psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	11.67	Yes	No	1	0	9
2	L:L:?1	R:R:Y104	16.13	Yes	Yes	1	0	8
3	L:L:?1	R:R:S107	12.91	Yes	No	0	0	8
4	L:L:?1	R:R:W400	9.8	Yes	Yes	1	0	9
5	L:L:?1	R:R:Y403	11.09	Yes	Yes	1	0	8
6	L:L:?1	R:R:Y426	8.07	Yes	Yes	1	0	7
7	L:L:?1	R:R:C429	4.09	Yes	No	1	0	8
8	R:R:F25	R:R:V24	7.87	No	No	0	3	6
9	R:R:V27	R:R:V85	4.81	No	No	0	5	6
10	R:R:M77	R:R:S34	6.13	Yes	No	0	9	8
11	R:R:N78	R:R:S34	5.96	No	No	0	9	8
12	R:R:G73	R:R:T37	3.64	No	No	1	8	8
13	R:R:M77	R:R:T37	9.03	Yes	No	1	9	8
14	R:R:T37	R:R:T434	10.99	No	No	0	8	7
15	R:R:G40	R:R:I39	3.53	No	No	0	9	5
16	R:R:N41	R:R:V44	7.39	No	No	3	9	9
17	R:R:A66	R:R:N41	4.69	No	No	3	9	9
18	R:R:L70	R:R:N41	10.98	No	No	0	8	9
19	R:R:A66	R:R:V44	3.39	No	No	3	9	9
20	R:R:F63	R:R:M45	7.46	No	No	0	7	7
21	R:R:V46	R:R:V50	3.21	No	No	0	6	7
22	R:R:S47	R:R:T450	3.2	No	No	0	9	8
23	R:R:I48	R:R:Q55	6.86	No	No	0	8	8
24	R:R:F63	R:R:I48	10.05	No	No	0	7	8
25	R:R:L54	R:R:N51	4.12	Yes	No	4	9	8
26	R:R:N51	R:R:T450	7.31	No	No	4	8	8
27	R:R:L54	R:R:T446	5.9	Yes	No	0	9	7
28	R:R:F447	R:R:L54	17.05	Yes	Yes	0	9	9
29	R:R:L54	R:R:T450	5.9	Yes	No	4	9	8
30	R:R:Q55	R:R:Y60	3.38	No	No	0	8	8
31	R:R:N59	R:R:T56	8.77	No	No	0	9	8
32	R:R:D120	R:R:N58	5.39	Yes	No	2	9	9
33	R:R:N58	R:R:R135	6.03	No	Yes	2	9	8
34	R:R:F61	R:R:I116	3.77	Yes	No	0	8	8
35	R:R:F61	R:R:M143	3.73	Yes	No	0	8	8
36	R:R:F61	R:R:I144	7.54	Yes	No	0	8	9
37	R:R:L62	R:R:Y440	3.52	No	Yes	0	8	9
38	R:R:N113	R:R:S64	8.94	No	No	0	9	9
39	R:R:I144	R:R:S64	9.29	No	No	0	9	9
40	R:R:D69	R:R:L65	8.14	No	No	1	9	9
41	R:R:L65	R:R:N113	4.12	No	No	0	9	9
42	R:R:L65	R:R:N436	4.12	No	Yes	1	9	9
43	R:R:D69	R:R:S433	8.83	No	No	0	9	9
44	R:R:D69	R:R:N436	6.73	No	Yes	1	9	9
45	R:R:I71	R:R:L102	4.28	No	No	0	8	6
46	R:R:I72	R:R:S76	4.64	No	Yes	1	8	8
47	R:R:I72	R:R:Y430	8.46	No	Yes	1	8	9
48	R:R:I72	R:R:S433	4.64	No	No	0	8	9
49	R:R:G73	R:R:M77	6.99	No	Yes	1	8	9
50	R:R:F75	R:R:V74	9.18	No	No	0	5	5
51	R:R:F75	R:R:L102	4.87	No	No	0	5	6
52	R:R:S76	R:R:W99	4.94	Yes	Yes	0	8	7
53	R:R:D103	R:R:S76	4.42	No	Yes	1	9	8
54	R:R:S76	R:R:Y430	10.17	Yes	Yes	1	8	9
55	R:R:M77	R:R:W427	3.49	Yes	Yes	1	9	9
56	R:R:M77	R:R:Y430	8.38	Yes	Yes	1	9	9
57	R:R:L79	R:R:W99	5.69	No	Yes	0	7	7
58	R:R:Y80	R:R:Y83	6.95	Yes	Yes	1	8	7
59	R:R:W99	R:R:Y80	3.86	Yes	Yes	0	7	8
60	R:R:Y426	R:R:Y80	13.9	Yes	Yes	1	7	8
61	R:R:W427	R:R:Y80	4.82	Yes	Yes	1	9	8
62	R:R:Y80	W:W:?1	7.76	Yes	Yes	1	8	0
63	R:R:T81	R:R:W427	3.64	No	Yes	0	7	9
64	R:R:I86	R:R:L82	7.14	Yes	No	0	6	5
65	R:R:W89	R:R:Y83	8.68	Yes	Yes	1	9	7
66	R:R:E175	R:R:Y83	6.73	No	Yes	1	5	7
67	R:R:Y83	W:W:?1	6.89	Yes	Yes	1	7	0
68	R:R:I86	R:R:Y88	3.63	Yes	No	6	6	4
69	R:R:I86	R:R:P90	5.08	Yes	No	6	6	4
70	R:R:P90	R:R:Y88	11.13	No	No	6	4	4
71	R:R:L91	R:R:W89	5.69	No	Yes	1	8	9
72	R:R:C96	R:R:W89	6.53	No	Yes	1	9	9
73	R:R:W89	R:R:W99	11.25	Yes	Yes	0	9	7
74	R:R:C176	R:R:W89	3.92	No	Yes	1	9	9
75	R:R:G92	R:R:L91	3.42	No	No	1	7	8
76	R:R:L91	R:R:V95	4.47	No	No	1	8	6
77	R:R:G92	R:R:P93	4.06	No	No	0	7	4
78	R:R:G92	R:R:V95	3.68	No	No	1	7	6
79	R:R:D173	R:R:P93	6.44	No	No	0	3	4
80	R:R:C96	R:R:L100	3.17	No	No	0	9	7
81	R:R:C176	R:R:C96	7.28	No	No	1	9	9
82	R:R:L100	R:R:W99	3.42	No	Yes	0	7	7
83	R:R:L102	R:R:V106	4.47	No	No	0	6	7
84	R:R:D103	R:R:Y430	3.45	No	Yes	1	9	9
85	R:R:W155	R:R:Y104	13.5	Yes	Yes	0	8	8
86	R:R:I159	R:R:Y104	4.84	No	Yes	0	8	8
87	R:R:Y104	R:R:Y403	5.96	Yes	Yes	1	8	8
88	R:R:F152	R:R:V105	3.93	No	No	0	5	8
89	R:R:M112	R:R:N108	5.61	No	No	0	8	9
90	R:R:N108	R:R:S151	7.45	No	No	0	9	9
91	R:R:N108	R:R:W155	7.91	No	Yes	0	9	8
92	R:R:A109	R:R:W148	7.78	No	No	0	8	9
93	R:R:P198	R:R:V111	3.53	No	Yes	0	9	9
94	R:R:F396	R:R:V111	5.24	No	Yes	0	9	9
95	R:R:V111	R:R:W400	4.9	Yes	Yes	0	9	9
96	R:R:L114	R:R:N436	4.12	No	Yes	0	9	9
97	R:R:L114	R:R:Y440	8.21	No	Yes	0	9	9
98	R:R:F119	R:R:L115	7.31	No	No	0	7	7
99	R:R:L115	R:R:P198	6.57	No	No	0	7	9
100	R:R:I117	R:R:R121	7.52	No	No	5	9	9
101	R:R:I117	R:R:Y440	6.04	No	Yes	5	9	9
102	R:R:L205	R:R:S118	6.01	No	No	0	8	9
103	R:R:S118	R:R:Y206	6.36	No	Yes	0	9	9
104	R:R:F119	R:R:I201	3.77	No	No	0	7	7
105	R:R:F119	R:R:L205	6.09	No	No	0	7	8
106	R:R:C124	R:R:D120	4.67	No	Yes	2	8	9
107	R:R:D120	R:R:Y131	10.34	Yes	Yes	2	9	9
108	R:R:D120	R:R:R135	13.1	Yes	Yes	2	9	8
109	R:R:R121	R:R:Y206	8.23	No	Yes	0	9	9
110	R:R:R121	R:R:Y440	6.17	No	Yes	5	9	9
111	R:R:T126	R:R:Y122	7.49	No	Yes	0	8	9
112	R:R:L205	R:R:Y122	5.86	No	Yes	0	8	9
113	R:R:H208	R:R:Y122	7.62	No	Yes	0	6	9
114	R:R:I209	R:R:Y122	6.04	No	Yes	0	9	9
115	R:R:F123	R:R:Y131	14.44	No	Yes	0	6	9
116	R:R:C124	R:R:Y131	4.03	No	Yes	2	8	9
117	R:R:T126	R:R:V125	3.17	No	No	0	8	8
118	R:R:P132	R:R:Y131	4.17	No	Yes	0	7	9
119	R:R:K134	R:R:Y131	3.58	No	Yes	0	6	9
120	R:R:R135	R:R:Y131	11.32	Yes	Yes	2	8	9
121	R:R:F152	R:R:I153	5.02	No	No	0	5	5
122	R:R:T190	R:R:W155	8.49	No	Yes	0	9	8
123	R:R:A156	R:R:P157	3.74	No	No	0	6	8
124	R:R:I159	R:R:I178	4.42	No	No	0	8	7
125	R:R:F161	R:R:F164	4.29	No	No	0	7	6
126	R:R:I165	R:R:W162	8.22	No	Yes	0	5	6
127	R:R:V166	R:R:W162	4.9	No	Yes	0	4	6
128	R:R:F180	R:R:W162	17.04	No	Yes	8	7	6
129	R:R:N183	R:R:W162	9.04	No	Yes	0	7	6
130	R:R:A184	R:R:W162	3.89	No	Yes	0	4	6
131	R:R:V186	R:R:W162	4.9	No	Yes	8	8	6
132	R:R:F164	R:R:Q163	16.4	No	Yes	7	6	7
133	R:R:Q163	R:R:R169	9.35	Yes	No	7	7	8
134	R:R:Q163	R:R:Q179	6.4	Yes	No	0	7	7
135	R:R:F164	R:R:R169	4.28	No	No	7	6	8
136	R:R:V171	R:R:Y177	12.62	No	No	0	4	4
137	R:R:E175	W:W:?1	6.82	No	Yes	1	5	0
138	R:R:Y177	W:W:?1	8.62	No	Yes	0	4	0
139	R:R:F180	R:R:I178	13.82	No	No	0	7	7
140	R:R:F180	R:R:V186	3.93	No	No	8	7	8
141	R:R:F181	R:R:S182	7.93	No	No	0	5	6
142	R:R:F181	W:W:?1	10.75	No	Yes	0	5	0
143	R:R:S182	R:R:T411	3.2	No	No	0	6	7
144	R:R:F188	R:R:T187	9.08	No	No	0	7	8
145	R:R:T187	R:R:T411	14.13	No	No	0	8	7
146	R:R:F188	R:R:L408	7.31	No	No	0	7	7
147	R:R:A191	R:R:L408	3.15	No	No	0	8	7
148	R:R:F195	R:R:Y196	5.16	Yes	No	0	9	8
149	R:R:F195	R:R:F396	5.36	Yes	No	0	9	9
150	R:R:F195	R:R:I397	3.77	Yes	No	0	9	7
151	R:R:F195	R:R:W400	5.01	Yes	Yes	0	9	9
152	R:R:F195	R:R:N404	16.92	Yes	No	0	9	7
153	R:R:L197	R:R:P198	4.93	No	No	0	7	9
154	R:R:I201	R:R:L197	4.28	No	No	0	7	7
155	R:R:L393	R:R:M202	4.24	No	No	0	8	9
156	R:R:I389	R:R:Y206	9.67	No	Yes	0	9	9
157	R:R:L393	R:R:Y206	3.52	No	Yes	0	8	9
158	R:R:H208	R:R:W207	8.46	No	No	0	6	4
159	R:R:R211	R:R:W207	6	No	No	0	5	4
160	R:R:S210	R:R:T386	4.8	No	Yes	0	8	8
161	R:R:E382	R:R:K214	4.05	Yes	No	0	9	7
162	R:R:K384	R:R:P379	6.69	No	No	0	9	4
163	R:R:I392	R:R:Y440	6.04	No	Yes	0	9	9
164	R:R:F396	R:R:N432	3.62	No	Yes	0	9	9
165	R:R:T399	R:R:W400	6.06	No	Yes	1	9	9
166	R:R:N432	R:R:T399	13.16	Yes	No	1	9	9
167	R:R:C429	R:R:W400	3.92	No	Yes	1	8	9
168	R:R:N432	R:R:W400	9.04	Yes	Yes	1	9	9
169	R:R:L428	R:R:P402	8.21	No	No	0	8	9
170	R:R:N404	R:R:Y403	6.98	No	Yes	0	7	8
171	R:R:V407	R:R:Y403	6.31	No	Yes	0	8	8
172	R:R:W422	R:R:Y403	8.68	Yes	Yes	1	6	8
173	R:R:G425	R:R:M406	3.49	No	No	0	6	7
174	R:R:I417	R:R:N410	16.99	Yes	No	1	7	4
175	R:R:N410	R:R:W422	4.52	No	Yes	1	4	6
176	R:R:N410	W:W:?1	7.07	No	Yes	1	4	0
177	R:R:I417	R:R:W422	4.7	Yes	Yes	1	7	6
178	R:R:I417	W:W:?1	4.2	Yes	Yes	1	7	0
179	R:R:P418	R:R:T420	5.25	No	No	0	7	4
180	R:R:P418	R:R:V421	3.53	No	No	0	7	5
181	R:R:W422	R:R:Y426	10.61	Yes	Yes	1	6	7
182	R:R:W422	W:W:?1	51.08	Yes	Yes	1	6	0
183	R:R:T423	W:W:?1	4.33	No	Yes	0	6	0
184	R:R:Y426	R:R:Y430	6.95	Yes	Yes	1	7	9
185	R:R:Y426	W:W:?1	6.03	Yes	Yes	1	7	0
186	R:R:W427	R:R:Y430	5.79	Yes	Yes	1	9	9
187	R:R:N432	R:R:N436	5.45	Yes	Yes	1	9	9
188	R:R:C439	R:R:I435	3.27	No	No	0	9	6
189	R:R:N444	R:R:T446	10.24	No	No	0	9	7
190	R:R:F447	R:R:N444	10.87	Yes	No	0	9	9
191	R:R:T423	R:R:T84	3.14	No	No	0	6	7
192	R:R:I417	R:R:V421	3.07	Yes	No	0	7	5
193	R:R:I424	R:R:V421	3.07	No	No	0	5	5
194	R:R:I392	R:R:T388	3.04	No	No	0	9	9
195	R:R:L43	R:R:S47	3	No	No	0	8	9
196	R:R:N78	R:R:V74	2.96	No	No	0	9	5
197	R:R:I417	R:R:M406	2.92	Yes	No	0	7	7
198	R:R:Q179	R:R:V171	2.87	No	No	0	7	4
199	R:R:E382	R:R:S213	2.87	Yes	No	0	9	8
200	R:R:I435	R:R:N432	2.83	No	Yes	0	6	9
201	R:R:C67	R:R:F63	2.79	No	No	0	7	7
202	R:R:A140	R:R:F61	2.77	No	Yes	0	8	8
203	R:R:A156	R:R:F152	2.77	No	No	0	6	5
204	R:R:H208	R:R:V204	2.77	No	No	0	6	5
205	R:R:A441	R:R:F447	2.77	No	Yes	0	8	9
206	L:L:?1	R:R:A194	2.71	Yes	No	0	0	8
207	R:R:A68	R:R:W148	2.59	No	No	0	9	9
208	R:R:M139	R:R:R135	2.48	No	Yes	0	8	8
209	R:R:F447	R:R:N59	2.42	Yes	No	0	9	9
210	R:R:I192	R:R:Y196	2.42	No	No	0	7	8
211	R:R:I144	R:R:W148	2.35	No	No	0	9	9
212	R:R:D173	R:R:Y88	2.3	No	No	0	3	4
213	R:R:L154	R:R:W155	2.28	No	Yes	0	8	8
214	R:R:N419	W:W:?1	2.02	No	Yes	0	4	0
215	R:R:A140	R:R:G141	1.95	No	No	0	8	4
216	R:R:A401	R:R:P402	1.87	No	No	0	7	9
217	R:R:G31	R:R:S34	1.86	No	No	0	4	8
218	R:R:G167	R:R:V166	1.84	No	No	0	5	4
219	R:R:A395	R:R:C439	1.81	No	No	0	8	9
220	R:R:P437	R:R:V44	1.77	No	No	0	9	9
221	R:R:G73	R:R:I38	1.76	No	No	0	8	7
222	R:R:G87	R:R:I86	1.76	No	Yes	0	6	6
223	R:R:G189	R:R:I192	1.76	No	No	0	6	7
224	R:R:G40	R:R:L43	1.71	No	No	0	9	8
225	R:R:A212	R:R:V125	1.7	No	No	0	7	8
226	R:R:A30	R:R:T81	1.68	No	No	0	7	7
227	R:R:M406	R:R:P402	1.68	No	No	0	7	9
228	R:R:K127	R:R:P128	1.67	No	No	0	7	9
229	R:R:E175	R:R:G174	1.64	No	No	0	5	3
230	R:R:N436	R:R:P437	1.63	Yes	No	0	9	9
231	R:R:A30	R:R:I26	1.62	No	No	0	7	6
232	R:R:S32	R:R:V36	1.62	No	No	0	5	5
233	R:R:S110	R:R:V111	1.62	No	Yes	0	9	9
234	R:R:A147	R:R:I116	1.62	No	No	0	8	8
235	R:R:A445	R:R:K448	1.61	No	No	0	5	9
236	R:R:T170	R:R:V166	1.59	No	No	0	5	4
237	R:R:T170	R:R:V171	1.59	No	No	0	5	4
238	R:R:T203	R:R:V199	1.59	No	No	0	6	7
239	R:R:A438	R:R:L442	1.58	No	No	0	7	7
240	R:R:T136	R:R:T137	1.57	No	No	0	9	5
241	R:R:I26	R:R:V23	1.54	No	No	0	6	4
242	R:R:I26	R:R:V27	1.54	No	No	0	6	5
243	R:R:I42	R:R:V46	1.54	No	No	0	6	6
244	R:R:I86	R:R:V85	1.54	Yes	No	0	6	6
245	R:R:I153	R:R:V149	1.54	No	No	0	5	5
246	R:R:I200	R:R:V199	1.54	No	No	0	5	7
247	R:R:I397	R:R:V199	1.54	No	No	0	7	7
248	R:R:I389	R:R:V385	1.54	No	No	0	9	8
249	R:R:K383	R:R:T386	1.5	No	Yes	0	7	8
250	R:R:I39	R:R:I42	1.47	No	No	0	5	6
251	R:R:L129	R:R:T130	1.47	No	No	0	7	6
252	R:R:L390	R:R:T386	1.47	No	Yes	0	7	8
253	R:R:I397	R:R:I398	1.47	No	No	0	7	5
254	R:R:I431	R:R:I435	1.47	No	No	0	6	6
255	R:R:N58	R:R:T56	1.46	No	No	0	9	8
256	R:R:M139	R:R:M143	1.44	No	No	0	8	8
257	R:R:E382	R:R:S380	1.44	Yes	No	0	9	5
258	R:R:I38	R:R:L35	1.43	No	No	0	7	6
259	R:R:I48	R:R:N59	1.42	No	No	0	8	9
260	R:R:L150	R:R:M112	1.41	No	No	0	6	8
261	R:R:E382	R:R:T386	1.41	Yes	Yes	0	9	8
262	R:R:A185	R:R:F188	1.39	No	No	0	4	7
263	R:R:R381	R:R:S213	1.32	No	No	0	7	8
264	R:R:R381	R:R:S215	1.32	No	No	0	7	6
265	R:R:F25	R:R:V29	1.31	No	No	0	3	4
266	R:R:D97	R:R:Q163	1.31	No	Yes	0	7	7
267	R:R:H53	R:R:N51	1.28	No	No	0	6	8
268	R:R:K384	R:R:R387	1.24	No	No	0	9	8
269	R:R:K127	R:R:Y131	1.19	No	Yes	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.55875	8	1	0
2	R:R:L54	8.2425	4	4	9
3	R:R:F61	4.4525	4	0	8
4	R:R:S76	6.0425	4	1	8
5	R:R:M77	6.804	5	1	9
6	R:R:Y80	7.458	5	1	8
7	R:R:Y83	7.3125	4	1	7
8	R:R:I86	3.83	5	6	6
9	R:R:W89	7.214	5	1	9
10	R:R:W99	5.832	5	0	7
11	R:R:Y104	10.1075	4	1	8
12	R:R:V111	3.8225	4	0	9
13	R:R:D120	8.375	4	2	9
14	R:R:Y122	6.7525	4	0	9
15	R:R:Y131	7.01	7	2	9
16	R:R:R135	8.2325	4	2	8
17	R:R:W155	8.045	4	0	8
18	R:R:W162	7.99833	6	8	6
19	R:R:Q163	8.365	4	7	7
20	R:R:F195	7.244	5	0	9
21	R:R:Y206	6.945	4	0	9
22	R:R:E382	2.4425	4	0	9
23	R:R:T386	2.295	4	0	8
24	R:R:W400	6.455	6	1	9
25	R:R:Y403	7.804	5	1	8
26	R:R:I417	6.376	5	1	7
27	R:R:W422	15.918	5	1	6
28	R:R:Y426	9.112	5	1	7
29	R:R:W427	4.435	4	1	9
30	R:R:Y430	7.2	6	1	9
31	R:R:N432	6.82	5	1	9
32	R:R:N436	4.41	5	1	9
33	R:R:Y440	5.996	5	5	9
34	R:R:F447	8.2775	4	0	9
35	W:W:?1	10.5064	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	20.5102	11.67	Yes	No	1	0	9
2	R:R:D103	R:R:Y430	13.2924	3.45	No	Yes	1	9	9
3	R:R:W427	R:R:Y430	16.8313	5.79	Yes	Yes	1	9	9
4	R:R:T81	R:R:W427	24.2669	3.64	No	Yes	0	7	9
5	R:R:A30	R:R:T81	21.8791	1.68	No	No	0	7	7
6	R:R:A30	R:R:I26	19.6002	1.62	No	No	0	7	6
7	R:R:I26	R:R:V27	14.6068	1.54	No	No	0	6	5
8	L:L:?1	R:R:Y426	74.3875	8.07	Yes	Yes	1	0	7
9	R:R:Y426	R:R:Y430	40.9505	6.95	Yes	Yes	1	7	9
10	R:R:Y426	R:R:Y80	17.8113	13.9	Yes	Yes	1	7	8
11	R:R:W427	R:R:Y80	17.2046	4.82	Yes	Yes	1	9	8
12	R:R:V27	R:R:V85	12.1257	4.81	No	No	0	5	6
13	R:R:M77	R:R:Y430	28.5214	8.38	Yes	Yes	1	9	9
14	R:R:M77	R:R:S34	21.3969	6.13	Yes	No	0	9	8
15	R:R:N78	R:R:S34	16.1391	5.96	No	No	0	9	8
16	L:L:?1	R:R:W400	100	9.8	Yes	Yes	1	0	9
17	R:R:N432	R:R:W400	65.3496	9.04	Yes	Yes	1	9	9
18	R:R:N432	R:R:N436	67.6985	5.45	Yes	Yes	1	9	9
19	R:R:L65	R:R:N436	60.7218	4.12	No	Yes	1	9	9
20	R:R:L65	R:R:N113	98.0866	4.12	No	No	0	9	9
21	R:R:N113	R:R:S64	96.3988	8.94	No	No	0	9	9
22	R:R:I144	R:R:S64	94.6955	9.29	No	No	0	9	9
23	R:R:F61	R:R:I144	87.7265	7.54	Yes	No	0	8	9
24	R:R:F61	R:R:M143	78.642	3.73	Yes	No	0	8	8
25	R:R:M139	R:R:M143	76.7908	1.44	No	No	0	8	8
26	R:R:M139	R:R:R135	74.9164	2.48	No	Yes	0	8	8
27	R:R:N58	R:R:R135	54.9584	6.03	No	Yes	2	9	8
28	R:R:N58	R:R:T56	54.4295	1.46	No	No	0	9	8
29	R:R:N59	R:R:T56	52.3295	8.77	No	No	0	9	8
30	R:R:F447	R:R:N59	37.186	2.42	Yes	No	0	9	9
31	R:R:F447	R:R:L54	28.3581	17.05	Yes	Yes	0	9	9
32	R:R:L54	R:R:T450	19.0947	5.9	Yes	No	4	9	8
33	R:R:S47	R:R:T450	16.8702	3.2	No	No	0	9	8
34	R:R:L43	R:R:S47	14.5057	3	No	No	0	8	9
35	R:R:G40	R:R:L43	12.1257	1.71	No	No	0	9	8
36	R:R:I48	R:R:N59	14.4902	1.42	No	No	0	8	9
37	R:R:L114	R:R:N436	25.3247	4.12	No	Yes	0	9	9
38	R:R:L114	R:R:Y440	23.6914	8.21	No	Yes	0	9	9
39	R:R:I72	R:R:S76	10.3757	4.64	No	Yes	1	8	8
40	R:R:I72	R:R:S433	46.6438	4.64	No	No	0	8	9
41	R:R:I72	R:R:Y430	37.606	8.46	No	Yes	1	8	9
42	R:R:N78	R:R:V74	13.4868	2.96	No	No	0	9	5
43	R:R:F75	R:R:V74	10.819	9.18	No	No	0	5	5
44	R:R:S76	R:R:W99	16.5124	4.94	Yes	Yes	0	8	7
45	R:R:Y426	W:W:?1	56.2806	6.03	Yes	Yes	1	7	0
46	R:R:Y83	W:W:?1	11.8457	6.89	Yes	Yes	1	7	0
47	R:R:W89	R:R:W99	16.6602	11.25	Yes	Yes	0	9	7
48	R:R:W89	R:R:Y83	16.3413	8.68	Yes	Yes	1	9	7
49	R:R:L91	R:R:W89	22.8591	5.69	No	Yes	1	8	9
50	R:R:G92	R:R:L91	16.4969	3.42	No	No	1	7	8
51	R:R:G92	R:R:P93	13.4713	4.06	No	No	0	7	4
52	R:R:D173	R:R:P93	10.3601	6.44	No	No	0	3	4
53	L:L:?1	R:R:Y104	28.8948	16.13	Yes	Yes	1	0	8
54	R:R:W155	R:R:Y104	17.5158	13.5	Yes	Yes	0	8	8
55	R:R:I159	R:R:Y104	15.8124	4.84	No	Yes	0	8	8
56	R:R:N108	R:R:W155	10.2279	7.91	No	Yes	0	9	8
57	R:R:V111	R:R:W400	35.3037	4.9	Yes	Yes	0	9	9
58	R:R:P198	R:R:V111	34.1837	3.53	No	Yes	0	9	9
59	R:R:F195	R:R:W400	20.2847	5.01	Yes	Yes	0	9	9
60	R:R:F396	R:R:N432	11.5968	3.62	No	Yes	0	9	9
61	R:R:L115	R:R:P198	25.9236	6.57	No	No	0	7	9
62	R:R:F119	R:R:L115	23.3336	7.31	No	No	0	7	7
63	R:R:R121	R:R:Y440	15.7268	6.17	No	Yes	5	9	9
64	R:R:F119	R:R:L205	21.0936	6.09	No	No	0	7	8
65	R:R:R121	R:R:Y206	14.4279	8.23	No	Yes	0	9	9
66	R:R:R135	R:R:Y131	16.2946	11.32	Yes	Yes	2	8	9
67	R:R:L205	R:R:Y122	21.9491	5.86	No	Yes	0	8	9
68	R:R:I159	R:R:I178	13.6968	4.42	No	No	0	8	7
69	R:R:Y177	W:W:?1	26.5614	8.62	No	Yes	0	4	0
70	R:R:V171	R:R:Y177	24.5081	12.62	No	No	0	4	4
71	R:R:Q179	R:R:V171	13.4713	2.87	No	No	0	7	4
72	R:R:Q163	R:R:Q179	11.239	6.4	Yes	No	0	7	7
73	R:R:F180	R:R:I178	11.6824	13.82	No	No	0	7	7
74	R:R:F181	W:W:?1	17.928	10.75	No	Yes	0	5	0
75	R:R:F181	R:R:S182	15.9446	7.93	No	No	0	5	6
76	R:R:S182	R:R:T411	13.7124	3.2	No	No	0	6	7
77	R:R:T187	R:R:T411	11.4646	14.13	No	No	0	8	7
78	R:R:F195	R:R:Y196	10.0023	5.16	Yes	No	0	9	8
79	R:R:F195	R:R:I397	16.598	3.77	Yes	No	0	9	7
80	L:L:?1	R:R:Y403	12.2501	11.09	Yes	Yes	1	0	8
81	R:R:W422	R:R:Y403	18.838	8.68	Yes	Yes	1	6	8
82	R:R:I417	R:R:W422	22.548	4.7	Yes	Yes	1	7	6
83	R:R:I417	R:R:M406	20.8369	2.92	Yes	No	0	7	7
84	R:R:M406	R:R:P402	12.5457	1.68	No	No	0	7	9
85	R:R:W422	R:R:Y426	16.668	10.61	Yes	Yes	1	6	7
86	R:R:I417	W:W:?1	18.6591	4.2	Yes	Yes	1	7	0
87	R:R:I417	R:R:V421	16.6991	3.07	Yes	No	0	7	5
88	R:R:I435	R:R:N432	10.259	2.83	No	Yes	0	6	9
89	R:R:I397	R:R:V199	10.0023	1.54	No	No	0	7	7
90	R:R:D69	R:R:S433	46.2161	8.83	No	No	0	9	9
91	R:R:D69	R:R:L65	39.0293	8.14	No	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	11.67	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y104	16.13	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S107	12.91	1	Yes	No	0	8	0	1
L:L:?1	R:R:W400	9.8	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y403	11.09	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y426	8.07	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C429	4.09	1	Yes	No	0	8	0	1
R:R:D103	R:R:S76	4.42	1	No	Yes	9	8	1	2
R:R:S76	R:R:Y430	10.17	1	Yes	Yes	8	9	2	2
R:R:Y426	R:R:Y80	13.9	1	Yes	Yes	7	8	1	2
R:R:Y80	W:W:?1	7.76	1	Yes	Yes	8	0	2	2
R:R:D103	R:R:Y430	3.45	1	No	Yes	9	9	1	2
R:R:W155	R:R:Y104	13.5	0	Yes	Yes	8	8	2	1
R:R:I159	R:R:Y104	4.84	0	No	Yes	8	8	2	1
R:R:Y104	R:R:Y403	5.96	1	Yes	Yes	8	8	1	1
R:R:V111	R:R:W400	4.9	0	Yes	Yes	9	9	2	1
R:R:F195	R:R:W400	5.01	0	Yes	Yes	9	9	2	1
R:R:F195	R:R:N404	16.92	0	Yes	No	9	7	2	2
R:R:T399	R:R:W400	6.06	1	No	Yes	9	9	2	1
R:R:N432	R:R:T399	13.16	1	Yes	No	9	9	2	2
R:R:C429	R:R:W400	3.92	1	No	Yes	8	9	1	1
R:R:N432	R:R:W400	9.04	1	Yes	Yes	9	9	2	1
R:R:N404	R:R:Y403	6.98	0	No	Yes	7	8	2	1
R:R:V407	R:R:Y403	6.31	0	No	Yes	8	8	2	1
R:R:W422	R:R:Y403	8.68	1	Yes	Yes	6	8	2	1
R:R:W422	R:R:Y426	10.61	1	Yes	Yes	6	7	2	1
R:R:W422	W:W:?1	51.08	1	Yes	Yes	6	0	2	2
R:R:Y426	R:R:Y430	6.95	1	Yes	Yes	7	9	1	2
R:R:Y426	W:W:?1	6.03	1	Yes	Yes	7	0	1	2
L:L:?1	R:R:A194	2.71	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y403	11.09	1	Yes	Yes	0	8	2	2
L:L:?1	R:R:Y426	8.07	1	Yes	Yes	0	7	2	1
R:R:Y80	R:R:Y83	6.95	1	Yes	Yes	8	7	1	1
R:R:W99	R:R:Y80	3.86	0	Yes	Yes	7	8	2	1
R:R:Y426	R:R:Y80	13.9	1	Yes	Yes	7	8	1	1
R:R:W427	R:R:Y80	4.82	1	Yes	Yes	9	8	2	1
R:R:Y80	W:W:?1	7.76	1	Yes	Yes	8	0	1	0
R:R:W89	R:R:Y83	8.68	1	Yes	Yes	9	7	2	1
R:R:E175	R:R:Y83	6.73	1	No	Yes	5	7	1	1
R:R:Y83	W:W:?1	6.89	1	Yes	Yes	7	0	1	0
R:R:W89	R:R:W99	11.25	1	Yes	Yes	9	7	2	2
R:R:V171	R:R:Y177	12.62	0	No	No	4	4	2	1
R:R:E175	W:W:?1	6.82	1	No	Yes	5	0	1	0
R:R:Y177	W:W:?1	8.62	0	No	Yes	4	0	1	0
R:R:F181	R:R:S182	7.93	0	No	No	5	6	1	2
R:R:F181	W:W:?1	10.75	0	No	Yes	5	0	1	0
R:R:W422	R:R:Y403	8.68	1	Yes	Yes	6	8	1	2
R:R:I417	R:R:N410	16.99	1	Yes	No	7	4	1	1
R:R:N410	R:R:W422	4.52	1	No	Yes	4	6	1	1
R:R:N410	W:W:?1	7.07	1	No	Yes	4	0	1	0
R:R:I417	R:R:W422	4.7	1	Yes	Yes	7	6	1	1
R:R:I417	W:W:?1	4.2	1	Yes	Yes	7	0	1	0
R:R:W422	R:R:Y426	10.61	1	Yes	Yes	6	7	1	1
R:R:W422	W:W:?1	51.08	1	Yes	Yes	6	0	1	0
R:R:T423	W:W:?1	4.33	0	No	Yes	6	0	1	0
R:R:Y426	R:R:Y430	6.95	1	Yes	Yes	7	9	1	2
R:R:Y426	W:W:?1	6.03	1	Yes	Yes	7	0	1	0
R:R:W427	R:R:Y430	5.79	1	Yes	Yes	9	9	2	2
R:R:T423	R:R:T84	3.14	0	No	No	6	7	1	2
R:R:I417	R:R:V421	3.07	1	Yes	No	7	5	1	2
R:R:I417	R:R:M406	2.92	1	Yes	No	7	7	1	2
R:R:N419	W:W:?1	2.02	0	No	Yes	4	0	1	0
R:R:E175	R:R:G174	1.64	1	No	No	5	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T94_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	238
Number of Links	269
Number of Hubs	35
Number of Links mediated by Hubs	138
Number of Communities	8
Number of Nodes involved in Communities	55
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	35253
Length Of Smallest Path	3
Average Path Length	12.8529
Length of Longest Path	34
Minimum Path Strength	1.425
Average Path Strength	6.46636
Maximum Path Strength	30.915
Minimum Path Correlation	0.7
Average Path Correlation	0.92642
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	55.1588
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7392
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • intracellular vesicle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • cytoplasm • organelle membrane • presynapse • somatodendritic compartment • dendrite • dendritic tree • neuron projection • cholinergic synapse • Golgi apparatus • endomembrane system • ciliary basal body • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACH
Name	Acetylcholine
Synonyms	Acetylcholine chloride Acetylcholine ACh O-Acetylcholine Choline acetate
Identifier
Formula	C7 H16 N O2
Molecular Weight	146.207
SMILES
PubChem	187
Formal Charge	1
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	25
Total Aromatic Bonds	0


Code	2CU
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	2CU
Name	3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
Synonyms	LY2119620 positive allosteric modulator of M2/M4 receptor
Identifier
Formula	C19 H24 Cl N5 O3 S
Molecular Weight	437.944
SMILES
PubChem	57664406
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08172
Sequence	>7T94_nogp_Chain_R V V F I V L V A G S L S L V T I I G N I L V M V S I K V N R H L Q T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G Y W P L G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P V K R T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G V R T V E D G E C Y I Q F F S N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F I P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K K T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3UON	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	3	2012-02-01	doi.org/10.1038/nature10753
	4MQS	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	-	-	3.5	2013-11-27	doi.org/10.1038/nature12735
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5YC8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-methyl-Scopolamine	-	-	2.5	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK3	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	3-quinuclidinyl-benzilate	-	-	2.6	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZK8	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-methyl-Scopolamine	-	-	3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKB	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	AF-DX 384	-	-	2.95	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	5ZKC	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	N-methyl-Scopolamine	-	-	2.3	2018-11-21	doi.org/10.1038/s41589-018-0152-y
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7T9N	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC	Gs/β1/γ2	2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7T9N (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	DPPC		2.9	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7XW6	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109	Gs/β1/γ2	2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	7XW6 (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	M22 Fab	ML109		2.78	2022-08-17	doi.org/10.1038/s41586-022-05173-3
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T8X	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T8X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.21	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-	chim(NtGi1-Go)/β1/γ2	3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T90 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	-		3.32	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	9PEE	A	Protein	Chemokine	CCR6	Homo sapiens	-	PF-07054894; OXM2	-	3.35	2025-10-01	doi.org/10.1021/acs.jmedchem.5c01946
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	8PM2	A	Amine	Trace Amine	TA7	Mus musculus	DMCHA	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine	TA7	Mus musculus	DMCHA	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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