	5.28	No	Yes	0	8	8
222	R:R:S159	R:R:S381	4.89	Yes	No	12	8	8
223	R:R:C385	R:R:S159	6.89	No	Yes	0	9	8
224	R:R:F386	R:R:S159	3.96	Yes	Yes	12	8	8
225	R:R:F164	R:R:L160	3.65	No	No	0	4	5
226	R:R:F181	R:R:L160	4.87	No	No	0	8	5
227	R:R:F166	R:R:I162	3.77	Yes	No	0	7	8
228	R:R:F163	R:R:I174	3.77	No	Yes	13	7	9
229	R:R:F163	R:R:K178	3.72	No	No	13	7	6
230	R:R:C385	R:R:F163	9.78	No	No	0	9	7
231	R:R:F164	R:R:K178	19.85	No	No	0	4	6
232	R:R:F166	R:R:I394	3.77	Yes	Yes	0	7	8
233	R:R:F166	R:R:N398	4.83	Yes	No	0	7	5
234	R:R:C171	R:R:R173	5.57	No	No	0	8	9
235	R:R:C171	R:R:E248	4.56	No	No	0	8	6
236	R:R:Q172	R:R:Y236	10.15	Yes	Yes	3	7	8
237	R:R:E248	R:R:Q172	3.82	No	Yes	0	6	7
238	R:R:Q172	R:R:Q250	5.12	Yes	Yes	3	7	6
239	R:R:L252	R:R:Q172	15.97	Yes	Yes	3	6	7
240	R:R:I174	R:R:R173	6.26	Yes	No	0	9	9
241	R:R:E390	R:R:R173	9.3	No	No	0	9	9
242	R:R:H177	R:R:I174	3.98	No	Yes	0	9	9
243	R:R:I174	R:R:K178	5.82	Yes	No	13	9	6
244	R:R:E233	R:R:L176	7.95	Yes	No	0	9	9
245	R:R:L176	R:R:L252	4.15	No	Yes	3	9	6
246	R:R:L176	R:R:Y255	3.52	No	Yes	3	9	8
247	R:R:E233	R:R:H177	12.31	Yes	No	0	9	9
248	R:R:F384	R:R:H177	5.66	Yes	No	0	8	9
249	R:R:N179	R:R:W229	16.95	No	Yes	0	8	9
250	R:R:N179	R:R:Y256	10.47	No	No	0	8	5
251	R:R:F184	R:R:L180	4.87	Yes	No	0	8	9
252	R:R:E233	R:R:L180	7.95	Yes	No	0	9	9
253	R:R:C186	R:R:F182	8.38	No	No	0	7	4
254	R:R:N226	R:R:S183	5.96	Yes	No	2	8	8
255	R:R:S183	R:R:W229	8.65	No	Yes	2	8	9
256	R:R:S183	R:R:W260	4.94	No	Yes	2	8	9
257	R:R:F184	R:R:N226	16.92	Yes	Yes	2	8	8
258	R:R:F184	R:R:M230	3.73	Yes	Yes	2	8	9
259	R:R:F184	R:R:Q376	9.37	Yes	Yes	2	8	9
260	R:R:F184	R:R:G377	4.52	Yes	No	0	8	9
261	R:R:N187	R:R:T191	4.39	No	Yes	0	8	7
262	R:R:N187	R:R:N226	12.26	No	Yes	0	8	8
263	R:R:H219	R:R:V190	4.15	No	No	0	6	6
264	R:R:L222	R:R:V190	4.47	No	No	0	5	6
265	R:R:H219	R:R:T191	6.85	No	Yes	0	6	7
266	R:R:H194	R:R:V198	12.45	No	No	0	7	6
267	R:R:H194	R:R:Q216	8.65	No	Yes	0	7	6
268	R:R:V198	R:R:V205	6.41	No	Yes	0	6	4
269	R:R:A206	R:R:Q202	4.55	No	No	0	4	2
270	R:R:P209	R:R:T207	6.99	No	No	0	5	3
271	R:R:N208	R:R:N281	12.26	No	No	0	6	4
272	R:R:P209	R:R:S211	7.13	No	No	0	5	4
273	R:R:C212	R:R:P209	3.77	No	No	0	9	5
274	R:R:C212	R:R:C282	7.28	No	No	14	9	9
275	R:R:K213	R:R:N279	6.99	No	No	1	8	6
276	R:R:K213	R:R:W283	22.05	No	Yes	1	8	8
277	R:R:L220	R:R:Q216	5.32	Yes	Yes	1	7	6
278	R:R:Q216	R:R:W283	4.38	Yes	Yes	1	6	8
279	R:R:A267	R:R:F217	4.16	No	No	0	6	6
280	R:R:C268	R:R:F217	4.19	No	No	0	2	6
281	R:R:H270	R:R:L220	5.14	Yes	Yes	1	8	7
282	R:R:I294	R:R:L220	12.85	No	Yes	1	7	7
283	R:R:L222	R:R:Y221	4.69	No	No	0	5	8
284	R:R:C225	R:R:Y221	9.41	No	No	0	8	8
285	R:R:L264	R:R:Y221	9.38	No	No	0	3	8
286	R:R:M223	R:R:Y227	3.59	No	Yes	0	6	8
287	R:R:H295	R:R:M223	5.25	Yes	No	0	6	6
288	R:R:G224	R:R:I298	3.53	No	No	0	5	7
289	R:R:C225	R:R:W260	5.22	No	Yes	0	8	9
290	R:R:C225	R:R:P263	5.65	No	Yes	0	8	9
291	R:R:M230	R:R:N226	5.61	Yes	Yes	2	9	8
292	R:R:M230	R:R:Y227	5.99	Yes	Yes	2	9	8
293	R:R:I298	R:R:Y227	13.3	No	Yes	2	7	8
294	R:R:F349	R:R:Y227	9.28	Yes	Yes	2	8	8
295	R:R:F228	R:R:L258	3.65	Yes	Yes	5	5	6
296	R:R:F228	R:R:F262	7.5	Yes	Yes	5	5	4
297	R:R:F228	R:R:P263	4.33	Yes	Yes	5	5	9
298	R:R:C232	R:R:W229	5.22	No	Yes	0	7	9
299	R:R:G259	R:R:W229	8.44	No	Yes	0	9	9
300	R:R:W229	R:R:W260	19.68	Yes	Yes	2	9	9
301	R:R:M230	R:R:Q376	9.52	Yes	Yes	2	9	9
302	R:R:I235	R:R:L231	7.14	Yes	No	0	6	8
303	R:R:A301	R:R:L231	6.3	No	No	0	7	8
304	R:R:L231	R:R:N305	5.49	No	No	0	8	9
305	R:R:C232	R:R:Y255	4.03	No	Yes	0	7	8
306	R:R:C232	R:R:L258	4.76	No	Yes	0	7	6
307	R:R:E233	R:R:L344	5.3	Yes	No	0	9	9
308	R:R:G234	R:R:N305	5.09	No	No	0	8	9
309	R:R:I235	R:R:Y255	4.84	Yes	Yes	3	6	8
310	R:R:F308	R:R:I235	5.02	Yes	Yes	0	8	6
311	R:R:L240	R:R:Y236	15.24	No	Yes	0	8	8
312	R:R:Q250	R:R:Y236	6.76	Yes	Yes	3	6	8
313	R:R:Y236	R:R:Y255	7.94	Yes	Yes	3	8	8
314	R:R:I312	R:R:L237	4.28	No	No	0	9	9
315	R:R:L237	R:R:L341	4.15	No	No	0	9	9
316	R:R:H238	R:R:V242	13.84	No	No	0	8	6
317	R:R:F308	R:R:H238	22.63	Yes	No	0	8	8
318	R:R:Q250	R:R:T239	5.67	Yes	No	3	6	7
319	R:R:I241	R:R:I312	5.89	No	No	0	8	9
320	R:R:Q250	R:R:V245	7.16	Yes	Yes	3	6	7
321	R:R:A247	R:R:E248	4.53	No	No	0	6	6
322	R:R:Q250	R:R:Y255	7.89	Yes	Yes	3	6	8
323	R:R:H251	R:R:M253	3.94	No	No	0	4	3
324	R:R:L252	R:R:Y255	4.69	Yes	Yes	3	6	8
325	R:R:F262	R:R:L258	3.65	Yes	Yes	5	4	6
326	R:R:F262	R:R:P263	4.33	Yes	Yes	5	4	9
327	R:R:P266	R:R:P297	3.9	No	Yes	0	6	8
328	R:R:I269	R:R:I293	4.42	No	No	1	5	8
329	R:R:H270	R:R:R274	9.03	Yes	Yes	1	8	7
330	R:R:H270	R:R:I293	3.98	Yes	No	1	8	8
331	R:R:H270	R:R:I294	5.3	Yes	No	1	8	7
332	R:R:R274	R:R:Y278	7.2	Yes	Yes	1	7	6
333	R:R:D280	R:R:R274	8.34	Yes	Yes	1	4	7
334	R:R:R274	R:R:W283	23.99	Yes	Yes	1	7	8
335	R:R:R274	R:R:T288	3.88	Yes	No	1	7	5
336	R:R:L290	R:R:R274	4.86	Yes	Yes	1	3	7
337	R:R:S275	R:R:W283	4.94	No	Yes	0	3	8
338	R:R:L276	R:R:Y277	7.03	No	No	0	3	3
339	R:R:D280	R:R:Y278	8.05	Yes	Yes	1	4	6
340	R:R:S285	R:R:Y278	5.09	Yes	Yes	1	5	6
341	R:R:T288	R:R:Y278	22.47	No	Yes	1	5	6
342	R:R:N279	R:R:W283	6.78	No	Yes	1	6	8
343	R:R:D280	R:R:S285	4.42	Yes	Yes	1	4	5
344	R:R:L290	R:R:T288	4.42	Yes	No	1	3	5
345	R:R:H289	R:R:Y292	7.62	No	Yes	0	4	6
346	R:R:H295	R:R:L291	6.43	Yes	No	0	6	5
347	R:R:G296	R:R:P297	4.06	No	Yes	0	4	8
348	R:R:F349	R:R:L302	3.65	Yes	No	0	8	7
349	R:R:L302	R:R:V350	8.94	No	No	0	7	6
350	R:R:F308	R:R:V304	5.24	Yes	No	0	8	6
351	R:R:L345	R:R:N305	9.61	Yes	No	0	9	9
352	R:R:I347	R:R:L306	4.28	Yes	No	0	7	5
353	R:R:F307	R:R:F308	5.36	No	Yes	0	4	8
354	R:R:F307	R:R:N311	14.5	No	No	0	4	7
355	R:R:L309	R:R:L345	4.15	No	Yes	0	9	9
356	R:R:L316	R:R:L320	4.15	No	No	0	8	7
357	R:R:V335	R:R:Y331	3.79	No	No	0	8	7
358	R:R:A337	R:R:R336	4.15	No	No	0	9	8
359	R:R:I340	R:R:R336	5.01	No	No	0	8	8
360	R:R:P343	R:R:V342	5.3	No	No	0	9	8
361	R:R:I347	R:R:V342	7.68	Yes	No	0	7	8
362	R:R:E348	R:R:V342	4.28	Yes	No	0	8	8
363	R:R:L344	R:R:L345	4.15	No	Yes	0	9	9
364	R:R:F384	R:R:L344	15.83	Yes	No	0	8	9
365	R:R:I347	R:R:L345	5.71	Yes	Yes	0	7	9
366	R:R:E348	R:R:G346	4.91	Yes	No	0	8	9
367	R:R:I347	R:R:L351	4.28	Yes	No	0	7	5
368	R:R:E348	R:R:F349	9.33	Yes	Yes	2	8	8
369	R:R:E348	R:R:L372	7.95	Yes	Yes	2	8	6
370	R:R:E348	R:R:Q376	10.19	Yes	Yes	2	8	9
371	R:R:F349	R:R:L372	3.65	Yes	Yes	2	8	6
372	R:R:F349	R:R:M373	6.22	Yes	No	0	8	7
373	R:R:F349	R:R:Q376	5.86	Yes	Yes	2	8	9
374	R:R:I352	R:R:M369	5.83	No	Yes	0	7	8
375	R:R:W354	R:R:Y365	3.86	No	No	0	5	6
376	R:R:D366	R:R:H370	5.04	No	Yes	0	6	7
377	R:R:I368	R:R:Y367	3.63	No	No	0	4	6
378	R:R:I371	R:R:Y367	3.63	No	No	0	6	6
379	R:R:L372	R:R:M369	4.24	Yes	Yes	0	6	8
380	R:R:H370	R:R:H374	8.36	Yes	Yes	0	7	9
381	R:R:H374	R:R:M373	7.88	Yes	No	0	9	7
382	R:R:F384	R:R:V380	3.93	Yes	No	0	8	9
383	R:R:F386	R:R:S381	3.96	Yes	No	12	8	8
384	R:R:F386	R:R:T382	3.89	Yes	No	0	8	5
385	R:R:F387	R:R:T382	5.19	No	No	0	5	5
386	R:R:F384	R:R:I383	7.54	Yes	No	0	8	7
387	R:R:E390	R:R:N388	14.46	No	No	0	9	9
388	R:R:N388	R:R:V391	7.39	No	No	0	9	9
389	R:R:Q392	R:R:R396	9.35	No	No	0	7	5
390	R:R:N398	R:R:Q401	5.28	No	No	0	5	6
391	R:R:N400	R:R:Q401	3.96	No	No	0	4	6
392	E:E:P85	R:R:T120	3.5	No	No	0	9	5
393	E:E:T130	R:R:P297	3.5	No	Yes	0	9	8
394	L:L:G13	R:R:M369	3.49	No	Yes	0	0	8
395	R:R:C212	R:R:V205	3.42	No	Yes	14	9	4
396	R:R:C282	R:R:V205	3.42	No	Yes	14	9	4
397	E:E:I125	E:E:P126	3.39	No	No	0	5	9
398	E:E:R140	R:R:H251	3.39	No	No	0	8	4
399	R:R:I265	R:R:P266	3.39	No	No	0	4	6
400	R:R:A79	R:R:T82	3.36	No	No	0	1	5
401	L:L:W25	R:R:Q202	3.29	No	No	0	0	2
402	E:E:P114	R:R:L290	3.28	Yes	Yes	0	9	3
403	R:R:L379	R:R:P343	3.28	No	No	0	5	9
404	R:R:C74	R:R:I52	3.27	No	Yes	0	9	5
405	R:R:E362	R:R:W354	3.27	No	No	0	6	5
406	R:R:A199	R:R:I284	3.25	No	No	0	4	6
407	L:L:D40	L:L:P41	3.22	Yes	No	0	0	0
408	R:R:V242	R:R:V243	3.21	No	No	0	6	5
409	R:R:V243	R:R:V245	3.21	No	Yes	0	5	7
410	R:R:T82	R:R:V78	3.17	No	No	0	5	7
411	R:R:T338	R:R:V313	3.17	No	No	0	9	6
412	R:R:A273	R:R:L290	3.15	No	Yes	0	5	3
413	R:R:I153	R:R:V189	3.07	No	No	0	6	4
414	R:R:I193	R:R:V189	3.07	No	No	0	5	4
415	R:R:I241	R:R:V315	3.07	No	No	0	8	8
416	R:R:I317	R:R:V313	3.07	No	No	0	5	6
417	E:E:I93	E:E:T94	3.04	No	No	0	9	7
418	E:E:T94	R:R:M53	3.01	No	No	0	7	2
419	R:R:M85	R:R:T102	3.01	No	No	0	4	5
420	R:R:F375	R:R:G148	3.01	No	No	0	7	9
421	R:R:K103	R:R:T120	3	Yes	No	0	8	5
422	R:R:L156	R:R:V185	2.98	No	No	0	9	7
423	R:R:L309	R:R:V313	2.98	No	No	0	9	6
424	R:R:L395	R:R:V391	2.98	No	No	0	5	9
425	E:E:L59	R:R:T43	2.95	No	No	0	7	5
426	R:R:L252	R:R:T175	2.95	Yes	No	0	6	6
427	R:R:L339	R:R:T338	2.95	No	No	0	7	9
428	R:R:I317	R:R:K321	2.91	No	No	0	5	6
429	E:E:F92	E:E:P38	2.89	No	No	0	8	5
430	R:R:D96	R:R:T131	2.89	Yes	No	0	5	1
431	E:E:P87	R:R:R119	2.88	No	Yes	0	5	4
432	E:E:V106	R:R:Q50	2.87	No	No	0	4	4
433	R:R:Q202	R:R:V205	2.87	No	Yes	0	2	4
434	E:E:I123	E:E:L119	2.85	No	No	0	9	9
435	R:R:I394	R:R:L169	2.85	Yes	No	0	8	9
436	R:R:I218	R:R:L222	2.85	No	No	0	5	5
437	E:E:L34	E:E:M33	2.83	No	No	0	5	8
438	E:E:T70	R:R:Q45	2.83	No	No	0	9	5
439	R:R:Q126	R:R:T125	2.83	No	No	0	5	6
440	E:E:M75	E:E:N71	2.8	No	No	0	1	4
441	R:R:M42	R:R:N39	2.8	No	No	0	3	5
442	R:R:H194	R:R:S215	2.79	No	No	0	7	6
443	E:E:V138	R:R:H238	2.77	No	No	0	9	8
444	R:R:D96	R:R:K134	2.77	Yes	No	0	5	3
445	R:R:L151	R:R:L378	2.77	No	No	0	5	6
446	R:R:A271	R:R:F217	2.77	No	No	0	5	6
447	R:R:L306	R:R:L310	2.77	No	No	0	5	5
448	R:R:L309	R:R:L341	2.77	No	No	0	9	9
449	E:E:C57	R:R:Y46	2.69	No	Yes	0	9	2
450	R:R:A79	R:R:Y64	2.67	No	No	0	1	3
451	R:R:A80	R:R:Y64	2.67	No	No	0	6	3
452	R:R:E390	R:R:L169	2.65	No	No	0	9	9
453	L:L:R33	R:R:V36	2.62	Yes	No	0	0	2
454	L:L:D35	R:R:Q93	2.61	No	No	0	0	4
455	R:R:A271	R:R:W283	2.59	No	Yes	0	5	8
456	R:R:V364	R:R:Y365	2.52	No	No	0	4	6
457	R:R:F246	R:R:K249	2.48	No	No	0	6	5
458	E:E:V51	E:E:W56	2.45	No	Yes	0	6	7
459	E:E:V53	E:E:W54	2.45	No	No	0	4	3
460	L:L:V11	R:R:W354	2.45	No	No	0	0	5
461	E:E:L129	R:R:F262	2.44	No	Yes	0	7	4
462	E:E:N86	R:R:R119	2.41	No	Yes	0	9	4
463	R:R:N66	R:R:R67	2.41	No	No	0	5	4
464	R:R:M332	R:R:Y331	2.39	No	No	0	6	7
465	E:E:L59	R:R:Y46	2.34	No	Yes	0	7	2
466	L:L:W25	R:R:N281	2.26	No	No	0	0	4
467	R:R:Q50	R:R:Y46	2.25	No	Yes	0	4	2
468	R:R:R113	R:R:R119	2.13	No	Yes	0	1	4
469	E:E:F44	E:E:Y65	2.06	No	No	0	9	5
470	R:R:G261	R:R:P263	2.03	No	Yes	0	7	9
471	R:R:F182	R:R:W260	2	No	Yes	0	4	9
472	R:R:C299	R:R:G296	1.96	No	No	0	4	4
473	E:E:P114	E:E:P115	1.95	Yes	No	0	9	8
474	E:E:A134	E:E:G135	1.95	No	No	0	8	7
475	L:L:A31	L:L:G32	1.95	No	No	0	0	0
476	E:E:V127	R:R:G296	1.84	No	No	0	7	4
477	E:E:G91	E:E:T94	1.82	No	No	0	4	7
478	R:R:G81	R:R:T82	1.82	No	No	0	7	5
479	L:L:P38	L:L:S36	1.78	No	No	0	0	0
480	R:R:G148	R:R:I147	1.76	No	No	0	9	5
481	E:E:C82	E:E:V80	1.71	No	No	0	9	5
482	R:R:G161	R:R:L160	1.71	No	No	0	1	5
483	E:E:V127	R:R:A300	1.7	No	No	0	7	3
484	R:R:A197	R:R:V198	1.7	No	No	0	5	6
485	R:R:G389	R:R:N388	1.7	No	No	0	6	9
486	R:R:I352	R:R:P353	1.69	No	No	0	7	6
487	L:L:G9	R:R:D287	1.68	No	No	0	0	3
488	E:E:K42	E:E:P38	1.67	No	No	0	3	5
489	E:E:L88	E:E:P87	1.64	No	No	0	6	5
490	R:R:G389	R:R:Q392	1.64	No	No	0	6	7
491	R:R:A334	R:R:I317	1.62	No	No	0	8	5
492	E:E:V79	E:E:V80	1.6	No	No	0	1	5
493	E:E:V124	E:E:V128	1.6	No	No	0	4	4
494	E:E:V131	R:R:V304	1.6	No	No	0	6	6
495	R:R:G148	R:R:H374	1.59	No	Yes	0	9	9
496	L:L:L24	R:R:A138	1.58	No	No	0	0	5
497	L:L:L27	R:R:A138	1.58	Yes	No	0	0	5
498	R:R:A197	R:R:L204	1.58	No	No	0	5	4
499	R:R:A337	R:R:L316	1.58	No	No	0	9	8
500	E:E:A77	E:E:N78	1.56	No	No	0	7	1
501	R:R:I394	R:R:S168	1.55	Yes	No	0	8	7
502	E:E:K55	E:E:V51	1.52	No	No	0	4	6
503	R:R:K249	R:R:V245	1.52	No	Yes	0	5	7
504	R:R:K319	R:R:V315	1.52	No	No	0	9	8
505	E:E:G95	E:E:R98	1.5	No	No	0	3	6
506	R:R:L303	R:R:V350	1.49	No	No	0	3	6
507	L:L:S36	R:R:D94	1.47	No	No	0	0	5
508	R:R:L141	R:R:T137	1.47	No	No	0	6	4
509	R:R:D287	R:R:S285	1.47	No	Yes	0	3	5
510	R:R:D287	R:R:S286	1.47	No	No	0	3	7
511	R:R:I340	R:R:I383	1.47	No	No	0	8	7
512	R:R:I371	R:R:L144	1.43	No	No	0	6	6
513	R:R:I368	R:R:L372	1.43	No	Yes	0	4	6
514	R:R:I52	R:R:N76	1.42	Yes	No	0	5	6
515	E:E:G49	E:E:W56	1.41	No	Yes	0	3	7
516	R:R:K321	R:R:L330	1.41	No	No	0	6	6
517	E:E:K55	E:E:N58	1.4	No	No	0	4	8
518	L:L:L5	L:L:L6	1.38	No	No	0	0	0
519	R:R:L139	R:R:N140	1.37	No	No	0	3	4
520	R:R:L204	R:R:N201	1.37	No	No	0	4	4
521	R:R:L330	R:R:N329	1.37	No	No	0	6	5
522	R:R:E133	R:R:K136	1.35	No	No	0	1	2
523	R:R:A44	R:R:Y91	1.33	No	Yes	0	6	5
524	R:R:D366	R:R:E363	1.3	No	No	0	6	4
525	R:R:R314	R:R:T318	1.29	No	No	0	7	7
526	E:E:V118	R:R:Y277	1.26	No	No	0	7	3
527	R:R:I394	R:R:R397	1.25	Yes	No	0	8	7
528	R:R:K333	R:R:R336	1.24	No	No	0	8	8
529	E:E:L39	E:E:R36	1.21	No	Yes	0	1	3
530	R:R:N311	R:R:R314	1.21	No	No	0	7	7
531	R:R:D106	R:R:F112	1.19	No	No	0	5	5
532	R:R:F166	R:R:Y165	1.03	Yes	No	0	7	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:R36	5.2825	4	0	3
2	E:E:M48	6.1	4	7	9
3	E:E:W56	7.582	5	7	7
4	E:E:F62	7.46	4	0	8
5	E:E:F69	8.246	5	8	8
6	E:E:F100	7.728	5	7	8
7	E:E:F101	11.2325	4	7	9
8	E:E:P114	7.03	4	0	9
9	L:L:Q18	4.8325	4	1	0
10	L:L:R23	10.065	4	6	0
11	L:L:L27	6.4775	4	6	0
12	L:L:R33	9.932	5	9	0
13	L:L:D40	5.258	5	4	0
14	R:R:Y46	5.65	5	0	2
15	R:R:I52	5.7075	4	0	5
16	R:R:W69	8.0075	4	10	7
17	R:R:W72	11.174	5	4	5
18	R:R:L73	6.22	4	4	5
19	R:R:W75	7.12	5	0	9
20	R:R:D90	8.53	4	9	3
21	R:R:Y91	7.00167	6	4	5
22	R:R:F92	6.2175	4	4	6
23	R:R:F95	6.8325	4	4	5
24	R:R:D96	6.12286	7	6	5
25	R:R:K103	8.8025	4	0	8
26	R:R:W111	8.96	5	11	9
27	R:R:R119	4.17	4	0	4
28	R:R:Y124	7.71667	6	4	4
29	R:R:F142	6.40833	6	0	6
30	R:R:H149	9.7575	4	0	7
31	R:R:S159	5.255	4	12	8
32	R:R:F166	3.35	4	0	7
33	R:R:Q172	8.765	4	3	7
34	R:R:I174	4.9575	4	13	9
35	R:R:F184	7.38	6	2	8
36	R:R:T191	5.7125	4	0	7
37	R:R:V205	4.03	4	14	4
38	R:R:Q216	6.1875	4	1	6
39	R:R:L220	6.825	4	1	7
40	R:R:N226	10.1875	4	2	8
41	R:R:Y227	7.68	5	2	8
42	R:R:F228	6.14	4	5	5
43	R:R:W229	11.788	5	2	9
44	R:R:M230	6.2125	4	2	9
45	R:R:E233	8.3775	4	0	9
46	R:R:I235	5.4025	4	3	6
47	R:R:Y236	10.0225	4	3	8
48	R:R:V245	4.5875	4	3	7
49	R:R:Q250	6.155	6	3	6
50	R:R:L252	6.94	4	3	6
51	R:R:Y255	5.42286	7	3	8
52	R:R:L258	4.075	4	5	6
53	R:R:W260	7.96	4	2	9
54	R:R:F262	5.08667	6	5	4
55	R:R:P263	4.085	4	5	9
56	R:R:H270	5.8625	4	1	8
57	R:R:R274	9.55	6	1	7
58	R:R:Y278	11.61	5	1	6
59	R:R:D280	6.22	4	1	4
60	R:R:W283	10.7883	6	1	8
61	R:R:S285	3.79	4	1	5
62	R:R:L290	3.9275	4	1	3
63	R:R:Y292	4.892	5	0	6
64	R:R:H295	7.22	5	2	6
65	R:R:P297	4.325	4	0	8
66	R:R:F308	9.5625	4	0	8
67	R:R:L345	5.905	4	0	9
68	R:R:I347	5.4875	4	0	7
69	R:R:E348	7.332	5	2	8
70	R:R:F349	6.33167	6	2	8
71	R:R:M369	5.09	4	0	8
72	R:R:H370	8.724	5	0	7
73	R:R:L372	4.3175	4	2	6
74	R:R:H374	9.17	5	0	9
75	R:R:Q376	8.735	4	2	9
76	R:R:F384	8.24	4	0	8
77	R:R:F386	3.895	4	12	8
78	R:R:I394	2.355	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:L34	E:E:R36	10.9838	3.64	No	Yes	0	5	3
2	E:E:F101	E:E:F62	21.2632	7.5	Yes	Yes	0	9	8
3	E:E:F62	E:E:I63	31.3874	3.77	Yes	No	0	8	6
4	E:E:I63	R:R:M42	31.7702	5.83	No	No	0	6	3
5	E:E:E67	R:R:M42	32.5313	4.06	No	No	0	4	3
6	E:E:E67	R:R:R38	33.6607	4.65	No	No	0	4	5
7	R:R:I41	R:R:R38	34.0347	3.76	No	No	0	6	5
8	R:R:I41	R:R:W72	34.4073	3.52	No	Yes	0	6	5
9	R:R:W72	R:R:Y124	20.9752	17.36	Yes	Yes	4	5	4
10	R:R:T122	R:R:Y124	27.8134	6.24	No	Yes	4	7	4
11	R:R:K103	R:R:T122	27.0559	9.01	Yes	No	0	8	7
12	R:R:K103	R:R:T120	34.9709	3	Yes	No	0	8	5
13	E:E:P85	R:R:T120	33.7854	3.5	No	No	0	9	5
14	E:E:P85	E:E:Y83	32.5984	6.95	No	No	0	9	6
15	E:E:Y83	R:R:R119	25.446	9.26	No	Yes	0	6	4
16	E:E:N86	R:R:R119	15.8278	2.41	No	Yes	0	9	4
17	E:E:L34	E:E:N86	13.4087	4.12	No	No	0	5	9
18	E:E:F101	E:E:M48	13.1667	4.98	Yes	Yes	7	9	9
19	E:E:P114	R:R:L290	26.0964	3.28	Yes	Yes	0	9	3
20	R:R:L290	R:R:R274	22.9744	4.86	Yes	Yes	1	3	7
21	R:R:R274	R:R:Y278	21.0839	7.2	Yes	Yes	1	7	6
22	R:R:S285	R:R:Y278	26.1518	5.09	Yes	Yes	1	5	6
23	L:L:H22	R:R:S285	42.1714	4.18	No	Yes	0	0	5
24	L:L:H22	L:L:Q26	40.2386	22.25	No	No	0	0	0
25	L:L:Q26	L:L:R23	39.952	5.84	No	Yes	0	0	0
26	L:L:R23	R:R:D96	38.3057	10.72	Yes	Yes	6	0	5
27	R:R:D96	R:R:P97	100	4.83	Yes	No	0	5	3
28	R:R:D90	R:R:P97	99.8381	9.66	Yes	No	0	3	3
29	R:R:D90	R:R:K40	90.9381	4.15	Yes	No	0	3	5
30	R:R:K40	R:R:Y91	90.7515	7.17	No	Yes	0	5	5
31	R:R:W72	R:R:Y91	47.9917	6.75	Yes	Yes	4	5	5
32	R:R:D280	R:R:R274	21.0846	8.34	Yes	Yes	1	4	7
33	R:R:D280	R:R:S285	20.5196	4.42	Yes	Yes	1	4	5
34	R:R:L73	R:R:Y91	35.4696	3.52	Yes	Yes	4	5	5
35	R:R:L73	R:R:Y124	17.1256	3.52	Yes	Yes	4	5	4
36	R:R:L73	R:R:Q86	18.3359	7.99	Yes	No	0	5	5
37	R:R:Q86	R:R:W75	17.8584	10.95	No	Yes	0	5	9
38	R:R:K103	R:R:W75	12.4522	11.6	Yes	Yes	0	8	9
39	E:E:L119	E:E:P114	16.6882	18.06	No	Yes	0	9	9
40	R:R:H270	R:R:R274	16.9383	9.03	Yes	Yes	1	8	7
41	E:E:I123	E:E:L119	15.5056	2.85	No	No	0	9	9
42	E:E:I123	R:R:Y292	14.3215	4.84	No	Yes	0	9	6
43	L:L:L27	R:R:D96	62.9483	4.07	Yes	Yes	6	0	5
44	L:L:L27	R:R:A138	64.4109	1.58	Yes	No	0	0	5
45	L:L:L24	R:R:A138	64.3241	1.58	No	No	0	0	5
46	L:L:L24	R:R:F142	64.2774	3.65	No	Yes	0	0	6
47	R:R:F142	R:R:I146	64.2774	11.3	Yes	No	0	6	6
48	R:R:I146	R:R:I192	64.3321	4.42	No	No	0	6	6
49	R:R:H149	R:R:I192	64.397	5.3	Yes	No	0	7	6
50	R:R:H149	R:R:T191	53.1967	6.85	Yes	Yes	0	7	7
51	R:R:N187	R:R:T191	56.8203	4.39	No	Yes	0	8	7
52	R:R:N187	R:R:N226	56.6854	12.26	No	Yes	0	8	8
53	R:R:N226	R:R:S183	36.2789	5.96	Yes	No	2	8	8
54	R:R:S183	R:R:W229	25.9119	8.65	No	Yes	2	8	9
55	R:R:C232	R:R:W229	25.96	5.22	No	Yes	0	7	9
56	R:R:C232	R:R:L258	12.6177	4.76	No	Yes	0	7	6
57	E:E:T130	R:R:F228	11.2127	9.08	No	Yes	5	9	5
58	E:E:T130	R:R:P297	20.2097	3.5	No	Yes	0	9	8
59	R:R:C225	R:R:P263	16.8901	5.65	No	Yes	0	8	9
60	R:R:H219	R:R:T191	25.9564	6.85	No	Yes	0	6	7
61	R:R:H219	R:R:V190	11.5182	4.15	No	No	0	6	6
62	R:R:L222	R:R:V190	11.1427	4.47	No	No	0	5	6
63	R:R:L222	R:R:Y221	10.733	4.69	No	No	0	5	8
64	R:R:C225	R:R:Y221	10.5915	9.41	No	No	0	8	8
65	E:E:T130	R:R:F262	11.2346	3.89	No	Yes	5	9	4
66	R:R:C232	R:R:Y255	21.6511	4.03	No	Yes	0	7	8
67	R:R:H270	R:R:L220	15.6346	5.14	Yes	Yes	1	8	7
68	L:L:Q18	R:R:L220	15.596	3.99	Yes	Yes	1	0	7
69	L:L:Q18	R:R:L291	14.2122	3.99	Yes	No	0	0	5
70	R:R:H295	R:R:L291	13.4802	6.43	Yes	No	0	6	5
71	R:R:R274	R:R:W283	27.0172	23.99	Yes	Yes	1	7	8
72	R:R:Q216	R:R:W283	25.3607	4.38	Yes	Yes	1	6	8
73	L:L:Q18	R:R:Q216	20.887	6.4	Yes	Yes	1	0	6
74	R:R:H149	R:R:H374	18.1449	14.33	Yes	Yes	0	7	9
75	R:R:H374	R:R:M373	13.3883	7.88	Yes	No	0	9	7
76	R:R:F349	R:R:M373	12.7008	6.22	Yes	No	0	8	7
77	R:R:F349	R:R:Y227	10.0002	9.28	Yes	Yes	2	8	8
78	R:R:H194	R:R:Q216	13.478	8.65	No	Yes	0	7	6
79	R:R:H194	R:R:V198	12.084	12.45	No	No	0	7	6
80	L:L:D40	L:L:S46	11.0078	4.42	Yes	No	0	0	0
81	R:R:F184	R:R:N226	28.1553	16.92	Yes	Yes	2	8	8
82	R:R:F184	R:R:L180	22.5158	4.87	Yes	No	0	8	9
83	R:R:E233	R:R:L180	22.2183	7.95	Yes	No	0	9	9
84	R:R:E233	R:R:H177	14.6934	12.31	Yes	No	0	9	9
85	R:R:H177	R:R:I174	11.3359	3.98	No	Yes	0	9	9
86	R:R:E390	R:R:R173	10.8897	9.3	No	No	0	9	9
87	R:R:E348	R:R:F349	12.719	9.33	Yes	Yes	2	8	8
88	R:R:E348	R:R:V342	13.0923	4.28	Yes	No	0	8	8
89	R:R:I347	R:R:V342	11.7974	7.68	Yes	No	0	7	8
90	R:R:I347	R:R:L345	10.4122	5.71	Yes	Yes	0	7	9
91	R:R:L309	R:R:L345	11.2528	4.15	No	Yes	0	9	9
92	R:R:F92	R:R:F95	12.221	7.5	Yes	Yes	4	6	5
93	L:L:Q18	R:R:H219	22.0382	4.95	Yes	No	0	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E74	E:E:W84	37.07	0	No	No	5	9	2	1
E:E:Y83	R:R:S117	10.17	0	No	No	6	4	2	1
E:E:W84	L:L:Y47	16.4	0	No	No	9	0	1	0
E:E:I123	R:R:Y292	4.84	0	No	Yes	9	6	2	1
L:L:L6	R:R:Y292	4.69	0	No	Yes	0	6	0	1
L:L:C10	R:R:H295	4.42	2	No	Yes	0	6	0	1
L:L:V11	R:R:Y292	3.79	0	No	Yes	0	6	0	1
L:L:L12	R:R:Y292	3.52	0	No	Yes	0	6	0	1
L:L:T14	R:R:Y227	6.24	2	No	Yes	0	8	0	1
L:L:T14	R:R:H295	8.21	2	No	Yes	0	6	0	1
L:L:T14	R:R:I298	6.08	2	No	No	0	7	0	1
L:L:C15	R:R:H295	11.79	2	No	Yes	0	6	0	1
L:L:Q16	R:R:M369	6.8	0	No	Yes	0	8	0	1
L:L:Q16	R:R:H370	16.07	0	No	Yes	0	7	0	1
L:L:Q16	R:R:M373	4.08	0	No	No	0	7	0	1
L:L:V17	R:R:T191	4.76	0	No	Yes	0	7	0	1
L:L:Q18	R:R:Q216	6.4	1	Yes	Yes	0	6	0	1
L:L:Q18	R:R:H219	4.95	1	Yes	No	0	6	0	1
L:L:Q18	R:R:L220	3.99	1	Yes	Yes	0	7	0	1
L:L:Q18	R:R:L291	3.99	1	Yes	No	0	5	0	1
L:L:N19	R:R:S286	4.47	0	No	No	0	7	0	1
L:L:L20	R:R:H370	3.86	0	No	Yes	0	7	0	1
L:L:S21	R:R:L195	4.5	0	No	No	0	7	0	1
L:L:H22	R:R:S285	4.18	0	No	Yes	0	5	0	1
L:L:H22	R:R:S286	8.37	0	No	No	0	7	0	1
L:L:R23	R:R:D96	10.72	6	Yes	Yes	0	5	0	1
L:L:R23	R:R:S98	7.91	6	Yes	No	0	3	0	1
L:L:L24	R:R:F142	3.65	0	No	Yes	0	6	0	1
L:L:W25	R:R:I284	11.74	0	No	No	0	6	0	1
L:L:L27	R:R:D96	4.07	6	Yes	Yes	0	5	0	1
L:L:L27	R:R:V135	4.47	6	Yes	No	0	1	0	1
L:L:M28	R:R:L139	4.24	0	No	No	0	3	0	1
L:L:P30	R:R:D90	4.83	9	No	Yes	0	3	0	1
L:L:R33	R:R:T37	3.88	9	Yes	No	0	4	0	1
L:L:R33	R:R:D90	15.48	9	Yes	Yes	0	3	0	1
L:L:R33	R:R:Q93	23.36	9	Yes	No	0	4	0	1
L:L:Q34	R:R:T37	11.34	0	No	No	0	4	0	1
L:L:D40	R:R:F95	5.97	4	Yes	Yes	0	5	0	1
L:L:D40	R:R:Y124	4.6	4	Yes	Yes	0	4	0	1
L:L:D40	R:R:N128	8.08	4	Yes	No	0	3	0	1
L:L:P44	R:R:S117	3.56	0	No	No	0	4	0	1
L:L:S46	R:R:W121	6.18	0	No	No	0	8	0	1
L:L:Y47	R:R:W72	21.22	0	No	Yes	0	5	0	1
R:R:F92	R:R:T37	5.19	4	Yes	No	6	4	2	1
R:R:D90	R:R:K40	4.15	9	Yes	No	3	5	1	2
R:R:K40	R:R:Y91	7.17	0	No	Yes	5	5	2	2
R:R:I41	R:R:W72	3.52	0	No	Yes	6	5	2	1
R:R:D70	R:R:T122	7.23	4	No	No	9	7	2	2
R:R:D70	R:R:Y124	5.75	4	No	Yes	9	4	2	1
R:R:W72	R:R:Y91	6.75	4	Yes	Yes	5	5	1	2
R:R:F92	R:R:W72	7.02	4	Yes	Yes	6	5	2	1
R:R:W72	R:R:Y124	17.36	4	Yes	Yes	5	4	1	1
R:R:L73	R:R:Y91	3.52	4	Yes	Yes	5	5	2	2
R:R:L73	R:R:Y124	3.52	4	Yes	Yes	5	4	2	1
R:R:D90	R:R:P97	9.66	9	Yes	No	3	3	1	2
R:R:F92	R:R:Y91	5.16	4	Yes	Yes	6	5	2	2
R:R:F92	R:R:F95	7.5	4	Yes	Yes	6	5	2	1
R:R:D94	R:R:N128	6.73	0	No	No	5	3	1	1
R:R:C127	R:R:F95	4.19	0	No	Yes	9	5	2	1
R:R:F95	R:R:N128	9.67	4	Yes	No	5	3	1	1
R:R:D96	R:R:P97	4.83	6	Yes	No	5	3	1	2
R:R:D96	R:R:S98	5.89	6	Yes	No	5	3	1	1
R:R:D96	R:R:E99	11.69	6	Yes	No	5	5	1	2
R:R:E99	R:R:S98	5.75	6	No	No	5	3	2	1
R:R:V101	R:R:Y124	8.83	0	No	Yes	7	4	2	1
R:R:H114	R:R:W121	16.93	0	No	No	4	8	2	1
R:R:N123	R:R:W121	5.65	0	No	No	8	8	2	1
R:R:T122	R:R:Y124	6.24	4	No	Yes	7	4	2	1
R:R:L139	R:R:Y143	4.69	0	No	No	3	4	1	2
R:R:H370	R:R:L141	10.29	0	Yes	No	7	6	1	2
R:R:F142	R:R:Y143	6.19	0	Yes	No	6	4	1	2
R:R:F142	R:R:I146	11.3	0	Yes	No	6	6	1	2
R:R:F142	R:R:L195	4.87	0	Yes	No	6	7	1	1
R:R:F142	R:R:T196	5.19	0	Yes	No	6	3	1	2
R:R:F142	R:R:N200	7.25	0	Yes	No	6	3	1	2
R:R:H149	R:R:T191	6.85	0	Yes	Yes	7	7	2	1
R:R:H149	R:R:H374	14.33	0	Yes	Yes	7	9	2	2
R:R:N187	R:R:T191	4.39	0	No	Yes	8	7	2	1
R:R:H219	R:R:V190	4.15	0	No	No	6	6	1	2
R:R:H219	R:R:T191	6.85	0	No	Yes	6	7	1	1
R:R:H194	R:R:Q216	8.65	0	No	Yes	7	6	2	1
R:R:A206	R:R:Q202	4.55	0	No	No	4	2	2	1
R:R:N208	R:R:N281	12.26	0	No	No	6	4	2	1
R:R:L220	R:R:Q216	5.32	1	Yes	Yes	7	6	1	1
R:R:Q216	R:R:W283	4.38	1	Yes	Yes	6	8	1	2
R:R:H270	R:R:L220	5.14	1	Yes	Yes	8	7	2	1
R:R:I294	R:R:L220	12.85	1	No	Yes	7	7	2	1
R:R:M223	R:R:Y227	3.59	0	No	Yes	6	8	2	1
R:R:H295	R:R:M223	5.25	2	Yes	No	6	6	1	2
R:R:G224	R:R:I298	3.53	0	No	No	5	7	2	1
R:R:M230	R:R:Y227	5.99	2	Yes	Yes	9	8	2	1
R:R:I298	R:R:Y227	13.3	2	No	Yes	7	8	1	1
R:R:F349	R:R:Y227	9.28	2	Yes	Yes	8	8	2	1
R:R:H270	R:R:I294	5.3	1	Yes	No	8	7	2	2
R:R:D280	R:R:Y278	8.05	1	Yes	Yes	4	6	2	2
R:R:S285	R:R:Y278	5.09	1	Yes	Yes	5	6	1	2
R:R:D280	R:R:S285	4.42	1	Yes	Yes	4	5	2	1
R:R:H289	R:R:Y292	7.62	0	No	Yes	4	6	2	1
R:R:H295	R:R:L291	6.43	2	Yes	No	6	5	1	1
R:R:F349	R:R:L372	3.65	2	Yes	Yes	8	6	2	2
R:R:F349	R:R:M373	6.22	2	Yes	No	8	7	2	1
R:R:I352	R:R:M369	5.83	0	No	Yes	7	8	2	1
R:R:W354	R:R:Y365	3.86	0	No	No	5	6	1	2
R:R:D366	R:R:H370	5.04	0	No	Yes	6	7	2	1
R:R:L372	R:R:M369	4.24	2	Yes	Yes	6	8	2	1
R:R:H370	R:R:H374	8.36	0	Yes	Yes	7	9	1	2
R:R:H374	R:R:M373	7.88	0	Yes	No	9	7	2	1
L:L:G13	R:R:M369	3.49	0	No	Yes	0	8	0	1
L:L:W25	R:R:Q202	3.29	0	No	No	0	2	0	1
R:R:E362	R:R:W354	3.27	0	No	No	6	5	2	1
R:R:A199	R:R:I284	3.25	0	No	No	4	6	2	1
R:R:D96	R:R:T131	2.89	6	Yes	No	5	1	1	2
R:R:Q202	R:R:V205	2.87	0	No	Yes	2	4	1	2
R:R:D96	R:R:K134	2.77	6	Yes	No	5	3	1	2
L:L:R33	R:R:V36	2.62	9	Yes	No	0	2	0	1
L:L:D35	R:R:Q93	2.61	0	No	No	0	4	0	1
L:L:V11	R:R:W354	2.45	0	No	No	0	5	0	1
L:L:W25	R:R:N281	2.26	0	No	No	0	4	0	1
L:L:G9	R:R:D287	1.68	0	No	No	0	3	0	1
L:L:L24	R:R:A138	1.58	0	No	No	0	5	0	1
L:L:L27	R:R:A138	1.58	6	Yes	No	0	5	0	1
L:L:S36	R:R:D94	1.47	0	No	No	0	5	0	1
R:R:D287	R:R:S285	1.47	0	No	Yes	3	5	1	1
R:R:D287	R:R:S286	1.47	0	No	No	3	7	1	1
R:R:L139	R:R:N140	1.37	0	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6UVA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	467
Number of Links	532
Number of Hubs	78
Number of Links mediated by Hubs	282
Number of Communities	14
Number of Nodes involved in Communities	92
Number of Links involved in Communities	125

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	252850
Length Of Smallest Path	3
Average Path Length	20.6408
Length of Longest Path	44
Minimum Path Strength	1.25
Average Path Strength	6.55346
Maximum Path Strength	26.735
Minimum Path Correlation	0.7
Average Path Correlation	0.968235
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	59.0921
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0335
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • amyloid-beta binding • peptide binding • molecular transducer activity • coreceptor activity • signaling receptor activity • amylin receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • adrenomedullin receptor activity • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of protein localization to plasma membrane • protein localization • regulation of localization • cellular localization • regulation of protein localization • cellular macromolecule localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • establishment of protein localization • nitrogen compound transport • protein transport • regulation of signaling receptor activity • negative regulation of molecular function • regulation of molecular function • cross-receptor inhibition within G protein-coupled receptor heterodimer • negative regulation of signaling receptor activity • regulation of G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of receptor recycling • receptor recycling • receptor metabolic process • positive regulation of receptor recycling • response to amyloid-beta • heart process • circulatory system process • G protein-coupled receptor signaling pathway involved in heart process • intracellular transport • establishment of localization in cell • intracellular protein transport • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • amylin receptor signaling pathway • response to estradiol • cellular response to estradiol stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • cell surface • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex • amylin receptor complex 3 • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • regulation of heart contraction • regulation of system process • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • regulation of blood circulation • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • protein phosphorylation • phosphorylation • primary metabolic process • macromolecule modification • phosphate-containing compound metabolic process • protein metabolic process • protein modification process • phosphorus metabolic process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • regulation of systemic arterial blood pressure • regulation of blood pressure • behavior • feeding behavior • negative regulation of blood pressure • calcitonin receptor activity • calcitonin family binding • adrenomedullin binding • peptide hormone binding • hormone binding • calcitonin gene-related peptide receptor activity • heart development • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • response to disaccharide • cellular response to sucrose stimulus • cellular response to carbohydrate stimulus • response to carbohydrate • response to sucrose • cellular response to disaccharide stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • endosome • intracellular vesicle • cytoplasmic vesicle • CGRP receptor complex • endoplasmic reticulum
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>6UVA_nogp_Chain_E M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q16602
Sequence	>6UVA_nogp_Chain_R G V T R N K I M T A Q Y E C Y Q K I M Q Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D N W F R H P A S N R T W T N Y T Q C N V N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F K S L S C Q R I T L H K N L F F S F V C N S V V T I I H L T A V A N N Q A L V A T N P V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V A V F A E K Q H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y N D N C W I S S D T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K V T N L Y M K A V R A T L I L V P L L G I E F V L I P W E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E V Q A I L R R N W N Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	10.1021/acsptsci.9b00080

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