psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W109	2.99	Yes	Yes	1	0	5
2	L:L:?1	R:R:T110	2.9	Yes	Yes	1	0	4
3	L:L:?1	R:R:D113	8.01	Yes	Yes	1	0	7
4	L:L:?1	R:R:V114	1.95	Yes	Yes	1	0	5
5	L:L:?1	R:R:V117	5.86	Yes	No	1	0	6
6	L:L:?1	R:R:T118	1.93	Yes	Yes	1	0	6
7	L:L:?1	R:R:D192	1.78	Yes	No	1	0	3
8	L:L:?1	R:R:F193	17.57	Yes	Yes	1	0	4
9	L:L:?1	R:R:T195	2.9	Yes	Yes	1	0	3
10	L:L:?1	R:R:S203	11.82	Yes	Yes	1	0	5
11	L:L:?1	R:R:S207	5.91	Yes	Yes	1	0	5
12	L:L:?1	R:R:F289	6.39	Yes	Yes	1	0	6
13	L:L:?1	R:R:F290	7.19	Yes	Yes	1	0	7
14	L:L:?1	R:R:N293	2.7	Yes	Yes	1	0	5
15	L:L:?1	R:R:Y308	4.61	Yes	Yes	1	0	5
16	L:L:?1	R:R:I309	4.68	Yes	No	1	0	3
17	L:L:?1	R:R:N312	12.61	Yes	No	1	0	5
18	R:R:E30	R:R:W32	9.81	No	No	0	3	3
19	R:R:V31	R:R:W32	3.68	No	No	0	2	3
20	R:R:V31	R:R:V34	1.6	No	No	0	2	5
21	R:R:V33	R:R:V34	1.6	No	No	0	4	5
22	R:R:G35	R:R:V34	1.84	No	No	0	5	5
23	R:R:G37	R:R:M36	1.75	No	No	0	5	5
24	R:R:M36	R:R:M40	5.78	No	Yes	0	5	6
25	R:R:G37	R:R:L95	3.42	No	No	0	5	6
26	R:R:A91	R:R:M40	4.83	No	Yes	0	6	6
27	R:R:I94	R:R:M40	2.92	No	Yes	1	5	6
28	R:R:M40	R:R:W313	4.65	Yes	Yes	1	6	5
29	R:R:I43	R:R:V317	3.07	No	No	0	6	5
30	R:R:L45	R:R:V44	2.98	No	Yes	0	5	6
31	R:R:V44	R:R:V48	1.6	Yes	No	0	6	6
32	R:R:V44	R:R:V87	6.41	Yes	Yes	1	6	7
33	R:R:P88	R:R:V44	1.77	No	Yes	1	8	6
34	R:R:A46	R:R:F49	4.16	No	No	0	5	4
35	R:R:I47	R:R:N51	4.25	Yes	Yes	12	8	9
36	R:R:D79	R:R:I47	2.8	Yes	Yes	12	9	8
37	R:R:G83	R:R:I47	1.76	Yes	Yes	0	7	8
38	R:R:G320	R:R:I47	5.29	No	Yes	0	7	8
39	R:R:G83	R:R:V48	1.84	Yes	No	0	7	6
40	R:R:L84	R:R:V48	2.98	No	No	0	5	6
41	R:R:F49	R:R:G50	3.01	No	No	0	4	8
42	R:R:G50	R:R:L53	1.71	No	Yes	0	8	6
43	R:R:D79	R:R:N51	13.46	Yes	Yes	12	9	9
44	R:R:L80	R:R:N51	6.87	No	Yes	0	7	9
45	R:R:N51	R:R:P323	3.26	Yes	Yes	0	9	9
46	R:R:T56	R:R:V52	1.59	No	No	0	5	3
47	R:R:A57	R:R:L53	1.58	No	Yes	13	8	6
48	R:R:F336	R:R:L53	6.09	No	Yes	0	7	6
49	R:R:L339	R:R:L53	2.77	No	Yes	13	6	6
50	R:R:A76	R:R:V54	1.7	No	No	0	9	9
51	R:R:P323	R:R:V54	1.77	Yes	No	0	9	9
52	R:R:C327	R:R:V54	3.42	No	No	0	7	9
53	R:R:I55	R:R:T73	3.04	Yes	No	0	7	6
54	R:R:A76	R:R:I55	1.62	No	Yes	0	9	7
55	R:R:I55	R:R:L80	2.85	Yes	No	0	7	7
56	R:R:A57	R:R:F332	2.77	No	Yes	0	8	9
57	R:R:A57	R:R:L339	1.58	No	No	13	8	6
58	R:R:I58	R:R:L64	4.28	Yes	Yes	6	7	8
59	R:R:I58	R:R:N69	2.83	Yes	No	6	7	9
60	R:R:I58	R:R:T73	7.6	Yes	No	0	7	6
61	R:R:K60	R:R:L339	2.82	No	No	0	5	6
62	R:R:F61	R:R:R63	3.21	No	No	0	6	6
63	R:R:F61	R:R:L64	2.44	No	Yes	0	6	8
64	R:R:E338	R:R:F61	5.83	No	No	0	4	6
65	R:R:E62	R:R:Q65	5.1	No	No	0	6	8
66	R:R:L64	R:R:N69	2.75	Yes	No	6	8	9
67	R:R:A335	R:R:L64	1.58	No	Yes	6	7	8
68	R:R:T66	R:R:V67	1.59	No	No	0	7	6
69	R:R:T66	R:R:T68	3.14	No	No	0	7	8
70	R:R:N69	R:R:T66	11.7	No	No	0	9	7
71	R:R:V67	R:R:Y141	6.31	No	Yes	0	6	7
72	R:R:A150	R:R:V67	1.7	No	No	0	7	6
73	R:R:F71	R:R:T68	2.59	Yes	No	1	8	8
74	R:R:D130	R:R:T68	2.89	Yes	No	1	8	8
75	R:R:K147	R:R:Y70	11.94	No	No	0	1	4
76	R:R:F71	R:R:V126	3.93	Yes	No	0	8	7
77	R:R:F71	R:R:I127	2.51	Yes	Yes	1	8	9
78	R:R:D130	R:R:F71	8.36	Yes	Yes	1	8	8
79	R:R:A150	R:R:F71	4.16	No	Yes	0	7	8
80	R:R:F71	R:R:I154	6.28	Yes	No	1	8	8
81	R:R:I127	R:R:I72	2.94	Yes	No	1	9	8
82	R:R:I72	R:R:Y326	3.63	No	Yes	1	8	9
83	R:R:S74	R:R:T123	4.8	No	Yes	1	9	8
84	R:R:I154	R:R:S74	9.29	No	No	1	8	9
85	R:R:S74	R:R:W158	4.94	No	Yes	1	9	9
86	R:R:L75	R:R:S120	3	Yes	No	0	9	9
87	R:R:L75	R:R:T123	4.42	Yes	Yes	1	9	8
88	R:R:L124	R:R:L75	4.15	No	Yes	0	8	9
89	R:R:I127	R:R:L75	2.85	Yes	Yes	1	9	9
90	R:R:L75	R:R:N322	10.98	Yes	No	0	9	9
91	R:R:C77	R:R:V81	1.71	No	No	0	6	7
92	R:R:C77	R:R:W158	2.61	No	Yes	0	6	9
93	R:R:A119	R:R:A78	1.79	No	No	1	7	8
94	R:R:A78	R:R:W158	3.89	No	Yes	1	8	9
95	R:R:D79	R:R:S319	11.78	Yes	Yes	0	9	9
96	R:R:D79	R:R:N322	9.42	Yes	No	0	9	9
97	R:R:L80	R:R:L84	2.77	No	No	0	7	5
98	R:R:I112	R:R:V81	3.07	Yes	No	1	4	7
99	R:R:C116	R:R:V81	3.42	No	No	1	7	7
100	R:R:G83	R:R:M82	1.75	Yes	Yes	0	7	7
101	R:R:M82	R:R:V86	7.61	Yes	Yes	1	7	7
102	R:R:C116	R:R:M82	6.48	No	Yes	1	7	7
103	R:R:M82	R:R:Y316	3.59	Yes	Yes	1	7	6
104	R:R:M82	R:R:S319	3.07	Yes	Yes	0	7	9
105	R:R:G83	R:R:V87	1.84	Yes	Yes	0	7	7
106	R:R:A85	R:R:I112	1.62	No	Yes	0	4	4
107	R:R:V86	R:R:W109	7.36	Yes	Yes	1	7	5
108	R:R:I112	R:R:V86	4.61	Yes	Yes	1	4	7
109	R:R:D113	R:R:V86	16.07	Yes	Yes	1	7	7
110	R:R:V86	R:R:Y316	3.79	Yes	Yes	1	7	6
111	R:R:P88	R:R:V87	3.53	No	Yes	1	8	7
112	R:R:V87	R:R:W313	3.68	Yes	Yes	1	7	5
113	R:R:F89	R:R:W99	4.01	No	Yes	1	5	7
114	R:R:F101	R:R:F89	5.36	No	No	1	5	5
115	R:R:F89	R:R:W109	7.02	No	Yes	1	5	5
116	R:R:G90	R:R:H93	1.59	No	No	0	7	4
117	R:R:G90	R:R:W109	4.22	No	Yes	0	7	5
118	R:R:H93	R:R:K97	5.24	No	No	0	4	4
119	R:R:H93	R:R:W99	4.23	No	Yes	0	4	7
120	R:R:I309	R:R:I94	5.89	No	No	1	3	5
121	R:R:I94	R:R:W313	2.35	No	Yes	1	5	5
122	R:R:M96	R:R:M98	7.22	No	No	0	4	5
123	R:R:F101	R:R:W99	12.03	No	Yes	1	5	7
124	R:R:C106	R:R:W99	3.92	No	Yes	1	9	7
125	R:R:W109	R:R:W99	13.12	Yes	Yes	1	5	7
126	R:R:C191	R:R:W99	5.22	Yes	Yes	1	9	7
127	R:R:E188	R:R:N103	2.63	No	No	0	3	2
128	R:R:F104	R:R:W105	8.02	No	No	0	1	5
129	R:R:C106	R:R:C191	7.28	No	Yes	1	9	9
130	R:R:E107	R:R:H172	9.85	No	No	1	5	4
131	R:R:E107	R:R:Y174	10.1	No	Yes	1	5	5
132	R:R:E107	R:R:Y185	2.24	No	Yes	1	5	1
133	R:R:F108	R:R:F166	3.22	No	Yes	1	5	4
134	R:R:F108	R:R:Q170	4.68	No	No	1	5	4
135	R:R:T110	R:R:W109	2.43	Yes	Yes	1	4	5
136	R:R:D113	R:R:W109	7.82	Yes	Yes	1	7	5
137	R:R:C191	R:R:W109	2.61	Yes	Yes	1	9	5
138	R:R:T110	R:R:V114	1.59	Yes	Yes	1	4	5
139	R:R:I169	R:R:T110	6.08	Yes	Yes	1	5	4
140	R:R:C191	R:R:T110	1.69	Yes	Yes	1	9	4
141	R:R:F193	R:R:T110	3.89	Yes	Yes	1	4	4
142	R:R:S111	R:R:S165	1.63	Yes	Yes	1	6	7
143	R:R:F166	R:R:S111	5.28	Yes	Yes	1	4	6
144	R:R:I169	R:R:S111	7.74	Yes	Yes	1	5	6
145	R:R:Q170	R:R:S111	10.11	No	Yes	1	4	6
146	R:R:C116	R:R:I112	3.27	No	Yes	1	7	4
147	R:R:F166	R:R:I112	2.51	Yes	Yes	1	4	4
148	R:R:D113	R:R:Y316	10.34	Yes	Yes	1	7	6
149	R:R:T118	R:R:V114	1.59	Yes	Yes	1	6	5
150	R:R:S165	R:R:V114	4.85	Yes	Yes	1	7	5
151	R:R:V114	R:R:Y199	3.79	Yes	Yes	1	5	6
152	R:R:S203	R:R:V114	1.62	Yes	Yes	1	5	5
153	R:R:L115	R:R:W158	3.42	Yes	Yes	1	5	9
154	R:R:G162	R:R:L115	3.42	No	Yes	0	4	5
155	R:R:L115	R:R:S165	9.01	Yes	Yes	1	5	7
156	R:R:F166	R:R:L115	7.31	Yes	Yes	1	4	5
157	R:R:T118	R:R:V117	1.59	Yes	No	1	6	6
158	R:R:V117	R:R:W286	4.9	No	Yes	1	6	8
159	R:R:E122	R:R:T118	4.23	Yes	Yes	1	5	6
160	R:R:S161	R:R:T118	6.4	Yes	Yes	1	8	6
161	R:R:S207	R:R:T118	9.59	Yes	Yes	1	5	6
162	R:R:A119	R:R:W158	2.59	No	Yes	1	7	9
163	R:R:A119	R:R:S161	3.42	No	Yes	1	7	8
164	R:R:S120	R:R:S319	3.26	No	Yes	0	9	9
165	R:R:I121	R:R:S207	3.1	Yes	Yes	1	7	5
166	R:R:I121	R:R:P211	3.39	Yes	No	0	7	8
167	R:R:F282	R:R:I121	5.02	Yes	Yes	1	9	7
168	R:R:I121	R:R:W286	7.05	Yes	Yes	1	7	8
169	R:R:E122	R:R:V157	4.28	Yes	No	0	5	7
170	R:R:E122	R:R:V160	5.7	Yes	No	0	5	4
171	R:R:E122	R:R:S161	4.31	Yes	Yes	1	5	8
172	R:R:I127	R:R:T123	3.04	Yes	Yes	1	9	8
173	R:R:T123	R:R:V157	1.59	Yes	No	0	8	7
174	R:R:L124	R:R:Y326	4.69	No	Yes	0	8	9
175	R:R:C125	R:R:P211	3.77	No	No	0	7	8
176	R:R:C125	R:R:I214	4.91	No	No	0	7	6
177	R:R:C125	R:R:M215	3.24	No	Yes	0	7	8
178	R:R:I153	R:R:V126	3.07	No	No	0	6	7
179	R:R:V126	R:R:V157	1.6	No	No	0	7	7
180	R:R:I127	R:R:R131	3.76	Yes	No	1	9	9
181	R:R:I127	R:R:Y326	6.04	Yes	Yes	1	9	9
182	R:R:A128	R:R:M215	4.83	No	Yes	1	8	8
183	R:R:A128	R:R:V218	3.39	No	Yes	1	8	6
184	R:R:A128	R:R:Y219	5.34	No	Yes	1	8	9
185	R:R:F133	R:R:V129	2.62	No	No	0	5	6
186	R:R:V129	R:R:V218	3.21	No	Yes	0	6	6
187	R:R:D130	R:R:Y141	8.05	Yes	Yes	1	8	7
188	R:R:D130	R:R:L145	4.07	Yes	No	1	8	7
189	R:R:R131	R:R:Y326	5.14	No	Yes	1	9	9
190	R:R:F133	R:R:Y132	6.19	No	Yes	0	5	8
191	R:R:T136	R:R:Y132	16.23	No	Yes	0	7	8
192	R:R:V218	R:R:Y132	7.57	Yes	Yes	1	6	8
193	R:R:R221	R:R:Y132	5.14	No	Yes	0	5	8
194	R:R:V222	R:R:Y132	2.52	Yes	Yes	1	8	8
195	R:R:A134	R:R:Y141	8.01	No	Yes	0	8	7
196	R:R:E225	R:R:I135	5.47	No	No	0	5	9
197	R:R:S137	R:R:T136	3.2	No	No	0	6	7
198	R:R:P138	R:R:S137	1.78	No	No	0	8	6
199	R:R:Q142	R:R:Y141	2.25	No	Yes	0	4	7
200	R:R:L145	R:R:Y141	5.86	No	Yes	1	7	7
201	R:R:K149	R:R:L144	2.82	Yes	No	0	5	4
202	R:R:K149	R:R:L145	4.23	Yes	No	0	5	7
203	R:R:I153	R:R:K149	10.18	No	Yes	0	6	5
204	R:R:I154	R:R:W158	2.35	No	Yes	1	8	9
205	R:R:M156	R:R:V160	3.04	No	No	0	4	4
206	R:R:G162	R:R:S161	1.86	No	Yes	0	4	8
207	R:R:L163	R:R:L167	5.54	No	No	0	4	5
208	R:R:P168	R:R:T164	1.75	No	No	0	5	5
209	R:R:S203	R:R:T164	1.6	Yes	No	0	5	5
210	R:R:T164	R:R:V206	1.59	No	No	0	5	4
211	R:R:F166	R:R:S165	6.61	Yes	Yes	1	4	7
212	R:R:F166	R:R:Q170	14.05	Yes	No	1	4	4
213	R:R:L167	R:R:P168	3.28	No	No	0	5	5
214	R:R:P168	R:R:Y199	4.17	No	Yes	0	5	6
215	R:R:I169	R:R:Y174	13.3	Yes	Yes	1	5	5
216	R:R:I169	R:R:Y199	7.25	Yes	Yes	1	5	6
217	R:R:M171	R:R:W173	19.78	No	No	0	4	4
218	R:R:H172	R:R:Y174	2.18	No	Yes	1	4	5
219	R:R:Y174	R:R:Y185	7.94	Yes	Yes	1	5	1
220	R:R:T195	R:R:Y174	3.75	Yes	Yes	1	3	5
221	R:R:Y174	R:R:Y199	4.96	Yes	Yes	1	5	6
222	R:R:N196	R:R:R175	6.03	No	No	0	4	2
223	R:R:A181	R:R:Y185	2.67	No	Yes	1	4	1
224	R:R:A181	R:R:F194	6.93	No	Yes	1	4	1
225	R:R:C184	R:R:C190	5.46	No	No	0	1	3
226	R:R:F194	R:R:Y185	2.06	Yes	Yes	1	1	1
227	R:R:N187	R:R:T189	2.92	No	No	0	4	4
228	R:R:C190	R:R:T189	1.69	No	No	0	3	4
229	R:R:D192	R:R:F194	15.52	No	Yes	1	3	1
230	R:R:D192	R:R:K305	2.77	No	No	1	3	2
231	R:R:F193	R:R:T195	9.08	Yes	Yes	1	4	3
232	R:R:F193	R:R:Y308	4.13	Yes	Yes	1	4	5
233	R:R:F194	R:R:K305	3.72	Yes	No	1	1	2
234	R:R:T195	R:R:Y199	7.49	Yes	Yes	1	3	6
235	R:R:A200	R:R:T195	3.36	No	Yes	0	5	3
236	R:R:N196	R:R:Y199	3.49	No	Yes	0	4	6
237	R:R:Q197	R:R:V297	2.87	No	No	0	2	5
238	R:R:S203	R:R:Y199	11.45	Yes	Yes	1	5	6
239	R:R:A200	R:R:V297	5.09	No	No	0	5	5
240	R:R:F290	R:R:S204	2.64	Yes	No	0	7	5
241	R:R:F290	R:R:S207	2.64	Yes	Yes	1	7	5
242	R:R:F208	R:R:Y209	5.16	Yes	No	1	8	5
243	R:R:F208	R:R:L212	4.87	Yes	No	0	8	7
244	R:R:F208	R:R:F282	7.5	Yes	Yes	1	8	9
245	R:R:F208	R:R:W286	3.01	Yes	Yes	1	8	8
246	R:R:F208	R:R:L287	7.31	Yes	No	0	8	6
247	R:R:F208	R:R:F290	21.43	Yes	Yes	1	8	7
248	R:R:I291	R:R:Y209	3.63	No	No	1	6	5
249	R:R:I294	R:R:Y209	4.84	No	No	1	6	5
250	R:R:P211	R:R:V210	3.53	No	No	0	8	5
251	R:R:I214	R:R:V210	3.07	No	No	0	6	5
252	R:R:L212	R:R:V216	2.98	No	No	0	7	5
253	R:R:M215	R:R:M279	4.33	Yes	No	1	8	8
254	R:R:F282	R:R:M215	4.98	Yes	Yes	1	9	8
255	R:R:F217	R:R:R221	9.62	No	No	0	4	5
256	R:R:V218	R:R:Y219	3.79	Yes	Yes	1	6	9
257	R:R:V218	R:R:V222	1.6	Yes	Yes	1	6	8
258	R:R:V222	R:R:Y219	3.79	Yes	Yes	1	8	9
259	R:R:I278	R:R:Y219	4.84	No	Yes	0	8	9
260	R:R:M279	R:R:Y219	8.38	No	Yes	1	8	9
261	R:R:Q224	R:R:R221	2.34	No	No	0	3	5
262	R:R:F223	R:R:K227	9.93	No	No	0	6	6
263	R:R:A271	R:R:F223	2.77	No	No	0	8	6
264	R:R:F223	R:R:L275	3.65	No	No	0	6	8
265	R:R:K227	R:R:Q224	8.14	No	No	14	6	3
266	R:R:Q224	R:R:R228	4.67	No	No	14	3	4
267	R:R:A226	R:R:A271	1.79	No	No	0	8	8
268	R:R:K227	R:R:R228	2.48	No	No	14	6	4
269	R:R:D234	R:R:G238	1.68	No	No	0	4	4
270	R:R:H269	V:V:F190	4.53	No	No	0	5	9
271	R:R:K270	R:R:R273	3.71	No	Yes	0	7	7
272	R:R:K270	R:R:T274	4.5	No	No	0	7	8
273	R:R:R273	V:V:F190	14.97	Yes	No	0	7	9
274	R:R:R273	V:V:L191	6.07	Yes	No	1	7	5
275	R:R:R273	W:W:?1	3.47	Yes	Yes	1	7	0
276	R:R:I278	R:R:T274	3.04	No	No	0	8	8
277	R:R:R328	R:R:T274	3.88	No	No	0	7	8
278	R:R:S276	W:W:?1	7.86	No	Yes	0	6	0
279	R:R:T281	R:R:V277	1.59	Yes	No	1	6	7
280	R:R:I325	R:R:V277	3.07	Yes	No	1	8	7
281	R:R:V277	W:W:?1	4.96	No	Yes	1	7	0
282	R:R:I278	R:R:Y326	4.84	No	Yes	0	8	9
283	R:R:F282	R:R:M279	2.49	Yes	No	1	9	8
284	R:R:G280	R:R:T283	3.64	No	No	0	5	7
285	R:R:G280	W:W:?1	2.44	No	Yes	0	5	0
286	R:R:C285	R:R:T281	1.69	Yes	Yes	0	9	6
287	R:R:F321	R:R:T281	2.59	Yes	Yes	1	6	6
288	R:R:I325	R:R:T281	4.56	Yes	Yes	1	8	6
289	R:R:T281	W:W:?1	5.61	Yes	Yes	1	6	0
290	R:R:F282	R:R:T283	2.59	Yes	No	0	9	7
291	R:R:F282	R:R:W286	5.01	Yes	Yes	1	9	8
292	R:R:F282	R:R:N318	2.42	Yes	Yes	1	9	9
293	R:R:L287	R:R:T283	2.95	No	No	0	6	7
294	R:R:C285	R:R:L284	1.59	Yes	No	0	9	5
295	R:R:L284	W:W:?1	7.9	No	Yes	0	5	0
296	R:R:C285	R:R:G315	1.96	Yes	No	0	9	7
297	R:R:C285	R:R:V317	1.71	Yes	No	0	9	5
298	R:R:C285	R:R:N318	4.72	Yes	Yes	0	9	9
299	R:R:F289	R:R:W286	7.02	Yes	Yes	1	6	8
300	R:R:F290	R:R:W286	10.02	Yes	Yes	1	7	8
301	R:R:G315	R:R:W286	7.04	No	Yes	0	7	8
302	R:R:W286	R:R:Y316	2.89	Yes	Yes	1	8	6
303	R:R:N318	R:R:W286	12.43	Yes	Yes	1	9	8
304	R:R:L287	R:R:P288	3.28	No	No	0	6	9
305	R:R:L311	R:R:P288	1.64	Yes	No	0	5	9
306	R:R:I314	R:R:P288	1.69	No	No	0	7	9
307	R:R:F289	R:R:F290	4.29	Yes	Yes	1	6	7
308	R:R:F289	R:R:N293	13.29	Yes	Yes	1	6	5
309	R:R:F289	R:R:Y308	6.19	Yes	Yes	1	6	5
310	R:R:F289	R:R:L311	2.44	Yes	Yes	0	6	5
311	R:R:F289	R:R:N312	10.87	Yes	No	1	6	5
312	R:R:F290	R:R:N293	2.42	Yes	Yes	1	7	5
313	R:R:I291	R:R:I294	2.94	No	No	1	6	6
314	R:R:I303	R:R:V292	6.14	No	No	0	3	5
315	R:R:L311	R:R:V292	5.96	Yes	No	0	5	5
316	R:R:N293	R:R:Y308	3.49	Yes	Yes	1	5	5
317	R:R:L302	R:R:V295	5.96	No	No	0	1	4
318	R:R:H296	R:R:I303	3.98	No	No	0	3	3
319	R:R:I298	R:R:Q299	5.49	No	No	0	4	2
320	R:R:L302	R:R:Q299	2.66	No	No	0	1	2
321	R:R:D300	R:R:N301	5.39	No	No	0	1	2
322	R:R:I303	R:R:V307	6.14	No	No	0	3	4
323	R:R:E306	R:R:R304	17.45	No	No	0	2	4
324	R:R:R304	R:R:V307	3.92	No	No	0	4	4
325	R:R:L311	R:R:V307	2.98	Yes	No	0	5	4
326	R:R:I309	R:R:W313	2.35	No	Yes	1	3	5
327	R:R:N312	R:R:Y316	9.3	No	Yes	1	5	6
328	R:R:W313	R:R:Y316	9.65	Yes	Yes	1	5	6
329	R:R:G315	R:R:I314	1.76	No	No	0	7	7
330	R:R:F321	R:R:V317	7.87	Yes	No	0	6	5
331	R:R:N318	R:R:S319	4.47	Yes	Yes	0	9	9
332	R:R:G320	R:R:P323	2.03	No	Yes	0	7	9
333	R:R:F321	R:R:I325	2.51	Yes	Yes	1	6	8
334	R:R:F321	V:V:K195	3.72	Yes	Yes	1	6	7
335	R:R:F321	W:W:?1	12.17	Yes	Yes	1	6	0
336	R:R:N322	R:R:P323	8.15	No	Yes	0	9	9
337	R:R:L324	R:R:P323	1.64	No	Yes	0	6	9
338	R:R:L324	V:V:P196	3.28	No	No	0	6	6
339	R:R:L324	W:W:?1	2.63	No	Yes	0	6	0
340	R:R:I325	R:R:Y326	4.84	Yes	Yes	1	8	9
341	R:R:C327	R:R:F332	15.36	No	Yes	0	7	9
342	R:R:R328	V:V:R188	10.66	No	No	0	7	8
343	R:R:P330	R:R:S329	3.56	No	No	0	5	8
344	R:R:D331	R:R:S329	7.36	No	No	0	7	8
345	R:R:P330	R:R:R333	12.97	No	Yes	0	5	9
346	R:R:F332	R:R:R333	2.14	Yes	Yes	0	9	9
347	R:R:F332	R:R:F336	8.57	Yes	No	0	9	7
348	R:R:Q337	R:R:R333	4.67	No	Yes	7	4	9
349	R:R:R333	V:V:E185	4.65	Yes	Yes	7	9	5
350	R:R:R333	V:V:T187	6.47	Yes	No	7	9	5
351	R:R:A335	R:R:I334	1.62	No	No	6	7	4
352	R:R:E338	R:R:I334	2.73	No	No	6	4	4
353	R:R:A335	R:R:E338	3.02	No	No	6	7	4
354	R:R:Q337	V:V:E185	10.19	No	Yes	7	4	5
355	R:R:C341	R:R:L340	1.59	No	No	0	5	6
356	V:V:F9	V:V:R7	9.62	No	No	0	6	4
357	V:V:V8	V:V:Y21	11.36	No	Yes	4	7	8
358	V:V:L104	V:V:V8	4.47	Yes	No	4	9	7
359	V:V:F9	V:V:R25	2.14	No	Yes	0	6	9
360	V:V:K11	V:V:V164	6.07	No	Yes	0	9	8
361	V:V:A12	V:V:T19	1.68	No	No	0	5	7
362	V:V:P14	V:V:S13	3.56	No	No	0	6	8
363	V:V:L18	V:V:S13	3	No	No	0	6	8
364	V:V:S13	V:V:V164	8.08	No	Yes	0	8	8
365	V:V:K17	V:V:N15	4.2	Yes	No	15	5	8
366	V:V:N15	V:V:R161	15.67	No	No	0	8	7
367	V:V:N15	V:V:N162	2.72	No	No	15	8	8
368	V:V:G16	V:V:K17	1.74	No	Yes	0	5	5
369	V:V:D44	V:V:K17	12.44	No	Yes	0	8	5
370	V:V:K17	V:V:N162	2.8	Yes	No	15	5	8
371	V:V:L18	V:V:V43	5.96	No	Yes	0	6	6
372	V:V:C150	V:V:L18	4.76	No	No	0	5	6
373	V:V:L22	V:V:V20	2.98	Yes	Yes	2	8	6
374	V:V:V20	V:V:V41	4.81	Yes	No	0	6	5
375	V:V:F115	V:V:V20	2.62	Yes	Yes	2	9	6
376	V:V:V164	V:V:V20	3.21	Yes	Yes	0	8	6
377	V:V:G23	V:V:Y21	4.35	No	Yes	0	8	8
378	V:V:G39	V:V:Y21	5.79	No	Yes	0	8	8
379	V:V:V40	V:V:Y21	5.05	Yes	Yes	4	8	8
380	V:V:L100	V:V:Y21	3.52	No	Yes	0	5	8
381	V:V:L104	V:V:Y21	23.45	Yes	Yes	4	9	8
382	V:V:G23	V:V:L22	1.71	No	Yes	0	8	8
383	V:V:F115	V:V:L22	7.31	Yes	Yes	2	9	8
384	V:V:L166	V:V:L22	5.54	No	Yes	2	8	8
385	V:V:L166	V:V:R25	12.15	No	Yes	2	8	9
386	V:V:I168	V:V:R25	2.51	Yes	Yes	2	8	9
387	V:V:L293	V:V:R25	6.07	No	Yes	0	8	9
388	V:V:D26	V:V:R169	5.96	No	Yes	2	9	9
389	V:V:D26	V:V:V171	7.3	No	No	2	9	6
390	V:V:D26	V:V:Y173	5.75	No	Yes	2	9	4
391	V:V:D35	V:V:F27	5.97	No	No	0	6	8
392	V:V:F27	V:V:V37	9.18	No	Yes	2	8	8
393	V:V:F27	V:V:I168	6.28	No	Yes	2	8	8
394	V:V:H30	V:V:V28	8.3	No	No	0	6	8
395	V:V:V28	V:V:Y173	3.79	No	Yes	0	8	4
396	V:V:D29	V:V:K170	4.15	No	No	0	9	9
397	V:V:D29	V:V:Q172	11.75	No	Yes	0	9	9
398	V:V:I31	V:V:L305	2.85	No	No	0	5	5
399	V:V:E308	V:V:I31	2.73	Yes	No	0	3	5
400	V:V:D32	V:V:L33	4.07	No	No	0	4	3
401	V:V:D32	V:V:P121	8.05	No	No	0	4	4
402	V:V:D32	V:V:E308	2.6	No	Yes	0	4	3
403	V:V:K170	V:V:V34	3.04	No	No	0	9	7
404	V:V:D35	V:V:P36	6.44	No	No	0	6	5
405	V:V:K95	V:V:P36	3.35	Yes	No	16	3	5
406	V:V:P36	V:V:T116	1.75	No	No	16	5	4
407	V:V:L57	V:V:V37	4.47	Yes	Yes	2	7	8
408	V:V:F117	V:V:V37	5.24	Yes	Yes	2	8	8
409	V:V:I168	V:V:V37	3.07	Yes	Yes	2	8	8
410	V:V:D38	V:V:G39	6.71	No	No	0	7	8
411	V:V:D38	V:V:T98	14.45	No	No	0	7	8
412	V:V:F115	V:V:G39	4.52	Yes	No	0	9	8
413	V:V:Q101	V:V:V40	8.6	Yes	Yes	4	9	8
414	V:V:L104	V:V:V40	5.96	Yes	Yes	4	9	8
415	V:V:L108	V:V:V40	2.98	Yes	Yes	4	8	8
416	V:V:A112	V:V:V40	1.7	No	Yes	4	8	8
417	V:V:P114	V:V:V40	1.77	No	Yes	4	8	8
418	V:V:V41	V:V:V43	3.21	No	Yes	0	5	6
419	V:V:L108	V:V:L42	2.77	Yes	No	0	8	5
420	V:V:V43	V:V:Y47	2.52	Yes	Yes	8	6	5
421	V:V:V43	V:V:V53	4.81	Yes	No	8	6	7
422	V:V:F87	V:V:V43	6.55	Yes	Yes	8	4	6
423	V:V:D44	V:V:P45	1.61	No	No	0	8	4
424	V:V:D44	V:V:E46	10.39	No	No	0	8	3
425	V:V:L48	V:V:P45	1.64	No	No	0	4	4
426	V:V:H111	V:V:P45	13.73	No	No	0	6	4
427	V:V:K49	V:V:Y47	3.58	No	Yes	8	5	5
428	V:V:E50	V:V:Y47	2.24	No	Yes	8	4	5
429	V:V:C150	V:V:Y47	4.03	No	Yes	0	5	5
430	V:V:F87	V:V:L48	3.65	Yes	No	0	4	4
431	V:V:E50	V:V:K49	4.05	No	No	8	4	5
432	V:V:R52	V:V:Y54	13.38	No	Yes	0	6	4
433	V:V:P88	V:V:R52	5.76	No	No	0	9	6
434	V:V:F87	V:V:V53	6.55	Yes	No	8	4	7
435	V:V:C150	V:V:V53	10.25	No	No	0	5	7
436	V:V:N83	V:V:Y54	6.98	Yes	Yes	5	5	4
437	V:V:Q85	V:V:Y54	18.04	No	Yes	5	9	4
438	V:V:F149	V:V:Y54	11.35	Yes	Yes	5	5	4
439	V:V:V55	V:V:V84	1.6	Yes	No	2	8	3
440	V:V:S86	V:V:V55	1.62	No	Yes	2	6	8
441	V:V:F115	V:V:V55	3.93	Yes	Yes	2	9	8
442	V:V:F117	V:V:V55	7.87	Yes	Yes	2	8	8
443	V:V:A148	V:V:V55	3.39	No	Yes	0	6	8
444	V:V:T56	V:V:V81	1.59	No	No	0	7	4
445	V:V:N83	V:V:T56	4.39	Yes	No	5	5	7
446	V:V:F149	V:V:T56	2.59	Yes	No	5	5	7
447	V:V:C59	V:V:L57	1.59	Yes	Yes	2	8	7
448	V:V:F117	V:V:L57	9.74	Yes	Yes	2	8	7
449	V:V:L57	V:V:V146	2.98	Yes	No	0	7	6
450	V:V:T58	V:V:V81	6.35	No	No	0	7	4
451	V:V:E145	V:V:T58	9.88	Yes	No	0	7	7
452	V:V:C59	V:V:L79	1.59	Yes	Yes	2	8	8
453	V:V:C59	V:V:F80	4.19	Yes	No	0	8	4
454	V:V:C59	V:V:I119	1.64	Yes	No	0	8	5
455	V:V:C59	V:V:L123	9.52	Yes	Yes	2	8	6
456	V:V:C59	V:V:Y144	5.38	Yes	Yes	2	8	7
457	V:V:A60	V:V:R76	2.77	No	Yes	10	8	8
458	V:V:A60	V:V:D78	3.09	No	No	10	8	8
459	V:V:A60	V:V:E145	4.53	No	Yes	10	8	7
460	V:V:F61	V:V:K77	7.44	Yes	Yes	2	9	9
461	V:V:F61	V:V:V142	2.62	Yes	No	2	9	9
462	V:V:F61	V:V:L243	23.14	Yes	No	2	9	7
463	V:V:F61	V:V:I317	2.51	Yes	Yes	2	9	8
464	V:V:R62	V:V:R76	2.13	Yes	Yes	10	8	8
465	V:V:A139	V:V:R62	2.77	No	Yes	0	5	8
466	V:V:D143	V:V:R62	9.53	No	Yes	0	7	8
467	V:V:E145	V:V:R62	3.49	Yes	Yes	10	7	8
468	V:V:F75	V:V:Y63	8.25	No	No	0	9	9
469	V:V:F75	V:V:K138	2.48	No	No	0	9	8
470	V:V:D78	V:V:R76	7.15	No	Yes	10	8	8
471	V:V:E145	V:V:R76	4.65	Yes	Yes	10	7	8
472	V:V:K77	V:V:L79	7.05	Yes	Yes	2	9	8
473	V:V:K77	V:V:L243	14.1	Yes	No	2	9	7
474	V:V:F244	V:V:K77	7.44	No	Yes	0	8	9
475	V:V:L123	V:V:L79	6.92	Yes	Yes	2	6	8
476	V:V:L79	V:V:P124	1.64	Yes	Yes	2	8	9
477	V:V:L315	V:V:L79	2.77	No	Yes	2	5	8
478	V:V:A82	V:V:F80	2.77	No	No	0	4	4
479	V:V:F80	V:V:N122	8.46	No	No	0	4	5
480	V:V:N83	V:V:Q85	6.6	Yes	No	5	5	9
481	V:V:F149	V:V:N83	3.62	Yes	Yes	5	5	5
482	V:V:S86	V:V:V84	3.23	No	No	2	6	3
483	V:V:F117	V:V:V84	5.24	Yes	No	2	8	3
484	V:V:F87	V:V:P88	2.89	Yes	No	0	4	9
485	V:V:F87	V:V:Y113	3.09	Yes	No	0	4	3
486	V:V:P88	V:V:P89	1.95	No	No	0	9	3
487	V:V:P89	V:V:P91	1.95	No	No	0	3	3
488	V:V:A90	V:V:P91	1.87	No	No	17	1	3
489	V:V:A90	V:V:E92	4.53	No	No	17	1	3
490	V:V:E92	V:V:P91	3.14	No	No	17	3	3
491	V:V:K95	V:V:P96	5.02	Yes	No	0	3	3
492	V:V:K95	V:V:T116	15.02	Yes	No	16	3	4
493	V:V:L97	V:V:Q101	11.98	No	Yes	0	4	9
494	V:V:Q101	V:V:T98	4.25	Yes	No	0	9	8
495	V:V:E102	V:V:R99	2.33	No	No	0	6	4
496	V:V:P114	V:V:Q101	11.05	No	Yes	4	8	9
497	V:V:K107	V:V:R103	9.9	No	No	0	9	6
498	V:V:L104	V:V:L108	4.15	Yes	Yes	4	9	8
499	V:V:I105	V:V:K106	4.36	No	No	0	4	6
500	V:V:A112	V:V:L108	4.73	No	Yes	4	8	8
501	V:V:E110	V:V:H111	7.39	No	No	0	3	6
502	V:V:F115	V:V:F117	5.36	Yes	Yes	2	9	8
503	V:V:I119	V:V:P120	3.39	No	No	0	5	7
504	V:V:P120	V:V:P121	1.95	No	No	0	7	4
505	V:V:L123	V:V:N122	4.12	Yes	No	0	6	5
506	V:V:L315	V:V:N122	4.12	No	No	0	5	5
507	V:V:L123	V:V:P124	6.57	Yes	Yes	2	6	9
508	V:V:L123	V:V:V142	5.96	Yes	No	2	6	9
509	V:V:L123	V:V:Y144	14.07	Yes	Yes	2	6	7
510	V:V:I314	V:V:P124	1.69	Yes	Yes	2	5	9
511	V:V:L315	V:V:P124	1.64	No	Yes	2	5	9
512	V:V:G316	V:V:P124	4.06	No	Yes	2	8	9
513	V:V:C125	V:V:V127	1.71	No	Yes	2	7	8
514	V:V:C125	V:V:Q172	6.1	No	Yes	2	7	9
515	V:V:C125	V:V:T304	3.38	No	No	2	7	9
516	V:V:R169	V:V:S126	6.59	Yes	No	2	9	9
517	V:V:G291	V:V:S126	1.86	Yes	No	2	9	9
518	V:V:A288	V:V:V127	1.7	No	Yes	2	9	8
519	V:V:I317	V:V:V127	3.07	Yes	Yes	2	8	8
520	V:V:V127	V:V:V319	3.21	Yes	Yes	2	8	8
521	V:V:G291	V:V:T128	1.82	Yes	No	0	9	6
522	V:V:K292	V:V:T128	9.01	Yes	No	0	6	6
523	V:V:I241	V:V:L129	4.28	Yes	No	0	8	8
524	V:V:G286	V:V:L129	1.71	No	No	0	9	8
525	V:V:P131	V:V:Q130	3.16	Yes	No	0	8	9
526	V:V:L287	V:V:Q130	6.65	Yes	No	0	7	9
527	V:V:L289	V:V:Q130	6.65	No	No	0	9	9
528	V:V:G132	V:V:P131	2.03	Yes	Yes	0	6	8
529	V:V:P131	V:V:T136	8.74	Yes	No	0	8	4
530	V:V:C140	V:V:P131	5.65	No	Yes	0	9	8
531	V:V:K292	V:V:P131	3.35	Yes	Yes	0	6	8
532	V:V:G132	V:V:P133	4.06	Yes	No	0	6	4
533	V:V:D135	V:V:G132	3.35	No	Yes	18	8	6
534	V:V:G132	V:V:R285	6	Yes	No	18	6	7
535	V:V:E283	V:V:P133	3.14	No	No	0	5	4
536	V:V:D135	V:V:R285	3.57	No	No	18	8	7
537	V:V:G137	V:V:T136	1.82	No	No	0	8	4
538	V:V:G137	V:V:K138	1.74	No	No	0	8	8
539	V:V:I317	V:V:V142	4.61	Yes	No	2	8	9
540	V:V:I168	V:V:Y144	3.63	Yes	Yes	2	8	7
541	V:V:K170	V:V:Y144	7.17	No	Yes	0	9	7
542	V:V:E145	V:V:R165	4.65	Yes	No	0	7	5
543	V:V:I168	V:V:V146	4.61	Yes	No	0	8	6
544	V:V:K147	V:V:S163	6.12	No	No	0	7	8
545	V:V:K147	V:V:R165	2.48	No	No	0	7	5
546	V:V:A148	V:V:V164	1.7	No	Yes	0	6	8
547	V:V:A151	V:V:F149	2.77	No	Yes	5	6	5
548	V:V:F149	V:V:I158	11.3	Yes	No	5	5	5
549	V:V:A151	V:V:E156	6.03	No	No	0	6	6
550	V:V:A151	V:V:I158	3.25	No	No	5	6	5
551	V:V:E152	V:V:E156	6.34	No	No	0	4	6
552	V:V:E156	V:V:N153	5.26	No	No	0	6	4
553	V:V:E155	V:V:L154	6.63	No	No	0	4	3
554	V:V:H159	V:V:K157	5.24	No	No	0	5	6
555	V:V:R165	V:V:V167	10.46	No	No	0	5	5
556	V:V:I168	V:V:L166	2.85	Yes	No	2	8	8
557	V:V:R169	V:V:V171	3.92	Yes	No	2	9	6
558	V:V:D290	V:V:R169	4.76	No	Yes	2	9	9
559	V:V:G291	V:V:R169	3	Yes	Yes	2	9	9
560	V:V:L293	V:V:R169	4.86	No	Yes	0	8	9
561	V:V:V171	V:V:Y173	6.31	No	Yes	2	6	4
562	V:V:Q172	V:V:T304	2.83	Yes	No	2	9	9
563	V:V:L305	V:V:Q172	6.65	No	Yes	0	5	9
564	V:V:K355	V:V:Y173	8.36	No	Yes	0	6	4
565	V:V:A174	V:V:P175	1.87	No	No	0	9	9
566	V:V:A174	V:V:I207	3.25	No	Yes	11	9	5
567	V:V:A174	V:V:M352	1.61	No	Yes	11	9	8
568	V:V:P178	V:V:R177	2.88	No	No	0	4	3
569	V:V:I207	V:V:P178	1.69	Yes	No	0	5	4
570	V:V:G179	V:V:P180	4.06	No	No	2	6	4
571	V:V:E206	V:V:G179	1.64	No	No	2	7	6
572	V:V:E206	V:V:P180	4.72	No	No	2	7	4
573	V:V:P182	V:V:Q181	3.16	Yes	No	0	9	7
574	V:V:K205	V:V:Q181	2.71	No	No	0	8	7
575	V:V:L203	V:V:P182	6.57	Yes	Yes	2	8	9
576	V:V:L347	V:V:P182	4.93	Yes	Yes	2	6	9
577	V:V:S202	V:V:T183	3.2	No	No	0	7	4
578	V:V:A184	V:V:V345	5.09	No	Yes	0	5	7
579	V:V:A184	V:V:L347	1.58	No	Yes	0	5	6
580	V:V:E185	V:V:T187	2.82	Yes	No	7	5	5
581	V:V:E185	V:V:H198	8.62	Yes	No	7	5	6
582	V:V:E185	V:V:E200	5.07	Yes	No	7	5	7
583	V:V:T186	V:V:V343	6.35	No	Yes	0	7	7
584	V:V:T186	V:V:V345	3.17	No	Yes	0	7	7
585	V:V:R188	V:V:S193	2.64	No	No	0	8	9
586	V:V:R188	W:W:?1	2.89	No	Yes	0	8	0
587	V:V:Q189	V:V:S193	2.89	No	No	0	6	9
588	V:V:G336	V:V:L191	1.71	No	No	0	5	5
589	V:V:L191	W:W:?1	7.9	No	Yes	1	5	0
590	V:V:L197	V:V:M192	2.83	No	Yes	0	7	7
591	V:V:M192	V:V:V329	10.65	Yes	No	19	7	6
592	V:V:M192	V:V:S341	6.13	Yes	No	19	7	8
593	V:V:M192	V:V:V343	3.04	Yes	Yes	0	7	7
594	V:V:S193	V:V:V343	3.23	No	Yes	0	9	7
595	V:V:D194	W:W:?1	43.92	No	Yes	0	6	0
596	V:V:K195	V:V:P196	6.69	Yes	No	0	7	6
597	V:V:K195	V:V:T224	3	Yes	No	0	7	9
598	V:V:K195	V:V:N225	2.8	Yes	No	1	7	5
599	V:V:K195	W:W:?1	6.71	Yes	Yes	1	7	0
600	V:V:N223	V:V:P196	14.66	No	No	0	6	6
601	V:V:L197	V:V:T224	8.84	No	No	0	7	9
602	V:V:E200	V:V:H198	7.39	No	No	7	7	6
603	V:V:H198	V:V:T221	8.21	No	No	0	6	5
604	V:V:L199	V:V:V220	4.47	No	No	0	6	6
605	V:V:E200	V:V:H219	2.46	No	No	0	7	5
606	V:V:A201	V:V:V325	1.7	No	No	3	7	8
607	V:V:A201	V:V:V345	1.7	No	Yes	3	7	7
608	V:V:N217	V:V:S202	2.98	No	No	0	6	7
609	V:V:L203	V:V:Y208	3.52	Yes	Yes	2	8	6
610	V:V:I214	V:V:L203	7.14	Yes	Yes	2	8	8
611	V:V:L203	V:V:V216	2.98	Yes	No	0	8	7
612	V:V:L203	V:V:L347	2.77	Yes	Yes	2	8	6
613	V:V:D204	V:V:K205	4.15	No	No	2	6	8
614	V:V:D204	V:V:Y208	3.45	No	Yes	2	6	6
615	V:V:D204	V:V:S215	8.83	No	No	0	6	4
616	V:V:K205	V:V:Y208	7.17	No	Yes	2	8	6
617	V:V:I207	V:V:Y209	6.04	Yes	No	0	5	6
618	V:V:I207	V:V:T350	3.04	Yes	No	11	5	4
619	V:V:I207	V:V:M352	2.92	Yes	Yes	11	5	8
620	V:V:E212	V:V:Y208	3.37	No	Yes	0	8	6
621	V:V:I214	V:V:Y208	16.92	Yes	Yes	2	8	6
622	V:V:F349	V:V:Y208	3.09	Yes	Yes	2	7	6
623	V:V:P354	V:V:Y209	22.25	No	No	0	8	6
624	V:V:H210	V:V:N299	7.65	Yes	Yes	2	9	8
625	V:V:H210	V:V:L300	2.57	Yes	No	0	9	9
626	V:V:H210	V:V:S302	2.79	Yes	No	0	9	9
627	V:V:H210	V:V:L351	16.71	Yes	No	2	9	8
628	V:V:H210	V:V:H353	15.53	Yes	No	2	9	8
629	V:V:F277	V:V:G211	4.52	No	No	0	3	8
630	V:V:E212	V:V:P213	3.14	No	No	0	8	4
631	V:V:P213	V:V:T275	6.99	No	No	0	4	4
632	V:V:I214	V:V:P276	1.69	Yes	No	0	8	9
633	V:V:F349	V:V:I214	6.28	Yes	Yes	2	7	8
634	V:V:S215	V:V:V271	1.62	No	No	0	4	5
635	V:V:S215	V:V:T273	3.2	No	No	0	4	3
636	V:V:V218	V:V:V220	3.21	No	No	0	7	6
637	V:V:C269	V:V:H219	4.42	No	No	0	5	5
638	V:V:T221	V:V:T267	4.71	No	No	0	5	6
639	V:V:N222	V:V:T224	4.39	Yes	No	0	9	9
640	V:V:N222	V:V:V228	2.96	Yes	No	3	9	8
641	V:V:N222	V:V:V262	5.91	Yes	No	3	9	7
642	V:V:N222	V:V:P264	3.26	Yes	No	0	9	5
643	V:V:K226	V:V:N225	5.6	No	No	1	8	5
644	V:V:N225	W:W:?1	1.96	No	Yes	1	5	0
645	V:V:K226	V:V:R331	17.33	No	No	0	8	5
646	V:V:K226	W:W:?1	2.68	No	Yes	1	8	0
647	V:V:P264	V:V:T227	3.5	No	No	0	5	5
648	V:V:V228	V:V:V262	3.21	No	No	3	8	7
649	V:V:L327	V:V:V228	8.94	No	No	0	7	8
650	V:V:K229	V:V:K230	8.62	Yes	Yes	3	8	5
651	V:V:D260	V:V:K229	15.21	No	Yes	3	6	8
652	V:V:K229	V:V:V328	4.55	Yes	No	3	8	4
653	V:V:K229	V:V:S330	12.24	Yes	No	3	8	6
654	V:V:K230	V:V:K232	8.62	Yes	No	0	5	6
655	V:V:A258	V:V:K230	1.61	No	Yes	3	5	5
656	V:V:D260	V:V:K230	11.06	No	Yes	3	6	5
657	V:V:K230	V:V:V328	6.07	Yes	No	3	5	4
658	V:V:I231	V:V:I233	4.42	No	Yes	3	6	5
659	V:V:A258	V:V:I231	1.62	No	No	3	5	6
660	V:V:I231	V:V:Y272	6.04	No	Yes	3	6	4
661	V:V:E257	V:V:K232	6.75	No	No	0	6	6
662	V:V:I233	V:V:Y272	2.42	Yes	Yes	3	5	4
663	V:V:I233	V:V:L274	7.14	Yes	No	0	5	5
664	V:V:I233	V:V:V325	4.61	Yes	No	3	5	8
665	V:V:K324	V:V:S234	4.59	No	No	0	6	5
666	V:V:V235	V:V:V253	4.81	No	No	0	8	9
667	V:V:V235	V:V:V323	3.21	No	No	2	8	7
668	V:V:F349	V:V:V235	2.62	Yes	No	2	7	8
669	V:V:R236	V:V:Y238	3.09	No	Yes	9	5	4
670	V:V:K250	V:V:R236	22.28	No	No	9	5	5
671	V:V:P252	V:V:R236	4.32	No	No	0	4	5
672	V:V:A239	V:V:Q237	4.55	No	Yes	0	8	9
673	V:V:C251	V:V:Q237	7.63	No	Yes	2	6	9
674	V:V:Q237	V:V:V253	2.87	Yes	No	0	9	9
675	V:V:L287	V:V:Q237	5.32	Yes	Yes	2	7	9
676	V:V:Q237	V:V:Y321	12.4	Yes	Yes	2	9	9
677	V:V:Q248	V:V:Y238	3.38	No	Yes	0	6	4
678	V:V:K250	V:V:Y238	20.3	No	Yes	9	5	4
679	V:V:S320	V:V:Y238	3.82	No	Yes	9	8	4
680	V:V:K322	V:V:Y238	11.94	Yes	Yes	9	5	4
681	V:V:E346	V:V:Y238	13.47	No	Yes	9	8	4
682	V:V:A239	V:V:I241	1.62	No	Yes	0	8	8
683	V:V:D240	V:V:I318	4.2	No	Yes	0	6	5
684	V:V:I241	V:V:Y249	7.25	Yes	No	0	8	7
685	V:V:I241	V:V:I317	7.36	Yes	Yes	0	8	8
686	V:V:A247	V:V:C242	3.61	No	No	0	8	6
687	V:V:G316	V:V:L243	1.71	No	No	2	8	7
688	V:V:C251	V:V:P252	1.88	No	No	0	6	4
689	V:V:C251	V:V:L287	3.17	No	Yes	2	6	7
690	V:V:P276	V:V:V253	1.77	No	No	0	9	9
691	V:V:E256	V:V:L274	11.93	No	No	0	4	5
692	V:V:A258	V:V:Y272	2.67	No	Yes	3	5	4
693	V:V:D259	V:V:T261	5.78	No	No	0	3	5
694	V:V:D259	V:V:F268	4.78	No	No	3	3	5
695	V:V:D259	V:V:K270	6.91	No	Yes	3	3	8
696	V:V:F268	V:V:V262	5.24	No	No	3	5	7
697	V:V:A263	V:V:P264	1.87	No	No	0	4	5
698	V:V:C269	V:V:T267	1.69	No	No	0	5	6
699	V:V:F268	V:V:K270	17.37	No	Yes	3	5	8
700	V:V:K270	V:V:Y272	10.75	Yes	Yes	3	8	4
701	V:V:P276	V:V:T275	3.5	No	No	0	9	4
702	V:V:L278	V:V:L289	2.77	No	No	0	8	9
703	V:V:N280	V:V:N281	9.54	No	No	0	4	9
704	V:V:K284	V:V:N281	5.6	No	No	0	8	9
705	V:V:E283	V:V:R282	2.33	No	No	0	5	6
706	V:V:D297	V:V:R282	11.91	No	No	0	8	6
707	V:V:L287	V:V:L300	4.15	Yes	No	0	7	9
708	V:V:A288	V:V:A301	1.79	No	No	2	9	9
709	V:V:A288	V:V:V319	1.7	No	Yes	2	9	8
710	V:V:L289	V:V:T298	4.42	No	No	0	9	8
711	V:V:D290	V:V:G291	1.68	No	Yes	2	9	9
712	V:V:D290	V:V:N299	6.73	No	Yes	2	9	8
713	V:V:E296	V:V:K292	2.7	No	Yes	0	7	6
714	V:V:K292	V:V:T298	6.01	Yes	No	0	6	8
715	V:V:E296	V:V:L293	3.98	No	No	0	7	8
716	V:V:H295	V:V:K294	2.62	No	No	0	7	9
717	V:V:N299	V:V:T298	4.39	Yes	No	0	8	8
718	V:V:H353	V:V:N299	8.93	No	Yes	2	8	8
719	V:V:L300	V:V:Y321	5.86	No	Yes	0	9	9
720	V:V:A301	V:V:V319	3.39	No	Yes	2	9	8
721	V:V:M352	V:V:S302	4.6	Yes	No	0	8	9
722	V:V:S303	V:V:T350	3.2	No	No	11	8	4
723	V:V:M352	V:V:S303	3.07	Yes	No	11	8	8
724	V:V:I318	V:V:T304	3.04	Yes	No	0	5	9
725	V:V:L305	V:V:M352	2.83	No	Yes	0	5	8
726	V:V:I318	V:V:L306	5.71	Yes	No	0	5	4
727	V:V:E308	V:V:R307	2.33	Yes	No	2	3	4
728	V:V:N311	V:V:R307	2.41	No	No	2	4	4
729	V:V:I314	V:V:R307	2.51	Yes	No	2	5	4
730	V:V:E308	V:V:N311	3.94	Yes	No	2	3	4
731	V:V:G316	V:V:I314	1.76	No	Yes	2	8	5
732	V:V:I314	V:V:I318	11.77	Yes	Yes	0	5	5
733	V:V:V319	V:V:Y321	2.52	Yes	Yes	2	8	9
734	V:V:K322	V:V:S320	3.06	Yes	No	9	5	8
735	V:V:F349	V:V:Y321	8.25	Yes	Yes	2	7	9
736	V:V:L351	V:V:Y321	4.69	No	Yes	2	8	9
737	V:V:E346	V:V:K322	13.5	No	Yes	9	8	5
738	V:V:K322	V:V:P348	13.38	Yes	No	0	5	9
739	V:V:F349	V:V:V323	3.93	Yes	No	2	7	7
740	V:V:K324	V:V:K326	8.62	No	No	0	6	7
741	V:V:A344	V:V:K324	3.21	No	No	0	4	6
742	V:V:V325	V:V:V345	3.21	No	Yes	3	8	7
743	V:V:D342	V:V:K326	11.06	No	No	0	7	7
744	V:V:L327	V:V:V343	4.47	No	Yes	0	7	7
745	V:V:S330	V:V:V328	1.62	No	No	3	6	4
746	V:V:R331	V:V:V329	3.92	No	No	0	5	6
747	V:V:S341	V:V:V329	1.62	No	No	19	8	6
748	V:V:D337	V:V:R331	13.1	Yes	No	0	5	5
749	V:V:G332	V:V:G333	2.11	No	No	20	5	7
750	V:V:D337	V:V:G332	1.68	Yes	No	20	5	5
751	V:V:D337	V:V:G333	5.03	Yes	No	20	5	7
752	V:V:D337	V:V:L335	2.71	Yes	No	0	5	4
753	V:V:D337	V:V:G336	1.68	Yes	No	0	5	5
754	V:V:L347	V:V:P348	1.64	Yes	No	0	6	9
755	V:V:F349	V:V:L351	2.44	Yes	No	2	7	8
756	V:V:M352	V:V:T350	7.53	Yes	No	11	8	4
757	R:R:C184	R:R:N183	1.57	No	No	0	1	3
758	V:V:E206	V:V:P182	1.57	No	Yes	2	7	9
759	R:R:A198	R:R:N196	1.56	No	No	0	4	4
760	R:R:I38	R:R:S41	1.55	No	No	0	5	4
761	R:R:I55	R:R:V52	1.54	Yes	No	0	7	3
762	R:R:I135	R:R:V222	1.54	No	Yes	0	9	8
763	R:R:I205	R:R:V206	1.54	No	No	0	4	4
764	V:V:A90	V:V:D93	1.54	No	No	0	1	1
765	R:R:K140	R:R:S137	1.53	No	No	0	5	6
766	V:V:M255	V:V:S234	1.53	No	No	0	3	5
767	R:R:M36	R:R:V39	1.52	No	No	0	5	5
768	V:V:K270	V:V:V218	1.52	Yes	No	0	8	7
769	V:V:A310	V:V:E308	1.51	No	Yes	0	4	3
770	R:R:K149	R:R:T146	1.5	Yes	No	0	5	8
771	V:V:K10	V:V:T19	1.5	No	No	0	9	7
772	R:R:L95	R:R:V33	1.49	No	No	0	6	4
773	V:V:N223	V:V:S265	1.49	No	No	0	6	8
774	V:V:N217	V:V:V271	1.48	No	No	0	6	5
775	R:R:I201	R:R:I205	1.47	No	No	0	5	4
776	R:R:I201	R:R:I294	1.47	No	No	0	5	6
777	V:V:L42	V:V:T19	1.47	No	No	0	5	7
778	R:R:N148	R:R:T146	1.46	No	No	0	4	8
779	R:R:I159	R:R:M156	1.46	No	No	0	4	4
780	V:V:D240	V:V:T246	1.45	No	No	0	6	7
781	R:R:L167	R:R:M171	1.41	No	No	0	5	4
782	V:V:K284	V:V:L287	1.41	No	Yes	0	8	7
783	R:R:L272	R:R:L275	1.38	No	No	0	7	8
784	R:R:I58	R:R:Q65	1.37	Yes	No	0	7	8
785	V:V:L154	V:V:N153	1.37	No	No	0	3	4
786	V:V:E118	V:V:K95	1.35	No	Yes	0	4	3
787	V:V:E257	V:V:M255	1.35	No	No	0	6	3
788	V:V:E102	V:V:L97	1.33	No	No	0	6	4
789	V:V:R7	V:V:T6	1.29	No	No	0	4	4
790	R:R:E180	R:R:Q179	1.27	No	No	0	3	3
791	V:V:K160	V:V:R161	1.24	No	No	0	8	7
792	R:R:N148	R:R:R151	1.21	No	No	0	4	3
793	V:V:L100	V:V:R103	1.21	No	No	0	5	6
794	V:V:F244	V:V:N245	1.21	No	No	0	8	8
795	V:V:R51	V:V:R52	1.07	No	No	0	6	6
796	R:R:R151	R:R:Y70	1.03	No	No	0	3	4
797	R:R:F101	R:R:W105	1	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.98824	17	1	0
2	R:R:M40	4.545	4	1	6
3	R:R:V44	3.19	4	1	6
4	R:R:I47	3.525	4	12	8
5	R:R:N51	6.96	4	12	9
6	R:R:L53	3.0375	4	13	6
7	R:R:I55	2.2625	4	0	7
8	R:R:I58	4.02	4	6	7
9	R:R:L64	2.7625	4	6	8
10	R:R:F71	4.63833	6	1	8
11	R:R:L75	5.08	5	1	9
12	R:R:D79	9.365	4	12	9
13	R:R:M82	4.5	5	1	7
14	R:R:G83	1.7975	4	0	7
15	R:R:V86	7.888	5	1	7
16	R:R:V87	3.865	4	1	7
17	R:R:W99	7.08833	6	1	7
18	R:R:W109	5.94625	8	1	5
19	R:R:T110	3.09667	6	1	4
20	R:R:S111	6.19	4	1	6
21	R:R:I112	3.016	5	1	4
22	R:R:D113	10.56	4	1	7
23	R:R:V114	2.565	6	1	5
24	R:R:L115	5.79	4	1	5
25	R:R:T118	4.22167	6	1	6
26	R:R:I121	4.64	4	1	7
27	R:R:E122	4.63	4	1	5
28	R:R:T123	3.4625	4	1	8
29	R:R:I127	3.52333	6	1	9
30	R:R:D130	5.8425	4	1	8
31	R:R:Y132	7.53	5	1	8
32	R:R:Y141	6.096	5	1	7
33	R:R:K149	4.6825	4	0	5
34	R:R:W158	3.3	6	1	9
35	R:R:S161	3.9975	4	1	8
36	R:R:S165	5.525	4	1	7
37	R:R:F166	6.49667	6	1	4
38	R:R:I169	8.5925	4	1	5
39	R:R:Y174	7.03833	6	1	5
40	R:R:Y185	3.7275	4	1	1
41	R:R:C191	4.2	4	1	9
42	R:R:F193	8.6675	4	1	4
43	R:R:F194	7.0575	4	1	1
44	R:R:T195	5.316	5	1	3
45	R:R:Y199	6.08571	7	1	6
46	R:R:S203	6.6225	4	1	5
47	R:R:S207	5.31	4	1	5
48	R:R:F208	8.21333	6	1	8
49	R:R:M215	4.345	4	1	8
50	R:R:V218	3.912	5	1	6
51	R:R:Y219	5.228	5	1	9
52	R:R:V222	2.3625	4	1	8
53	R:R:R273	7.055	4	1	7
54	R:R:T281	3.208	5	1	6
55	R:R:F282	4.28714	7	1	9
56	R:R:C285	2.334	5	0	9
57	R:R:W286	6.59667	9	1	8
58	R:R:F289	7.21286	7	1	6
59	R:R:F290	7.23286	7	1	7
60	R:R:N293	5.475	4	1	5
61	R:R:Y308	4.605	4	1	5
62	R:R:L311	3.255	4	0	5
63	R:R:W313	4.536	5	1	5
64	R:R:Y316	6.59333	6	1	6
65	R:R:N318	6.01	4	1	9
66	R:R:S319	5.645	4	0	9
67	R:R:F321	5.772	5	1	6
68	R:R:P323	3.37	5	0	9
69	R:R:I325	3.745	4	1	8
70	R:R:Y326	4.86333	6	1	9
71	R:R:F332	7.21	4	0	9
72	R:R:R333	6.18	5	7	9
73	V:V:K17	5.295	4	15	5
74	V:V:V20	3.405	4	2	6
75	V:V:Y21	8.92	6	4	8
76	V:V:L22	4.385	4	2	8
77	V:V:R25	5.7175	4	2	9
78	V:V:V37	5.49	4	2	8
79	V:V:V40	4.34333	6	4	8
80	V:V:V43	4.61	5	8	6
81	V:V:Y47	3.0925	4	8	5
82	V:V:Y54	12.4375	4	5	4
83	V:V:V55	3.682	5	2	8
84	V:V:L57	4.695	4	2	7
85	V:V:C59	3.985	6	2	8
86	V:V:F61	8.9275	4	2	9
87	V:V:R62	4.48	4	10	8
88	V:V:R76	4.175	4	10	8
89	V:V:K77	9.0075	4	2	9
90	V:V:L79	3.994	5	2	8
91	V:V:N83	5.3975	4	5	5
92	V:V:F87	4.546	5	8	4
93	V:V:K95	6.185	4	16	3
94	V:V:Q101	8.97	4	4	9
95	V:V:L104	9.5075	4	4	9
96	V:V:L108	3.6575	4	4	8
97	V:V:F115	4.748	5	2	9
98	V:V:F117	6.69	5	2	8
99	V:V:L123	7.86	6	2	6
100	V:V:P124	3.12	5	2	9
101	V:V:V127	2.4225	4	2	8
102	V:V:P131	4.586	5	0	8
103	V:V:G132	3.86	4	18	6
104	V:V:Y144	7.5625	4	2	7
105	V:V:E145	5.44	5	10	7
106	V:V:F149	6.326	5	5	5
107	V:V:V164	4.765	4	0	8
108	V:V:I168	3.825	6	2	8
109	V:V:R169	4.84833	6	2	9
110	V:V:Q172	6.8325	4	2	9
111	V:V:Y173	6.0525	4	2	4
112	V:V:P182	4.0575	4	2	9
113	V:V:E185	6.27	5	7	5
114	V:V:M192	5.6625	4	19	7
115	V:V:K195	4.584	5	1	7
116	V:V:L203	4.596	5	2	8
117	V:V:I207	3.388	5	11	5
118	V:V:Y208	6.25333	6	2	6
119	V:V:H210	9.05	5	2	9
120	V:V:I214	8.0075	4	2	8
121	V:V:N222	4.13	4	3	9
122	V:V:K229	10.155	4	3	8
123	V:V:K230	7.196	5	3	5
124	V:V:I233	4.6475	4	3	5
125	V:V:Q237	6.554	5	2	9
126	V:V:Y238	9.33333	6	9	4
127	V:V:I241	5.1275	4	0	8
128	V:V:K270	9.1375	4	3	8
129	V:V:Y272	5.47	4	3	4
130	V:V:L287	4.14	5	2	7
131	V:V:G291	2.09	4	2	9
132	V:V:K292	5.2675	4	0	6
133	V:V:N299	6.925	4	2	8
134	V:V:E308	2.622	5	2	3
135	V:V:I314	4.4325	4	2	5
136	V:V:I317	4.3875	4	2	8
137	V:V:I318	6.18	4	0	5
138	V:V:V319	2.705	4	2	8
139	V:V:Y321	6.744	5	2	9
140	V:V:K322	10.47	4	9	5
141	V:V:D337	4.84	5	20	5
142	V:V:V343	4.2725	4	0	7
143	V:V:V345	3.2925	4	3	7
144	V:V:L347	2.73	4	2	6
145	V:V:F349	4.435	6	2	7
146	V:V:M352	3.76	6	11	8
147	W:W:?1	8.07857	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V117	18.9446	5.86	Yes	No	1	0	6
2	R:R:V117	R:R:W286	24.0661	4.9	No	Yes	1	6	8
3	R:R:G315	R:R:W286	31.1497	7.04	No	Yes	0	7	8
4	R:R:C285	R:R:G315	31.3091	1.96	Yes	No	0	9	7
5	L:L:?1	R:R:F289	19.0665	6.39	Yes	Yes	1	0	6
6	R:R:F289	R:R:W286	20.3457	7.02	Yes	Yes	1	6	8
7	L:L:?1	R:R:F290	26.4329	7.19	Yes	Yes	1	0	7
8	R:R:F290	R:R:W286	19.7127	10.02	Yes	Yes	1	7	8
9	R:R:N318	R:R:W286	31.6089	12.43	Yes	Yes	1	9	8
10	R:R:C285	R:R:N318	34.7183	4.72	Yes	Yes	0	9	9
11	L:L:?1	R:R:W109	15.4681	2.99	Yes	Yes	1	0	5
12	L:L:?1	R:R:V114	10.9149	1.95	Yes	Yes	1	0	5
13	R:R:W109	R:R:W99	10.5212	13.12	Yes	Yes	1	5	7
14	L:L:?1	R:R:T195	15.9188	2.9	Yes	Yes	1	0	3
15	R:R:V114	R:R:Y199	11.0399	3.79	Yes	Yes	1	5	6
16	L:L:?1	R:R:S203	15.6611	11.82	Yes	Yes	1	0	5
17	R:R:F282	R:R:W286	16.2184	5.01	Yes	Yes	1	9	8
18	R:R:P168	R:R:Y199	15.2503	4.17	No	Yes	0	5	6
19	R:R:L167	R:R:P168	15.8413	3.28	No	No	0	5	5
20	R:R:F282	R:R:T283	23.8539	2.59	Yes	No	0	9	7
21	R:R:G280	R:R:T283	28.5132	3.64	No	No	0	5	7
22	R:R:G280	W:W:?1	28.5275	2.44	No	Yes	0	5	0
23	R:R:C285	R:R:T281	33.0347	1.69	Yes	Yes	0	9	6
24	R:R:T281	W:W:?1	33.5977	5.61	Yes	Yes	1	6	0
25	R:R:C285	R:R:L284	31.3455	1.59	Yes	No	0	9	5
26	R:R:L284	W:W:?1	31.3471	7.9	No	Yes	0	5	0
27	V:V:R188	W:W:?1	95.1777	2.89	No	Yes	0	8	0
28	V:V:R188	V:V:S193	99.0404	2.64	No	No	0	8	9
29	V:V:S193	V:V:V343	98.8278	3.23	No	Yes	0	9	7
30	V:V:T186	V:V:V343	99.4027	6.35	No	Yes	0	7	7
31	V:V:T186	V:V:V345	99.2938	3.17	No	Yes	0	7	7
32	V:V:A184	V:V:V345	100	5.09	No	Yes	0	5	7
33	V:V:A184	V:V:L347	99.8855	1.58	No	Yes	0	5	6
34	V:V:L203	V:V:L347	97.3221	2.77	Yes	Yes	2	8	6
35	V:V:L203	V:V:Y208	46.9834	3.52	Yes	Yes	2	8	6
36	V:V:F349	V:V:Y208	45.4798	3.09	Yes	Yes	2	7	6
37	V:V:F349	V:V:L351	53.7579	2.44	Yes	No	2	7	8
38	V:V:H210	V:V:L351	53.4921	16.71	Yes	No	2	9	8
39	V:V:H210	V:V:N299	46.6903	7.65	Yes	Yes	2	9	8
40	V:V:D290	V:V:N299	44.4759	6.73	No	Yes	2	9	8
41	V:V:D290	V:V:R169	43.2101	4.76	No	Yes	2	9	9
42	V:V:L293	V:V:R169	39.5554	4.86	No	Yes	0	8	9
43	V:V:L293	V:V:R25	39.592	6.07	No	Yes	0	8	9
44	V:V:I214	V:V:L203	50.267	7.14	Yes	Yes	2	8	8
45	V:V:F349	V:V:I214	45.297	6.28	Yes	Yes	2	7	8
46	V:V:L166	V:V:R25	35.0599	12.15	No	Yes	2	8	9
47	V:V:L166	V:V:L22	35.1589	5.54	No	Yes	2	8	8
48	V:V:L22	V:V:V20	25.9343	2.98	Yes	Yes	2	8	6
49	V:V:V20	V:V:V41	24.1807	4.81	Yes	No	0	6	5
50	V:V:V41	V:V:V43	23.8541	3.21	No	Yes	0	5	6
51	V:V:F87	V:V:V43	20.9146	6.55	Yes	Yes	8	4	6
52	V:V:F349	V:V:Y321	36.1296	8.25	Yes	Yes	2	7	9
53	V:V:V319	V:V:Y321	20.2142	2.52	Yes	Yes	2	8	9
54	V:V:V127	V:V:V319	19.2857	3.21	Yes	Yes	2	8	8
55	V:V:I317	V:V:V127	15.2179	3.07	Yes	Yes	2	8	8
56	V:V:I317	V:V:V142	12.5845	4.61	Yes	No	2	8	9
57	V:V:L123	V:V:V142	12.3055	5.96	Yes	No	2	6	9
58	V:V:F87	V:V:P88	16.3177	2.89	Yes	No	0	4	9
59	V:V:P88	V:V:R52	14.3363	5.76	No	No	0	9	6
60	V:V:R52	V:V:Y54	13.6748	13.38	No	Yes	0	6	4
61	V:V:L287	V:V:Q130	13.5769	6.65	Yes	No	0	7	9
62	V:V:P131	V:V:Q130	11.2193	3.16	Yes	No	0	8	9
63	R:R:W286	R:R:Y316	14.6385	2.89	Yes	Yes	1	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W109	2.99	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T110	2.9	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D113	8.01	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V114	1.95	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V117	5.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:T118	1.93	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D192	1.78	1	Yes	No	0	3	0	1
L:L:?1	R:R:F193	17.57	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T195	2.9	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:S203	11.82	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:S207	5.91	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F289	6.39	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F290	7.19	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N293	2.7	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y308	4.61	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I309	4.68	1	Yes	No	0	3	0	1
L:L:?1	R:R:N312	12.61	1	Yes	No	0	5	0	1
R:R:V86	R:R:W109	7.36	1	Yes	Yes	7	5	2	1
R:R:D113	R:R:V86	16.07	1	Yes	Yes	7	7	1	2
R:R:V86	R:R:Y316	3.79	1	Yes	Yes	7	6	2	2
R:R:F89	R:R:W99	4.01	1	No	Yes	5	7	2	2
R:R:F89	R:R:W109	7.02	1	No	Yes	5	5	2	1
R:R:G90	R:R:W109	4.22	0	No	Yes	7	5	2	1
R:R:I309	R:R:I94	5.89	1	No	No	3	5	1	2
R:R:I94	R:R:W313	2.35	1	No	Yes	5	5	2	2
R:R:W109	R:R:W99	13.12	1	Yes	Yes	5	7	1	2
R:R:C191	R:R:W99	5.22	1	Yes	Yes	9	7	2	2
R:R:T110	R:R:W109	2.43	1	Yes	Yes	4	5	1	1
R:R:D113	R:R:W109	7.82	1	Yes	Yes	7	5	1	1
R:R:C191	R:R:W109	2.61	1	Yes	Yes	9	5	2	1
R:R:T110	R:R:V114	1.59	1	Yes	Yes	4	5	1	1
R:R:I169	R:R:T110	6.08	1	Yes	Yes	5	4	2	1
R:R:C191	R:R:T110	1.69	1	Yes	Yes	9	4	2	1
R:R:F193	R:R:T110	3.89	1	Yes	Yes	4	4	1	1
R:R:D113	R:R:Y316	10.34	1	Yes	Yes	7	6	1	2
R:R:T118	R:R:V114	1.59	1	Yes	Yes	6	5	1	1
R:R:S165	R:R:V114	4.85	1	Yes	Yes	7	5	2	1
R:R:V114	R:R:Y199	3.79	1	Yes	Yes	5	6	1	2
R:R:S203	R:R:V114	1.62	1	Yes	Yes	5	5	1	1
R:R:T118	R:R:V117	1.59	1	Yes	No	6	6	1	1
R:R:V117	R:R:W286	4.9	1	No	Yes	6	8	1	2
R:R:E122	R:R:T118	4.23	1	Yes	Yes	5	6	2	1
R:R:S161	R:R:T118	6.4	1	Yes	Yes	8	6	2	1
R:R:S207	R:R:T118	9.59	1	Yes	Yes	5	6	1	1
R:R:I121	R:R:S207	3.1	1	Yes	Yes	7	5	2	1
R:R:I121	R:R:W286	7.05	1	Yes	Yes	7	8	2	2
R:R:E122	R:R:S161	4.31	1	Yes	Yes	5	8	2	2
R:R:S203	R:R:T164	1.6	1	Yes	No	5	5	1	2
R:R:I169	R:R:Y174	13.3	1	Yes	Yes	5	5	2	2
R:R:I169	R:R:Y199	7.25	1	Yes	Yes	5	6	2	2
R:R:T195	R:R:Y174	3.75	1	Yes	Yes	3	5	1	2
R:R:Y174	R:R:Y199	4.96	1	Yes	Yes	5	6	2	2
R:R:D192	R:R:F194	15.52	1	No	Yes	3	1	1	2
R:R:D192	R:R:K305	2.77	1	No	No	3	2	1	2
R:R:F193	R:R:T195	9.08	1	Yes	Yes	4	3	1	1
R:R:F193	R:R:Y308	4.13	1	Yes	Yes	4	5	1	1
R:R:F194	R:R:K305	3.72	1	Yes	No	1	2	2	2
R:R:T195	R:R:Y199	7.49	1	Yes	Yes	3	6	1	2
R:R:A200	R:R:T195	3.36	0	No	Yes	5	3	2	1
R:R:S203	R:R:Y199	11.45	1	Yes	Yes	5	6	1	2
R:R:F290	R:R:S204	2.64	1	Yes	No	7	5	1	2
R:R:F290	R:R:S207	2.64	1	Yes	Yes	7	5	1	1
R:R:F208	R:R:W286	3.01	1	Yes	Yes	8	8	2	2
R:R:F208	R:R:F290	21.43	1	Yes	Yes	8	7	2	1
R:R:F289	R:R:W286	7.02	1	Yes	Yes	6	8	1	2
R:R:F290	R:R:W286	10.02	1	Yes	Yes	7	8	1	2
R:R:W286	R:R:Y316	2.89	1	Yes	Yes	8	6	2	2
R:R:F289	R:R:F290	4.29	1	Yes	Yes	6	7	1	1
R:R:F289	R:R:N293	13.29	1	Yes	Yes	6	5	1	1
R:R:F289	R:R:Y308	6.19	1	Yes	Yes	6	5	1	1
R:R:F289	R:R:L311	2.44	1	Yes	Yes	6	5	1	2
R:R:F289	R:R:N312	10.87	1	Yes	No	6	5	1	1
R:R:F290	R:R:N293	2.42	1	Yes	Yes	7	5	1	1
R:R:N293	R:R:Y308	3.49	1	Yes	Yes	5	5	1	1
R:R:I309	R:R:W313	2.35	1	No	Yes	3	5	1	2
R:R:N312	R:R:Y316	9.3	1	No	Yes	5	6	1	2
R:R:W313	R:R:Y316	9.65	1	Yes	Yes	5	6	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K270	R:R:R273	3.71	0	No	Yes	7	7	2	1
R:R:R273	V:V:F190	14.97	1	Yes	No	7	9	1	2
R:R:R273	V:V:L191	6.07	1	Yes	No	7	5	1	1
R:R:R273	W:W:?1	3.47	1	Yes	Yes	7	0	1	0
R:R:S276	W:W:?1	7.86	0	No	Yes	6	0	1	0
R:R:T281	R:R:V277	1.59	1	Yes	No	6	7	1	1
R:R:I325	R:R:V277	3.07	1	Yes	No	8	7	2	1
R:R:V277	W:W:?1	4.96	1	No	Yes	7	0	1	0
R:R:G280	R:R:T283	3.64	0	No	No	5	7	1	2
R:R:G280	W:W:?1	2.44	0	No	Yes	5	0	1	0
R:R:C285	R:R:T281	1.69	0	Yes	Yes	9	6	2	1
R:R:F321	R:R:T281	2.59	1	Yes	Yes	6	6	1	1
R:R:I325	R:R:T281	4.56	1	Yes	Yes	8	6	2	1
R:R:T281	W:W:?1	5.61	1	Yes	Yes	6	0	1	0
R:R:C285	R:R:L284	1.59	0	Yes	No	9	5	2	1
R:R:L284	W:W:?1	7.9	0	No	Yes	5	0	1	0
R:R:C285	R:R:V317	1.71	0	Yes	No	9	5	2	2
R:R:F321	R:R:V317	7.87	1	Yes	No	6	5	1	2
R:R:F321	R:R:I325	2.51	1	Yes	Yes	6	8	1	2
R:R:F321	V:V:K195	3.72	1	Yes	Yes	6	7	1	1
R:R:F321	W:W:?1	12.17	1	Yes	Yes	6	0	1	0
R:R:L324	R:R:P323	1.64	0	No	Yes	6	9	1	2
R:R:L324	V:V:P196	3.28	0	No	No	6	6	1	2
R:R:L324	W:W:?1	2.63	0	No	Yes	6	0	1	0
R:R:R328	V:V:R188	10.66	0	No	No	7	8	2	1
V:V:R188	V:V:S193	2.64	0	No	No	8	9	1	2
V:V:R188	W:W:?1	2.89	0	No	Yes	8	0	1	0
V:V:G336	V:V:L191	1.71	0	No	No	5	5	2	1
V:V:L191	W:W:?1	7.9	1	No	Yes	5	0	1	0
V:V:D194	W:W:?1	43.92	0	No	Yes	6	0	1	0
V:V:K195	V:V:P196	6.69	1	Yes	No	7	6	1	2
V:V:K195	V:V:T224	3	1	Yes	No	7	9	1	2
V:V:K195	V:V:N225	2.8	1	Yes	No	7	5	1	1
V:V:K195	W:W:?1	6.71	1	Yes	Yes	7	0	1	0
V:V:K226	V:V:N225	5.6	1	No	No	8	5	1	1
V:V:N225	W:W:?1	1.96	1	No	Yes	5	0	1	0
V:V:K226	V:V:R331	17.33	1	No	No	8	5	1	2
V:V:K226	W:W:?1	2.68	1	No	Yes	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L8L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.58
Number of Linked Nodes	581
Number of Links	797
Number of Hubs	147
Number of Links mediated by Hubs	532
Number of Communities	20
Number of Nodes involved in Communities	251
Number of Links involved in Communities	388

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	1946420
Length Of Smallest Path	3
Average Path Length	26.0484
Length of Longest Path	50
Minimum Path Strength	1.12
Average Path Strength	5.06378
Maximum Path Strength	28.045
Minimum Path Correlation	0.7
Average Path Correlation	0.985389
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	58.1478
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.0703
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • bone mineralization • animal organ development • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • negative regulation of cardiac muscle cell apoptotic process • muscle cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • cardiac muscle cell apoptotic process • negative regulation of apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • negative regulation of muscle cell apoptotic process • negative regulation of cellular process • negative regulation of striated muscle cell apoptotic process • apoptotic process • programmed cell death • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • heart process • regulation of actin filament-based process • regulation of heart contraction • cardiac muscle contraction • striated muscle contraction • circulatory system process • actin filament-based process • positive regulation of actin filament-based movement • blood circulation • cardiac muscle cell contraction • regulation of cardiac muscle contraction • positive regulation of cardiac muscle cell contraction • actin filament-based movement • regulation of blood circulation • regulation of striated muscle contraction • regulation of actin filament-based movement • regulation of cardiac muscle cell contraction • actin-mediated cell contraction • heart contraction • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • positive regulation of striated muscle cell apoptotic process • positive regulation of apoptotic process • positive regulation of muscle cell apoptotic process • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • arrestin family protein binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • angiotensin receptor binding • signaling receptor binding • G protein-coupled receptor binding • molecular adaptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • insulin-like growth factor receptor binding • molecular function inhibitor activity • enzyme inhibitor activity • transcription coactivator activity • transcription regulator activity • transcription coregulator activity • protein-macromolecule adaptor activity • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • interleukin-6 production • multicellular organismal process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • negative regulation of post-translational protein modification • regulation of protein modification process • regulation of protein ubiquitination • regulation of primary metabolic process • protein ubiquitination • negative regulation of protein modification process • protein metabolic process • negative regulation of protein ubiquitination • regulation of protein modification by small protein conjugation or removal • protein modification process • negative regulation of protein metabolic process • negative regulation of protein modification by small protein conjugation or removal • regulation of post-translational protein modification • regulation of protein metabolic process • primary metabolic process • macromolecule modification • post-translational protein modification • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • actomyosin structure organization • actin cytoskeleton organization • actin filament organization • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • actin filament bundle organization • contractile actin filament bundle assembly • actin filament-based process • actin filament bundle assembly • stress fiber assembly • cellular component organization or biogenesis • supramolecular fiber organization • cytoskeleton organization • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • system process • sensory perception • nervous system process • catabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • regulation of system process • positive regulation of biological process • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • positive regulation of multicellular organismal process • negative regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • import into cell • receptor internalization • transport • vesicle-mediated transport • localization • G protein-coupled receptor internalization • establishment of localization • receptor-mediated endocytosis • endocytosis • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • establishment of protein localization • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • proteasomal protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of phosphorus metabolic process • regulation of phosphorylation • pseudopodium • clathrin-coated pit • cytosol • chromatin • chromosome • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • Golgi membrane • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • nuclear body • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • synapse • cell junction • cell body • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P0G
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P0G
Name	8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one
Synonyms
Identifier
Formula	C21 H26 N2 O4
Molecular Weight	370.442
SMILES
PubChem	49837874
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	1
Total Bonds	55
Total Aromatic Bonds	12


Code	DR7
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	DR7
Name	Atazanavir
Synonyms	ATAZANAVIR; METHYL [(1S,4S,5S,10S)-4-BENZYL-1,10-DI-TERT-BUTYL-5-HYDROXY-2,9,12-TRIOXO-7-(4-PYRIDIN-2-YLBENZYL)-13-OXA-3,7,8,11-TETRAAZATETRADEC-1-YL]CARBAMATE
Identifier
Formula	C38 H52 N6 O7
Molecular Weight	704.855
SMILES
PubChem	148192
Formal Charge	0
Total Atoms	103
Total Chiral Atoms	4
Total Bonds	105
Total Aromatic Bonds	19


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>9L8L_nogp_Chain_R E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K M W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R Q E A I N C Y A N E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R E H K A L T L I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L C R S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P49407
Sequence	>9L8L_nogp_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V D P V D G V V L V D P E Y L K E R R V Y V T L T C A F R Y F R K D L F V A N V Q S F P P A P E D K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P C S V T L Q P G P E D T G K A C G V D Y E V K A F C A E N L E E K I H K R N S V R L V I R K V Q Y A P E R P G P Q P T A E T T R Q F L M S D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I C L F N T A Q Y K C P V A M E E A D D T V A P S S T F C K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V S R G G L L G D L A S S D V A V E L P F T L M H P K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 913103	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	FAUC50	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzyl Isoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 76210628	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	PubChem 129318963	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8GE2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ1	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ1	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Norepinephrine	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	doi.org/10.1073/pnas.2414544121
	9U9V	A	Amine	Adrenergic	β₂	Homo sapiens	METH	-	Gs/β1/γ2	2.85	2025-09-03	To be published
	9U9V (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	METH	-		2.85	2025-09-03	To be published
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9M55	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-	chim(NtGi1-Gs)/β1/γ2	3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M55 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-		3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-	chim(NtGi1-Gs)/β1/γ2	3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-		3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9L8L	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	Atazanavir	Gs/β1/γ2 ; Arrestin2	3.22	2025-12-31	To be published
	9L8L (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	Atazanavir		3.22	2025-12-31	To be published

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