CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6
Networks79
 missing image

This ligand is also present in the following 79 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XKA A Amine Adrenergic Beta2 Homo Sapiens Epinephrine - - 3.1 2023-04-26  10.1038/s41467-023-37808-y

A 2D representation of the interactions of G1I in 7XKA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 6.09 1 No No 7 7 2 2
R:R:M82 R:R:Y316 5.99 1 No Yes 7 6 2 1
R:R:D113 R:R:V86 5.84 1 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 18.61 1 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 12.02 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 9.08 1 No No 4 3 1 2
R:R:F193 R:R:Y308 6.19 1 No Yes 4 5 1 1
L:L:?1 R:R:F193 10.81 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 7.49 1 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 1 Yes Yes 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes Yes 5 5 1 2
L:L:?1 R:R:S207 6.06 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 22.51 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 9.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 12.86 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 9.67 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 12.38 1 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 19.33 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:V292 R:R:Y308 5.05 0 No Yes 5 5 2 1
R:R:H296 R:R:N293 5.1 1 No Yes 3 5 2 1
R:R:N293 R:R:Y308 9.3 1 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 5.54 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 14.16 1 No Yes 3 5 2 1
L:L:?1 R:R:Y308 3.78 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 12.79 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 16.62 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 6.62 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.47
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDZ A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GDZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 4.38 2 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 2 Yes Yes 7 6 2 2
R:R:D113 R:R:Y316 12.64 2 No Yes 7 6 1 2
L:L:?1 R:R:D113 14.23 2 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 9.62 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 2 No No 5 6 1 2
R:R:F193 R:R:Y174 4.13 0 No Yes 4 5 1 2
R:R:Y174 R:R:Y199 6.95 9 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 6.49 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 12.77 2 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 0 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 10.17 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 7.93 2 Yes No 7 5 1 2
R:R:F290 R:R:S207 5.28 2 Yes No 7 5 1 1
L:L:?1 R:R:S207 6.06 2 Yes No 0 5 0 1
R:R:F208 R:R:F290 19.29 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 2 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 9.28 2 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 13.29 2 Yes Yes 6 5 1 1
L:L:?1 R:R:F289 9.83 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 2 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 7.65 2 Yes No 3 5 2 2
R:R:N293 R:R:Y308 3.49 2 No Yes 5 5 2 1
R:R:H296 R:R:Y308 7.62 2 Yes Yes 3 5 2 1
R:R:N312 R:R:Y308 3.49 2 Yes Yes 5 5 1 1
L:L:?1 R:R:Y308 3.78 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 10.47 2 Yes Yes 5 6 1 2
L:L:?1 R:R:N312 13.29 2 Yes Yes 0 5 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.24
Average Nodes In Shell22.00
Average Hubs In Shell13.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE1 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:Y316 4.79 0 No Yes 7 6 2 1
R:R:D113 R:R:V86 14.61 5 No No 7 7 1 2
R:R:V86 R:R:Y316 5.05 5 No Yes 7 6 2 1
R:R:V87 R:R:W313 4.9 5 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 3.79 5 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 12.64 5 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 5 Yes No 0 7 0 1
R:R:S165 R:R:V114 8.08 0 No No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 8.41 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 5 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 5 No No 5 6 1 2
R:R:S203 R:R:T164 3.2 0 No No 5 5 1 2
R:R:F193 R:R:Y174 4.13 0 No Yes 4 5 1 2
R:R:Y174 R:R:Y199 4.96 9 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 12.77 5 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 9 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 5 Yes No 0 5 0 1
R:R:F290 R:R:S204 7.93 5 Yes No 7 5 1 2
R:R:F290 R:R:S207 5.28 5 Yes No 7 5 1 1
L:L:?1 R:R:S207 6.06 5 Yes No 0 5 0 1
R:R:F208 R:R:F290 19.29 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 8.02 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 11.79 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 5 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 5 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 17.44 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 9.65 5 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 5 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.65
Average Nodes In Shell25.00
Average Hubs In Shell11.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE3 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 4 No Yes 7 7 1 2
R:R:D113 R:R:Y316 12.64 4 No Yes 7 6 1 1
L:L:?1 R:R:D113 15.33 4 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 21 Yes No 7 5 2 1
L:L:?1 R:R:V114 4.81 4 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 4 Yes No 7 6 2 1
R:R:V117 R:R:W286 9.81 4 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 4 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No Yes 5 6 1 2
R:R:I121 R:R:W286 8.22 4 Yes Yes 7 8 2 2
R:R:F193 R:R:T195 10.38 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 10.9 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 4 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 4 Yes No 5 5 1 2
L:L:?1 R:R:S207 4.85 4 Yes No 0 5 0 1
R:R:F208 R:R:Y209 6.19 4 Yes No 8 5 2 2
R:R:F208 R:R:F290 20.36 4 Yes Yes 8 7 2 1
R:R:F290 R:R:Y209 3.09 4 Yes No 7 5 1 2
R:R:F289 R:R:W286 7.02 4 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 4 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 4 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 7.22 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 14.5 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 4 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 4 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 10.47 4 Yes No 5 5 1 2
L:L:?1 R:R:N293 3.32 4 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 17.42 4 Yes No 3 5 2 2
R:R:N312 R:R:Y316 12.79 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 9.65 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 4 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.55
Average Nodes In Shell25.00
Average Hubs In Shell13.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE4 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 4.56 0 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 3.59 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 4.38 4 No Yes 7 7 1 2
R:R:D113 R:R:Y316 12.64 4 No Yes 7 6 1 1
L:L:?1 R:R:D113 14.23 4 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 8.41 4 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 4 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No No 5 6 1 2
R:R:F193 R:R:Y174 4.13 0 No Yes 4 5 1 2
R:R:Y174 R:R:Y199 4.96 0 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 4 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 4 Yes No 5 5 2 2
L:L:?1 R:R:S207 4.85 4 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 8.02 4 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 4 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 4 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 4 Yes Yes 6 5 1 2
R:R:F289 R:R:Y308 8.25 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 4 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 10.47 4 Yes No 5 5 2 2
R:R:N312 R:R:Y316 12.79 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 4 Yes Yes 0 6 0 1
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.65
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE6 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 7.61 5 No Yes 7 7 2 2
R:R:M82 R:R:Y316 3.59 5 No Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 5 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 5 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 3.68 5 No Yes 7 5 2 2
R:R:V87 R:R:Y316 3.79 5 No Yes 7 6 2 1
R:R:D113 R:R:Y316 12.64 5 No Yes 7 6 1 1
L:L:?1 R:R:D113 15.33 5 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 6.01 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 5 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 10.38 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 5 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 5 Yes No 0 5 0 1
L:L:?1 R:R:S207 3.63 5 Yes No 0 5 0 1
R:R:F208 R:R:F290 15 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 5 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 5 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 12.79 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 5 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 5 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.72
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE7 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 9 No Yes 7 7 1 2
R:R:F193 R:R:T110 3.89 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 13.79 9 No Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 9 Yes No 0 7 0 1
L:L:?1 R:R:V114 10.82 9 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 9 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 10.38 0 Yes No 4 3 1 2
R:R:F193 R:R:Y308 4.13 0 Yes No 4 5 1 2
L:L:?1 R:R:F193 11.79 9 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 4.99 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 9 Yes No 0 5 0 1
L:L:?1 R:R:S207 6.06 9 Yes No 0 5 0 1
R:R:F208 R:R:F290 19.29 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 9 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 9 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 9 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 9 Yes No 6 5 1 2
R:R:F289 R:R:N312 16.92 9 Yes No 6 5 1 1
L:L:?1 R:R:F289 12.77 9 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 9 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 13.96 9 No Yes 5 6 1 1
L:L:?1 R:R:N312 15.51 9 Yes No 0 5 0 1
R:R:W313 R:R:Y316 10.61 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 6.62 9 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.07
Average Nodes In Shell20.00
Average Hubs In Shell10.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE8 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 11.69 3 No Yes 7 7 1 2
R:R:F193 R:R:T110 3.89 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 12.64 3 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 3 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 10 Yes No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 4.81 3 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 3 Yes Yes 7 6 2 1
R:R:V117 R:R:W286 9.81 3 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 3 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:I121 R:R:W286 9.4 3 Yes Yes 7 8 2 2
R:R:F193 R:R:Y174 3.09 0 Yes Yes 4 5 1 2
R:R:Y174 R:R:Y199 3.97 10 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 0 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 4.13 0 Yes No 4 5 1 2
L:L:?1 R:R:F193 12.77 3 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 3 Yes No 0 5 0 1
L:L:?1 R:R:S207 6.06 3 Yes No 0 5 0 1
R:R:F208 R:R:Y209 11.35 3 Yes Yes 8 5 2 2
R:R:F208 R:R:F290 19.29 3 Yes Yes 8 7 2 1
R:R:F290 R:R:Y209 3.09 3 Yes Yes 7 5 1 2
R:R:F289 R:R:W286 6.01 3 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 8.02 3 Yes Yes 7 8 1 2
R:R:F289 R:R:N293 14.5 3 Yes No 6 5 1 2
R:R:F289 R:R:Y308 9.28 3 Yes No 6 5 1 2
R:R:F289 R:R:N312 18.12 3 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 3 Yes Yes 0 6 0 1
R:R:F290 R:R:N293 4.83 3 Yes No 7 5 1 2
L:L:?1 R:R:F290 5.9 3 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 9.3 3 No No 5 5 2 2
R:R:N312 R:R:Y316 12.79 3 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 3 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 4.73 3 Yes Yes 0 6 0 1
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.61
Average Nodes In Shell27.00
Average Hubs In Shell17.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GE9 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GE9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 11.69 7 No No 7 7 1 2
R:R:D113 R:R:Y316 12.64 7 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 7 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 9.62 7 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 7 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:Y174 4.13 0 Yes Yes 4 5 1 2
R:R:Y174 R:R:Y199 3.97 8 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 10.81 7 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 7 Yes No 0 5 0 1
L:L:?1 R:R:S207 3.63 7 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 7 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 8.02 7 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 7 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 7 Yes No 6 5 1 2
R:R:F289 R:R:L311 3.65 7 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 7 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 7 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 7 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 17.44 7 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 7 Yes No 0 5 0 1
R:R:W313 R:R:Y316 12.54 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 7 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.40
Average Nodes In Shell24.00
Average Hubs In Shell10.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEA A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 2 No No 7 7 1 2
R:R:V87 R:R:Y316 3.79 0 No Yes 7 6 2 1
R:R:D113 R:R:Y316 12.64 2 No Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 2 Yes No 0 7 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 0 Yes No 4 3 1 2
R:R:F193 R:R:Y308 4.13 0 Yes Yes 4 5 1 2
L:L:?1 R:R:F193 10.81 2 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 2 Yes No 0 5 0 1
L:L:?1 R:R:S207 3.63 2 Yes No 0 5 0 1
R:R:F208 R:R:F290 19.29 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 9.02 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 2 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 9.28 2 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 13.29 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 2 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 15.12 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 14.4 2 Yes No 0 5 0 1
R:R:W313 R:R:Y316 12.54 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 2 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.00
Average Nodes In Shell20.00
Average Hubs In Shell9.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEB A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 11.69 1 No Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
R:R:D113 R:R:Y316 13.79 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 16.42 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 1 Yes Yes 7 5 2 1
R:R:I169 R:R:V114 3.07 1 Yes Yes 5 5 2 1
R:R:V114 R:R:Y199 3.79 1 Yes Yes 5 6 1 2
L:L:?1 R:R:V114 7.21 1 Yes Yes 0 5 0 1
R:R:I121 R:R:V117 3.07 1 Yes Yes 7 6 2 1
R:R:V117 R:R:W286 9.81 1 Yes Yes 6 8 1 2
R:R:F290 R:R:V117 2.62 1 Yes Yes 7 6 1 1
L:L:?1 R:R:V117 7.21 1 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No No 5 6 1 2
R:R:F208 R:R:I121 2.51 1 Yes Yes 8 7 2 2
R:R:I121 R:R:W286 10.57 1 Yes Yes 7 8 2 2
R:R:F290 R:R:I121 2.51 1 Yes Yes 7 7 1 2
R:R:I169 R:R:Y199 2.42 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 1 Yes No 4 3 1 2
R:R:F193 R:R:Y308 5.16 1 Yes Yes 4 5 1 1
L:L:?1 R:R:F193 9.83 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 No No 5 5 2 2
R:R:F290 R:R:S207 5.28 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 3.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 1 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 3.65 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 10.87 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 1 Yes No 3 5 2 2
R:R:N293 R:R:Y308 3.49 1 No Yes 5 5 2 1
R:R:H296 R:R:Y308 8.71 1 Yes Yes 3 5 2 1
R:R:I309 R:R:Y308 2.42 0 No Yes 3 5 2 1
L:L:?1 R:R:Y308 5.67 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 17.44 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.40
Average Nodes In Shell28.00
Average Hubs In Shell18.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEC A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 8.76 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 1
R:R:V87 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 16.42 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 36 No No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 9.62 1 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 1 Yes No 7 6 2 1
R:R:V117 R:R:W286 9.81 1 No Yes 6 8 1 2
L:L:?1 R:R:V117 6.01 1 Yes No 0 6 0 1
R:R:I121 R:R:W286 10.57 1 Yes Yes 7 8 2 2
R:R:F193 R:R:T195 9.08 0 No No 4 3 1 2
L:L:?1 R:R:F193 9.83 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:F290 R:R:S207 6.61 1 Yes No 7 5 1 2
R:R:F208 R:R:F290 18.22 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 8.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 1 Yes No 6 5 1 2
R:R:F289 R:R:L311 3.65 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 12.79 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 5.79 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.30
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GED A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GED
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 11.69 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 15.14 1 Yes Yes 7 6 2 2
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 13.14 1 Yes No 0 7 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 1 Yes No 5 6 1 2
R:R:I121 R:R:S207 3.1 1 Yes Yes 7 5 2 1
R:R:I121 R:R:W286 7.05 1 Yes Yes 7 8 2 2
R:R:F193 R:R:T195 11.67 0 No No 4 3 1 2
R:R:F193 R:R:Y308 6.19 0 No Yes 4 5 1 2
L:L:?1 R:R:F193 15.72 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 35 No Yes 3 6 2 2
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
R:R:A200 R:R:N293 3.13 0 No Yes 5 5 2 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S207 5.28 1 Yes Yes 7 5 1 1
L:L:?1 R:R:S207 3.63 1 Yes Yes 0 5 0 1
R:R:F208 R:R:F290 20.36 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 8.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 7.22 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 7.65 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 5.81 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 5.54 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 13.07 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 6.98 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.41
Average Nodes In Shell21.00
Average Hubs In Shell13.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEE A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.7 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:M82 R:R:Y316 5.99 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 4.38 2 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 2 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 11.49 2 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 2 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 2 Yes No 7 5 2 1
R:R:I169 R:R:V114 3.07 0 No No 5 5 2 1
L:L:?1 R:R:V114 6.01 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 8.58 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 4.8 2 No No 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 14.74 2 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No No 3 6 2 2
R:R:S203 R:R:Y199 13.99 0 No No 5 6 1 2
L:L:?1 R:R:S203 7.27 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 7.93 2 Yes No 7 5 1 2
R:R:F290 R:R:S207 5.28 2 Yes No 7 5 1 1
L:L:?1 R:R:S207 6.06 2 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 2 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 6.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 2 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 2 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 6.19 2 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 2 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 7.65 2 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 9.3 2 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 2 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 15.24 2 Yes No 3 5 2 2
R:R:N312 R:R:Y316 12.79 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 2 Yes No 0 5 0 1
L:L:?1 R:R:Y316 3.78 2 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:W313 R:R:Y316 1.93 0 Yes Yes 5 6 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.03
Average Nodes In Shell26.00
Average Hubs In Shell12.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEF A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.8 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 13.15 5 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 5 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 10.34 5 No Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 5 Yes No 0 7 0 1
L:L:?1 R:R:V114 8.41 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 5 Yes No 0 6 0 1
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 13.76 5 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 11.45 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 5 Yes No 0 5 0 1
R:R:F290 R:R:S207 5.28 5 Yes No 7 5 1 2
R:R:F208 R:R:F290 16.08 5 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 3.01 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 5 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 18.12 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 5 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 11.63 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 9.65 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 5 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.28
Average Nodes In Shell18.00
Average Hubs In Shell9.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEG A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 3.8 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 4.56 0 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 5.99 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 13.15 1 No Yes 7 7 1 2
R:R:D113 R:R:Y316 13.79 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 Yes No 7 5 2 1
L:L:?1 R:R:V114 9.62 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:Y174 3.09 1 No Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 No Yes 3 5 2 2
R:R:Y174 R:R:Y199 3.97 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 9.08 1 No No 4 3 1 2
L:L:?1 R:R:F193 13.76 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 1 No Yes 3 6 2 2
R:R:S203 R:R:Y199 12.72 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S207 6.61 1 Yes No 7 5 1 2
R:R:F208 R:R:Y209 7.22 1 Yes Yes 8 5 2 2
R:R:F208 R:R:F290 16.08 1 Yes Yes 8 7 2 1
R:R:F290 R:R:Y209 3.09 1 Yes Yes 7 5 1 2
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 16.92 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 10.47 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 9.8 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 15.51 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.31
Average Nodes In Shell24.00
Average Hubs In Shell15.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEH A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 6.09 4 Yes Yes 7 7 2 2
R:R:M82 R:R:V87 3.04 4 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 8.38 4 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 10.22 4 No Yes 7 7 1 2
R:R:V86 R:R:Y316 2.52 4 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 3.68 4 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 3.79 4 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 12.64 4 No Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 4 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 7.21 4 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 4 Yes No 7 6 2 1
R:R:V117 R:R:W286 7.36 4 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 4 Yes No 0 6 0 1
R:R:F208 R:R:I121 2.51 4 Yes Yes 8 7 2 2
R:R:I121 R:R:W286 9.4 4 Yes Yes 7 8 2 2
R:R:F290 R:R:I121 2.51 4 Yes Yes 7 7 1 2
R:R:F193 R:R:T195 11.67 0 No No 4 3 1 2
L:L:?1 R:R:F193 11.79 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 12.72 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 3.63 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 2.64 4 Yes No 7 5 1 2
R:R:F290 R:R:S207 7.93 4 Yes No 7 5 1 2
R:R:F208 R:R:F290 21.43 4 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 5.01 4 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 3.22 4 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 4 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 9.28 4 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 3.65 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 4 Yes Yes 0 6 0 1
R:R:F290 R:R:N293 3.62 4 Yes Yes 7 5 1 1
L:L:?1 R:R:F290 2.95 4 Yes Yes 0 7 0 1
R:R:V292 R:R:Y308 2.52 0 Yes Yes 5 5 2 1
R:R:L311 R:R:V292 2.98 0 No Yes 5 5 2 2
R:R:H296 R:R:N293 6.38 4 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 9.3 4 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 8.86 4 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 15.24 4 Yes Yes 3 5 2 1
L:L:?1 R:R:Y308 4.73 4 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 18.61 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 4 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 4 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.85
Average Nodes In Shell27.00
Average Hubs In Shell16.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEI A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 4.1 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C116 R:R:M82 8.1 1 Yes No 7 7 2 2
R:R:M82 R:R:Y316 3.59 0 No Yes 7 6 2 1
R:R:D113 R:R:V86 14.61 1 Yes Yes 7 7 1 2
R:R:C116 R:R:V86 5.12 1 Yes Yes 7 7 2 2
R:R:C116 R:R:D113 4.67 1 Yes Yes 7 7 2 1
R:R:D113 R:R:V117 2.92 1 Yes No 7 6 1 1
R:R:D113 R:R:Y316 8.05 1 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 1 Yes Yes 0 7 0 1
R:R:V117 R:R:W286 4.9 1 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:Y308 4.13 0 No Yes 4 5 1 2
L:L:?1 R:R:F193 12.77 1 Yes No 0 4 0 1
R:R:S203 R:R:Y199 12.72 0 No Yes 5 6 1 2
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 9.02 1 Yes Yes 7 8 2 2
R:R:F289 R:R:F290 11.79 1 Yes Yes 6 7 1 2
R:R:F289 R:R:N312 7.25 1 Yes Yes 6 5 1 1
L:L:?1 R:R:F289 8.84 1 Yes Yes 0 6 0 1
R:R:N312 R:R:W313 3.39 1 Yes Yes 5 5 1 2
R:R:N312 R:R:Y316 12.79 1 Yes Yes 5 6 1 1
L:L:?1 R:R:N312 16.62 1 Yes Yes 0 5 0 1
R:R:W313 R:R:Y316 6.75 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 6.62 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S203 2.42 1 Yes No 0 5 0 1
L:L:?1 R:R:V114 2.4 1 Yes No 0 5 0 1
R:R:S203 R:R:V206 1.62 0 No No 5 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.48
Average Nodes In Shell18.00
Average Hubs In Shell12.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GEJ A Amine Adrenergic Beta2 Homo sapiens Epinephrine - Gs/Beta1/Gamma2 4.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GEJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 13.15 0 No No 7 7 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:C116 R:R:D113 4.67 0 No No 7 7 2 1
L:L:?1 R:R:D113 10.95 0 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 3.61 0 Yes No 0 5 0 1
R:R:V117 R:R:Y316 17.66 0 No Yes 6 6 1 2
L:L:?1 R:R:V117 7.21 0 Yes No 0 6 0 1
R:R:F193 R:R:T195 10.38 0 No No 4 3 1 2
L:L:?1 R:R:F193 10.81 0 Yes No 0 4 0 1
R:R:F289 R:R:N312 8.46 7 Yes No 6 5 2 1
R:R:F289 R:R:Y316 7.22 7 Yes Yes 6 6 2 2
L:L:?1 R:R:N312 7.75 0 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub0.00
Average Interaction Strength8.07
Average Nodes In Shell13.00
Average Hubs In Shell3.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell8.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFV A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.1 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GFV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 3 No Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 11.49 3 No Yes 7 6 1 1
L:L:?1 R:R:D113 8.76 3 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
R:R:V114 R:R:Y199 2.52 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 6.01 3 Yes No 0 5 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 3 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 3 No No 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 3 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 3 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 3 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 3 Yes No 5 5 2 2
R:R:F290 R:R:S207 2.64 3 Yes No 7 5 1 1
L:L:?1 R:R:S207 4.85 3 Yes No 0 5 0 1
R:R:F208 R:R:F290 19.29 3 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 3 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 3 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 3 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 3 Yes Yes 6 5 1 2
R:R:F289 R:R:Y308 9.28 3 Yes No 6 5 1 2
R:R:F289 R:R:N312 8.46 3 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 3 Yes Yes 0 6 0 1
R:R:F290 R:R:N293 2.42 3 Yes Yes 7 5 1 2
L:L:?1 R:R:F290 6.88 3 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 4.65 3 Yes No 5 5 2 2
R:R:N312 R:R:Y316 10.47 3 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 3 Yes No 0 5 0 1
R:R:W313 R:R:Y316 5.79 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 3 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.88
Average Nodes In Shell23.00
Average Hubs In Shell10.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFW A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GFW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V117 3.04 0 No No 7 6 2 1
R:R:D113 R:R:V86 8.76 1 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:D113 R:R:Y316 12.64 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 6.13 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 12.77 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 26 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 7.27 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 9.28 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 9.67 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 6.98 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 13.96 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.03
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFX A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GFX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 8.76 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
R:R:D113 R:R:Y316 12.64 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 1 No No 7 5 2 1
R:R:V114 R:R:Y199 2.52 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No Yes 5 6 1 2
R:R:F193 R:R:Y174 3.09 1 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 No Yes 3 5 2 2
R:R:Y174 R:R:Y199 4.96 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 6.49 1 Yes No 4 3 1 2
L:L:?1 R:R:F193 12.77 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 3.75 1 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 7.27 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 2.55 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 4.65 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 5.44 1 Yes No 3 5 2 2
R:R:N312 R:R:Y316 12.79 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.08
Average Nodes In Shell26.00
Average Hubs In Shell15.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFY A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GFY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 1 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:D113 R:R:V117 2.92 1 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 12.64 1 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 9.85 1 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 0 Yes No 7 5 2 1
L:L:?1 R:R:V114 3.61 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 1 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:Y174 4.13 1 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 6.24 1 No Yes 3 5 2 2
R:R:Y174 R:R:Y199 4.96 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 10.38 1 Yes No 4 3 1 2
L:L:?1 R:R:F193 9.83 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 3.75 1 No Yes 3 6 2 2
R:R:S203 R:R:Y199 10.17 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 7.27 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 10.72 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 8.14 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 7.62 1 Yes No 3 5 2 2
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.69
Average Nodes In Shell26.00
Average Hubs In Shell18.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFZ A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GFZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 5 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 5 Yes Yes 7 6 2 1
R:R:D113 R:R:V117 2.92 5 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 12.64 5 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 5 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 3.61 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 5 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 5 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:Y174 5.16 0 Yes No 4 5 1 2
R:R:Y174 R:R:Y199 6.95 7 No Yes 5 6 2 2
R:R:F193 R:R:T195 6.49 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 12.77 5 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 10.17 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 5 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 5 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 0 No No 5 5 1 2
L:L:?1 R:R:S207 7.27 5 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 5 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 20.36 5 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 5 Yes No 6 5 1 2
R:R:F289 R:R:N312 14.5 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 5 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 9.3 0 No No 5 5 1 2
L:L:?1 R:R:N293 4.43 5 Yes No 0 5 0 1
R:R:N312 R:R:Y316 12.79 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 3.86 5 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 5 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.95
Average Nodes In Shell25.00
Average Hubs In Shell14.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG0 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 2.9 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 6 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 6 Yes No 7 6 2 1
R:R:M82 R:R:Y316 4.79 6 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 6 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 6 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 10.34 6 No Yes 7 6 1 1
L:L:?1 R:R:D113 8.76 6 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 4.81 6 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 6 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 3.89 0 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 3.09 0 Yes Yes 4 5 1 2
L:L:?1 R:R:F193 11.79 6 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 11 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 10.17 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 6 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 6 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 0 No No 5 5 1 2
L:L:?1 R:R:S207 7.27 6 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 6 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 6 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 6 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 6 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 10.72 6 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 7.22 6 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 14.5 6 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 6 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 6 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 0 No Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 6 Yes No 0 5 0 1
R:R:N312 R:R:Y316 11.63 6 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 6 Yes No 0 5 0 1
R:R:W313 R:R:Y316 3.86 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 6 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.69
Average Nodes In Shell24.00
Average Hubs In Shell14.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG1 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 7.3 2 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 2 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 11.49 2 No Yes 7 6 1 1
L:L:?1 R:R:D113 9.85 2 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
R:R:I169 R:R:V114 3.07 5 Yes No 5 5 2 1
L:L:?1 R:R:V114 4.81 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:I169 R:R:Y199 3.63 5 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 5.19 0 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 3.09 0 Yes Yes 4 5 1 2
L:L:?1 R:R:F193 10.81 2 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 5 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 2 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 2 Yes No 5 5 1 2
L:L:?1 R:R:S207 7.27 2 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 2 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 18.22 2 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 2 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 2 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 13.29 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 2 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 8.93 2 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 5.81 2 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 2 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 9.8 2 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 11.63 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 2 Yes No 0 5 0 1
R:R:W313 R:R:Y316 4.82 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 2 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.71
Average Nodes In Shell26.00
Average Hubs In Shell15.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG2 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes No 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 4.38 5 Yes No 7 7 1 2
R:R:V86 R:R:Y316 5.05 5 No Yes 7 6 2 1
R:R:D113 R:R:V117 2.92 5 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 11.49 5 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 5 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 8.08 0 No No 7 5 2 1
L:L:?1 R:R:V114 4.81 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 5 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 5 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No No 4 3 1 2
L:L:?1 R:R:F193 11.79 5 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 5 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 5 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 5 Yes No 5 5 1 2
L:L:?1 R:R:S207 7.27 5 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 5 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 5 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 6.43 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 7.22 5 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 5 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 5 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 5 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 5 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 15.24 5 Yes No 3 5 2 2
R:R:N312 R:R:Y316 16.28 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 3.86 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 5 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.18
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG3 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.1 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 4 Yes No 7 7 2 2
R:R:M82 R:R:Y316 4.79 4 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 4 Yes No 7 7 1 2
R:R:V86 R:R:Y316 3.79 4 No Yes 7 6 2 1
R:R:D113 R:R:W109 6.7 4 Yes No 7 5 1 2
R:R:D113 R:R:Y316 5.75 4 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 4.38 4 Yes Yes 0 7 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 4 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 9.83 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 6 No Yes 3 6 2 2
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 4 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 4 Yes No 5 5 1 2
L:L:?1 R:R:S207 4.85 4 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 4 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 4 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 4 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 9.67 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 4 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 4 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 5.81 4 Yes No 5 5 1 2
L:L:?1 R:R:N293 3.32 4 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 9.8 4 Yes No 3 5 2 2
R:R:N312 R:R:Y316 12.79 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 4.82 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 4 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.86
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG4 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 3 Yes No 7 7 2 2
R:R:M82 R:R:Y316 3.59 3 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 3 Yes No 7 7 1 2
R:R:V86 R:R:Y316 3.79 3 No Yes 7 6 2 1
R:R:D113 R:R:W109 13.4 3 Yes No 7 5 1 2
R:R:D113 R:R:Y316 3.45 3 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 3.28 3 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 3.61 3 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 3 No No 7 6 2 1
R:R:V117 R:R:W286 4.9 3 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 3 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No No 5 6 1 2
R:R:I121 R:R:W286 7.05 3 No Yes 7 8 2 2
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 11.79 3 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 34 No Yes 3 6 2 2
R:R:S203 R:R:Y199 11.45 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 3 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 3 Yes No 7 5 1 2
L:L:?1 R:R:S207 4.85 3 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 3 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 3 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 3 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 10.72 3 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 5.16 3 Yes No 6 5 1 2
R:R:F289 R:R:N312 8.46 3 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 3 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 3 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 11.63 3 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 3 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 3 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.88
Average Nodes In Shell25.00
Average Hubs In Shell10.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG5 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 1 Yes No 7 7 2 2
R:R:M82 R:R:Y316 3.59 1 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 1 No No 7 7 2 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:D113 R:R:Y316 3.45 1 No Yes 7 6 2 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
R:R:I169 R:R:V114 3.07 0 Yes No 5 5 2 1
L:L:?1 R:R:V114 6.01 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No No 4 3 1 2
L:L:?1 R:R:F193 8.84 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 11 No Yes 3 6 2 2
R:R:S203 R:R:Y199 11.45 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 12.86 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 4.13 1 Yes No 6 5 1 2
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 4.65 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 3.32 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 15.12 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 5.79 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.72
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG6 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 7.61 4 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 4.79 4 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 2.92 4 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 2.52 4 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 4.9 4 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 5.05 4 Yes Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:V117 2.92 4 Yes No 7 6 1 1
R:R:D113 R:R:Y316 11.49 4 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 16.42 4 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 6 No No 7 5 2 1
L:L:?1 R:R:V114 4.81 4 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 4 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 4 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 4 No No 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 9.83 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 6 No Yes 3 6 2 2
R:R:S203 R:R:Y199 2.54 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 4 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 4 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 4 Yes No 7 5 1 1
L:L:?1 R:R:S207 4.85 4 Yes No 0 5 0 1
R:R:F208 R:R:F290 21.43 4 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 4 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 4 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 10.72 4 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 2.42 4 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 6.19 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 9.67 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 4 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 4 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 3.49 4 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 4 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 7.62 4 Yes No 3 5 2 2
R:R:N312 R:R:Y316 15.12 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 9.65 4 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 4 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.59
Average Nodes In Shell26.00
Average Hubs In Shell14.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG7 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 8 Yes No 7 7 1 2
R:R:D113 R:R:V117 2.92 8 Yes No 7 6 1 1
R:R:D113 R:R:Y316 4.6 8 Yes No 7 6 1 2
L:L:?1 R:R:D113 14.23 8 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 3.61 8 Yes No 0 5 0 1
R:R:V117 R:R:W286 3.68 8 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 8 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 0 No No 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 9.83 8 Yes No 0 4 0 1
L:L:?1 R:R:S203 9.69 8 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 8 Yes No 7 5 1 2
L:L:?1 R:R:S207 4.85 8 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 0 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 4.01 8 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 8 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 8 Yes No 6 5 1 2
R:R:F289 R:R:N312 9.67 8 Yes No 6 5 1 1
L:L:?1 R:R:F289 6.88 8 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 4.91 8 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 12.79 8 No No 5 6 1 2
L:L:?1 R:R:N312 8.86 8 Yes No 0 5 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.92
Average Nodes In Shell20.00
Average Hubs In Shell7.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG8 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 1 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 5.99 1 Yes Yes 7 6 2 1
R:R:V86 R:R:W109 7.36 1 Yes Yes 7 5 2 2
R:R:D113 R:R:V86 4.38 1 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 2.45 1 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 5.05 1 Yes Yes 7 6 2 1
R:R:D113 R:R:W109 2.23 1 Yes Yes 7 5 1 2
R:R:D113 R:R:T110 4.34 1 Yes No 7 4 1 2
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
R:R:D113 R:R:V114 4.38 1 Yes No 7 5 1 2
L:L:?1 R:R:D113 13.14 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 1 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 1 Yes No 4 3 1 2
R:R:F193 R:R:Y308 2.06 1 Yes Yes 4 5 1 1
L:L:?1 R:R:F193 8.84 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 6.61 1 Yes No 7 5 1 2
R:R:F290 R:R:S207 3.96 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 15 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 2 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 4.13 1 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 2.44 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 1 Yes Yes 0 7 0 1
R:R:H296 R:R:Y308 6.53 0 No Yes 3 5 2 1
R:R:I309 R:R:Y308 2.42 0 No Yes 3 5 2 1
L:L:?1 R:R:Y308 2.84 1 Yes Yes 0 5 0 1
R:R:I309 R:R:W313 2.35 0 No Yes 3 5 2 2
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 8.86 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 11.58 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 1.89 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.13
Average Nodes In Shell26.00
Average Hubs In Shell14.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG9 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GG9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 3 No No 7 7 1 2
R:R:V86 R:R:Y316 6.31 3 No Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 9.2 3 No Yes 7 6 1 1
L:L:?1 R:R:D113 16.42 3 Yes No 0 7 0 1
R:R:V117 R:R:W286 3.68 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 3 Yes No 0 6 0 1
R:R:F193 R:R:T195 9.08 0 No No 4 3 1 2
L:L:?1 R:R:F193 8.84 3 Yes No 0 4 0 1
R:R:S203 R:R:Y199 2.54 0 No No 5 6 1 2
L:L:?1 R:R:S203 6.06 3 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 3 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 3 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 18.22 3 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 4.01 3 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 4.29 3 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 5.16 3 Yes No 6 5 1 2
R:R:F289 R:R:L311 2.44 3 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 10.87 3 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 3 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 3 Yes Yes 0 7 0 1
L:L:?1 R:R:N293 3.32 3 Yes No 0 5 0 1
R:R:N312 R:R:Y316 13.96 3 No Yes 5 6 1 1
L:L:?1 R:R:N312 9.97 3 Yes No 0 5 0 1
L:L:?1 R:R:Y316 2.84 3 Yes Yes 0 6 0 1
R:R:W313 R:R:Y316 1.93 0 Yes Yes 5 6 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.52
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGA A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V86 R:R:W109 2.45 3 No Yes 7 5 2 2
R:R:D113 R:R:V86 4.38 3 Yes No 7 7 1 2
R:R:D113 R:R:W109 3.35 3 Yes Yes 7 5 1 2
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:D113 R:R:V114 4.38 3 Yes No 7 5 1 1
R:R:D113 R:R:Y316 3.45 3 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 3 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 3 No No 7 5 2 1
L:L:?1 R:R:V114 7.21 3 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 3 No Yes 6 8 1 2
R:R:V117 R:R:Y316 2.52 3 No Yes 6 6 1 1
L:L:?1 R:R:V117 7.21 3 Yes No 0 6 0 1
R:R:S203 R:R:T164 3.2 0 No No 5 5 1 2
R:R:F193 R:R:T195 11.67 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 11.79 3 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 7.27 3 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 3 Yes No 7 5 1 2
R:R:N293 R:R:S204 2.98 3 Yes No 5 5 2 2
R:R:F208 R:R:W286 3.01 3 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 16.08 3 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 3 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 3 Yes Yes 7 8 1 2
R:R:F289 R:R:N293 10.87 3 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 15.71 3 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 3 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 3 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 19.77 3 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 3 Yes No 0 5 0 1
L:L:?1 R:R:Y316 5.67 3 Yes Yes 0 6 0 1
R:R:D192 R:R:F193 1.19 0 No Yes 3 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.33
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGB A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:Y316 3.45 2 Yes Yes 7 6 2 1
R:R:S165 R:R:V114 8.08 7 Yes No 7 5 2 1
R:R:V114 R:R:Y199 2.52 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 10.82 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 3.68 2 No Yes 6 8 1 2
R:R:V117 R:R:Y316 5.05 2 No Yes 6 6 1 1
L:L:?1 R:R:V117 8.41 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 2 Yes No 5 6 1 2
R:R:I121 R:R:W286 9.4 2 No Yes 7 8 2 2
R:R:F290 R:R:I121 2.51 2 Yes No 7 7 1 2
R:R:F193 R:R:T195 11.67 2 No No 4 3 1 2
R:R:F193 R:R:Y308 4.13 2 No Yes 4 5 1 1
L:L:?1 R:R:F193 8.84 2 Yes No 0 4 0 1
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 7.93 2 Yes Yes 7 5 1 2
R:R:N293 R:R:S204 4.47 2 Yes Yes 5 5 1 2
R:R:F290 R:R:S207 2.64 2 Yes Yes 7 5 1 1
L:L:?1 R:R:S207 3.63 2 Yes Yes 0 5 0 1
R:R:F208 R:R:W286 3.01 2 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 21.43 2 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 2 Yes Yes 7 8 1 2
R:R:W286 R:R:Y316 1.93 2 Yes Yes 8 6 2 1
R:R:F289 R:R:N293 4.83 2 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 2 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 9.67 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 2 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 2.55 0 No Yes 3 5 2 1
R:R:N293 R:R:Y308 3.49 2 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 4.43 2 Yes Yes 0 5 0 1
R:R:K305 R:R:Y308 8.36 0 Yes Yes 2 5 2 1
L:L:?1 R:R:Y308 7.57 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 19.77 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 8.86 2 Yes No 0 5 0 1
L:L:?1 R:R:Y316 5.67 2 Yes Yes 0 6 0 1
R:R:S207 R:R:V206 1.62 2 Yes No 5 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.25
Average Nodes In Shell24.00
Average Hubs In Shell14.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGC A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V86 R:R:W109 3.68 6 Yes Yes 7 5 2 2
R:R:D113 R:R:V86 5.84 6 Yes Yes 7 7 1 2
R:R:D113 R:R:W109 3.35 6 Yes Yes 7 5 1 2
R:R:D113 R:R:Y316 5.75 6 Yes No 7 6 1 1
L:L:?1 R:R:D113 12.04 6 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 8.08 0 No No 7 5 2 1
L:L:?1 R:R:V114 9.62 6 Yes No 0 5 0 1
R:R:V117 R:R:W286 2.45 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 6 Yes No 0 6 0 1
R:R:F193 R:R:Y308 7.22 6 No No 4 5 1 1
L:L:?1 R:R:F193 8.84 6 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 6 Yes No 0 5 0 1
R:R:F289 R:R:Y308 6.19 6 Yes No 6 5 2 1
R:R:F289 R:R:N312 9.67 6 Yes No 6 5 2 1
L:L:?1 R:R:Y308 4.73 6 Yes No 0 5 0 1
R:R:N312 R:R:Y316 23.26 6 No No 5 6 1 1
L:L:?1 R:R:N312 12.19 6 Yes No 0 5 0 1
L:L:?1 R:R:Y316 7.57 6 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.84
Average Nodes In Shell14.00
Average Hubs In Shell6.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGE A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 4 Yes Yes 7 7 2 2
R:R:D113 R:R:M82 2.77 4 Yes Yes 7 7 1 2
R:R:D113 R:R:V86 2.92 4 Yes Yes 7 7 1 2
R:R:D113 R:R:V117 2.92 4 Yes No 7 6 1 1
R:R:D113 R:R:Y316 2.3 4 Yes No 7 6 1 1
L:L:?1 R:R:D113 10.95 4 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 11 Yes No 7 5 2 1
L:L:?1 R:R:V114 14.42 4 Yes No 0 5 0 1
R:R:V117 R:R:W286 6.13 4 No Yes 6 8 1 2
L:L:?1 R:R:V117 4.81 4 Yes No 0 6 0 1
R:R:F193 R:R:Y308 2.06 4 No Yes 4 5 1 1
L:L:?1 R:R:F193 9.83 4 Yes No 0 4 0 1
L:L:?1 R:R:S203 4.85 4 Yes No 0 5 0 1
R:R:V292 R:R:Y308 2.52 0 No Yes 5 5 2 1
R:R:N312 R:R:Y308 12.79 4 No Yes 5 5 1 1
L:L:?1 R:R:Y308 2.84 4 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 8.14 4 No No 5 6 1 1
L:L:?1 R:R:N312 4.43 4 Yes No 0 5 0 1
L:L:?1 R:R:Y316 6.62 4 Yes No 0 6 0 1
R:R:I309 R:R:Y308 1.21 0 No Yes 3 5 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.34
Average Nodes In Shell15.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGF A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C116 R:R:D113 4.67 0 No Yes 7 7 2 1
R:R:D113 R:R:V117 2.92 7 Yes Yes 7 6 1 1
R:R:D113 R:R:N312 2.69 7 Yes No 7 5 1 1
R:R:D113 R:R:Y316 11.49 7 Yes No 7 6 1 2
L:L:?1 R:R:D113 15.33 7 Yes Yes 0 7 0 1
L:L:?1 R:R:V114 20.43 7 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 7 Yes Yes 7 6 2 1
R:R:F208 R:R:V117 3.93 7 Yes Yes 8 6 2 1
L:L:?1 R:R:V117 8.41 7 Yes Yes 0 6 0 1
R:R:F208 R:R:I121 10.05 7 Yes Yes 8 7 2 2
R:R:F193 R:R:Y308 6.19 0 No Yes 4 5 2 1
R:R:A200 R:R:S203 3.42 0 No No 5 5 2 1
L:L:?1 R:R:S203 2.42 7 Yes No 0 5 0 1
R:R:N293 R:R:S204 2.98 7 No No 5 5 1 1
L:L:?1 R:R:S204 7.27 7 Yes No 0 5 0 1
R:R:F208 R:R:F289 3.22 7 Yes Yes 8 6 2 1
R:R:F289 R:R:N293 19.33 7 Yes No 6 5 1 1
R:R:F289 R:R:Y308 6.19 7 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 8.46 7 Yes No 6 5 1 1
L:L:?1 R:R:F289 11.79 7 Yes Yes 0 6 0 1
R:R:V292 R:R:Y308 2.52 0 No Yes 5 5 2 1
L:L:?1 R:R:N293 5.54 7 Yes No 0 5 0 1
L:L:?1 R:R:Y308 4.73 7 Yes Yes 0 5 0 1
L:L:?1 R:R:N312 12.19 7 Yes No 0 5 0 1
R:R:I309 R:R:Y308 1.21 0 No Yes 3 5 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.79
Average Nodes In Shell18.00
Average Hubs In Shell7.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGI A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 1 Yes No 7 7 1 2
R:R:V86 R:R:Y316 6.31 1 No Yes 7 6 2 1
R:R:D113 R:R:W109 12.28 1 Yes No 7 5 1 2
R:R:D113 R:R:Y316 4.6 1 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 5.47 1 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 3.61 1 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 0 No No 7 6 2 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:Y174 7.22 0 Yes Yes 4 5 1 2
R:R:Y174 R:R:Y199 3.97 7 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 7.78 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 6.88 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 4.99 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 10.17 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes No 5 5 2 2
L:L:?1 R:R:S207 3.63 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 4.29 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 7.25 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 1 Yes Yes 0 6 0 1
R:R:F290 R:R:N293 3.62 1 Yes Yes 7 5 1 2
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 3.49 1 Yes No 5 5 2 2
R:R:N312 R:R:Y316 9.3 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.49
Average Nodes In Shell26.00
Average Hubs In Shell13.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGJ A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 8.76 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 6.01 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No Yes 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 9.83 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 7.45 1 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 3.63 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 18.22 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 10.72 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 0 Yes Yes 3 5 2 1
L:L:?1 R:R:N293 3.32 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 7.62 0 Yes No 3 5 2 2
R:R:N312 R:R:Y316 6.98 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 3.86 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.59
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGK A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 7.61 0 No Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 No No 7 6 2 1
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 2
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 13.14 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 6.01 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 6.13 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:Y174 3.09 1 No Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 Yes Yes 3 5 2 2
R:R:Y174 R:R:Y199 4.96 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 9.08 1 No Yes 4 3 1 2
L:L:?1 R:R:F193 11.79 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 1 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 6.06 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 3.62 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 9.28 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 4.65 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 9.3 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.83
Average Nodes In Shell23.00
Average Hubs In Shell12.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGL A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 2
R:R:D113 R:R:Y316 8.05 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 7.21 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 6.13 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No No 5 6 1 2
R:R:F193 R:R:Y174 5.16 1 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 Yes Yes 3 5 2 2
R:R:Y174 R:R:Y199 4.96 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 6.49 1 Yes Yes 4 3 1 2
L:L:?1 R:R:F193 11.79 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 1 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 6.06 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 13.29 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 3.27 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 6.98 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.54
Average Nodes In Shell24.00
Average Hubs In Shell14.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGM A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 2.92 0 No Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
R:R:D113 R:R:Y316 10.34 0 No No 7 6 1 2
L:L:?1 R:R:D113 9.85 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
R:R:V114 R:R:Y199 2.52 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 7.21 1 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 1 No Yes 7 6 2 1
R:R:V117 R:R:W286 4.9 1 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No Yes 5 6 1 2
R:R:I121 R:R:W286 8.22 1 No Yes 7 8 2 2
R:R:F193 R:R:Y174 3.09 1 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 Yes Yes 3 5 2 2
R:R:Y174 R:R:Y199 4.96 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 6.49 1 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 3.09 1 Yes Yes 4 5 1 2
L:L:?1 R:R:F193 10.81 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 1 Yes Yes 3 6 2 2
R:R:H296 R:R:T195 2.74 1 Yes Yes 3 3 2 2
R:R:S203 R:R:Y199 3.82 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 6.06 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 16.08 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 6.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 6.43 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 10.32 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 4.91 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 3.27 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 10.47 1 No No 5 6 1 2
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.90
Average Nodes In Shell26.00
Average Hubs In Shell16.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGN A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 4.56 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:D113 R:R:Y316 13.79 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
L:L:?1 R:R:V114 7.21 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No No 4 3 1 2
L:L:?1 R:R:F193 8.84 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 3.82 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 10.9 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 2.98 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 13.93 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 9.65 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 5.9 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 4.91 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 5.81 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 6.53 1 Yes No 3 5 2 2
R:R:N312 R:R:Y316 10.47 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.58
Average Nodes In Shell25.00
Average Hubs In Shell13.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGO A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V117 3.04 0 No No 7 6 2 1
R:R:D113 R:R:V86 5.84 1 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 8.76 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 7 Yes No 7 5 2 1
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No No 5 6 1 2
R:R:F193 R:R:T195 3.89 0 No No 4 3 1 2
L:L:?1 R:R:F193 9.83 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 16.08 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 3.22 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 6.04 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 3.93 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 No Yes 3 5 2 1
R:R:N293 R:R:Y308 5.81 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 10.89 1 No No 3 5 2 2
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.64
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGP A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 0 No No 7 7 1 2
R:R:D113 R:R:Y316 9.2 0 No No 7 6 1 2
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 8.08 0 No No 7 5 2 1
L:L:?1 R:R:V114 6.01 1 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 1 No No 7 6 2 1
R:R:V117 R:R:W286 4.9 1 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No No 5 6 1 2
R:R:I121 R:R:W286 8.22 1 No Yes 7 8 2 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 11.79 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
R:R:F290 R:R:S207 5.28 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 3.63 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 17.15 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 4.29 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 13.29 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 6.88 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 4.91 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 3.83 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 8.71 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 10.47 1 No No 5 6 1 2
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.53
Average Nodes In Shell22.00
Average Hubs In Shell8.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGQ A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 5 Yes No 7 5 2 1
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:Y174 5.16 1 No Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 Yes Yes 3 5 2 2
R:R:F193 R:R:T195 6.49 1 No Yes 4 3 1 2
L:L:?1 R:R:F193 9.83 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 2.98 1 Yes No 5 5 1 2
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 16.08 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 6.88 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 8.14 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 7.62 1 Yes No 3 5 2 2
R:R:N312 R:R:Y316 10.47 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 7.72 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.21
Average Nodes In Shell22.00
Average Hubs In Shell13.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGR A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 5.84 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 2
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 12.04 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 4 Yes No 7 5 2 1
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 8.84 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes No 6 7 1 2
R:R:F289 R:R:Y308 8.25 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 1 Yes Yes 0 6 0 1
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.44
Average Nodes In Shell18.00
Average Hubs In Shell9.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGS A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 2
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 12.04 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 Yes No 7 5 2 1
L:L:?1 R:R:V114 6.01 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:Y174 5.16 1 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 Yes Yes 3 5 2 2
R:R:F193 R:R:T195 10.38 1 Yes Yes 4 3 1 2
L:L:?1 R:R:F193 13.76 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 4.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 6.04 1 Yes No 6 5 1 2
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 4.65 1 No No 5 5 2 2
R:R:N312 R:R:Y316 8.14 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.64
Average Nodes In Shell20.00
Average Hubs In Shell12.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGT A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 4.38 1 No Yes 7 7 1 2
R:R:D113 R:R:Y316 12.64 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 9.85 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
R:R:I169 R:R:V114 3.07 0 No No 5 5 2 1
L:L:?1 R:R:V114 3.61 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:Y174 7.22 0 Yes Yes 4 5 1 2
R:R:F193 R:R:T195 6.49 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 7.86 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 0 No No 5 5 2 2
R:R:F290 R:R:S207 3.96 1 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:W286 R:R:Y316 2.89 1 Yes Yes 8 6 2 1
R:R:F289 R:R:F290 4.29 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 7.25 1 Yes No 6 5 1 2
R:R:F289 R:R:Y308 7.22 1 Yes No 6 5 1 1
R:R:F289 R:R:N312 13.29 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 5.9 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y308 3.78 1 Yes No 0 5 0 1
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
L:L:?1 R:R:Y316 4.73 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:I309 R:R:Y308 2.42 0 No No 3 5 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.74
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGU A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 8.76 1 Yes No 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:F193 R:R:T110 3.89 0 No No 4 4 1 2
R:R:D113 R:R:V117 2.92 1 Yes No 7 6 1 1
R:R:D113 R:R:Y316 11.49 1 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 1 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 0 Yes No 7 5 2 1
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 1 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No No 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 6.88 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 2.54 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 2.42 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 22.51 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 10.87 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 4.91 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 3.32 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 4.36 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 9.3 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.90
Average Nodes In Shell24.00
Average Hubs In Shell13.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGV A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 1 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:F193 R:R:T110 3.89 1 Yes No 4 4 1 2
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 14.23 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 4 Yes No 7 5 2 1
L:L:?1 R:R:V114 7.21 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:Y174 5.16 1 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 3.75 1 No Yes 3 5 2 2
R:R:F193 R:R:T195 5.19 1 Yes No 4 3 1 2
L:L:?1 R:R:F193 6.88 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 22.51 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 6.43 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 13.29 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 9.3 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 3.86 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.96
Average Nodes In Shell20.00
Average Hubs In Shell11.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGW A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 2 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 2 No Yes 7 6 2 1
R:R:F193 R:R:T110 3.89 0 No No 4 4 1 2
R:R:D113 R:R:Y316 10.34 2 No Yes 7 6 1 1
L:L:?1 R:R:D113 14.23 2 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 0 Yes No 7 5 2 1
R:R:V114 R:R:Y199 2.52 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 6.01 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 2 Yes No 0 6 0 1
R:R:S207 R:R:T118 4.8 0 No No 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 6.88 2 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 1 No Yes 3 6 2 2
R:R:S203 R:R:Y199 2.54 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 2 Yes No 0 5 0 1
R:R:F290 R:R:S207 2.64 2 Yes No 7 5 2 1
L:L:?1 R:R:S207 3.63 2 Yes No 0 5 0 1
R:R:F289 R:R:W286 7.02 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 2 Yes Yes 7 8 2 2
R:R:F289 R:R:F290 9.65 2 Yes Yes 6 7 1 2
R:R:F289 R:R:Y308 6.19 2 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 2 Yes Yes 0 6 0 1
R:R:N312 R:R:Y316 12.79 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 2 Yes No 0 5 0 1
R:R:W313 R:R:Y316 4.82 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 5.67 2 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.24
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGX A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes No 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 10.22 1 No No 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 No Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 9.85 1 Yes No 0 7 0 1
L:L:?1 R:R:V114 10.82 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 6.61 1 Yes No 7 5 1 2
R:R:F208 R:R:W286 4.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 25.72 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 4.73 1 Yes Yes 0 6 0 1
R:R:F289 R:R:N293 2.42 1 Yes Yes 6 5 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.20
Average Nodes In Shell19.00
Average Hubs In Shell8.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGY A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.9 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 8.76 1 Yes No 7 7 2 2
R:R:V86 R:R:Y316 5.05 1 No Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 4.6 1 Yes Yes 7 6 2 1
R:R:S165 R:R:V114 6.46 6 Yes No 7 5 2 1
L:L:?1 R:R:V114 3.61 1 Yes No 0 5 0 1
R:R:I121 R:R:V117 3.07 0 No No 7 6 2 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:I121 R:R:S207 6.19 0 No No 7 5 2 2
R:R:F193 R:R:T195 7.78 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 13.76 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 24.65 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 3.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:Y308 7.22 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 14.5 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 10.47 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
L:L:?1 R:R:Y316 4.73 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.35
Average Nodes In Shell20.00
Average Hubs In Shell9.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGZ A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 3.9 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GGZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 16.07 1 Yes Yes 7 7 2 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 5.75 1 Yes Yes 7 6 2 1
L:L:?1 R:R:V114 13.22 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 7.78 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 6.88 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:W286 3.01 1 Yes Yes 7 8 2 2
R:R:F289 R:R:F290 4.29 1 Yes Yes 6 7 1 2
R:R:F289 R:R:Y308 7.22 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 1 Yes Yes 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
R:R:N312 R:R:Y316 10.47 1 Yes Yes 5 6 1 1
L:L:?1 R:R:N312 7.75 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y316 4.73 1 Yes Yes 0 6 0 1
R:R:I309 R:R:N312 1.42 0 No Yes 3 5 2 1
R:R:D192 R:R:F193 1.19 0 No Yes 3 4 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.13
Average Nodes In Shell17.00
Average Hubs In Shell9.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GH0 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GH0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V86 R:R:W109 6.13 1 Yes Yes 7 5 2 2
R:R:I112 R:R:V86 3.07 1 No Yes 4 7 2 2
R:R:D113 R:R:V86 13.15 1 Yes Yes 7 7 1 2
R:R:D113 R:R:W109 12.28 1 Yes Yes 7 5 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:I112 2.8 1 Yes No 7 4 1 2
R:R:D113 R:R:Y316 5.75 1 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 4.38 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V114 16.83 1 Yes No 0 5 0 1
R:R:C116 R:R:V117 3.42 0 No No 7 6 2 1
R:R:V117 R:R:W286 6.13 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 3.61 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 6.49 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 13.76 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 4.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 24.65 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 11.79 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 7.25 1 Yes No 6 5 1 2
R:R:F289 R:R:Y308 6.19 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 3.93 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 2.95 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 15.12 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 1 No Yes 5 6 2 1
L:L:?1 R:R:Y316 6.62 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.68
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GH1 A Amine Adrenergic Beta2 Homo sapiens Epinephrine - - 4.1 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8GH1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 0 No No 7 7 1 2
R:R:D113 R:R:Y316 8.05 0 No Yes 7 6 1 2
L:L:?1 R:R:D113 9.85 1 Yes No 0 7 0 1
L:L:?1 R:R:V114 9.62 1 Yes No 0 5 0 1
R:R:C116 R:R:V117 1.71 0 No No 7 6 2 1
L:L:?1 R:R:V117 6.01 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 3.89 1 No No 4 3 1 2
R:R:F193 R:R:Y308 4.13 1 No Yes 4 5 1 1
L:L:?1 R:R:F193 14.74 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No No 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No No 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F289 R:R:N293 2.42 1 Yes Yes 6 5 2 1
R:R:F289 R:R:Y308 7.22 1 Yes Yes 6 5 2 1
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 2 1
R:R:H296 R:R:N293 6.38 0 No Yes 3 5 2 1
R:R:N293 R:R:Y308 4.65 1 Yes Yes 5 5 1 1
L:L:?1 R:R:N293 5.54 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y308 1.89 1 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 5.81 0 No Yes 5 6 1 2
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.39
Average Nodes In Shell16.00
Average Hubs In Shell5.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNL A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 0 No No 7 7 1 2
R:R:D113 R:R:Y316 11.49 0 No Yes 7 6 1 2
L:L:?1 R:R:D113 10.95 9 Yes No 0 7 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 9 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 9 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 9 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 9 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 0 No No 5 5 1 2
L:L:?1 R:R:S207 4.85 9 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 9 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 9 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 9 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 9 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 6.19 9 Yes No 6 5 1 2
R:R:F289 R:R:N312 7.25 9 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 9 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 9 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 4.65 0 No No 5 5 1 2
L:L:?1 R:R:N293 3.32 9 Yes No 0 5 0 1
R:R:N312 R:R:Y316 10.47 9 No Yes 5 6 1 2
L:L:?1 R:R:N312 12.19 9 Yes No 0 5 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.39
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNM A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 11.69 5 No Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 5 Yes No 4 4 1 2
R:R:D113 R:R:Y316 11.49 5 No No 7 6 1 1
L:L:?1 R:R:D113 10.95 5 Yes No 0 7 0 1
R:R:V117 R:R:W286 6.13 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 5 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 5 No No 5 6 1 2
R:R:F193 R:R:T195 10.38 5 Yes No 4 3 1 2
R:R:F193 R:R:Y308 2.06 5 Yes Yes 4 5 1 1
L:L:?1 R:R:F193 12.77 5 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 3.75 5 No Yes 3 6 2 2
R:R:S203 R:R:Y199 3.82 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 5 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 5 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 0 No No 5 5 1 2
R:R:F290 R:R:S207 2.64 5 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 5 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 5 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 5 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 5.16 5 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 9.67 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 7.86 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 4.91 5 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 3.83 0 No No 3 5 2 1
L:L:?1 R:R:N293 2.22 5 Yes No 0 5 0 1
R:R:H296 R:R:Y308 10.89 0 No Yes 3 5 2 1
L:L:?1 R:R:Y308 1.89 5 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 9.3 5 No No 5 6 1 1
L:L:?1 R:R:N312 12.19 5 Yes No 0 5 0 1
L:L:?1 R:R:Y316 4.73 5 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.77
Average Nodes In Shell21.00
Average Hubs In Shell9.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNN A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 4.56 0 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 2.39 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 10.22 6 No Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 11.49 6 No Yes 7 6 1 1
L:L:?1 R:R:D113 8.76 6 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 5 Yes No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 8.41 6 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 6 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 6 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 0 Yes No 4 3 1 2
R:R:F193 R:R:Y308 2.06 0 Yes Yes 4 5 1 2
L:L:?1 R:R:F193 9.83 6 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 3.75 5 No Yes 3 6 2 2
R:R:S203 R:R:Y199 2.54 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 6 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 6 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 6 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 6 Yes No 7 5 1 1
L:L:?1 R:R:S207 4.85 6 Yes No 0 5 0 1
R:R:F208 R:R:F290 16.08 0 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 4.01 6 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 6 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 4.83 6 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 6 Yes Yes 6 5 1 2
R:R:F289 R:R:L311 2.44 6 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 7.25 6 Yes No 6 5 1 1
L:L:?1 R:R:F289 3.93 6 Yes Yes 0 6 0 1
R:R:F290 R:R:N293 2.42 6 Yes Yes 7 5 1 1
L:L:?1 R:R:F290 5.9 6 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 6 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 3.49 6 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 4.43 6 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 8.71 6 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 11.63 6 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 6 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 6 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.19
Average Nodes In Shell26.00
Average Hubs In Shell15.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNO A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V117 2.92 4 No No 7 6 1 1
R:R:D113 R:R:Y316 9.2 4 No No 7 6 1 2
L:L:?1 R:R:D113 15.33 4 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No No 5 6 1 2
L:L:?1 R:R:V114 6.01 4 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 4 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 4 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 10.81 4 Yes No 0 4 0 1
R:R:S203 R:R:Y199 8.9 0 No No 5 6 1 2
L:L:?1 R:R:S203 8.48 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 7.93 0 Yes No 7 5 1 2
L:L:?1 R:R:S207 3.63 4 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 13 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 4 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 0 Yes Yes 7 8 1 2
R:R:F289 R:R:Y308 9.28 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 4 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 8.14 4 No No 5 6 1 2
L:L:?1 R:R:N312 13.29 4 Yes No 0 5 0 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.16
Average Nodes In Shell20.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNP A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
R:R:I169 R:R:T110 4.56 1 Yes No 5 4 2 2
R:R:F193 R:R:T110 2.59 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 1 No Yes 7 5 2 1
R:R:I169 R:R:V114 3.07 1 Yes Yes 5 5 2 1
R:R:V114 R:R:Y199 2.52 1 Yes Yes 5 6 1 2
L:L:?1 R:R:V114 2.4 1 Yes Yes 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No No 5 6 1 2
R:R:I169 R:R:Y199 4.84 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 6.49 0 Yes No 4 3 1 2
R:R:F193 R:R:Y308 2.06 0 Yes Yes 4 5 1 2
L:L:?1 R:R:F193 12.77 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 3.63 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 2 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 8.46 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 1 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 3.32 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 15.24 1 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 8.68 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.41
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNQ A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 1 Yes No 7 7 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:V117 2.92 1 Yes No 7 6 1 1
R:R:D113 R:R:Y316 12.64 1 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 1 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 5 No No 7 5 2 1
R:R:V114 R:R:Y199 2.52 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 2.4 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 1 No Yes 6 8 1 2
L:L:?1 R:R:V117 9.62 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 1 No No 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 10.81 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 5 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 8.9 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 1 Yes No 7 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 8.46 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 12.77 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 9.3 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 13.29 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 4.82 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.29
Average Nodes In Shell22.00
Average Hubs In Shell10.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNR A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 7.3 7 Yes No 7 7 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:V117 4.38 7 Yes No 7 6 1 1
R:R:D113 R:R:Y316 11.49 7 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 14.23 7 Yes Yes 0 7 0 1
R:R:V117 R:R:W286 4.9 7 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 7 Yes No 0 6 0 1
R:R:S207 R:R:T118 3.2 7 No No 5 6 1 2
R:R:F193 R:R:T195 10.38 0 No No 4 3 1 2
L:L:?1 R:R:F193 10.81 7 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 9 No Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 7 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 7 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 7 Yes No 5 5 1 2
R:R:F290 R:R:S207 5.28 7 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 7 Yes No 0 5 0 1
R:R:F208 R:R:W286 2 7 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 21.43 7 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 7 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 5.01 7 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 2.14 7 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 11.35 7 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 8.46 7 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 7 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 7 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 3.83 7 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 7 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 2.22 7 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 10.89 7 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 11.63 7 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 7 Yes No 0 5 0 1
R:R:W313 R:R:Y316 3.86 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 7 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.78
Average Nodes In Shell22.00
Average Hubs In Shell11.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNS A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 4.56 4 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 2.39 4 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 4 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 2.52 4 Yes Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:V117 2.92 4 Yes No 7 6 1 1
R:R:D113 R:R:Y316 11.49 4 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 9.85 4 Yes Yes 0 7 0 1
R:R:V117 R:R:W286 6.13 4 No Yes 6 8 1 2
L:L:?1 R:R:V117 9.62 4 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 4 No No 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 10.81 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 6.24 8 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 3.82 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 4 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 4 Yes No 5 5 1 2
R:R:F290 R:R:S207 2.64 4 Yes No 7 5 1 1
L:L:?1 R:R:S207 4.85 4 Yes No 0 5 0 1
R:R:F208 R:R:W286 2 4 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 21.43 4 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 4.01 4 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 4.29 4 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 4 Yes No 6 5 1 2
R:R:F289 R:R:N312 7.25 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 4 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 2.55 4 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 6.98 4 Yes No 5 5 1 2
L:L:?1 R:R:N293 3.32 4 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 6.53 4 Yes No 3 5 2 2
R:R:N312 R:R:Y316 15.12 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 8.86 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 5.79 4 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 1.89 4 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.46
Average Nodes In Shell23.00
Average Hubs In Shell14.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNT A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 0 No No 7 7 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 12.64 0 No No 7 6 1 2
L:L:?1 R:R:D113 9.85 9 Yes No 0 7 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 9 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 9 No No 5 6 1 2
R:R:F193 R:R:T195 5.19 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 9 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 8 No Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 9 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 9 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 0 No No 5 5 1 2
R:R:F290 R:R:S207 2.64 9 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 9 Yes No 0 5 0 1
R:R:F208 R:R:F290 18.22 9 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 9 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 9 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 9 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 9.28 9 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 9 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 9 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 9 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 0 Yes No 3 5 2 1
L:L:?1 R:R:N293 3.32 9 Yes No 0 5 0 1
R:R:H296 R:R:Y308 8.71 0 Yes No 3 5 2 2
R:R:N312 R:R:Y316 11.63 9 No No 5 6 1 2
L:L:?1 R:R:N312 12.19 9 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.97
Average Nodes In Shell21.00
Average Hubs In Shell7.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNU A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 10.22 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 10.95 1 Yes No 0 7 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 7.99 1 No Yes 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 10.81 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 0 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes Yes 7 5 1 2
R:R:N293 R:R:S204 5.96 1 Yes Yes 5 5 1 2
R:R:F290 R:R:S207 2.64 1 Yes No 7 5 1 1
L:L:?1 R:R:S207 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 20.36 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 6.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:Y308 11.35 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 1 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 3.49 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 3.32 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 7.62 1 Yes No 3 5 2 2
R:R:N312 R:R:Y316 12.79 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 8.86 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.07
Average Nodes In Shell21.00
Average Hubs In Shell13.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNV A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:M82 R:R:Y316 3.59 0 Yes Yes 7 6 2 2
R:R:D113 R:R:V86 8.76 6 Yes No 7 7 1 2
R:R:D113 R:R:V117 2.92 6 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 11.49 6 Yes Yes 7 6 1 2
L:L:?1 R:R:D113 10.95 6 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 3.23 16 Yes No 7 5 2 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 6.01 6 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 6 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 6 Yes Yes 0 6 0 1
R:R:F193 R:R:T195 11.67 0 No No 4 3 1 2
L:L:?1 R:R:F193 13.76 6 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 8.48 6 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 6 Yes No 7 5 1 2
R:R:F208 R:R:F290 20.36 6 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 6 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 6 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 6 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 7.22 6 Yes No 6 5 1 2
R:R:F289 R:R:N312 9.67 6 Yes No 6 5 1 1
L:L:?1 R:R:F289 6.88 6 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 6 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 11.63 6 No Yes 5 6 1 2
L:L:?1 R:R:N312 8.86 6 Yes No 0 5 0 1
R:R:F289 R:R:L311 2.44 6 Yes No 6 5 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.66
Average Nodes In Shell20.00
Average Hubs In Shell11.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNW A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes No 7 7 2 2
R:R:M82 R:R:Y316 5.99 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 10.22 4 No No 7 7 1 2
R:R:D113 R:R:Y316 10.34 4 No Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 4 Yes No 0 7 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 6.01 4 Yes No 0 6 0 1
R:R:F193 R:R:T195 9.08 0 No No 4 3 1 2
R:R:F193 R:R:Y308 5.16 0 No Yes 4 5 1 2
L:L:?1 R:R:F193 10.81 4 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 9.69 4 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 0 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 4 Yes No 5 5 1 2
R:R:F208 R:R:F290 19.29 29 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 3.01 4 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 3.01 0 Yes Yes 7 8 1 2
R:R:F289 R:R:Y308 8.25 4 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 10.87 4 Yes No 6 5 1 1
L:L:?1 R:R:F289 6.88 4 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.86 4 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 4 Yes Yes 3 5 2 1
R:R:N293 R:R:Y308 4.65 4 Yes Yes 5 5 1 2
L:L:?1 R:R:N293 3.32 4 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 9.8 4 Yes Yes 3 5 2 2
R:R:N312 R:R:Y316 15.12 4 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 4 Yes No 0 5 0 1
R:R:W313 R:R:Y316 9.65 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 4 Yes Yes 0 6 0 1
R:R:F289 R:R:L311 2.44 4 Yes No 6 5 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.94
Average Nodes In Shell21.00
Average Hubs In Shell12.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNX A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V86 R:R:Y316 2.52 0 Yes Yes 7 6 2 1
R:R:F193 R:R:T110 5.19 0 Yes No 4 4 1 2
R:R:D113 R:R:Y316 11.49 7 No Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 7 Yes No 0 7 0 1
R:R:I121 R:R:V117 3.07 7 Yes No 7 6 2 1
R:R:V117 R:R:W286 4.9 7 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 7 Yes No 0 6 0 1
R:R:I121 R:R:S207 3.1 7 Yes No 7 5 2 2
R:R:I121 R:R:W286 8.22 7 Yes Yes 7 8 2 2
R:R:F290 R:R:I121 2.51 7 Yes Yes 7 7 1 2
R:R:F193 R:R:Y174 5.16 0 Yes Yes 4 5 1 2
R:R:F193 R:R:T195 7.78 0 Yes No 4 3 1 2
L:L:?1 R:R:F193 9.83 7 Yes Yes 0 4 0 1
R:R:S203 R:R:Y199 2.54 0 No No 5 6 1 2
L:L:?1 R:R:S203 7.27 7 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 7 Yes No 7 5 1 2
R:R:F290 R:R:S207 5.28 7 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 7 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 17.15 7 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 3.01 7 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 3.22 7 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 7 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 7 Yes No 6 5 1 1
L:L:?1 R:R:F289 8.84 7 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 7 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 10.47 7 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 7 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 7 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.13
Average Nodes In Shell21.00
Average Hubs In Shell11.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNY A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:Y316 2.39 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 10.22 5 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 5 Yes Yes 7 6 2 1
R:R:I169 R:R:T110 3.04 5 Yes No 5 4 2 2
R:R:F193 R:R:T110 2.59 5 Yes No 4 4 1 2
R:R:D113 R:R:V117 2.92 5 Yes No 7 6 1 1
R:R:D113 R:R:Y316 12.64 5 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 13.14 5 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 1.62 11 Yes No 7 5 2 1
R:R:I169 R:R:V114 3.07 5 Yes No 5 5 2 1
L:L:?1 R:R:V114 7.21 5 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 5 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 5 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 5 No No 5 6 1 2
R:R:S203 R:R:T164 1.6 0 No No 5 5 1 2
R:R:F193 R:R:T195 7.78 5 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 2.06 5 Yes Yes 4 5 1 1
L:L:?1 R:R:F193 13.76 5 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 8.48 5 Yes No 0 5 0 1
R:R:F290 R:R:S207 2.64 5 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 5 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 5 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 19.29 5 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 5.01 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 2.14 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 11.35 5 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 14.5 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 5 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 6.38 5 Yes No 3 5 2 1
R:R:N293 R:R:Y308 9.3 5 No Yes 5 5 1 1
L:L:?1 R:R:N293 6.65 5 Yes No 0 5 0 1
R:R:H296 R:R:Y308 11.98 5 Yes Yes 3 5 2 1
L:L:?1 R:R:Y308 1.89 5 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 15.12 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 4.43 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 5 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.58
Average Nodes In Shell25.00
Average Hubs In Shell16.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNZ A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.8 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UNZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 8.76 5 No No 7 7 1 2
R:R:D113 R:R:Y316 11.49 5 No Yes 7 6 1 1
L:L:?1 R:R:D113 12.04 5 Yes No 0 7 0 1
L:L:?1 R:R:V114 3.61 5 Yes No 0 5 0 1
L:L:?1 R:R:V117 7.21 5 Yes No 0 6 0 1
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 7.86 5 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 10 No Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 5 Yes No 0 5 0 1
R:R:F290 R:R:S204 6.61 5 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 5 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 21.43 5 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 5 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 5 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 6.43 5 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 3.09 5 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 5 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 5 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 2.55 0 Yes No 3 5 2 1
L:L:?1 R:R:N293 6.65 5 Yes No 0 5 0 1
R:R:H296 R:R:Y308 7.62 0 Yes No 3 5 2 2
R:R:N312 R:R:Y316 13.96 5 No Yes 5 6 1 1
L:L:?1 R:R:N312 9.97 5 Yes No 0 5 0 1
R:R:W313 R:R:Y316 6.75 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 5 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.22
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO0 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UO0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:Y316 5.99 0 No Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 14 No Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 13.79 14 No Yes 7 6 1 1
L:L:?1 R:R:D113 8.76 14 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 7.21 14 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 4.81 14 Yes No 0 6 0 1
R:R:F193 R:R:T195 9.08 0 No No 4 3 1 2
L:L:?1 R:R:F193 10.81 14 Yes No 0 4 0 1
R:R:T195 R:R:Y199 4.99 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 2.54 0 No Yes 5 6 1 2
R:R:A200 R:R:N293 3.13 0 No Yes 5 5 2 1
L:L:?1 R:R:S203 9.69 14 Yes No 0 5 0 1
R:R:F290 R:R:S204 7.93 0 Yes No 7 5 2 2
R:R:N293 R:R:S204 4.47 0 Yes No 5 5 1 2
R:R:F289 R:R:F290 5.36 14 Yes Yes 6 7 1 2
R:R:F289 R:R:Y308 7.22 14 Yes No 6 5 1 2
R:R:F289 R:R:L311 2.44 14 Yes No 6 5 1 2
R:R:F289 R:R:N312 7.25 14 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.83 14 Yes Yes 0 6 0 1
R:R:H296 R:R:N293 7.65 0 No Yes 3 5 2 1
L:L:?1 R:R:N293 4.43 14 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 13.07 0 No No 3 5 2 2
R:R:N312 R:R:Y316 15.12 14 No Yes 5 6 1 1
L:L:?1 R:R:N312 9.97 14 Yes No 0 5 0 1
R:R:W313 R:R:Y316 8.68 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 14 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.59
Average Nodes In Shell24.00
Average Hubs In Shell9.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO1 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP; Mg Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UO1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:M82 R:R:Y316 2.39 0 Yes Yes 7 6 2 2
R:R:D113 R:R:V86 8.76 2 Yes Yes 7 7 1 2
R:R:D113 R:R:V117 4.38 2 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 10.34 2 Yes Yes 7 6 1 2
L:L:?1 R:R:D113 10.95 2 Yes Yes 0 7 0 1
R:R:V117 R:R:W286 3.68 2 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 2 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 7.99 2 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 2 Yes No 4 3 1 2
R:R:F193 R:R:K305 2.48 2 Yes No 4 2 1 2
R:R:F193 R:R:Y308 7.22 2 Yes Yes 4 5 1 1
L:L:?1 R:R:F193 14.74 2 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 5.09 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.27 2 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 2 Yes No 7 5 1 2
R:R:F290 R:R:S207 2.64 2 Yes No 7 5 1 1
L:L:?1 R:R:S207 2.42 2 Yes No 0 5 0 1
R:R:F208 R:R:F290 15 0 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 3.01 2 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 8.57 2 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 9.28 2 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 2.44 2 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 7.25 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 6.88 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 3.93 2 Yes Yes 0 7 0 1
R:R:H296 R:R:I303 6.63 2 Yes No 3 3 2 2
R:R:H296 R:R:Y308 13.07 2 Yes Yes 3 5 2 1
R:R:I303 R:R:Y308 3.63 2 No Yes 3 5 2 1
L:L:?1 R:R:Y308 2.84 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 11.63 2 No Yes 5 6 1 2
L:L:?1 R:R:N312 11.08 2 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.48
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO2 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UO2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 11.69 2 Yes Yes 7 7 1 2
R:R:F193 R:R:T110 2.59 2 Yes No 4 4 1 2
R:R:D113 R:R:V117 4.38 2 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 12.64 2 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 10.95 2 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 4.85 0 No No 7 5 2 1
L:L:?1 R:R:V114 6.01 2 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 2 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 2 Yes Yes 0 6 0 1
R:R:F193 R:R:Y174 13.41 2 Yes Yes 4 5 1 2
R:R:T195 R:R:Y174 12.48 2 Yes Yes 3 5 2 2
R:R:F193 R:R:T195 2.59 2 Yes Yes 4 3 1 2
R:R:F193 R:R:Y308 5.16 2 Yes Yes 4 5 1 1
L:L:?1 R:R:F193 27.51 2 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 8.48 2 Yes No 0 5 0 1
R:R:F289 R:R:W286 5.01 2 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 7.02 2 Yes Yes 7 8 2 2
R:R:F289 R:R:F290 4.29 2 Yes Yes 6 7 1 2
R:R:F289 R:R:N293 2.42 2 Yes No 6 5 1 1
R:R:F289 R:R:Y308 7.22 2 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 2.44 2 Yes No 6 5 1 2
R:R:F289 R:R:N312 13.29 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 2 Yes Yes 0 6 0 1
R:R:N293 R:R:Y308 9.3 2 No Yes 5 5 1 1
L:L:?1 R:R:N293 4.43 2 Yes No 0 5 0 1
R:R:K305 R:R:Y308 2.39 0 No Yes 2 5 2 1
L:L:?1 R:R:Y308 4.73 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 9.3 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 2 Yes No 0 5 0 1
R:R:W313 R:R:Y316 7.72 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.84 2 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.93
Average Nodes In Shell22.00
Average Hubs In Shell14.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO3 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP; Mg Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UO3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I169 R:R:T110 6.08 2 Yes Yes 5 4 2 2
R:R:F193 R:R:T110 10.38 2 Yes Yes 4 4 1 2
R:R:C116 R:R:D113 4.67 0 No Yes 7 7 2 1
R:R:D113 R:R:V117 4.38 2 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 12.64 2 Yes No 7 6 1 1
L:L:?1 R:R:D113 12.04 2 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 8.41 2 Yes No 0 5 0 1
R:R:F208 R:R:V117 3.93 2 Yes Yes 8 6 2 1
R:R:V117 R:R:W286 4.9 2 Yes Yes 6 8 1 2
L:L:?1 R:R:V117 4.81 2 Yes Yes 0 6 0 1
R:R:F193 R:R:I169 2.51 2 Yes Yes 4 5 1 2
R:R:F193 R:R:T195 3.89 2 Yes No 4 3 1 2
L:L:?1 R:R:F193 3.93 2 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No No 3 6 2 2
R:R:S203 R:R:Y199 7.63 0 No No 5 6 1 2
L:L:?1 R:R:S203 8.48 2 Yes No 0 5 0 1
R:R:F208 R:R:W286 18.04 2 Yes Yes 8 8 2 2
R:R:F208 R:R:F289 4.29 2 Yes Yes 8 6 2 1
R:R:F289 R:R:Y308 15.47 2 Yes Yes 6 5 1 1
R:R:F289 R:R:N312 6.04 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 2 Yes Yes 0 6 0 1
R:R:V292 R:R:Y308 7.57 0 No Yes 5 5 2 1
R:R:N293 R:R:Y308 10.47 0 No Yes 5 5 2 1
L:L:?1 R:R:Y308 2.84 2 Yes Yes 0 5 0 1
R:R:N312 R:R:Y316 19.77 2 No No 5 6 1 1
L:L:?1 R:R:N312 9.97 2 Yes No 0 5 0 1
L:L:?1 R:R:Y316 7.57 2 Yes No 0 6 0 1
R:R:S203 R:R:S204 1.63 0 No No 5 5 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.00
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO4 A Amine Adrenergic Beta2 Homo sapiens Epinephrine GTP; Mg Gs/Beta1/Gamma2 4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of G1I in 8UO4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C116 R:R:M82 9.73 2 No Yes 7 7 2 2
R:R:M82 R:R:V117 3.04 2 Yes Yes 7 6 2 1
R:R:M82 R:R:Y316 7.18 2 Yes Yes 7 6 2 1
R:R:V86 R:R:Y316 7.57 0 No Yes 7 6 2 1
R:R:F89 R:R:W109 22.05 0 No Yes 5 5 2 1
R:R:D113 R:R:W109 4.47 2 Yes Yes 7 5 1 1
R:R:F193 R:R:W109 32.07 2 No Yes 4 5 1 1
L:L:?1 R:R:W109 5.51 2 Yes Yes 0 5 0 1
R:R:I169 R:R:T110 3.04 0 No No 5 4 2 2
R:R:F193 R:R:T110 6.49 2 No No 4 4 1 2
R:R:C116 R:R:D113 4.67 2 No Yes 7 7 2 1
R:R:D113 R:R:V117 4.38 2 Yes Yes 7 6 1 1
R:R:D113 R:R:Y316 19.54 2 Yes Yes 7 6 1 1
L:L:?1 R:R:D113 5.47 2 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 4.85 0 No No 7 5 2 1
R:R:I169 R:R:V114 4.61 0 No No 5 5 2 1
L:L:?1 R:R:V114 9.62 2 Yes No 0 5 0 1
R:R:C116 R:R:V117 1.71 2 No Yes 7 6 2 1
R:R:I121 R:R:V117 3.07 2 Yes Yes 7 6 2 1
R:R:F208 R:R:V117 7.87 2 Yes Yes 8 6 1 1
R:R:V117 R:R:W286 6.13 2 Yes Yes 6 8 1 2
R:R:V117 R:R:Y316 2.52 2 Yes Yes 6 6 1 1
L:L:?1 R:R:V117 6.01 2 Yes Yes 0 6 0 1
R:R:S207 R:R:T118 6.4 2 No No 5 6 1 2
R:R:F208 R:R:I121 15.07 2 Yes Yes 8 7 1 2
L:L:?1 R:R:F193 6.88 2 Yes No 0 4 0 1
L:L:?1 R:R:S203 9.69 2 Yes No 0 5 0 1
R:R:F208 R:R:S207 9.25 2 Yes No 8 5 1 1
L:L:?1 R:R:S207 2.42 2 Yes No 0 5 0 1
R:R:F208 R:R:W286 10.02 2 Yes Yes 8 8 1 2
R:R:F208 R:R:F289 5.36 2 Yes Yes 8 6 1 1
R:R:F208 R:R:F290 2.14 2 Yes Yes 8 7 1 2
L:L:?1 R:R:F208 7.86 2 Yes Yes 0 8 0 1
R:R:F289 R:R:W286 8.02 2 Yes Yes 6 8 1 2
R:R:F289 R:R:N312 18.12 2 Yes No 6 5 1 1
L:L:?1 R:R:F289 12.77 2 Yes Yes 0 6 0 1
R:R:N312 R:R:Y316 11.63 2 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 2 Yes No 0 5 0 1
L:L:?1 R:R:Y316 4.73 2 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.46
Average Nodes In Shell23.00
Average Hubs In Shell11.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.72
Average Number Of Links With An Hub4.01
Average Interaction Strength8.02
Average Nodes In Shell22.30
Average Hubs In Shell11.29
Average Links In Shell32.52
Average Links Mediated by Hubs In Shell29.78

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)