Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.6941010
2R:R:N51 5.6775409
3R:R:L53 4.49406
4R:R:F61 10.146506
5R:R:F71 4.5508
6R:R:D79 6.994519
7R:R:M82 5.575407
8R:R:V86 4.25407
9R:R:W99 8.77537
10R:R:D130 6.0025408
11R:R:Y132 7.4975408
12R:R:F133 2.975405
13R:R:F166 5.276544
14R:R:Y174 7.1975405
15R:R:H178 3.9425452
16R:R:F194 4.465451
17R:R:Y199 6.248506
18R:R:F208 10.884518
19R:R:Y209 5.794515
20R:R:Y219 4.648519
21R:R:F223 4.712506
22R:R:F282 4.82167619
23R:R:W286 7.32857718
24R:R:L287 4.4025406
25R:R:F289 10.3067616
26R:R:F290 9.198517
27R:R:H296 6.1325413
28R:R:I303 4.988513
29R:R:W313 8.5275405
30R:R:Y316 8.37516
31R:R:N318 7.3475419
32R:R:N322 8.53419
33R:R:Y326 5.102519
34R:R:F332 6.29375829
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y316 34.92464.54YesYes106
2R:R:W313 R:R:Y316 23.714310.61YesYes056
3R:R:M82 R:R:Y316 31.69283.59YesYes076
4R:R:M82 R:R:S319 36.67657.67YesNo079
5R:R:D79 R:R:S319 36.622110.31YesNo099
6R:R:D79 R:R:N51 52.94448.08YesYes099
7R:R:N51 R:R:P323 41.91274.89YesNo099
8R:R:P323 R:R:V54 40.76683.53NoNo099
9R:R:C327 R:R:V54 36.10555.12NoNo079
10R:R:C327 R:R:F332 34.920813.97NoYes079
11R:R:F332 R:R:F336 10.72097.5YesNo297
12R:R:F332 R:R:L64 13.3744.87YesNo298
13R:R:F61 R:R:L64 12.17373.65YesNo068
14L:L:?1 R:R:V117 34.885810.1YesNo006
15R:R:V117 R:R:W286 34.88589.81NoYes068
16R:R:N318 R:R:W286 77.88226.78YesYes198
17R:R:N318 R:R:N322 90.79799.54YesYes199
18R:R:L124 R:R:N322 87.4349.61NoYes189
19R:R:L124 R:R:Y326 1005.86NoYes189
20R:R:I127 R:R:Y326 84.11286.04NoYes199
21R:R:F71 R:R:I127 82.24833.77YesNo089
22R:R:D130 R:R:F71 55.32947.17YesYes088
23L:L:?1 R:R:F289 47.203210.61YesYes106
24R:R:F289 R:R:W286 48.28317.02YesYes168
25L:L:?1 R:R:F290 52.7545.9YesYes107
26R:R:F290 R:R:W286 36.8287.02YesYes178
27R:R:F71 R:R:I154 13.74695.02YesNo088
28R:R:I154 R:R:S74 11.47456.19NoNo089
29R:R:D79 R:R:L75 15.0215.43YesNo199
30L:L:?1 R:R:D113 13.016618.4YesNo107
31R:R:D113 R:R:V86 12.83795.84NoYes077
32R:R:V86 R:R:W109 16.62524.9YesNo075
33R:R:W109 R:R:W99 13.45176.56NoYes057
34R:R:I94 R:R:W313 11.02784.7NoYes055
35L:L:?1 R:R:V114 55.838210.1YesNo005
36R:R:V114 R:R:Y199 54.48653.79NoYes056
37R:R:Y174 R:R:Y199 90.12593.97YesYes056
38R:R:I169 R:R:Y174 30.943110.88NoYes055
39R:R:I169 R:R:S111 27.91334.64NoNo056
40R:R:F166 R:R:S111 24.918413.21YesNo046
41R:R:F108 R:R:F166 22.74323.22NoYes054
42R:R:F108 R:R:W105 13.71196.01NoNo055
43L:L:?1 R:R:S203 61.773610.18YesNo005
44R:R:S203 R:R:Y199 55.318.9NoYes056
45L:L:?1 R:R:S207 27.47055.82YesNo005
46R:R:S207 R:R:T118 25.83517.99NoNo056
47R:R:S161 R:R:T118 18.1137.99NoNo086
48R:R:G162 R:R:S161 16.52041.86NoNo048
49R:R:G162 R:R:S165 15.10251.86NoNo047
50R:R:F166 R:R:S165 12.24753.96YesNo447
51R:R:F282 R:R:W286 32.4934.01YesYes198
52R:R:F208 R:R:F290 16.108617.15YesYes187
53R:R:F208 R:R:F282 17.38666.43YesYes189
54R:R:I121 R:R:W286 10.60058.22NoYes178
55R:R:I121 R:R:P211 10.57723.39NoNo078
56R:R:F282 R:R:M215 48.43464.98YesNo198
57R:R:M215 R:R:Y219 40.35893.59NoYes189
58R:R:D130 R:R:L145 46.78372.71YesNo087
59R:R:L144 R:R:L145 44.62796.92NoNo047
60R:R:F133 R:R:L144 42.46434.87YesNo054
61R:R:F133 R:R:Y132 27.10153.09YesYes058
62R:R:T136 R:R:Y132 15.89514.98NoYes078
63R:R:E225 R:R:T136 13.626514.11NoNo057
64R:R:F133 R:R:S137 11.47451.32YesNo056
65R:R:P168 R:R:Y199 18.80448.34NoYes056
66R:R:L167 R:R:P168 15.68914.93NoNo055
67R:R:Y174 R:R:Y185 52.40064.96YesNo051
68R:R:A181 R:R:Y185 46.43412.67NoNo041
69R:R:A181 R:R:H178 15.49494.39NoYes542
70R:R:A181 R:R:F194 27.89394.16NoYes541
71R:R:C184 R:R:F194 21.88475.59NoYes011
72R:R:F208 R:R:L287 10.28988.53YesYes086
73R:R:L275 R:R:Y219 21.81094.69NoYes089
74R:R:I278 R:R:Y219 13.61873.63NoYes089
75R:R:F223 R:R:L275 19.08793.65YesNo068
76R:R:I278 R:R:T274 10.87241.52NoNo088
77R:R:I325 R:R:Y326 11.47454.84NoYes089
78R:R:F289 R:R:N293 13.39348.46YesNo165
79R:R:F289 R:R:Y308 13.39348.25YesNo165
80R:R:H296 R:R:N293 12.31353.83YesNo135
81R:R:H296 R:R:I303 15.77453.98YesYes133
82R:R:H296 R:R:Y308 12.31359.8YesNo135
83R:R:C184 R:R:C190 18.78111.82NoNo013
84R:R:D79 R:R:N322 29.46326.73YesYes199
85R:R:L124 R:R:L75 14.50825.54NoNo189
86R:R:F282 R:R:N318 15.7943.62YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D113 18.4 1 Yes No 0 7 0 1
L:L:?1 R:R:V114 10.1 1 Yes No 0 5 0 1
L:L:?1 R:R:V117 10.1 1 Yes No 0 6 0 1
L:L:?1 R:R:F193 15.33 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 10.18 1 Yes No 0 5 0 1
L:L:?1 R:R:S207 5.82 1 Yes No 0 5 0 1
L:L:?1 R:R:F289 10.61 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N312 15.96 1 Yes No 0 5 0 1
L:L:?1 R:R:Y316 4.54 1 Yes Yes 0 6 0 1
R:R:M82 R:R:V86 4.56 0 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 3.59 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 5.84 1 No Yes 7 7 1 2
R:R:D113 R:R:Y316 12.64 1 No Yes 7 6 1 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 11.67 0 No No 4 3 1 2
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
R:R:F208 R:R:Y209 11.35 1 Yes Yes 8 5 2 2
R:R:F208 R:R:F290 17.15 1 Yes Yes 8 7 2 1
R:R:F290 R:R:Y209 4.13 1 Yes Yes 7 5 1 2
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 11.79 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 8.46 1 Yes No 6 5 1 2
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 1 Yes No 6 5 1 1
R:R:N293 R:R:Y308 10.47 1 No No 5 5 2 2
R:R:N312 R:R:Y316 10.47 1 No Yes 5 6 1 1
R:R:W313 R:R:Y316 10.61 0 Yes Yes 5 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8GE5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.53
Number of Linked Nodes 263
Number of Links 292
Number of Hubs 34
Number of Links mediated by Hubs 142
Number of Communities 5
Number of Nodes involved in Communities 46
Number of Links involved in Communities 65
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 67387
Length Of Smallest Path 3
Average Path Length 13.61
Length of Longest Path 30
Minimum Path Strength 1.38
Average Path Strength 6.38905
Maximum Path Strength 17.975
Minimum Path Correlation 0.7
Average Path Correlation 0.935381
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 53.9563
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.915
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• amyloid-beta binding   • binding   • peptide binding   • protein binding   • enzyme binding   • adenylate cyclase binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • beta2-adrenergic receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • beta-adrenergic receptor activity   • adrenergic receptor activity   • protein-containing complex binding   • potassium channel regulator activity   • channel regulator activity   • ion channel regulator activity   • molecular function regulator activity   • transporter regulator activity   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • cation binding   • ion binding   • catecholamine binding   • norepinephrine binding   • small molecule binding   • multicellular organismal process   • response to nutrient levels   • multicellular organismal-level homeostasis   • response to stimulus   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus
Gene OntologyBiological Process• multicellular organismal process   • response to nutrient levels   • multicellular organismal-level homeostasis   • response to stimulus   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • biological regulation   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting adrenergic receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • adrenergic receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of developmental process   • positive regulation of biological process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • multicellular organism development   • positive regulation of biomineral tissue development   • ossification   • anatomical structure development   • biomineral tissue development   • regulation of multicellular organismal process   • developmental process   • regulation of multicellular organismal development   • bone mineralization   • animal organ development   • tissue development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • negative regulation of multicellular organism growth   • developmental growth   • negative regulation of developmental process   • growth   • negative regulation of biological process   • multicellular organism growth   • negative regulation of developmental growth   • negative regulation of growth   • negative regulation of multicellular organismal process   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • fat cell differentiation   • cellular developmental process   • brown fat cell differentiation   • cell differentiation   • negative regulation of cardiac muscle cell apoptotic process   • muscle cell apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of cardiac muscle cell apoptotic process   • regulation of muscle cell apoptotic process   • regulation of programmed cell death   • cell death   • cardiac muscle cell apoptotic process   • negative regulation of apoptotic process   • regulation of striated muscle cell apoptotic process   • striated muscle cell apoptotic process   • negative regulation of muscle cell apoptotic process   • negative regulation of cellular process   • negative regulation of striated muscle cell apoptotic process   • apoptotic process   • programmed cell death   • system process   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • negative regulation of muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • negative regulation of smooth muscle contraction   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • positive regulation of cellular process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • localization   • import into cell   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • cellular localization   • endosome to lysosome transport   • intracellular transport   • lysosomal transport   • establishment of localization in cell   • vacuolar transport   • heart process   • regulation of actin filament-based process   • regulation of heart contraction   • cardiac muscle contraction   • striated muscle contraction   • circulatory system process   • actin filament-based process   • positive regulation of actin filament-based movement   • blood circulation   • cardiac muscle cell contraction   • regulation of cardiac muscle contraction   • positive regulation of cardiac muscle cell contraction   • actin filament-based movement   • regulation of blood circulation   • regulation of striated muscle contraction   • regulation of actin filament-based movement   • regulation of cardiac muscle cell contraction   • actin-mediated cell contraction   • heart contraction   • positive regulation of organelle organization   • catabolic process   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of autophagosome maturation   • macroautophagy   • autophagy   • protein-containing complex disassembly   • regulation of autophagy   • regulation of protein-containing complex disassembly   • cellular component organization   • autophagosome maturation   • cellular component organization or biogenesis   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • positive regulation of protein-containing complex disassembly   • cellular component disassembly   • positive regulation of autophagy   • protein-containing complex organization   • regulation of catabolic process   • positive regulation of autophagosome maturation   • regulation of organelle organization   • positive regulation of catabolic process   • organelle organization   • regulation of macroautophagy   • positive regulation of cardiac muscle cell apoptotic process   • positive regulation of programmed cell death   • positive regulation of striated muscle cell apoptotic process   • positive regulation of apoptotic process   • positive regulation of muscle cell apoptotic process   • lipophagy   • positive regulation of lipophagy   • regulation of lipophagy   • response to psychosocial stress   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • positive regulation of cold-induced thermogenesis   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • positive regulation of signaling   • cell surface receptor signaling pathway   • ligand-gated ion channel signaling pathway   • ionotropic glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • AMPA selective glutamate receptor signaling pathway   • regulation of tube diameter   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of tube size   • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure   • negative regulation of blood pressure   • regulation of systemic arterial blood pressure by norepinephrine-epinephrine   • regulation of systemic arterial blood pressure   • negative regulation of systemic arterial blood pressure   • vascular process in circulatory system   • regulation of biological quality   • blood vessel diameter maintenance   • vasodilation   • regulation of anatomical structure size   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • cellular response to nitrogen compound   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to amyloid-beta   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • response to amyloid-beta   • regulation of localization   • regulation of transport   • regulation of monoatomic ion transport   • regulation of sodium ion transport   • metal ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • sodium ion transport   • heat generation   • regulation of postsynaptic membrane potential   • modulation of chemical synaptic transmission   • positive regulation of excitatory postsynaptic potential   • chemical synaptic transmission, postsynaptic   • synaptic signaling   • modulation of excitatory postsynaptic potential   • mini excitatory postsynaptic potential   • trans-synaptic signaling   • nervous system process   • cell-cell signaling   • chemical synaptic transmission   • regulation of nervous system process   • regulation of mini excitatory postsynaptic potential   • positive regulation of mini excitatory postsynaptic potential   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • excitatory postsynaptic potential   • regulation of membrane potential   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • bounding membrane of organelle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • organelle membrane   • protein-containing complex   • receptor complex   • intercellular bridge   • Golgi apparatus   • endosome membrane   • endosome   • intracellular membraneless organelle   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • microtubule cytoskeleton   • cell periphery   • apical part of cell   • plasma membrane   • plasma membrane region   • apical plasma membrane   • mitotic spindle   • spindle   • lytic vacuole   • vacuole   • lysosome   • early endosome   • nucleus   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole membrane   • lysosomal membrane   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier
FormulaC11 H15 N O3
Molecular Weight209.242
SMILES
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GE5_nogp_Chain_R
EVWVVGMGI VMSLIVLAI VFGNVLVIT AIAKFERLQ TVTNYFITS 
LACADLVMG LAVVPFGAA HILTKTWTF GNFWCEFWT SIDVLCVTA 
SIETLCVIA VDRYFAITS PFKYQSLLT KNKARVIIL MVWIVSGLT 
SFLPIQMHW YRATHQEAI NCYAEETCC DFFTNQAYA IASSIVSFY 
VPLVIMVFV YSRVFQEAK RQLQKIDKS EGRFHVHKA LKTLGIIMG 
TFTLCWLPF FIVNIVHVI QDNLIRKEV YILLNWIGY VNSGFNPLI 
YCRSPDFRI AFQELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2RH1AAmineAdrenergicβ2Homo sapiensCarazolol--2.42007-10-30doi.org/10.1126/science.1150577
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-17doi.org/10.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-16doi.org/10.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-11doi.org/10.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiensAlprenolol--3.162010-08-11doi.org/10.1021/ja105108q
3PDSAAmineAdrenergicβ2Homo sapiensFAUC50--3.52011-01-12doi.org/10.1038/nature09665
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-19doi.org/10.1038/nature09648
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
3SN6 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.22011-07-20doi.org/10.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiensCarazolol--3.992012-10-24doi.org/10.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-25doi.org/10.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzyl Isoproterenol--3.12013-09-25doi.org/10.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22013-09-25doi.org/10.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-23doi.org/10.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiensCarazolol--2.482016-01-13doi.org/10.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiensCarazolol--3.82016-01-13doi.org/10.1107/S2059798315021683
5JQHAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-07-13doi.org/10.1038/nature18636
5D6LAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-08-17doi.org/10.1038/nprot.2017.057
5X7DAAmineAdrenergicβ2Homo sapiensCarazololPubChem 129318963-2.72017-08-16doi.org/10.1038/nature23652
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-14doi.org/10.1038/s41589-018-0145-x
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6E67 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-26doi.org/10.1126/science.aaw8981
6PRZAAmineAdrenergicβ2Homo sapiensAlprenolol--2.82019-11-13doi.org/10.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensCarazolol--3.42019-11-13doi.org/10.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-13doi.org/10.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensAlprenolol--2.42019-11-13doi.org/10.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensCarvedilol--2.52019-11-13doi.org/10.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-13doi.org/10.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensPropranolol--2.92019-11-13doi.org/10.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-13doi.org/10.1107/S2052252519013137
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6NI3 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.82019-11-20doi.org/10.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiensAlprenololGTPL11074-3.12020-03-25doi.org/10.1038/s41589-020-0549-2
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
7BZ2 (No Gprot) AAmineAdrenergicβ2Homo sapiensArformoterol-3.822020-08-05doi.org/10.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHI (No Gprot) AAmineAdrenergicβ2Homo sapiensSalbutamol-3.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7DHR (No Gprot) AAmineAdrenergicβ2Homo sapiensIsoprenaline-3.82020-12-16doi.org/10.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-26doi.org/10.1038/s41467-023-37808-y
8JJ8AAmineAdrenergicβ2Homo sapiensArformoterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-06doi.org/10.1038/s41589-023-01389-0
8GE2AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.22024-03-06doi.org/10.1038/s41586-024-07153-1
9CHUAAmineAdrenergicβ2Homo sapiensNorepinephrine--3.492024-11-13doi.org/10.1073/pnas.2414544121
9CHVAAmineAdrenergicβ2Homo sapiens---3.952024-11-13doi.org/10.1073/pnas.2414544121
9U9VAAmineAdrenergicβ2Homo sapiensMETH-Gs/β1/γ22.852025-09-03To be published
9U9V (No Gprot) AAmineAdrenergicβ2Homo sapiensMETH-2.852025-09-03To be published
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GDZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GEB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GED (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEG (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEH (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-42024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEI (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP2.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-06doi.org/10.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNL (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNM (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNN (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNO (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNP (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNR (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNS (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNT (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNU (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg42024-03-06doi.org/10.1038/s41586-024-07153-1
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
9CHXAAmineAdrenergicβ2Homo sapiensCarazolol--3.52024-11-13doi.org/10.1073/pnas.2414544121
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
9BUY (No Gprot) AAmineAdrenergicβ2Homo sapiensLM189-2.92025-05-28doi.org/10.1126/sciadv.adq3971
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M55 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-3.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9M57 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-3.652025-12-1710.1093/pnasnexus/pgaf376
9L8LAAmineAdrenergicβ2Homo sapiensBI167107AtazanavirGs/β1/γ2 ; Arrestin23.222025-12-31To be published
9L8L (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107Atazanavir3.222025-12-31To be published




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