psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?1	R:R:P4	5.89	No	No	0	0	6
2	H:H:?1	R:R:Q9	17.91	No	No	1	0	2
3	H:H:?1	R:R:N10	27.11	No	No	1	0	6
4	L:L:?1	R:R:L26	3.64	Yes	No	0	0	8
5	L:L:?1	R:R:K76	12.06	Yes	Yes	1	0	8
6	L:L:?1	R:R:S80	10.86	Yes	No	0	0	8
7	L:L:?1	R:R:V83	7.84	Yes	No	0	0	9
8	L:L:?1	R:R:Y87	6.94	Yes	No	1	0	8
9	L:L:?1	R:R:M112	7.44	Yes	Yes	1	0	8
10	L:L:?1	R:R:T181	4.85	Yes	Yes	1	0	9
11	L:L:?1	R:R:W182	8.99	Yes	Yes	1	0	9
12	L:L:?1	R:R:L306	4.55	Yes	No	1	0	7
13	L:L:?1	R:R:R310	5.59	Yes	No	1	0	9
14	L:L:?1	R:R:L312	4.55	Yes	No	0	0	8
15	L:L:?1	R:R:S313	13.83	Yes	No	0	0	9
16	R:R:R298	R:R:S3	5.27	No	No	0	1	6
17	R:R:F5	R:R:Y6	11.35	Yes	Yes	1	4	6
18	R:R:F5	R:R:V188	13.11	Yes	Yes	1	4	3
19	R:R:F5	R:R:V293	3.93	Yes	Yes	1	4	1
20	R:R:E301	R:R:F5	4.66	No	Yes	0	3	4
21	R:R:V175	R:R:Y6	11.36	Yes	Yes	1	4	6
22	R:R:Y177	R:R:Y6	9.93	Yes	Yes	1	9	6
23	R:R:Q186	R:R:Y6	6.76	Yes	Yes	1	5	6
24	R:R:V188	R:R:Y6	5.05	Yes	Yes	1	3	6
25	R:R:C8	R:R:R7	4.18	No	Yes	3	9	4
26	R:R:E15	R:R:R7	10.47	Yes	Yes	3	3	4
27	R:R:C178	R:R:R7	6.96	No	Yes	3	4	4
28	R:R:R298	R:R:R7	5.33	No	Yes	3	1	4
29	R:R:E302	R:R:R7	13.96	No	Yes	3	3	4
30	R:R:C8	R:R:E15	4.56	No	Yes	3	9	3
31	R:R:C178	R:R:C8	7.28	No	No	3	4	9
32	R:R:N10	R:R:Q9	9.24	No	No	1	6	2
33	R:R:Q9	R:R:V175	5.73	No	Yes	1	2	4
34	R:R:N10	R:R:R94	4.82	No	No	0	6	2
35	R:R:E15	R:R:T11	4.23	Yes	No	0	3	4
36	R:R:S92	R:R:T11	3.2	No	No	0	5	4
37	R:R:T12	R:R:V95	3.17	No	No	0	5	2
38	R:R:N90	R:R:S13	2.98	No	No	0	5	1
39	R:R:N90	R:R:V14	5.91	No	No	0	5	4
40	R:R:E15	R:R:P179	3.14	Yes	No	0	3	8
41	R:R:N18	R:R:P179	11.4	No	No	0	3	8
42	R:R:S19	R:R:V21	4.85	No	No	0	6	3
43	R:R:A20	R:R:Y87	6.67	No	No	0	6	8
44	R:R:M22	R:R:R310	11.17	No	No	0	3	9
45	R:R:F27	R:R:L31	4.87	No	No	0	8	6
46	R:R:F27	R:R:S80	11.89	No	No	0	8	8
47	R:R:I317	R:R:T29	6.08	No	No	0	9	6
48	R:R:G30	R:R:K76	3.49	No	Yes	1	9	8
49	R:R:G30	R:R:I317	5.29	No	No	1	9	9
50	R:R:L31	R:R:L35	5.54	No	No	0	6	5
51	R:R:G33	R:R:W321	4.22	No	Yes	0	9	8
52	R:R:D72	R:R:N34	6.73	Yes	No	0	9	9
53	R:R:N34	R:R:P320	11.4	No	No	0	9	9
54	R:R:L35	R:R:L73	4.15	No	No	0	5	8
55	R:R:I325	R:R:L36	4.28	No	No	0	8	5
56	R:R:A37	R:R:I324	6.5	No	Yes	0	9	9
57	R:R:A37	R:R:I325	3.25	No	No	0	9	8
58	R:R:L38	R:R:T69	4.42	No	No	0	7	8
59	R:R:L40	R:R:S328	3	No	No	0	8	7
60	R:R:L41	R:R:Y62	7.03	Yes	Yes	4	9	7
61	R:R:L41	R:R:V65	2.98	Yes	No	4	9	8
62	R:R:C66	R:R:L41	6.35	No	Yes	4	6	9
63	R:R:I324	R:R:L41	5.71	Yes	Yes	4	9	9
64	R:R:G47	R:R:L46	3.42	No	No	0	5	4
65	R:R:P58	R:R:Y62	5.56	No	Yes	0	6	7
66	R:R:L146	R:R:P58	3.28	No	No	0	4	6
67	R:R:E129	R:R:V60	4.28	No	Yes	5	9	7
68	R:R:V60	R:R:Y140	5.05	Yes	Yes	5	7	8
69	R:R:I144	R:R:V60	3.07	No	Yes	5	5	7
70	R:R:F61	R:R:V65	7.87	No	No	0	9	8
71	R:R:F61	R:R:R327	4.28	No	No	0	9	9
72	R:R:C66	R:R:Y62	9.41	No	Yes	4	6	7
73	R:R:L64	R:R:M126	5.65	No	No	0	8	9
74	R:R:E129	R:R:L64	3.98	No	No	0	9	8
75	R:R:L64	R:R:V152	4.47	No	No	0	8	5
76	R:R:I324	R:R:V65	3.07	Yes	No	4	9	8
77	R:R:D72	R:R:L68	6.79	Yes	Yes	2	9	9
78	R:R:L68	R:R:Q122	6.65	Yes	No	0	9	7
79	R:R:L123	R:R:L68	4.15	No	Yes	2	8	9
80	R:R:L68	R:R:M126	5.65	Yes	No	0	9	9
81	R:R:D319	R:R:L68	5.43	Yes	Yes	2	9	9
82	R:R:I324	R:R:T69	4.56	Yes	No	0	9	8
83	R:R:Q122	R:R:T71	9.92	No	No	0	7	9
84	R:R:D72	R:R:S316	8.83	Yes	No	0	9	8
85	R:R:D319	R:R:D72	7.98	Yes	Yes	2	9	9
86	R:R:C77	R:R:L73	3.17	No	No	0	6	8
87	R:R:F115	R:R:G75	9.03	Yes	No	0	8	9
88	R:R:K76	R:R:S316	4.59	Yes	No	0	8	8
89	R:R:I317	R:R:K76	5.82	No	Yes	1	9	8
90	R:R:F111	R:R:L78	4.87	No	No	0	5	6
91	R:R:F108	R:R:L79	7.31	Yes	No	0	6	6
92	R:R:F108	R:R:V82	5.24	Yes	No	0	6	6
93	R:R:A86	R:R:T181	3.36	No	Yes	0	6	9
94	R:R:T181	R:R:Y87	14.98	Yes	No	1	9	8
95	R:R:Q89	R:R:R91	10.51	No	No	0	5	3
96	R:R:Q176	R:R:S92	7.22	Yes	No	0	5	5
97	R:R:F108	R:R:L93	6.09	Yes	No	0	6	6
98	R:R:C183	R:R:L93	3.17	No	No	0	9	6
99	R:R:N102	R:R:R94	9.64	No	No	0	1	2
100	R:R:Q176	R:R:R94	5.84	Yes	No	0	5	2
101	R:R:L104	R:R:L96	4.15	No	Yes	6	5	4
102	R:R:A97	R:R:L100	4.73	No	No	0	1	4
103	R:R:L100	R:R:L104	4.15	No	No	0	4	5
104	R:R:N102	R:R:Q106	9.24	No	No	0	1	4
105	R:R:C105	R:R:C183	7.28	No	No	0	9	9
106	R:R:F174	R:R:Q106	4.68	Yes	No	0	6	4
107	R:R:F108	R:R:M112	3.73	Yes	Yes	0	6	8
108	R:R:F108	R:R:W182	3.01	Yes	Yes	0	6	9
109	R:R:A109	R:R:F174	6.93	No	Yes	0	8	6
110	R:R:F110	R:R:F111	8.57	No	No	0	7	5
111	R:R:F110	R:R:F168	8.57	No	No	0	7	4
112	R:R:F111	R:R:F115	3.22	No	Yes	0	5	8
113	R:R:F184	R:R:M112	6.22	Yes	Yes	1	8	8
114	R:R:L309	R:R:M112	4.24	Yes	Yes	1	7	8
115	R:R:C164	R:R:S113	5.16	No	No	0	8	7
116	R:R:I185	R:R:S113	3.1	Yes	No	1	7	7
117	R:R:S113	R:R:Y203	3.82	No	Yes	1	7	8
118	R:R:F114	R:R:F115	10.72	No	Yes	0	7	8
119	R:R:F114	R:R:S118	6.61	No	No	0	7	7
120	R:R:F114	R:R:L161	6.09	No	No	0	7	3
121	R:R:L117	R:R:S160	6.01	Yes	No	0	8	7
122	R:R:F163	R:R:L117	4.87	Yes	Yes	1	7	8
123	R:R:C164	R:R:L117	3.17	No	Yes	0	8	8
124	R:R:L117	R:R:Y203	4.69	Yes	Yes	1	8	8
125	R:R:S118	R:R:S160	4.89	No	No	0	7	7
126	R:R:M207	R:R:T120	6.02	No	No	0	7	7
127	R:R:L210	R:R:T120	4.42	No	No	0	6	7
128	R:R:L121	R:R:V156	4.47	No	No	0	5	6
129	R:R:L121	R:R:L210	4.15	No	No	0	5	6
130	R:R:Q122	R:R:V156	4.3	No	No	0	7	6
131	R:R:D319	R:R:L123	4.07	Yes	No	2	9	8
132	R:R:A213	R:R:L124	3.15	No	No	0	6	5
133	R:R:L124	R:R:T214	5.9	No	No	0	5	8
134	R:R:F323	R:R:M126	7.46	Yes	No	0	9	9
135	R:R:A127	R:R:N218	3.13	No	No	0	9	9
136	R:R:C217	R:R:L128	3.17	No	No	0	7	7
137	R:R:E129	R:R:Y140	11.22	No	Yes	5	9	8
138	R:R:A221	R:R:C130	3.61	No	No	0	9	9
139	R:R:L132	R:R:W131	4.56	No	Yes	7	5	6
140	R:R:H136	R:R:W131	6.35	Yes	Yes	7	4	6
141	R:R:H136	R:R:L132	3.86	Yes	No	7	4	5
142	R:R:S133	R:R:Y140	7.63	No	Yes	0	9	8
143	R:R:L134	R:R:L225	4.15	No	No	0	8	9
144	R:R:G135	R:R:N224	5.09	No	No	0	7	7
145	R:R:F139	R:R:H143	11.31	No	No	0	5	5
146	R:R:I144	R:R:Y140	16.92	No	Yes	5	5	8
147	R:R:H143	R:R:R142	9.03	No	No	0	5	5
148	R:R:L148	R:R:R147	4.86	No	No	0	5	4
149	R:R:F159	R:R:F163	4.29	No	Yes	0	4	7
150	R:R:F163	R:R:Y199	4.13	Yes	Yes	1	7	6
151	R:R:F163	R:R:L202	4.87	Yes	No	0	7	5
152	R:R:F163	R:R:Y203	3.09	Yes	Yes	1	7	8
153	R:R:F163	R:R:L206	4.87	Yes	No	0	7	5
154	R:R:L166	R:R:Y199	4.69	No	Yes	0	7	6
155	R:R:F174	R:R:P167	8.67	Yes	No	0	6	9
156	R:R:P167	R:R:Y199	12.52	No	Yes	0	9	6
157	R:R:F168	R:R:F174	4.29	No	Yes	0	4	6
158	R:R:F171	R:R:G198	3.01	No	No	0	4	4
159	R:R:F171	R:R:Y199	8.25	No	Yes	0	4	6
160	R:R:G172	R:R:Y199	4.35	No	Yes	0	8	6
161	R:R:K173	R:R:Q186	5.42	No	Yes	1	2	5
162	R:R:K173	R:R:V196	6.07	No	Yes	1	2	5
163	R:R:F174	R:R:I185	5.02	Yes	Yes	0	6	7
164	R:R:V175	R:R:Y177	3.79	Yes	Yes	1	4	9
165	R:R:Q186	R:R:V175	5.73	Yes	Yes	1	5	4
166	R:R:G180	R:R:Q176	6.58	No	Yes	0	6	5
167	R:R:C183	R:R:Q176	4.58	No	Yes	0	9	5
168	R:R:W182	R:R:Y177	17.36	Yes	Yes	1	9	9
169	R:R:F184	R:R:Y177	5.16	Yes	Yes	1	8	9
170	R:R:M187	R:R:Y177	7.18	Yes	Yes	1	7	9
171	R:R:D305	R:R:Y177	8.05	No	Yes	1	7	9
172	R:R:C178	R:R:E302	9.12	No	No	3	4	3
173	R:R:P179	R:R:T181	5.25	No	Yes	0	8	9
174	R:R:F184	R:R:W182	3.01	Yes	Yes	1	8	9
175	R:R:L306	R:R:W182	5.69	No	Yes	1	7	9
176	R:R:L309	R:R:W182	7.97	Yes	Yes	1	7	9
177	R:R:F184	R:R:I185	7.54	Yes	Yes	1	8	7
178	R:R:F184	R:R:L309	6.09	Yes	Yes	1	8	7
179	R:R:I185	R:R:Y199	7.25	Yes	Yes	1	7	6
180	R:R:I185	R:R:Y203	8.46	Yes	Yes	1	7	8
181	R:R:Q186	R:R:V196	5.73	Yes	Yes	1	5	5
182	R:R:M187	R:R:S200	3.07	Yes	No	0	7	7
183	R:R:A285	R:R:M187	3.22	No	Yes	0	7	7
184	R:R:D305	R:R:M187	4.16	No	Yes	1	7	7
185	R:R:V188	R:R:V293	3.21	Yes	Yes	1	3	1
186	R:R:K296	R:R:V188	3.04	No	Yes	0	1	3
187	R:R:E191	R:R:H189	3.69	No	Yes	0	1	4
188	R:R:G192	R:R:H189	3.18	No	Yes	0	1	4
189	R:R:H189	R:R:S193	6.97	Yes	No	1	4	3
190	R:R:H189	R:R:V196	9.69	Yes	Yes	1	4	5
191	R:R:H189	R:R:L197	3.86	Yes	No	0	4	4
192	R:R:E190	R:R:V293	8.56	No	Yes	0	1	1
193	R:R:S193	R:R:V196	6.46	No	Yes	1	3	5
194	R:R:Y199	R:R:Y203	4.96	Yes	Yes	1	6	8
195	R:R:M207	R:R:Y203	3.59	No	Yes	0	7	8
196	R:R:A285	R:R:S204	3.42	No	No	0	7	8
197	R:R:S205	R:R:Y286	5.09	No	No	0	4	5
198	R:R:A208	R:R:I282	3.25	No	No	0	6	8
199	R:R:F274	R:R:V211	6.55	Yes	No	8	9	8
200	R:R:S278	R:R:V211	3.23	No	No	8	9	8
201	R:R:L212	R:R:L216	4.15	No	No	0	3	4
202	R:R:F274	R:R:T214	10.38	Yes	No	0	9	8
203	R:R:L219	R:R:V215	2.98	No	No	0	5	6
204	R:R:T271	R:R:V215	3.17	No	No	0	8	6
205	R:R:L267	R:R:N218	4.12	No	No	0	9	9
206	R:R:N218	R:R:T271	5.85	No	No	0	9	8
207	R:R:L264	R:R:M222	7.07	No	No	0	7	7
208	R:R:L267	R:R:M222	5.65	No	No	0	9	7
209	R:R:N224	R:R:R223	4.82	No	No	0	7	4
210	R:R:L225	R:R:L264	4.15	No	No	0	9	7
211	R:R:R230	R:R:Y226	7.2	No	No	0	5	5
212	R:R:M228	R:R:R231	3.72	No	No	0	8	5
213	R:R:E260	R:R:M228	6.77	No	No	0	9	8
214	R:R:H229	R:R:Q233	16.07	No	No	0	6	3
215	R:R:H229	R:R:L261	20.57	No	No	0	6	5
216	R:R:Q233	R:R:R230	4.67	No	No	0	3	5
217	R:R:P255	R:R:P329	3.9	No	No	0	2	7
218	R:R:H336	R:R:Q256	3.71	No	No	0	4	5
219	R:R:D262	R:R:L258	8.14	No	Yes	0	9	6
220	R:R:H263	R:R:L258	7.71	No	Yes	0	8	6
221	R:R:L258	R:R:R332	9.72	Yes	No	0	6	6
222	R:R:L266	R:R:R327	7.29	No	No	0	8	9
223	R:R:D319	R:R:M270	4.16	Yes	No	2	9	9
224	R:R:I322	R:R:M270	5.83	No	No	2	8	9
225	R:R:F323	R:R:M270	3.73	Yes	No	2	9	9
226	R:R:F274	R:R:S278	5.28	Yes	No	8	9	9
227	R:R:C277	R:R:V314	3.42	No	No	0	9	4
228	R:R:C277	R:R:I315	3.27	No	No	0	9	9
229	R:R:L309	R:R:V281	2.98	Yes	No	0	7	8
230	R:R:L312	R:R:V281	2.98	No	No	0	8	8
231	R:R:Y283	R:R:Y287	11.91	No	Yes	0	6	4
232	R:R:E301	R:R:R284	10.47	No	No	0	3	5
233	R:R:E304	R:R:R284	5.82	No	No	0	1	5
234	R:R:D305	R:R:R284	13.1	No	No	0	7	5
235	R:R:F290	R:R:Y286	7.22	No	No	0	3	5
236	R:R:K291	R:R:Y287	9.55	No	Yes	0	3	4
237	R:R:K296	R:R:Y287	9.55	No	Yes	0	1	4
238	R:R:E301	R:R:Y287	6.73	No	Yes	0	3	4
239	R:R:A289	R:R:F290	4.16	No	No	0	7	3
240	R:R:E295	R:R:K291	8.1	No	No	0	1	3
241	R:R:D292	R:R:K294	5.53	No	No	0	2	1
242	R:R:K294	R:R:V293	4.55	No	Yes	0	1	1
243	R:R:N297	R:R:T299	5.85	No	No	0	3	1
244	R:R:N297	R:R:S300	8.94	No	No	0	3	1
245	R:R:E302	R:R:R298	4.65	No	No	3	3	1
246	R:R:E304	R:R:R307	10.47	No	No	0	1	4
247	R:R:L306	R:R:R310	12.15	No	No	1	7	9
248	R:R:F311	R:R:R307	3.21	No	No	0	6	4
249	R:R:D319	R:R:I315	4.2	Yes	No	0	9	9
250	R:R:D319	R:R:F323	3.58	Yes	Yes	2	9	9
251	R:R:I325	R:R:W321	15.27	No	Yes	0	8	8
252	R:R:F326	R:R:W321	9.02	No	Yes	0	5	8
253	R:R:F323	R:R:I322	5.02	Yes	No	2	9	8
254	R:R:F326	R:R:F331	8.57	No	No	0	5	7
255	R:R:F331	R:R:F335	5.36	No	No	0	7	4
256	R:R:K337	R:R:R332	6.19	No	No	0	3	6
257	R:R:L148	R:R:T145	2.95	No	No	0	5	6
258	R:R:L279	R:R:T275	2.95	No	No	0	7	5
259	R:R:G45	R:R:Y62	2.9	No	Yes	0	6	7
260	R:R:F311	R:R:P280	2.89	No	No	0	6	9
261	R:R:P329	R:R:R332	2.88	No	No	0	7	6
262	R:R:I322	R:R:L269	2.85	No	No	0	8	5
263	R:R:L134	R:R:M228	2.83	No	No	0	8	8
264	R:R:G220	R:R:W131	2.81	No	Yes	0	5	6
265	R:R:L124	R:R:L128	2.77	No	No	0	5	7
266	R:R:P320	R:R:W321	2.7	No	Yes	0	9	8
267	R:R:L96	R:R:Q89	2.66	Yes	No	0	4	5
268	R:R:E260	R:R:L232	2.65	No	No	0	9	5
269	R:R:C217	R:R:W131	2.61	No	Yes	0	7	6
270	R:R:D262	R:R:E259	2.6	No	No	0	9	6
271	R:R:F274	R:R:T120	2.59	Yes	No	0	9	7
272	R:R:H263	R:R:L225	2.57	No	No	0	8	9
273	R:R:H235	R:R:L232	2.57	No	No	0	4	5
274	R:R:F334	R:R:I333	2.51	No	No	0	4	5
275	R:R:E260	R:R:H229	2.46	No	No	0	9	6
276	R:R:F27	R:R:L84	2.44	No	No	0	8	7
277	R:R:F115	R:R:L74	2.44	Yes	No	0	8	4
278	R:R:F139	R:R:L132	2.44	No	No	0	5	5
279	R:R:L151	R:R:R147	2.43	No	No	0	3	4
280	R:R:L258	R:R:R327	2.43	Yes	No	0	6	9
281	R:R:I282	R:R:Y286	2.42	No	No	0	8	5
282	L:L:?1	R:R:G23	2.25	Yes	No	0	0	8
283	L:L:?1	R:R:G116	2.25	Yes	No	0	0	8
284	R:R:G23	R:R:G24	2.11	No	No	0	8	4
285	R:R:C66	R:R:G67	1.96	No	No	0	6	6
286	R:R:A153	R:R:G67	1.95	No	No	0	7	6
287	R:R:A97	R:R:P98	1.87	No	No	0	1	5
288	R:R:A153	R:R:P154	1.87	No	No	0	7	4
289	R:R:A308	R:R:P280	1.87	No	No	0	7	9
290	R:R:G45	R:R:S44	1.86	No	No	0	6	7
291	R:R:G149	R:R:V60	1.84	No	Yes	0	7	7
292	R:R:G149	R:R:V152	1.84	No	No	0	7	5
293	R:R:G288	R:R:V188	1.84	No	Yes	0	7	3
294	R:R:P81	R:R:S80	1.78	No	No	0	8	8
295	R:R:P329	R:R:S328	1.78	No	No	0	7	7
296	R:R:G149	R:R:L148	1.71	No	No	0	7	5
297	R:R:G17	R:R:N18	1.7	No	No	0	3	3
298	R:R:A125	R:R:V152	1.7	No	No	0	7	5
299	R:R:A289	R:R:V201	1.7	No	No	0	7	4
300	R:R:I333	R:R:P255	1.69	No	No	0	5	2
301	R:R:M63	R:R:P58	1.68	No	No	0	6	6
302	R:R:L279	R:R:P280	1.64	No	No	0	7	9
303	R:R:S118	R:R:S157	1.63	No	No	0	7	6
304	R:R:S193	R:R:S195	1.63	No	No	0	3	1
305	R:R:S92	R:R:V95	1.62	No	No	0	5	2
306	R:R:S328	R:R:V330	1.62	No	No	0	7	7
307	R:R:A150	R:R:M63	1.61	No	No	0	5	6
308	R:R:A165	R:R:M169	1.61	No	No	0	5	3
309	R:R:A268	R:R:M222	1.61	No	No	0	6	7
310	R:R:S119	R:R:T71	1.6	No	No	0	8	9
311	R:R:V314	R:R:V318	1.6	No	No	0	4	8
312	R:R:T181	R:R:V14	1.59	Yes	No	0	9	4
313	R:R:C130	R:R:L134	1.59	No	No	0	9	8
314	R:R:C130	R:R:L267	1.59	No	No	0	9	9
315	R:R:G135	R:R:H136	1.59	No	Yes	0	7	4
316	R:R:A85	R:R:L96	1.58	No	Yes	0	6	4
317	R:R:A289	R:R:L197	1.58	No	No	0	7	4
318	R:R:P257	R:R:Q256	1.58	No	No	0	6	5
319	R:R:H136	R:R:P137	1.53	Yes	No	0	4	9
320	R:R:L74	R:R:V70	1.49	No	No	0	4	5
321	R:R:L96	R:R:V82	1.49	Yes	No	6	4	6
322	R:R:L104	R:R:V82	1.49	No	No	6	5	6
323	R:R:L151	R:R:V155	1.49	No	No	0	3	3
324	R:R:L273	R:R:V318	1.49	No	No	0	8	8
325	R:R:L166	R:R:M169	1.41	No	No	0	7	3
326	R:R:L273	R:R:M276	1.41	No	No	0	8	5
327	R:R:A227	R:R:R231	1.38	No	No	0	4	5
328	R:R:L265	R:R:L269	1.38	No	No	0	6	5
329	R:R:K337	R:R:Q256	1.36	No	No	0	3	5
330	R:R:D101	R:R:N102	1.35	No	No	0	4	1
331	R:R:F61	R:R:S59	1.32	No	No	0	9	7
332	R:R:F138	R:R:R142	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.83143	14	1	0
2	R:R:F5	8.2625	4	1	4
3	R:R:Y6	8.89	5	1	6
4	R:R:R7	8.18	5	3	4
5	R:R:E15	5.6	4	3	3
6	R:R:L41	5.5175	4	4	9
7	R:R:V60	3.56	4	5	7
8	R:R:Y62	6.225	4	4	7
9	R:R:L68	5.734	5	2	9
10	R:R:D72	7.5825	4	2	9
11	R:R:K76	6.49	4	1	8
12	R:R:L96	2.47	4	6	4
13	R:R:F108	5.076	5	0	6
14	R:R:M112	5.4075	4	1	8
15	R:R:F115	6.3525	4	0	8
16	R:R:L117	4.685	4	1	8
17	R:R:W131	4.0825	4	7	6
18	R:R:H136	3.3325	4	7	4
19	R:R:Y140	10.205	4	5	8
20	R:R:F163	4.35333	6	1	7
21	R:R:F174	5.918	5	0	6
22	R:R:V175	6.6525	4	1	4
23	R:R:Q176	6.055	4	0	5
24	R:R:Y177	8.57833	6	1	9
25	R:R:T181	6.006	5	1	9
26	R:R:W182	7.67167	6	1	9
27	R:R:F184	5.604	5	1	8
28	R:R:I185	6.274	5	1	7
29	R:R:Q186	5.91	4	1	5
30	R:R:M187	4.4075	4	1	7
31	R:R:V188	5.25	5	1	3
32	R:R:H189	5.478	5	1	4
33	R:R:V196	6.9875	4	1	5
34	R:R:Y199	6.59286	7	1	6
35	R:R:Y203	4.76833	6	1	8
36	R:R:L258	7	4	0	6
37	R:R:F274	6.2	4	8	9
38	R:R:Y287	9.435	4	0	4
39	R:R:V293	5.0625	4	1	1
40	R:R:L309	5.32	4	1	7
41	R:R:D319	4.90333	6	2	9
42	R:R:W321	7.8025	4	0	8
43	R:R:F323	4.9475	4	2	9
44	R:R:I324	4.96	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V175	R:R:Y177	19.6671	3.79	Yes	Yes	1	4	9
2	R:R:W182	R:R:Y177	49.1535	17.36	Yes	Yes	1	9	9
3	L:L:?1	R:R:W182	78.2372	8.99	Yes	Yes	1	0	9
4	L:L:?1	R:R:K76	100	12.06	Yes	Yes	1	0	8
5	L:L:?1	R:R:S80	11.4018	10.86	Yes	No	0	0	8
6	R:R:F184	R:R:Y177	18.4874	5.16	Yes	Yes	1	8	9
7	R:R:F184	R:R:M112	28.0215	6.22	Yes	Yes	1	8	8
8	L:L:?1	R:R:T181	23.5093	4.85	Yes	Yes	1	0	9
9	R:R:F5	R:R:Y6	10.3218	11.35	Yes	Yes	1	4	6
10	R:R:V188	R:R:Y6	10.8493	5.05	Yes	Yes	1	3	6
11	R:R:Q186	R:R:V175	15.5327	5.73	Yes	Yes	1	5	4
12	R:R:P179	R:R:T181	17.2827	5.25	No	Yes	0	8	9
13	R:R:E15	R:R:P179	13.4975	3.14	Yes	No	0	3	8
14	R:R:K76	R:R:S316	97.6191	4.59	Yes	No	0	8	8
15	R:R:D72	R:R:S316	97.2306	8.83	Yes	No	0	9	8
16	R:R:D72	R:R:N34	83.2769	6.73	Yes	No	0	9	9
17	R:R:N34	R:R:P320	82.4429	11.4	No	No	0	9	9
18	R:R:P320	R:R:W321	81.6017	2.7	No	Yes	0	9	8
19	R:R:I325	R:R:W321	77.3497	15.27	No	Yes	0	8	8
20	R:R:A37	R:R:I325	75.5747	3.25	No	No	0	9	8
21	R:R:A37	R:R:I324	74.6766	6.5	No	Yes	0	9	9
22	R:R:I324	R:R:V65	58.2243	3.07	Yes	No	4	9	8
23	R:R:F61	R:R:V65	59.3791	7.87	No	No	0	9	8
24	R:R:F61	R:R:R327	57.3155	4.28	No	No	0	9	9
25	R:R:L258	R:R:R327	55.3124	2.43	Yes	No	0	6	9
26	R:R:L258	R:R:R332	15.8356	9.72	Yes	No	0	6	6
27	R:R:I324	R:R:L41	13.6971	5.71	Yes	Yes	4	9	9
28	R:R:D72	R:R:L68	28.8342	6.79	Yes	Yes	2	9	9
29	R:R:L68	R:R:M126	20.6259	5.65	Yes	No	0	9	9
30	R:R:L64	R:R:M126	19.5459	5.65	No	No	0	8	9
31	R:R:L64	R:R:V152	10.5678	4.47	No	No	0	8	5
32	R:R:L68	R:R:Q122	16.3809	6.65	Yes	No	0	9	7
33	R:R:D319	R:R:D72	18.1381	7.98	Yes	Yes	2	9	9
34	R:R:F168	R:R:F174	13.7078	4.29	No	Yes	0	4	6
35	R:R:F110	R:R:F168	11.9685	8.57	No	No	0	7	4
36	R:R:F110	R:R:F111	10.2292	8.57	No	No	0	7	5
37	R:R:F108	R:R:W182	16.5984	3.01	Yes	Yes	0	6	9
38	R:R:F108	R:R:V82	17.3183	5.24	Yes	No	0	6	6
39	R:R:F184	R:R:I185	73.4291	7.54	Yes	Yes	1	8	7
40	R:R:I185	R:R:Y203	34.045	8.46	Yes	Yes	1	7	8
41	R:R:L117	R:R:Y203	10.967	4.69	Yes	Yes	1	8	8
42	R:R:I185	R:R:Y199	18.2949	7.25	Yes	Yes	1	7	6
43	R:R:M207	R:R:Y203	23.52	3.59	No	Yes	0	7	8
44	R:R:M207	R:R:T120	23.1564	6.02	No	No	0	7	7
45	R:R:L210	R:R:T120	14.0999	4.42	No	No	0	6	7
46	R:R:L121	R:R:L210	13.633	4.15	No	No	0	5	6
47	R:R:Q122	R:R:V156	14.05	4.3	No	No	0	7	6
48	R:R:L121	R:R:V156	13.5724	4.47	No	No	0	5	6
49	R:R:F274	R:R:T120	25.9436	2.59	Yes	No	0	9	7
50	R:R:F274	R:R:T214	22.2333	10.38	Yes	No	0	9	8
51	R:R:L124	R:R:T214	20.9823	5.9	No	No	0	5	8
52	R:R:H263	R:R:L258	39.0241	7.71	No	Yes	0	8	6
53	R:R:H263	R:R:L225	37.8693	2.57	No	No	0	8	9
54	R:R:L134	R:R:L225	25.4161	4.15	No	No	0	8	9
55	R:R:C130	R:R:L134	10.5713	1.59	No	No	0	9	8
56	R:R:L267	R:R:N218	13.0057	4.12	No	No	0	9	9
57	R:R:L225	R:R:L264	11.5515	4.15	No	No	0	9	7
58	R:R:L264	R:R:M222	10.2684	7.07	No	No	0	7	7
59	R:R:L124	R:R:L128	18.4589	2.77	No	No	0	5	7
60	R:R:C217	R:R:L128	17.1864	3.17	No	No	0	7	7
61	R:R:C217	R:R:W131	15.9069	2.61	No	Yes	0	7	6
62	R:R:Q186	R:R:V196	28.0393	5.73	Yes	Yes	1	5	5
63	R:R:D305	R:R:Y177	13.8753	8.05	No	Yes	1	7	9
64	R:R:H189	R:R:V196	22.1086	9.69	Yes	Yes	1	4	5
65	R:R:H189	R:R:L197	16.2206	3.86	Yes	No	0	4	4
66	R:R:A289	R:R:L197	14.2175	1.58	No	No	0	7	4
67	R:R:A289	R:R:F290	10.19	4.16	No	No	0	7	3
68	R:R:L134	R:R:M228	14.4884	2.83	No	No	0	8	8
69	R:R:E260	R:R:M228	10.6177	6.77	No	No	0	9	8
70	R:R:D305	R:R:R284	13.1126	13.1	No	No	0	7	5
71	R:R:F174	R:R:I185	22.825	5.02	Yes	Yes	0	6	7
72	R:R:Y177	R:R:Y6	33.881	9.93	Yes	Yes	1	9	6
73	L:L:?1	R:R:M112	34.6937	7.44	Yes	Yes	1	0	8
74	R:R:F108	R:R:M112	12.3499	3.73	Yes	Yes	0	6	8
75	R:R:F184	R:R:W182	28.435	3.01	Yes	Yes	1	8	9
76	R:R:Q186	R:R:Y6	16.2705	6.76	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L26	3.64	1	Yes	No	0	8	0	1
L:L:?1	R:R:K76	12.06	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S80	10.86	1	Yes	No	0	8	0	1
L:L:?1	R:R:V83	7.84	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y87	6.94	1	Yes	No	0	8	0	1
L:L:?1	R:R:M112	7.44	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T181	4.85	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:W182	8.99	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:L306	4.55	1	Yes	No	0	7	0	1
L:L:?1	R:R:R310	5.59	1	Yes	No	0	9	0	1
L:L:?1	R:R:L312	4.55	1	Yes	No	0	8	0	1
L:L:?1	R:R:S313	13.83	1	Yes	No	0	9	0	1
R:R:A20	R:R:Y87	6.67	0	No	No	6	8	2	1
R:R:M22	R:R:R310	11.17	0	No	No	3	9	2	1
R:R:F27	R:R:S80	11.89	0	No	No	8	8	2	1
R:R:G30	R:R:K76	3.49	1	No	Yes	9	8	2	1
R:R:G30	R:R:I317	5.29	1	No	No	9	9	2	2
R:R:K76	R:R:S316	4.59	1	Yes	No	8	8	1	2
R:R:I317	R:R:K76	5.82	1	No	Yes	9	8	2	1
R:R:A86	R:R:T181	3.36	0	No	Yes	6	9	2	1
R:R:T181	R:R:Y87	14.98	1	Yes	No	9	8	1	1
R:R:F108	R:R:M112	3.73	0	Yes	Yes	6	8	2	1
R:R:F108	R:R:W182	3.01	0	Yes	Yes	6	9	2	1
R:R:F184	R:R:M112	6.22	1	Yes	Yes	8	8	2	1
R:R:L309	R:R:M112	4.24	1	Yes	Yes	7	8	2	1
R:R:W182	R:R:Y177	17.36	1	Yes	Yes	9	9	1	2
R:R:F184	R:R:Y177	5.16	1	Yes	Yes	8	9	2	2
R:R:P179	R:R:T181	5.25	0	No	Yes	8	9	2	1
R:R:F184	R:R:W182	3.01	1	Yes	Yes	8	9	2	1
R:R:L306	R:R:W182	5.69	1	No	Yes	7	9	1	1
R:R:L309	R:R:W182	7.97	1	Yes	Yes	7	9	2	1
R:R:F184	R:R:L309	6.09	1	Yes	Yes	8	7	2	2
R:R:L309	R:R:V281	2.98	1	Yes	No	7	8	2	2
R:R:L312	R:R:V281	2.98	0	No	No	8	8	1	2
R:R:L306	R:R:R310	12.15	1	No	No	7	9	1	1
L:L:?1	R:R:G23	2.25	1	Yes	No	0	8	0	1
L:L:?1	R:R:G116	2.25	1	Yes	No	0	8	0	1
R:R:G23	R:R:G24	2.11	0	No	No	8	4	1	2
R:R:P81	R:R:S80	1.78	0	No	No	8	8	2	1
R:R:T181	R:R:V14	1.59	1	Yes	No	9	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9E9S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	288
Number of Links	332
Number of Hubs	44
Number of Links mediated by Hubs	165
Number of Communities	8
Number of Nodes involved in Communities	65
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	62656
Length Of Smallest Path	3
Average Path Length	14.6915
Length of Longest Path	37
Minimum Path Strength	1.45
Average Path Strength	6.3779
Maximum Path Strength	18.32
Minimum Path Correlation	0.7
Average Path Correlation	0.91972
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.1993
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0433
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • prostanoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin D receptor activity • prostaglandin receptor activity • prostaglandin J receptor activity • multicellular organismal process • sleep • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • developmental process • multicellular organism development • sex determination • male sex determination • reproductive process • anatomical structure development • developmental process involved in reproduction • defense response • response to stress • inflammatory response • cellular response to prostaglandin D stimulus • response to prostaglandin D • carbohydrate derivative metabolic process • primary metabolic process • nucleoside metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • adenosine metabolic process • nucleobase-containing small molecule metabolic process • metabolic process • small molecule metabolic process • purine nucleoside metabolic process • ribonucleoside metabolic process • purine ribonucleoside metabolic process • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	PG2
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PG2
Name	Prostaglandin D2
Synonyms	(5E,13E)-9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	448457
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13258
Sequence	>9E9S_nogp_Chain_R S P F Y R C Q N T T S V E K G N S A V M G G V L F S T G L L G N L L A L G L L A R S G L G P S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N R S L R V L A P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H P F F Y R R H I T L R L G A L V A P V V S A F S L A F C A L P F M G F G K F V Q Y C P G T W C F I Q M V H E E G S L S V L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K D V K E K N R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P V F R I F F H K I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9E9S	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ1	2.68	2025-09-03	To be published
	9E9S (No Gprot)	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-		2.68	2025-09-03	To be published
	9EE5	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-2550289	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9EI5	A	Lipid	Prostanoid	DP₁	Homo sapiens	-	-	-	2.84	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9EKH	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-3030297	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9UWD	A	Lipid	Prostaglandin	DP₁	Homo sapiens	-	-	-	-	2025-04-09	doi.org/10.1073/pnas.2501902122
	8ZVZ	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZVZ (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	9AU0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.45	2025-08-27	To be published
	9AU0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.45	2025-08-27	To be published

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