Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 3.4754254
2A:A:R42 5.95409
3A:A:K53 6.385449
4A:A:H64 13.9754278
5A:A:I95 3.834117
6A:A:Y169 4.5145186
7A:A:Q170 3.9125439
8A:A:L171 4.6854188
9A:A:F178 4.013758117
10A:A:L179 3.1775407
11A:A:R199 6.4825117
12A:A:I207 2.5625429
13A:A:E209 5.9975429
14A:A:F219 5.148508
15A:A:H220 10.2625427
16A:A:F222 6.68667627
17A:A:W234 6.06409
18A:A:F238 5.2775429
19A:A:I244 3.482528
20A:A:I245 3.1225407
21A:A:F246 3.25333609
22A:A:Y253 4.75438
23A:A:N254 5.64333639
24A:A:M255 3.19438
25A:A:R265 4.77439
26A:A:L266 3.34538
27A:A:F273 4.735409
28A:A:W277 5.2625856
29A:A:L282 4.57429
30A:A:I288 2.7725409
31A:A:F290 4.265409
32A:A:N292 4.62449
33A:A:K293 5.885449
34A:A:I308 5.0325407
35A:A:F312 3.432508
36A:A:F315 11.2475406
37A:A:Y339 3.106553
38A:A:R342 5.70333654
39A:A:F345 4.66167638
40A:A:F363 5.992555
41A:A:R374 13.57754274
42A:A:I383 3.6354128
43A:A:R385 11.4554125
44A:A:Y391 4.49754134
45A:A:L394 3.685478
46B:B:L30 3.2375405
47B:B:I37 4.51402
48B:B:V40 3.6154303
49B:B:H54 7.35509
50B:B:K57 8.772529
51B:B:Y59 10428
52B:B:M61 3.314146
53B:B:W63 4.6425147
54B:B:R68 9.9725405
55B:B:V71 3.894218
56B:B:Q75 9.95429
57B:B:D76 4.7525259
58B:B:I80 6.45754248
59B:B:I81 2.85254217
60B:B:W82 6.9825249
61B:B:K89 4.2965249
62B:B:W99 5.79833629
63B:B:C103 2.15408
64B:B:Y105 3.443336216
65B:B:Y111 4.3775404
66B:B:L126 3.124215
67B:B:E138 4.6375406
68B:B:H142 8.2325499
69B:B:Y145 4.46408
70B:B:F151 4.6525409
71B:B:T159 4.942599
72B:B:S161 5.545499
73B:B:W169 9.77833698
74B:B:D170 4.15254319
75B:B:F180 5.4165167
76B:B:H183 7.2475409
77B:B:L190 2.76405
78B:B:F199 3.9765169
79B:B:C204 3.864517
80B:B:K209 8.8954166
81B:B:W211 7.4545168
82B:B:F222 5.61518
83B:B:H225 5.81625819
84B:B:D228 5.31419
85B:B:I232 3.92667618
86B:B:F235 5.316586
87B:B:P236 4.96487
88B:B:F241 4.79616
89B:B:T243 4.172518
90B:B:D247 6.5125419
91B:B:T249 3.686516
92B:B:R251 10.1467618
93B:B:F253 5.81616
94B:B:D254 2.488509
95B:B:L255 3.96416
96B:B:R256 5.5154229
97B:B:D258 6.202517
98B:B:E260 8.0975416
99B:B:L261 3.12405
100B:B:Y264 3.67167685
101B:B:I269 2.60254154
102B:B:V276 2.16406
103B:B:F278 5.35487
104B:B:R283 6.7725309
105B:B:Y289 5.62833607
106B:B:N293 6.67254155
107B:B:N295 6.97254156
108B:B:K301 5.295405
109B:B:R304 5.15254155
110B:B:H311 5.926529
111B:B:N313 3.6475427
112B:B:R314 8.742528
113B:B:L318 3.2975406
114B:B:V320 2.935407
115B:B:W332 9.008529
116B:B:D333 5.124529
117B:B:K337 6.005426
118B:B:W339 7.37529
119G:G:R27 4.36418
120G:G:K32 6.1754225
121G:G:D48 6.09509
122G:G:L51 4.0125406
123G:G:N59 4.7065209
124G:G:P60 6.24209
125G:G:F61 3.955717208
126R:R:Y70 5.0554344
127R:R:M82 4.375407
128R:R:V86 3.162567
129R:R:F101 5.96405
130R:R:W109 4.4225465
131R:R:D113 6.745467
132R:R:L115 3.6975405
133R:R:I121 6.44254107
134R:R:Y132 6.32754378
135R:R:F139 5.23754266
136R:R:Y141 5.6254137
137R:R:I154 2.8575408
138R:R:W158 4.183336359
139R:R:Y174 4.4475405
140R:R:F194 6.4225401
141R:R:F208 9.19408
142R:R:Y219 3.355479
143R:R:Q229 7.24127
144R:R:T274 5.1525478
145R:R:F282 5.0125109
146R:R:W286 7.0956108
147R:R:F289 6.9825466
148R:R:F290 9.0675467
149R:R:N293 2.93465
150R:R:N318 7.6345109
151M:M:?1 5.911340
152L:L:?1 8.835860
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:L30 B:B:K89 12.86842.82NoYes059
2B:B:D76 B:B:K78 14.48214.15YesNo098
3A:A:L30 B:B:K78 13.5734.23NoNo058
4A:A:Y37 B:B:D76 19.8382.3YesYes2549
5A:A:R42 A:A:Y37 21.3728.23YesYes094
6A:A:K53 A:A:L45 65.12232.82YesNo098
7A:A:D223 A:A:K53 69.48896.91NoYes499
8A:A:D223 A:A:V224 69.39042.92NoNo499
9A:A:V224 A:A:W234 69.74557.36NoYes099
10A:A:F238 A:A:W234 86.8673.01YesYes099
11A:A:F222 A:A:H220 21.973711.31YesYes277
12A:A:H220 A:A:R42 22.09645.64YesYes079
13A:A:I245 A:A:L45 60.23925.71YesNo078
14A:A:F238 B:B:W99 1008.02YesYes299
15B:B:Q75 B:B:W99 84.43327.67YesYes299
16B:B:K57 B:B:Q75 47.225913.56YesYes299
17B:B:A56 B:B:K57 11.44634.82NoYes079
18B:B:A56 B:B:D76 11.22124.63NoYes079
19A:A:F222 A:A:L44 35.54246.09YesNo279
20A:A:I244 A:A:L44 58.68872.85YesNo289
21A:A:I244 A:A:L46 58.17334.28YesNo088
22A:A:F246 A:A:L46 58.13482.44YesNo098
23A:A:M255 A:A:R265 15.08522.48YesYes389
24A:A:M255 A:A:N254 10.06222.8YesYes389
25A:A:N254 A:A:Y253 17.58455.81YesYes398
26A:A:L266 A:A:Y253 41.54632.34YesYes388
27A:A:F345 A:A:L266 63.00392.44YesYes388
28A:A:F345 A:A:V248 22.83636.55YesNo087
29A:A:F246 A:A:V248 23.34212.62YesNo097
30A:A:K300 A:A:M255 10.04982.88NoYes398
31A:A:K300 A:A:Y253 10.88562.39NoYes398
32A:A:F273 A:A:F345 25.76424.29YesYes098
33A:A:F246 A:A:F273 33.14125.36YesYes099
34A:A:F345 A:A:L289 22.97012.44YesNo089
35A:A:F246 A:A:L289 30.48933.65YesNo099
36A:A:K53 M:M:?1 12.732511.22YesYes490
37A:A:F290 A:A:I245 30.29032.51YesYes097
38A:A:R232 A:A:W234 29.24438NoYes089
39A:A:L272 A:A:R232 29.029210.93NoNo088
40B:B:C204 B:B:D186 27.60024.67YesNo079
41B:B:D186 B:B:Y145 27.87214.6NoYes098
42B:B:L117 B:B:Y145 59.84753.52NoYes098
43B:B:L117 B:B:W99 60.08312.28NoYes099
44B:B:C204 B:B:D228 26.22496.22YesYes179
45B:B:K57 B:B:W332 36.61915.8YesYes299
46A:A:F290 A:A:I288 28.49273.77YesYes099
47A:A:I288 A:A:N377 27.85411.42YesNo094
48A:A:I245 A:A:N377 27.97821.42YesNo074
49A:A:A337 A:A:V301 13.33681.7NoNo087
50A:A:A337 A:A:I308 15.00281.62NoYes087
51A:A:I308 A:A:Y253 12.59528.46YesYes078
52A:A:F312 A:A:I308 12.49073.77YesYes087
53A:A:F312 A:A:L266 20.76054.87YesYes088
54A:A:F273 A:A:W277 12.68473.01YesYes096
55A:A:G353 A:A:W277 11.78772.81NoYes046
56A:A:D354 A:A:G353 11.54511.68NoNo034
57A:A:D354 A:A:G355 10.4321.68NoNo032
58A:A:G355 A:A:R389 10.21644.5NoNo024
59A:A:R389 A:A:Y358 10.048.23NoNo044
60A:A:H362 A:A:I288 55.50432.65NoYes099
61A:A:H362 A:A:R380 55.329813.54NoNo097
62A:A:I383 A:A:R380 55.16232.51YesNo087
63A:A:I383 R:R:Q229 53.15095.49YesYes1287
64A:A:L388 R:R:E225 60.91616.63NoNo085
65R:R:E225 R:R:Q229 61.40998.92NoYes057
66A:A:L388 R:R:I135 60.39319.99NoNo1389
67A:A:Y391 R:R:I135 60.17364.84YesNo1349
68A:A:Y391 R:R:R131 58.68156.17YesNo049
69A:A:E392 R:R:R131 58.43199.3NoNo069
70A:A:E392 R:R:I278 55.96568.2NoNo768
71B:B:D228 B:B:D246 25.68963.99YesNo199
72B:B:D246 B:B:S227 25.42722.94NoNo196
73B:B:S227 B:B:S245 21.4373.26NoNo169
74B:B:H225 B:B:S245 21.170312.55YesNo199
75B:B:F253 B:B:H225 14.06913.39YesYes169
76B:B:F222 B:B:F253 10.40137.5YesYes186
77B:B:R283 G:G:L51 40.43523.64YesYes096
78B:B:I37 B:B:R283 35.62755.01YesYes029
79B:B:I37 B:B:L300 31.76782.85YesNo026
80B:B:L300 B:B:T34 30.80612.95NoNo065
81B:B:L30 B:B:T34 30.32512.95YesNo055
82B:B:L30 B:B:M262 22.53215.65YesNo054
83B:B:M45 B:B:N340 11.06172.8NoNo049
84B:B:L308 B:B:M45 11.94444.24NoNo074
85B:B:L308 B:B:W339 13.759812.53NoYes079
86B:B:N313 B:B:W332 68.35324.52YesYes279
87B:B:D333 B:B:N313 67.8284.04YesYes297
88B:B:H54 B:B:S74 16.01758.37YesNo099
89B:B:C121 B:B:T159 12.69633.38NoYes089
90B:B:C121 B:B:C149 12.91161.82NoNo088
91B:B:C149 B:B:T102 13.13126.76NoNo088
92B:B:G115 B:B:T102 13.3541.82NoNo098
93B:B:M101 B:B:Y145 17.77347.18NoYes098
94B:B:G116 B:B:M101 17.49725.24NoNo099
95B:B:S147 B:B:Y145 18.76322.54NoYes098
96B:B:S147 B:B:S160 18.48283.26NoNo096
97B:B:M262 B:B:Y264 21.55485.99NoYes845
98B:B:L318 B:B:T329 48.15174.42YesNo068
99B:B:L284 G:G:L51 43.02164.15NoYes056
100B:B:L284 B:B:V296 43.46042.98NoNo055
101B:B:L286 B:B:V296 43.9032.98NoNo075
102B:B:H311 B:B:T329 55.92394.11YesNo098
103R:R:I278 R:R:Y219 55.8424.84NoYes789
104R:R:A128 R:R:Y219 54.04942.67NoYes789
105R:R:A128 R:R:V218 53.84551.7NoNo086
106R:R:I214 R:R:V218 51.54813.07NoNo066
107R:R:C125 R:R:I214 51.29166.55NoNo076
108R:R:C125 R:R:P211 51.03481.88NoNo078
109R:R:I121 R:R:P211 50.52043.39YesNo078
110R:R:I121 R:R:W286 36.801211.74YesYes1078
111R:R:V117 R:R:W286 21.28812.45NoYes068
112L:L:?1 R:R:V117 21.01847.21YesNo006
113L:L:?1 R:R:D113 15.791912.04YesYes607
114R:R:F282 R:R:I121 13.20327.54YesYes1097
115R:R:F282 R:R:L124 10.85652.44YesNo098
116R:R:F208 R:R:W286 13.09563.01YesYes088
117R:R:F208 R:R:F290 11.663520.36YesYes087
118B:B:D333 B:B:H311 65.67725.04YesYes299
119B:B:G115 B:B:G116 17.22932.11NoNo099
120B:B:L286 B:B:L318 45.1772.77NoYes076
121B:B:D76 B:B:S74 16.19375.89YesNo099
122A:A:F222 B:B:W99 23.56889.02YesYes279
123B:B:Q75 B:B:Y59 36.486714.65YesYes298
124A:A:F238 A:A:L44 23.26723.65YesNo299
125A:A:F246 A:A:L272 28.97772.44YesNo098
126B:B:W332 B:B:Y59 36.065.79YesYes298
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V86 R:R:W109 3.68 6 Yes Yes 7 5 2 2
R:R:D113 R:R:V86 5.84 6 Yes Yes 7 7 1 2
R:R:D113 R:R:W109 3.35 6 Yes Yes 7 5 1 2
R:R:D113 R:R:Y316 5.75 6 Yes No 7 6 1 1
L:L:?1 R:R:D113 12.04 6 Yes Yes 0 7 0 1
R:R:S165 R:R:V114 8.08 0 No No 7 5 2 1
L:L:?1 R:R:V114 9.62 6 Yes No 0 5 0 1
R:R:V117 R:R:W286 2.45 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 6 Yes No 0 6 0 1
R:R:F193 R:R:Y308 7.22 6 No No 4 5 1 1
L:L:?1 R:R:F193 8.84 6 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 6 Yes No 0 5 0 1
R:R:F289 R:R:Y308 6.19 6 Yes No 6 5 2 1
R:R:F289 R:R:N312 9.67 6 Yes No 6 5 2 1
L:L:?1 R:R:Y308 4.73 6 Yes No 0 5 0 1
R:R:N312 R:R:Y316 23.26 6 No No 5 6 1 1
L:L:?1 R:R:N312 12.19 6 Yes No 0 5 0 1
L:L:?1 R:R:Y316 7.57 6 Yes No 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
88.89Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
80.00Single8GGTEpinephrine8GGT-β2-Epinephrine
80.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
77.78Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
77.78Single8GH1Epinephrine8GH1-β2-Epinephrine
72.73Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
70.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
70.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
70.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
70.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8GGVEpinephrine8GGV-β2-Epinephrine
70.00Single8GGWEpinephrine8GGW-β2-Epinephrine
70.00Single8GGXEpinephrine8GGX-β2-Epinephrine
70.00Single8GH0Epinephrine8GH0-β2-Epinephrine
70.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
66.67Single7XKAEpinephrine7XKA-β2-Epinephrine
66.67Single8GGREpinephrine8GGR-β2-Epinephrine
66.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
66.67Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
63.64Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
63.64Single6PS4ICI 118-5516PS4-β2-ICI 118-551
63.64Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
63.64Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGIEpinephrine8GGI-β2-Epinephrine
63.64Single8GGQEpinephrine8GGQ-β2-Epinephrine
63.64Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
62.50Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
61.54Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
60.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
60.00Single8GGSEpinephrine8GGS-β2-Epinephrine
60.00Single8GGYEpinephrine8GGY-β2-Epinephrine
60.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
60.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single2Y04Salbutamol2Y04-β1-Salbutamol
58.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
58.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
58.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
58.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
58.33Single6H7MSalbutamol6H7M-β1-Salbutamol
58.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
58.33Single6PS1Timolol6PS1-β2-Timolol
58.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
58.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
58.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
58.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
58.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
58.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
58.33Single8GGNEpinephrine8GGN-β2-Epinephrine
58.33Single8GGOEpinephrine8GGO-β2-Epinephrine
58.33Single8GGUEpinephrine8GGU-β2-Epinephrine
58.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
58.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
58.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
58.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
57.14Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8JJ8Formoterol8JJ8-β2-Formoterol
57.14Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
55.56Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
55.56Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
54.55Single6KUXRS-799486KUX-α2a-RS-79948
54.55Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
54.55Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
54.55Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
54.55Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
54.55Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8IWESpermidine8IWE-TAAR9-Spermidine
54.55Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
54.55Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
54.55Consensusalpha1_onOrthosteric Ligandalpha1a_on
54.55Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
54.55Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
54.55Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.85Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
53.85Single2Y03Isoprenaline2Y03-β1-Isoprenaline
53.85Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
53.85Single5C1MBU725C1M-μ-BU72
53.85Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
53.85Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
53.85Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
53.85Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
53.85Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
53.85Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
53.85Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
53.85Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
53.85Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
53.85Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
53.85Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
53.85Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
53.85Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
53.85Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
53.85Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
53.85Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
53.85Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.85Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
53.85Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
53.85Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
53.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
53.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
50.00Single2YDVNECA2YDV-A2A-NECA
50.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
50.00Single3P0GBI1671073P0G-β2-BI167107
50.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
50.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
50.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
50.00Single4UG2CGS216804UG2-A2A-CGS21680
50.00Single4UHRCGS216804UHR-A2A-CGS21680
50.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
50.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
50.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
50.00Single5G53NECA5G53-A2A-NECA-Gs
50.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
50.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
50.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
50.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
50.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
50.00Single6VI4JDTic6VI4-κ-JDTic
50.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
50.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
50.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
50.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGKEpinephrine8GGK-β2-Epinephrine
50.00Single8GGMEpinephrine8GGM-β2-Epinephrine
50.00Single8GGPEpinephrine8GGP-β2-Epinephrine
50.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
50.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
50.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
50.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
50.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
50.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
50.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
50.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
50.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single4IARErgotamine4IAR-5-HT1B-Ergotamine
47.06Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
46.67Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
46.67Single4AMIBucindolol4AMI-β1-Bucindolol
46.67Single4LDEBI1671074LDE-β2-BI167107
46.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
46.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
46.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
46.67Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
46.67Single6MXTSalmeterol6MXT-β2-Salmeterol
46.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
46.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
46.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single7YITNalfurafine7YIT-κ-Nalfurafine
46.67Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
46.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
46.67Single8JJLOlodaterol8JJL-β2-Olodaterol
46.67Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
46.67Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
46.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
46.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
46.67Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
46.15Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
46.15Single2Y01Dobutamine2Y01-β1-Dobutamine
46.15Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
46.15Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
46.15Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
46.15Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
46.15Single4EJ4Naltrindole4EJ4-δ-Naltrindole
46.15Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.15Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
46.15Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
46.15Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
46.15Single7BU7BI1671077BU7-β1-BI167107
46.15Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.15Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
46.15Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
46.15Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
46.15Single7UL4Alvimopan7UL4-μ-Alvimopan
46.15Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7WC7Lisuride7WC7-5-HT2A-Lisuride
46.15Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
46.15Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
46.15Single8JJOAlprenolol8JJO-β2-Alprenolol
46.15Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
46.15Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
46.15Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.15Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
46.15Consensusadenosine_onOrthosteric Liganda1_on a2_on
46.15Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
46.15Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
46.15Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
46.15Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
46.15Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
46.15Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
46.15Consensusgi_hcarOrthosteric Ligandgi_hca
46.15Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
46.15Consensusnucleotide_onOrthosteric Ligandadenosine_on
46.15Consensustar_onOrthosteric Ligandta1_on
45.45Single3PBLEticlopride3PBL-D3-Eticlopride
45.45Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
45.45Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
45.45Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
45.45Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
45.45Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
45.45Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
45.45Single8K5BNiacin8K5B-HCA2-Niacin
45.45Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
43.75Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
43.75Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
43.75Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
43.75Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
43.75Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
43.75Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
43.75Single6H7LDobutamine6H7L-β1-Dobutamine
43.75Single6IBLArformoterol6IBL-β1-Arformoterol
43.75Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
43.75Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
43.75Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
42.86Single2Y00Dobutamine2Y00-β1-Dobutamine
42.86Single5TVNLSD5TVN-5-HT2B-LSD
42.86Single5WIUNemonapride5WIU-D4-Nemonapride
42.86Single5WIVNemonapride5WIV-D4-Nemonapride-Na
42.86Single6E67BI1671076E67-β2-BI167107-Gs (fused)
42.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.86Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
42.86Single6PS6Timolol6PS6-β2-Timolol
42.86Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
42.86Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
42.86Single7WC6LSD7WC6-5-HT2A-LSD
42.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
42.86Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
42.86Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
42.86Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
42.86Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
42.86Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
42.86Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
42.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.86Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
42.86Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
42.86Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
42.11Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
41.67Single6AKXA4R6AKX-CCR5-A4R
41.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
41.67Single6B73PubChem 1319551386B73-κ-PubChem 131955138
41.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
41.67Single6TODEMPA6TOD-OX1-EMPA-Na
41.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
41.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
41.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
41.67Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.67Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
41.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
41.67Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
41.67Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.67Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single6PT3DPI-2876PT3-δ-DPI-287
41.18Single7XN9L-054,5227XN9-SST2-L-054,522
41.18Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
41.18Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
41.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
40.00Single4DJHJDTic4DJH-κ-JDTic
40.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
40.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.00Single4U15Tiotropium4U15-M3-Tiotropium
40.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
40.00Single5XR8AM8415XR8-CB1-AM841
40.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6J21Aprepitant6J21-NK1-Aprepitant
40.00Single6OL9Tiotropium6OL9-M5-Tiotropium
40.00Single6WGTLSD6WGT-5-HT2A-LSD
40.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
40.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
40.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
40.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
40.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
40.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
40.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
40.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
40.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
40.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
40.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
40.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
40.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
40.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
40.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
40.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
40.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
40.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
40.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
40.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
40.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
40.00Consensushistamine_offOrthosteric Ligandh1_off
40.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
40.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
40.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
40.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
40.00Consensussensory_onOrthosteric Ligandopsin_on
38.89Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
38.89Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.89Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
38.89Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
38.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
38.89Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
38.89Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.46Single2YDOAdenosine2YDO-A2A-Adenosine
38.46Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
38.46Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.46Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.46Single4ZJCSB-6740424ZJC-OX1-SB-674042
38.46Single6A94Zotepine6A94-5-HT2A-Zotepine
38.46Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
38.46Single6TPGEMPA6TPG-OX2-EMPA
38.46Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
38.46Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
38.46Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
38.46Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.46Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
38.46Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
38.46Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
38.46Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.46Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
38.46Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
38.46Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8GGLEpinephrine8GGL-β2-Epinephrine
38.46Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
38.46Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
38.46Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
38.46Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
38.46Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
38.46Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
38.46Single8K5CAcipimox8K5C-HCA2-Acipimox
38.46Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
38.46Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
38.46Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Consensus5ht5_onOrthosteric Ligand5ht5a_on
38.46Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
38.46Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
38.46Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.46Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
38.46Consensushca_onOrthosteric Ligandhca2_on hca3_on
38.46Consensushcar_onOrthosteric Ligandhca_on
38.46Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
38.46Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
38.10Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
38.10Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
37.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
37.50Single5CXVTiotropium5CXV-M1-Tiotropium
37.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
37.50Single6A93Risperidone6A93-5-HT2A-Risperidone
37.50Single6CM4Risperidone6CM4-D2-Risperidone
37.50Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
37.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
37.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
37.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
37.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.50Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
37.50Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
37.50Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
37.50Single8WU1KCA8WU1-CB1-KCA-Arrestin1
37.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
37.50Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
37.50Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
37.50Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
37.50Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
37.50Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
37.50Consensusgs_steroidOrthosteric Ligandgs_bileacid
37.50Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
37.50Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
37.50Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Single3QAKUK-4320973QAK-A2A-UK-432097
36.84Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
36.84Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
36.84Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
36.84Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.36Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
36.36Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
36.36Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
36.36Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single2Y02Carmoterol2Y02-β1-Carmoterol
35.71Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
35.71Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
35.71Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single4YAYZD-71554YAY-AT1-ZD-7155
35.71Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
35.71Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
35.71Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
35.71Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
35.71Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
35.71Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
35.71Single6TOTLemborexant6TOT-OX1-Lemborexant
35.71Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.71Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
35.71Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
35.71Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
35.71Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
35.71Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
35.71Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
35.71Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
35.71Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
35.71Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
35.71Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
35.71Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
35.71Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
35.71Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.71Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.71Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
35.71Single8K5DGSK2560738K5D-HCA2-GSK256073
35.71Single8X64Desloratadine8X64-H1-Desloratadine
35.71Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
35.71Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
35.71Consensusblt_onOrthosteric Ligandblt1_on
35.71Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
35.71Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
35.71Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
35.71Consensushistamine_onOrthosteric Ligandh1_on h4_on
35.71Consensusleuko_onOrthosteric Ligandblt_on
35.71Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
35.71Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
35.29Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.29Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
35.29Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
35.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
35.29Single7EZCUKA7EZC-A2A-UKA
35.29Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
35.29Single7UM4AS26747237UM4-5-HT5A-AS2674723
35.29Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
35.29Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
35.29Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
35.29Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
35.29Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
35.29Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
35.29Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.29Consensusendothelin_offOrthosteric Ligandetb_off
35.29Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
35.29Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusorexin_onOrthosteric Ligandox2_on
35.29Consensussteroid_onOrthosteric Ligandbileacid_on
35.00Single5WF5UK-4320975WF5-A2A-UK-432097
35.00Single6PT2KGCHM076PT2-δ-KGCHM07
35.00Consensusangiotensin_onOrthosteric Ligandat1_on
35.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
35.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single5WQCEMPA5WQC-OX2-EMPA
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Single6HLLCP999946HLL-NK1-CP99994
33.33Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
33.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single6TP6Filorexant6TP6-OX1-Filorexant
33.33Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
33.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
33.33Single7SK9CCX6627SK9-ACKR3-CCX662
33.33Single7SRQLSD7SRQ-5-HT2B-LSD
33.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
33.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
33.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
33.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8X5YAstemizole8X5Y-H1-Astemizole
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
33.33Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
33.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
31.82Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.58Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
31.58Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.58Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
31.58Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.58Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
31.58Consensussst_onOrthosteric Ligandsst2_on sst4_on
31.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
31.25Single5X93K-87945X93-ETB-K-8794
31.25Single5XRAAM115425XRA-CB1-AM11542
31.25Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
31.25Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Single6TQ7SB-3348676TQ7-OX1-SB-334867
31.25Single7B6WCyclazosin7B6W-α1b-Cyclazosin
31.25Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
31.25Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.25Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
31.25Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
31.25Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
31.25Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
31.25Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
31.25Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.25Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
31.25Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
31.25Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
31.25Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
31.25Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
31.25Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
31.25Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
31.25Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
31.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.25Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
31.25Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
31.25Consensuscck_onOrthosteric Ligandccka_on cckb_on
31.25Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.25Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
31.25Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
31.25Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
30.77Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
30.77Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
30.77Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
30.77Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
30.77Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
30.77Single5DHHSB-6121115DHH-NOP-SB-612111
30.77Single5WS3EMPA5WS3-OX2-EMPA
30.77Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
30.77Single6ME2Ramelteon6ME2-MT1-Ramelteon
30.77Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.77Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
30.77Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
30.77Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
30.77Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
30.77Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
30.77Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
30.77Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
30.77Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
30.77Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.77Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
30.77Single8IHKAcifran8IHK-HCA3-Acifran
30.77Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
30.77Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgt_class-aOrthosteric Ligandgt_opsin
30.77Consensusgt_opsinOrthosteric Ligandgt_sensory
30.77Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
30.77Consensusorexin_offOrthosteric Ligandox2_off ox1_off
30.43Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
30.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
30.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
30.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
30.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.00Single6HLOAprepitant6HLO-NK1-Aprepitant
30.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
30.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
30.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
30.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
30.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.41Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
29.41Single6ZG4HTL00099366ZG4-M1-HTL0009936
29.41Single7DFPSpiperone7DFP-D2-Spiperone
29.41Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
29.41Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.41Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
29.41Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.41Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
29.41Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
29.41Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
29.41Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
29.41Consensusdp_offOrthosteric Liganddp2_off
29.41Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
29.41Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
29.41Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
29.41Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.41Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
28.57Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
28.57Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
28.57Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
28.57Single6DS0Ly2660976DS0-5-HT2B-Ly266097
28.57Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.57Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
28.57Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
28.57Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
28.57Single6TPNHTL66416TPN-OX2-HTL6641
28.57Single6V9SGTPL114036V9S-OX1-GTPL11403
28.57Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
28.57Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
28.57Single6ZG9GSK10347026ZG9-M1-GSK1034702
28.57Single7AROLUF58337ARO-A2A-LUF5833-Na
28.57Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
28.57Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
28.57Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
28.57Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
28.57Single7T32ZM2413857T32-A2A-ZM241385
28.57Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.57Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
28.57Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
28.57Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
28.57Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
28.57Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
28.57Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
28.57Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
28.57Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
28.57Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
28.57Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
28.57Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
28.57Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
28.57Consensuss1p_offOrthosteric Ligands1p1_off
28.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.00Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
27.78Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
27.78Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
27.78Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
27.78Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
27.78Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
27.78Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
27.78Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
27.78Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
27.78Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
27.78Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.78Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
27.78Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
27.78Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.78Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
27.78Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
27.27Single3RFMCaffeine3RFM-A2A-Caffeine
27.27Single6JODAngiotensin II6JOD-AT2-Angiotensin II
27.27Single6TQ9SB-4081246TQ9-OX1-SB-408124
27.27Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
27.27Single8A2OTheophylline8A2O-A2A-Theophylline-Na
27.27Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.27Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
26.67Single4DAJTiotropium4DAJ-M3-Tiotropium
26.67Single4MQSIperoxo4MQS-M2-Iperoxo
26.67Single4U14Tiotropium4U14-M3-Tiotropium
26.67Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
26.67Single5DSGTiotropium5DSG-M4-Tiotropium
26.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.67Single5UENDU1725UEN-A1-DU172
26.67Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
26.67Single6D27CAY104716D27-DP2-CAY10471
26.67Single6DRXLisuride6DRX-5-HT2B-Lisuride
26.67Single6GPSMK08126GPS-CCR2-MK0812
26.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
26.67Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
26.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.67Single8CU6LJ-45178CU6-A2A-LJ-4517
26.67Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
26.67Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
26.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.67Single8X63Mepyramine8X63-H1-Mepyramine
26.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.67Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
26.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
26.67Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Single5ZTYAM102575ZTY-CB2-AM10257
26.32Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.32Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
26.32Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
26.32Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
26.32Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.32Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.32Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.32Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.32Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
26.32Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.32Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.09Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
26.09Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
26.09Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
26.09Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
26.09Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single3UZAGTPL92363UZA-A2A-GTPL9236
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
25.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F8XNN90567F8X-CCKA-NN9056
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
25.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
25.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
25.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8QOTNanobody E8QOT-μ-Nanobody E
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
24.14Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
24.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
24.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
24.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.00Consensusgo_class-b1Orthosteric Ligandgo_crf
24.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.81Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
23.81Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
23.81Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.53Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
23.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.53Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
23.53Single6J20Aprepitant6J20-NK1-Aprepitant
23.53Single7EPENAM5637EPE-mGlu-NAM563
23.53Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
23.53Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.53Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
23.53Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.53Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.53Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
23.53Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
23.53Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.53Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.53Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
23.53Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.53Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
23.53Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
23.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Consensuschemerin_onOrthosteric Ligandcml1_on
23.53Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
23.53Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.53Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.53Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.53Consensuslpa_offOrthosteric Ligandlpa1_off
23.53Consensuslpa_onOrthosteric Ligandlpa1_on
23.53Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.53Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.53Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.53Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.53Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.33Consensuspth_onOrthosteric Ligandpth1_on pth2_on
23.08Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.08Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
23.08Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
23.08Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
23.08Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
23.08Single3OE9IT1t3OE9-CXCR4-IT1t
23.08Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.08Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.08Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
23.08Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
23.08Single6IGLIRL16206IGL-ETB-IRL1620
23.08Single6LMLGlucagon6LML-Glucagon-Glucagon
23.08Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.08Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.08Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
23.08Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.08Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
23.08Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
23.08Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.08Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
23.08Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
23.08Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
22.73Single3OE0CVX153OE0-CXCR4-CVX15
22.73Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
22.73Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
22.73Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
22.73Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
22.73Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
22.73Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
22.73Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
22.73Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.22Single5GLHEndothelin-15GLH-ETB-Endothelin-1
22.22Single6HLPNetupitant6HLP-NK1-Netupitant
22.22Single6IGKEndothelin-36IGK-ETB-Endothelin-3
22.22Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
22.22Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
22.22Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.22Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
22.22Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
22.22Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.22Single7K15MKD0467K15-BLT1-MKD046-Na
22.22Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.22Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
22.22Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
22.22Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.22Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.22Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
22.22Single8JWZAB9288JWZ-A2A-AB928-Na
22.22Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
22.22Consensusgi_class-fOther Ligandgi_frizzled
22.22Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.22Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.22Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
22.22Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
21.88Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
21.88Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.74Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
21.74Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.74Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.74Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.74Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
21.43Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.43Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.43Single3PWHZM2413853PWH-A2A-ZM241385
21.43Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.43Single5K2DZM2413855K2D-A2A-ZM241385
21.43Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.43Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.43Single6JZHZM2413856JZH-A2A-ZM241385-Na
21.43Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.43Single6PS7ZM2413856PS7-A2A-ZM241385-Na
21.43Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
21.43Single7F8ULintitript7F8U-CCKA-Lintitript
21.43Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.43Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.43Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.43Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.43Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
21.43Single7XRRLemborexant7XRR-OX2-Lemborexant
21.43Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
21.43Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
21.43Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
21.43Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.43Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.43Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
21.43Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.43Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
21.43Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.43Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
21.43Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Consensusglp_onOrthosteric Ligandglp1_on glp2_on
21.43Consensusmglu_onOther Ligandmglu2_on mglu4_on
21.43Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
21.05Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.05Single5CGDHTL142425CGD-mGlu5-HTL14242
21.05Single6K1QIRL25006K1Q-ETB-IRL2500
21.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
21.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
21.05Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.05Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
21.05Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
21.05Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
21.05Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.83Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.83Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
20.83Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.83Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
20.83Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.83Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.83Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.83Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.83Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.83Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.83Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.83Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.83Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.69Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.69Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.69Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
20.00Single3REYPubChem 56973REY-A2A-PubChem 5697
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single4XT3Fractalkine4XT3-US28-Fractalkine
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
20.00Single6AQFZM2413856AQF-A2A-ZM241385
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6MH8ZM2413856MH8-A2A-ZM241385
20.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.00Consensusclass-d_offOrthosteric Ligandste2_off
20.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
20.00Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.00Consensussensory_offOrthosteric Ligandopsin_off
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.35Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
19.23Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
19.23Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
19.23Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
19.23Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
19.23Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.23Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
19.23Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.23Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.23Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.23Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.05Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.05Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
19.05Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
19.05Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
19.05Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.05Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.75Single3EMLZM2413853EML-A2A-ZM241385
18.75Single4EIYZM2413854EIY-A2A-ZM241385-Na
18.75Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.75Single5K2AZM2413855K2A-A2A-ZM241385-Na
18.75Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
18.75Single5OLGZM2413855OLG-A2A-ZM241385-Na
18.75Single5TGZAM65385TGZ-CB1-AM6538
18.75Single5VRAZM2413855VRA-A2A-ZM241385-Na
18.75Single6IIVDaltroban6IIV-TP-Daltroban
18.75Single6LPJZM2413856LPJ-A2A-ZM241385-Na
18.75Single6LPKZM2413856LPK-A2A-ZM241385-Na
18.75Single6S0LZM2413856S0L-A2A-ZM241385
18.75Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.75Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
18.75Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.75Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.75Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
18.75Single7PYRPSB-21157PYR-A2A-PSB-2115
18.75Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
18.75Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
18.75Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
18.75Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.75Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
18.75Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
18.75Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
18.75Consensushcar_offOrthosteric Ligandsuccinate_off
18.75Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
18.75Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
18.75Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.75Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
18.75Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.75Consensustachykinin_offOrthosteric Ligandnk1_off
18.75Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.52Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.52Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.52Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.52Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.52Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.52Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.52Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.18Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.18Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.18Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.18Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.18Single7SK5CXCL127SK5-ACKR3-CXCL12
18.18Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.18Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
18.18Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.18Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.18Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8PWNTheophylline8PWN-A2A-Theophylline
18.18Consensussst_offOrthosteric Ligandsst2_off
17.86Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.86Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.65Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.65Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.65Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
17.65Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.65Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.65Single6LPLZM2413856LPL-A2A-ZM241385-Na
17.65Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.65Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
17.65Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.65Single6S0QZM2413856S0Q-A2A-ZM241385
17.65Single6WQAZM2413856WQA-A2A-ZM241385-Na
17.65Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.65Single7RM5ZM2413857RM5-A2A-ZM241385-Na
17.65Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.65Single8FYNZM2413858FYN-A2A-ZM241385-Na
17.65Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
17.65Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.65Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.65Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
17.65Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
17.65Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.65Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.65Consensusep_offOrthosteric Ligandep4_off
17.65Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single6W25SHU91196W25-MC4-SHU9119-Ca
17.39Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
17.39Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.39Single7XNACYN1548067XNA-SST2-CYN154806
17.39Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.39Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.24Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6E59L-7607356E59-NK1-L-760735
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Single7P2L4YI7P2L-mGlu5-4YI
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.13Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.13Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
16.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.79Single4N4WSANT-14N4W-SMO-SANT-1
15.79Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.79Single5X33BIIL2605X33-BLT1-BIIL260
15.79Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.79Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.79Single6IIURamatroban6IIU-TP-Ramatroban
15.79Single6OS2TRV0266OS2-AT1-TRV026
15.79Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.79Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.79Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.79Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.79Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.62Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
15.62Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.38Single3OE6IT1t3OE6-CXCR4-IT1t
15.38Single3OE8IT1t3OE8-CXCR4-IT1t
15.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.38Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
15.38Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
15.38Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.38Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
15.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.81Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.81Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.81Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
14.81Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.81Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
14.29Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.29Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single6TP4ACT-4622066TP4-OX1-ACT-462206
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
14.29Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.29Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
14.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.29Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
14.29Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
14.29Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IY6Endothelin-18IY6-ETB-Endothelin-1
14.29Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusclass-t_onOrthosteric Ligandtaste2_on
14.29Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.29Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.29Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_class-tOrthosteric Ligandgs_taste
14.29Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.29Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.29Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.29Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.79Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.64Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.64Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.64Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.64Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
13.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.33Single3ODUIT1t3ODU-CXCR4-IT1t
13.33Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
13.33Single5U09Taranabant5U09-CB1-Taranabant
13.33Single5ZKQABT-4915ZKQ-PAF-ABT-491
13.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
13.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
13.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
13.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
13.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
13.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
13.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.33Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.33Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.33Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
13.04Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.04Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.04Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
12.90Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single5UVIZM2413855UVI-A2A-ZM241385
12.50Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.50Single6TPKRetosiban6TPK-OT-Retosiban
12.50Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
12.50Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.50Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
12.50Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
12.50Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.50Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
12.50Single7VODCariprazine7VOD-5-HT2A-Cariprazine
12.50Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
12.50Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
12.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
12.50Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
12.50Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
12.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.50Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
12.50Consensusclass-c_offOther Ligandgabab_off mglu_off
12.50Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
12.50Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
12.50Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.50Consensusgnrh_offOrthosteric Ligandgnrh1_off
12.50Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.50Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
12.50Consensusvasopressin-ot_offOrthosteric Ligandot_off
12.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
12.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
12.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
12.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
12.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.76Single6FFHFenobam6FFH-mGlu5-Fenobam
11.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.76Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.76Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.76Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.76Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.76Consensuscck_offOrthosteric Ligandccka_off
11.76Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.76Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.54Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.54Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
11.11Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
11.11Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7SK3CXCL127SK3-ACKR3-CXCL12
11.11Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.11Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
11.11Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.53Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.53Single6OS1TRV0266OS1-AT1-TRV026
10.53Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.53Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.53Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.53Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.53Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.53Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.53Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.53Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.53Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.53Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.53Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.53Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.34Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
10.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
10.00Single4XESNeurotensin4XES-NTS1-Neurotensin
10.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
10.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
10.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
10.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
10.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
10.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
10.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
10.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
10.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
10.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
10.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.00Consensusnts_offOrthosteric Ligandnts1_off
10.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.68Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.52Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.52Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.52Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.52Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.52Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.52Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.52Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusgs_class-b2Orthosteric Ligandgs_adgr
9.09Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.70Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.70Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.57Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.33Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7SHEPI; PE7SHE-GPR158-PI; PE
8.33Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
8.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusclass-c_onOther Ligandgabab_on mglu_on
8.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.69Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.69Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.69Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
7.14Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.14Single4XNWMRS25004XNW-P2Y1-MRS2500
7.14Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.14Single6LI0GTPL98046LI0-GPR52-GTPL9804
7.14Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.14Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.14Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
7.14Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.14Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
7.14Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.90Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Single7UL2SR486927UL2-NTS1-SR48692-Na
6.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.67Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
6.67Consensusgo_proteinOrthosteric Ligandgo_chemokine
6.67Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.67Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.25Single4BWBNeurotensin4BWB-NTS1-Neurotensin
6.25Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.25Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
6.25Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
6.25Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.25Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
6.25Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.25Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.88Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.88Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88Single6ZINSR486926ZIN-NTS1-SR48692
5.88Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
5.88Single8IYXYL-3658IYX-GPR34-YL-365
5.88Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
5.88Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.56Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.56Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.56Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.56Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
5.56Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
5.56Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
5.56Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.56Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
5.56Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
5.56Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.26Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.26Single6Z4SSR486926Z4S-NTS1-SR48692
5.26Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.26Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
5.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
5.00Single5V56TC1145V56-SMO-TC114
5.00Single5V57TC1145V57-SMO-TC114
5.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
5.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
5.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
5.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.76Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.76Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7SHEPI; PE7SHE-GPR158-PI; PE
4.76Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Consensuschemokine_offOrthosteric Ligandcxcr_off
4.76Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.76Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.76Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.76Consensusnts_onOrthosteric Ligandnts1_on
4.55Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.55Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.55Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.55Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.55Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.17Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.12Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.12Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.03Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.94Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.94Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.70Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.50Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.50Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8GGC
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand Epinephrine
Other Ligand(s) GTP
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.4
Date 2024-03-06
D.O.I. 10.1038/s41586-024-07153-1
Net Summary
Imin 2.28
Number of Linked Nodes 872
Number of Links 1039
Number of Hubs 152
Number of Links mediated by Hubs 565
Number of Communities 38
Number of Nodes involved in Communities 248
Number of Links involved in Communities 332
Path Summary
Number Of Nodes in MetaPath 127
Number Of Links MetaPath 126
Number of Shortest Paths 1498505
Length Of Smallest Path 3
Average Path Length 30.0148
Length of Longest Path 73
Minimum Path Strength 1.1
Average Path Strength 5.20591
Maximum Path Strength 23.695
Minimum Path Correlation 0.71
Average Path Correlation 0.986965
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 51.1176
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1159
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeGTP
PDB ResiduesM:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeGTP
NameGuanosine-5'-Triphosphate
SynonymsGuanosine-5'-Triphosphate
Identifier[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
FormulaC10 H16 N5 O14 P3
Molecular Weight523.18
SMILESc1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
PubChem5280317
Formal Charge0
Total Atoms48
Total Chiral Atoms4
Total Bonds50
Total Aromatic Bonds5

CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8GGC_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKSTI 
VKQMRILHV VQDIKNNLK EAIETIVAA MVRACYERS NEYQLIDCA 
QYFLDQDLL RCRVLTSGI FETKFQVDK VNFHMFDVG GQRDERRKW 
IQCFNDVTA IIFVVASSS YNMVIREDN QTNRLQEAL NLFKSIWNN 
RWLRTISVI LFLNKQDLL AEKVLAGKS KIEDYFPEF ARYTTPEDA 
TPEPEDPRV TRAKYFIRD EFLRISTAS GDGRHYCYP HFTCAVDTE 
NIRRVFNDC RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8GGC_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8GGC_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GGC_Chain_R
VWVVGMGIV MSLIVLAIV FGNVLVIQT VTNYFITSL ACADLVMGL 
AVVPFGAAH ILTKTWTFG NFWCEFWTS IDVLCVTAS IETLCVIAV 
DRYFAITSP FKYQSLLTK NRVIILMVW IVSGLTSFL PIQMHWYRH 
QEAINCYAE ECDFFTNQA YAIASSIVS FYVPLVIMV FVYSRVFQE 
AKRQLQKID KHKALKTLG IIMGTFTLC WLPFFIVNI VHVIQDNLI 
RKEVYILLN WIGYVNSGF NIYC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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