Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x35 3.61109405
21x39 5.71969407
31x43 4407
41x50 5.06328409
51x60 4.02094606
62x42 4.4876608
72x50 5.809375129
82x57 4.11531407
9E1x50 7.59083628
10E1x52 6.25187506
113x37 2.88453408
123x49 6.936724139
133x50 7.02766409
143x51 5.556385208
15I2x51 3.25719407
16I2x57 4.658385137
174x50 4.428656199
18E2 13.89361822.71429
19E2x52 8.20391425
205x43 4.45344427
215x47 4.69766408
225x58 5.81578409
236x30 2.47406408
246x48 5.38781608
256x51 4.63363527
266x60 3.61328425
27E3 5.1634923.125
287x42 4.14437427
297x49 5.801414129
307x53 4.79859409
31b.1x4 1.74363508
32b.lhb1x6 4.79219473
33b.b1x3 4.47094467
34b.b1x6 8.02703469
35b.l1x3 7.99917669
36b.b2x1 8.40075518
37b.b2x5 6.15719607
38b.b3x3 4.31141408
39b.l3x2 5.40913569
40b.b4x2 4.66484408
41b.b4x3 4.088284157
42b.b4x6 8.79991769
43b.b5x2 6.04953407
44b.b5x3 6.32063669
45b.b5x7 5.87109407
46b.l5x1 3.97155158
47b.l5x5 6.23883819
48b.b6x5 4.66594406
49b.b7x1 5.06413504
50b.b7x4 3.227194158
51b.b8x3 3.92984406
52b.b8x4 5.2356156
53b.l8x9 2.51859403
54b.b9x3 4.82047406
55b.l9x3 7.31729619
56b.l9x6 5.88156618
57b.b10x5 4.29729609
58b.b11x4 5.17275519
59b.l11x2 7.75662519
60b.b12x5 3.91563456
61b.b12x6 7.73054718
62b.b13x7 8.11625557
63b.l13x3 6.7567759
64b.l13x6 5.38578419
65b.b14x3 4.73641455
66b.b15x1 8.25625459
67b.b15x2 7.08734446
68b.l15x1 4.27734417
69b.l15x2 5.13338559
70b.b16x4 11.5359456
71b.b16x5 4.86016405
72b.b16x6 7.65723758
73b.b16x7 8.695314169
74b.b17x4 5.971884165
75b.b17x7 8.21922448
76b.l17x3 8.085749
77b.l17x6 6.43677619
78b.b18x3 5.27922448
79b.l18x1 6.01295796
80b.l18x2 6.0625497
81b.b19x2 7.46275546
82b.b19x4 6.08141448
83b.l19x2 6.7295549
84b.b20x2 5.23328446
85b.b20x4 9.07323648
86b.b20x6 6.57906646
87b.b20x7 4.00297409
88b.l20x2 7.41625409
89b.b21x1 5.94719647
90b.b21x7 5.29357705
91b.l21x5 3.83525514
92b.l21x7 3.85313415
93b.b22x5 4.9185597
94b.l22x5 7.0945579
95b.b23x6 6.11446717
96b.l23x1 8.52609416
97b.b24x3 3.94422405
98b.b24x4 7.28363516
99b.b24x7 7.96359479
100b.l24x2 4.01109406
101b.l25x3 8.10962589
102b.l27x1 6.712344147
103b.l27x5 5.670944145
104b.b27x3 5.12906408
105b.l28x1 12.4976619
106b.l28x2 8.42922489
107b.b28x3 4.03125567
108b.b28x4 7.27422486
109b.b28x6 8.4395589
110g.h1x5 2.09047406
111g.l1x4 3.87078408
112g.h2x11 9.54547496
113g.ctx3 6.403509
114g.ctx6 4.22641476
115g.ctx16 5.03804768
116G.HN.11 1.43375402
117G.S1.05 5.50453419
118G.H1.04 4.41302637
119G.S2.04 5.586385227
120G.S2.06 2.99188508
121G.S2.08 2.94016405
122G.S3.03 4.74104607
123G.S3.04 6.82766407
124G.S3.07 3.618966229
125G.S3.08 4.36328419
126G.H2.04 5.04375519
127G.H2.06 5.8525619
128G.H2.07 5.97802619
129G.H2.08 4.01188418
130G.h2s4.01 5.3276619
131G.S4.04 6.33859419
132G.s4h3.01 4.880164187
133G.s4h3.03 5.499064177
134G.s4h3.04 5.63479638
135G.s4h3.05 8.68406439
136G.H3.01 7.728914179
137G.H3.06 5.20797407
138G.H3.09 6.27137509
139G.H3.12 4.33375517
140G.H3.15 4.29792618
141G.H3.17 5.50781405
142G.H3.18 6.00938419
143G.S5.05 3.88586839
144G.S5.06 5.28254188
145G.S5.07 4.06712539
146G.HG.07 6.69547439
147G.HG.08 2.12766406
148G.HG.15 5.37641436
149G.hgh4.02 4.60388538
150G.hgh4.05 7.30516436
151G.H4.10 5.42781637
152G.H4.12 4.430634185
153G.H4.15 5.04094409
154G.S6.02 6.169827108
155G.S6.05 7.385634185
156G.s6h5.01 5.03525539
157G.s6h5.02 3.10437407
158G.s6h5.05 3.60138539
159G.H5.03 4.99906638
160G.H5.20 3.28688508
161G.H5.23 5.919066134
162Lig 10.29152620
1638x57 3.44953400
164NT 7.00607720
165I3 2.669519104
166G.HN.09 0.444531400
167G.h1ha.04 2.92400
168H.HA.13 1.406500
169H.HA.16 2.51775500
170H.hahb.06 3.08625404
171H.HB.10 2.67719401
172H.hchd.01 2.48625508
173H.HD.07 3.81125404
174H.HE.02 2.30125407
175H.HE.04 5.054119
176H.HE.09 0.920625405
177H.hehf.04 2.649508
178H.HF.03 3.975944119
179H.HF.06 5.416874116
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x36 Lig 37.2617.84812NoYes270
23x36 6x48 37.51454.3575NoYes078
36x48 7x45 21.15937.95375YesNo089
47x45 7x49 21.43745.99125NoYes099
56x44 6x48 21.09078.45687NoYes098
65x54 6x44 22.90973.1225NoNo089
73x47 5x54 23.04815.91875NoNo098
83x47 5x58 24.43695.52938NoYes099
93x50 5x58 24.8545.78625YesYes099
103x50 G.H5.23 12.43497.01062YesYes094
113x43 7x49 24.48466.09437NoYes1299
123x43 7x53 27.73044.10375NoYes099
133x50 7x53 28.97316.0525YesYes099
143x50 G.H5.25 65.37379.26125YesNo098
15G.H5.20 G.H5.25 65.50613.2875YesNo088
16G.H5.17 G.H5.20 67.35692.90937NoYes058
17G.H5.13 G.H5.17 67.98074.16438NoNo075
18G.H5.13 G.S6.02 67.994110.4875NoYes1078
19G.H5.10 G.S6.02 70.64135.505NoYes078
20G.H5.10 G.S5.03 70.77243.35125NoNo078
21G.S5.03 G.S5.05 71.45893.8475NoYes089
22G.H5.07 G.S5.05 27.71842.9475NoYes089
23G.H5.07 G.S4.03 27.57812.85NoNo087
24G.H1.04 G.S5.05 48.13634.2875YesYes379
25G.H1.04 G.S5.07 48.33834.30438YesYes379
26G.S5.07 G.s5hg.01 97.93194.285YesNo399
27G.s4h3.02 G.s5hg.01 97.95384.78125NoNo399
28G.HG.07 G.s4h3.02 98.06573.63375YesNo399
29G.HG.07 G.s4h3.04 97.94986.045YesYes398
30G.HG.04 G.s4h3.04 48.99434.32375NoYes088
31G.HG.04 G.s4h3.01 49.00464.75625NoYes087
32G.S5.06 G.s4h3.01 48.82967.78312YesYes1887
33G.S5.04 G.S5.06 49.00393.37312NoYes088
34G.H3.09 G.S5.04 49.01483.8825YesNo098
35G.H3.09 G.S4.04 10010.7188YesYes099
36G.H3.08 G.S4.04 31.11513.35NoYes199
37G.H2.04 G.H3.08 31.07763.56563YesNo199
38G.H2.04 G.H2.07 26.11417YesYes199
39G.H2.02 G.H2.07 27.76915.55875NoYes189
40G.H2.02 b.l9x6 27.67615.48688NoYes188
41G.H2.06 b.l9x6 21.98194.17812YesYes198
42G.H2.06 b.l17x6 21.4768.815YesYes199
43b.l17x5 b.l17x6 21.47043.12813NoYes069
44b.l17x5 b.l19x2 21.37024.87687NoYes069
45b.l17x3 b.l19x2 11.93094.96125YesYes499
46b.b17x7 b.b20x6 14.957710.3831YesYes486
47b.b17x7 b.b21x1 14.14474.62937YesYes487
48G.S5.05 G.s6h5.01 48.22763.7275YesYes399
49G.S5.07 G.s6h5.01 49.30285.57438YesYes399
50G.HG.15 G.s4h3.04 49.80695.64187YesYes368
51G.HG.15 G.hgh4.02 49.60163.50125YesYes368
52G.H3.02 G.hgh4.02 49.85035.59875NoYes088
53G.H3.02 G.H4.15 49.89383.88875NoYes089
54G.H3.09 G.H4.15 50.55925.09062YesYes099
55G.H3.12 G.S4.04 49.42445.65312YesYes179
56G.H2.04 G.H3.12 31.08213.75813YesYes197
57b.b20x4 b.b20x6 12.46123.81YesYes486
58G.S1.07 G.S4.04 19.4465.6325NoYes199
59G.S1.05 G.S1.07 19.41454.32562YesNo199
60G.S1.05 G.h2s4.01 19.242610.6562YesYes199
61G.H2.10 G.h2s4.01 19.56243.40375NoYes179
62G.H2.10 b.b2x1 19.46344.62NoYes178
63b.b2x1 b.l28x1 19.48519.95062YesYes189
64b.l25x6 b.l28x1 71.769122.8025NoYes189
65b.l23x1 b.l25x6 71.384321.6631YesNo168
66b.l21x7 b.l23x1 71.01064.18YesYes156
67b.b23x6 b.l21x7 69.853.4425YesYes175
68b.b23x6 b.b24x6 67.16865.84812YesNo178
69b.b21x7 b.b24x6 67.04689.8275YesNo058
70G.H2.04 G.H2.08 36.11273.7575YesYes198
71G.H2.08 G.H3.17 54.02834.1125YesYes085
72G.H2.09 G.H3.17 53.16796.87937NoYes085
73G.H2.09 b.l28x1 53.0256.35063NoYes189
74G.H3.12 G.H3.15 18.31564.2325YesYes178
75G.H2.08 G.H3.15 18.04793.6275YesYes188
76b.b21x5 b.b21x7 57.52327.48375NoYes045
77b.b21x5 b.h2x1 57.33187.775NoNo045
78b.h2x1 b.h2x5 57.26452.85625NoNo055
79b.h2x5 b.l24x2 55.53464.515NoYes056
80b.l22x5 b.l24x2 54.76496.4525YesYes096
81b.l22x5 g.ctx6 52.83054.02125YesYes796
82g.ctx3 g.ctx6 52.27258.06063YesYes096
83g.ctx3 g.ctx4 37.45774.32688YesNo097
84b.l27x5 g.ctx4 37.06714.61312YesNo057
85b.l22x1 g.ctx3 14.66998.27812NoYes099
86b.l22x1 g.ctx5 11.32683.00125NoNo099
87b.l27x1 b.l27x5 27.90213.015YesYes1475
88b.b2x5 b.l27x1 27.512910.6144YesYes077
89b.b2x5 b.b3x2 26.336110.1788YesNo075
90b.b3x2 b.b4x6 26.13975.62313NoYes059
91b.b4x6 b.l1x3 22.06813.24YesYes699
92b.l1x3 b.l3x2 21.53252.9925YesYes699
93b.b4x2 b.l3x2 20.74126.05125YesYes089
94b.b4x2 b.b5x8 19.74933.55562YesNo085
95b.b5x7 b.b5x8 19.55083.39YesNo075
96b.b4x3 b.b5x7 14.16874.72625YesYes077
97b.b3x3 b.b4x3 13.00364.19062YesYes087
98b.b3x3 b.b6x5 12.00944.415YesYes086
99b.b2x4 b.b6x5 11.40934.01938NoYes066
100b.b10x4 b.b2x4 11.209115.2325NoNo066
101b.b10x2 b.b10x4 11.0094.18NoNo066
102b.b10x2 b.b14x3 10.80883.56687NoYes065
103G.S3.05 G.S4.03 23.90334.69125NoNo077
104G.S2.04 G.S3.05 23.30062.69438YesNo077
105G.S2.04 G.S3.07 22.75414.38312YesYes2279
106G.H1.01 G.S3.07 21.924.7525NoYes099
107G.H1.01 G.hfs2.02 21.66624.0675NoNo099
108G.hfs2.02 H.hdhe.04 21.39522.165NoNo097
109H.HE.01 H.hdhe.04 13.90712.445NoNo097
110H.HE.01 H.HF.06 13.78024.6125NoYes096
111H.HE.11 H.HF.03 11.96084.16875NoYes089
112H.HE.11 H.hehf.04 11.4532.70125NoYes088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x357x355.641250YesNo5521
2x563x325.671250NoNo7821
2x567x423.070630NoYes7721
2x577x425.9050YesYes7721
2x63E1x506.652NoYes5812
2x63Lig6.236252NoYes5010
E1x49E24.265620NoYes42.7142921
3x22E29.106252NoYes42.7142921
3x294x6512.83252NoNo5612
3x29Lig4.12NoYes5010
3x32Lig4.93752NoYes8010
3x334x574.65252NoNo6812
3x33Lig3.128132NoYes6010
3x366x484.35752NoYes7812
3x36Lig7.848122NoYes7010
4x61E2x525.305622NoYes7511
4x61Lig4.945632NoYes7010
4x64E27.931872NoYes42.7142921
4x65E2x527.81750NoYes6521
E2E255.66752YesYes2.714292.7142911
E2E2x516.506882YesNo2.71429411
E2Lig33.75312YesYes2.71429010
E2x51Lig4.97752NoYes4010
E2E2x529.57752YesYes2.71429511
E2x52Lig10.1152YesYes5010
5x36E27.5652NoYes52.7142921
5x39E23.713752NoYes72.7142921
5x35E27.7250NoYes42.7142921
5x395x433.698752NoYes7721
5x406x593.203122NoNo6612
6x517x373.088752YesNo7612
6x51Lig8.373752YesYes7010
6x55Lig8.241252NoYes7010
6x57E35.425632NoYes53.12521
6x58Lig11.27382NoYes4010
E3Lig9.62752YesYes3.125010
E3E33.574382YesYes3.1253.12511
7x34Lig11.22442NoYes4010
7x38Lig8.52752NoYes5010
7x42Lig5.421882YesYes7010
2x64Lig4.408130NoYes5010
2x60Lig9.180622NoYes7010
5x43Lig7.851872YesYes7010
E1x50E23.029382YesYes82.7142921
5x436x553.080632YesNo7711
6x517x384.596252YesNo7511
2x67E24.666872NoYes42.7142921
6x516x553.926882YesNo7711
E2NT19.7152YesYes2.71429011
NTNT7.381252YesYes0011
LigNT6.166252YesYes0001
7x24NT3.640NoYes0021
2x602x633.371252NoNo7511
E1Lig9.191250NoYes0010
6x62E24.5452NoYes12.7142921
5x436x513.18252YesYes7711
6x60E33.89752YesYes53.12521
7x31Lig13.1950NoYes3010
7x35Lig3.36752NoYes5010
5x29E23.001252NoYes02.7142921
E2E311.7752YesYes2.714293.12511
5x29E35.581252NoYes03.12521
5x366x603.2852NoYes5522
6x586x623.423752NoNo4112
7x28NT2.726250NoYes0021
6x587x302.692NoNo4012
6x547x342.493750NoNo5421
2x537x422.180NoYes7721
7x26E32.12252NoYes03.12521
5x40Lig2.065632NoYes6010
7x32NT2.03250NoYes3021
1x317x351.918750NoNo2521
5x28E21.87252NoYes02.7142921
6x63E30.89250NoYes03.12521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
71.43Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
68.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
66.67Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
65.52Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
65.38Consensusangiotensin_onOrthosteric Ligandat1_on
65.38Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
64.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
64.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
62.96Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
62.96Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
62.07Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
61.54Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
60.71Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
60.71Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
60.00Single6IGLIRL16206IGL-ETB-IRL1620
60.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
60.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
60.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
59.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
58.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
58.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.62Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.62Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
58.06Single5GLHEndothelin-15GLH-ETB-Endothelin-1
58.06Single6IGKEndothelin-36IGK-ETB-Endothelin-3
57.69Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
57.69Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
57.69Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
57.58Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
57.14Single6JODAngiotensin II6JOD-AT2-Angiotensin II
57.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
57.14Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
57.14Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
56.25Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
56.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
55.56Single3QAKUK-4320973QAK-A2A-UK-432097
55.56Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
55.56Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
55.56Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
55.56Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
55.17Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
55.17Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
54.55Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
54.17Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
54.17Consensuscck_onOrthosteric Ligandccka_on cckb_on
53.85Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
53.85Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
53.85Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
53.85Consensuslpl_offOrthosteric Ligands1p_off lpa_off
53.85Consensuslpl_onOrthosteric Ligands1p_on lpa_on
53.85Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.57Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
53.57Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
53.57Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
53.33Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
53.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
53.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
53.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
53.12Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
53.12Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
52.94Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
52.94Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
52.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
52.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
52.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
52.00Consensusdp_offOrthosteric Liganddp2_off
52.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
52.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
52.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
51.85Single4IARErgotamine4IAR-5-HT1B-Ergotamine
51.85Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
51.85Single7F8XNN90567F8X-CCKA-NN9056
51.85Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
51.85Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
51.85Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
51.85Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
51.85Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
51.85Consensussst_onOrthosteric Ligandsst2_on sst4_on
51.72Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
51.72Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
51.72Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
51.72Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
51.61Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
51.61Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
51.61Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
51.61Consensusendothelin_onOrthosteric Ligandetb_on eta_on
51.52Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
50.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
50.00Single7EZCUKA7EZC-A2A-UKA
50.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
50.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
50.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
50.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
50.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
50.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
50.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
50.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
50.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
50.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
50.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
50.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
50.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
50.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
50.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
50.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
50.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
50.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
50.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusorexin_onOrthosteric Ligandox2_on
50.00Consensussteroid_onOrthosteric Ligandbileacid_on
48.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
48.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
48.39Single4XT3Fractalkine4XT3-US28-Fractalkine
48.39Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
48.39Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
48.39Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
48.39Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
48.39Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
48.39Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
48.28Single3OE0CVX153OE0-CXCR4-CVX15
48.28Single5WF5UK-4320975WF5-A2A-UK-432097
48.28Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
48.28Single6PT2KGCHM076PT2-δ-KGCHM07
48.28Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
48.28Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
48.28Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
48.28Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
48.28Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
48.28Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.15Single4UG2CGS216804UG2-A2A-CGS21680
48.15Single5WF6UK-4320975WF6-A2A-UK-432097
48.15Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
48.15Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.15Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
48.15Single7XN9L-054,5227XN9-SST2-L-054,522
48.15Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
48.15Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
48.15Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
48.15Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
48.15Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.15Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
48.15Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
48.15Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
48.15Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
48.15Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
48.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
48.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
48.00Single8E0GBU728E0G-μ-BU72
48.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
48.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
48.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
47.06Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
47.06Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
46.88Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
46.88Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
46.88Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
46.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
46.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
46.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
46.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
46.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
46.67Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
46.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
46.43Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
46.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
46.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
46.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.43Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
46.43Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
46.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
46.43Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
46.43Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
46.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
46.15Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
46.15Single6MXTSalmeterol6MXT-β2-Salmeterol
46.15Single6OS2TRV0266OS2-AT1-TRV026
46.15Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
46.15Single7YITNalfurafine7YIT-κ-Nalfurafine
46.15Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
46.15Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
46.15Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
46.15Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single8JJLOlodaterol8JJL-β2-Olodaterol
46.15Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
46.15Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
46.15Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
46.15Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
45.83Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
45.83Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
45.83Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
45.83Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
45.83Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
45.83Single8K5DGSK2560738K5D-HCA2-GSK256073
45.83Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
45.83Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
45.83Consensusgi_hcarOrthosteric Ligandgi_hca
45.83Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
45.45Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
45.45Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
45.45Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
45.45Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.16Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
45.16Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.16Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.16Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
45.16Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.16Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.16Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
44.83Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
44.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
44.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
44.83Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
44.83Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
44.44Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
44.44Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
44.44Single6IBLArformoterol6IBL-β1-Arformoterol
44.44Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
44.44Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
44.44Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
44.44Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
44.44Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
44.44Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
44.44Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
44.44Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
44.44Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
44.44Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
44.00Single5C1MBU725C1M-μ-BU72
44.00Single5N2SPSB365N2S-A1-PSB36
44.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
44.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
44.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
44.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
44.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
44.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
44.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
44.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
44.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
44.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
44.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
43.75Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.33Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
43.33Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
43.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
43.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
43.33Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
43.33Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
43.33Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
43.33Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single3NY9PubChem 9131033NY9-β2-PubChem 913103
42.86Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
42.86Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
42.86Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
42.86Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
42.86Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
42.86Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
42.86Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
42.86Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.42Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.42Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
42.31Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
42.31Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
42.31Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
42.31Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
42.31Single6OS1TRV0266OS1-AT1-TRV026
42.31Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
42.31Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
42.31Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
42.31Single7TUYGSK682753A7TUY-GPR183-GSK682753A
42.31Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.31Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
42.31Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
42.31Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
42.31Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
42.31Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
42.31Consensusa2_onOrthosteric Liganda2a_on a2b_on
42.31Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.31Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
42.31Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
42.31Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
42.31Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
42.31Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.31Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
42.31Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
42.31Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
42.31Consensuslpa_offOrthosteric Ligandlpa1_off
42.31Consensuslpa_onOrthosteric Ligandlpa1_on
41.94Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
41.94Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
41.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
41.67Single7AROLUF58337ARO-A2A-LUF5833-Na
41.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
41.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
41.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
41.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
41.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
41.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
41.67Single8K5CAcipimox8K5C-HCA2-Acipimox
41.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
41.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
41.67Consensushcar_onOrthosteric Ligandhca_on
41.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
41.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
41.46Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
41.38Single4XT1Fractalkine4XT1-US28-Fractalkine
41.38Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
41.38Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.38Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
41.38Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
41.38Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
41.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
41.38Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.38Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
40.74Single4LDEBI1671074LDE-β2-BI167107
40.74Single4XEENeurotensin4XEE-NTS1-Neurotensin
40.74Single4XESNeurotensin4XES-NTS1-Neurotensin
40.74Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
40.74Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
40.74Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
40.74Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
40.74Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
40.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
40.74Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
40.74Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
40.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
40.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
40.74Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
40.74Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
40.74Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
40.74Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
40.74Single8JJ8Formoterol8JJ8-β2-Formoterol
40.74Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
40.74Single8JWZAB9288JWZ-A2A-AB928-Na
40.74Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
40.74Single8WU1KCA8WU1-CB1-KCA-Arrestin1
40.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
40.74Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
40.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
40.00Single6D27CAY104716D27-DP2-CAY10471
40.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
40.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
40.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.00Single6TOTLemborexant6TOT-OX1-Lemborexant
40.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
40.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
40.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
40.00Single7SK5CXCL127SK5-ACKR3-CXCL12
40.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
40.00Single7UL4Alvimopan7UL4-μ-Alvimopan
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
40.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
40.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
40.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
40.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
40.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
40.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
40.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
40.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
40.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
40.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
39.39Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
39.39Single7SK3CXCL127SK3-ACKR3-CXCL12
39.39Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
39.29Single4BUONeurotensin4BUO-NTS1-Neurotensin
39.29Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
39.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
39.29Single6H7LDobutamine6H7L-β1-Dobutamine
39.29Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
39.29Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
39.29Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
39.29Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
39.29Consensusendothelin_offOrthosteric Ligandetb_off
39.29Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
39.29Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.29Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
39.29Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.29Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.71Single6W25SHU91196W25-MC4-SHU9119-Ca
38.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
38.71Single7XNACYN1548067XNA-SST2-CYN154806
38.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
38.71Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
38.71Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
38.71Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
38.46Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
38.46Single5IUAQ274563485IUA-A2A-Q27456348-Na
38.46Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
38.46Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.46Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
38.46Single5WQCEMPA5WQC-OX2-EMPA
38.46Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
38.46Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
38.46Single6LPLZM2413856LPL-A2A-ZM241385-Na
38.46Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
38.46Single6S0QZM2413856S0Q-A2A-ZM241385
38.46Single6TP6Filorexant6TP6-OX1-Filorexant
38.46Single6WQAZM2413856WQA-A2A-ZM241385-Na
38.46Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
38.46Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
38.46Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
38.46Single7RM5ZM2413857RM5-A2A-ZM241385-Na
38.46Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
38.46Single7XKAEpinephrine7XKA-β2-Epinephrine
38.46Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
38.46Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single8FYNZM2413858FYN-A2A-ZM241385-Na
38.46Single8GNEKW-63568GNE-A2A-KW-6356-Na
38.46Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
38.46Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
38.46Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
38.46Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
38.46Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
38.46Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
38.46Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.46Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
38.46Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.24Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
37.93Single5ZTYAM102575ZTY-CB2-AM10257
37.93Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.93Single6PT3DPI-2876PT3-δ-DPI-287
37.93Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
37.93Single7SK9CCX6627SK9-ACKR3-CCX662
37.93Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
37.93Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
37.93Single8X5YAstemizole8X5Y-H1-Astemizole
37.93Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
37.93Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
37.93Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
37.84Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
37.50Single3PWHZM2413853PWH-A2A-ZM241385
37.50Single5WS3EMPA5WS3-OX2-EMPA
37.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.50Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.50Single6TODEMPA6TOD-OX1-EMPA-Na
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
37.50Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
37.50Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
37.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.04Single2YDVNECA2YDV-A2A-NECA
37.04Single3P0GBI1671073P0G-β2-BI167107
37.04Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
37.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
37.04Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
37.04Single4UHRCGS216804UHR-A2A-CGS21680
37.04Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
37.04Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
37.04Single5G53NECA5G53-A2A-NECA-Gs
37.04Single6H7JIsoprenaline6H7J-β1-Isoprenaline
37.04Single6J21Aprepitant6J21-NK1-Aprepitant
37.04Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
37.04Single6TQ7SB-3348676TQ7-OX1-SB-334867
37.04Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
37.04Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
37.04Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
37.04Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
37.04Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
37.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
37.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
37.04Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
37.04Single7PX4PSB-21137PX4-A2A-PSB-2113
37.04Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
37.04Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
37.04Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
37.04Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
37.04Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
37.04Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
37.04Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
37.04Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.04Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
37.04Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
37.04Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
37.04Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
37.04Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
37.04Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
37.04Consensus5ht5_offOrthosteric Ligand5ht5a_off
37.04Consensusadenosine_offOrthosteric Liganda1_off a2_off
37.04Consensuschemerin_onOrthosteric Ligandcml1_on
37.04Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
37.04Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.04Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
37.04Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
37.04Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
37.04Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
37.04Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
36.67Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
36.67Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
36.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
36.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.36Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
36.11Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
36.00Single3REYPubChem 56973REY-A2A-PubChem 5697
36.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
36.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
36.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
36.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
36.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
36.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
36.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
36.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
36.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
36.00Single6MH8ZM2413856MH8-A2A-ZM241385
36.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
36.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
36.00Single6TPGEMPA6TPG-OX2-EMPA
36.00Single6V9SGTPL114036V9S-OX1-GTPL11403
36.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
36.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
36.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
36.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
36.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
36.00Single8GGTEpinephrine8GGT-β2-Epinephrine
36.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
36.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
36.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
36.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
36.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
36.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
36.00Consensuss1p_offOrthosteric Ligands1p1_off
35.71Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.71Single4AMIBucindolol4AMI-β1-Bucindolol
35.71Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
35.71Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.71Single6A93Risperidone6A93-5-HT2A-Risperidone
35.71Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
35.71Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.71Single6YVRNTS8-136YVR-NTS1-NTS8-13
35.71Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
35.71Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.71Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.71Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.71Single7K15MKD0467K15-BLT1-MKD046-Na
35.71Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
35.71Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
35.71Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.71Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
35.71Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
35.71Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.71Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
35.71Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
35.71Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
35.71Consensusblt_offOrthosteric Ligandblt1_off
35.71Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.71Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
35.71Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
35.71Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
35.71Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
35.71Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
35.71Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.71Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
35.71Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
35.71Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.71Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
35.48Single6HLOAprepitant6HLO-NK1-Aprepitant
35.48Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
35.48Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
35.48Consensussst_offOrthosteric Ligandsst2_off
34.62Single2Y04Salbutamol2Y04-β1-Salbutamol
34.62Single3EMLZM2413853EML-A2A-ZM241385
34.62Single3NY8ICI 118-5513NY8-β2-ICI 118-551
34.62Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
34.62Single4EIYZM2413854EIY-A2A-ZM241385-Na
34.62Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
34.62Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
34.62Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
34.62Single4YAYZD-71554YAY-AT1-ZD-7155
34.62Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
34.62Single5IU8Q274563475IU8-A2A-Q27456347-Na
34.62Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
34.62Single5K2AZM2413855K2A-A2A-ZM241385-Na
34.62Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
34.62Single5OLGZM2413855OLG-A2A-ZM241385-Na
34.62Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
34.62Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
34.62Single5UENDU1725UEN-A1-DU172
34.62Single5VRAZM2413855VRA-A2A-ZM241385-Na
34.62Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
34.62Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
34.62Single6PS1Timolol6PS1-β2-Timolol
34.62Single6S0LZM2413856S0L-A2A-ZM241385
34.62Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
34.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
34.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
34.62Single7BU7BI1671077BU7-β1-BI167107
34.62Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
34.62Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
34.62Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
34.62Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
34.62Single7PYRPSB-21157PYR-A2A-PSB-2115
34.62Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
34.62Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
34.62Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
34.62Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
34.62Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
34.62Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
34.62Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
34.62Single8CU6LJ-45178CU6-A2A-LJ-4517
34.62Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
34.62Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
34.62Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
34.62Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
34.62Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
34.62Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8GGJEpinephrine8GGJ-β2-Epinephrine
34.62Single8GGNEpinephrine8GGN-β2-Epinephrine
34.62Single8GGOEpinephrine8GGO-β2-Epinephrine
34.62Single8GGUEpinephrine8GGU-β2-Epinephrine
34.62Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
34.62Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
34.62Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.62Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
34.62Consensusa2_offOrthosteric Liganda2a_off
34.62Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
34.62Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
34.62Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
34.62Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
34.62Consensusblt_onOrthosteric Ligandblt1_on
34.62Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
34.62Consensuscck_offOrthosteric Ligandccka_off
34.62Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
34.62Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
34.62Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
34.62Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
34.62Consensusleuko_onOrthosteric Ligandblt_on
34.48Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
34.48Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
34.48Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
34.48Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
34.48Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
34.48Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
34.48Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
34.48Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
34.48Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
34.48Single7UM4AS26747237UM4-5-HT5A-AS2674723
34.48Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
34.48Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
34.48Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
34.48Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
34.48Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
34.48Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
34.48Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.48Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
34.48Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
34.48Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.48Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
34.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
33.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
33.33Single2Y00Dobutamine2Y00-β1-Dobutamine
33.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
33.33Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
33.33Single3OE9IT1t3OE9-CXCR4-IT1t
33.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
33.33Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
33.33Single5WIUNemonapride5WIU-D4-Nemonapride
33.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
33.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Single6HLLCP999946HLL-NK1-CP99994
33.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
33.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
33.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
33.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
33.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
33.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
33.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
33.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
33.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
33.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7WC6LSD7WC6-5-HT2A-LSD
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GH1Epinephrine8GH1-β2-Epinephrine
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
33.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
33.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single8QOTNanobody E8QOT-μ-Nanobody E
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
33.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
33.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
33.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
33.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
33.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
33.33Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
33.33Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
33.33Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
33.33Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
33.33Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
33.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
32.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
32.35Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
32.35Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
32.35Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
32.35Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
32.26Single7QA8Peptide7QA8-STE2-Peptide
32.26Single7QA8Peptide7QA8-STE2-Peptide
32.26Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
32.26Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
32.26Consensusclass-d_offOrthosteric Ligandste2_off
32.14Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
32.14Single4BV0Neurotensin4BV0-NTS1-Neurotensin
32.14Single4DJHJDTic4DJH-κ-JDTic
32.14Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
32.14Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
32.14Single5X93K-87945X93-ETB-K-8794
32.14Single5XR8AM8415XR8-CB1-AM841
32.14Single5XRAAM115425XRA-CB1-AM11542
32.14Single6J20Aprepitant6J20-NK1-Aprepitant
32.14Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
32.14Single6WGTLSD6WGT-5-HT2A-LSD
32.14Single7B6WCyclazosin7B6W-α1b-Cyclazosin
32.14Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
32.14Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
32.14Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
32.14Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
32.14Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
32.14Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
32.14Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
32.14Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
32.14Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
32.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
32.14Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
32.14Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
32.14Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
32.14Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
32.14Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
32.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
32.14Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
32.14Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
32.14Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
32.14Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
32.14Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
32.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
32.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
32.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
32.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
32.00Single5K2DZM2413855K2D-A2A-ZM241385
32.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
32.00Single6AKXA4R6AKX-CCR5-A4R
32.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
32.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
32.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
32.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
32.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
32.00Single7F8ULintitript7F8U-CCKA-Lintitript
32.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
32.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
32.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
32.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
32.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
32.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
32.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
32.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
32.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
32.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
32.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
32.00Single8GGVEpinephrine8GGV-β2-Epinephrine
32.00Single8GGWEpinephrine8GGW-β2-Epinephrine
32.00Single8GGXEpinephrine8GGX-β2-Epinephrine
32.00Single8GH0Epinephrine8GH0-β2-Epinephrine
32.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
32.00Single8IHKAcifran8IHK-HCA3-Acifran
32.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single8IWESpermidine8IWE-TAAR9-Spermidine
32.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
32.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
31.43Single6FJ3PTH6FJ3-PTH1-PTH
31.43Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
31.43Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
31.03Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
31.03Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.03Single6HLPNetupitant6HLP-NK1-Netupitant
31.03Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
31.03Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
31.03Single6ZG4HTL00099366ZG4-M1-HTL0009936
31.03Single7DFPSpiperone7DFP-D2-Spiperone
31.03Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
31.03Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.03Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.03Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
31.03Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
31.03Consensuschemokine_offOrthosteric Ligandcxcr_off
31.03Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
31.03Consensuscxcr_offOrthosteric Ligandcxcr4_off
31.03Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.03Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.03Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
31.03Consensusnts_onOrthosteric Ligandnts1_on
30.95Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
30.77Single2YDOAdenosine2YDO-A2A-Adenosine
30.77Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
30.77Single4MBSMaraviroc4MBS-CCR5-Maraviroc
30.77Single5IU7Q274563465IU7-A2A-Q27456346-Na
30.77Single5JTBZM2413855JTB-A2A-ZM241385
30.77Single5K2BZM2413855K2B-A2A-ZM241385-Na
30.77Single5UVIZM2413855UVI-A2A-ZM241385
30.77Single6AQFZM2413856AQF-A2A-ZM241385
30.77Single6DS0Ly2660976DS0-5-HT2B-Ly266097
30.77Single6IQLL7458706IQL-D4-L745870
30.77Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
30.77Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
30.77Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
30.77Single6TP3Nemorexant6TP3-OX1-Nemorexant
30.77Single6TPNHTL66416TPN-OX2-HTL6641
30.77Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
30.77Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
30.77Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
30.77Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
30.77Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
30.77Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
30.77Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
30.77Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
30.77Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
30.77Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
30.77Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
30.77Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
30.77Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single7T32ZM2413857T32-A2A-ZM241385
30.77Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GGIEpinephrine8GGI-β2-Epinephrine
30.77Single8GGKEpinephrine8GGK-β2-Epinephrine
30.77Single8GGMEpinephrine8GGM-β2-Epinephrine
30.77Single8GGPEpinephrine8GGP-β2-Epinephrine
30.77Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
30.77Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
30.77Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
30.77Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
30.77Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
30.77Consensusgnrh_offOrthosteric Ligandgnrh1_off
30.77Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
30.77Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
30.56Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
30.30Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
30.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
30.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
30.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
30.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
30.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
30.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
30.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
29.73Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
29.73Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
29.73Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
29.63Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
29.63Single2Y01Dobutamine2Y01-β1-Dobutamine
29.63Single2Y02Carmoterol2Y02-β1-Carmoterol
29.63Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
29.63Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
29.63Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
29.63Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
29.63Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
29.63Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.63Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
29.63Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
29.63Single6H7MSalbutamol6H7M-β1-Salbutamol
29.63Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
29.63Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
29.63Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
29.63Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
29.63Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
29.63Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.63Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
29.63Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
29.63Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
29.63Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
29.63Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
29.63Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
29.63Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
29.63Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
29.63Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
29.63Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
29.63Single8JJOAlprenolol8JJO-β2-Alprenolol
29.63Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
29.63Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.63Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
29.63Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
29.63Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.63Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
29.63Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
29.63Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
29.63Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
29.63Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
29.63Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
29.63Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
29.63Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
29.63Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
29.63Consensustar_onOrthosteric Ligandta1_on
29.41Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
29.41Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
29.27Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
29.27Consensuspth_onOrthosteric Ligandpth1_on pth2_on
29.17Single3OE6IT1t3OE6-CXCR4-IT1t
29.17Single6ME5Agomelatine6ME5-MT1-Agomelatine
29.17Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
29.17Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.17Single8GGREpinephrine8GGR-β2-Epinephrine
29.17Single8GGZEpinephrine8GGZ-β2-Epinephrine
29.17Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
29.17Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
29.03Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
29.03Consensusclass-d_offOrthosteric Ligandste2_off
29.03Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.57Single5TVNLSD5TVN-5-HT2B-LSD
28.57Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
28.57Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
28.57Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
28.57Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
28.57Single6PS6Timolol6PS6-β2-Timolol
28.57Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.57Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.57Single7C4SS1P7C4S-S1P3-S1P
28.57Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
28.57Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
28.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7YXAONO-54306087YXA-S1P5-ONO-5430608
28.57Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
28.57Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
28.57Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
28.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
28.57Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
28.57Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
28.21Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
28.21Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
28.21Consensusglp_onOrthosteric Ligandglp1_on glp2_on
28.12Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.00Single3PBLEticlopride3PBL-D3-Eticlopride
28.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
28.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
28.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
28.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
28.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
28.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
28.00Single8GGSEpinephrine8GGS-β2-Epinephrine
28.00Single8GGYEpinephrine8GGY-β2-Epinephrine
28.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
28.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
28.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
27.91Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.78Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.78Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
27.78Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
27.78Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
27.59Single5TZR-5TZR-FFA1 (GPR40)-MK8666
27.59Single5V54Methiothepin5V54-5-HT1B-Methiothepin
27.59Single5V56TC1145V56-SMO-TC114
27.59Single6E59L-7607356E59-NK1-L-760735
27.59Single7F1TMIP-1a7F1T-CCR5-MIP-1a
27.59Single7W41PD1762527W41-BB2-PD176252
27.59Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.59Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
27.59Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
27.59Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
27.59Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
27.59Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
27.59Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.59Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.59Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
27.59Consensus5ht1_offOrthosteric Ligand5ht1b_off
27.59Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
27.59Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.59Consensusbombesin_offOrthosteric Ligandbb2_off
27.59Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.59Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
27.59Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
27.59Consensushistamine_offOrthosteric Ligandh1_off
27.50Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
27.50Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
27.27Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
27.03Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
27.03Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
27.03Consensusgo_class-b1Orthosteric Ligandgo_crf
27.03Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
27.03Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.92Single3ODUIT1t3ODU-CXCR4-IT1t
26.92Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
26.92Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.92Single5DHHSB-6121115DHH-NOP-SB-612111
26.92Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.92Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.92Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.92Single6KUXRS-799486KUX-α2a-RS-79948
26.92Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
26.92Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.92Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.92Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
26.92Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
26.92Single7BR3Elagolix7BR3-GnRH1-Elagolix
26.92Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
26.92Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
26.92Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
26.92Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
26.92Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
26.92Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
26.92Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
26.92Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
26.92Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
26.92Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
26.92Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.92Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.92Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
26.92Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
26.92Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
26.92Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.92Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
26.92Consensusalpha1_onOrthosteric Ligandalpha1a_on
26.92Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
26.92Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
26.92Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
26.92Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.92Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
26.83Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
26.83Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
26.83Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
26.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
26.67Single4N4WSANT-14N4W-SMO-SANT-1
26.67Single6CM4Risperidone6CM4-D2-Risperidone
26.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
26.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
26.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.67Consensusgi_class-fOther Ligandgi_frizzled
26.67Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.67Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
26.47Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
26.32Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
26.32Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
26.32Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
26.32Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
25.93Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
25.93Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.93Single6TPKRetosiban6TPK-OT-Retosiban
25.93Single6VI4JDTic6VI4-κ-JDTic
25.93Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
25.93Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.93Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.93Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
25.93Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
25.93Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
25.93Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.93Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.93Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
25.93Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.93Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.93Single8GGLEpinephrine8GGL-β2-Epinephrine
25.93Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
25.93Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
25.93Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
25.93Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
25.93Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
25.93Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
25.93Consensus5ht5_onOrthosteric Ligand5ht5a_on
25.93Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.93Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.93Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
25.93Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
25.93Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.93Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.93Consensusvasopressin-ot_offOrthosteric Ligandot_off
25.81Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.81Single6K1QIRL25006K1Q-ETB-IRL2500
25.81Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
25.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
25.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.71Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
25.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
25.64Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single5T04Neurotensin5T04-NTS1-Neurotensin
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Single6KNMJN241-96KNM-Apelin-JN241-9
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
25.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
25.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
25.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
25.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X64Desloratadine8X64-H1-Desloratadine
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
25.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
24.39Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
24.32Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
24.32Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
24.32Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
24.32Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
24.32Consensusclass-d_onOrthosteric Ligandste2_on
24.32Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
24.24Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.24Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.24Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
24.24Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
24.14Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
24.14Single4NTJAZD12834NTJ-P2Y12-AZD1283
24.14Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
24.14Single5XPRBosentan5XPR-ETB-Bosentan
24.14Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
24.14Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
24.14Single6GPXMK08126GPX-CCR2-MK0812
24.14Single6LUQHaloperidol6LUQ-D2-Haloperidol
24.14Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
24.14Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
24.14Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
24.14Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
24.14Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
24.14Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
24.14Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
24.14Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
24.14Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
24.14Consensusep_offOrthosteric Ligandep4_off
24.00Single3OE8IT1t3OE8-CXCR4-IT1t
24.00Single3UZAGTPL92363UZA-A2A-GTPL9236
24.00Single4XNWMRS25004XNW-P2Y1-MRS2500
24.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
24.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
24.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
24.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
24.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
24.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
24.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
24.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
23.68Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.68Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
23.68Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.68Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
23.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
23.68Consensusgi_class-dOrthosteric Ligandgi_ste
23.68Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.68Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
23.53Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
23.40Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
23.33Single4U15Tiotropium4U15-M3-Tiotropium
23.33Single5V57TC1145V57-SMO-TC114
23.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
23.33Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
23.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.33Single6OL9Tiotropium6OL9-M5-Tiotropium
23.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.33Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
23.33Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
23.33Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
23.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
23.33Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
23.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
23.33Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
23.33Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
23.26Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
23.08Single4O9RCyclopamine4O9R-SMO-Cyclopamine
23.08Single5L7IVismodegib5L7I-SMO-Vismodegib
23.08Single6LMLGlucagon6LML-Glucagon-Glucagon
23.08Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.08Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.08Single7SRQLSD7SRQ-5-HT2B-LSD
23.08Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.08Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
23.08Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
23.08Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.08Consensusclass-t_onOrthosteric Ligandtaste2_on
23.08Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
23.08Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
23.08Consensusgs_class-tOrthosteric Ligandgs_taste
23.08Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.08Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.08Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.08Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
22.73Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
22.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.58Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.58Single5CXVTiotropium5CXV-M1-Tiotropium
22.58Single5X33BIIL2605X33-BLT1-BIIL260
22.58Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
22.58Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.58Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
22.58Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
22.58Consensusclass-b2_onOrthosteric Ligandadgrg_on
22.58Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
22.58Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
22.58Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
22.58Consensusnts_offOrthosteric Ligandnts1_off
22.50Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.50Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
22.50Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
22.50Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
22.22Single4QINSAG1.54QIN-SMO-SAG1.5
22.22Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
22.22Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
22.22Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.22Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.22Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
22.22Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
22.22Consensusclass-d_onOrthosteric Ligandste2_on
22.22Consensusclass-f_offOrthosteric Ligandsmo_off
22.22Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Consensusgi_class-dOrthosteric Ligandgi_ste
22.22Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
22.22Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
22.22Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgt_class-aOrthosteric Ligandgt_opsin
22.22Consensusgt_opsinOrthosteric Ligandgt_sensory
22.22Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
21.88Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.88Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
21.88Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
21.62Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.62Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Single6A94Zotepine6A94-5-HT2A-Zotepine
21.43Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.43Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.43Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
21.43Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.43Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
21.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
21.43Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
21.43Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
21.43Single8K2WAMG4878K2W-CXCR3-AMG487
21.43Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.43Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
21.43Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgi_class-fOrthosteric Ligandgi_frizzled
21.43Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.43Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
21.21Single5EE7MK08935EE7-Glucagon-MK0893
21.21Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
21.21Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.05Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
21.05Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
21.05Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
20.83Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.83Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.83Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
20.83Single8PWNTheophylline8PWN-A2A-Theophylline
20.69Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
20.69Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
20.69Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
20.69Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
20.69Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.69Single6IIVDaltroban6IIV-TP-Daltroban
20.69Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
20.69Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.69Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.69Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.69Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.69Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
20.69Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.69Single8X63Mepyramine8X63-H1-Mepyramine
20.69Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.69Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
20.69Consensushcar_offOrthosteric Ligandsuccinate_off
20.69Consensushistamine_onOrthosteric Ligandh1_on h4_on
20.69Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
20.69Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
20.69Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
20.69Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.69Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
20.59Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.51Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
20.51Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
20.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
20.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
20.00Single6Z4SSR486926Z4S-NTS1-SR48692
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
20.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
20.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
20.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
20.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
20.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
20.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensussensory_onOrthosteric Ligandopsin_on
19.51Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
19.35Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
19.35Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
19.35Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
19.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
19.35Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
19.35Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
19.35Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
19.35Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
19.35Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
19.35Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
19.23Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
19.23Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
19.23Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
19.23Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
19.23Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
19.23Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
19.23Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
19.23Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.92Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
18.75Single6IIURamatroban6IIU-TP-Ramatroban
18.75Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.75Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
18.75Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
18.75Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
18.75Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
18.75Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
18.52Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.52Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
18.52Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.52Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.52Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
18.52Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
18.52Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.52Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
18.52Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.52Consensusgo_proteinOrthosteric Ligandgo_chemokine
18.52Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.52Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.52Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.42Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.18Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.18Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
18.18Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off
18.18Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
17.95Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
17.86Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
17.86Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
17.86Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
17.86Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.86Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.86Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
17.86Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
17.86Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
17.86Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.86Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.86Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
17.86Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
17.86Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
17.86Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.86Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
17.78Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
17.65Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusgs_class-b2Orthosteric Ligandgs_adgr
17.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
17.50Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
17.24Single3RZECidoxepin3RZE-H1-Cidoxepin
17.24Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
17.24Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.24Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
17.24Single6ZINSR486926ZIN-NTS1-SR48692
17.24Single7VV6C48/807VV6-MRGPRX2-C48/80
17.24Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
17.24Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
17.24Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.24Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.24Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
17.24Consensussensory_offOrthosteric Ligandopsin_off
17.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
17.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.67Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
16.67Single4DAJTiotropium4DAJ-M3-Tiotropium
16.67Single4MQSIperoxo4MQS-M2-Iperoxo
16.67Single4U14Tiotropium4U14-M3-Tiotropium
16.67Single5DSGTiotropium5DSG-M4-Tiotropium
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.67Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
16.67Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.13Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
16.13Single5CGCHTL142425CGC-mGlu5-HTL14242
16.13Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.13Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
16.13Single8EA0Iperoxo8EA0-M3-Iperoxo
16.13Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.13Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
16.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
16.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
16.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.62Single7EPENAM5637EPE-mGlu-NAM563
15.62Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
15.56Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
15.38Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
15.15Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
14.81Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
14.81Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.81Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.81Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.81Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
14.81Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.81Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
14.71Single5CGDHTL142425CGD-mGlu5-HTL14242
14.71Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
14.71Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
14.71Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.63Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
14.29Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
14.29Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
14.29Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
14.29Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Single7UL2SR486927UL2-NTS1-SR48692-Na
14.29Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
14.29Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.29Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
14.29Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.89Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
13.79Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.79Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.79Single5U09Taranabant5U09-CB1-Taranabant
13.79Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
13.79Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
13.79Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
13.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.79Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
13.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
12.90Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
12.82Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.12Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
12.12Single7P2L4YI7P2L-mGlu5-4YI
12.12Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.12Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
12.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
12.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.76Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
11.63Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
11.54Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusclass-c_onOther Ligandgabab_on mglu_on
11.36Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
11.11Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.71Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.71Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.71Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
10.71Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.64Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.64Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.34Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
10.34Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
10.20Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.80Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
9.68Single6FFIMMPEP6FFI-mGlu5-MMPEP
9.68Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.68Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.68Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
9.38Single6FFHFenobam6FFH-mGlu5-Fenobam
9.26Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.89Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
8.89Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.89Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
8.82Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.82Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.57Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.51Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
8.00Single8HS2Fab0468HS2-GPR20-Fab046
7.69Single6W25Ca6W25-MC4-SHU9119-Ca
7.55Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
7.41Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
7.41Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.90Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.52Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.25Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single6D35Cholesterol6D35-SMO-Cholesterol
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.17Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.17Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.17Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.17Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.17Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.17Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7FIIhCG7FII-LH-hCG-6fuf
4.17Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.17Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.17Single7XW7K1-707XW7-TSH-K1-70
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.17Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.17Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.17Consensusclass-c_offOther Ligandgabab_off mglu_off
4.17Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.17Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.17Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.17Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.17Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.17Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.17Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.17Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.17Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusgphr_onOrthosteric Ligandlh_on tsh_on
4.17Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Consensusgs_proteinOrthosteric Ligandgs_gphr
4.17Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.17Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.17Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.17Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.17Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.17Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.17Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.17Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.17Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.17Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.17Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.17Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.17Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.85Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.85Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.70Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.70Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
3.70Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.70Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.70Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.70Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.57Single5L7DCholesterol5L7D-SMO-Cholesterol
3.57Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.57Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.45Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
3.33Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.33Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
3.33Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
3.12Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
3.03Single8IYXYL-3658IYX-GPR34-YL-365
2.70Single7SHEPI; PE7SHE-GPR158-PI; PE
2.63Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.44Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
gq_cck 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
gq_angiotensin 7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
gq_bombesin 7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
gq_bradykinin 7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
Net Summary
Imin 2.96625
Number of Linked Nodes 1054
Number of Links 1240
Number of Hubs 179
Number of Links mediated by Hubs 725
Number of Communities 22
Number of Nodes involved in Communities 228
Number of Links involved in Communities 340
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 7327947
Length Of Smallest Path 3
Average Path Length 47.778
Length of Longest Path 86
Minimum Path Strength 0.405
Average Path Strength 5.68892
Maximum Path Strength 23.5137
Minimum Path Correlation 0.7
Average Path Correlation 0.986086
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.25
Average % Of Corr. Nodes 22.1118
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.3292
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gq_class-agq_amine
gq_peptide



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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