Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N23 10.8425447
2A:A:Y37 8.335414
3A:A:H41 6.725426
4A:A:F219 6.115628
5A:A:F222 6.5425407
6A:A:K233 7.7225439
7A:A:W234 7.264509
8A:A:F238 9.5825409
9A:A:N254 6.4385199
10A:A:R265 8.9275409
11A:A:Q267 3.6875404
12A:A:L272 4.8454178
13A:A:F273 5.8325209
14A:A:W277 8.6645206
15A:A:W281 7.9075415
16A:A:L289 5.5775409
17A:A:L291 5.1075408
18A:A:L302 7.04402
19A:A:F312 7.3054148
20A:A:E314 7.7954146
21A:A:F315 8.17406
22A:A:P321 5.1925405
23A:A:E327 8.485484
24A:A:K338 8.2825485
25A:A:Y339 6.5275403
26A:A:F340 10.4785147
27A:A:R342 6.9175484
28A:A:E344 6.71254145
29A:A:F345 7.51408
30A:A:Y358 5.62254214
31A:A:Y360 8.9825408
32A:A:F363 7.2625485
33A:A:R374 7.595404
34A:A:F376 6.654528
35A:A:I383 4.5325428
36A:A:R385 8.3645215
37A:A:L393 3.9475408
38B:B:R22 5.584236
39B:B:L51 7.6075449
40B:B:H54 9.126549
41B:B:K57 9.3675419
42B:B:Y59 9.334518
43B:B:W63 6.19167607
44B:B:V71 4.644168
45B:B:D76 6.885419
46B:B:W82 8.54749
47B:B:D83 8.66448
48B:B:Y85 9.464244
49B:B:N88 10.015447
50B:B:K89 6.255649
51B:B:L95 4.854508
52B:B:W99 8.108509
53B:B:M101 4.78419
54B:B:Y105 5.084297166
55B:B:Y124 5.81406
56B:B:H142 9.445109
57B:B:Y145 5.0175408
58B:B:F151 4.34509
59B:B:T159 6.4525109
60B:B:D163 8.854109
61B:B:W169 10.1385108
62B:B:Q176 7.335404
63B:B:F180 8.7725497
64B:B:R197 4.7175405
65B:B:F199 7.85599
66B:B:V200 6.2025436
67B:B:D205 6.795409
68B:B:K209 10.8175496
69B:B:L210 5.895405
70B:B:W211 9.73598
71B:B:H225 9.51639
72B:B:D228 8.204539
73B:B:F234 4.57505
74B:B:P236 5.66754277
75B:B:F241 9.2375436
76B:B:D246 6.4675439
77B:B:D247 7.818539
78B:B:R251 8.54538
79B:B:F253 7.06667636
80B:B:M262 5.6225404
81B:B:Y264 5.19333605
82B:B:F278 6.8365277
83B:B:R283 7.9965159
84B:B:Y289 6.80167617
85B:B:D290 5.97516
86B:B:N293 4.985405
87B:B:N295 7.4825416
88B:B:W297 5.515418
89B:B:D298 9.13254159
90B:B:L300 6.74754156
91B:B:K301 5.2665155
92B:B:H311 7.322569
93B:B:R314 13.43518
94B:B:M325 7.0675405
95B:B:W332 11.7619
96B:B:D333 7.8469
97B:B:K337 6.24566
98B:B:W339 9.7125469
99G:G:Q18 4.296599
100G:G:R27 5.5885238
101G:G:D48 6.6185289
102G:G:L51 4.0775406
103G:G:F61 5.9045248
104R:R:I47 3.5625408
105R:R:N51 5.2775409
106R:R:F61 5.998336296
107R:R:F71 5.32508
108R:R:L75 5.224119
109R:R:D79 6.485119
110R:R:L80 5.31407
111R:R:V86 6.21457
112R:R:W99 8.436127
113R:R:F101 7.835405
114R:R:W109 5.664125
115R:R:T118 5.8325406
116R:R:D130 7.8575428
117R:R:Y132 7.7025408
118R:R:P138 4.7025428
119R:R:F139 6.52333626
120R:R:Y141 6.91527
121R:R:F166 6.016676134
122R:R:I169 5.016575
123R:R:Y174 8.2475
124R:R:H178 6.13472
125R:R:Y185 9.4875471
126R:R:T189 5.8925404
127R:R:F194 7.314571
128R:R:Y199 5.36833676
129R:R:F208 10.698508
130R:R:Y209 5.9254315
131R:R:Y219 5.5075409
132R:R:R221 5.175405
133R:R:F282 5.11459
134R:R:W286 7.49758
135R:R:L287 5.18406
136R:R:F289 10.072556
137R:R:F290 9.1225457
138R:R:W313 8.48455
139R:R:Y316 7.60286756
140R:R:N322 5.075119
141R:R:Y326 5.95254119
142R:R:F332 4.616676309
143L:L:?1 8.721050
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F238 B:B:W99 99.772612.03YesYes099
2A:A:F238 A:A:L44 49.87417.05YesNo099
3A:A:L44 A:A:L46 49.90385.54NoNo098
4A:A:L272 A:A:L46 49.87954.15YesNo1788
5A:A:F246 A:A:L272 1006.09NoYes098
6A:A:F246 A:A:L289 99.97534.87NoYes099
7A:A:L289 A:A:L291 91.68894.15YesYes098
8A:A:F363 A:A:L291 91.81467.31YesYes058
9A:A:F363 A:A:R342 91.54919.62YesYes854
10A:A:L346 A:A:R342 90.93963.64NoYes844
11A:A:L346 R:R:R239 90.94966.07NoNo044
12A:A:T350 R:R:R239 94.457910.35NoNo044
13A:A:T350 R:R:E237 94.42235.64NoNo043
14A:A:Y358 R:R:E237 94.38664.49YesNo043
15A:A:F238 A:A:W234 50.01084.01YesYes099
16A:A:R232 A:A:W234 50.09179NoYes089
17A:A:L272 A:A:R232 50.10144.86YesNo088
18B:B:D186 B:B:Y145 10.14143.45NoYes098
19B:B:M101 B:B:Y145 10.76337.18YesYes098
20B:B:M101 B:B:Y59 10.9673.59YesYes198
21B:B:W332 B:B:Y59 43.589814.47YesYes198
22B:B:S316 B:B:W332 69.46664.94NoYes099
23B:B:C317 B:B:S316 69.29273.44NoNo079
24B:B:C317 B:B:M61 69.11894.86NoNo076
25B:B:M61 B:B:W63 68.94536.98NoYes067
26B:B:R314 B:B:W332 17.817528.99YesYes189
27B:B:D290 B:B:R314 16.452211.91YesYes168
28A:A:Y358 R:R:I233 87.45586.04YesNo2146
29A:A:L394 R:R:I233 89.11954.28NoNo086
30A:A:L388 A:A:L394 89.03744.15NoNo088
31A:A:L388 A:A:L393 83.16035.54NoYes088
32A:A:L393 R:R:L275 82.80664.15YesNo088
33B:B:C271 B:B:D290 16.08054.67NoYes156
34B:B:C271 B:B:Y289 15.10245.38NoYes157
35B:B:W297 B:B:Y289 12.75525.79YesYes187
36B:B:W297 B:B:Y264 11.98526.75YesYes085
37B:B:D83 B:B:R68 23.877216.68YesNo085
38B:B:R68 B:B:Y85 47.866715.43NoYes054
39B:B:M325 G:G:P49 18.26588.39YesNo057
40G:G:D48 G:G:P49 18.07223.22YesNo097
41G:G:D48 G:G:L50 13.40554.07YesNo2899
42B:B:V327 G:G:L50 13.21254.47NoNo069
43B:B:V320 B:B:V327 12.04046.41NoNo076
44B:B:S277 B:B:V320 11.84494.85NoNo057
45B:B:L318 B:B:S277 11.45363NoNo065
46B:B:L318 B:B:T329 11.06214.42NoNo068
47B:B:K57 B:B:Q75 42.181912.2YesNo199
48B:B:D83 B:B:L69 24.14274.07YesNo085
49B:B:L69 B:B:Y105 47.38425.86NoYes056
50B:B:V71 B:B:Y105 11.16537.57YesYes1686
51B:B:H62 B:B:Y105 33.3443.27NoYes066
52B:B:H62 B:B:R150 32.963314.67NoNo066
53B:B:S84 B:B:W63 49.14254.94NoYes057
54B:B:S84 B:B:Y85 48.41045.09NoYes2454
55B:B:T321 B:B:W63 18.557512.13NoYes077
56B:B:C148 B:B:R150 15.38815.57NoNo066
57B:B:C148 B:B:T102 15.00463.38NoNo068
58B:B:C149 B:B:T102 14.6216.76NoNo088
59B:B:C149 B:B:T159 14.23745.07NoYes089
60B:B:T159 B:B:W169 10.39199.7YesYes1098
61B:B:D66 B:B:R68 23.80945.96NoNo085
62B:B:D66 B:B:L69 23.6225.43NoNo085
63B:B:D323 B:B:T321 18.169810.12NoNo2577
64B:B:L192 B:B:R150 17.30484.86NoNo056
65B:B:F199 B:B:L192 11.9313.65YesNo095
66R:R:L275 R:R:Y219 82.69565.86NoYes089
67R:R:A128 R:R:Y219 41.31125.34NoYes089
68R:R:A128 R:R:M215 41.25494.83NoNo088
69R:R:F282 R:R:M215 82.37734.98YesNo098
70R:R:F208 R:R:F282 21.84526.43YesYes089
71R:R:F208 R:R:F290 19.021415YesYes087
72L:L:?1 R:R:F290 37.80655.9YesYes507
73R:R:M279 R:R:Y219 41.31125.99NoYes089
74R:R:M215 R:R:M279 41.25495.78NoNo088
75R:R:F282 R:R:W286 59.75244.01YesYes598
76R:R:F290 R:R:W286 19.21127.02YesYes578
77R:R:V117 R:R:W286 19.1559.81NoYes068
78L:L:?1 R:R:V117 19.00278.41YesNo006
79R:R:F289 R:R:W286 21.94537.02YesYes568
80L:L:?1 R:R:F289 19.034310.81YesYes506
81L:L:?1 R:R:V114 31.19686.01YesNo005
82R:R:V114 R:R:Y199 30.57543.79NoYes056
83R:R:I169 R:R:Y199 28.75273.63YesYes756
84R:R:I169 R:R:T110 23.73813.04YesNo054
85R:R:T110 R:R:W109 22.48932.43NoYes045
86L:L:?1 R:R:S203 31.19687.27YesNo005
87R:R:S203 R:R:Y199 30.57547.63NoYes056
88R:R:W109 R:R:W99 18.7426.56YesYes1257
89R:R:Y174 R:R:Y199 26.17893.97YesYes756
90R:R:Y174 R:R:Y185 22.46127.94YesYes751
91R:R:F194 R:R:Y185 14.97597.22YesYes711
92B:B:K57 B:B:W332 42.132212.76YesYes199
93B:B:Q75 B:B:Y59 51.418413.53NoYes198
94B:B:D323 B:B:M325 18.00466.93NoYes075
95B:B:Q75 B:B:W99 93.6566.57NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 7.61 5 No Yes 7 7 2 2
R:R:M82 R:R:Y316 3.59 5 No Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 5 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 5 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 3.68 5 No Yes 7 5 2 2
R:R:V87 R:R:Y316 3.79 5 No Yes 7 6 2 1
R:R:D113 R:R:Y316 12.64 5 No Yes 7 6 1 1
L:L:?1 R:R:D113 15.33 5 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 6.01 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 5 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 10.38 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 5 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 5 Yes No 0 5 0 1
L:L:?1 R:R:S207 3.63 5 Yes No 0 5 0 1
R:R:F208 R:R:F290 15 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 5 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 5 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 12.79 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 5 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 5 Yes Yes 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
100.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GGIEpinephrine8GGI-β2-Epinephrine
100.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single6H7MSalbutamol6H7M-β1-Salbutamol
90.91Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
90.91Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
90.91Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GGJEpinephrine8GGJ-β2-Epinephrine
90.91Single8GGNEpinephrine8GGN-β2-Epinephrine
90.91Single8GGOEpinephrine8GGO-β2-Epinephrine
90.91Single8GGUEpinephrine8GGU-β2-Epinephrine
90.91Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
90.91Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
90.91Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
90.91Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
90.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
90.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GGVEpinephrine8GGV-β2-Epinephrine
90.00Single8GGWEpinephrine8GGW-β2-Epinephrine
90.00Single8GGXEpinephrine8GGX-β2-Epinephrine
90.00Single8GH0Epinephrine8GH0-β2-Epinephrine
90.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
83.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
83.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
83.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
83.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
83.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
83.33Single7XKAEpinephrine7XKA-β2-Epinephrine
83.33Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
83.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
83.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
83.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
83.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
83.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
83.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
83.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
83.33Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
83.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
81.82Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
81.82Single6PS4ICI 118-5516PS4-β2-ICI 118-551
81.82Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
81.82Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
81.82Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGKEpinephrine8GGK-β2-Epinephrine
81.82Single8GGMEpinephrine8GGM-β2-Epinephrine
81.82Single8GGPEpinephrine8GGP-β2-Epinephrine
81.82Single8GGQEpinephrine8GGQ-β2-Epinephrine
81.82Single8GGTEpinephrine8GGT-β2-Epinephrine
81.82Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
81.82Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
80.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GGSEpinephrine8GGS-β2-Epinephrine
80.00Single8GGYEpinephrine8GGY-β2-Epinephrine
80.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
76.92Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
76.92Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
76.92Single6H7JIsoprenaline6H7J-β1-Isoprenaline
76.92Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
76.92Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
76.92Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
76.92Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
76.92Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
76.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
76.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
76.92Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
76.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
75.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
75.00Single2Y04Salbutamol2Y04-β1-Salbutamol
75.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
75.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
75.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
75.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
75.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
75.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
75.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
75.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
75.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
75.00Single6PS1Timolol6PS1-β2-Timolol
75.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
75.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
75.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
75.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
75.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
75.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
75.00Single8JJOAlprenolol8JJO-β2-Alprenolol
75.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
75.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
75.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
75.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
75.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
75.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
75.00Consensustar_onOrthosteric Ligandta1_on
72.73Single6KUXRS-799486KUX-α2a-RS-79948
72.73Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
72.73Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
72.73Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
72.73Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
72.73Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
72.73Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
72.73Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
72.73Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
72.73Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
72.73Consensusalpha1_onOrthosteric Ligandalpha1a_on
72.73Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
72.73Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
71.43Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
71.43Single4AMIBucindolol4AMI-β1-Bucindolol
71.43Single4LDEBI1671074LDE-β2-BI167107
71.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
71.43Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
71.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
71.43Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
71.43Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
71.43Single8JJ8Formoterol8JJ8-β2-Formoterol
71.43Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
70.00Single8GGREpinephrine8GGR-β2-Epinephrine
70.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
70.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
69.23Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
69.23Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
69.23Single5WIUNemonapride5WIU-D4-Nemonapride
69.23Single5WIVNemonapride5WIV-D4-Nemonapride-Na
69.23Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
69.23Single6E67BI1671076E67-β2-BI167107-Gs (fused)
69.23Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
69.23Single7WC6LSD7WC6-5-HT2A-LSD
69.23Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
69.23Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
69.23Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
69.23Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
69.23Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
69.23Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
66.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
66.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
66.67Single6A94Zotepine6A94-5-HT2A-Zotepine
66.67Single6H7LDobutamine6H7L-β1-Dobutamine
66.67Single6IBLArformoterol6IBL-β1-Arformoterol
66.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
66.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
66.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single8GGLEpinephrine8GGL-β2-Epinephrine
66.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
66.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
66.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
66.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single2YDVNECA2YDV-A2A-NECA
64.29Single3P0GBI1671073P0G-β2-BI167107
64.29Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
64.29Single4U15Tiotropium4U15-M3-Tiotropium
64.29Single4UHRCGS216804UHR-A2A-CGS21680
64.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
64.29Single5G53NECA5G53-A2A-NECA-Gs
64.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
64.29Single6OL9Tiotropium6OL9-M5-Tiotropium
64.29Single6WGTLSD6WGT-5-HT2A-LSD
64.29Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
64.29Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
64.29Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
64.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
64.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
64.29Consensus5ht5_offOrthosteric Ligand5ht5a_off
64.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
64.29Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.29Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
64.29Consensushistamine_offOrthosteric Ligandh1_off
64.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
64.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
63.64Single3PBLEticlopride3PBL-D3-Eticlopride
63.64Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
63.64Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
63.64Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
63.64Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
63.64Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
63.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
63.64Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
63.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
62.50Single3NY9PubChem 9131033NY9-β2-PubChem 913103
62.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single2Y01Dobutamine2Y01-β1-Dobutamine
61.54Single2Y02Carmoterol2Y02-β1-Carmoterol
61.54Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
61.54Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
61.54Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
61.54Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
61.54Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
61.54Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
61.54Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
61.54Single7BU7BI1671077BU7-β1-BI167107
61.54Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
61.54Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
61.54Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
61.54Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
61.54Single8X64Desloratadine8X64-H1-Desloratadine
61.54Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
61.54Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
61.54Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
61.54Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
61.54Consensushistamine_onOrthosteric Ligandh1_on h4_on
60.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
60.00Single5CXVTiotropium5CXV-M1-Tiotropium
60.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
60.00Single6MXTSalmeterol6MXT-β2-Salmeterol
60.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
60.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
60.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
60.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
60.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
60.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
58.82Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
58.82Single4IARErgotamine4IAR-5-HT1B-Ergotamine
58.82Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
58.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
58.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
58.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
58.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
58.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8IWESpermidine8IWE-TAAR9-Spermidine
58.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
58.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single2Y00Dobutamine2Y00-β1-Dobutamine
57.14Single5C1MBU725C1M-μ-BU72
57.14Single5TVNLSD5TVN-5-HT2B-LSD
57.14Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
57.14Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
57.14Single6PS6Timolol6PS6-β2-Timolol
57.14Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
57.14Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
57.14Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
57.14Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
57.14Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
57.14Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
56.25Single7UM4AS26747237UM4-5-HT5A-AS2674723
56.25Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
56.25Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
56.25Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
56.25Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
54.55Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
54.55Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
54.55Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
53.85Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
53.85Single6TPGEMPA6TPG-OX2-EMPA
53.85Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
53.85Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
53.85Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.85Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
53.85Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
53.85Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
53.85Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
53.85Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
53.85Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
53.85Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.85Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
53.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
53.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
53.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
53.33Single6J21Aprepitant6J21-NK1-Aprepitant
53.33Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
53.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
53.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
53.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
53.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
53.33Single8E0GBU728E0G-μ-BU72
53.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
53.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
53.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
53.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
53.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
53.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.94Single4UG2CGS216804UG2-A2A-CGS21680
52.94Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single4DAJTiotropium4DAJ-M3-Tiotropium
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4MQSIperoxo4MQS-M2-Iperoxo
50.00Single4U14Tiotropium4U14-M3-Tiotropium
50.00Single5DSGTiotropium5DSG-M4-Tiotropium
50.00Single6CM4Risperidone6CM4-D2-Risperidone
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
50.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
50.00Single7UL4Alvimopan7UL4-μ-Alvimopan
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
50.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
50.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GH1Epinephrine8GH1-β2-Epinephrine
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
50.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
50.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
47.37Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
47.37Single6HLOAprepitant6HLO-NK1-Aprepitant
47.06Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.06Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.06Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.06Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.06Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.06Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.06Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
47.06Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.06Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
47.06Consensusendothelin_offOrthosteric Ligandetb_off
47.06Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
47.06Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
46.67Single5WQCEMPA5WQC-OX2-EMPA
46.67Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
46.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
46.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
46.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
46.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Single8EA0Iperoxo8EA0-M3-Iperoxo
46.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
46.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
46.67Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
46.67Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.15Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
46.15Single6AKXA4R6AKX-CCR5-A4R
46.15Single6AKYMaraviroc6AKY-CCR5-Maraviroc
46.15Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.15Single6TODEMPA6TOD-OX1-EMPA-Na
46.15Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.15Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
46.15Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.15Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
46.15Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.15Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.15Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
45.45Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
45.45Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
45.45Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.45Consensussensory_onOrthosteric Ligandopsin_on
44.44Single6PT3DPI-2876PT3-δ-DPI-287
44.44Single7SK9CCX6627SK9-ACKR3-CCX662
43.75Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
43.75Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
43.75Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
43.75Single5X93K-87945X93-ETB-K-8794
43.75Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
43.75Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
43.75Single6J20Aprepitant6J20-NK1-Aprepitant
43.75Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
43.75Single7B6WCyclazosin7B6W-α1b-Cyclazosin
43.75Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
43.75Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
43.75Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
43.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
43.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
43.75Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
43.75Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
43.75Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
43.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
43.75Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
43.75Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
43.75Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
42.86Single2YDOAdenosine2YDO-A2A-Adenosine
42.86Single3RZECidoxepin3RZE-H1-Cidoxepin
42.86Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
42.86Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
42.86Single4MBSMaraviroc4MBS-CCR5-Maraviroc
42.86Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
42.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
42.86Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
42.86Single6TPNHTL66416TPN-OX2-HTL6641
42.86Single6VI4JDTic6VI4-κ-JDTic
42.86Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
42.86Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
42.86Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
42.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
42.86Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
42.86Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
42.86Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
42.86Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
42.11Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.11Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
42.11Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.67Single3UZAGTPL92363UZA-A2A-GTPL9236
41.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
41.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
41.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.18Single6A93Risperidone6A93-5-HT2A-Risperidone
41.18Single6HLPNetupitant6HLP-NK1-Netupitant
41.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
41.18Single7DFPSpiperone7DFP-D2-Spiperone
41.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
41.18Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
41.18Consensusgs_steroidOrthosteric Ligandgs_bileacid
40.91Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
40.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
40.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
40.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
40.00Single6TOTLemborexant6TOT-OX1-Lemborexant
40.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
40.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
40.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
40.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
40.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
40.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
40.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
40.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
40.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Consensusgi_hcarOrthosteric Ligandgi_hca
40.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
40.00Consensustachykinin_offOrthosteric Ligandnk1_off
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single7EZCUKA7EZC-A2A-UKA
38.89Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.89Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
38.89Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensussteroid_onOrthosteric Ligandbileacid_on
38.46Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
38.46Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
38.46Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
38.46Single6HLLCP999946HLL-NK1-CP99994
38.46Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
38.46Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
38.46Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
38.46Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
38.46Single8K5BNiacin8K5B-HCA2-Niacin
38.46Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
38.46Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
38.10Single5WF5UK-4320975WF5-A2A-UK-432097
38.10Single6PT2KGCHM076PT2-δ-KGCHM07
38.10Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
37.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single5XPRBosentan5XPR-ETB-Bosentan
37.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
37.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
37.50Single6TP6Filorexant6TP6-OX1-Filorexant
37.50Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
37.50Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
37.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
37.50Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
37.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Single5WF6UK-4320975WF6-A2A-UK-432097
36.84Single7XN9L-054,5227XN9-SST2-L-054,522
36.84Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
36.84Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.84Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
36.36Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
36.36Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
36.36Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.71Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.71Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
35.71Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
35.71Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
35.71Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
35.71Single5DHHSB-6121115DHH-NOP-SB-612111
35.71Single5WS3EMPA5WS3-OX2-EMPA
35.71Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
35.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.71Consensusgt_class-aOrthosteric Ligandgt_opsin
35.71Consensusgt_opsinOrthosteric Ligandgt_sensory
35.71Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.71Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
35.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.29Single4DJHJDTic4DJH-κ-JDTic
35.29Single6E59L-7607356E59-NK1-L-760735
35.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.29Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.29Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
35.29Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
35.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
35.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
35.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.29Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
35.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
35.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7T32ZM2413857T32-A2A-ZM241385
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
33.33Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
33.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WU1KCA8WU1-CB1-KCA-Arrestin1
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensussensory_offOrthosteric Ligandopsin_off
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
31.82Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
31.82Consensusangiotensin_onOrthosteric Ligandat1_on
31.82Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
31.82Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
31.58Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
31.58Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.58Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.58Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
31.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.58Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
31.58Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
31.58Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusorexin_onOrthosteric Ligandox2_on
31.25Single4YAYZD-71554YAY-AT1-ZD-7155
31.25Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
31.25Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
31.25Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.25Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
31.25Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.25Single8CU6LJ-45178CU6-A2A-LJ-4517
31.25Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.25Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.25Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8K5DGSK2560738K5D-HCA2-GSK256073
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.25Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusblt_onOrthosteric Ligandblt1_on
31.25Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusleuko_onOrthosteric Ligandblt_on
30.77Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
30.77Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
30.77Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single6ME5Agomelatine6ME5-MT1-Agomelatine
30.77Single6ME9Ramelteon6ME9-MT2-Ramelteon
30.77Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
30.77Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
30.77Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
30.43Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5ZTYAM102575ZTY-CB2-AM10257
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
30.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
29.63Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
29.41Single5CGCHTL142425CGC-mGlu5-HTL14242
29.41Single5NM2ZM2413855NM2-A2A-ZM241385-Na
29.41Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.41Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.41Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
29.41Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
29.17Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.57Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
28.57Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
28.57Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
28.57Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
28.57Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
28.57Single6TP4ACT-4622066TP4-OX1-ACT-462206
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7F8XNN90567F8X-CCKA-NN9056
28.57Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
28.57Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.57Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
28.57Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single5XR8AM8415XR8-CB1-AM841
27.78Single7EPENAM5637EPE-mGlu-NAM563
27.78Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
27.78Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
27.78Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
27.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
27.78Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
27.78Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.78Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
27.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.78Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
27.78Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.78Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.27Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
27.27Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
27.27Single5MZPCaffeine5MZP-A2A-Caffeine-Na
27.27Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
27.27Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.92Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
26.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single5K2DZM2413855K2D-A2A-ZM241385
26.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.67Single6JZHZM2413856JZH-A2A-ZM241385-Na
26.67Single6PS7ZM2413856PS7-A2A-ZM241385-Na
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single7F8ULintitript7F8U-CCKA-Lintitript
26.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.67Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
26.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.67Single7XRRLemborexant7XRR-OX2-Lemborexant
26.67Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
26.67Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
26.67Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
26.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.67Single8IHKAcifran8IHK-HCA3-Acifran
26.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.32Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
26.32Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.32Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
26.32Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.32Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.32Single7K15MKD0467K15-BLT1-MKD046-Na
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
26.32Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
26.32Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
26.32Consensusblt_offOrthosteric Ligandblt1_off
26.32Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
26.32Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.32Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
26.32Consensusdp_offOrthosteric Liganddp2_off
26.32Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.32Consensusgi_class-fOther Ligandgi_frizzled
26.32Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
26.32Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
26.32Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.09Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.93Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
25.00Single3REYPubChem 56973REY-A2A-PubChem 5697
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single5CGDHTL142425CGD-mGlu5-HTL14242
25.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5JTBZM2413855JTB-A2A-ZM241385
25.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
25.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
25.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
25.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.00Consensuss1p_offOrthosteric Ligands1p1_off
24.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
24.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
24.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single5EE7MK08935EE7-Glucagon-MK0893
23.81Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
23.81Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
23.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
23.81Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.53Single3EMLZM2413853EML-A2A-ZM241385
23.53Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.53Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.53Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.53Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.53Single5TGZAM65385TGZ-CB1-AM6538
23.53Single5UENDU1725UEN-A1-DU172
23.53Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.53Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.53Single6D27CAY104716D27-DP2-CAY10471
23.53Single6GPSMK08126GPS-CCR2-MK0812
23.53Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.53Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.53Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.53Single6S0LZM2413856S0L-A2A-ZM241385
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.53Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
23.53Single7PYRPSB-21157PYR-A2A-PSB-2115
23.53Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.53Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
23.53Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
23.53Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.53Consensusa2_offOrthosteric Liganda2a_off
23.53Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.53Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.53Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.53Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.08Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
23.08Single3RFMCaffeine3RFM-A2A-Caffeine
23.08Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.08Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.08Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
23.08Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.73Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
22.73Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
22.73Consensusclass-d_offOrthosteric Ligandste2_off
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.73Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.58Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.22Single6GPXMK08126GPX-CCR2-MK0812
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.22Single6S0QZM2413856S0Q-A2A-ZM241385
22.22Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.22Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.22Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
22.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Single8QOTNanobody E8QOT-μ-Nanobody E
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.22Consensusgo_class-b1Orthosteric Ligandgo_crf
22.22Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.74Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
21.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
21.74Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
21.74Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.43Single6IGLIRL16206IGL-ETB-IRL1620
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.43Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
21.43Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.43Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.43Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
21.43Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.43Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.43Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
21.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
21.05Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single7PX4PSB-21137PX4-A2A-PSB-2113
21.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
21.05Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.05Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
21.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
21.05Consensuscck_onOrthosteric Ligandccka_on cckb_on
21.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensuschemerin_onOrthosteric Ligandcml1_on
21.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.05Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.05Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.05Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.05Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
21.05Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.83Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.83Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
20.83Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
20.83Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.83Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.69Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.69Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.69Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Consensusclass-d_onOrthosteric Ligandste2_on
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
19.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.23Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
19.23Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
19.23Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.23Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single6K1QIRL25006K1Q-ETB-IRL2500
19.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
19.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
19.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
19.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.05Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
19.05Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.75Single3PWHZM2413853PWH-A2A-ZM241385
18.75Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.75Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.75Consensusmglu_onOther Ligandmglu2_on mglu4_on
18.52Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.52Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.52Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
18.18Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
17.86Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.86Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.65Single5UVIZM2413855UVI-A2A-ZM241385
17.65Single6FFIMMPEP6FFI-mGlu5-MMPEP
17.65Single6MH8ZM2413856MH8-A2A-ZM241385
17.65Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.65Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.65Single6TPKRetosiban6TPK-OT-Retosiban
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.65Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.65Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.65Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.65Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.65Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
17.65Consensusvasopressin-ot_offOrthosteric Ligandot_off
17.39Single4XT1Fractalkine4XT1-US28-Fractalkine
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
17.39Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.39Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6LMLGlucagon6LML-Glucagon-Glucagon
17.24Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.24Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.14Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.14Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single6FFHFenobam6FFH-mGlu5-Fenobam
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.67Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.67Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensuscck_offOrthosteric Ligandccka_off
16.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.67Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
16.67Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensushcar_offOrthosteric Ligandsuccinate_off
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
16.67Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
16.67Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
16.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.67Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
16.67Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
16.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.13Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.13Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.13Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.00Single3OE0CVX153OE0-CXCR4-CVX15
16.00Single6W25SHU91196W25-MC4-SHU9119-Ca
16.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.79Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.79Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.79Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.79Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.79Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.79Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.79Consensusep_offOrthosteric Ligandep4_off
15.79Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.79Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
15.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
15.38Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
15.38Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.38Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.15Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.00Single7P2L4YI7P2L-mGlu5-4YI
15.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single4XT3Fractalkine4XT3-US28-Fractalkine
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
14.29Single6FJ3PTH6FJ3-PTH1-PTH
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
14.29Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
14.29Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
14.29Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
14.29Consensusclass-b2_onOrthosteric Ligandadgrg_on
14.29Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.29Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.79Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.64Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.64Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.64Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
13.64Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.51Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
13.33Single3OE6IT1t3OE6-CXCR4-IT1t
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.33Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.16Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.04Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.04Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.82Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
12.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.50Consensusclass-t_onOrthosteric Ligandtaste2_on
12.50Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Consensusgo_class-b2Orthosteric Ligandgo_adhesion
12.50Consensusgs_class-tOrthosteric Ligandgs_taste
12.50Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.50Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.00Single7SK5CXCL127SK5-ACKR3-CXCL12
12.00Consensussst_offOrthosteric Ligandsst2_off
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.76Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.76Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.54Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.54Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Single7XNACYN1548067XNA-SST2-CYN154806
11.54Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.43Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.11Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single8K2WAMG4878K2W-CXCR3-AMG487
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.11Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.11Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.53Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.34Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.34Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.34Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.34Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.00Consensusclass-c_offOther Ligandgabab_off mglu_off
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.68Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.52Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.52Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.52Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single6OS2TRV0266OS2-AT1-TRV026
9.09Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.09Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.09Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.82Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.70Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.70Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
8.70Consensuscyslt_offOrthosteric Ligandcyslt2_off
8.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.33Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.33Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusgs_class-b2Orthosteric Ligandgs_adgr
8.33Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
7.69Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.69Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.69Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.41Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.14Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Consensusclass-c_onOther Ligandgabab_on mglu_on
7.14Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.67Single7SK3CXCL127SK3-ACKR3-CXCL12
6.67Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.25Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.25Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.88Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.88Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.56Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.56Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.26Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.26Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.26Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.26Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.76Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.76Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single5V56TC1145V56-SMO-TC114
4.55Single5V57TC1145V57-SMO-TC114
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.35Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.35Single4XESNeurotensin4XES-NTS1-Neurotensin
4.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.35Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.35Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensuschemokine_offOrthosteric Ligandcxcr_off
4.35Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.35Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.35Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.35Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.35Consensusnts_offOrthosteric Ligandnts1_off
4.17Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.17Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.85Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.78Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.38Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.38Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8GE6
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand Epinephrine
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.4
Date 2024-03-06
D.O.I. 10.1038/s41586-024-07153-1
Net Summary
Imin 3.42
Number of Linked Nodes 845
Number of Links 980
Number of Hubs 143
Number of Links mediated by Hubs 544
Number of Communities 32
Number of Nodes involved in Communities 198
Number of Links involved in Communities 258
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 3862089
Length Of Smallest Path 3
Average Path Length 41.8984
Length of Longest Path 67
Minimum Path Strength 1.225
Average Path Strength 6.74769
Maximum Path Strength 21.99
Minimum Path Correlation 0.7
Average Path Correlation 0.990002
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 29.4403
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.7592
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8GE6_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKSTI 
VKQGIFETK FQVDKVNFH MFDVGGQRD ERRKWIQCF NDVTAIIFV 
VASSSYNMV ITNRLQEAL NLFKSIWNN RWLRTISVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8GE6_Chain_B
QLRQEAEQL KNQIRDARK ACADATLSQ ITNNIDPVG RIQMRTRRT 
LRGHLAKIY AMHWGTDSR LLVSASQDG KLIIWDSYT TNKVHAIPL 
RSSWVMTCA YAPSGNYVA CGGLDNICS IYNLKTVRV SRELAGHTG 
YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF TGHTGDVMS 
LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH ESDINAICF 
FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII CGITSVSFS 
KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV SCLGVTDDG 
MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8GE6_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GE6_Chain_R
GMGIVMSLI VLAIVFGNV LVITAIAKF ERLQTVTNY FITSLACAD 
LVMGLAVVP FGAAHILTK TWTFGNFWC EFWTSIDVL CVTASIETL 
CVIAVDRYF AITSPFKYQ SLLTKNKAR VIILMVWIV SGLTSFLPI 
QMHWYRATH QEAINCYAE ETCCDFFTN QAYAIASSI VSFYVPLVI 
MVFVYSRVF QEAKRQLQK IDKSEGRHK ALKTLGIIM GTFTLCWLP 
FFIVNIVHV IQDNLIRKE VYILLNWIG YVNSGFNPL IYCRSPDFR 
IAFQELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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