Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 2.15271402
2G.HN.30 1.41583407
3G.S1.02 5.31104445
4G.H1.01 5.55417449
5G.S2.01 4.92812419
6G.S2.08 7.32833445
7G.S3.01 5.39021444
8G.S3.03 7.01194647
9G.S3.04 7.62333516
10G.S3.05 3.92467547
11G.S3.06 7.77792615
12G.s3h2.03 5.13729419
13G.H2.06 6.19617519
14G.H2.07 5.94929719
15G.h2s4.01 7.4815519
16G.h2s4.02 5.52625417
17G.S4.02 4.46518
18G.s4h3.04 6.412598
19G.s4h3.14 2.40771406
20G.H3.01 6.11583509
21G.H3.03 3.45167494
22G.H3.06 4.92646406
23G.H3.09 6.49643719
24G.H3.13 4.44792615
25G.H3.17 8.62361615
26G.H3.18 5.1505519
27G.S5.04 4.77383519
28G.S5.05 3.80833859
29G.S5.07 3.8135559
30G.HG.07 3.641599
31G.HG.15 4.93479407
32G.hgh4.01 4.83833496
33G.hgh4.02 5.36611697
34G.hgh4.05 6.5545507
35G.H4.03 6.42417404
36G.H4.12 6.94896415
37G.H4.15 7.17625418
38G.S6.02 8.66604407
39G.S6.05 6.2775404
40G.s6h5.01 6.44458459
41G.s6h5.02 3.22396407
42G.H5.03 6.84583458
43G.H5.08 6.79548
44G.H5.13 8.30062408
45G.H5.26 5.84375405
46b.1x1 1.68983504
47b.1x4 2.46667508
48b.1x11 3.55755208
49b.h2x1 4.59063405
50b.b1x4 3.3235117
51b.b1x6 8.66396409
52b.l1x3 7.40702769
53b.l1x6 10.681419
54b.b2x1 7.84667618
55b.b2x5 6.75917667
56b.b3x3 4.55483578
57b.l3x1 7.65083419
58b.l3x2 5.30767569
59b.b4x2 5.18542408
60b.b4x3 5.463577
61b.b4x5 4.52708477
62b.b4x6 10.3663669
63b.l4x3 4.818334186
64b.b5x2 6.284794187
65b.b5x3 6.81986669
66b.b5x5 6.00021475
67b.b5x7 6.82625407
68b.l5x1 5.13521478
69b.l5x2 3.45875406
70b.l5x5 9.27694619
71b.b6x5 4.92556676
72b.l6x5 6.629794144
73b.b7x1 6.1985144
74b.b7x2 4.88478
75b.l7x2 4.57354419
76b.b8x1 3.85458418
77b.b8x3 4.78854406
78b.b8x4 6.15083576
79b.l8x5 2.56483503
80b.b9x4 7.325409
81b.l9x3 8.02767519
82b.l9x6 5.48417918
83b.l9x7 4.05083417
84b.b10x5 4.78486609
85b.b11x4 5.8335519
86b.l11x2 8.20312419
87b.b12x3 4.01833438
88b.b12x6 10.3243518
89b.b13x7 8.40833537
90b.l13x3 7.68792639
91b.l13x6 6.55813419
92b.b14x3 5.2875435
93b.b15x1 7.03653639
94b.b15x2 7.36229416
95b.l15x1 5.36729417
96b.l15x2 6.23917439
97b.b16x4 11.4756436
98b.b16x5 5.342505
99b.b16x6 8.99638
100b.b16x7 6.409584159
101b.b17x2 4.537714153
102b.b17x5 7.19062417
103b.b17x7 8.82875418
104b.l17x3 7.82095719
105b.l17x6 6.9325519
106b.b18x3 4.06625418
107b.b18x5 5.31633505
108b.l18x1 5.855717106
109b.l18x2 5.247924107
110b.b19x2 7.54792616
111b.b19x4 6.82792418
112b.l19x2 6.46617519
113b.b20x4 10.3837518
114b.b20x6 7.3325616
115b.b20x7 4.59875409
116b.b21x1 8.78854417
117b.b21x2 3.225406
118b.b21x5 5.83458404
119b.b21x7 7.86667505
120b.l21x2 5.88083404
121b.b22x5 5.064057107
122b.l22x5 7.1445219
123b.b23x1 4.00771405
124b.b23x2 5.462714106
125b.b23x6 7.82756167
126b.l23x1 7.36896416
127b.b24x4 7.231044166
128b.b24x6 7.235634168
129b.l24x2 5.24375406
130b.l24x3 3.59938405
131b.l25x3 9.34455139
132b.l25x6 13.5885418
133b.l27x1 10.3482819
134b.l27x2 7.108544139
135b.b28x3 5.025407
136b.b28x4 9.54254136
137b.b28x6 8.791835139
138g.h1x10 3.93896439
139g.h2x11 7.061254106
140g.h2x15 4.67771406
141g.ctx3 6.884835229
142g.ctx5 3.758964229
143g.ctx6 4.39708406
144g.ctx14 4.517714119
145g.ctx15 5.735834119
146g.ctx16 3.994698118
147NT 7.61102925
1481x42 3.20687406
1491x50 4.62292409
1501x60 3.49042407
1512x40 6.648476128
1522x42 5.41604408
1532x46 4.244589
1542x50 5.39483589
1552x57 5.74181626
1562x61 5.27264626
1572x64 8.76875423
1582x65 5.639524
1592x66 3.33813404
160E1 5.39347624
1613x33 5.38521424
1623x36 4.55633526
1633x44 4.06187406
1643x49 6.559384199
1653x50 6.95517589
166I2x53 6.962175197
1674x46 3.626884238
1684x50 5.103334239
169E2 14.60861925
1705x39 8.20396427
1715x43 8.38967525
1725x50 2.89021407
1735x51 4.51333427
1745x58 5.79486689
1755x60 6.77855245
176I3 2.79729453
1776x30 3.57104407
1786x48 4.55107728
179E3 5.87875421
1807x32 3.11833422
1817x34 6.80667424
1827x52 3.81063489
1837x53 5.23333789
1848x50 4.180834128
185Lig 8.164821420
186H.HA.19 0.3395834170
187H.HC.03 0.1665170
188H.HC.07 0.2733334170
189H.HD.07 0.382083400
190H.hdhe.01 0.304861600
191H.HE.05 0.2915500
192H.HE.06 0.357708400
193H.HF.06 0.495625400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l1x3 b.l3x2 15.65343.465YesYes699
2b.b4x2 b.l3x2 16.40096.5675YesYes089
3b.b4x6 b.l1x3 10.60393.79YesYes699
4b.b4x2 b.b5x8 17.12933.48667YesNo085
5b.b5x7 b.b5x8 17.2523.39YesNo075
6b.b4x3 b.b5x7 19.27788.5625YesYes077
7b.b3x3 b.b4x3 12.32883.47667YesYes787
8b.b3x3 b.b6x5 12.81855.36333YesYes786
9b.b2x4 b.b6x5 25.46683.27NoYes066
10b.b10x4 b.b2x4 25.49714.105NoNo066
11b.b10x2 b.b10x4 23.15524.87333NoNo066
12b.b10x2 b.b14x3 23.19234.36333NoYes065
13b.b11x5 b.b14x3 29.09036.3825NoYes065
14b.b10x1 b.b11x5 36.594.075NoNo096
15b.b10x1 b.l9x6 36.63163.39083NoYes098
16G.H2.07 b.l9x6 39.73016.11083YesYes198
17b.b4x3 b.b7x2 12.25713.22833YesYes778
18b.b6x5 b.b7x2 12.45644.1YesYes768
19G.H2.04 G.H2.07 39.32054.75NoYes099
20G.H2.04 G.H3.08 39.30995.16167NoNo099
21G.H3.08 G.S4.04 39.3136.1925NoNo099
22G.S4.04 G.S5.04 36.39783.85417NoYes199
23G.S5.04 G.S5.06 44.33475.76583YesNo098
24G.S5.06 G.s4h3.01 44.44615.19NoNo087
25G.HG.04 G.s4h3.01 44.044310.4617NoNo097
26G.HG.04 G.s4h3.04 44.01985.86583NoYes098
27G.HG.07 G.s4h3.04 1006.76583YesYes998
28G.HG.03 G.HG.07 99.2723.29NoYes069
29G.HG.03 G.s4h3.02 99.18926.13333NoNo069
30G.s4h3.02 G.s5hg.01 99.10625.4825NoNo099
31G.S5.07 G.s5hg.01 96.84642.33333YesNo099
32G.H1.04 G.S5.07 47.47125.07583NoYes579
33G.H1.04 G.S5.05 47.40423.34917NoYes579
34G.S4.03 G.S5.05 81.25873.4525NoYes579
35G.S1.04 G.S4.03 81.03916.77917NoNo077
36G.S1.04 G.S3.03 77.09933.55NoYes077
37G.S5.07 G.s6h5.01 48.87045.2375YesYes599
38G.S5.05 G.s6h5.01 47.36575.945YesYes599
39G.S3.01 G.S3.03 72.92756.99333YesYes447
40G.H3.18 G.S4.02 53.33776.46833YesYes198
41G.S3.01 I2x51 72.95435.65YesNo047
42G.H2.06 b.l9x6 13.35823.58YesYes198
43G.H2.06 b.l17x6 13.10019.2175YesYes199
44G.H3.17 b.l25x6 48.76638.91417YesYes158
45b.l23x1 b.l25x6 51.705117.5708YesYes168
46b.l21x7 b.l23x1 51.09664.79917NoYes056
47b.l21x7 b.l23x2 50.47788.4275NoNo058
48b.b23x6 b.l23x2 49.23144.3125YesNo078
49b.b23x6 b.b24x6 45.43648.28083YesYes1678
50b.b21x7 b.b24x6 44.903711.9783YesYes058
51b.b21x5 b.b21x7 34.020810.1767YesYes045
52b.b21x5 b.h2x1 32.1987.42YesYes045
53b.h2x1 b.h2x5 29.46783.9325YesNo055
54b.h2x5 b.l24x2 28.55965.28167NoYes056
55b.l22x5 b.l24x2 27.65139.61583YesYes096
56b.l22x5 g.ctx6 24.33144.555YesYes096
57g.ctx3 g.ctx6 21.49658.7075YesYes096
58G.S5.03 G.S5.05 12.73893.87167NoYes089
59G.S4.02 G.S5.02 61.63723.32917YesNo186
60G.H3.09 G.H4.15 28.69147.58917YesYes198
61G.HG.15 G.hgh4.02 19.79713.94917YesYes077
62G.H3.06 G.hgh4.02 39.94615.69833YesYes067
63G.H3.06 G.H4.15 30.07427.19583YesYes068
64G.H3.06 G.h4s6.01 28.97573.18417YesNo064
65G.H3.09 G.h4s6.01 28.59275.31417YesNo094
66G.hgh4.01 G.hgh4.02 18.7996.11417YesYes967
67G.H3.03 G.H3.06 19.08663.6275YesYes046
68G.H3.03 G.hgh4.01 18.63563.195YesYes946
69G.H3.15 G.H3.17 51.88363.6725NoYes085
70G.H5.10 G.S5.03 12.21435.7775NoNo068
71G.H5.10 G.S6.02 11.97998.24917NoYes067
72G.H5.15 I2x51 73.11513.47667NoNo077
73G.H5.15 G.H5.19 72.87513.5425NoNo078
74G.H5.19 I2x53 72.6359.7875NoYes087
753x50 G.H5.23 61.14294.495YesNo094
763x53 G.H5.23 61.38722.9975NoNo084
773x53 I2x53 61.63178.48167NoYes087
78b.l17x5 b.l17x6 13.27343.19083NoYes169
79b.l17x5 b.l19x2 13.19923.92583NoYes169
80b.l17x3 b.l19x2 12.45444.935YesYes199
81g.ctx3 g.ctx5 17.01933.16417YesYes2299
82b.lhb1x11 g.ctx5 15.64763.8875NoYes049
83b.b25x7 b.lhb1x11 15.30835.53333NoNo074
84b.b25x7 b.b28x6 13.602914.2383NoYes079
85b.b12x5 b.b13x4 13.87183.80583NoNo064
86b.b12x7 b.b13x4 13.7092.77167NoNo094
87b.b13x5 b.b13x7 11.91576.59417NoYes047
88b.b12x5 b.b13x5 11.78415.40417NoNo064
89b.b12x7 b.l12x3 13.21998.43083NoNo095
90b.b21x7 b.b23x2 11.15655.95917YesYes056
913x50 7x53 57.32687.54417YesYes899
922x46 7x53 55.00493.22167YesYes899
932x46 7x49 49.61833.54833YesNo899
947x45 7x49 49.56479.99083NoNo099
956x48 7x45 48.8166.30917YesNo089
963x36 6x48 32.92324.595YesYes268
973x36 Lig 23.33194.68667YesYes260
98b.b13x2 b.l12x3 13.05672.4775NoNo045
99H.hdhe.01 b.b13x2 12.88940.1875YesNo004
100H.hdhe.01 H.hdhe.03 11.81520.195YesNo000
101H.HD.07 H.hdhe.03 11.50840.203333YesNo000
102G.H3.15 G.H3.18 52.19546.85583NoYes089
103G.H3.09 G.S5.02 61.03685.495YesNo196
104G.HG.15 G.s4h3.04 19.0575.95417YesYes078
105G.hgh4.01 G.s4h3.04 37.26693.41667YesYes968
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT7.8052YesYes5522
2x64NT10.332YesYes3512
E1NT7.08252YesYes4522
E2NT16.11082YesYes5512
2x65NT4.849172YesYes4512
7x31NT6.19752NoYes2522
2x572x618.1252YesYes6611
2x573x323.603332YesNo6511
2x573x363.216672YesYes6611
2x577x384.621672YesNo6511
2x577x425.075832YesNo6612
2x57Lig9.808332YesYes6010
2x603x285.22750NoNo4512
2x60Lig4.24250NoYes4010
2x612x6510.55922YesYes6411
2x617x393.316672YesNo6512
2x61Lig3.463332YesYes6010
2x64E14.9352YesYes3412
2x64Lig12.45922YesYes3010
3x25E14.190832NoYes9422
3x22E212.71752NoYes3521
3x253x294.35752NoNo9421
3x25E210.55922NoYes9521
3x26E24.90252NoYes5521
3x29Lig6.468332NoYes4010
3x32Lig4.673332NoYes5010
3x334x573.371672YesNo4712
3x335x435.355832YesYes4511
3x33Lig10.08332YesYes4010
3x366x484.5952YesYes6812
3x367x417.216672YesNo6712
3x36Lig4.686672YesYes6010
3x375x437.276670NoYes6521
4x605x3910.66250NoYes5721
E2E250.55252YesYes5511
5x36E216.91172NoYes4521
5x38E27.585832NoYes4521
5x37E28.456672NoYes4521
5x40E26.81250NoYes5521
6x58E211.0650NoYes3521
7x31E26.44252NoYes2521
E2E37.879172YesYes5112
7x34E212.6652YesYes4511
E2Lig26.17922YesYes5010
5x39E213.87922YesYes7511
5x365x384.511672NoNo4422
5x395x434.418332YesYes7511
5x435x4710.46922YesNo5712
5x43Lig14.42832YesYes5010
6x486x513.298332YesNo8622
6x487x414.681672YesNo8722
6x517x343.246670NoYes6421
6x547x346.508330NoYes4421
7x34Lig4.806672YesYes4010
7x38Lig5.181672NoYes5010
2x617x383.52252YesNo6511
2x642x657.350832YesYes3411
3x29E26.47252NoYes4511
4x59E25.790NoYes5521
5x39Lig3.855832YesYes7010
2x65Lig3.970832YesYes4010
3x353x363.066670NoYes7621
3x303x332.730NoYes6421
1x352x612.649170NoYes5621
2x563x322.603330NoNo4521
4x63E22.029170NoYes4521
2x657x351.4652YesNo4412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
93.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
92.86Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
86.67Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
85.71Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
85.71Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
85.71Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
80.00Single5XR8AM8415XR8-CB1-AM841
80.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
80.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
78.57Single7V3ZCP559407V3Z-CB1-CP55940
76.47Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
76.47Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
73.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
72.22Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
71.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
71.43Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
70.59Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
70.59Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
68.75Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
68.75Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
66.67Single5ZTYAM102575ZTY-CB2-AM10257
66.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
66.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
64.71Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
64.71Single6KQICP559406KQI-CB1-CP55940-Org27569
62.50Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
62.50Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
61.11Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
60.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
58.82Single5XRAAM115425XRA-CB1-AM11542
58.82Single7FEECP559407FEE-CB1-CP55940-ZCZ011
58.82Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
55.56Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
55.56Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
52.63Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
50.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
50.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
48.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
47.62Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
47.62Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
47.37Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
47.37Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
47.37Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
47.06Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
47.06Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
47.06Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
47.06Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
46.67Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
45.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
45.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
44.44Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
44.44Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
44.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
44.44Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
44.44Single8JXSPF-61428JXS-D1-PF-6142
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
43.48Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
42.86Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
42.86Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
42.86Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
42.86Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
42.11Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
42.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
42.11Single8E0GBU728E0G-μ-BU72
42.11Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
42.11Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
41.67Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
41.18Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
41.18Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.18Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
41.18Single8K5CAcipimox8K5C-HCA2-Acipimox
41.18Consensushca_onOrthosteric Ligandhca2_on
40.91Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
40.91Consensuslpl_onOrthosteric Ligands1p_on lpa_on
40.91Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
40.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
40.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
40.00Single7YITNalfurafine7YIT-κ-Nalfurafine
40.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
40.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
40.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
40.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
40.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
40.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
40.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
39.13Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
39.13Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
39.13Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
39.13Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
38.89Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
38.89Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
38.89Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.89Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
38.89Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
38.89Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
38.89Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.89Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.89Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.89Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
38.89Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.89Consensushca_on_gpOrthosteric Ligandhca2_on_gp
38.89Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
38.46Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
38.46Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
38.46Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
38.10Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.10Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
38.10Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
38.10Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
38.10Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
38.10Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
38.10Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
37.50Single6W25SHU91196W25-MC4-SHU9119-Ca
37.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
37.50Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
37.50Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
37.50Single8K5BNiacin8K5B-HCA2-Niacin
37.50Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
37.50Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
37.50Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
37.50Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
37.50Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
37.04Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
37.04Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
37.04Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
37.04Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
37.04Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
36.84Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.84Single5C1MBU725C1M-μ-BU72
36.84Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.84Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
36.84Single7C4SS1P7C4S-S1P3-S1P
36.84Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
36.84Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
36.84Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
36.84Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
36.84Single8TF5Oleic acid8TF5-GPR6-Oleic acid
36.84Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
36.84Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.84Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
36.84Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
36.36Single4UG2CGS216804UG2-A2A-CGS21680
36.36Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
36.36Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
36.36Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
36.36Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
36.36Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
36.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
36.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
36.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
36.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
35.48Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
35.29Single6AKXA4R6AKX-CCR5-A4R
35.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.29Single6B73MP11046B73-κ-MP1104
35.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
35.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
35.29Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
35.29Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.29Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
35.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
35.29Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
35.29Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.29Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
35.29Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
35.29Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
35.00Single4DJHJDTic4DJH-κ-JDTic
35.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
35.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
35.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
35.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
35.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
35.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
35.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
35.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
35.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
35.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
35.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
35.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
35.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
35.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
35.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
35.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
35.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
35.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
35.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
35.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
34.78Single4XT1Fractalkine4XT1-US28-Fractalkine
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7QA8Peptide7QA8-STE2-Peptide
34.78Single7QA8Peptide7QA8-STE2-Peptide
34.78Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
34.78Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
34.78Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
34.78Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
34.78Single8KIGSHU91198KIG-MC3-SHU9119-Ca
34.78Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
34.78Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single8ZRTET-18ZRT-ETB-ET-1
34.62Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
34.62Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
33.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
33.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
33.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
33.33Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
33.33Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8XYIVUF106618XYI-CXCR3-VUF10661
33.33Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
33.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
33.33Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
33.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
33.33Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
33.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
33.33Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
33.33Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
33.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
33.33Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.35Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
32.26Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
32.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.14Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
32.14Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
32.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
32.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
32.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.00Consensusangiotensin_onOrthosteric Ligandat1_on
32.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
32.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
31.82Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
31.82Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.82Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.82Single5X93K-87945X93-ETB-K-8794
31.82Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
31.82Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
31.82Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
31.82Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
31.82Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
31.82Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
31.82Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
31.82Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
31.82Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
31.82Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
31.82Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
31.82Consensusendothelin_offOrthosteric Ligandetb_off
31.82Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
31.82Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
31.82Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
31.82Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.82Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
31.82Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
31.82Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single2Y04Salbutamol2Y04-β1-Salbutamol
31.58Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.58Single4YAYZD-71554YAY-AT1-ZD-7155
31.58Single6DRXLisuride6DRX-5-HT2B-Lisuride
31.58Single6IIVDaltroban6IIV-TP-Daltroban
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
31.58Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
31.58Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
31.58Single7UL4Alvimopan7UL4-μ-Alvimopan
31.58Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
31.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
31.58Single7YXAONO-54306087YXA-S1P5-ONO-5430608
31.58Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Single8JXRLSD8JXR-D1-LSD
31.58Single8K5DGSK2560738K5D-HCA2-GSK256073
31.58Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
31.58Single8T1WCVN4248T1W-GPR6-CVN424
31.58Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
31.58Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.58Single9CHXS-Carazolol9CHX-β2-S-Carazolol
31.58Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
31.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
31.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Consensusblt_onOrthosteric Ligandblt1_on
31.58Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
31.58Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
31.58Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
31.58Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
31.58Consensusleukotriene_onOrthosteric Ligandblt_on
31.58Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
31.25Single3OE6IT1t3OE6-CXCR4-IT1t
31.25Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
31.25Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
31.25Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
31.25Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
31.25Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
31.25Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
31.25Consensus5ht2_onOrthosteric Ligand5ht2b_on
31.25Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single6IGLIRL16206IGL-ETB-IRL1620
31.03Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
31.03Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
31.03Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
31.03Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
31.03Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
31.03Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
30.77Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.77Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
30.77Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
30.77Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.77Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
30.77Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
30.77Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.77Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.77Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.77Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
30.77Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
30.43Single3NY9ICI118-5513NY9-β2-ICI118-551
30.43Single5EE7MK08935EE7-Glucagon-MK0893
30.43Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.43Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.43Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
30.43Single7SK9CCX6627SK9-ACKR3-CCX662
30.43Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
30.43Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.43Single8QJ2pN1628QJ2-MC4-pN162-Gs
30.43Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
30.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
30.00Single5TVNLSD5TVN-5-HT2B-LSD
30.00Single5WQCEMPA5WQC-OX2-EMPA
30.00Single5XPRBosentan5XPR-ETB-Bosentan
30.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
30.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single6TP6Filorexant6TP6-OX1-Filorexant
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
30.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
30.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
30.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
30.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
30.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
30.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8S4DCMF-0198S4D-Apelin-CMF-019
30.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
30.00Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
30.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
30.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
30.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
30.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
30.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensustrace-amine_onOrthosteric Ligandta1_on
29.63Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
29.63Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
29.63Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
29.63Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.63Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
29.63Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.63Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.63Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.41Single3OE9IT1t3OE9-CXCR4-IT1t
29.41Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
29.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
29.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
29.41Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
29.41Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
29.41Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.41Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
29.41Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
29.41Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
29.41Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
29.41Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
29.17Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
29.17Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
29.17Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
29.17Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
29.17Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
29.17Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.17Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
29.17Single8WDTphotoNECA8WDT-A2A-photoNECA
29.17Single8WKYPG-9348WKY-MC4-PG-934
29.17Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
29.17Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
29.17Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
29.03Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
29.03Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
28.57Single2YDVNECA2YDV-A2A-NECA
28.57Single3P0GBI1671073P0G-β2-BI167107
28.57Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
28.57Single4UHRCGS216804UHR-A2A-CGS21680
28.57Single4XT3Fractalkine4XT3-US28-Fractalkine
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5D5AS-Carazolol5D5A-β2-S-Carazolol
28.57Single5D5BS-Carazolol5D5B-β2-S-Carazolol
28.57Single5G53NECA5G53-A2A-NECA-Gs
28.57Single6FJ3PTH6FJ3-PTH1-PTH
28.57Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
28.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
28.57Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.57Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
28.57Single6TQ7SB-3348676TQ7-OX1-SB-334867
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
28.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
28.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
28.57Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
28.57Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
28.57Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.57Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
28.57Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
28.57Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
28.57Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
28.57Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
28.57Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
28.57Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
28.57Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
28.57Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
28.57Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
28.57Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
28.57Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
28.57Consensusa2_onOrthosteric Liganda2b_on
28.57Consensusa2_on_gpOrthosteric Liganda2b_on_gp
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.57Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
28.57Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.57Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
28.57Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.57Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensuslpa_onOrthosteric Ligandlpa1_on
28.57Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
28.57Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
28.57Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.57Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
28.57Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
28.21Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.12Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
28.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
28.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
27.78Single3ODUIT1t3ODU-CXCR4-IT1t
27.78Single5WS3EMPA5WS3-OX2-EMPA
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
27.78Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
27.78Single6TODEMPA6TOD-OX1-EMPA-Na
27.78Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
27.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
27.78Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
27.78Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
27.78Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
27.78Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
27.78Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
27.78Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
27.78Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
27.78Single8Y0HVUF114188Y0H-CXCR3-VUF11418
27.78Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
27.78Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
27.78Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
27.78Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
27.59Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
27.59Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
27.59Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
27.59Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.27Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.27Single3D4STimolol3D4S-β2-Timolol
27.27Single4LDEBI1671074LDE-β2-BI167107
27.27Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
27.27Single4PY02MeSATP4PY0-P2Y12-2MeSATP
27.27Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.27Single6A93Risperidone6A93-5-HT2A-Risperidone
27.27Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
27.27Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
27.27Single6IIURamatroban6IIU-TP-Ramatroban
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.27Single7DFPSpiperone7DFP-D2-Spiperone
27.27Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
27.27Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
27.27Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
27.27Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
27.27Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
27.27Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
27.27Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
27.27Single8JJ8Formoterol8JJ8-β2-Formoterol
27.27Single8JJLOlodaterol8JJL-β2-Olodaterol
27.27Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
27.27Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
27.27Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
27.27Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.27Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.27Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.92Single6PT2KGCHM076PT2-δ-KGCHM07
26.92Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
26.92Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
26.92Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.92Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
26.92Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
26.92Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
26.92Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.92Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
26.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
26.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
26.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
26.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
26.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
26.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
26.32Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
26.32Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6PS0S-Carazolol6PS0-β2-S-Carazolol
26.32Single6PS4ICI118-5516PS4-β2-ICI118-551
26.32Single6PS5S-Propranolol6PS5-β2-S-Propranolol
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.32Single6TPNHTL66416TPN-OX2-HTL6641
26.32Single6VI4JDTic6VI4-κ-JDTic
26.32Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.32Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
26.32Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.32Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
26.32Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
26.32Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
26.32Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
26.32Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7UL3Famotidine7UL3-H2-Famotidine
26.32Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.32Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
26.32Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
26.32Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
26.32Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
26.32Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
26.32Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
26.32Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
26.32Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.32Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
26.32Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
26.32Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
26.32Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
26.32Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
26.32Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
26.32Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
26.32Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
26.32Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
26.32Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
26.32Consensusalpha1_onOrthosteric Ligandalpha1a_on
26.32Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
26.32Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
26.32Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
26.32Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.32Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
26.32Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
26.32Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
26.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single6K1QIRL25006K1Q-ETB-IRL2500
26.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
26.09Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
26.09Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
26.09Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
26.09Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.09Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.09Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
26.09Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
26.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
26.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.09Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
26.09Single8XVJMacitentan8XVJ-ETA-Macitentan
26.09Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
26.09Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.09Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.09Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
26.09Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
26.09Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.93Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.93Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.93Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
25.93Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
25.93Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.93Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.93Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.81Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.81Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.81Consensusbombesin_onOrthosteric Ligandbb2_on
25.81Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
25.81Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.81Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single3NY8ICI118-5513NY8-β2-ICI118-551
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
25.00Single4QKX35V4QKX-β2-35V
25.00Single5DHGC-355DHG-NOP-C-35
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Single6PS1Timolol6PS1-β2-Timolol
25.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
25.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
25.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
25.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
25.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
25.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
25.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
25.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
25.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
25.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
25.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
25.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
25.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
25.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
25.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
25.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
25.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
25.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Consensusa3_onOrthosteric Liganda3a_on
25.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
25.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
25.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
25.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
25.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
25.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
25.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
24.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.24Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.24Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
24.24Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
24.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
24.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
24.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
24.14Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
24.14Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
24.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
24.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
24.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
24.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
24.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
24.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
24.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
24.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
24.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
24.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
24.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
24.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
23.81Single2RH1S-Carazolol2RH1-β2-S-Carazolol
23.81Single5JQHS-Carazolol5JQH-β2-S-Carazolol
23.81Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
23.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.81Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
23.81Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.81Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.81Single6GPXMK08126GPX-CCR2-MK0812
23.81Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
23.81Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.81Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
23.81Single6PS6Timolol6PS6-β2-Timolol
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
23.81Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
23.81Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.81Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
23.81Single7W41PD1762527W41-BB2-PD176252
23.81Single7WC6LSD7WC6-5-HT2A-LSD
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.81Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
23.81Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
23.81Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.81Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.81Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
23.81Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.81Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
23.81Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
23.81Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.81Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.81Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
23.81Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.81Consensusa3_on_gpOrthosteric Liganda3a_on_gp
23.81Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
23.81Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
23.81Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
23.81Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.81Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
23.81Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
23.81Consensusamine_offonOrthosteric Ligandamine_off amine_on
23.81Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
23.81Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
23.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.81Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
23.81Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
23.81Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
23.81Consensusblt_offOrthosteric Ligandblt1_off
23.81Consensusbombesin_offOrthosteric Ligandbb2_off
23.81Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
23.81Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
23.81Consensusdp_offOrthosteric Liganddp2_off
23.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.81Consensusep_offOrthosteric Ligandep4_off
23.81Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
23.81Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
23.53Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
23.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.53Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.53Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.53Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.53Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
23.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
23.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
23.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
23.33Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
23.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
23.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
23.08Single3QAKUK-4320973QAK-A2A-UK-432097
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.08Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
23.08Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
23.08Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.08Single7XNACYN1548067XNA-SST2-CYN154806
23.08Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.08Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
23.08Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.08Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.08Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
23.08Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
23.08Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.86Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
22.73Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single4U15Tiotropium4U15-M3-Tiotropium
22.73Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
22.73Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.73Single6J21Aprepitant6J21-NK1-Aprepitant
22.73Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.73Single6OL9Tiotropium6OL9-M5-Tiotropium
22.73Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.73Single6WGTLSD6WGT-5-HT2A-LSD
22.73Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
22.73Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.73Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.73Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.73Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
22.73Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
22.73Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
22.73Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
22.73Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
22.73Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
22.73Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.73Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
22.73Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.73Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.73Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8XVLZibotentan8XVL-ETA-Zibotentan
22.73Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.73Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
22.73Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
22.73Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
22.73Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
22.73Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
22.73Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
22.73Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
22.73Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
22.73Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
22.73Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.73Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
22.73Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.73Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
22.73Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.73Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.73Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.73Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
22.58Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
22.58Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.58Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.58Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
22.58Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbradykinin_onOrthosteric Ligandbk2_on
22.58Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
22.58Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
22.22Single5WF5UK-4320975WF5-A2A-UK-432097
22.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7SRQLSD7SRQ-5-HT2B-LSD
22.22Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
22.22Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.22Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
22.22Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
22.22Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
22.22Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
22.22Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
22.22Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.22Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.22Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
22.22Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
22.22Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.22Single9B9Y7DY9B9Y-CB1-7DY
22.22Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.22Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.22Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
22.22Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
22.22Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
21.88Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.74Single4AMIBucindolol4AMI-β1-Bucindolol
21.74Single5CXVTiotropium5CXV-M1-Tiotropium
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
21.74Single5X33BIIL2605X33-BLT1-BIIL260
21.74Single6CM4Risperidone6CM4-D2-Risperidone
21.74Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
21.74Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.74Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
21.74Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
21.74Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
21.74Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.74Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
21.74Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.74Single8JWY2-1188JWY-A2A-2-118
21.74Single8JWZAB9288JWZ-A2A-AB928-Na
21.74Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
21.74Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.74Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.74Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
21.74Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
21.74Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.74Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.74Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.74Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
21.74Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
21.74Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
21.74Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.74Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.74Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
21.74Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.74Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.74Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
21.43Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.43Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.43Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
21.43Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
21.43Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.43Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.43Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusvasop-oxy_onOrthosteric Ligandv2_on
21.43Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.21Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.21Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.05Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.05Single3PWHZM-2413853PWH-A2A-ZM-241385
21.05Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single5U09Taranabant5U09-CB1-Taranabant
21.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.05Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
21.05Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
21.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.05Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.05Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.05Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
21.05Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
21.05Single8IWESpermidine8IWE-TA9-Spermidine
21.05Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
21.05Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
21.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
21.05Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
21.05Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
21.05Single9BA0A1AKN9BA0-CB1-A1AKN
21.05Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
21.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.05Consensusalpha2_offOrthosteric Ligandalpha2c_off
21.05Consensusangiotensin_offOrthosteric Ligandat1_off
21.05Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.05Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.05Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.05Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
21.05Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
21.05Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.83Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.83Single6H7LDobutamine6H7L-β1-Dobutamine
20.83Single6IBLArformoterol6IBL-β1-Arformoterol
20.83Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.83Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
20.83Single7EZCUKA7EZC-A2A-UKA
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.83Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
20.83Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.83Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.83Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.83Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.83Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.83Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.83Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensuschemerin_onOrthosteric Ligandcml1_on
20.83Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.69Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.69Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.69Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.69Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.69Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.59Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
20.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
20.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
20.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
20.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
20.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
20.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
20.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
19.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
19.23Single7F8XNN90567F8X-CCKA-NN9056
19.23Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8IEIA1LYA8IEI-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
19.23Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
19.23Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.23Consensussomatostatin_offOrthosteric Ligandsst2_off
19.05Single2Y01Dobutamine2Y01-β1-Dobutamine
19.05Single2Y02Carmoterol2Y02-β1-Carmoterol
19.05Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.05Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.05Single4DAJTiotropium4DAJ-M3-Tiotropium
19.05Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
19.05Single4MQSIperoxo4MQS-M2-Iperoxo
19.05Single4U14Tiotropium4U14-M3-Tiotropium
19.05Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
19.05Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
19.05Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.05Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.05Single5UENDU1725UEN-A1-DU172
19.05Single5UIGCmpd-15UIG-A2A-Cmpd-1
19.05Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
19.05Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
19.05Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
19.05Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.05Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
19.05Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
19.05Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.05Single7BU7BI1671077BU7-β1-BI167107
19.05Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
19.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
19.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
19.05Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
19.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.05Single8CU6LJ-45178CU6-A2A-LJ-4517
19.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
19.05Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
19.05Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
19.05Single8JJOAlprenolol8JJO-β2-Alprenolol
19.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.05Single8RLNLUF58348RLN-A2A-LUF5834
19.05Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
19.05Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
19.05Single8X63Mepyramine8X63-H1-Mepyramine
19.05Single8X64Desloratadine8X64-H1-Desloratadine
19.05Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
19.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
19.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
19.05Single9B9ZA1AKO9B9Z-CB1-A1AKO
19.05Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
19.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
19.05Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Consensusalpha2_onOrthosteric Ligandalpha2b_on
19.05Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
19.05Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.05Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
19.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.05Consensushistamine_offOrthosteric Ligandh1_off
19.05Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.05Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
19.05Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
19.05Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
18.75Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
18.75Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.75Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.52Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.52Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.52Single8IEBA1LYA8IEB-GPR156-A1LYA
18.52Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
18.18Single2Y00Dobutamine2Y00-β1-Dobutamine
18.18Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.18Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
18.18Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.18Single5N2SPSB365N2S-A1-PSB36
18.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.18Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.18Single6HLPNetupitant6HLP-NK1-Netupitant
18.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
18.18Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.18Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.18Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
18.18Single8QOTNanobody-E8QOT-μ-Nanobody-E
18.18Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
18.18Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.18Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.18Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
18.18Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
18.18Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
18.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.65Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.65Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
17.65Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
17.65Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.65Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.39Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.39Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
17.39Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.39Single5TZRMK86665TZR-FFA1-MK8666
17.39Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.39Single6E59L-7607356E59-NK1-L-760735
17.39Single6J20Aprepitant6J20-NK1-Aprepitant
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.39Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.39Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
17.39Single8EA0Iperoxo8EA0-M3-Iperoxo
17.39Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
17.39Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.39Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.39Single9BJKNAM9BJK-μ-Naloxone-NAM
17.39Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.39Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.39Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.39Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Consensusneurotensin_onOrthosteric Ligandnts1_on
17.39Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.24Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
17.24Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.24Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
17.24Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4XEENeurotensin4XEE-NTS1-Neurotensin
16.67Single4XESNeurotensin4XES-NTS1-Neurotensin
16.67Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
16.67Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
16.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
16.67Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
16.67Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
16.67Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.67Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
16.67Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
16.67Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.13Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
16.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
15.79Single3PBLEticlopride3PBL-D3-Eticlopride
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6LI0C176LI0-GPR52-C17
15.79Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.79Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
15.79Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
15.79Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
15.79Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.79Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
15.79Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
15.79Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
15.79Consensusgq_nucleotideOrthosteric Ligandgq_p2y
15.79Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.62Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.38Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
15.38Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.15Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
15.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
15.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
15.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
15.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
15.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.81Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
14.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.81Single8XWNCXCL88XWN-CXCR2-CXCL8
14.81Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single3REYXAC3REY-A2A-XAC
14.29Single3RZECidoxepin3RZE-H1-Cidoxepin
14.29Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
14.29Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
14.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
14.29Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
14.29Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusgrh_offOrthosteric Ligandgnrh1_off
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
14.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensussensory_offOrthosteric Ligandopsins_off
14.29Consensusvasop-oxy_offOrthosteric Ligandot_off
13.64Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.64Single3EMLZM-2413853EML-A2A-ZM-241385
13.64Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.64Single4QIMANTA XV4QIM-SMO-ANTA XV
13.64Single5DSGTiotropium5DSG-M4-Tiotropium
13.64Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.64Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.64Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.64Single5T04Neurotensin5T04-NTS1-Neurotensin
13.64Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.64Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.64Single6S0LZM-2413856S0L-A2A-ZM-241385
13.64Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.64Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.64Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7PYRPSB-21157PYR-A2A-PSB-2115
13.64Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
13.64Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.64Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.64Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
13.64Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
13.64Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.64Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.51Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.33Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
13.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.33Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.04Single4JKVTaladegib4JKV-SMO-Taladegib
13.04Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
13.04Single5CGCHTL142425CGC-mGlu5-HTL14242
13.04Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.04Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.04Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.04Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.04Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.04Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.04Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.04Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.04Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.04Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.04Single7SINNPS-21437SIN-CaS-NPS-2143
13.04Single7SINNPS-21437SIN-CaS-NPS-2143
13.04Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.04Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.04Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.04Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.04Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.90Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7PX4PSB-21137PX4-A2A-PSB-2113
12.50Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.50Consensustachykinin_offOrthosteric Ligandnk1_off
12.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.90Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.76Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.76Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.76Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.54Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.54Single5CGDHTL142425CGD-mGlu5-HTL14242
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.54Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
11.54Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
11.54Single8XVUCXCL28XVU-CXCR2-CXCL2
11.54Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.11Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
11.11Consensussensory_onOrthosteric Ligandopsins_on
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.53Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.53Single4XNWMRS25004XNW-P2Y1-MRS2500
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.53Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.53Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.53Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.53Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.53Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.53Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.34Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
9.52Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
9.52Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.52Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.52Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.52Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.52Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.52Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.52Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
9.52Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.38Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.09Single5UVIZM-2413855UVI-A2A-ZM-241385
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.09Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
8.82Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.70Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.33Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.00Single7P2L4YI7P2L-mGlu5-4YI
8.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.69Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Single8XWACXCL18XWA-CXCR2-CXCL1
7.69Single8XWMCXCL68XWM-CXCR2-CXCL6
7.69Single8XWSCXCL58XWS-CXCR2-CXCL5
7.69Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.41Single8XWFCXCL38XWF-CXCR2-CXCL3
7.41Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.14Single6KNMJN241-96KNM-Apelin-JN241-9
7.14Single8XQJJN2418XQJ-Apelin-JN241
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.88Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.56Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.56Single8HS2Fab0468HS2-GPR20-Fab046
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.26Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.26Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.26Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.00Single3UZAGTPL92363UZA-A2A-GTPL9236
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
4.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
4.76Single7UL2SR486927UL2-NTS1-SR48692-Na
4.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Consensusneurotensin_offOrthosteric Ligandnts1_off
4.76Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.55Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.55Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.55Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.35Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.35Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.35Single7VV6C48/807VV6-MRGPRX2-C48/80
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8IYXYL-3658IYX-GPR34-YL-365
4.17Single6FFHFenobam6FFH-mGlu5-Fenobam
4.17Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
3.85Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
cb2_on_gp 8GUR-CB2-CP55,940-Gi1/β1/γ2
8GUS-CB2-HU-308-Gi1/β1/γ2
8GUT-CB2-LEI-102-Gi1/β1/γ2
6KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6PT0-CB2-WIN 55212-2-Gi1/β1/γ2
8GUQ-CB2-Olorinab-Gi1/β1/γ2
cb1_on_gp 6KPG-CB1-AM841-Gi1/β1/γ2
8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
Net Summary
Imin 3.14583
Number of Linked Nodes 1015
Number of Links 1216
Number of Hubs 193
Number of Links mediated by Hubs 741
Number of Communities 25
Number of Nodes involved in Communities 252
Number of Links involved in Communities 374
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 2767050
Length Of Smallest Path 3
Average Path Length 38.3192
Length of Longest Path 71
Minimum Path Strength 0.403472
Average Path Strength 5.68765
Maximum Path Strength 21.9579
Minimum Path Correlation 0.7025
Average Path Correlation 0.979101
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.6129
Average % Of Corr. Nodes 29.5866
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.321
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
cannabinoid_off_on_gpcannabinoid_on_gpcannabinoid_off
This network is also present in following consensuses:
IdComponents
lipid_on_gpcannabinoid_on_gp
ffa_on_gp
lpl_on_gp
prostanoid_on_gp
leukotriene_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cannabinoid_on_gp.zip



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