CodeP0G
Name8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one
Synonyms
Identifier5-hydroxy-8-[(1R)-1-hydroxy-2-[[2-methyl-1-(2-methylphenyl)propan-2-yl]amino]ethyl]-4H-1,4-benzoxazin-3-one
FormulaC21 H26 N2 O4
Molecular Weight370.442
SMILESCc1ccccc1CC(C)(C)NC[C@@H](c2ccc(c3c2OCC(=O)N3)O)O
PubChem49837874
Formal Charge0
Total Atoms53
Total Chiral Atoms1
Total Bonds55
Total Aromatic Bonds12
Networks7
 missing image

This ligand is also present in the following 7 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3P0G A Amine Adrenergic Beta2 Homo sapiens BI167107 - - 3.5 2011-01-19 10.1038/nature09648

A 2D representation of the interactions of P0G in 3P0G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V86 R:R:W109 6.13 1 No Yes 7 5 2 1
R:R:D113 R:R:V86 5.84 1 Yes No 7 7 1 2
R:R:F89 R:R:W109 7.02 0 No Yes 5 5 2 1
R:R:W109 R:R:W99 4.69 1 Yes Yes 5 7 1 2
R:R:D113 R:R:W109 4.47 1 Yes Yes 7 5 1 1
L:L:?1 R:R:W109 6.72 1 Yes Yes 0 5 0 1
R:R:D113 R:R:Y316 11.49 1 Yes Yes 7 6 1 2
L:L:?1 R:R:D113 20.47 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V114 9.77 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 6.84 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No Yes 5 6 1 2
R:R:F193 R:R:Y174 5.16 1 No Yes 4 5 1 2
R:R:T195 R:R:Y174 6.24 1 Yes Yes 3 5 2 2
R:R:F193 R:R:T195 10.38 1 No Yes 4 3 1 2
L:L:?1 R:R:F193 19.97 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 8.74 1 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.88 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 5.91 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 6.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 6.43 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 6.04 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 13.41 1 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 24.17 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.99 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 10.38 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 1 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 11.71 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y308 4.61 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 6.98 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 13.51 1 Yes No 0 5 0 1
L:L:?1 R:R:I309 3.74 1 Yes No 0 3 0 1
R:R:I309 R:R:K305 2.91 0 No No 3 2 1 2
R:R:V292 R:R:Y308 2.52 0 No Yes 5 5 2 1
R:R:G90 R:R:W109 1.41 0 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.96
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3SN6 A Amine Adrenergic Beta2 Homo sapiens BI167107 - Gs/Beta1/Gamma2 3.2 2011-07-20 10.1038/nature10361

A 2D representation of the interactions of P0G in 3SN6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 2 No No 7 7 1 2
R:R:V86 R:R:Y316 5.05 2 No Yes 7 6 2 2
R:R:F89 R:R:W109 9.02 2 No Yes 5 5 2 1
R:R:W109 R:R:W99 17.81 2 Yes Yes 5 7 1 2
R:R:T110 R:R:W109 3.64 2 No Yes 4 5 1 1
L:L:?1 R:R:W109 6.72 2 Yes Yes 0 5 0 1
R:R:I169 R:R:T110 3.04 2 Yes No 5 4 2 1
L:L:?1 R:R:T110 2.9 2 Yes No 0 4 0 1
R:R:D113 R:R:Y316 11.49 2 No Yes 7 6 1 2
L:L:?1 R:R:D113 17.8 2 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 2 Yes No 7 5 2 1
R:R:I169 R:R:V114 3.07 2 Yes No 5 5 2 1
L:L:?1 R:R:V114 7.82 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 11.03 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 6.84 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 2 No No 4 3 1 2
R:R:F193 R:R:Y308 8.25 2 No Yes 4 5 1 1
L:L:?1 R:R:F193 27.95 2 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 13.99 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.85 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 2 Yes Yes 7 5 1 2
R:R:N293 R:R:S204 4.47 2 Yes Yes 5 5 1 2
L:L:?1 R:R:S207 3.94 2 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 2 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 18.22 2 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 5.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 2 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 2 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 11.35 2 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 6.09 2 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 20.54 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.19 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 8.79 2 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 2 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 11.71 2 Yes Yes 0 5 0 1
R:R:K305 R:R:Y308 7.17 0 No Yes 2 5 2 1
L:L:?1 R:R:Y308 6.15 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 6.98 2 No Yes 5 6 1 2
L:L:?1 R:R:N312 13.51 2 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.09
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4LDE A Amine Adrenergic Beta2 Homo sapiens BI167107 - - 2.79 2013-09-25 10.1038/nature12572

A 2D representation of the interactions of P0G in 4LDE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 4.56 2 Yes No 7 7 2 2
R:R:M82 R:R:Y316 5.99 2 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 2 No No 7 7 1 2
R:R:V86 R:R:Y316 5.05 2 No Yes 7 6 2 1
R:R:G90 R:R:W109 4.22 0 No No 7 5 2 1
R:R:W109 R:R:W99 6.56 0 No Yes 5 7 1 2
L:L:?401 R:R:W109 5.23 2 Yes No 0 5 0 1
L:L:?401 R:R:T110 3.87 2 Yes No 0 4 0 1
R:R:D113 R:R:Y316 10.34 2 No Yes 7 6 1 1
L:L:?401 R:R:D113 21.36 2 Yes No 0 7 0 1
L:L:?401 R:R:V114 14.65 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?401 R:R:V117 5.86 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No Yes 4 3 1 2
L:L:?401 R:R:F193 17.57 2 Yes No 0 4 0 1
R:R:T195 R:R:Y199 7.49 1 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 10.17 0 No Yes 5 6 1 2
L:L:?401 R:R:S203 7.88 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 2 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 0 No No 5 5 1 2
L:L:?401 R:R:S207 5.91 2 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 11.79 2 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 11.35 2 Yes No 6 5 1 2
R:R:F289 R:R:N312 16.92 2 Yes No 6 5 1 1
L:L:?401 R:R:F289 9.58 2 Yes Yes 0 6 0 1
L:L:?401 R:R:F290 7.19 2 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 0 No No 5 5 1 2
L:L:?401 R:R:N293 9 2 Yes No 0 5 0 1
R:R:I309 R:R:K305 4.36 0 No No 3 2 1 2
L:L:?401 R:R:I309 5.62 2 Yes No 0 3 0 1
R:R:N312 R:R:Y316 11.63 2 No Yes 5 6 1 1
L:L:?401 R:R:N312 13.51 2 Yes No 0 5 0 1
R:R:W313 R:R:Y316 13.5 0 Yes Yes 5 6 2 1
L:L:?401 R:R:Y316 5.38 2 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.47
Average Nodes In Shell28.00
Average Hubs In Shell12.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6E67 A Amine Adrenergic Beta2 Homo sapiens BI167107 - Gs (fused) 3.7 2019-06-05 10.1016/j.cell.2019.04.021

A 2D representation of the interactions of P0G in 6E67
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 1 No No 7 7 1 2
R:R:V86 R:R:Y316 6.31 1 No Yes 7 6 2 2
R:R:F89 R:R:W109 11.02 0 No Yes 5 5 2 1
R:R:W109 R:R:W99 8.43 0 Yes Yes 5 7 1 2
L:L:?1 R:R:W109 4.48 1 Yes Yes 0 5 0 1
R:R:D113 R:R:Y316 8.05 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 20.47 1 Yes No 0 7 0 1
L:L:?1 R:R:V114 14.65 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 13.48 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 5.86 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 4.8 0 No No 5 6 1 2
R:R:F193 R:R:T195 11.67 0 No No 4 3 1 2
L:L:?1 R:R:F193 19.97 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 5 No Yes 3 6 2 2
R:R:S203 R:R:Y199 11.45 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.85 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 0 No No 5 5 1 2
L:L:?1 R:R:S207 4.92 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 0 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 8.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 13.93 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 9.28 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.99 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.59 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 9.3 0 No No 5 5 1 2
L:L:?1 R:R:N293 8.1 1 Yes No 0 5 0 1
L:L:?1 R:R:I309 3.74 1 Yes No 0 3 0 1
R:R:N312 R:R:Y316 6.98 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 11.71 1 Yes No 0 5 0 1
R:R:G90 R:R:W109 2.81 0 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.78
Average Nodes In Shell25.00
Average Hubs In Shell9.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6N48 A Amine Adrenergic Beta2 Homo sapiens BI167107 PubChem 138454256 - 3.2 2019-06-26 10.1126/science.aaw8981

A 2D representation of the interactions of P0G in 6N48
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 7.61 1 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 4.79 1 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 3.68 1 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
L:L:?1 R:R:T110 3.87 1 Yes No 0 4 0 1
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 18.69 1 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 12.7 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 5.86 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 21.56 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 3 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 11.45 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.88 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
L:L:?1 R:R:S207 5.91 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 21.43 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 6.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 15 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.58 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.99 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 0 No No 5 5 1 2
L:L:?1 R:R:N293 9 1 Yes No 0 5 0 1
R:R:I309 R:R:K305 5.82 0 No No 3 2 1 2
L:L:?1 R:R:I309 5.62 1 Yes No 0 3 0 1
R:R:N312 R:R:Y316 13.96 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 14.41 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 14.47 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 6.15 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.94
Average Nodes In Shell26.00
Average Hubs In Shell13.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6NI3 A Amine Adrenergic Beta2 Homo sapiens BI167107 - Gs/Beta1/Gamma2 3.8 2019-11-20 10.1038/s41594-019-0330-y

A 2D representation of the interactions of P0G in 6NI3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V117 4.56 0 Yes No 7 6 2 1
R:R:M82 R:R:Y316 3.59 0 Yes Yes 7 6 2 2
R:R:D113 R:R:V86 7.3 2 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 2 No Yes 7 6 2 2
R:R:F89 R:R:W109 5.01 0 No Yes 5 5 2 1
R:R:G90 R:R:W109 2.81 0 No Yes 7 5 2 1
R:R:H93 R:R:W99 20.1 2 No Yes 4 7 1 2
R:R:C191 R:R:H93 2.95 2 No No 9 4 2 1
L:L:?1 R:R:H93 5.9 2 Yes No 0 4 0 1
R:R:W109 R:R:W99 18.74 0 Yes Yes 5 7 1 2
R:R:C191 R:R:W99 15.67 2 No Yes 9 7 2 2
R:R:T110 R:R:W109 3.64 0 No Yes 4 5 2 1
L:L:?1 R:R:W109 6.72 2 Yes Yes 0 5 0 1
R:R:D113 R:R:Y316 10.34 2 No Yes 7 6 1 2
L:L:?1 R:R:D113 15.13 2 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 21 Yes No 7 5 2 1
L:L:?1 R:R:V114 8.79 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 6.84 2 Yes No 0 6 0 1
L:L:?1 R:R:F193 11.18 2 Yes No 0 4 0 1
R:R:S203 R:R:Y199 13.99 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 3.94 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 2 Yes No 7 5 1 1
R:R:N293 R:R:S204 2.98 2 Yes No 5 5 1 1
L:L:?1 R:R:S204 2.95 2 Yes No 0 5 0 1
R:R:F208 R:R:Y209 7.22 2 Yes Yes 8 5 2 2
R:R:F208 R:R:F290 21.43 2 Yes Yes 8 7 2 1
R:R:F290 R:R:Y209 4.13 2 Yes Yes 7 5 1 2
R:R:F289 R:R:W286 3.01 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 4.29 2 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 7.25 2 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 9.67 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.58 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.59 2 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 2 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 10.81 2 Yes Yes 0 5 0 1
L:L:?1 R:R:Y308 3.84 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 16.28 2 No Yes 5 6 1 2
L:L:?1 R:R:N312 13.51 2 Yes No 0 5 0 1
R:R:V292 R:R:Y308 2.52 0 No Yes 5 5 2 1
R:R:H296 R:R:Y308 2.18 0 No Yes 3 5 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.06
Average Nodes In Shell29.00
Average Hubs In Shell14.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7BU7 A Amine Adrenergic Beta1 Homo sapiens BI167107 - - 2.6 2020-12-02 10.1038/s41422-020-00424-2

A 2D representation of the interactions of P0G in 7BU7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M107 R:R:V111 7.61 1 Yes No 7 7 2 2
R:R:M107 R:R:Y367 3.59 1 Yes Yes 7 8 2 1
R:R:D138 R:R:V111 7.3 1 No No 7 7 1 2
R:R:V111 R:R:Y367 3.79 1 No Yes 7 8 2 1
R:R:V112 R:R:Y367 5.05 0 No Yes 7 8 2 1
R:R:F114 R:R:W124 5.01 1 No Yes 5 7 2 2
R:R:F114 R:R:W134 5.01 1 No Yes 5 5 2 1
R:R:G115 R:R:W134 4.22 0 No Yes 6 5 2 1
R:R:W124 R:R:W134 8.43 1 Yes Yes 7 5 2 1
R:R:T135 R:R:W134 3.64 0 No Yes 5 5 2 1
L:L:?1413 R:R:W134 6.72 1 Yes Yes 0 5 0 1
R:R:F218 R:R:T135 5.19 1 Yes No 6 5 1 2
R:R:D138 R:R:Y367 10.34 1 No Yes 7 8 1 1
L:L:?1413 R:R:D138 14.24 1 Yes No 0 7 0 1
L:L:?1413 R:R:V139 16.61 1 Yes No 0 7 0 1
R:R:S232 R:R:T143 9.59 0 No Yes 7 7 1 2
R:R:I194 R:R:W199 9.4 1 Yes Yes 6 6 2 2
R:R:F218 R:R:I194 5.02 1 Yes Yes 6 6 1 2
R:R:I194 R:R:Y224 3.63 1 Yes Yes 6 7 2 2
R:R:F218 R:R:W199 9.02 1 Yes Yes 6 6 1 2
R:R:T220 R:R:W199 6.06 1 Yes Yes 5 6 2 2
R:R:W199 R:R:Y224 6.75 1 Yes Yes 6 7 2 2
R:R:F218 R:R:T220 7.78 1 Yes Yes 6 5 1 2
R:R:F218 R:R:Y224 6.19 1 Yes Yes 6 7 1 2
L:L:?1413 R:R:F218 10.38 1 Yes Yes 0 6 0 1
R:R:T220 R:R:Y224 3.75 1 Yes Yes 5 7 2 2
R:R:S228 R:R:Y224 10.17 0 No Yes 6 7 1 2
L:L:?1413 R:R:S228 7.88 1 Yes No 0 6 0 1
R:R:F341 R:R:S229 5.28 0 Yes No 7 7 2 2
R:R:N344 R:R:S229 5.96 0 No No 6 7 1 2
L:L:?1413 R:R:S232 3.94 1 Yes No 0 7 0 1
R:R:F340 R:R:F341 8.57 1 Yes Yes 7 7 1 2
R:R:F340 R:R:F359 9.65 1 Yes No 7 5 1 2
R:R:F340 R:R:N363 12.08 1 Yes No 7 6 1 1
L:L:?1413 R:R:F340 7.99 1 Yes Yes 0 7 0 1
L:L:?1413 R:R:N344 9.91 1 Yes No 0 6 0 1
L:L:?1413 R:R:V360 4.88 1 Yes No 0 5 0 1
R:R:N363 R:R:Y367 11.63 1 No Yes 6 8 1 1
L:L:?1413 R:R:N363 13.51 1 Yes No 0 6 0 1
R:R:W364 R:R:Y367 10.61 0 No Yes 7 8 2 1
L:L:?1413 R:R:Y367 4.61 1 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.15
Average Nodes In Shell28.00
Average Hubs In Shell13.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.71
Average Number Of Links With An Hub4.14
Average Interaction Strength9.49
Average Nodes In Shell27.43
Average Hubs In Shell13.00
Average Links In Shell38.71
Average Links Mediated by Hubs In Shell35.86

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)