Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N59 5.375459
2R:R:F61 5.015408
3R:R:L65 8.2225419
4R:R:D69 8.32519
5R:R:I72 5.795408
6R:R:M77 7.14419
7R:R:Y80 10.0417618
8R:R:I86 4.725406
9R:R:W89 8.71714719
10R:R:W99 10.1425417
11R:R:Y104 8.54125818
12R:R:V106 4.3125407
13R:R:N108 8.64419
14R:R:D120 8.7525429
15R:R:Y122 8.5925409
16R:R:Y131 9.04529
17R:R:R135 12.274528
18R:R:W155 8.11618
19R:R:Q163 7.27407
20R:R:I178 9.786517
21R:R:Q179 7.6075407
22R:R:F180 6.36417
23R:R:F181 6.18415
24R:R:N183 3.7825407
25R:R:F195 9.314519
26R:R:Y196 7.478518
27R:R:Y206 7.93409
28R:R:K214 13.655407
29R:R:F396 6.62419
30R:R:W400 9.83714719
31R:R:Y403 6.78429718
32R:R:N404 9.93417
33R:R:T411 4.705467
34R:R:I417 4.855477
35R:R:Y426 9.725617
36R:R:W427 5.302519
37R:R:Y430 7.05833619
38R:R:N432 9.2725419
39R:R:N436 9.875419
40R:R:Y440 5.776519
41R:R:F447 7.318559
42R:R:F451 7.512539
43L:L:?1 9.368181110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M77 R:R:T37 19.93927.53YesNo098
2R:R:T37 R:R:T434 16.004714.13NoNo087
3R:R:L33 R:R:T434 12.04335.9NoNo067
4R:R:I431 R:R:L33 10.05244.28NoNo066
5R:R:W427 R:R:Y430 13.92943.86YesYes199
6R:R:S76 R:R:Y430 21.27438.9NoYes189
7R:R:I72 R:R:S76 21.8056.19YesNo088
8R:R:I72 R:R:S433 36.36647.74YesNo089
9R:R:D69 R:R:S433 36.32588.83YesNo099
10R:R:D69 R:R:N41 31.27268.08YesNo099
11R:R:N41 R:R:P437 28.08189.77NoNo099
12R:R:P437 R:R:V44 26.47633.53NoNo099
13R:R:F451 R:R:V44 24.85725.24YesNo099
14R:R:F451 R:R:L43 11.840510.96YesNo098
15R:R:I72 R:R:V106 24.53274.61YesYes087
16R:R:I71 R:R:V106 16.636.14NoYes087
17R:R:I71 R:R:L102 15.14284.28NoNo086
18R:R:F75 R:R:L102 13.64883.65NoNo056
19R:R:F75 R:R:V74 12.14810.49NoNo055
20R:R:I38 R:R:V74 10.64054.61NoNo075
21R:R:Y426 R:R:Y80 17.022125.81YesYes178
22L:L:?1 R:R:Y426 28.112210.87YesYes107
23L:L:?1 R:R:W400 66.9918.69YesYes109
24R:R:N432 R:R:W400 75.004214.69YesYes199
25R:R:N432 R:R:N436 73.726612.26YesYes199
26R:R:L114 R:R:N436 78.04295.49NoYes199
27R:R:L114 R:R:Y440 1009.38NoYes199
28R:R:L62 R:R:Y440 21.36894.69NoYes089
29R:R:L62 R:R:N59 19.89525.49NoYes089
30R:R:F447 R:R:N59 10.69126.04YesYes599
31R:R:Y426 R:R:Y430 17.25874.96YesYes179
32R:R:D69 R:R:N436 27.564610.77YesYes199
33R:R:D69 R:R:L65 17.64079.5YesYes199
34R:R:L114 R:R:L65 23.04215.54NoYes199
35R:R:I117 R:R:Y440 49.28176.04NoYes199
36R:R:F61 R:R:I117 48.02773.77YesNo089
37R:R:D120 R:R:F61 32.64158.36YesYes098
38R:R:F61 R:R:I116 10.46813.77YesNo088
39L:L:?1 R:R:S107 16.41035.36YesNo108
40R:R:I72 R:R:S107 17.27564.64YesNo088
41R:R:W99 R:R:Y80 16.66726.75YesYes178
42R:R:W89 R:R:W99 23.755312.18YesYes197
43R:R:L91 R:R:W89 14.66287.97NoYes189
44R:R:L91 R:R:P90 13.24663.28NoNo084
45R:R:P90 R:R:Y88 11.78985.56NoNo044
46R:R:L100 R:R:W99 11.59717.97NoYes177
47R:R:F180 R:R:I178 23.082611.3YesYes177
48R:R:F180 R:R:W162 43.01176.01YesNo076
49R:R:Q179 R:R:W162 32.922110.95YesNo076
50R:R:Q179 R:R:V171 10.5564.3YesNo074
51R:R:I178 R:R:Y104 22.048313.3YesYes178
52R:R:F181 R:R:Y104 22.17684.13YesYes158
53R:R:F180 R:R:F181 23.75875.36YesYes175
54R:R:Q163 R:R:Q179 19.15163.84YesYes077
55R:R:I392 R:R:Y440 38.65133.63NoYes099
56R:R:I392 R:R:Y206 33.09116.04NoYes099
57R:R:D120 R:R:Y131 24.05619.2YesYes299
58R:R:F123 R:R:Y131 20.07779.28NoYes069
59R:R:F123 R:R:Y122 18.573610.32NoYes069
60R:R:F188 R:R:L408 10.13698.53NoNo077
61R:R:L408 R:R:Y196 14.11199.38NoYes078
62R:R:N404 R:R:Y196 19.30374.65YesYes178
63L:L:?1 R:R:N404 16.04538.81YesYes107
64R:R:I389 R:R:Y206 20.033812.09NoYes099
65R:R:I389 R:R:V385 18.5333.07NoNo098
66R:R:K214 R:R:V385 15.51124.55YesNo078
67R:R:E382 R:R:K214 10.92781.35NoYes097
68R:R:W422 R:R:Y426 13.21955.79NoYes167
69R:R:M406 R:R:W422 26.3586.98NoNo076
70R:R:M406 R:R:V421 21.62583.04NoNo075
71R:R:P418 R:R:V421 19.24965.3NoNo075
72R:R:I417 R:R:P418 16.86673.39YesNo077
73R:R:T81 R:R:W427 13.18916.06NoYes079
74R:R:T81 R:R:V27 10.59321.59NoNo075
75R:R:M77 R:R:Y430 24.3847.18YesYes199
76R:R:L100 R:R:Y104 10.30934.69NoYes178
77L:L:?1 R:R:Y104 39.648515.89YesYes108
78R:R:W422 R:R:Y403 15.4913.86NoYes168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I72 R:R:S76 6.19 0 Yes No 8 8 2 2
R:R:I72 R:R:S107 4.64 0 Yes No 8 8 2 1
R:R:D103 R:R:S76 11.78 1 No No 9 8 1 2
R:R:S76 R:R:Y430 8.9 1 No Yes 8 9 2 2
R:R:Y426 R:R:Y80 25.81 1 Yes Yes 7 8 1 2
R:R:Y430 R:R:Y80 5.96 1 Yes Yes 9 8 2 2
R:R:L100 R:R:Y104 4.69 1 No Yes 7 8 2 1
R:R:I178 R:R:L100 7.14 1 Yes No 7 7 2 2
R:R:D103 R:R:Y430 11.49 1 No Yes 9 9 1 2
L:L:?1 R:R:D103 8.71 1 Yes No 0 9 0 1
R:R:W155 R:R:Y104 11.58 1 Yes Yes 8 8 1 1
R:R:I159 R:R:Y104 4.84 1 No Yes 8 8 2 1
R:R:I178 R:R:Y104 13.3 1 Yes Yes 7 8 2 1
R:R:F181 R:R:Y104 4.13 1 Yes Yes 5 8 2 1
R:R:Y104 R:R:Y403 6.95 1 Yes Yes 8 8 1 1
R:R:Y104 R:R:Y426 6.95 1 Yes Yes 8 7 1 1
L:L:?1 R:R:Y104 15.89 1 Yes Yes 0 8 0 1
R:R:S107 R:R:W400 7.41 1 No Yes 8 9 1 1
L:L:?1 R:R:S107 5.36 1 Yes No 0 8 0 1
R:R:M112 R:R:N108 7.01 0 No Yes 8 9 2 1
R:R:N108 R:R:S151 8.94 1 Yes No 9 9 1 2
R:R:N108 R:R:W155 14.69 1 Yes Yes 9 8 1 1
L:L:?1 R:R:N108 3.92 1 Yes Yes 0 9 0 1
R:R:F396 R:R:V111 6.55 1 Yes No 9 9 2 2
R:R:V111 R:R:W400 7.36 1 No Yes 9 9 2 1
R:R:T190 R:R:W155 7.28 0 No Yes 9 8 2 1
R:R:A194 R:R:W155 3.89 1 No Yes 8 8 1 1
L:L:?1 R:R:W155 8.94 1 Yes Yes 0 8 0 1
R:R:I159 R:R:I178 5.89 1 No Yes 8 7 2 2
R:R:F181 R:R:I178 11.3 1 Yes Yes 5 7 2 2
R:R:F181 R:R:V407 3.93 1 Yes No 5 8 2 2
L:L:?1 R:R:A194 5.62 1 Yes No 0 8 0 1
R:R:F195 R:R:Y196 12.38 1 Yes Yes 9 8 2 2
R:R:F195 R:R:F396 5.36 1 Yes Yes 9 9 2 2
R:R:F195 R:R:N404 18.12 1 Yes Yes 9 7 2 1
R:R:N404 R:R:Y196 4.65 1 Yes Yes 7 8 1 2
R:R:F396 R:R:W400 8.02 1 Yes Yes 9 9 2 1
R:R:T399 R:R:W400 4.85 1 No Yes 9 9 2 1
R:R:N432 R:R:T399 7.31 1 Yes No 9 9 2 2
R:R:C429 R:R:W400 7.84 1 No Yes 8 9 1 1
R:R:N432 R:R:W400 14.69 1 Yes Yes 9 9 2 1
L:L:?1 R:R:W400 18.69 1 Yes Yes 0 9 0 1
R:R:N404 R:R:Y403 8.14 1 Yes Yes 7 8 1 1
R:R:V407 R:R:Y403 8.83 0 No Yes 8 8 2 1
R:R:W422 R:R:Y403 3.86 1 No Yes 6 8 2 1
R:R:Y403 R:R:Y426 3.97 1 Yes Yes 8 7 1 1
R:R:C429 R:R:Y403 4.03 1 No Yes 8 8 1 1
L:L:?1 R:R:Y403 11.71 1 Yes Yes 0 8 0 1
L:L:?1 R:R:N404 8.81 1 Yes Yes 0 7 0 1
R:R:W422 R:R:Y426 5.79 1 No Yes 6 7 2 1
R:R:Y426 R:R:Y430 4.96 1 Yes Yes 7 9 1 2
L:L:?1 R:R:Y426 10.87 1 Yes Yes 0 7 0 1
L:L:?1 R:R:C429 4.53 1 Yes No 0 8 0 1
R:R:L154 R:R:W155 2.28 0 No Yes 8 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single4U14Tiotropium4U14-M3-Tiotropium
100.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
100.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
91.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
91.67Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
91.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
90.91Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
90.91Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
90.91Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
84.62Single4U15Tiotropium4U15-M3-Tiotropium
84.62Single6OL9Tiotropium6OL9-M5-Tiotropium
84.62Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
84.62Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
84.62Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
83.33Single4DAJTiotropium4DAJ-M3-Tiotropium
83.33Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
83.33Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
83.33Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
83.33Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
83.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
83.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
83.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
78.57Single5CXVTiotropium5CXV-M1-Tiotropium
78.57Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
78.57Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
76.92Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
76.92Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
76.92Single8EA0Iperoxo8EA0-M3-Iperoxo
76.92Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
75.00Single3RZECidoxepin3RZE-H1-Cidoxepin
75.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
75.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
75.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
73.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
73.33Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
73.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
71.43Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
71.43Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
71.43Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
71.43Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
71.43Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
69.23Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
69.23Single5DSGTiotropium5DSG-M4-Tiotropium
69.23Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
69.23Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
69.23Single8X63Mepyramine8X63-H1-Mepyramine
69.23Consensushistamine_onOrthosteric Ligandh1_on h4_on
69.23Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
66.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
66.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
64.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
64.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
64.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
61.54Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
61.54Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
61.54Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
61.54Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
60.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
60.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
60.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
60.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
60.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
60.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
60.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
60.00Consensushistamine_offOrthosteric Ligandh1_off
58.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Single7SRQLSD7SRQ-5-HT2B-LSD
58.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
58.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
57.14Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
57.14Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
57.14Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
57.14Single7WC7Lisuride7WC7-5-HT2A-Lisuride
57.14Single8JJOAlprenolol8JJO-β2-Alprenolol
57.14Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
57.14Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
57.14Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
57.14Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
57.14Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
57.14Consensustar_onOrthosteric Ligandta1_on
56.25Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
56.25Single6ZG4HTL00099366ZG4-M1-HTL0009936
56.25Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
56.25Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
53.85Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
53.85Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
53.85Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
53.85Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
53.85Consensusalpha1_onOrthosteric Ligandalpha1a_on
53.85Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
53.85Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
53.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
53.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
53.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
53.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
53.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
53.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
53.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single2YDVNECA2YDV-A2A-NECA
50.00Single4UHRCGS216804UHR-A2A-CGS21680
50.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
50.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
50.00Single5G53NECA5G53-A2A-NECA-Gs
50.00Single6A94Zotepine6A94-5-HT2A-Zotepine
50.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
50.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
50.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
50.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
50.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
50.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7SK9CCX6627SK9-ACKR3-CCX662
50.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGIEpinephrine8GGI-β2-Epinephrine
50.00Single8GGKEpinephrine8GGK-β2-Epinephrine
50.00Single8GGMEpinephrine8GGM-β2-Epinephrine
50.00Single8GGPEpinephrine8GGP-β2-Epinephrine
50.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
50.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
50.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
50.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
50.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
50.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
50.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
50.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single4AMIBucindolol4AMI-β1-Bucindolol
47.06Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
47.06Single6CM4Risperidone6CM4-D2-Risperidone
47.06Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
47.06Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
47.06Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
47.06Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
47.06Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
46.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
46.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
46.67Single6DRXLisuride6DRX-5-HT2B-Lisuride
46.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.67Single6H7MSalbutamol6H7M-β1-Salbutamol
46.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
46.67Single6PS1Timolol6PS1-β2-Timolol
46.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
46.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
46.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
46.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
46.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
46.67Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GGJEpinephrine8GGJ-β2-Epinephrine
46.67Single8GGNEpinephrine8GGN-β2-Epinephrine
46.67Single8GGOEpinephrine8GGO-β2-Epinephrine
46.67Single8GGUEpinephrine8GGU-β2-Epinephrine
46.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
46.67Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8X64Desloratadine8X64-H1-Desloratadine
46.67Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
46.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
46.67Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
46.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
46.67Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
46.67Consensustachykinin_offOrthosteric Ligandnk1_off
46.15Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
46.15Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
46.15Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
46.15Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
46.15Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
46.15Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8GGSEpinephrine8GGS-β2-Epinephrine
46.15Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
46.15Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
44.44Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
44.44Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
44.44Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
44.44Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
44.44Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
44.44Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
44.44Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
44.44Single7UM4AS26747237UM4-5-HT5A-AS2674723
44.44Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
44.44Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
44.44Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
44.44Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
43.75Single2Y03Isoprenaline2Y03-β1-Isoprenaline
43.75Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
43.75Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
43.75Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
43.75Single6E67BI1671076E67-β2-BI167107-Gs (fused)
43.75Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
43.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
43.75Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
43.75Single6PS6Timolol6PS6-β2-Timolol
43.75Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
43.75Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
43.75Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
43.75Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
43.75Single7WC6LSD7WC6-5-HT2A-LSD
43.75Single7XKAEpinephrine7XKA-β2-Epinephrine
43.75Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
43.75Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
43.75Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
43.75Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
43.75Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
43.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
43.75Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
43.75Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
43.75Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
43.75Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
43.75Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
42.86Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
42.86Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
42.86Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
42.86Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
42.86Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
42.86Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
42.86Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
42.86Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
42.86Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGVEpinephrine8GGV-β2-Epinephrine
42.86Single8GGWEpinephrine8GGW-β2-Epinephrine
42.86Single8GGXEpinephrine8GGX-β2-Epinephrine
42.86Single8GH0Epinephrine8GH0-β2-Epinephrine
42.86Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8IWESpermidine8IWE-TAAR9-Spermidine
42.86Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
42.86Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
42.86Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
42.86Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
42.86Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
42.11Single3NY9PubChem 9131033NY9-β2-PubChem 913103
42.11Single4UG2CGS216804UG2-A2A-CGS21680
42.11Single8X5YAstemizole8X5Y-H1-Astemizole
41.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single3P0GBI1671073P0G-β2-BI167107
41.18Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
41.18Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
41.18Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
41.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
41.18Single6E59L-7607356E59-NK1-L-760735
41.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
41.18Single6J20Aprepitant6J20-NK1-Aprepitant
41.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
41.18Single6WGTLSD6WGT-5-HT2A-LSD
41.18Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
41.18Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
41.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
41.18Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
41.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
41.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
41.18Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
41.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
41.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
41.18Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Consensus5ht5_offOrthosteric Ligand5ht5a_off
41.18Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
41.18Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
41.18Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
41.18Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
41.18Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
40.00Single2YDOAdenosine2YDO-A2A-Adenosine
40.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
40.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
40.00Single6TPNHTL66416TPN-OX2-HTL6641
40.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
40.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
40.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
40.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
40.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
40.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
40.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
40.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGLEpinephrine8GGL-β2-Epinephrine
40.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
40.00Single8GGTEpinephrine8GGT-β2-Epinephrine
40.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
40.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
40.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
40.00Consensussensory_offOrthosteric Ligandopsin_off
38.89Single4LDEBI1671074LDE-β2-BI167107
38.89Single6A93Risperidone6A93-5-HT2A-Risperidone
38.89Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.89Single6MXTSalmeterol6MXT-β2-Salmeterol
38.89Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
38.89Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
38.89Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.89Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.89Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single7YITNalfurafine7YIT-κ-Nalfurafine
38.89Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.89Single8JJ8Formoterol8JJ8-β2-Formoterol
38.89Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.89Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
38.89Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
38.89Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
38.89Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.89Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
38.46Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single8GGREpinephrine8GGR-β2-Epinephrine
38.46Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
38.46Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single3QAKUK-4320973QAK-A2A-UK-432097
38.10Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
37.50Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
37.50Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
37.50Single2Y02Carmoterol2Y02-β1-Carmoterol
37.50Single2Y04Salbutamol2Y04-β1-Salbutamol
37.50Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
37.50Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
37.50Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
37.50Single4EJ4Naltrindole4EJ4-δ-Naltrindole
37.50Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
37.50Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
37.50Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
37.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
37.50Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
37.50Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
37.50Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
37.50Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
37.50Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
37.50Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
37.50Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
37.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
37.50Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
37.50Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
37.50Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
37.50Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
37.50Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
36.84Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.84Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.84Single6H7LDobutamine6H7L-β1-Dobutamine
36.84Single6IBLArformoterol6IBL-β1-Arformoterol
36.84Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
36.84Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
36.84Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
36.84Consensusendothelin_offOrthosteric Ligandetb_off
36.84Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
36.84Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.71Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
35.71Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
35.71Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.71Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
35.71Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
35.71Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GGYEpinephrine8GGY-β2-Epinephrine
35.71Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
35.71Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Single5C1MBU725C1M-μ-BU72
35.29Single5TVNLSD5TVN-5-HT2B-LSD
35.29Single5WIUNemonapride5WIU-D4-Nemonapride
35.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
35.29Single5XPRBosentan5XPR-ETB-Bosentan
35.29Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
35.29Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
35.29Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
35.29Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
35.29Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
35.29Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
35.29Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
35.29Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
35.29Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
35.00Single5ZTYAM102575ZTY-CB2-AM10257
35.00Single6PT3DPI-2876PT3-δ-DPI-287
35.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
34.78Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
33.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
33.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
33.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single5X93K-87945X93-ETB-K-8794
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6KUXRS-799486KUX-α2a-RS-79948
33.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
33.33Single7EPENAM5637EPE-mGlu-NAM563
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
33.33Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
33.33Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
33.33Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
33.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
33.33Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
33.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
33.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
33.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
33.33Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.82Single6HLOAprepitant6HLO-NK1-Aprepitant
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.58Single6HLPNetupitant6HLP-NK1-Netupitant
31.58Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.58Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.58Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Single8JJLOlodaterol8JJL-β2-Olodaterol
31.58Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
31.58Single8JWZAB9288JWZ-A2A-AB928-Na
31.58Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.58Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.58Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
31.25Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
31.25Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
31.25Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
31.25Single4MBSMaraviroc4MBS-CCR5-Maraviroc
31.25Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
31.25Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.25Single6TPGEMPA6TPG-OX2-EMPA
31.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.25Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.25Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.25Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single7T32ZM2413857T32-A2A-ZM241385
31.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
31.25Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.25Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
31.25Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
31.25Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
31.25Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
31.25Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
31.25Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
30.77Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
30.43Single6PT2KGCHM076PT2-δ-KGCHM07
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
30.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single7EZCUKA7EZC-A2A-UKA
30.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
30.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single2Y01Dobutamine2Y01-β1-Dobutamine
29.41Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
29.41Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
29.41Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
29.41Single5TGZAM65385TGZ-CB1-AM6538
29.41Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
29.41Single6TOTLemborexant6TOT-OX1-Lemborexant
29.41Single7BU7BI1671077BU7-β1-BI167107
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
29.41Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Single8CU6LJ-45178CU6-A2A-LJ-4517
29.41Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
29.41Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
29.41Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
29.41Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Consensusadenosine_onOrthosteric Liganda1_on a2_on
29.41Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusleuko_onOrthosteric Ligandblt_on
29.41Consensusnucleotide_onOrthosteric Ligandadenosine_on
29.17Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
28.57Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
28.57Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single5WF6UK-4320975WF6-A2A-UK-432097
28.57Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
28.57Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8GGZEpinephrine8GGZ-β2-Epinephrine
28.57Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
28.57Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
28.57Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single2Y00Dobutamine2Y00-β1-Dobutamine
27.78Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
27.78Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
27.78Single5CGCHTL142425CGC-mGlu5-HTL14242
27.78Single5NM2ZM2413855NM2-A2A-ZM241385-Na
27.78Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
27.78Single5WQCEMPA5WQC-OX2-EMPA
27.78Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
27.78Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.78Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
27.78Single6TP6Filorexant6TP6-OX1-Filorexant
27.78Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.78Single7C4SS1P7C4S-S1P3-S1P
27.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
27.78Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
27.78Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
27.78Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
27.78Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
27.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
27.27Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
27.27Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
26.67Single3PBLEticlopride3PBL-D3-Eticlopride
26.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
26.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
26.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GH1Epinephrine8GH1-β2-Epinephrine
26.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
26.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
26.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
26.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single4DJHJDTic4DJH-κ-JDTic
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.32Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
26.32Single7W41PD1762527W41-BB2-PD176252
26.32Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.32Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
26.32Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
26.32Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
26.32Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusadenosine_offOrthosteric Liganda1_off a2_off
26.32Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.32Consensusbombesin_offOrthosteric Ligandbb2_off
26.32Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
26.32Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
26.32Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.32Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
26.32Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.09Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.09Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.09Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
26.09Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.93Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
25.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
25.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
25.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
25.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6TODEMPA6TOD-OX1-EMPA-Na
25.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
25.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
25.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
25.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
25.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusgt_class-aOrthosteric Ligandgt_opsin
25.00Consensusgt_opsinOrthosteric Ligandgt_sensory
25.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
25.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
25.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
24.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
24.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
23.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.81Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
23.81Single5CGDHTL142425CGD-mGlu5-HTL14242
23.81Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
23.81Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
23.81Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
23.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
23.81Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
23.81Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
23.81Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusorexin_onOrthosteric Ligandox2_on
23.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
23.53Single4ZJCSB-6740424ZJC-OX1-SB-674042
23.53Single5IU7Q274563465IU7-A2A-Q27456346-Na
23.53Single5JTBZM2413855JTB-A2A-ZM241385
23.53Single5K2BZM2413855K2B-A2A-ZM241385-Na
23.53Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
23.53Single6AQFZM2413856AQF-A2A-ZM241385
23.53Single6DS0Ly2660976DS0-5-HT2B-Ly266097
23.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
23.53Single6IQLL7458706IQL-D4-L745870
23.53Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
23.53Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
23.53Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
23.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
23.53Single6TPKRetosiban6TPK-OT-Retosiban
23.53Single6VI4JDTic6VI4-κ-JDTic
23.53Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
23.53Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
23.53Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
23.53Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
23.53Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
23.53Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
23.53Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
23.53Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
23.53Consensuss1p_offOrthosteric Ligands1p1_off
23.53Consensusvasopressin-ot_offOrthosteric Ligandot_off
23.08Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
23.08Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
23.08Single7WC4Serotonin7WC4-5-HT2A-Serotonin
23.08Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.73Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
22.73Consensuslpl_offOrthosteric Ligands1p_off lpa_off
22.73Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.73Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single3EMLZM2413853EML-A2A-ZM241385
22.22Single4EIYZM2413854EIY-A2A-ZM241385-Na
22.22Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single5IU8Q274563475IU8-A2A-Q27456347-Na
22.22Single5K2AZM2413855K2A-A2A-ZM241385-Na
22.22Single5OLGZM2413855OLG-A2A-ZM241385-Na
22.22Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
22.22Single5VRAZM2413855VRA-A2A-ZM241385-Na
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6FFHFenobam6FFH-mGlu5-Fenobam
22.22Single6S0LZM2413856S0L-A2A-ZM241385
22.22Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
22.22Single7F83PF-051904577F83-Ghrelin-PF-05190457
22.22Single7PYRPSB-21157PYR-A2A-PSB-2115
22.22Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
22.22Single7UL4Alvimopan7UL4-μ-Alvimopan
22.22Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
22.22Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
22.22Consensusa2_offOrthosteric Liganda2a_off
22.22Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
22.22Consensusclass-d_onOrthosteric Ligandste2_on
22.22Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Consensusgi_hcarOrthosteric Ligandgi_hca
22.22Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.74Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.74Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
21.74Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.74Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.74Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.74Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
21.43Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusendothelin_onOrthosteric Ligandetb_on eta_on
21.43Consensusgi_class-dOrthosteric Ligandgi_ste
21.43Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43Consensusgo_class-b1Orthosteric Ligandgo_crf
21.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.43Consensussensory_onOrthosteric Ligandopsin_on
21.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
21.05Single5IUAQ274563485IUA-A2A-Q27456348-Na
21.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
21.05Single5N2SPSB365N2S-A1-PSB36
21.05Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
21.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
21.05Single6LPLZM2413856LPL-A2A-ZM241385-Na
21.05Single6S0QZM2413856S0Q-A2A-ZM241385
21.05Single6WQAZM2413856WQA-A2A-ZM241385-Na
21.05Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.05Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
21.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.05Single7RM5ZM2413857RM5-A2A-ZM241385-Na
21.05Single7SINNPS-21437SIN-CaS-NPS-2143
21.05Single7SINNPS-21437SIN-CaS-NPS-2143
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
21.05Single8FYNZM2413858FYN-A2A-ZM241385-Na
21.05Single8GNEKW-63568GNE-A2A-KW-6356-Na
21.05Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
21.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
21.05Single8QOTNanobody E8QOT-μ-Nanobody E
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.05Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
20.69Single6IGLIRL16206IGL-ETB-IRL1620
20.69Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.69Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
20.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
20.00Single7P2L4YI7P2L-mGlu5-4YI
20.00Single7PX4PSB-21137PX4-A2A-PSB-2113
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
20.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
20.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
19.35Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.23Single6JODAngiotensin II6JOD-AT2-Angiotensin II
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.23Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusclass-d_onOrthosteric Ligandste2_on
19.23Consensusgi_class-dOrthosteric Ligandgi_ste
19.23Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.23Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
19.23Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
19.05Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
19.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
19.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
19.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
19.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
19.05Consensusdp_offOrthosteric Liganddp2_off
19.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
19.05Consensusgi_class-fOther Ligandgi_frizzled
19.05Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
19.05Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.05Consensusgs_steroidOrthosteric Ligandgs_bileacid
19.05Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
18.75Single6HLLCP999946HLL-NK1-CP99994
18.75Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.75Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
18.75Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
18.52Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
18.52Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
18.52Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
18.52Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
18.18Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.18Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
18.18Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
18.18Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
18.18Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensussteroid_onOrthosteric Ligandbileacid_on
17.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
17.65Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
17.65Single5K2DZM2413855K2D-A2A-ZM241385
17.65Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.65Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single5WS3EMPA5WS3-OX2-EMPA
17.65Single6JZHZM2413856JZH-A2A-ZM241385-Na
17.65Single6PS7ZM2413856PS7-A2A-ZM241385-Na
17.65Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single7XRRLemborexant7XRR-OX2-Lemborexant
17.65Single8GNGIstradefylline8GNG-A2A-Istradefylline
17.65Single8IHKAcifran8IHK-HCA3-Acifran
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.39Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
17.39Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XN9L-054,5227XN9-SST2-L-054,522
17.39Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
17.39Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
17.39Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
17.39Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
17.39Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.39Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusgs_class-b2Orthosteric Ligandgs_adgr
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.24Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.24Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single3REYPubChem 56973REY-A2A-PubChem 5697
16.67Single5IU4ZM2413855IU4-A2A-ZM241385-Na
16.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.67Single5K2CZM2413855K2C-A2A-ZM241385-Na
16.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
16.67Single5NM4ZM2413855NM4-A2A-ZM241385-Na
16.67Single5UVIZM2413855UVI-A2A-ZM241385
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6MH8ZM2413856MH8-A2A-ZM241385
16.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
16.67Single6V9SGTPL114036V9S-OX1-GTPL11403
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
16.67Single7AROLUF58337ARO-A2A-LUF5833-Na
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7F8XNN90567F8X-CCKA-NN9056
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
16.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
16.67Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
16.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
16.67Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensusclass-d_offOrthosteric Ligandste2_off
16.67Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
16.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
16.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
16.67Consensushcar_onOrthosteric Ligandhca_on
16.67Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
16.67Consensussst_onOrthosteric Ligandsst2_on sst4_on
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.13Single5GLHEndothelin-15GLH-ETB-Endothelin-1
16.13Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.13Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
16.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
16.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
16.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
16.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
16.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
15.79Single4YAYZD-71554YAY-AT1-ZD-7155
15.79Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.79Single5UENDU1725UEN-A1-DU172
15.79Single6D27CAY104716D27-DP2-CAY10471
15.79Single6GPSMK08126GPS-CCR2-MK0812
15.79Single6IIVDaltroban6IIV-TP-Daltroban
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
15.79Single6LPJZM2413856LPJ-A2A-ZM241385-Na
15.79Single6LPKZM2413856LPK-A2A-ZM241385-Na
15.79Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.79Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
15.79Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
15.79Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.79Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
15.79Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.79Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
15.79Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
15.79Single8K5DGSK2560738K5D-HCA2-GSK256073
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
15.79Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.79Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
15.79Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.79Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
15.79Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
15.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.38Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.38Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Single6W25SHU91196W25-MC4-SHU9119-Ca
15.38Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
15.38Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
15.38Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.38Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.15Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
15.15Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.00Single6GPXMK08126GPX-CCR2-MK0812
15.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
15.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.71Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.71Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
14.29Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.29Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
14.29Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.29Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
14.29Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
14.29Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
14.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
14.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8PWNTheophylline8PWN-A2A-Theophylline
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Consensuscck_onOrthosteric Ligandccka_on cckb_on
14.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.29Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.29Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Consensuslpa_onOrthosteric Ligandlpa1_on
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Single6FJ3PTH6FJ3-PTH1-PTH
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
13.79Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
13.79Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
13.79Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.79Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
13.64Single4N4WSANT-14N4W-SMO-SANT-1
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6IIURamatroban6IIU-TP-Ramatroban
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
13.64Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
13.64Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
13.64Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
13.64Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
13.64Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
13.64Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
13.64Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.51Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single3RFMCaffeine3RFM-A2A-Caffeine
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.33Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
13.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.33Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
13.33Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
13.04Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.04Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
13.04Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
13.04Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.04Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.04Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.04Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.90Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.90Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
12.90Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
12.50Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
12.50Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
12.50Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
12.50Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
12.50Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.50Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
12.50Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.12Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.12Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.12Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.12Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.12Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
12.00Single4XT1Fractalkine4XT1-US28-Fractalkine
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
11.76Single3OE9IT1t3OE9-CXCR4-IT1t
11.76Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.76Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
11.76Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
11.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
11.76Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.54Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
11.54Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.54Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
11.54Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
11.54Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
11.54Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
11.54Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
11.43Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
11.43Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single3OE0CVX153OE0-CXCR4-CVX15
11.11Single3PWHZM2413853PWH-A2A-ZM241385
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
11.11Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
11.11Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
11.11Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.71Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
10.71Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.71Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
10.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
10.71Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
10.71Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
10.53Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.53Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.53Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.53Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.53Single8IYXYL-3658IYX-GPR34-YL-365
10.53Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.53Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.53Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.34Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.34Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
10.34Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
10.34Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.34Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
10.34Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.34Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
10.34Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.34Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.00Single4XT3Fractalkine4XT3-US28-Fractalkine
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Consensushcar_offOrthosteric Ligandsuccinate_off
10.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.76Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
9.68Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.68Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.68Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.68Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.52Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.52Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.52Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.52Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.52Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
9.52Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
9.52Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
9.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.52Consensusep_offOrthosteric Ligandep4_off
9.52Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.38Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.38Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
9.09Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.09Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09Consensuschemerin_onOrthosteric Ligandcml1_on
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
9.09Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.09Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.70Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.70Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
8.70Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.70Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
8.70Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.70Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
8.70Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
8.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
8.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
8.33Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
7.69Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
7.69Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
7.69Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
7.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.69Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.69Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
7.69Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
7.69Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
7.69Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
7.41Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
7.41Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.41Single7SHEPI; PE7SHE-GPR158-PI; PE
7.41Single7SK5CXCL127SK5-ACKR3-CXCL12
7.41Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensussst_offOrthosteric Ligandsst2_off
7.32Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.14Single7XNACYN1548067XNA-SST2-CYN154806
7.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.14Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.14Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
6.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.90Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
6.90Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.90Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.67Consensusclass-c_onOther Ligandgabab_on mglu_on
6.67Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.45Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.45Single7SK3CXCL127SK3-ACKR3-CXCL12
6.45Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.45Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.45Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.06Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.88Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.88Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.88Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.56Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.56Single5L7IVismodegib5L7I-SMO-Vismodegib
5.56Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.56Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.56Consensusclass-t_onOrthosteric Ligandtaste2_on
5.56Consensusgs_class-tOrthosteric Ligandgs_taste
5.56Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.41Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.26Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.26Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.26Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.26Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.26Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.26Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.26Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.00Single8K2WAMG4878K2W-CXCR3-AMG487
5.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.76Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.55Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.55Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.55Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.55Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
4.35Single5V56TC1145V56-SMO-TC114
4.35Single5V57TC1145V57-SMO-TC114
4.35Single6OS1TRV0266OS1-AT1-TRV026
4.35Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.35Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.35Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.35Consensusrelaxin_onOrthosteric Ligandrxfp4_on
4.17Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.17Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.17Single6OS2TRV0266OS2-AT1-TRV026
4.17Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.17Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.17Consensuschemokine_offOrthosteric Ligandcxcr_off
4.17Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.17Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.17Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
3.85Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
3.85Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.57Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.12Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.03Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.94Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

PDB Summary
PDB 4MQS
Class A
SubFamily Amine
Type Acetylcholine (muscarinic)
SubType M2
Species Homo sapiens
Ligand Iperoxo
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.5
Date 2013-11-27
D.O.I. 10.1038/nature12735
Net Summary
Imin 3.65
Number of Linked Nodes 263
Number of Links 304
Number of Hubs 43
Number of Links mediated by Hubs 166
Number of Communities 7
Number of Nodes involved in Communities 66
Number of Links involved in Communities 100
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 63620
Length Of Smallest Path 3
Average Path Length 13.2311
Length of Longest Path 26
Minimum Path Strength 1.38
Average Path Strength 7.58868
Maximum Path Strength 24.36
Minimum Path Correlation 0.7
Average Path Correlation 0.927716
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 51.3367
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.9846
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeIXO
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeIXO
Name4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
SynonymsIperoxo
Identifier4-(4,5-dihydro-1,2-oxazol-3-yloxy)but-2-ynyl-trimethyl-azanium
FormulaC10 H17 N2 O2
Molecular Weight197.254
SMILESC[N+](C)(C)CC#CCOC1=NOCC1
PubChem10104167
Formal Charge1
Total Atoms31
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP08172
Sequence
>4MQS_Chain_R
KTFEVVFIV LVAGSLSLV TIIGNILVM VSIKVNRHL QTVNNYFLF 
SLACADLII GVFSMNLYT LYTVIGYWP LGPVVCDLW LALDYVVSN 
ASVMNLLII SFDRYFCVT KPLTYPVKR TTKMAGMMI AAAWVLSFI 
LWAPAILFW QFIVGVRTV EDGECYIQF FSNAAVTFG TAIAAFYLP 
VIIMTVLYW HISRASKSP PPSREKKVT RTILAILLA FIITWAPYN 
VMVLINTFC APCIPNTVW TIGYWLCYI NSTINPACY ALCNATFKK 
TFKHLLM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3EMLANucleotideAdenosineA2AHomo sapiensZM241385--2.62008-10-1410.1126/science.1164772
3PWHANucleotideAdenosineA2AHomo sapiensZM241385--3.32011-09-0710.1016/j.str.2011.06.014
3VG9ANucleotideAdenosineA2AHomo sapiensZM241385Antibody-2.72012-02-0110.1038/nature10750
3VGAANucleotideAdenosineA2AHomo sapiensZM241385Antibody-3.12012-02-0110.1038/nature10750
4EIYANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82012-07-2510.1126/science.1219218
5IU4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.722016-06-2910.1021/acs.jmedchem.6b00653
5JTBANucleotideAdenosineA2AHomo sapiensZM241385--2.82017-05-3110.1126/sciadv.1602952
5K2AANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2BANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2CANucleotideAdenosineA2AHomo sapiensZM241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2DANucleotideAdenosineA2AHomo sapiensZM241385--1.92016-09-2110.1126/sciadv.1600292
5NLXANucleotideAdenosineA2AHomo sapiensZM241385Na-2.142017-09-2710.1038/s41467-017-00630-4
5NM2ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.952017-09-2710.1038/s41467-017-00630-4
5NM4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5OLGANucleotideAdenosineA2AHomo sapiensZM241385Na-1.872018-01-1710.1038/s41598-017-18570-w
5UVIANucleotideAdenosineA2AHomo sapiensZM241385--3.22017-05-2410.1107/S205225251700570X
5VRAANucleotideAdenosineA2AHomo sapiensZM241385Na-2.352017-12-1310.1038/nprot.2017.135
6AQFANucleotideAdenosineA2AHomo sapiensZM241385--2.512018-01-1010.1016/j.cell.2017.12.004
6JZHANucleotideAdenosineA2AHomo sapiensZM241385Na-2.252019-10-3010.1107/S1600576719012846
6LPJANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPKANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPLANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-2510.1038/s41598-020-76277-x
6MH8ANucleotideAdenosineA2AHomo sapiensZM241385--4.22019-04-2410.1107/S205225251900263X
6PS7ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.852019-11-1310.1107/S2052252519013137
6S0LANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6S0QANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6WQAANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-1810.1107/S2052252520012701
7RM5ANucleotideAdenosineA2AHomo sapiensZM241385Na-2.792021-09-0810.1073/pnas.2106041118
7T32ANucleotideAdenosineA2AHomo sapiensZM241385--3.42022-08-1010.1038/s41467-022-32125-2
8FYNANucleotideAdenosineA2AHomo sapiensZM241385Na-22023-03-0810.1038/s41467-023-36733-4
7Y66APeptideComplement peptideC5a1Homo sapiensBM213-Gi1/&β;1/&γ;22.92023-03-0110.1038/s41422-023-00779-2
6UUSB1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-Gs/&β;1/&γ;2; RAMP32.42020-04-0110.1021/acsptsci.9b00080
6UVAB1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-2-Gs/&β;1/&γ;2; RAMP32.32020-04-0110.1021/acsptsci.9b00080
3UONAAmineAcetylcholine (muscarinic)M2Homo sapiensQuinuclidinyl benzilate hydrobromide--32012-02-0110.1038/nature10753
4MQTAAmineAcetylcholine (muscarinic)M2Homo sapiensIperoxoLY2119620-3.72013-11-2710.1038/nature12735
5YC8AAmineAcetylcholine (muscarinic)M2Homo sapiensN-Methyl Scopolamine--2.52018-11-2110.1038/s41589-018-0152-y
5ZK3AAmineAcetylcholine (muscarinic)M2Homo sapiensQuinuclidinyl benzilate hydrobromide--2.62018-11-2110.1038/s41589-018-0152-y
5ZK8AAmineAcetylcholine (muscarinic)M2Homo sapiensN-Methyl Scopolamine--32018-11-2110.1038/s41589-018-0152-y
5ZKBAAmineAcetylcholine (muscarinic)M2Homo sapiensAF-DX 384--2.952018-11-2110.1038/s41589-018-0152-y
5ZKCAAmineAcetylcholine (muscarinic)M2Homo sapiensN-Methyl Scopolamine--2.32018-11-2110.1038/s41589-018-0152-y
6OIKAAmineAcetylcholine (muscarinic)M2Homo sapiensIperoxoLY2119620chim(NtGi1-Go)/&β;1/&γ;23.62019-05-0810.1126/science.aaw5188
6U1NAAmineAcetylcholine (muscarinic)M2Homo sapiens-LY2119620Arrestin242020-02-2610.1038/s41586-020-1954-0
7T8XAAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholine-chim(NtGi1-Go)/&β;1/&γ;23.212023-01-2510.1038/s41467-022-35726-z
7T90AAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholine-chim(NtGi1-Go)/&β;1/&γ;23.322023-01-2510.1038/s41467-022-35726-z
7T94AAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholinePubChem 57664406chim(NtGi1-Go)/&β;1/&γ;23.162023-01-2510.1038/s41467-022-35726-z
7SBFAPeptideOpioidμMus musculusPZM21-Gi1/&β;1/&γ;22.92022-04-2010.1002/anie.202200269
8EFOAPeptideOpioidμHomo sapiensPZM21-Gi1/&β;1/&γ;22.82022-11-0910.1016/j.cell.2022.09.041
7T9NAProteinGlycoprotein hormoneTSHHomo sapiensM22 FabPubChem 644078Gs/&β;1/&γ;22.92022-08-0310.1038/s41586-022-05159-1
7XW6AProteinGlycoprotein hormoneTSHHomo sapiensM22 FabML109Gs/&β;1/&γ;22.782022-08-1710.1038/s41586-022-05173-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4MQS.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.