Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:H8 7.585416
2R:R:F13 6.545406
3R:R:R14 11.5967614
4R:R:Y15 9.945405
5R:R:F18 11.406505
6R:R:Y22 7.506508
7R:R:F26 5.68407
8R:R:E51 8.23406
9R:R:I52 7.2225427
10R:R:F55 6.858507
11R:R:M56 6.445408
12R:R:N58 8.7375439
13R:R:T60 5.0025459
14R:R:F66 7.552567
15R:R:W73 10.1517
16R:R:Y76 8.45616
17R:R:Y77 11.27506
18R:R:W83 7.934518
19R:R:F98 7.0725405
20R:R:Y102 8.815408
21R:R:F107 8.27538
22R:R:T112 6.91409
23R:R:R115 7.65629
24R:R:Y116 8.40333648
25R:R:S157 7.5125405
26R:R:V170 6.04403
27R:R:R172 8.4775404
28R:R:C173 7.41419
29R:R:F174 5.68514
30R:R:E175 9.9525414
31R:R:Y177 7.2075416
32R:R:H188 10.9425414
33R:R:F195 14.0375479
34R:R:I210 3.0575405
35R:R:L238 4.1575488
36R:R:F241 6.138579
37R:R:H248 9.8525407
38R:R:Q252 6.6875407
39R:R:W255 15.156515
40R:R:E259 7.6975412
41R:R:N272 8.835414
42R:R:Q276 12.755414
43R:R:C286 5.3225468
44R:R:N289 10.4775409
45R:R:Y293 9.335459
46R:R:F295 8.8125427
47L:L:?1 12.9211910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:R14 R:R:Y15 15.41417.49YesYes045
2R:R:E175 R:R:R172 29.567411.63YesYes044
3R:R:F18 R:R:Q276 10.213512.88YesYes054
4R:R:R14 R:R:Y77 22.55511.32YesYes046
5R:R:F18 R:R:Y22 16.82169.28YesYes058
6L:L:?1 R:R:Y77 40.86158.64YesYes006
7L:L:?1 R:R:Y22 11.30145.98YesYes008
8R:R:L70 R:R:Y22 13.91087.03NoYes088
9R:R:C286 R:R:L67 12.2684.76YesNo086
10R:R:C286 R:R:F66 1005.59YesYes687
11R:R:F66 R:R:F97 86.97867.5YesNo077
12L:L:?1 R:R:F97 87.640119.32YesNo007
13R:R:D63 R:R:N33 82.237512.12NoNo099
14R:R:C286 R:R:D63 93.23026.22YesNo089
15R:R:N33 R:R:T60 82.41027.31NoYes099
16R:R:D63 R:R:N289 15.601512.12NoYes099
17R:R:T60 R:R:Y293 78.51454.99YesYes599
18R:R:M56 R:R:Y293 76.02638.38YesYes089
19R:R:I52 R:R:R115 32.85318.77YesYes279
20R:R:I52 R:R:M56 66.14364.37YesYes078
21R:R:F107 R:R:N58 10.621510.87YesYes389
22R:R:F107 R:R:F55 28.62664.29YesYes087
23R:R:F55 R:R:I111 30.90155.02YesNo078
24R:R:I111 R:R:I52 31.12214.42NoYes087
25R:R:F107 R:R:W142 12.16887.02YesNo389
26R:R:W73 R:R:Y76 15.07966.75YesYes176
27R:R:Y76 R:R:Y77 16.086610.92YesYes066
28L:L:?1 R:R:W73 27.630629.69YesYes107
29R:R:E175 R:R:Y76 17.49797.86YesYes146
30R:R:W83 R:R:Y76 11.01479.65YesYes186
31R:R:R172 R:R:V170 24.85577.85YesYes043
32R:R:F174 R:R:S157 11.45587.93YesYes045
33L:L:?1 R:R:F174 11.31989.66YesYes104
34R:R:F152 R:R:F98 33.70949.65NoYes055
35L:L:?1 R:R:F152 31.113.11YesNo105
36R:R:F98 R:R:Y102 31.074310.32YesYes058
37R:R:C103 R:R:W142 10.87887.84NoNo079
38R:R:H248 R:R:Q252 48.10919.89YesYes077
39R:R:H188 R:R:Q252 36.40717.42YesYes047
40L:L:?1 R:R:H188 34.7913.11YesYes104
41R:R:Q252 R:R:W255 15.78896.57YesYes075
42R:R:H249 R:R:Y102 27.23367.62NoYes088
43R:R:H248 R:R:H249 38.65637.17YesNo078
44R:R:N285 R:R:N289 13.02149.54NoYes099
45R:R:F195 R:R:H249 63.115130.55YesNo098
46R:R:F195 R:R:F241 48.32596.43YesYes799
47R:R:F241 R:R:I202 33.9638.79YesNo097
48R:R:I202 R:R:T112 32.32396.08NoYes079
49R:R:N206 R:R:T112 29.214613.16NoYes099
50R:R:I209 R:R:Y116 18.51963.63NoYes088
51R:R:I209 R:R:V119 19.86844.61NoNo088
52R:R:D230 R:R:V119 22.6915.84NoNo078
53R:R:D230 R:R:R115 28.40610.72NoYes079
54L:L:?1 R:R:Y177 16.931911.29YesYes106
55R:R:V184 R:R:Y177 20.01546.31NoYes036
56R:R:L260 R:R:V184 10.93025.96NoNo013
57R:R:F195 R:R:F196 10.103313.93YesNo095
58R:R:F199 R:R:V246 13.75656.55NoNo066
59R:R:A234 R:R:N206 20.79834.69NoNo089
60R:R:L231 R:R:R228 10.45616.07NoNo055
61R:R:I210 R:R:L231 12.19824.28YesNo055
62R:R:A234 R:R:I210 19.09293.25NoYes085
63R:R:H248 R:R:T278 10.68038.21YesNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R14 R:R:Y77 11.32 1 Yes Yes 4 6 2 1
R:R:F18 R:R:Y22 9.28 0 Yes Yes 5 8 2 1
R:R:F18 R:R:Y77 22.69 0 Yes Yes 5 6 2 1
R:R:F18 R:R:L279 7.31 0 Yes No 5 6 2 1
R:R:L70 R:R:Y22 7.03 0 No Yes 8 8 2 1
R:R:S283 R:R:Y22 11.45 0 No Yes 7 8 2 1
L:L:?1 R:R:Y22 5.98 1 Yes Yes 0 8 0 1
R:R:F66 R:R:L70 7.31 6 Yes No 7 8 2 2
R:R:F66 R:R:F97 7.5 6 Yes No 7 7 2 1
R:R:F66 R:R:S283 5.28 6 Yes No 7 7 2 2
R:R:W73 R:R:Y76 6.75 1 Yes Yes 7 6 1 2
R:R:C173 R:R:W73 6.53 1 Yes Yes 9 7 2 1
L:L:?1 R:R:W73 29.69 1 Yes Yes 0 7 0 1
R:R:Y76 R:R:Y77 10.92 1 Yes Yes 6 6 2 1
R:R:C173 R:R:Y76 5.38 1 Yes Yes 9 6 2 2
L:L:?1 R:R:Y77 8.64 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F97 19.32 1 Yes No 0 7 0 1
R:R:F152 R:R:F98 9.65 1 No Yes 5 5 1 2
R:R:F152 R:R:F174 5.36 1 No Yes 5 4 1 1
L:L:?1 R:R:F152 13.11 1 Yes No 0 5 0 1
R:R:F174 R:R:S157 7.93 1 Yes Yes 4 5 1 2
L:L:?1 R:R:F174 9.66 1 Yes Yes 0 4 0 1
R:R:V184 R:R:Y177 6.31 0 No Yes 3 6 2 1
R:R:H188 R:R:Y177 5.44 1 Yes Yes 4 6 1 1
R:R:W255 R:R:Y177 5.79 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y177 11.29 1 Yes Yes 0 6 0 1
R:R:H188 R:R:Q252 7.42 1 Yes Yes 4 7 1 2
R:R:H188 R:R:T256 17.8 1 Yes No 4 5 1 2
L:L:?1 R:R:H188 13.11 1 Yes Yes 0 4 0 1
R:R:Q252 R:R:W255 6.57 0 Yes Yes 7 5 2 2
R:R:H275 R:R:W255 41.26 0 No Yes 5 5 2 2
R:R:H275 R:R:L279 10.29 0 No No 5 6 2 1
L:L:?1 R:R:L279 5.49 1 Yes No 0 6 0 1
R:R:A93 R:R:W73 3.89 0 No Yes 5 7 2 1
R:R:V21 R:R:Y22 3.79 0 No Yes 6 8 2 1
R:R:T69 R:R:W73 3.64 0 No Yes 6 7 2 1
R:R:F174 R:R:G94 3.01 1 Yes No 4 5 1 2
R:R:P19 R:R:Y77 2.78 0 No Yes 5 6 2 1
R:R:F174 R:R:L155 2.44 1 Yes No 4 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
53.85Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
50.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
46.15Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
46.15Consensushca_onOrthosteric Ligandhca2_on
45.45Single3OE6IT1t3OE6-CXCR4-IT1t
43.75Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
43.75Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.86Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
42.86Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
42.86Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
42.86Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
42.86Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
42.86Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
42.86Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
42.86Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
42.86Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
42.86Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
42.86Consensushca_on_gpOrthosteric Ligandhca2_on_gp
42.86Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
42.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
41.67Single3OE9IT1t3OE9-CXCR4-IT1t
41.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
41.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
41.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
41.67Single8K5BNiacin8K5B-HCA2-Niacin
41.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
41.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
41.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
40.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
40.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
40.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
40.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
40.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
40.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
40.00Consensusep_offOrthosteric Ligandep4_off
38.89Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
38.89Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
38.89Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
38.46Single3ODUIT1t3ODU-CXCR4-IT1t
38.46Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
38.46Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
38.46Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
38.46Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
38.46Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
38.46Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
38.46Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
38.10Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
37.50Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
37.50Single7TUYGSK682753A7TUY-GPR183-GSK682753A
37.50Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
37.50Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
36.84Single4XT1Fractalkine4XT1-US28-Fractalkine
36.84Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
36.84Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.84Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
35.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.71Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
35.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
35.71Single8IHKAcifran8IHK-HCA3-Acifran
35.71Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
35.71Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
35.71Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
35.71Single8K5CAcipimox8K5C-HCA2-Acipimox
35.71Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
35.71Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
35.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
35.29Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
35.29Single8XYIVUF106618XYI-CXCR3-VUF10661
35.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
35.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
33.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
33.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7V3ZCP559407V3Z-CB1-CP55940
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
33.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
33.33Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
33.33Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
33.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
31.82Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
31.82Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
31.82Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
31.58Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
31.58Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.58Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.58Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
31.58Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
31.58Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
31.58Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
31.58Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
31.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.25Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.25Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
31.25Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
31.25Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
31.25Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
31.25Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.25Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
31.25Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.25Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.25Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
31.25Consensusdp_offOrthosteric Liganddp2_off
31.25Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
31.25Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
31.25Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.25Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.77Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
30.77Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
30.77Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
30.77Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
30.43Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
30.43Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.43Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
30.43Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
30.43Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
30.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
30.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
30.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
30.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
29.41Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
29.41Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
29.41Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
29.41Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
29.41Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
29.41Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
29.41Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
29.41Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.41Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.41Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
29.17Single4XT3Fractalkine4XT3-US28-Fractalkine
29.17Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.17Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Single3PWHZM-2413853PWH-A2A-ZM-241385
28.57Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
28.57Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
28.57Single5U09Taranabant5U09-CB1-Taranabant
28.57Single6AKXA4R6AKX-CCR5-A4R
28.57Single6AKYMaraviroc6AKY-CCR5-Maraviroc
28.57Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
28.57Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
28.57Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
28.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.57Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
28.57Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
28.57Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
28.57Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
28.57Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
28.57Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
28.57Consensusangiotensin_offOrthosteric Ligandat1_off
28.57Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.57Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
28.57Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
27.78Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
27.78Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.78Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
27.78Single7K15MKD0467K15-BLT1-MKD046-Na
27.78Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
27.78Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.78Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
27.78Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.78Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
27.78Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
27.78Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.78Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
27.78Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
27.78Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
27.78Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
27.78Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
27.78Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.78Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.27Single6W25SHU91196W25-MC4-SHU9119-Ca
27.27Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
27.27Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
27.27Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
27.27Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
27.27Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
27.27Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
27.27Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
27.27Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
27.27Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.27Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
27.27Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
27.27Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
26.92Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.92Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.67Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
26.67Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
26.67Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
26.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
26.67Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.67Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
26.67Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
26.67Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.67Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.67Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
26.67Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
26.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
26.67Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.32Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
26.32Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
26.32Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.32Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
26.32Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
26.32Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
26.32Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
26.32Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
26.32Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
26.32Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
26.32Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
26.32Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.32Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.32Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.32Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
26.32Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.32Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.32Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.32Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
26.09Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
26.09Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.09Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.09Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
26.09Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.09Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
26.09Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
26.09Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.09Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
26.09Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.09Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.09Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.09Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.09Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
26.09Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.09Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
25.93Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
25.93Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4QIMANTA XV4QIM-SMO-ANTA XV
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5ZTYAM102575ZTY-CB2-AM10257
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
25.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8RLNLUF58348RLN-A2A-LUF5834
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8T1WCVN4248T1W-GPR6-CVN424
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
25.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
25.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
25.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
25.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
25.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
25.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
24.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
24.00Single6FJ3PTH6FJ3-PTH1-PTH
24.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
24.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
24.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
23.81Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.81Single7F8XNN90567F8X-CCKA-NN9056
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
23.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8IEBA1LYA8IEB-GPR156-A1LYA
23.81Single8IEPA1LYA8IEP-GPR156-A1LYA
23.81Single8IEPA1LYA8IEP-GPR156-A1LYA
23.81Single8WKYPG-9348WKY-MC4-PG-934
23.81Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.81Single8XWNCXCL88XWN-CXCR2-CXCL8
23.81Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
23.81Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
23.81Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single4JKVTaladegib4JKV-SMO-Taladegib
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
23.53Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.53Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.53Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.53Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.53Single7C4SS1P7C4S-S1P3-S1P
23.53Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
23.53Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.53Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
23.53Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
23.53Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.53Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.53Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
23.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
23.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.53Single8S4DCMF-0198S4D-Apelin-CMF-019
23.53Single8TF5Oleic acid8TF5-GPR6-Oleic acid
23.53Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.53Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
23.53Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
23.53Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
23.53Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
23.53Consensusblt_offOrthosteric Ligandblt1_off
23.53Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.53Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
23.53Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
23.08Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
23.08Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
23.08Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
23.08Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.08Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
23.08Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
23.08Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
23.08Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
23.08Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
23.08Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
22.73Single3QAKUK-4320973QAK-A2A-UK-432097
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
22.73Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
22.73Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
22.73Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
22.73Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
22.73Single8IEBA1LYA8IEB-GPR156-A1LYA
22.73Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
22.73Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.73Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.73Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.73Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
22.73Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.73Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.73Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.73Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.22Single5V56TC1145V56-SMO-TC114
22.22Single5V57TC1145V57-SMO-TC114
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
22.22Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
22.22Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
22.22Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
22.22Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.22Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
22.22Single7PX4PSB-21137PX4-A2A-PSB-2113
22.22Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
22.22Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
22.22Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
22.22Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
22.22Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
22.22Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
22.22Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
22.22Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.22Single9BJKNAM9BJK-μ-Naloxone-NAM
22.22Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
22.22Consensusa2_onOrthosteric Liganda2b_on
22.22Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Consensusbradykinin_onOrthosteric Ligandbk2_on
22.22Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
22.22Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.22Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.22Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.74Single3OE0CVX153OE0-CXCR4-CVX15
21.74Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.74Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
21.74Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.74Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
21.74Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.74Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.74Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.74Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
21.74Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
21.74Consensusangiotensin_onOrthosteric Ligandat1_on
21.74Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.74Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.74Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
21.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.74Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.74Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.43Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.43Single6LI0C176LI0-GPR52-C17
21.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.43Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
21.43Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
21.43Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
21.43Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.43Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
21.43Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
21.43Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.43Single9B9Y7DY9B9Y-CB1-7DY
21.43Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.43Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
21.43Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.43Consensusgq_nucleotideOrthosteric Ligandgq_p2y
21.43Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.05Single4RWADIPP-NH24RWA-δ-DIPP-NH2
21.05Single5X33BIIL2605X33-BLT1-BIIL260
21.05Single6A93Risperidone6A93-5-HT2A-Risperidone
21.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.05Single6IIURamatroban6IIU-TP-Ramatroban
21.05Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
21.05Single6KQICP559406KQI-CB1-CP55940-Org27569
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6OS2TRV0266OS2-AT1-TRV026
21.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
21.05Single7DFPSpiperone7DFP-D2-Spiperone
21.05Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
21.05Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.05Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.05Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
21.05Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.05Single7YITNalfurafine7YIT-κ-Nalfurafine
21.05Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.05Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
21.05Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
21.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.05Single8JWY2-1188JWY-A2A-2-118
21.05Single8JWZAB9288JWZ-A2A-AB928-Na
21.05Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
21.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.05Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
21.05Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
21.05Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
21.05Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
21.05Consensusalpha1_offOrthosteric Ligandalpha1a_off
21.05Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
21.05Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.05Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.05Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.05Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.05Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.05Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.05Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
20.83Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.83Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
20.83Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.83Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
20.83Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.83Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.83Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
20.83Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.83Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.83Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.83Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
20.83Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.83Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.83Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.83Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Consensusvasop-oxy_onOrthosteric Ligandv2_on
20.83Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
20.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.00Single5WS3EMPA5WS3-OX2-EMPA
20.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
20.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
20.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
20.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
20.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
20.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
20.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
20.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
20.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
20.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
20.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
20.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
20.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
20.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
20.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XVUCXCL28XVU-CXCR2-CXCL2
20.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
20.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
20.00Single9BA0A1AKN9BA0-CB1-A1AKN
20.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
20.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
20.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
20.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
20.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
20.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
19.23Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
19.23Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
19.23Single7SK3CXCL127SK3-ACKR3-CXCL12
19.23Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
19.23Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.23Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
19.23Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
19.23Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
19.23Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
19.23Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.23Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.23Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.23Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
19.23Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.05Single3NY9ICI118-5513NY9-β2-ICI118-551
19.05Single4UG2CGS216804UG2-A2A-CGS21680
19.05Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
19.05Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
19.05Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.05Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
19.05Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
19.05Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
19.05Single8IEIA1LYA8IEI-GPR156-A1LYA
19.05Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
19.05Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
19.05Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
19.05Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single2YDOAdenosine2YDO-A2A-Adenosine
18.75Single3REYXAC3REY-A2A-XAC
18.75Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
18.75Single4ZJCSB-6740424ZJC-OX1-SB-674042
18.75Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5JTBZM-2413855JTB-A2A-ZM-241385
18.75Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.75Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
18.75Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.75Single6AQFZM-2413856AQF-A2A-ZM-241385
18.75Single6KUXRS-799486KUX-α2a-RS-79948
18.75Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
18.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
18.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
18.75Single6TP3Nemorexant6TP3-OX1-Nemorexant
18.75Single6TPGEMPA6TPG-OX2-EMPA
18.75Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
18.75Single6V9SGTPL114036V9S-OX1-GTPL11403
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
18.75Single6ZG9GSK10347026ZG9-M1-GSK1034702
18.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single7UL3Famotidine7UL3-H2-Famotidine
18.75Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
18.75Single7VV6C48/807VV6-MRGPRX2-C48/80
18.75Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
18.75Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
18.75Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
18.75Single8K2WAMG4878K2W-CXCR3-AMG487
18.75Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
18.75Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
18.75Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
18.75Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
18.75Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
18.75Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
18.75Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
18.75Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
18.75Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
18.75Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
18.75Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
18.75Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
18.75Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
18.75Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.75Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.52Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
18.52Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.52Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.52Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
18.52Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.52Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
18.52Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
18.18Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
18.18Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
18.18Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
18.18Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
18.18Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
18.18Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
18.18Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
18.18Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
18.18Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
18.18Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
18.18Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
18.18Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
18.18Single8IEIA1LYA8IEI-GPR156-A1LYA
18.18Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
18.18Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.18Single8WDTphotoNECA8WDT-A2A-photoNECA
18.18Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
18.18Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
18.18Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
18.18Consensuslpl_onOrthosteric Ligands1p_on lpa_on
18.18Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
18.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.18Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.18Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
17.86Single6IGLIRL16206IGL-ETB-IRL1620
17.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.86Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.65Single2Y02Carmoterol2Y02-β1-Carmoterol
17.65Single3EMLZM-2413853EML-A2A-ZM-241385
17.65Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
17.65Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.65Single4EJ4Naltrindole4EJ4-δ-Naltrindole
17.65Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
17.65Single5DHHSB-6121115DHH-NOP-SB-612111
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
17.65Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.65Single5TGZAM65385TGZ-CB1-AM6538
17.65Single5UIGCmpd-15UIG-A2A-Cmpd-1
17.65Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6DRXLisuride6DRX-5-HT2B-Lisuride
17.65Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
17.65Single6GPSMK08126GPS-CCR2-MK0812
17.65Single6IIVDaltroban6IIV-TP-Daltroban
17.65Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
17.65Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
17.65Single6S0LZM-2413856S0L-A2A-ZM-241385
17.65Single6TOTLemborexant6TOT-OX1-Lemborexant
17.65Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
17.65Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
17.65Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
17.65Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
17.65Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
17.65Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7UL4Alvimopan7UL4-μ-Alvimopan
17.65Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
17.65Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
17.65Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.65Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.65Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
17.65Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
17.65Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
17.65Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
17.65Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
17.65Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.65Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
17.65Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
17.65Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
17.65Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
17.65Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.65Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
17.65Single9CHXS-Carazolol9CHX-β2-S-Carazolol
17.65Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
17.65Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
17.65Consensusa3_onOrthosteric Liganda3a_on
17.65Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Consensusblt_onOrthosteric Ligandblt1_on
17.65Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
17.65Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
17.65Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
17.65Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.65Consensusleukotriene_onOrthosteric Ligandblt_on
17.65Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
17.39Single6HLOAprepitant6HLO-NK1-Aprepitant
17.39Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.39Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.39Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
17.39Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
17.39Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7SK5CXCL127SK5-ACKR3-CXCL12
17.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.39Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
17.39Single7XNACYN1548067XNA-SST2-CYN154806
17.39Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
17.39Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
17.39Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.39Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
17.39Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
17.39Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
17.39Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
17.39Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.39Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.24Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.24Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.24Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
17.24Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.24Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.24Consensusbombesin_onOrthosteric Ligandbb2_on
17.24Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.24Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
16.67Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
16.67Single5C1MBU725C1M-μ-BU72
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
16.67Single5N2RPSB-365N2R-A2A-PSB-36-Na
16.67Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
16.67Single5WF5UK-4320975WF5-A2A-UK-432097
16.67Single5WQCEMPA5WQC-OX2-EMPA
16.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
16.67Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
16.67Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
16.67Single6GPXMK08126GPX-CCR2-MK0812
16.67Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
16.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
16.67Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
16.67Single6PT2KGCHM076PT2-δ-KGCHM07
16.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
16.67Single6TP6Filorexant6TP6-OX1-Filorexant
16.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
16.67Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
16.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
16.67Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
16.67Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
16.67Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
16.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.67Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7WC6LSD7WC6-5-HT2A-LSD
16.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.67Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
16.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
16.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
16.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
16.67Single8JXSPF-61428JXS-D1-PF-6142
16.67Single8PWNTheophylline8PWN-A2A-Theophylline
16.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
16.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
16.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
16.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.67Consensusa3_on_gpOrthosteric Liganda3a_on_gp
16.67Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
16.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
16.67Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
16.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrace-amine_onOrthosteric Ligandta1_on
16.13Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.13Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
16.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
16.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
16.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
16.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
15.79Single2YDVNECA2YDV-A2A-NECA
15.79Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
15.79Single4DJHJDTic4DJH-κ-JDTic
15.79Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.79Single4UHRCGS216804UHR-A2A-CGS21680
15.79Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.79Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
15.79Single5G53NECA5G53-A2A-NECA-Gs
15.79Single5TZRMK86665TZR-FFA1-MK8666
15.79Single6J21Aprepitant6J21-NK1-Aprepitant
15.79Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
15.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.79Single6OS1TRV0266OS1-AT1-TRV026
15.79Single6TQ7SB-3348676TQ7-OX1-SB-334867
15.79Single6WGTLSD6WGT-5-HT2A-LSD
15.79Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
15.79Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.79Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
15.79Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
15.79Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.79Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
15.79Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
15.79Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.79Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
15.79Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
15.79Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
15.79Single8E0GBU728E0G-μ-BU72
15.79Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
15.79Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
15.79Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
15.79Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.79Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.79Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.79Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.79Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
15.79Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
15.79Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
15.79Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
15.79Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
15.79Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
15.79Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
15.79Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.79Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
15.79Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
15.79Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
15.79Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
15.79Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.79Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
15.79Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
15.79Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
15.79Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
15.79Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.79Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
15.79Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
15.79Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
15.79Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
15.79Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
15.79Consensuslpa_onOrthosteric Ligandlpa1_on
15.79Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
15.79Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.79Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.79Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
15.62Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single3RFMCaffeine3RFM-A2A-Caffeine
15.38Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
15.38Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
15.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
15.38Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.38Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
15.38Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
15.38Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
15.38Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.38Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.38Single8ZRTET-18ZRT-ETB-ET-1
15.38Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.38Single9CHUNoradrenaline9CHU-β2-Noradrenaline
15.38Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.00Single4AMIBucindolol4AMI-β1-Bucindolol
15.00Single4N4WSANT-14N4W-SMO-SANT-1
15.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
15.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
15.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
15.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.00Single6MXTSalmeterol6MXT-β2-Salmeterol
15.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
15.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
15.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
15.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
15.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
15.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
15.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
15.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
15.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
15.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
15.00Single8JJLOlodaterol8JJL-β2-Olodaterol
15.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
15.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
15.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
15.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
15.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
15.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.00Single8XWACXCL18XWA-CXCR2-CXCL1
15.00Single8XWMCXCL68XWM-CXCR2-CXCL6
15.00Single8XWSCXCL58XWS-CXCR2-CXCL5
15.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
15.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
15.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
15.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
15.00Consensuslpa_offOrthosteric Ligandlpa1_off
15.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
15.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
15.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
15.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.00Consensusorexin_onOrthosteric Ligandox2_on
14.81Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
14.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
14.81Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.81Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.81Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
14.81Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
14.29Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
14.29Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
14.29Single3UZAGTPL92363UZA-A2A-GTPL9236
14.29Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
14.29Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29Single5X93K-87945X93-ETB-K-8794
14.29Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
14.29Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
14.29Single6IBLArformoterol6IBL-β1-Arformoterol
14.29Single6ME5Agomelatine6ME5-MT1-Agomelatine
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
14.29Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
14.29Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
14.29Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
14.29Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
14.29Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
14.29Single7EZCUKA7EZC-A2A-UKA
14.29Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
14.29Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
14.29Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
14.29Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
14.29Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
14.29Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.29Single7WC5Psilocin7WC5-5-HT2A-Psilocin
14.29Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
14.29Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
14.29Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
14.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.29Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
14.29Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
14.29Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
14.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
14.29Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
14.29Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.29Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
14.29Single8XWFCXCL38XWF-CXCR2-CXCL3
14.29Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
14.29Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
14.29Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
14.29Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.29Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensus5ht2_onOrthosteric Ligand5ht2b_on
14.29Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
14.29Consensuschemerin_onOrthosteric Ligandcml1_on
14.29Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
14.29Consensusendothelin_offOrthosteric Ligandetb_off
14.29Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusgi_sensoryOrthosteric Ligandgi_opsins
14.29Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.29Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.29Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.29Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
13.79Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
13.79Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
13.79Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.79Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.64Single5WF6UK-4320975WF6-A2A-UK-432097
13.64Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
13.64Single6PT3DPI-2876PT3-δ-DPI-287
13.64Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.64Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
13.64Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.64Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
13.64Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
13.64Single7XN9L-054,5227XN9-SST2-L-054,522
13.64Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
13.64Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.64Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
13.64Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.64Single8X5YAstemizole8X5Y-H1-Astemizole
13.64Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.64Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.64Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
13.64Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.64Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
13.33Single6HLLCP999946HLL-NK1-CP99994
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
13.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
13.33Single7SRQLSD7SRQ-5-HT2B-LSD
13.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
13.33Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
13.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
13.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
13.33Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.33Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.33Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
13.33Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
13.33Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
13.33Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
13.33Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
13.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
13.04Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.04Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
13.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
13.04Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
13.04Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
13.04Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.04Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
13.04Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.04Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.04Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
13.04Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
13.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Consensussomatostatin_offOrthosteric Ligandsst2_off
12.90Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.90Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.90Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.90Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.90Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
12.50Single6B73MP11046B73-κ-MP1104
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
12.50Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.50Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6TODEMPA6TOD-OX1-EMPA-Na
12.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
12.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
12.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
12.50Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.50Single7F8ULintitript7F8U-CCKA-Lintitript
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.50Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
12.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
12.50Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
12.50Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.50Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
12.50Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
12.50Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
12.50Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
12.50Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
12.50Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
12.50Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
12.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.50Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
12.50Single8IWESpermidine8IWE-TA9-Spermidine
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
12.50Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
12.50Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
12.50Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
12.50Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
12.50Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
12.50Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
12.50Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
12.50Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusalpha2_offOrthosteric Ligandalpha2c_off
12.50Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.50Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.50Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.50Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
12.12Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
12.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
12.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
12.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
11.76Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.76Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
11.76Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
11.76Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.76Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
11.76Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
11.76Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
11.76Single5UVIZM-2413855UVI-A2A-ZM-241385
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6IQLL7458706IQL-D4-L745870
11.76Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
11.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.76Single6PS0S-Carazolol6PS0-β2-S-Carazolol
11.76Single6PS4ICI118-5516PS4-β2-ICI118-551
11.76Single6PS5S-Propranolol6PS5-β2-S-Propranolol
11.76Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
11.76Single6TPKRetosiban6TPK-OT-Retosiban
11.76Single6VI4JDTic6VI4-κ-JDTic
11.76Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
11.76Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
11.76Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
11.76Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
11.76Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.76Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
11.76Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
11.76Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
11.76Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
11.76Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
11.76Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7T32ZM-2413857T32-A2A-ZM-241385
11.76Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
11.76Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
11.76Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
11.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.76Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
11.76Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
11.76Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
11.76Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
11.76Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
11.76Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
11.76Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
11.76Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
11.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.76Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
11.76Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
11.76Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
11.76Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
11.76Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
11.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
11.76Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
11.76Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.76Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
11.76Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Consensusgrh_offOrthosteric Ligandgnrh1_off
11.76Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
11.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.76Consensusopsins_offOrthosteric Ligandrhodopsin_off
11.76Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
11.76Consensussensory_offOrthosteric Ligandopsins_off
11.76Consensusvasop-oxy_offOrthosteric Ligandot_off
11.54Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.54Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.54Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.54Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.54Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
11.11Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.11Single2Y01Dobutamine2Y01-β1-Dobutamine
11.11Single2Y04Salbutamol2Y04-β1-Salbutamol
11.11Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.11Single3NY8ICI118-5513NY8-β2-ICI118-551
11.11Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
11.11Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.11Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.11Single4DAJTiotropium4DAJ-M3-Tiotropium
11.11Single4GBRS-Carazolol4GBR-β2-S-Carazolol
11.11Single4MQSIperoxo4MQS-M2-Iperoxo
11.11Single4QKX35V4QKX-β2-35V
11.11Single4U14Tiotropium4U14-M3-Tiotropium
11.11Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
11.11Single5DHGC-355DHG-NOP-C-35
11.11Single5T04Neurotensin5T04-NTS1-Neurotensin
11.11Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
11.11Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
11.11Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6H7MSalbutamol6H7M-β1-Salbutamol
11.11Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
11.11Single6PS1Timolol6PS1-β2-Timolol
11.11Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
11.11Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
11.11Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
11.11Single7BU7BI1671077BU7-β1-BI167107
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.11Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
11.11Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.11Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
11.11Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.11Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
11.11Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
11.11Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.11Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
11.11Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
11.11Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.11Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
11.11Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
11.11Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.11Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
11.11Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
11.11Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
11.11Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
11.11Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
11.11Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
11.11Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
11.11Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
11.11Single8JJOAlprenolol8JJO-β2-Alprenolol
11.11Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.11Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
11.11Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
11.11Single8JXRLSD8JXR-D1-LSD
11.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.11Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
11.11Single8X63Mepyramine8X63-H1-Mepyramine
11.11Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
11.11Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
11.11Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.11Consensus5ht5_onOrthosteric Ligand5ht5a_on
11.11Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.11Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
11.11Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
11.11Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.11Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.11Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
11.11Consensusalpha2_onOrthosteric Ligandalpha2b_on
11.11Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
11.11Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
11.11Consensuscck_offOrthosteric Ligandccka_off
11.11Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.11Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
11.11Consensusdopamine_offOrthosteric Ligandd2_off d3_off
11.11Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
11.11Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
11.11Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
11.11Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
11.11Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.11Consensushistamine_offOrthosteric Ligandh1_off
11.11Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.11Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
11.11Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
11.11Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
10.81Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.53Single2RH1S-Carazolol2RH1-β2-S-Carazolol
10.53Single2Y00Dobutamine2Y00-β1-Dobutamine
10.53Single2Y03Isoprenaline2Y03-β1-Isoprenaline
10.53Single2YCWS-Carazolol2YCW-β1-S-Carazolol
10.53Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.53Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.53Single5CGCHTL142425CGC-mGlu5-HTL14242
10.53Single5D6LS-Carazolol5D6L-β2-S-Carazolol
10.53Single5JQHS-Carazolol5JQH-β2-S-Carazolol
10.53Single5TVNLSD5TVN-5-HT2B-LSD
10.53Single5WIUNemonapride5WIU-D4-Nemonapride
10.53Single5WIVNemonapride5WIV-D4-Nemonapride-Na
10.53Single5XPRBosentan5XPR-ETB-Bosentan
10.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.53Single6E67BI1671076E67-β2-BI167107-Gs (fused)
10.53Single6HLPNetupitant6HLP-NK1-Netupitant
10.53Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
10.53Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.53Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
10.53Single6PS6Timolol6PS6-β2-Timolol
10.53Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.53Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.53Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
10.53Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
10.53Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.53Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.53Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
10.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
10.53Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
10.53Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
10.53Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
10.53Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.53Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
10.53Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.53Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
10.53Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
10.53Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
10.53Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.53Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
10.53Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
10.53Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.53Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
10.53Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
10.53Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
10.53Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
10.53Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
10.53Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
10.53Consensusamine_offonOrthosteric Ligandamine_off amine_on
10.53Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
10.53Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
10.53Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
10.53Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
10.53Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.53Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.53Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
10.53Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.53Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
10.53Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.00Single3P0GBI1671073P0G-β2-BI167107
10.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
10.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
10.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
10.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
10.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
10.00Single4U15Tiotropium4U15-M3-Tiotropium
10.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
10.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
10.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
10.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
10.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
10.00Single6E59L-7607356E59-NK1-L-760735
10.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
10.00Single6J20Aprepitant6J20-NK1-Aprepitant
10.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
10.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
10.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.00Single6OL9Tiotropium6OL9-M5-Tiotropium
10.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
10.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
10.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
10.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
10.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
10.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
10.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
10.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
10.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
10.00Single8EA0Iperoxo8EA0-M3-Iperoxo
10.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
10.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
10.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
10.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.00Single8XVLZibotentan8XVL-ETA-Zibotentan
10.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
10.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
10.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
10.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
10.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
10.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
10.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
10.00Consensusneurotensin_onOrthosteric Ligandnts1_on
10.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Consensustachykinin_offOrthosteric Ligandnk1_off
9.68Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.68Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.68Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
9.52Single3D4STimolol3D4S-β2-Timolol
9.52Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
9.52Single4LDEBI1671074LDE-β2-BI167107
9.52Single4XEENeurotensin4XEE-NTS1-Neurotensin
9.52Single4XESNeurotensin4XES-NTS1-Neurotensin
9.52Single5CXVTiotropium5CXV-M1-Tiotropium
9.52Single6CM4Risperidone6CM4-D2-Risperidone
9.52Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
9.52Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single6YVRNTS8-136YVR-NTS1-NTS8-13
9.52Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
9.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.52Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.52Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
9.52Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
9.52Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
9.52Single8JJ8Formoterol8JJ8-β2-Formoterol
9.52Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8XQJJN2418XQJ-Apelin-JN241
9.52Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
9.52Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
9.52Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
9.52Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.52Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
9.52Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
9.52Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.09Single5CGDHTL142425CGD-mGlu5-HTL14242
9.09Single6H7LDobutamine6H7L-β1-Dobutamine
9.09Single6K1QIRL25006K1Q-ETB-IRL2500
9.09Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
9.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
9.09Single8XVJMacitentan8XVJ-ETA-Macitentan
9.09Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.09Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
9.09Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
9.09Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.09Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.70Single6KNMJN241-96KNM-Apelin-JN241-9
8.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.70Single8XQJJN2418XQJ-Apelin-JN241
8.70Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.70Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
8.57Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
8.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
7.69Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
7.69Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
7.69Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
7.69Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
7.41Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.41Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
7.14Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.14Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.14Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
7.14Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.14Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.14Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
7.14Consensusp2y_offOrthosteric Ligandp2y1_off
7.14Consensussensory_onOrthosteric Ligandopsins_on
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
6.67Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single4XNWMRS25004XNW-P2Y1-MRS2500
6.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.67Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
6.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
6.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.67Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
6.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.67Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
6.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.67Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
6.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
6.67Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.45Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
6.25Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
6.25Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
6.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
6.25Single3PBLEticlopride3PBL-D3-Eticlopride
6.25Single4O9RCyclopamine4O9R-SMO-Cyclopamine
6.25Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
6.25Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.25Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
6.25Single7UL2SR486927UL2-NTS1-SR48692-Na
6.25Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.25Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
6.25Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
6.25Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.25Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.25Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.25Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
6.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.25Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.25Consensusneurotensin_offOrthosteric Ligandnts1_off
6.25Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.88Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.88Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
5.88Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.88Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.88Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.88Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
5.88Single4QINSAG1.54QIN-SMO-SAG1.5
5.88Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.88Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.88Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.88Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.88Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.88Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.88Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
5.88Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
5.88Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
5.88Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
5.88Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
5.88Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
5.88Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.88Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.88Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.88Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.88Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.88Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.88Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
5.88Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
5.56Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
5.56Single3RZECidoxepin3RZE-H1-Cidoxepin
5.56Single6A94Zotepine6A94-5-HT2A-Zotepine
5.56Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.56Single6TPNHTL66416TPN-OX2-HTL6641
5.56Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
5.56Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
5.56Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
5.56Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
5.56Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.56Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.56Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
5.56Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
5.56Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
5.56Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.56Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
5.56Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
5.56Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.56Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
5.56Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
5.26Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
5.26Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.26Single5DSGTiotropium5DSG-M4-Tiotropium
5.26Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.26Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
5.26Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.26Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.26Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.26Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
5.26Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.26Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.26Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
5.26Single8X64Desloratadine8X64-H1-Desloratadine
5.26Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.26Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
5.26Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.26Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
5.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
5.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
5.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.00Single6Z4SSR486926Z4S-NTS1-SR48692
5.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
5.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
5.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
5.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.76Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
4.76Single7P2L4YI7P2L-mGlu5-4YI
4.76Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.76Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.55Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
4.55Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.17Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.17Consensuskisspeptin_onOrthosteric Ligandkiss1_on
4.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp

PDB Summary
PDB 5ZKQ
Class A
SubFamily Lipid
Type Platelet Activating Factor
SubType PAF
Species Homo Sapiens
Ligand ABT-491
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.9
Date 2018-06-20
D.O.I. 10.1038/s41594-018-0068-y
Net Summary
Imin 4.36
Number of Linked Nodes 266
Number of Links 306
Number of Hubs 47
Number of Links mediated by Hubs 164
Number of Communities 9
Number of Nodes involved in Communities 48
Number of Links involved in Communities 62
Path Summary
Number Of Nodes in MetaPath 64
Number Of Links MetaPath 63
Number of Shortest Paths 60076
Length Of Smallest Path 3
Average Path Length 13.6819
Length of Longest Path 37
Minimum Path Strength 1.425
Average Path Strength 8.54705
Maximum Path Strength 26.625
Minimum Path Correlation 0.7
Average Path Correlation 0.927171
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 51.9901
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.0453
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• hydrolase activity, acting on glycosyl bonds   • peptidoglycan muralytic activity   • hydrolase activity, hydrolyzing O-glycosyl compounds   • lysozyme activity   • hydrolase activity   • catalytic activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • binding   • lipid binding   • lipopolysaccharide binding   • carbohydrate derivative binding   • platelet activating factor receptor activity   • phospholipid binding   • pattern recognition receptor activity   • lipopolysaccharide immune receptor activity   • protein binding   • kinase binding   • enzyme binding   • protein kinase binding   • mitogen-activated protein kinase binding   • G protein-coupled purinergic nucleotide receptor activity   • purinergic nucleotide receptor activity   • nucleotide receptor activity   • biological process involved in interspecies interaction between organisms   • response to stimulus   • response to other organism   • defense response   • response to external stimulus   • response to biotic stimulus   • defense response to bacterium   • defense response to other organism   • response to stress   • response to bacterium   • response to external biotic stimulus   • carbohydrate derivative catabolic process   • catabolic process   • peptidoglycan catabolic process
Gene OntologyBiological Process• biological process involved in interspecies interaction between organisms   • response to stimulus   • response to other organism   • defense response   • response to external stimulus   • response to biotic stimulus   • defense response to bacterium   • defense response to other organism   • response to stress   • response to bacterium   • response to external biotic stimulus   • carbohydrate derivative catabolic process   • catabolic process   • peptidoglycan catabolic process   • glycosaminoglycan metabolic process   • carbohydrate derivative metabolic process   • aminoglycan catabolic process   • macromolecule catabolic process   • glycosaminoglycan catabolic process   • aminoglycan metabolic process   • peptidoglycan metabolic process   • metabolic process   • cellular process   • macromolecule metabolic process   • symbiont-mediated cytolysis of host cell   • viral life cycle   • disruption of cell in another organism   • cytolysis   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • viral release from host cell by cytolysis   • exit from host cell   • viral process   • cytolysis in another organism   • viral release from host cell   • disruption of anatomical structure in another organism   • symbiont-mediated killing of host cell   • killing of cells of another organism   • cell killing   • cell wall organization or biogenesis   • cell wall macromolecule catabolic process   • cell wall macromolecule metabolic process   • positive regulation of locomotion   • regulation of cell motility   • regulation of cellular process   • positive regulation of biological process   • positive regulation of cell migration   • positive regulation of cell motility   • regulation of cell migration   • cellular extravasation   • cell migration   • regulation of immune system process   • cell motility   • positive regulation of immune system process   • locomotion   • positive regulation of cellular process   • regulation of biological process   • regulation of leukocyte migration   • biological regulation   • positive regulation of leukocyte migration   • leukocyte migration   • immune system process   • regulation of locomotion   • positive regulation of cellular extravasation   • regulation of cellular extravasation   • immune response   • interleukin-6 production   • multicellular organismal process   • positive regulation of macromolecule biosynthetic process   • positive regulation of interleukin-6 production   • regulation of interleukin-6 production   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • regulation of macromolecule biosynthetic process   • positive regulation of cytokine production   • regulation of metabolic process   • multi-multicellular organism process   • reproductive process   • parturition   • multi-organism reproductive process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to organophosphorus   • response to oxygen-containing compound   • response to nitrogen compound   • response to purine-containing compound   • response to cAMP   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • cellular response to cAMP   • chemotaxis   • taxis   • positive regulation of protein metabolic process   • positive regulation of translation   • regulation of primary metabolic process   • post-transcriptional regulation of gene expression   • protein metabolic process   • regulation of protein metabolic process   • primary metabolic process   • translation   • regulation of translation   • regulation of reproductive process   • multicellular organismal reproductive process   • positive regulation of maternal process involved in parturition   • maternal process involved in parturition   • regulation of maternal process involved in parturition   • positive regulation of reproductive process   • response to ketone   • response to lipid   • response to endogenous stimulus   • response to glucocorticoid   • response to corticosteroid   • response to hormone   • response to steroid hormone   • response to dexamethasone   • positive regulation of leukocyte cell-cell adhesion   • regulation of leukocyte adhesion to vascular endothelial cell   • leukocyte cell-cell adhesion   • leukocyte tethering or rolling   • positive regulation of cell-cell adhesion   • cell adhesion   • cell-cell adhesion   • positive regulation of leukocyte tethering or rolling   • regulation of cell-cell adhesion   • positive regulation of cell adhesion   • regulation of cell adhesion   • positive regulation of leukocyte adhesion to vascular endothelial cell   • regulation of leukocyte tethering or rolling   • leukocyte adhesion to vascular endothelial cell   • regulation of leukocyte cell-cell adhesion   • regulation of localization   • regulation of transcytosis   • transport   • regulation of transport   • positive regulation of transcytosis   • regulation of vesicle-mediated transport   • establishment of localization   • vesicle-mediated transport   • localization   • positive regulation of transport   • transcytosis   • response to symbiont   • response to symbiotic bacterium   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine   • response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine   • cellular response to ether   • response to ether   • cellular response to lipid   • cell population proliferation   • regulation of smooth muscle cell proliferation   • positive regulation of cell population proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • inflammatory response   • RNA metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • regulation of DNA-templated transcription   • response to fatty acid   • cellular response to fatty acid   • regulation of tumor necrosis factor production   • positive regulation of tumor necrosis factor superfamily cytokine production   • tumor necrosis factor superfamily cytokine production   • positive regulation of tumor necrosis factor production   • tumor necrosis factor production   • regulation of tumor necrosis factor superfamily cytokine production   • polyol metabolic process   • small molecule biosynthetic process   • inositol trisphosphate biosynthetic process   • alcohol metabolic process   • inositol phosphate metabolic process   • organophosphate metabolic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • phosphate-containing compound metabolic process   • polyol biosynthetic process   • alcohol biosynthetic process   • inositol trisphosphate metabolic process   • small molecule metabolic process   • phosphorus metabolic process   • regulation of immune effector process   • neutrophil activation   • regulation of myeloid leukocyte mediated immunity   • positive regulation of leukocyte mediated immunity   • regulated exocytosis   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte mediated immunity   • myeloid leukocyte activation   • neutrophil activation involved in immune response   • positive regulation of leukocyte degranulation   • positive regulation of regulated secretory pathway   • positive regulation of immune response   • establishment of localization in cell   • leukocyte mediated immunity   • immune effector process   • regulation of secretion   • regulation of leukocyte mediated immunity   • exocytosis   • regulation of response to stimulus   • positive regulation of myeloid leukocyte mediated immunity   • regulation of immune response   • cellular localization   • positive regulation of secretion by cell   • positive regulation of exocytosis   • leukocyte activation   • regulation of regulated secretory pathway   • positive regulation of response to stimulus   • neutrophil mediated immunity   • secretion by cell   • regulation of secretion by cell   • positive regulation of secretion   • regulation of neutrophil degranulation   • leukocyte activation involved in immune response   • neutrophil degranulation   • positive regulation of immune effector process   • regulation of leukocyte degranulation   • secretion   • cell activation   • export from cell   • myeloid cell activation involved in immune response   • regulation of exocytosis   • positive regulation of neutrophil degranulation   • granulocyte activation   • regulation of inositol phosphate biosynthetic process   • positive regulation of phosphate metabolic process   • regulation of small molecule metabolic process   • regulation of phosphate metabolic process   • regulation of carbohydrate metabolic process   • carbohydrate metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • carbohydrate biosynthetic process   • positive regulation of inositol phosphate biosynthetic process   • regulation of phosphorus metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • system process   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • negative regulation of blood pressure   • blood circulation   • gastro-intestinal system smooth muscle contraction   • positive regulation of smooth muscle contraction   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • positive regulation of gastro-intestinal system smooth muscle contraction   • regulation of gastro-intestinal system smooth muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • positive regulation of muscle contraction   • response to abiotic stimulus   • cellular response to gravity   • response to gravity   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • host cellular component   • host intracellular part   • cellular anatomical structure   • host cell cytoplasm   • host cell part   • host intracellular region   • membrane-bounded organelle   • intracellular anatomical structure   • tertiary granule membrane   • membrane   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • tertiary granule
Gene OntologyCellular Component• host cellular component   • host intracellular part   • cellular anatomical structure   • host cell cytoplasm   • host cell part   • host intracellular region   • membrane-bounded organelle   • intracellular anatomical structure   • tertiary granule membrane   • membrane   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • tertiary granule   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • organelle membrane   • secretory granule membrane   • cell periphery   • plasma membrane
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code9EU
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code9EU
Name4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide
Synonyms
Identifier
FormulaC28 H22 F N5 O2
Molecular Weight479.505
SMILES
PubChem154087
Formal Charge0
Total Atoms58
Total Chiral Atoms0
Total Bonds62
Total Aromatic Bonds26

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25105
Sequence
>5ZKQ_Chain_R
SHMDSEFRY TLFPIVYSI IFVLGVIAN GYVLWVFAR LYPFNEIKI 
FMVNLTMAD MLFLITLPL WIVYYQNQG NWILPKFLC NVAGCLFFI 
NTYCSVAFL GVITYNRYQ AVTRPIQAN TRKRGISLS LVIWVAIVG 
AASYFLILD STNTVPDSA GSGDVTRCF EHYEKGSVP VLIIHIFIV 
FSFFLVFLI ILFCNLVII RTLLMQPVA EVKRRDLWM ACTVLAVFI 
ICFVPHHVV QLPWTLAEL GFQDSKFHQ AINDAHQVT LCLLSTNCV 
LNPVIYCFL TKKF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
paf_off5ZKQ-PAF-ABT-491

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XYDALipidPlatelet Activating FactorPAFHomo sapiensPlatelet Activating Factor-Gi1/β1/γ22.92024-11-1310.1016/j.celrep.2024.114422
5ZKQALipidPlatelet Activating FactorPAFHomo sapiensABT-491--2.92018-06-2010.1038/s41594-018-0068-y
5ZKPALipidPlatelet Activating FactorPAFHomo sapiensForopafant (SR27417)--2.812018-06-2010.1038/s41594-018-0068-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ZKQ.zip



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