psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M22	4.43	Yes	No	0	0	3
2	L:L:?1	R:R:G23	3.22	Yes	No	1	0	8
3	L:L:?1	R:R:D72	3.4	Yes	No	1	0	9
4	L:L:?1	R:R:L79	8.67	Yes	No	0	0	6
5	L:L:?1	R:R:S80	4.7	Yes	No	0	0	8
6	L:L:?1	R:R:M112	4.43	Yes	Yes	1	0	8
7	L:L:?1	R:R:F115	11.45	Yes	No	0	0	8
8	L:L:?1	R:R:S119	3.76	Yes	No	0	0	8
9	L:L:?1	R:R:R310	15.99	Yes	Yes	1	0	9
10	L:L:?1	R:R:S313	23.52	Yes	No	0	0	9
11	L:L:?1	R:R:S316	10.35	Yes	No	1	0	8
12	R:R:F5	R:R:Y6	14.44	Yes	Yes	2	4	6
13	R:R:F5	R:R:V188	6.55	Yes	No	0	4	3
14	R:R:F5	R:R:H189	16.97	Yes	Yes	2	4	4
15	R:R:F5	R:R:K296	11.17	Yes	No	2	4	1
16	R:R:E302	R:R:F5	3.5	Yes	Yes	2	3	4
17	R:R:V175	R:R:Y6	6.31	No	Yes	2	4	6
18	R:R:Y177	R:R:Y6	6.95	Yes	Yes	2	9	6
19	R:R:Q186	R:R:Y6	9.02	No	Yes	2	5	6
20	R:R:K16	R:R:R7	6.19	No	No	0	1	4
21	R:R:K296	R:R:R7	9.9	No	No	0	1	4
22	R:R:N297	R:R:R7	4.82	No	No	0	3	4
23	R:R:C8	R:R:K16	6.47	No	No	5	9	1
24	R:R:C178	R:R:C8	7.28	No	No	5	4	9
25	R:R:N10	R:R:Q9	13.2	No	Yes	4	6	2
26	R:R:Q9	R:R:R94	5.84	Yes	Yes	4	2	2
27	R:R:N102	R:R:Q9	6.6	Yes	Yes	4	1	2
28	R:R:Q176	R:R:Q9	3.84	No	Yes	4	5	2
29	R:R:N10	R:R:R94	4.82	No	Yes	4	6	2
30	R:R:N10	R:R:N102	5.45	No	Yes	4	6	1
31	R:R:T12	R:R:V95	4.76	No	No	0	5	2
32	R:R:N90	R:R:V14	4.43	No	No	0	5	4
33	R:R:G180	R:R:V14	3.68	No	No	0	6	4
34	R:R:E15	R:R:N90	5.26	No	No	0	3	5
35	R:R:C178	R:R:K16	3.23	No	No	5	4	1
36	R:R:G17	R:R:N18	3.39	No	Yes	1	3	3
37	R:R:G17	R:R:P179	6.09	No	No	1	3	8
38	R:R:N18	R:R:P179	3.26	Yes	No	1	3	8
39	R:R:N18	R:R:R310	3.62	Yes	Yes	1	3	9
40	R:R:I317	R:R:L26	4.28	No	No	0	9	8
41	R:R:F27	R:R:L31	3.65	No	No	0	8	6
42	R:R:F27	R:R:S80	9.25	No	No	0	8	8
43	R:R:T29	R:R:W321	3.64	No	No	0	6	8
44	R:R:G30	R:R:K76	3.49	No	Yes	0	9	8
45	R:R:G33	R:R:W321	5.63	No	No	0	9	8
46	R:R:N34	R:R:T69	2.92	Yes	No	0	9	8
47	R:R:L73	R:R:N34	9.61	No	Yes	1	8	9
48	R:R:K76	R:R:N34	8.39	Yes	Yes	1	8	9
49	R:R:N34	R:R:P320	16.29	Yes	No	0	9	9
50	R:R:A37	R:R:I324	3.25	No	No	0	9	9
51	R:R:L40	R:R:R327	9.72	No	No	0	8	9
52	R:R:F323	R:R:L41	6.09	Yes	No	0	9	9
53	R:R:S59	R:R:Y62	3.82	No	No	0	7	7
54	R:R:F61	R:R:M126	3.73	Yes	Yes	0	9	9
55	R:R:F61	R:R:R130	10.69	Yes	Yes	3	9	9
56	R:R:F61	R:R:L266	3.65	Yes	No	0	9	8
57	R:R:F61	R:R:L267	8.53	Yes	No	3	9	9
58	R:R:L146	R:R:M63	4.24	No	No	0	4	6
59	R:R:A150	R:R:M63	4.83	No	No	0	5	6
60	R:R:L64	R:R:M126	7.07	No	Yes	0	8	9
61	R:R:L64	R:R:V152	4.47	No	No	0	8	5
62	R:R:M126	R:R:V65	3.04	Yes	No	0	9	8
63	R:R:L68	R:R:Q122	6.65	No	No	0	9	7
64	R:R:L68	R:R:N319	4.12	No	No	0	9	9
65	R:R:Q122	R:R:T71	9.92	No	No	0	7	9
66	R:R:D72	R:R:K76	4.15	No	Yes	1	9	8
67	R:R:D72	R:R:S316	8.83	No	No	1	9	8
68	R:R:K76	R:R:L73	4.23	Yes	No	1	8	8
69	R:R:F115	R:R:G75	9.03	No	No	0	8	9
70	R:R:F108	R:R:L79	3.65	Yes	No	0	6	6
71	R:R:P81	R:R:S80	3.56	No	No	0	8	8
72	R:R:A86	R:R:T181	3.36	No	No	0	6	9
73	R:R:Q89	R:R:R91	3.5	No	No	0	5	3
74	R:R:R91	R:R:V95	5.23	No	No	0	3	2
75	R:R:S92	R:R:V95	4.85	No	No	0	5	2
76	R:R:L93	R:R:R94	3.64	Yes	Yes	0	6	2
77	R:R:L104	R:R:L93	6.92	No	Yes	0	5	6
78	R:R:L93	R:R:T181	8.84	Yes	No	0	6	9
79	R:R:C183	R:R:L93	3.17	No	Yes	0	9	6
80	R:R:N102	R:R:R94	19.28	Yes	Yes	4	1	2
81	R:R:C105	R:R:R94	5.57	No	Yes	0	9	2
82	R:R:Q176	R:R:R94	12.85	No	Yes	4	5	2
83	R:R:A97	R:R:L96	3.15	No	No	0	1	4
84	R:R:F174	R:R:N102	3.62	No	Yes	0	6	1
85	R:R:C105	R:R:F174	5.59	No	No	0	9	6
86	R:R:C105	R:R:C183	7.28	No	No	0	9	9
87	R:R:P167	R:R:Q106	3.16	No	No	0	9	4
88	R:R:F174	R:R:Q106	25.77	No	No	0	6	4
89	R:R:F108	R:R:W182	5.01	Yes	Yes	0	6	9
90	R:R:F110	R:R:F111	12.86	No	No	0	7	5
91	R:R:C164	R:R:F110	4.19	No	No	0	8	7
92	R:R:M112	R:R:W182	4.65	Yes	Yes	1	8	9
93	R:R:L309	R:R:M112	5.65	No	Yes	1	7	8
94	R:R:C164	R:R:S113	3.44	No	No	0	8	7
95	R:R:F184	R:R:S113	5.28	Yes	No	0	8	7
96	R:R:S113	R:R:Y203	5.09	No	No	0	7	8
97	R:R:F114	R:R:F115	7.5	Yes	No	0	7	8
98	R:R:F114	R:R:S118	3.96	Yes	Yes	6	7	7
99	R:R:F114	R:R:S157	5.28	Yes	No	6	7	6
100	R:R:F114	R:R:L161	3.65	Yes	No	0	7	3
101	R:R:L117	R:R:S160	9.01	No	No	0	8	7
102	R:R:F163	R:R:L117	3.65	No	No	0	7	8
103	R:R:S118	R:R:V156	3.23	Yes	No	0	7	6
104	R:R:S118	R:R:S157	4.89	Yes	No	6	7	6
105	R:R:S118	R:R:S160	4.89	Yes	No	0	7	7
106	R:R:S119	R:R:T120	3.2	No	No	0	8	7
107	R:R:F274	R:R:S119	6.61	No	No	0	9	8
108	R:R:M207	R:R:T120	3.01	No	No	0	7	7
109	R:R:L121	R:R:V156	5.96	No	No	0	5	6
110	R:R:L121	R:R:L210	4.15	No	No	0	5	6
111	R:R:L123	R:R:T214	2.95	No	No	3	8	8
112	R:R:L123	R:R:T271	5.9	No	Yes	3	8	8
113	R:R:F274	R:R:L123	7.31	No	No	0	9	8
114	R:R:L124	R:R:L210	4.15	No	No	0	5	6
115	R:R:L124	R:R:T214	4.42	No	No	0	5	8
116	R:R:A125	R:R:V152	3.39	No	No	0	7	5
117	R:R:M126	R:R:M270	4.33	Yes	No	0	9	9
118	R:R:A127	R:R:N218	4.69	No	No	0	9	9
119	R:R:R130	R:R:S133	5.27	Yes	No	0	9	9
120	R:R:E260	R:R:R130	3.49	No	Yes	0	9	9
121	R:R:H136	R:R:W131	3.17	Yes	No	0	4	6
122	R:R:A221	R:R:W131	3.89	No	No	0	9	6
123	R:R:H136	R:R:L132	3.86	Yes	No	0	4	5
124	R:R:S133	R:R:Y140	10.17	No	No	0	9	8
125	R:R:L134	R:R:N224	9.61	No	No	0	8	7
126	R:R:G135	R:R:H136	3.18	No	Yes	0	7	4
127	R:R:G135	R:R:N224	3.39	No	No	0	7	7
128	R:R:F139	R:R:H136	9.05	No	Yes	0	5	4
129	R:R:F138	R:R:R141	12.83	No	No	7	7	6
130	R:R:F138	R:R:R142	5.34	No	Yes	7	7	5
131	R:R:F139	R:R:R142	5.34	No	Yes	0	5	5
132	R:R:I144	R:R:Y140	9.67	No	No	0	5	8
133	R:R:R141	R:R:R142	4.26	No	Yes	7	6	5
134	R:R:H143	R:R:R142	10.16	No	Yes	0	5	5
135	R:R:L148	R:R:T145	2.95	No	No	0	5	6
136	R:R:F163	R:R:L202	4.87	No	No	0	7	5
137	R:R:G172	R:R:P167	4.06	No	No	0	8	9
138	R:R:F171	R:R:K173	12.41	No	No	0	4	2
139	R:R:F171	R:R:S195	5.28	No	No	0	4	1
140	R:R:G172	R:R:Y199	4.35	No	No	0	8	6
141	R:R:K173	R:R:Q186	6.78	No	No	0	2	5
142	R:R:K173	R:R:Y199	3.58	No	No	0	2	6
143	R:R:V175	R:R:Y177	5.05	No	Yes	2	4	9
144	R:R:Q186	R:R:V175	15.76	No	No	2	5	4
145	R:R:G180	R:R:Q176	3.29	No	No	0	6	5
146	R:R:F184	R:R:Y177	8.25	Yes	Yes	0	8	9
147	R:R:M187	R:R:Y177	3.59	No	Yes	0	7	9
148	R:R:D305	R:R:Y177	19.54	No	Yes	2	7	9
149	R:R:P179	R:R:W182	5.4	No	Yes	1	8	9
150	R:R:L306	R:R:W182	3.42	No	Yes	1	7	9
151	R:R:L309	R:R:W182	5.69	No	Yes	1	7	9
152	R:R:R310	R:R:W182	3	Yes	Yes	1	9	9
153	R:R:F184	R:R:I185	10.05	Yes	No	0	8	7
154	R:R:F184	R:R:L309	12.18	Yes	No	0	8	7
155	R:R:I185	R:R:Y199	6.04	No	No	0	7	6
156	R:R:I185	R:R:Y203	3.63	No	No	0	7	8
157	R:R:M187	R:R:S200	3.07	No	No	0	7	7
158	R:R:M187	R:R:R284	4.96	No	Yes	0	7	5
159	R:R:R284	R:R:V188	3.92	Yes	No	0	5	3
160	R:R:E191	R:R:H189	17.23	No	Yes	2	1	4
161	R:R:H189	R:R:K294	14.41	Yes	No	2	4	1
162	R:R:E190	R:R:S193	8.62	No	No	8	1	3
163	R:R:E190	R:R:V196	15.69	No	No	8	1	5
164	R:R:E191	R:R:K294	10.8	No	No	2	1	1
165	R:R:S193	R:R:V196	4.85	No	No	8	3	5
166	R:R:L197	R:R:V196	2.98	No	No	0	4	5
167	R:R:L197	R:R:S200	3	No	No	0	4	7
168	R:R:M207	R:R:Y203	7.18	No	No	0	7	8
169	R:R:I282	R:R:S204	9.29	No	No	0	8	8
170	R:R:A285	R:R:S204	3.42	No	No	0	7	8
171	R:R:S204	R:R:Y286	5.09	No	No	0	8	5
172	R:R:S205	R:R:Y286	5.09	No	No	0	4	5
173	R:R:L206	R:R:L210	4.15	No	No	0	5	6
174	R:R:I282	R:R:M207	2.92	No	No	0	8	7
175	R:R:T275	R:R:V211	7.93	No	No	0	5	8
176	R:R:T214	R:R:T271	4.71	No	Yes	3	8	8
177	R:R:L267	R:R:N218	4.12	No	No	3	9	9
178	R:R:N218	R:R:T271	10.24	No	Yes	3	9	8
179	R:R:L225	R:R:L264	5.54	No	No	0	9	7
180	R:R:R230	R:R:Y226	9.26	No	No	0	5	5
181	R:R:H229	R:R:R230	5.64	No	No	10	6	5
182	R:R:H229	R:R:Q233	8.65	No	No	10	6	3
183	R:R:Q233	R:R:R230	3.5	No	No	10	3	5
184	R:R:E259	R:R:E260	6.34	No	No	0	6	9
185	R:R:L261	R:R:L265	4.15	No	No	9	5	6
186	R:R:D262	R:R:R332	8.34	No	No	0	9	6
187	R:R:F326	R:R:L266	4.87	No	No	0	5	8
188	R:R:L267	R:R:T271	2.95	No	Yes	3	9	8
189	R:R:M270	R:R:N319	4.21	No	No	0	9	9
190	R:R:L273	R:R:V318	4.47	No	No	0	8	8
191	R:R:F274	R:R:I315	3.77	No	No	0	9	9
192	R:R:M276	R:R:T275	6.02	No	No	0	5	5
193	R:R:C277	R:R:I315	3.27	No	No	0	9	9
194	R:R:I282	R:R:S278	3.1	No	No	0	8	9
195	R:R:P280	R:R:Y283	5.56	No	No	0	9	6
196	R:R:A308	R:R:V281	3.39	No	No	0	7	8
197	R:R:E304	R:R:Y283	4.49	No	No	0	1	6
198	R:R:E302	R:R:R284	4.65	Yes	Yes	2	3	5
199	R:R:E304	R:R:R284	19.77	No	Yes	0	1	5
200	R:R:D305	R:R:R284	14.29	No	Yes	2	7	5
201	R:R:F290	R:R:Y286	3.09	No	No	0	3	5
202	R:R:K291	R:R:Y287	14.33	No	No	0	3	4
203	R:R:D292	R:R:K294	13.83	No	No	0	2	1
204	R:R:R298	R:R:V293	5.23	No	No	0	1	1
205	R:R:E302	R:R:K296	8.1	Yes	No	2	3	1
206	R:R:N297	R:R:S300	4.47	No	No	0	3	1
207	R:R:D305	R:R:E302	3.9	No	Yes	2	7	3
208	R:R:L306	R:R:R310	8.5	No	Yes	1	7	9
209	R:R:I317	R:R:V314	3.07	No	No	0	9	4
210	R:R:N319	R:R:P320	4.89	No	No	0	9	9
211	R:R:F323	R:R:R327	6.41	Yes	No	0	9	9
212	R:R:S328	R:R:V330	3.23	No	No	0	7	7
213	R:R:F331	R:R:V330	5.24	No	No	0	7	7
214	R:R:F339	R:R:I338	8.79	No	No	0	5	4
215	R:R:F311	R:R:P280	2.89	No	No	0	6	9
216	R:R:I144	R:R:L132	2.85	No	No	0	5	5
217	R:R:L26	R:R:M22	2.83	No	No	0	8	3
218	R:R:L312	R:R:M112	2.83	No	Yes	0	8	8
219	R:R:L219	R:R:M222	2.83	No	No	0	5	7
220	R:R:G220	R:R:W131	2.81	No	No	0	5	6
221	R:R:C77	R:R:F27	2.79	No	No	0	6	8
222	R:R:L31	R:R:L35	2.77	No	No	0	6	5
223	R:R:A37	R:R:F323	2.77	No	Yes	0	9	9
224	R:R:A263	R:R:F61	2.77	No	Yes	3	8	9
225	R:R:A263	R:R:R130	2.77	No	Yes	3	8	9
226	R:R:E129	R:R:L128	2.65	No	No	0	9	7
227	R:R:F108	R:R:V82	2.62	Yes	No	0	6	6
228	R:R:F108	R:R:V83	2.62	Yes	No	0	6	9
229	R:R:H336	R:R:L258	2.57	No	No	0	4	6
230	R:R:H336	R:R:L261	2.57	No	No	0	4	5
231	R:R:V60	R:R:Y140	2.52	No	No	0	7	8
232	R:R:F331	R:R:I325	2.51	No	No	0	7	8
233	R:R:I333	R:R:R332	2.51	No	No	0	5	6
234	R:R:F334	R:R:I333	2.51	No	No	0	4	5
235	R:R:F335	R:R:I338	2.51	No	No	0	4	4
236	R:R:F323	R:R:L266	2.44	Yes	No	0	9	8
237	L:L:?1	R:R:G116	2.14	Yes	No	0	0	8
238	R:R:G23	R:R:G24	2.11	No	No	1	8	4
239	R:R:C66	R:R:G67	1.96	No	No	0	6	6
240	R:R:A42	R:R:G47	1.95	No	No	0	4	5
241	R:R:A97	R:R:P98	1.87	No	No	0	1	5
242	R:R:A153	R:R:P154	1.87	No	No	0	7	4
243	R:R:G45	R:R:S44	1.86	No	No	0	6	7
244	R:R:G149	R:R:V60	1.84	No	No	0	7	7
245	R:R:G67	R:R:V70	1.84	No	No	0	6	5
246	R:R:G149	R:R:V152	1.84	No	No	0	7	5
247	R:R:G288	R:R:V188	1.84	No	No	0	7	3
248	R:R:G30	R:R:T29	1.82	No	No	0	9	6
249	R:R:A109	R:R:C183	1.81	No	No	0	8	9
250	R:R:A127	R:R:C217	1.81	No	No	0	9	7
251	R:R:P4	R:R:S3	1.78	No	No	0	6	6
252	R:R:P329	R:R:S328	1.78	No	No	0	7	7
253	R:R:G23	R:R:L84	1.71	No	No	1	8	7
254	R:R:G24	R:R:L84	1.71	No	No	1	4	7
255	R:R:G33	R:R:L32	1.71	No	No	0	9	4
256	R:R:G33	R:R:L36	1.71	No	No	0	9	5
257	R:R:G39	R:R:L38	1.71	No	No	0	3	7
258	R:R:A99	R:R:S103	1.71	No	No	0	5	3
259	R:R:A289	R:R:V201	1.7	No	No	0	7	4
260	R:R:C8	R:R:T11	1.69	No	No	0	9	4
261	R:R:C66	R:R:T69	1.69	No	No	0	6	8
262	R:R:L166	R:R:P167	1.64	No	No	0	7	9
263	R:R:E190	R:R:G192	1.64	No	No	0	1	1
264	R:R:L279	R:R:P280	1.64	No	No	0	7	9
265	R:R:S92	R:R:V14	1.62	No	No	0	5	4
266	R:R:S28	R:R:V25	1.62	No	No	0	4	4
267	R:R:S205	R:R:V201	1.62	No	No	0	4	4
268	R:R:S278	R:R:V281	1.62	No	No	0	9	8
269	R:R:S13	R:R:T11	1.6	No	No	0	1	4
270	R:R:S28	R:R:T29	1.6	No	No	0	4	6
271	R:R:V211	R:R:V215	1.6	No	No	0	8	6
272	R:R:C217	R:R:L128	1.59	No	No	0	7	7
273	R:R:T271	R:R:V215	1.59	Yes	No	0	8	6
274	R:R:C277	R:R:L273	1.59	No	No	0	9	8
275	R:R:A86	R:R:L96	1.58	No	No	0	6	4
276	R:R:A99	R:R:L104	1.58	No	No	0	5	5
277	R:R:A213	R:R:L124	1.58	No	No	0	6	5
278	R:R:A150	R:R:L151	1.58	No	No	0	5	3
279	R:R:I322	R:R:V318	1.54	No	No	0	8	8
280	R:R:H189	R:R:P4	1.53	Yes	No	0	4	6
281	R:R:H136	R:R:P137	1.53	Yes	No	0	4	9
282	R:R:M63	R:R:V60	1.52	No	No	0	6	7
283	R:R:A153	R:R:Q122	1.52	No	No	0	7	7
284	R:R:M276	R:R:V272	1.52	No	No	0	5	5
285	R:R:K291	R:R:V293	1.52	No	No	0	3	1
286	R:R:L194	R:R:S195	1.5	No	No	0	1	1
287	R:R:G220	R:R:R223	1.5	No	No	0	5	4
288	R:R:L38	R:R:V70	1.49	No	No	0	7	5
289	R:R:L74	R:R:V70	1.49	No	No	0	4	5
290	R:R:L212	R:R:V211	1.49	No	No	0	3	8
291	R:R:L219	R:R:V215	1.49	No	No	0	5	6
292	R:R:G288	R:R:Y287	1.45	No	No	0	7	4
293	R:R:P329	R:R:R332	1.44	No	No	0	7	6
294	R:R:L232	R:R:M228	1.41	No	No	0	5	8
295	R:R:L134	R:R:L225	1.38	No	No	0	8	9
296	R:R:L206	R:R:L209	1.38	No	No	0	5	3
297	R:R:L261	R:R:L264	1.38	No	No	9	5	7
298	R:R:L264	R:R:L265	1.38	No	No	9	7	6
299	R:R:A303	R:R:R307	1.38	No	No	0	1	4
300	R:R:F61	R:R:S59	1.32	Yes	No	0	9	7
301	R:R:R147	R:R:T145	1.29	No	No	0	4	6
302	R:R:R298	R:R:T299	1.29	No	No	0	1	1
303	R:R:S19	R:R:Y87	1.27	No	No	0	6	8
304	R:R:F159	R:R:L121	1.22	No	No	0	4	5
305	R:R:F159	R:R:L206	1.22	No	No	0	4	5
306	R:R:D262	R:R:F326	1.19	No	No	0	9	5
307	R:R:N18	R:R:Y87	1.16	Yes	No	0	3	8
308	R:R:E301	R:R:R298	1.16	No	No	0	3	1
309	R:R:F334	R:R:F335	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.005	12	1	0
2	R:R:F5	10.526	5	2	4
3	R:R:Y6	9.18	4	2	6
4	R:R:Q9	7.37	4	4	2
5	R:R:N18	2.8575	4	1	3
6	R:R:N34	9.3025	4	1	9
7	R:R:F61	5.115	6	3	9
8	R:R:K76	5.065	4	1	8
9	R:R:L93	5.6425	4	0	6
10	R:R:R94	8.66667	6	4	2
11	R:R:N102	8.7375	4	4	1
12	R:R:F108	3.475	4	0	6
13	R:R:M112	4.39	4	1	8
14	R:R:F114	5.0975	4	6	7
15	R:R:S118	4.2425	4	6	7
16	R:R:M126	4.5425	4	0	9
17	R:R:R130	5.555	4	3	9
18	R:R:H136	4.158	5	0	4
19	R:R:R142	6.275	4	7	5
20	R:R:Y177	8.676	5	2	9
21	R:R:W182	4.52833	6	1	9
22	R:R:F184	8.94	4	0	8
23	R:R:H189	12.535	4	2	4
24	R:R:T271	5.078	5	3	8
25	R:R:R284	9.518	5	2	5
26	R:R:E302	5.0375	4	2	3
27	R:R:R310	7.7775	4	1	9
28	R:R:F323	4.4275	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M112	89.74	4.43	Yes	Yes	1	0	8
2	R:R:L309	R:R:M112	87.8531	5.65	No	Yes	1	7	8
3	R:R:F184	R:R:L309	100	12.18	Yes	No	0	8	7
4	R:R:F184	R:R:Y177	88.1608	8.25	Yes	Yes	0	8	9
5	R:R:Y177	R:R:Y6	28.8315	6.95	Yes	Yes	2	9	6
6	R:R:F5	R:R:Y6	36.5892	14.44	Yes	Yes	2	4	6
7	R:R:F5	R:R:V188	13.0493	6.55	Yes	No	0	4	3
8	R:R:M187	R:R:Y177	28.5341	3.59	No	Yes	0	7	9
9	R:R:M187	R:R:R284	19.1355	4.96	No	Yes	0	7	5
10	R:R:R284	R:R:V188	18.4126	3.92	Yes	No	0	5	3
11	R:R:D305	R:R:Y177	30.3492	19.54	No	Yes	2	7	9
12	R:R:D305	R:R:R284	17.7409	14.29	No	Yes	2	7	5
13	R:R:F5	R:R:H189	10.5779	16.97	Yes	Yes	2	4	4
14	R:R:F5	R:R:K296	14.0953	11.17	Yes	No	2	4	1
15	R:R:D305	R:R:E302	11.3726	3.9	No	Yes	2	7	3
16	R:R:E302	R:R:K296	10.5112	8.1	Yes	No	2	3	1
17	R:R:Q186	R:R:Y6	11.7623	9.02	No	Yes	2	5	6
18	R:R:K296	R:R:R7	21.9146	9.9	No	No	0	1	4
19	R:R:K16	R:R:R7	13.762	6.19	No	No	0	1	4
20	R:R:F184	R:R:I185	45.3366	10.05	Yes	No	0	8	7
21	R:R:I185	R:R:Y199	81.6233	6.04	No	No	0	7	6
22	R:R:G172	R:R:Y199	87.8788	4.35	No	No	0	8	6
23	R:R:G172	R:R:P167	86.9712	4.06	No	No	0	8	9
24	R:R:P167	R:R:Q106	85.1254	3.16	No	No	0	9	4
25	R:R:F174	R:R:Q106	84.2999	25.77	No	No	0	6	4
26	R:R:F174	R:R:N102	42.2653	3.62	No	Yes	0	6	1
27	R:R:N102	R:R:Q9	14.1004	6.6	Yes	Yes	4	1	2
28	R:R:N102	R:R:R94	25.7601	19.28	Yes	Yes	4	1	2
29	R:R:C105	R:R:F174	41.0809	5.59	No	No	0	9	6
30	R:R:C105	R:R:R94	25.8883	5.57	No	Yes	0	9	2
31	R:R:Q176	R:R:Q9	13.0185	3.84	No	Yes	4	5	2
32	R:R:Q176	R:R:R94	26.3959	12.85	No	Yes	4	5	2
33	R:R:G180	R:R:Q176	35.7125	3.29	No	No	0	6	5
34	R:R:G180	R:R:V14	31.7849	3.68	No	No	0	6	4
35	R:R:S92	R:R:V14	19.9405	1.62	No	No	0	5	4
36	R:R:S92	R:R:V95	15.9719	4.85	No	No	0	5	2
37	L:L:?1	R:R:S80	10.4856	4.7	Yes	No	0	0	8
38	L:L:?1	R:R:D72	37.0815	3.4	Yes	No	1	0	9
39	R:R:D72	R:R:K76	36.1739	4.15	No	Yes	1	9	8
40	R:R:G30	R:R:K76	13.6953	3.49	No	Yes	0	9	8
41	R:R:G30	R:R:T29	12.0187	1.82	No	No	0	9	6
42	R:R:K76	R:R:N34	26.8523	8.39	Yes	Yes	1	8	9
43	R:R:N34	R:R:T69	12.3058	2.92	Yes	No	0	9	8
44	R:R:N34	R:R:P320	20.2277	16.29	Yes	No	0	9	9
45	L:L:?1	R:R:S119	61.5341	3.76	Yes	No	0	0	8
46	R:R:F274	R:R:S119	99.8103	6.61	No	No	0	9	8
47	R:R:F274	R:R:L123	95.2264	7.31	No	No	0	9	8
48	R:R:L123	R:R:T271	86.8841	5.9	No	Yes	3	8	8
49	R:R:L267	R:R:T271	79.1776	2.95	No	Yes	3	9	8
50	R:R:F61	R:R:L267	80.3261	8.53	Yes	No	3	9	9
51	R:R:F61	R:R:L266	31.872	3.65	Yes	No	0	9	8
52	R:R:N319	R:R:P320	19.438	4.89	No	No	0	9	9
53	R:R:M270	R:R:N319	14.8541	4.21	No	No	0	9	9
54	R:R:M126	R:R:M270	14.1722	4.33	Yes	No	0	9	9
55	R:R:F61	R:R:M126	17.7819	3.73	Yes	Yes	0	9	9
56	R:R:F61	R:R:R130	48.5207	10.69	Yes	Yes	3	9	9
57	R:R:R130	R:R:S133	44.7213	5.27	Yes	No	0	9	9
58	R:R:S133	R:R:Y140	43.301	10.17	No	No	0	9	8
59	L:L:?1	R:R:F115	21.3403	11.45	Yes	No	0	0	8
60	R:R:L93	R:R:R94	23.9809	3.64	Yes	Yes	0	6	2
61	R:R:L93	R:R:T181	19.8636	8.84	Yes	No	0	6	9
62	R:R:A86	R:R:T181	15.9104	3.36	No	No	0	6	9
63	R:R:C105	R:R:C183	14.3516	7.28	No	No	0	9	9
64	R:R:C183	R:R:L93	11.8392	3.17	No	Yes	0	9	6
65	R:R:L104	R:R:L93	11.9469	6.92	No	Yes	0	5	6
66	R:R:A86	R:R:L96	11.9469	1.58	No	No	0	6	4
67	R:R:F184	R:R:S113	10.1728	5.28	Yes	No	0	8	7
68	R:R:S119	R:R:T120	49.5616	3.2	No	No	0	8	7
69	R:R:M207	R:R:T120	49.9308	3.01	No	No	0	7	7
70	R:R:M207	R:R:Y203	53.9917	7.18	No	No	0	7	8
71	R:R:F114	R:R:F115	18.1818	7.5	Yes	No	0	7	8
72	R:R:F114	R:R:S118	13.3364	3.96	Yes	Yes	6	7	7
73	R:R:L124	R:R:T214	12.716	4.42	No	No	0	5	8
74	R:R:I144	R:R:Y140	35.6919	9.67	No	No	0	5	8
75	R:R:I144	R:R:L132	34.1691	2.85	No	No	0	5	5
76	R:R:H136	R:R:L132	32.636	3.86	Yes	No	0	4	5
77	R:R:G135	R:R:H136	15.0951	3.18	No	Yes	0	7	4
78	R:R:G135	R:R:N224	13.439	3.39	No	No	0	7	7
79	R:R:L134	R:R:N224	11.7725	9.61	No	No	0	8	7
80	R:R:K173	R:R:Y199	16.0693	3.58	No	No	0	2	6
81	R:R:M187	R:R:S200	10.5779	3.07	No	No	0	7	7
82	R:R:I282	R:R:M207	22.9503	2.92	No	No	0	8	7
83	R:R:I282	R:R:S204	14.7464	9.29	No	No	0	8	8
84	R:R:S204	R:R:Y286	10.583	5.09	No	No	0	8	5
85	R:R:T271	R:R:V215	13.9004	1.59	Yes	No	0	8	6
86	R:R:L134	R:R:L225	10.0856	1.38	No	No	0	8	9
87	R:R:F326	R:R:L266	21.2429	4.87	No	No	0	5	8
88	R:R:D262	R:R:F326	19.7559	1.19	No	No	0	9	5
89	R:R:D262	R:R:R332	18.2639	8.34	No	No	0	9	6
90	R:R:E304	R:R:R284	16.5308	19.77	No	Yes	0	1	5
91	R:R:E304	R:R:Y283	13.2441	4.49	No	No	0	1	6
92	R:R:G288	R:R:V188	26.5908	1.84	No	No	0	7	3
93	R:R:G288	R:R:Y287	22.776	1.45	No	No	0	7	4
94	R:R:K291	R:R:Y287	18.9509	14.33	No	No	0	3	4
95	R:R:K291	R:R:V293	15.1156	1.52	No	No	0	3	1
96	R:R:R298	R:R:V293	11.2701	5.23	No	No	0	1	1
97	R:R:C66	R:R:T69	10.5779	1.69	No	No	0	6	8
98	R:R:L309	R:R:W182	12.1827	5.69	No	Yes	1	7	9
99	R:R:I185	R:R:Y203	48.2285	3.63	No	No	0	7	8
100	R:R:K173	R:R:Q186	12.3776	6.78	No	No	0	2	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:M22	4.43	1	Yes	No	0	3	0	1
L:L:?1	R:R:G23	3.22	1	Yes	No	0	8	0	1
L:L:?1	R:R:D72	3.4	1	Yes	No	0	9	0	1
L:L:?1	R:R:L79	8.67	1	Yes	No	0	6	0	1
L:L:?1	R:R:S80	4.7	1	Yes	No	0	8	0	1
L:L:?1	R:R:M112	4.43	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F115	11.45	1	Yes	No	0	8	0	1
L:L:?1	R:R:S119	3.76	1	Yes	No	0	8	0	1
L:L:?1	R:R:R310	15.99	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S313	23.52	1	Yes	No	0	9	0	1
L:L:?1	R:R:S316	10.35	1	Yes	No	0	8	0	1
R:R:N18	R:R:R310	3.62	1	Yes	Yes	3	9	2	1
R:R:F27	R:R:S80	9.25	0	No	No	8	8	2	1
R:R:D72	R:R:K76	4.15	1	No	Yes	9	8	1	2
R:R:D72	R:R:S316	8.83	1	No	No	9	8	1	1
R:R:F115	R:R:G75	9.03	0	No	No	8	9	1	2
R:R:F108	R:R:L79	3.65	0	Yes	No	6	6	2	1
R:R:P81	R:R:S80	3.56	0	No	No	8	8	2	1
R:R:F108	R:R:W182	5.01	0	Yes	Yes	6	9	2	2
R:R:M112	R:R:W182	4.65	1	Yes	Yes	8	9	1	2
R:R:L309	R:R:M112	5.65	1	No	Yes	7	8	2	1
R:R:F114	R:R:F115	7.5	6	Yes	No	7	8	2	1
R:R:S119	R:R:T120	3.2	0	No	No	8	7	1	2
R:R:F274	R:R:S119	6.61	0	No	No	9	8	2	1
R:R:L306	R:R:W182	3.42	1	No	Yes	7	9	2	2
R:R:L309	R:R:W182	5.69	1	No	Yes	7	9	2	2
R:R:R310	R:R:W182	3	1	Yes	Yes	9	9	1	2
R:R:L306	R:R:R310	8.5	1	No	Yes	7	9	2	1
R:R:L26	R:R:M22	2.83	0	No	No	8	3	2	1
R:R:L312	R:R:M112	2.83	0	No	Yes	8	8	2	1
L:L:?1	R:R:G116	2.14	1	Yes	No	0	8	0	1
R:R:G23	R:R:G24	2.11	1	No	No	8	4	1	2
R:R:G23	R:R:L84	1.71	1	No	No	8	7	1	2
R:R:G24	R:R:L84	1.71	1	No	No	4	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
71.43	Single	9EKH	ONO-3030297	9EKH-DP₁-ONO-3030297
50.00	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
47.37	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
47.37	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
45.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
44.44	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
44.44	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
42.11	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
42.11	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.11	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
42.11	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
42.11	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
41.18	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
41.18	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
41.18	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
41.18	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
41.18	Single	9JRT	TG6-129	9JRT-EP₂-TG6-129
40.00	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
40.00	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
38.89	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
38.89	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
38.89	Single	9RHG	C407	9RHG-FZD₇-C407
36.84	Single	6AK3	PGE2	6AK3-EP₃-PGE2
36.84	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
35.29	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
35.29	Single	9JRO	PF-04418948	9JRO-EP₂-PF-04418948
35.00	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
35.00	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00	Single	9M1H	PGE2	9M1H-EP₁-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
31.58	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
31.58	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
31.58	Single	9E9S	PGD2	9E9S-DP₁-PGD2-Gs/β1/γ1
30.00	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
30.00	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
30.00	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41	Single	6FFI	MPEP	6FFI-mGlu₅-MPEP
29.41	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
28.57	Single	7D7M	PGE2	7D7M-EP₄-PGE2-Gs/β1/γ1
28.57	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
27.78	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
27.78	Single	8GCM	L-902688	8GCM-EP₄-L-902688-Gi1/β1/γ2
27.78	Single	9JQZ	Grapiprant	9JQZ-EP₄-Grapiprant
26.32	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
26.32	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
26.32	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
26.32	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
26.32	Single	9HC0	4YI	9HC0-mGlu₅-4YI
26.32	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
26.32	Consensus	ep_off	Orthosteric Ligand	ep4_off
25.00	Single	7P2L	4YI	7P2L-mGlu₅-4YI
23.81	Single	9BJK	PubChem 171642066	9BJK-μ-Naloxone-PubChem 171642066
23.53	Single	5U09	Taranabant	5U09-CB₁-Taranabant
22.73	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
22.73	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
22.73	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
22.22	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
22.22	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
22.22	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
22.22	Single	9JQY	TG6-129	9JQY-EP₄-TG6-129
22.22	Single	9ODJ	Mitragynine Pseudoindoxyl	9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
22.22	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
21.74	Single	6PT3	DPI-287	6PT3-δ-DPI-287
21.74	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
21.43	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
21.43	Single	9JID	Niacin	9JID-HCA₃-Niacin-Gi1/β1/γ2
21.05	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
21.05	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
21.05	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
21.05	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
21.05	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
20.83	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
20.83	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
20.00	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
20.00	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
20.00	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.00	Single	8IWM	2-Phenylethylamine	8IWM-TAA9-2-Phenylethylamine
20.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
20.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
20.00	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
20.00	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
20.00	Single	8Z8A	Lactate	8Z8A-HCA₁-Lactate-Gi1/β1/γ2
20.00	Single	9B9Z	MRI-1867	9B9Z-CB₁-MRI-1867
20.00	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
19.05	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
19.05	Single	7U2L	C5-guano	7U2L-μ-C5-guano-Gi1/β1/γ2
19.05	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
19.05	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.75	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
18.75	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
18.75	Single	8IW7	2-Phenylethylamine	8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.75	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
18.75	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.75	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
18.75	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
18.75	Single	9JKT	(2R)-2-hydroxy-3-phenylpropanoic acid	9JKT-HCA₃-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
18.75	Single	9LRC	Histamine	9LRC-H₄-Histamine
18.75	Single	9LRE	Histamine	9LRE-H₄-Histamine-Gi1/β1/γ2
18.75	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
18.75	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
18.52	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.18	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
18.18	Single	6H7N	Xamoterol	6H7N-β₁-Xamoterol
18.18	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
18.18	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
18.18	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
18.18	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
18.18	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
17.65	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2
17.65	Single	7XKF	Dehydroepiandrosterone	7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
17.65	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
17.65	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
17.65	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
17.65	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
17.65	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
17.65	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
17.65	Single	8W89	2-Phenylethylamine	8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
17.65	Single	8YKD	Dehydroepiandrosterone	8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
17.65	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.65	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
17.65	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
17.65	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go/β1/γ2
17.65	Single	9B9Y	Taranabant	9B9Y-CB₁-Taranabant
17.65	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
17.65	Single	9IXJ	Histamine	9IXJ-H₂-Histamine-Gs/β1/γ2
17.65	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
17.65	Single	9JED	Histamine	9JED-H₄-Histamine-PO4-Gi1/β1/γ2
17.65	Single	9JEQ	Histamine	9JEQ-H₃-Histamine-Gi1/β1/γ2
17.65	Single	9L42	Histamine	9L42-H₄-Histamine-Gi1/β1/γ2
17.65	Single	9U9V	METH	9U9V-β₂-METH-Gs/β1/γ2
17.65	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
17.39	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
17.39	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
17.39	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
17.39	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
17.39	Single	9HYI	DP81	9HYI-5-HT_1A-DP81-Gi1/β1/γ2
17.39	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
17.39	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
16.67	Single	6AKX	A4R	6AKX-CCR5-A4R
16.67	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
16.67	Single	6B73	MP1104	6B73-κ-MP1104
16.67	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
16.67	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
16.67	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
16.67	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
16.67	Single	7EJ0	Norepinephrine	7EJ0-α_2a-Norepinephrine-Go/β1/γ2
16.67	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
16.67	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
16.67	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
16.67	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
16.67	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
16.67	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
16.67	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.67	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
16.67	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1
16.67	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
16.67	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
16.67	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
16.67	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
16.67	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
16.67	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
16.67	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
16.67	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
16.67	Single	8IW4	Spermidine	8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8IWE	Spermidine	8IWE-TAA9-Spermidine
16.67	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
16.67	Single	8TZQ	Dopamine	8TZQ-D₂-Dopamine-Go/β1/γ2
16.67	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
16.67	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
16.67	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
16.67	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go/β1/γ2
16.67	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ2
16.67	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
16.67	Single	8Z87	CHBA	8Z87-HCA₁-CHBA-Gi1/β1/γ2
16.67	Single	9JKX	Acifran	9JKX-HCA₃-Acifran-Gi1/β1/γ2
16.67	Single	9K6L	Salicin	9K6L-TAS2R16-Salicin-Gi2/β1/γ2
16.67	Single	9KVH	Cinobufotenine	9KVH-5-HT_1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
16.67	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
16.67	Single	9VJ5	Gepirone	9VJ5-5-HT_1A-Gepirone-Go/β1/γ2
16.67	Single	9VJE	Buspirone	9VJE-5-HT_1A-Buspirone-Go/β1/γ2
16.67	Single	9W49	U-50488H	9W49-κ-U-50488H-Gi1/β1/γ2
16.67	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
16.67	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
16.67	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
16.67	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
16.67	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
16.67	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
16.67	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
16.67	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.67	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.13	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
16.00	Single	4AMJ	Carvedilol	4AMJ-β₁-Carvedilol
16.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
16.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
16.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
16.00	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
16.00	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
15.79	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
15.79	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
15.79	Single	4LDO	Epinephrine	4LDO-β₂-Epinephrine
15.79	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
15.79	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
15.79	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
15.79	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
15.79	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
15.79	Single	6PS0	Carazolol	6PS0-β₂-Carazolol
15.79	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
15.79	Single	6TPG	EMPA	6TPG-OX₂-EMPA
15.79	Single	6VI4	JDTic	6VI4-κ-JDTic
15.79	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
15.79	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
15.79	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
15.79	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
15.79	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
15.79	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
15.79	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
15.79	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
15.79	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
15.79	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
15.79	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
15.79	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
15.79	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.79	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
15.79	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.79	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GE5	Constrained Epinephrine	8GE5-β₂-Constrained Epinephrine-Gs/β1/γ1
15.79	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
15.79	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
15.79	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
15.79	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
15.79	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
15.79	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
15.79	Single	8GUR	CP55940	8GUR-CB₂-CP55940-Gi1/β1/γ2
15.79	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
15.79	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
15.79	Single	8JEI	PubChem 11715556	8JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
15.79	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
15.79	Single	8JIM	Monomethyl fumarate	8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2
15.79	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.79	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
15.79	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
15.79	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
15.79	Single	8PM2	DMCHA	8PM2-TA7-DMCHA-Gs/β1/γ2
15.79	Single	8THK	A-61603	8THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	8U02	Dopamine	8U02-D₂-Dopamine-Go/β1/γ2
15.79	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
15.79	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
15.79	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
15.79	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.79	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
15.79	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
15.79	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
15.79	Single	8ZBW	Quin-C1	8ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
15.79	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
15.79	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
15.79	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
15.79	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	9BA0	MRI-1891	9BA0-CB₁-MRI-1891
15.79	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
15.79	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79	Single	9JH3	CMF-019	9JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
15.79	Single	9JKY	Acifran	9JKY-HCA₂-Acifran-Gi1/β1/γ2
15.79	Single	9KVI	Bufotenin	9KVI-5-HT_1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
15.79	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
15.79	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
15.79	Single	9ODL	Mitragynine Pseudoindoxyl	9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
15.79	Single	9PY2	Loperamide	9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
15.79	Single	9VJG	8-OH-DPAT	9VJG-5-HT_1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
15.79	Single	9VNF	Pindolol	9VNF-5-HT_1A-Pindolol-Go/β1/γ2
15.79	Single	9W6W	5-CT	9W6W-5-HT_5A-5-CT-Gi1/β1/γ2
15.79	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
15.79	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
15.79	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
15.79	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
15.79	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
15.79	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
15.79	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
15.79	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
15.79	Consensus	hca_on	Orthosteric Ligand	hca2_on
15.79	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.38	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
15.00	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
15.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
15.00	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
15.00	Single	3NYA	Alprenolol	3NYA-β₂-Alprenolol
15.00	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
15.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
15.00	Single	4GBR	Carazolol	4GBR-β₂-Carazolol
15.00	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
15.00	Single	4U16	N-methyl-Scopolamine	4U16-M₃-N-methyl-Scopolamine
15.00	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
15.00	Single	5DHG	C-35	5DHG-NOP-C-35
15.00	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
15.00	Single	5YC8	N-methyl-Scopolamine	5YC8-M₂-N-methyl-Scopolamine
15.00	Single	5ZK8	N-methyl-Scopolamine	5ZK8-M₂-N-methyl-Scopolamine
15.00	Single	5ZKC	N-methyl-Scopolamine	5ZKC-M₂-N-methyl-Scopolamine
15.00	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
15.00	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
15.00	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
15.00	Single	6PS1	Timolol	6PS1-β₂-Timolol
15.00	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
15.00	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
15.00	Single	7BTS	Epinephrine	7BTS-β₁-Epinephrine
15.00	Single	7BU6	Norepinephrine	7BU6-β₁-Norepinephrine
15.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
15.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
15.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
15.00	Single	7LJC	SKF81297	7LJC-D₁-SKF81297-Mevidalen-Gs/β1/γ2
15.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
15.00	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
15.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.00	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.00	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
15.00	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
15.00	Single	8GE2	Constrained Epinephrine	8GE2-β₂-Constrained Epinephrine-Gs/β1/γ1
15.00	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
15.00	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
15.00	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
15.00	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
15.00	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
15.00	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
15.00	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
15.00	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
15.00	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
15.00	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
15.00	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
15.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
15.00	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
15.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
15.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
15.00	Single	8JHN	Monomethyl fumarate	8JHN-HCA₂-Monomethyl fumarate-Go/β1/γ2
15.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
15.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
15.00	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
15.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
15.00	Single	8JXR	LSD	8JXR-D₁-LSD
15.00	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
15.00	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-Gi1/β1/γ1
15.00	Single	8T1W	CVN424	8T1W-GPR6-CVN424
15.00	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
15.00	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.00	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.00	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
15.00	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
15.00	Single	8Y71	A1D6F	8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
15.00	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
15.00	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
15.00	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
15.00	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
15.00	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-PtdIns4P-Gi1/β1/γ2
15.00	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.00	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
15.00	Single	9JEA	Atropine	9JEA-M₁-Atropine
15.00	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
15.00	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
15.00	Single	9PLN	PubChem 168259594	9PLN-α_2a-PubChem 168259594
15.00	Single	9PLO	PubChem 168259594	9PLO-α_2a-PubChem 168259594-Go/β1/γ2
15.00	Single	9PQD	PubChem 176491927	9PQD-α_2a-PubChem 176491927
15.00	Single	9VMY	TMU4142	9VMY-5-HT_1A-TMU4142-Go/β1/γ2
15.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
15.00	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
15.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
15.00	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
15.00	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
15.00	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
15.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
15.00	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
15.00	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
15.00	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
15.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
15.00	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
15.00	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
15.00	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
15.00	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.00	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
15.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
15.00	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
15.00	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.00	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
15.00	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
15.00	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
15.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
15.00	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
15.00	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.29	Single	2RH1	Carazolol	2RH1-β₂-Carazolol
14.29	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
14.29	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
14.29	Single	2YCW	Carazolol	2YCW-β₁-Carazolol
14.29	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
14.29	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
14.29	Single	5C1M	BU72	5C1M-μ-BU72
14.29	Single	5D6L	Carazolol	5D6L-β₂-Carazolol
14.29	Single	5JQH	Carazolol	5JQH-β₂-Carazolol
14.29	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
14.29	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
14.29	Single	5WQC	EMPA	5WQC-OX₂-EMPA
14.29	Single	5X7D	Carazolol	5X7D-β₂-Carazolol-PubChem 129318963
14.29	Single	6GPX	MK0812	6GPX-CCR2-MK0812
14.29	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
14.29	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
14.29	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
14.29	Single	6PS3	Carvedilol	6PS3-β₂-Carvedilol
14.29	Single	6PS6	Timolol	6PS6-β₂-Timolol
14.29	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
14.29	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
14.29	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
14.29	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
14.29	Single	7BVQ	Carazolol	7BVQ-β₁-Carazolol
14.29	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
14.29	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.29	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
14.29	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
14.29	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
14.29	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
14.29	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
14.29	Single	7WIG	L-054264	7WIG-SST2-L-054264-Gi1/β1/γ2
14.29	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
14.29	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
14.29	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
14.29	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
14.29	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
14.29	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
14.29	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
14.29	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
14.29	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
14.29	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
14.29	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
14.29	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
14.29	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
14.29	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.29	Single	8ZMF	PubChem 171920673	8ZMF-5-HT_2C-PubChem 171920673
14.29	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
14.29	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
14.29	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-PtdIns4P-Go/β1/γ2
14.29	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
14.29	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
14.29	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
14.29	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
14.29	Single	9JKS	PubChem 44250176	9JKS-HCA₃-PubChem 44250176-Gi1/β1/γ2
14.29	Single	9KT6	Acifran	9KT6-HCA₃-Acifran-Gi1/β1/γ2
14.29	Single	9KUV	CMPD644	9KUV-Apelin-CMPD644-Arrestin2
14.29	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
14.29	Single	9PXY	Naloxone	9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
14.29	Single	9VJF	Buspirone	9VJF-5-HT_1A-Buspirone-Gi3/β1/γ2
14.29	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.29	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.29	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
14.29	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
14.29	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
14.29	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
14.29	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
14.29	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
14.29	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
14.29	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
14.29	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
14.29	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.29	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
14.29	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
14.29	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.29	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-Carazolol 6PS3-β₂-Carvedilol 6PS5-β₂-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-PubChem 913103 6PRZ-β₂-Alprenolol
14.29	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
14.29	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
14.29	Consensus	blt_off	Orthosteric Ligand	blt1_off
14.29	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
14.29	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
14.29	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
14.29	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
14.29	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
14.29	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
14.29	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
14.29	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
14.29	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
13.79	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.79	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
13.79	Single	8XQE	Apelin-13	8XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
13.79	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.64	Single	2YDV	NECA	2YDV-A_2A-NECA
13.64	Single	4DJH	JDTic	4DJH-κ-JDTic
13.64	Single	4LDL	Hydroxybenzyl Isoproterenol	4LDL-β₂-Hydroxybenzyl Isoproterenol
13.64	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
13.64	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
13.64	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
13.64	Single	5D5A	Carazolol	5D5A-β₂-Carazolol
13.64	Single	5D5B	Carazolol	5D5B-β₂-Carazolol
13.64	Single	5G53	NECA	5G53-A_2A-NECA-Gs
13.64	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
13.64	Single	5XR8	AM12033	5XR8-CB₁-AM12033
13.64	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
13.64	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
13.64	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
13.64	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
13.64	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
13.64	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.64	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
13.64	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
13.64	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
13.64	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
13.64	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
13.64	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
13.64	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
13.64	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
13.64	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
13.64	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
13.64	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
13.64	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
13.64	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
13.64	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
13.64	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
13.64	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
13.64	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.64	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
13.64	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
13.64	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
13.64	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
13.64	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
13.64	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
13.64	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
13.64	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
13.64	Single	8WU1	MDMB-Fubinaca	8WU1-CB₁-MDMB-Fubinaca-Arrestin2
13.64	Single	8X0F	VU29	8X0F-mGlu5; mGlu5-Quisqualate-VU29
13.64	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Single	8XZI	CMF-019	8XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
13.64	Single	9AS9	RS130-180	9AS9-5-HT_2A-RS130-180
13.64	Single	9ASA	RS130-180	9ASA-5-HT_2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	9B65	MDMB-Fubinaca	9B65-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
13.64	Single	9BJK	Naloxone	9BJK-μ-Naloxone-PubChem 171642066
13.64	Single	9BS9	LSD	9BS9-D₂-LSD
13.64	Single	9BSB	LSD	9BSB-D₂-LSD-chim(NtGi1-Go)/β1/γ2
13.64	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.64	Single	9IK9	Lanreotide	9IK9-SST1-Lanreotide-Gi1/β1/γ2
13.64	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
13.64	Single	9PY3	Loperamide	9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
13.64	Single	9PY4	Loperamide	9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
13.64	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
13.64	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
13.64	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
13.64	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
13.64	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-PubChem 594590-Na 3ZPR-β₁-PubChem 598754-Na
13.64	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
13.64	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
13.64	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
13.64	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.64	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.64	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
13.64	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
13.64	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
13.64	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
13.64	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
13.64	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
13.64	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.64	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
13.64	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
13.64	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
13.64	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
13.33	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
13.33	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
13.33	Single	6NBI	LA-PTH Analog	6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
13.33	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.33	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.33	Single	9JKV	PubChem 2736690	9JKV-HCA₃-PubChem 2736690-Gi1/β1/γ2
13.04	Single	3D4S	Timolol	3D4S-β₂-Timolol
13.04	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
13.04	Single	4LDE	BI167107	4LDE-β₂-BI167107
13.04	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
13.04	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
13.04	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
13.04	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
13.04	Single	6DRY	Methylergometrine	6DRY-5-HT_2B-Methylergometrine
13.04	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
13.04	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
13.04	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.04	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
13.04	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
13.04	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
13.04	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
13.04	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
13.04	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
13.04	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
13.04	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
13.04	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1
13.04	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
13.04	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
13.04	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
13.04	Single	8JJ8	Arformoterol	8JJ8-β₂-Arformoterol
13.04	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
13.04	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
13.04	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
13.04	Single	9EK0	Iperoxo	9EK0-M₅-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
13.04	Single	9KVG	5-MeO-DMT	9KVG-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
13.04	Single	9M8P	Oleic monoethanolamide	9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
13.04	Single	9V6O	Nalfurafine	9V6O-κ-Nalfurafine-Gi1/β1/γ2
13.04	Single	9VJ6	F-15599	9VJ6-5-HT_1A-F-15599-Gi3/β1/γ2
13.04	Single	9WXM	GPR15L(CT)	9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
13.04	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
13.04	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
13.04	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
13.04	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
13.04	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
13.04	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
13.04	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
13.04	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
13.04	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
13.04	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
13.04	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
13.04	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
13.04	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
13.04	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.04	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
13.04	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
13.04	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
13.04	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
13.04	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
13.04	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
13.04	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
13.04	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
13.04	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
13.04	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
12.90	Single	7EIB	Kallidin-des-Arg10	7EIB-BK₁-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
12.90	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
12.82	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
12.50	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
12.50	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
12.50	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
12.50	Single	5X93	K-8794	5X93-ET_B-K-8794
12.50	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
12.50	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
12.50	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.50	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
12.50	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
12.50	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
12.50	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
12.50	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
12.50	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
12.50	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
12.50	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
12.50	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8E0G	BU72	8E0G-μ-BU72
12.50	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.50	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50	Single	8GAG	Z8526711350	8GAG-CB₁-Z8526711350-Gi1/β1/γ2
12.50	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
12.50	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
12.50	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
12.50	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8XGS	Kisspeptin-1	8XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
12.50	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9CHU	Norepinephrine	9CHU-β₂-Norepinephrine
12.50	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-PtdIns4P-Go/β1/γ2
12.50	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
12.50	Single	9EE9	Adenosine	9EE9-A_2A-Adenosine-Gs/β1/γ2
12.50	Single	9KT8	Acifran	9KT8-HCA₂-Acifran-Gi1/β1/γ2
12.50	Single	9M54	Neuropeptide-VF	9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
12.50	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
12.50	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
12.50	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
12.50	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
12.50	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
12.50	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
12.50	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
12.50	Consensus	endothelin_off	Orthosteric Ligand	etb_off
12.50	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
12.50	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
12.50	Consensus	gs_histamine	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
12.50	Consensus	h2_on	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
12.50	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.50	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
12.50	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
12.50	Consensus	sensory_on	Orthosteric Ligand	opsins_on
12.12	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
12.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
12.00	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
12.00	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.00	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
12.00	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
12.00	Single	7XN9	L-054522	7XN9-SST2-L-054522
12.00	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
12.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
12.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
12.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
12.00	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
12.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
12.00	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
12.00	Single	9M0R	Neuropeptide-VF	9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
12.00	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-PtdIns4P-Gz/β1/γ2
12.00	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
12.00	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.00	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.76	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
11.76	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
11.76	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
11.76	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
11.76	Single	6LPB	PACAP27	6LPB-PAC₁-PACAP27-Gs/β1/γ1
11.76	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.76	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
11.76	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
11.76	Single	8ITF	DMCHA	8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.76	Single	8IU2	All-trans-Retinal	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
11.76	Single	8JEF	PubChem 11367166	8JEF-HCA₃-PubChem 11367166-Gi1/β1/γ2
11.76	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
11.76	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/β1/γ2
11.76	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.76	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76	Single	9JG1	Adriforant	9JG1-H₄-Adriforant
11.76	Single	9KT9	3,5-DHBA	9KT9-HCA₁-3,5-DHBA-Gi1/β1/γ2
11.76	Single	9LL7	DOI	9LL7-5-HT_2A-DOI-Gi1/β1/γ2
11.76	Consensus	5ht2_on	Orthosteric Ligand	5ht2b_on
11.76	Consensus	5ht2b_on	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
11.76	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
11.76	Consensus	h2_on_gp	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
11.76	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
11.76	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
11.76	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
11.76	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
11.54	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
11.54	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
11.54	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
11.54	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
11.54	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
11.54	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
11.54	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
11.54	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
11.54	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.54	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
11.54	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
11.54	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
11.54	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
11.54	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.54	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
11.54	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
11.54	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.43	Single	6WPW	ZP3780	6WPW-Glucagon-ZP3780-Gs/β1/γ2
11.11	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
11.11	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
11.11	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
11.11	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
11.11	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
11.11	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
11.11	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
11.11	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
11.11	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
11.11	Single	6DO1	(Sar1,Ile8)-Angiotensin II	6DO1-AT₁-(Sar1,Ile8)-Angiotensin II
11.11	Single	6LI0	C17	6LI0-GPR52-C17
11.11	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7RKM	CX3CL1	7RKM-US28-CX3CL1-Gi1/β1/γ2
11.11	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
11.11	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
11.11	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
11.11	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
11.11	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
11.11	Single	7XP6	Strychnine	7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.11	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
11.11	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
11.11	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/β1/γ2
11.11	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
11.11	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
11.11	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
11.11	Single	8JZZ	C5a-des-Arg	8JZZ-C5a₁-C5a-des-Arg-Go/β1/γ2
11.11	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
11.11	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
11.11	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AS2	DMT	9AS2-5-HT_2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AS7	Psilocin	9AS7-5-HT_2A-Psilocin
11.11	Single	9IJE	Epinephrine	9IJE-β₃-Epinephrine-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9IK8	Pasireotide	9IK8-SST1-Pasireotide-Gi1/β1/γ2
11.11	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
11.11	Single	9KT7	MK6892	9KT7-HCA₂-MK6892-Gi1/β1/γ2
11.11	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
11.11	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
11.11	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
11.11	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
11.11	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
11.11	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
11.11	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
11.11	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
11.11	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
10.81	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
10.71	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
10.71	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
10.71	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
10.71	Single	6VN7	PACAP27	6VN7-VPAC₁-PACAP27-Gs/β1/γ2
10.71	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
10.71	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
10.71	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.71	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
10.71	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.71	Single	8XZG	Apelin-13	8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
10.71	Single	9B54	VIP36	9B54-CB₁-VIP36-Gi1/β1/γ2
10.71	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.71	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.71	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
10.71	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
10.53	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
10.53	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
10.53	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
10.53	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
10.53	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
10.53	Single	5WS3	EMPA	5WS3-OX₂-EMPA
10.53	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
10.53	Single	6OBA	Alprenolol	6OBA-β₂-Alprenolol-GTPL11074
10.53	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
10.53	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
10.53	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
10.53	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
10.53	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.53	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/β1/γ2
10.53	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
10.53	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
10.53	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
10.53	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
10.53	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
10.53	Single	8DWG	ML382	8DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
10.53	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
10.53	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
10.53	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
10.53	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
10.53	Single	8YUT	Amthamine	8YUT-H₂-Amthamine-Gs/β1/γ2
10.53	Single	9EBH	Adenosine	9EBH-A_3A-Adenosine-Gi1/β1/γ2
10.53	Single	9EEA	Adenosine	9EEA-A_2A-Adenosine-Gs/β1/γ2
10.53	Single	9KPE	Salicin	9KPE-TAS2R16-Salicin-Gi1/β1/γ2
10.53	Single	9LKD	PL45	9LKD-OR5V1-PL45
10.53	Single	9LL9	DOI	9LL9-5-HT_2A-DOI-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	9LLB	DOI-NBOMe	9LLB-5-HT_2A-DOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	9LRB	Histamine	9LRB-H₁-Histamine-Gs/β1/γ2
10.53	Single	9M88	Oleic monoethanolamide	9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
10.53	Single	9PEE	PF-07054894; OXM2	9PEE-CCR6-PF-07054894; OXM2
10.53	Single	9PXU	Naloxone	9PXU-μ-Naloxone-Na
10.53	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
10.53	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
10.53	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
10.53	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
10.53	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
10.53	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
10.53	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
10.53	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.53	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
10.53	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
10.53	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
10.34	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
10.34	Single	6M1I	PACAP27	6M1I-PAC₁-PACAP27-Gs/β1/γ2
10.34	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.34	Single	7F6G	(Sar1)-Angiotensin II	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
10.34	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.34	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
10.34	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
10.34	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
10.34	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
10.34	Single	8WST	MCH	8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34	Single	8X8L	Cortistatin-14	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.34	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.34	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
10.34	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
10.34	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34	Single	9BLC	Cagrilintide (non-acylated)	9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
10.34	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
10.34	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
10.34	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
10.34	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
10.26	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
10.00	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
10.00	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
10.00	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
10.00	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
10.00	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
10.00	Single	6IQL	L745870	6IQL-D₄-L745870
10.00	Single	6KUX	RS79948	6KUX-α_2a-RS79948
10.00	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
10.00	Single	6PS5	Propranolol	6PS5-β₂-Propranolol
10.00	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
10.00	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
10.00	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
10.00	Single	6TPK	Retosiban	6TPK-OT-Retosiban
10.00	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
10.00	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
10.00	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
10.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
10.00	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
10.00	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
10.00	Single	7F61	PF-03654746	7F61-H₃-PF-03654746
10.00	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
10.00	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
10.00	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.00	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
10.00	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
10.00	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
10.00	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
10.00	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
10.00	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
10.00	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
10.00	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
10.00	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
10.00	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
10.00	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
10.00	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
10.00	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
10.00	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
10.00	Single	8K9K	DAMGO	8K9K-μ-DAMGO-Gi3/β1/γ1
10.00	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.00	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
10.00	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
10.00	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
10.00	Single	8Y01	All-trans-Retinal	8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
10.00	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
10.00	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
10.00	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
10.00	Single	9ARX	Serotonin	9ARX-5-HT_2A-Serotonin
10.00	Single	9AS8	Psilocin	9AS8-5-HT_2A-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
10.00	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
10.00	Single	9KPD	Salicin	9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
10.00	Single	9L84	Epinephrine	9L84-β₁-Epinephrine-Atazanavir-Gs/β1/γ2
10.00	Single	9L8L	BI167107	9L8L-β₂-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
10.00	Single	9LKB	PL45	9LKB-OR5V1-PL45-chim(NtGi1-Gs)/β1
10.00	Single	9LL8	Psilocin	9LL8-5-HT_2A-Psilocin-Gi1/β1/γ2
10.00	Single	9PXV	Naloxone	9PXV-μ-Naloxone-Gi1/β1/γ2
10.00	Single	9PXX	Naloxone	9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
10.00	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
10.00	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
10.00	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
10.00	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
10.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
10.00	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
10.00	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.00	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
10.00	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
10.00	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
10.00	Consensus	pac_on	Orthosteric Ligand	pac1_on
10.00	Consensus	sensory_off	Orthosteric Ligand	opsins_off
10.00	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
10.00	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
9.68	Single	6NBF	LA-PTH Analog	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
9.68	Single	6P9Y	PACAP27	6P9Y-PAC₁-PACAP27-Gs/β1/γ2
9.68	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.68	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
9.68	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
9.68	Single	7VAB	Tirzepatide (non-acylated)	7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
9.68	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
9.68	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.68	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.68	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
9.68	Single	9P92	VIP	9P92-PAC₁-VIP-Gs/β1/γ2
9.68	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
9.68	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
9.68	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
9.68	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
9.68	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
9.68	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
9.52	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
9.52	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
9.52	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
9.52	Single	3ZPQ	PubChem 594590	3ZPQ-β₁-PubChem 594590-Na
9.52	Single	3ZPR	PubChem 598754	3ZPR-β₁-PubChem 598754-Na
9.52	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
9.52	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
9.52	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
9.52	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
9.52	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
9.52	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
9.52	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
9.52	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
9.52	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
9.52	Single	5ZKP	SR27417	5ZKP-PAF-SR27417
9.52	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
9.52	Single	6GPS	MK0812	6GPS-CCR2-MK0812
9.52	Single	6KPF	AM12033	6KPF-CB₂-AM12033-Gi1/β1/γ2
9.52	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
9.52	Single	6PRZ	Alprenolol	6PRZ-β₂-Alprenolol
9.52	Single	6PS2	Alprenolol	6PS2-β₂-Alprenolol
9.52	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52	Single	7BU7	BI167107	7BU7-β₁-BI167107
9.52	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
9.52	Single	7JOZ	PubChem 75202022	7JOZ-D₁-PubChem 75202022-Gs/β1/γ2
9.52	Single	7M3J	NPS-2143; PO4	7M3J-CaS; CaS-NPS-2143; PO4
9.52	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
9.52	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
9.52	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
9.52	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.52	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
9.52	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
9.52	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
9.52	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
9.52	Single	7XJH	Isoprenaline	7XJH-β₃-Isoprenaline-Gs/β1/γ2
9.52	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
9.52	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
9.52	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
9.52	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
9.52	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.52	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
9.52	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
9.52	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
9.52	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
9.52	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.52	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
9.52	Single	8ZQE	GPR15L(CT)	8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
9.52	Single	9AS1	DMT	9AS1-5-HT_2A-DMT
9.52	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
9.52	Single	9CHX	Carazolol	9CHX-β₂-Carazolol
9.52	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
9.52	Single	9LLA	Ariadne	9LLA-5-HT_2A-Ariadne-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	9PXW	Naloxone	9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
9.52	Single	9UAZ	Atropine	9UAZ-M₁-Atropine
9.52	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
9.52	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.52	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
9.52	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
9.52	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
9.52	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
9.52	Consensus	a3_on	Orthosteric Ligand	a3a_on
9.52	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	blt_on	Orthosteric Ligand	blt1_on
9.52	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
9.52	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
9.52	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
9.52	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
9.52	Consensus	histamine_off	Orthosteric Ligand	h1_off
9.52	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
9.52	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
9.52	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.52	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
9.38	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
9.38	Single	6P9X	Corticoliberin-1	6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
9.38	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
9.38	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
9.38	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
9.38	Single	7S1M	Exendin-4-D-Ala	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
9.38	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
9.38	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
9.38	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
9.38	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
9.38	Single	8FU6	ZP3780	8FU6-Glucagon-ZP3780-Gs/β1/γ2
9.38	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
9.38	Single	8ZH8	QRFP26	8ZH8-QRFP-QRFP26-Gq/β1/γ1
9.38	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
9.38	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
9.38	Single	9P94	PACAP27	9P94-PAC₁-PACAP27-Gs/β1/γ2
9.38	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.38	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
9.38	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
9.38	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
9.30	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
9.09	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
9.09	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
9.09	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
9.09	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
9.09	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
9.09	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
9.09	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
9.09	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
9.09	Single	6KPC	AM12033	6KPC-CB₂-AM12033
9.09	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
9.09	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
9.09	Single	6NBH	LA-PTH Analog	6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
9.09	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.09	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.09	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.09	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
9.09	Single	7C4S	S1P	7C4S-S1P₃-S1P
9.09	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
9.09	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
9.09	Single	7EPF	NAM597	7EPF-mGlu₂-NAM597
9.09	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
9.09	Single	7M3J	NPS-2143; PO4	7M3J-CaS; CaS-NPS-2143; PO4
9.09	Single	7SIN	NPS-2143	7SIN-CaS; CaS-NPS-2143
9.09	Single	7SIN	NPS-2143	7SIN-CaS; CaS-NPS-2143
9.09	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
9.09	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
9.09	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
9.09	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
9.09	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
9.09	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.09	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
9.09	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
9.09	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
9.09	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
9.09	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
9.09	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
9.09	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
9.09	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
9.09	Single	8ZRK	GSK1292263	8ZRK-GPR119-GSK1292263-Gs/β1/γ2
9.09	Single	9ARY	Serotonin	9ARY-5-HT_2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
9.09	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
9.09	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
9.09	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
9.09	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
9.09	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
9.09	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	9KPF	Salicin	9KPF-TAS2R16-Salicin-Gi1/β1/γ2
9.09	Single	9KUT	JR14a	9KUT-C3a_B-JR14a-Go/β1/γ2
9.09	Single	9L74	S1P d16:1	9L74-S1P₃-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	9M8P	Oleic monoethanolamide	9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
9.09	Single	9P93	VIP	9P93-PAC₁-VIP-Gs/β1/γ2
9.09	Single	9U81	Tolvaptan	9U81-V₂-Tolvaptan
9.09	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
9.09	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
9.09	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
9.09	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
9.09	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.09	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.09	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
9.09	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
8.82	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
8.82	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
8.82	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
8.82	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
8.82	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
8.82	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
8.70	Single	3P0G	BI167107	3P0G-β₂-BI167107
8.70	Single	3PDS	FAUC50	3PDS-β₂-FAUC50
8.70	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
8.70	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
8.70	Single	5V56	TC114	5V56-SMO-TC114
8.70	Single	5V57	TC114	5V57-SMO-TC114
8.70	Single	5XRA	AM11542	5XRA-CB₁-AM11542
8.70	Single	6E59	L-760735	6E59-NK₁-L-760735
8.70	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
8.70	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
8.70	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
8.70	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
8.70	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
8.70	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
8.70	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
8.70	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
8.70	Single	7EW4	CYM-5541	7EW4-S1P₃-CYM-5541-Gi1/β1/γ2
8.70	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.70	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
8.70	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
8.70	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
8.70	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
8.70	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
8.70	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
8.70	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
8.70	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
8.70	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
8.70	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
8.70	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.70	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.70	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
8.70	Single	8UGW	CGS21680	8UGW-A_2A-CGS21680
8.70	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
8.70	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
8.70	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
8.70	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
8.70	Single	9EGO	Z8526711350	9EGO-CB₁-Z8526711350-Gi1/β1/γ2
8.70	Single	9I54	PubChem 176452091	9I54-D₁-PubChem 176452091-Gs/β1/γ2
8.70	Single	9KVP	SB290157	9KVP-C3a_B-SB290157-Go/β1/γ2
8.70	Single	9UCP	Iperoxo	9UCP-M₁-Iperoxo-G11(CT)
8.70	Single	9WST	DAMGO	9WST-μ-DAMGO-chim(NtGi1-Gz)/β1/γ2
8.70	Consensus	a2_on	Orthosteric Ligand	a2b_on
8.70	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
8.70	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
8.70	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
8.70	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
8.70	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
8.70	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
8.70	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
8.70	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
8.70	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
8.70	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
8.70	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
8.70	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
8.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.57	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.57	Single	8FLU	LA-PTH Analog	8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
8.33	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
8.33	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
8.33	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
8.33	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
8.33	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
8.33	Single	7EO4	Siponimod	7EO4-S1P₁-Siponimod-Gi1/β1/γ2
8.33	Single	7EPE	NAM563	7EPE-mGlu₂-NAM563
8.33	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
8.33	Single	7EW2	FTY720-P	7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
8.33	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
8.33	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
8.33	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
8.33	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
8.33	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
8.33	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
8.33	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
8.33	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
8.33	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
8.33	Single	8ID9	Icosapent	8ID9-FFA4-Icosapent-Gi1/β1/γ2
8.33	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
8.33	Single	8JD3	JNJ-40411813	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
8.33	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.33	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
8.33	Single	8JJP	Chemerin-9	8JJP-CML2-Chemerin-9-Gi1/β1/γ2
8.33	Single	8T3Q	Doconexent	8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
8.33	Single	8W8S	AA-14	8W8S-GPR101-AA-14
8.33	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
8.33	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Single	9M4Q	Doxazosin	9M4Q-Alpha1A-Doxazosin
8.33	Single	9VIF	Neuropeptide-VF	9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
8.33	Single	9W32	SSTR5 antagonist 1	9W32-SST5-SSTR5 antagonist 1
8.33	Single	9WSV	DAMGO	9WSV-μ-DAMGO-Arrestin2
8.33	Single	9WSW	Endomorphin	9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
8.33	Single	9YDQ	DADLE	9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
8.33	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
8.33	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
8.33	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
8.33	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
8.33	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
8.33	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
8.33	Consensus	orexin_on	Orthosteric Ligand	ox2_on
8.33	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
8.33	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.33	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.33	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
8.11	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.11	Single	7Y36	PTH	7Y36-PTH1-PTH-Gs/β1/γ2
8.11	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
8.11	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.11	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
8.11	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.11	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
8.00	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
8.00	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
8.00	Single	6DDF	DAMGO	6DDF-μ-DAMGO-Gi1/β1/γ2
8.00	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
8.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
8.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
8.00	Single	7EZC	UK-432097	7EZC-A_2A-UK-432097
8.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
8.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
8.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
8.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
8.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
8.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
8.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
8.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
8.00	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
8.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
8.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
8.00	Single	8WRZ	AM841	8WRZ-CB₁-AM841-Arrestin2
8.00	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
8.00	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
8.00	Single	9KUG	EP67	9KUG-C5a₁-EP67-Go/β1/γ2
8.00	Single	9L79	AR231453	9L79-GPR119-AR231453-chim(NtGi1-Gs)/β1/γ2
8.00	Single	9UYM	Chemerin-9	9UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
8.00	Single	9WP9	S1P	9WP9-S1P₃-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00	Single	9YDP	DADLE	9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
8.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
8.00	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
8.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
8.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
8.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
8.00	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
8.00	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
8.00	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
8.00	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
7.89	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.69	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
7.69	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
7.69	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.69	Single	7RKF	CX3CL1	7RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
7.69	Single	7RKN	CX3CL1	7RKN-US28-CX3CL1-Gi1/β1/γ2
7.69	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
7.69	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69	Single	8XZF	WN561	8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
7.69	Single	8Y72	Peptide	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
7.69	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
7.69	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
7.69	Single	9JF4	PD168368	9JF4-BB₁-PD168368
7.69	Single	9UMJ	EP54	9UMJ-C3a_B-EP54-Go/β1/γ2
7.69	Single	9WSX	Endomorphin	9WSX-μ-Endomorphin-Arrestin2
7.69	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
7.69	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
7.69	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.69	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.69	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
7.69	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
7.50	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
7.41	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
7.41	Single	4XT1	CX3CL1	4XT1-US28-CX3CL1
7.41	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
7.41	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.41	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
7.41	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7.41	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
7.41	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
7.41	Single	8IEB	PubChem 134746894	8IEB-GPR156; GPR156-PubChem 134746894
7.41	Single	8IEI	PubChem 134746894	8IEI-GPR156; GPR156-PubChem 134746894
7.41	Single	8IEI	PubChem 134746894	8IEI-GPR156; GPR156-PubChem 134746894
7.41	Single	8IEP	PubChem 134746894	8IEP-GPR156; GPR156-PubChem 134746894
7.41	Single	8IEP	PubChem 134746894	8IEP-GPR156; GPR156-PubChem 134746894
7.41	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.41	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
7.41	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
7.41	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
7.41	Single	9L3Y	Chemerin	9L3Y-CML2-Chemerin-Gi1/β1/γ2
7.41	Single	9UYJ	Chemerin-9	9UYJ-CML2-Chemerin-9-Arrestin2
7.41	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
7.41	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.41	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.41	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
7.41	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
7.41	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
7.14	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
7.14	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.14	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
7.14	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.14	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
7.14	Single	7PIV	Afamelanotide	7PIV-MC₄-Afamelanotide-Gs/β1/γ2
7.14	Single	7VBI	Tirzepatide (non-acylated)	7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
7.14	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
7.14	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.14	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
7.14	Single	8IEB	PubChem 134746894	8IEB-GPR156; GPR156-PubChem 134746894
7.14	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8WSS	MCH	8WSS-MCH1-MCH-Gi1/β1/γ1
7.14	Single	8Z7J	JN241-9	8Z7J-Apelin-JN241-9-Gi1/β1/γ2
7.14	Single	9JFK	(Pen5)-Urotensin II	9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
7.14	Single	9L60	Dynorphin	9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
7.14	Single	9ME1	CXCL12	9ME1-CXCR4-CXCL12
7.14	Single	9UMX	EP54	9UMX-C5a₁-EP54-Go/β1/γ2
7.14	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
7.14	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
7.14	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
7.14	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.14	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
7.14	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
7.14	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
6.90	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
6.90	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
6.90	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
6.90	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
6.90	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.90	Single	8XZH	MM07	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
6.90	Single	8YFO	Ac-LA-PTH Analog	8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
6.90	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.90	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
6.90	Single	9LXR	LA-PTH Analog	9LXR-PTH1-LA-PTH Analog-Arrestin2
6.90	Single	9M1O	Neuropeptide-FF	9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
6.90	Single	9MEU	CXCL12	9MEU-CXCR4-CXCL12
6.90	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90	Single	9UYI	Chemerin-9	9UYI-CML2-Chemerin-9-Arrestin2
6.90	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
6.90	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
6.90	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
6.90	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
6.90	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
6.90	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
6.90	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
6.90	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
6.67	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
6.67	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
6.67	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
6.67	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8IED	PubChem 134746894	8IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
6.67	Single	8IED	PubChem 134746894	8IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
6.67	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
6.67	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
6.67	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
6.67	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
6.67	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
6.67	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
6.67	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.67	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
6.67	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
6.67	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
6.67	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
6.67	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
6.45	Single	5YQZ	NNC1702	5YQZ-Glucagon-NNC1702
6.45	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
6.45	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
6.45	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
6.45	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.45	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
6.45	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.45	Single	8ZRT	Endothelin-1	8ZRT-ET_B-Endothelin-1
6.45	Single	9E2A	GLP-1	9E2A-GLP-1-GLP-1-Gs/β1/γ2
6.45	Single	9JFY	Neuropeptide-SF	9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
6.45	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
6.45	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
6.45	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
6.45	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
6.25	Single	4XT3	CX3CL1	4XT3-US28-CX3CL1
6.25	Single	6FJ3	PTH	6FJ3-PTH1-PTH
6.25	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.25	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
6.25	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
6.25	Single	7XKD	Dehydroepiandrosterone	7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
6.25	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
6.25	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
6.25	Single	9BLW	Cagrilintide (non-acylated)	9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
6.25	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
6.25	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
6.25	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
6.25	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.25	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
6.25	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
6.25	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
6.25	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
6.25	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
6.25	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
6.06	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.06	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
6.06	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
6.06	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
6.06	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.06	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
6.06	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.06	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
6.06	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
6.06	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
6.06	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
6.06	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
6.06	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
6.06	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
6.06	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
6.06	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
6.06	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
6.06	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
5.88	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
5.88	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
5.88	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
5.88	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.88	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
5.88	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
5.88	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
5.88	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
5.88	Single	8KGG	Lysophosphatidylserine (WJS)	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
5.88	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	8Y02	All-trans-Retinal	8Y02-OPN1SW-All-trans-Retinal-Gi1/β1/γ2
5.88	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
5.88	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.88	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
5.88	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
5.88	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
5.88	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
5.71	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.71	Single	8ZJE	TAK448	8ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
5.71	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
5.71	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
5.71	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
5.71	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.71	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.71	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
5.71	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
5.56	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.56	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
5.56	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.56	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.56	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
5.56	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.56	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9IJR	C17	9IJR-GPR52-C17-Arrestin2
5.56	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
5.56	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
5.56	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
5.41	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
5.41	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
5.26	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
5.26	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
5.26	Single	6HLL	CP99994	6HLL-NK₁-CP99994
5.26	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.26	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
5.26	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
5.26	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
5.26	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
5.26	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
5.26	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
5.26	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
5.26	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26	Single	9EPR	All-trans-Retinal	9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
5.26	Single	9JLC	AVE 0991	9JLC-MAS1-AVE 0991-Gi1/β1/γ2
5.26	Single	9KUW	CMPD644	9KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
5.26	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
5.26	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
5.26	Single	9M88	Oleic monoethanolamide	9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
5.26	Single	9YDA	All-trans-Retinal	9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
5.26	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
5.13	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.13	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.00	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
5.00	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.00	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.00	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
5.00	Single	4XNV	BPTU	4XNV-P2Y₁-BPTU
5.00	Single	6DS0	LY266097	6DS0-5-HT_2B-LY266097
5.00	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.00	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.00	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
5.00	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet	7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet	7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.00	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.00	Single	7T6S	TC-FPR 43	7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2
5.00	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
5.00	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
5.00	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
5.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
5.00	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
5.00	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
5.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
5.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.00	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
5.00	Single	9KO2	CCL19	9KO2-CCR7-CCL19-Gi1/β1
5.00	Single	9KO6	CCL19	9KO6-CCR7-CCL19
5.00	Single	9L60	MPAM-15	9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
5.00	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
4.88	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
4.76	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
4.76	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
4.76	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
4.76	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
4.76	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.76	Single	8JD6	VU0364770	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.76	Single	8K9L	DAMGO	8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
4.76	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
4.76	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
4.76	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
4.76	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
4.76	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
4.76	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
4.76	Single	9KUW	CMPD644	9KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
4.76	Single	9KXS	EP67	9KXS-C5a₁-EP67-Go/β1/γ2
4.76	Single	9M2F	Neuropeptide-FF	9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
4.76	Single	9W33	S5A1	9W33-SST5-S5A1
4.76	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.76	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
4.55	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
4.55	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
4.55	Single	5UEN	DU172	5UEN-A₁-DU172
4.55	Single	6D27	CAY10471	6D27-DP₂-CAY10471
4.55	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
4.55	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
4.55	Single	7NA8	Ibutamoren	7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
4.55	Single	7VGZ	Ramelteon	7VGZ-MT₁-Ramelteon-Gi1/β1/γ2
4.55	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
4.55	Single	7VIF	FTY720-P	7VIF-S1P₁-FTY720-P-Gi1/β1/γ2
4.55	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
4.55	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
4.55	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
4.55	Single	8EFQ	DAMGO	8EFQ-μ-DAMGO-Gi1/β1/γ2
4.55	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
4.55	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
4.55	Single	8Y73	MPAM-15	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.55	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
4.55	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9YDQ	MIPS3614	9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.55	Single	9YDR	MIPS3983	9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.55	Consensus	cck_off	Orthosteric Ligand	ccka_off
4.55	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
4.35	Single	5N2R	PSB36	5N2R-A_2A-PSB36-Na
4.35	Single	5N2S	PSB36	5N2S-A₁-PSB36
4.35	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
4.35	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
4.35	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
4.35	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
4.35	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35	Single	7VFX	fMIFL	7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
4.35	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
4.35	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
4.35	Single	7W41	PD176252	7W41-BB₂-PD176252
4.35	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
4.35	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
4.35	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.35	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
4.35	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9EHS	LUF7602	9EHS-A_3A-LUF7602
4.35	Single	9IYB	PGD2	9IYB-DP₂-PGD2-A1D5Q-Gi1/β1/γ2
4.35	Single	9KO4	CCL21	9KO4-CCR7-CCL21-Gi1/β1/γ2
4.35	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
4.35	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
4.35	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
4.35	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
4.35	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
4.35	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
4.35	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
4.35	Consensus	dp_off	Orthosteric Ligand	dp2_off
4.35	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
4.35	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
4.35	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
4.35	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.17	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
4.17	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
4.17	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.17	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.17	Single	6DDE	DAMGO	6DDE-μ-DAMGO-Gi1/β1/γ2
4.17	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
4.17	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
4.17	Single	7M8W	15r-Methyl-PGD2	7M8W-DP₂-15r-Methyl-PGD2-Na
4.17	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
4.17	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.17	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.17	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
4.17	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
4.17	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.17	Single	7XOW	Sulfated Gastrin-(10-17)	7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
4.17	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.17	Single	8HPT	C5a (C-terminal peptide)	8HPT-C5a₁-C5a (C-terminal peptide)-Go/β1/γ2
4.17	Single	8I2G	PubChem 67530240	8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.17	Single	8I9L	C3a	8I9L-C3a_B-C3a-Go/β1/γ2
4.17	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
4.17	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.17	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.17	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.17	Single	8ZWF	JR14a	8ZWF-C3a_B-JR14a
4.17	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.17	Single	9JMC	DS-3801b	9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
4.17	Single	9L16	CCL21	9L16-CCR7-CCL21
4.17	Single	9UY3	Anamorelin	9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.17	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
4.17	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
4.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.00	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
4.00	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
4.00	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
4.00	Single	6OS0	Angiotensin II	6OS0-AT₁-Angiotensin II
4.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
4.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.00	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
4.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8JWY	2-118	8JWY-A_2A-2-118
4.00	Single	8JWZ	Etrumadenant	8JWZ-A_2A-Etrumadenant-Na
4.00	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
4.00	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.00	Single	9KZK	C3a (fragment)	9KZK-C3a_B-C3a (fragment)-Go/β1/γ2
4.00	Single	9L3W	Chemerin	9L3W-CML1-Chemerin-Gi1/β1/γ2
4.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.00	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
4.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
4.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
4.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
3.85	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
3.85	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
3.85	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
3.85	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
3.85	Single	7Y65	C5a (C-terminal peptide)	7Y65-C5a₁-C5a (C-terminal peptide)-Gi1/β1/γ2
3.85	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
3.85	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
3.85	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.85	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
3.85	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	9IZF	LPA	9IZF-LPA₁-LPA-Gi1/β1/γ2
3.85	Single	9KV8	TLQP21	9KV8-C3a_B-TLQP21-Go/β1/γ2
3.85	Single	9UYH	Chemerin-9	9UYH-CML2-Chemerin-9-Arrestin2
3.85	Single	9VI9	RFRP-3	9VI9-NPFF1-RFRP-3-Gi1/β1/γ2
3.85	Single	9YDR	DADLE	9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
3.85	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
3.85	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	5VBL	AMG3054	5VBL-Apelin-AMG3054
3.70	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
3.70	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
3.70	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
3.70	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
3.70	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs/β1/γ2
3.70	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.70	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
3.70	Single	9KX6	C5a-des-Arg	9KX6-C5a₁-C5a-des-Arg-Go/β1/γ2
3.70	Single	9KZ2	EP67	9KZ2-C3a_B-EP67-Go/β1/γ2
3.70	Single	9KZ8	EP67	9KZ8-C3a_B-EP67-Go/β1/γ2
3.70	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.70	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.70	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
3.70	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.70	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
3.70	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
3.57	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.57	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
3.57	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
3.57	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
3.57	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.57	Single	8IZB	Lysophosphatidylserine (UBL)	8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
3.57	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.57	Single	8WKY	PG-934	8WKY-MC₄-PG-934
3.57	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
3.57	Single	8ZJD	Kisspeptin-1	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.57	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
3.57	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
3.57	Single	9KWG	C5a	9KWG-C5a₁-C5a-Go/β1/γ2
3.57	Single	9UMR	C5a-pep	9UMR-C5a₁-C5a-pep-Go/β1/γ2
3.57	Single	9UYL	Chemerin-9	9UYL-CML2-Chemerin-9-Arrestin2
3.57	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
3.57	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.57	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
3.57	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
3.57	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
3.57	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
3.57	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.57	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.45	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
3.45	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
3.45	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
3.45	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
3.45	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
3.45	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.45	Single	8K6O	Neuropeptide-Y	8K6O-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.45	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.45	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
3.45	Single	9E82	CXCL12 (fragment)	9E82-ACKR3-CXCL12 (fragment)-Arrestin2
3.45	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
3.45	Single	9KV6	TLQP21	9KV6-C3a_B-TLQP21-Go/β1/γ2
3.45	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
3.45	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.45	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
3.45	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
3.45	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
3.45	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
3.45	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.33	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
3.33	Single	6MEO	Gp160; CD4	6MEO-CCR5-Gp160; CD4
3.33	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
3.33	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
3.33	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
3.33	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.33	Single	8K6N	Neuropeptide-Y	8K6N-Y₂-Neuropeptide-Y-Gi2/β1/γ1
3.33	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
3.33	Single	9B5Y	LA-PTH Analog	9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
3.33	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
3.33	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
3.33	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
3.33	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.33	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.33	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
3.23	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.23	Single	6MET	Gp160; CD4	6MET-CCR5-Gp160; CD4
3.23	Single	6NIY	Calcitonin-1	6NIY-CT-Calcitonin-1-Gs/β1/γ2
3.23	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
3.23	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
3.23	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.23	Single	8XZJ	WN353	8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
3.23	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
3.23	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.23	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.23	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
3.23	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
3.23	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
3.23	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
3.12	Single	7F9Y	Ghrelin	7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	7P02	Substance-P	7P02-NK₁-Substance-P-chim(NtGi1-Gs)/β1/γ2
3.12	Single	7TYH	Calcitonin	7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
3.12	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.12	Single	7XV3	Lysophosphatidylserine (WJS)	7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
3.12	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.12	Single	7Y64	C5a	7Y64-C5a₁-C5a-Gi1/β1/γ2
3.12	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12	Single	8HK5	C5a	8HK5-C5a₁-C5a-Gi1/β1/γ2
3.12	Single	8IA2	C5a	8IA2-C5a₁-C5a-Go/β1/γ2
3.12	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.12	Single	8YG4	LA-PTH Analog	8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.12	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
3.12	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
3.12	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
3.12	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.03	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
3.03	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
3.03	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.03	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.03	Single	9BLB	Cagrilintide (non-acylated)	9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
3.03	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
3.03	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
3.03	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
3.03	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
2.94	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
2.86	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
2.86	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.86	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
2.86	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
2.86	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.86	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
2.86	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.78	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.78	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.78	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.78	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
2.78	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.78	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.70	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.70	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
2.70	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.63	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.56	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2

PDB Summary
PDB	9EE5
Class	A
SubFamily	Lipid
Type	Prostanoid
SubType	DP1
Species	Homo Sapiens
Ligand	ONO-2550289
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.89
Date	2025-09-03
D.O.I.	doi.org/10.1038/s41467-025-64002-z

Net Summary
I_min	2.92
Number of Linked Nodes	277
Number of Links	309
Number of Hubs	28
Number of Links mediated by Hubs	111
Number of Communities	10
Number of Nodes involved in Communities	60
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	53863
Length Of Smallest Path	3
Average Path Length	15.168
Length of Longest Path	38
Minimum Path Strength	1.215
Average Path Strength	6.29459
Maximum Path Strength	19.755
Minimum Path Correlation	0.7
Average Path Correlation	0.935671
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.9639
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.1773
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • sleep • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • establishment of organelle localization • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • cellular process • developmental process • multicellular organism development • sex determination • male sex determination • reproductive process • anatomical structure development • developmental process involved in reproduction • defense response • response to stress • inflammatory response • cellular response to stimulus • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • response to chemical • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • regulation of biological process • regulation of cellular process • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • carbohydrate derivative metabolic process • primary metabolic process • nucleoside metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • adenosine metabolic process • nucleobase-containing small molecule metabolic process • metabolic process • small molecule metabolic process • purine nucleoside metabolic process • ribonucleoside metabolic process • purine ribonucleoside metabolic process • cellular anatomical structure • membrane • cell periphery • plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13258
Sequence	>9EE5_Chain_R S P F Y R C Q N T T S V E K G N S A V M G G V L F S T G L L G N L L A L G L L A R S G L G S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N R S L R V L A P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E W L S L G H P F F Y R R H I T L R L G A L V A P V V S A F S L A F C A L P F M G F G K F V Q Y C P G T W C F I Q M V H E E G S L S V L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q L E E L D L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K D V K E K N R T S E E A E D L R A L R F L S V I S I V P W I F I I F R S P V F R I F F H K I F R A N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9E9S	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ1	2.68	2025-09-03	To be published
	9E9S (No Gprot)	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-		2.68	2025-09-03	To be published
	9EI5	A	Lipid	Prostanoid	DP₁	Homo sapiens	-	-	-	2.84	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9EKH	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-3030297	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9UWD	A	Lipid	Prostaglandin	DP₁	Homo sapiens	-	-	-	-	2025-04-09	doi.org/10.1073/pnas.2501902122
	8ZVZ	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZVZ (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	9AU0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.45	2025-08-27	To be published
	9AU0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.45	2025-08-27	To be published

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